Masahiko Watanabe

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. ncbi request reprint [Glutamate signaling and neural plasticity]
    Masahiko Watanabe
    Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido
    No To Hattatsu 45:267-74. 2013
  2. doi request reprint Climbing fiber synapse elimination in cerebellar Purkinje cells
    Masahiko Watanabe
    Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Eur J Neurosci 34:1697-710. 2011
  3. pmc Dynorphin is expressed primarily by GABAergic neurons that contain galanin in the rat dorsal horn
    Thomas C P Sardella
    Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ UK
    Mol Pain 7:76. 2011
  4. pmc Galanin-immunoreactivity identifies a distinct population of inhibitory interneurons in laminae I-III of the rat spinal cord
    Sheena Y X Tiong
    College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ UK
    Mol Pain 7:36. 2011
  5. pmc Expression of AMPA receptor subunits at synapses in laminae I-III of the rodent spinal dorsal horn
    Erika Polgár
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Mol Pain 4:5. 2008
  6. pmc Phosphorylation of ERK in neurokinin 1 receptor-expressing neurons in laminae III and IV of the rat spinal dorsal horn following noxious stimulation
    Erika Polgár
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Mol Pain 3:4. 2007
  7. pmc Diacylglycerol kinase beta promotes dendritic outgrowth and spine maturation in developing hippocampal neurons
    Yasukazu Hozumi
    Department of Anatomy and Cell Biology, Yamagata University School of Medicine, Yamagata 990 9585, Japan
    BMC Neurosci 10:99. 2009
  8. ncbi request reprint Patterns of expression for the mRNA corresponding to the four isoforms of phospholipase Cbeta in mouse brain
    M Watanabe
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo, Japan
    Eur J Neurosci 10:2016-25. 1998
  9. ncbi request reprint Glial processes are glued to synapses via Ca(2+)-permeable glutamate receptors
    Masahiko Watanabe
    Dept of Anatomy, Hokkaido University School of Medicine, 060 8638, Sapporo, Japan
    Trends Neurosci 25:5-6. 2002
  10. doi request reprint Effects of FAK ablation on cerebellar foliation, Bergmann glia positioning and climbing fiber territory on Purkinje cells
    Fumihiro Watanabe
    Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Eur J Neurosci 27:836-54. 2008

Detail Information

Publications123 found, 100 shown here

  1. ncbi request reprint [Glutamate signaling and neural plasticity]
    Masahiko Watanabe
    Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido
    No To Hattatsu 45:267-74. 2013
    ..Thus, armed with both molecular mechanisms, functional neural circuits develop and mature during the early postnatal period...
  2. doi request reprint Climbing fiber synapse elimination in cerebellar Purkinje cells
    Masahiko Watanabe
    Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Eur J Neurosci 34:1697-710. 2011
    ..In contrast, the late phase is mediated by the mGluR1-Gαq-PLCβ4-PKCγ signaling cascade in PCs driven at PF-PC synapses, whose structural connectivity is stabilized and maintained by the GluRδ2-Cbln1-neurexin system...
  3. pmc Dynorphin is expressed primarily by GABAergic neurons that contain galanin in the rat dorsal horn
    Thomas C P Sardella
    Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ UK
    Mol Pain 7:76. 2011
    ..The main aims were to estimate the proportion of neurons in each of laminae I-III that express dynorphin and to determine whether they are excitatory or inhibitory neurons...
  4. pmc Galanin-immunoreactivity identifies a distinct population of inhibitory interneurons in laminae I-III of the rat spinal cord
    Sheena Y X Tiong
    College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ UK
    Mol Pain 7:36. 2011
    ..We also estimated the proportion of neurons and GABAergic axons that contain galanin in laminae I-III...
  5. pmc Expression of AMPA receptor subunits at synapses in laminae I-III of the rodent spinal dorsal horn
    Erika Polgár
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Mol Pain 4:5. 2008
    ..In addition, we have compared staining of AMPArs with that for PSD-95, a major constituent of glutamatergic synapses. We also examined tissue from knock-out mice to confirm the validity of the immunostaining...
  6. pmc Phosphorylation of ERK in neurokinin 1 receptor-expressing neurons in laminae III and IV of the rat spinal dorsal horn following noxious stimulation
    Erika Polgár
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Mol Pain 3:4. 2007
    ..The stimuli were mechanical (repeated pinching), thermal (immersion in water at 52 degrees C) or chemical (injection of 2% formaldehyde)...
  7. pmc Diacylglycerol kinase beta promotes dendritic outgrowth and spine maturation in developing hippocampal neurons
    Yasukazu Hozumi
    Department of Anatomy and Cell Biology, Yamagata University School of Medicine, Yamagata 990 9585, Japan
    BMC Neurosci 10:99. 2009
    ..However, it remains elusive how DGKbeta is implicated in pathophysiological role in neurons at the cellular level...
  8. ncbi request reprint Patterns of expression for the mRNA corresponding to the four isoforms of phospholipase Cbeta in mouse brain
    M Watanabe
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo, Japan
    Eur J Neurosci 10:2016-25. 1998
    ....
  9. ncbi request reprint Glial processes are glued to synapses via Ca(2+)-permeable glutamate receptors
    Masahiko Watanabe
    Dept of Anatomy, Hokkaido University School of Medicine, 060 8638, Sapporo, Japan
    Trends Neurosci 25:5-6. 2002
    ....
  10. doi request reprint Effects of FAK ablation on cerebellar foliation, Bergmann glia positioning and climbing fiber territory on Purkinje cells
    Fumihiro Watanabe
    Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Eur J Neurosci 27:836-54. 2008
    ....
  11. ncbi request reprint Molecular mechanisms governing competitive synaptic wiring in cerebellar Purkinje cells
    Masahiko Watanabe
    Department of Anatomy, Hokkaido University School of Medicine
    Tohoku J Exp Med 214:175-90. 2008
    ..Therefore, we now understand that owing to these mechanisms, territorial innervation by CFs and PFs is properly structured and mono-innervation by CFs is established. Several key issues for future study are also discussed...
  12. doi request reprint The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission
    Asami Tanimura
    Department of Neurophysiology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Neuron 65:320-7. 2010
    ..We conclude that 2-AG produced by DGLalpha, but not by DGLbeta, mediates retrograde suppression at central synapses...
  13. doi request reprint GABAergic inhibition regulates developmental synapse elimination in the cerebellum
    Hisako Nakayama
    Department of Neurophysiology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Neuron 74:384-96. 2012
    ....
  14. pmc Synapse type-independent degradation of the endocannabinoid 2-arachidonoylglycerol after retrograde synaptic suppression
    Asami Tanimura
    Department of Neurophysiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Proc Natl Acad Sci U S A 109:12195-200. 2012
    ....
  15. doi request reprint Translocation of a "winner" climbing fiber to the Purkinje cell dendrite and subsequent elimination of "losers" from the soma in developing cerebellum
    Kouichi Hashimoto
    Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Hongo, Tokyo, Japan
    Neuron 63:106-18. 2009
    ..Thus, our results suggest that the selective translocation of the winner CF to dendrites in each PC determines the single CF that survives subsequent synapse elimination and persistently innervates the PC...
  16. pmc Postsynaptic P/Q-type Ca2+ channel in Purkinje cell mediates synaptic competition and elimination in developing cerebellum
    Kouichi Hashimoto
    Department of Neurophysiology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 108:9987-92. 2011
    ..Thus, P/Q-type Ca(2+) channels in postsynaptic PCs mediate synaptic competition among multiple CFs and trigger synapse elimination in developing cerebellum...
  17. ncbi request reprint Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family
    Taisuke Miyazaki
    Department of Anatomy, Hokkaido University, School of Medicine, Sapporo, Japan
    FEBS Lett 580:4057-64. 2006
    ..Because cerebellar maturation and plasticity require metabotropic glutamate receptor signaling and resulting PKC activation, BSRPs are likely involved in ER functions supporting PKCalpha activation in PCs...
  18. pmc Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus
    Takayuki Yoshida
    Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Proc Natl Acad Sci U S A 108:3059-64. 2011
    ..These findings suggest that perisomatic inhibition by invaginating synapses is a key target of 2-AG-mediated control of the excitability of BA pyramidal neurons...
  19. ncbi request reprint Control of synaptic connection by glutamate receptor delta2 in the adult cerebellum
    Tomonori Takeuchi
    Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, and Solution Oriented Research for Science and Technology, Japan Science and Technology Agency, Tokyo 113 0033, Japan
    J Neurosci 25:2146-56. 2005
    ..We thus identified postsynaptic GluRdelta2 as a key regulator of the presynaptic active zone and PSD organization at parallel fiber-PC synapses in the adult brain...
  20. ncbi request reprint Expression and distribution of JNK/SAPK-associated scaffold protein JSAP1 in developing and adult mouse brain
    Eriko Miura
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo, Japan
    J Neurochem 97:1431-46. 2006
    ..Therefore, the characteristic cellular expression and subcellular distribution of JSAP1 might be beneficial for cells to efficiently link external stimuli to the JNK MAPK pathway and other intracellular machineries...
  21. doi request reprint IQ-ArfGEF/BRAG1 is a guanine nucleotide exchange factor for Arf6 that interacts with PSD-95 at postsynaptic density of excitatory synapses
    Hiroyuki Sakagami
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara 228 8555, Japan
    Neurosci Res 60:199-212. 2008
    ..Taken together, IQ-ArfGEF/BRAG1 forms a postsynaptic protein complex containing PSD-95 and NMDA receptors at excitatory synapses, where it may function as a GEF for Arf6...
  22. doi request reprint Ablation of glutamate receptor GluRδ2 in adult Purkinje cells causes multiple innervation of climbing fibers by inducing aberrant invasion to parallel fiber innervation territory
    Taisuke Miyazaki
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    J Neurosci 30:15196-209. 2010
    ..Thus, GluRδ2 fuels heterosynaptic competition and gives PFs the competitive advantages over CFs throughout the animal's life...
  23. doi request reprint Cav2.1 in cerebellar Purkinje cells regulates competitive excitatory synaptic wiring, cell survival, and cerebellar biochemical compartmentalization
    Taisuke Miyazaki
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    J Neurosci 32:1311-28. 2012
    ..1 KO mice. Therefore, Cav2.1 in PCs is essential for competitive synaptic wiring, cell survival, and the establishment of precise boundaries and reciprocity of biochemical compartments in PCs...
  24. doi request reprint The postsynaptic density protein, IQ-ArfGEF/BRAG1, can interact with IRSp53 through its proline-rich sequence
    Masashi Sanda
    Department of Anatomy, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Brain Res 1251:7-15. 2009
    ..Our present findings suggest that IQ-ArfGEF/BRAG1 may play roles downstream of NMDA receptors through the interaction with multivalent PSD proteins such as IRSp53 and PSD-95...
  25. ncbi request reprint Regulation of long-term depression and climbing fiber territory by glutamate receptor delta2 at parallel fiber synapses through its C-terminal domain in cerebellar Purkinje cells
    Takeshi Uemura
    Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    J Neurosci 27:12096-108. 2007
    ....
  26. doi request reprint Predominant expression of phospholipase Cbeta1 in telencephalic principal neurons and cerebellar interneurons, and its close association with related signaling molecules in somatodendritic neuronal elements
    Masahiro Fukaya
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    Eur J Neurosci 28:1744-59. 2008
    ..Furthermore, the well-orchestrated molecular arrangement appears to be the anatomical basis for the specificity, efficiency and convergence of the neuronal phosphoinositide signaling system...
  27. doi request reprint Glutamate receptor δ2 is essential for input pathway-dependent regulation of synaptic AMPAR contents in cerebellar Purkinje cells
    Miwako Yamasaki
    Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    J Neurosci 31:3362-74. 2011
    ..These results suggest that GluRδ2 is involved in a common mechanism that restricts the number of synaptic AMPARs at PF synapses in PCs and molecular layer interneurons...
  28. ncbi request reprint Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum
    Motokazu Uchigashima
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    J Neurosci 27:3663-76. 2007
    ..Thus, endocannabinoid signaling molecules are arranged to modulate the excitability of the MS neuron effectively depending on cortical activity and cholinergic tone as measured by mGluR5 and M1 receptors, respectively...
  29. ncbi request reprint Abundant distribution of TARP gamma-8 in synaptic and extrasynaptic surface of hippocampal neurons and its major role in AMPA receptor expression on spines and dendrites
    Masahiro Fukaya
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    Eur J Neurosci 24:2177-90. 2006
    ..Variable degrees of reduction further suggest that other TARPs may also mediate this function at different potencies depending on hippocampal subregions, input sources and neuronal compartments...
  30. ncbi request reprint Phospholipase Cbeta3 is distributed in both somatodendritic and axonal compartments and localized around perisynapse and smooth endoplasmic reticulum in mouse Purkinje cell subsets
    Sachi Nomura
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    Eur J Neurosci 25:659-72. 2007
    ....
  31. doi request reprint Role of the internal Shank-binding segment of glutamate receptor delta2 in synaptic localization and cerebellar functions
    Misato Yasumura
    Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Neurosci Lett 433:146-51. 2008
    ..These results suggest that the S segment and T site, the two PDZ-binding domains in the C-terminal cytoplasmic region, are differentially involved in diverse GluRdelta2 functions...
  32. doi request reprint Preferential localization of muscarinic M1 receptor on dendritic shaft and spine of cortical pyramidal cells and its anatomical evidence for volume transmission
    Miwako Yamasaki
    Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    J Neurosci 30:4408-18. 2010
    ..These molecular-anatomical arrangements will provide the evidence for volume transmission, at least in M(1)-mediated cortical cholinergic signaling...
  33. pmc Cbln1 accumulates and colocalizes with Cbln3 and GluRdelta2 at parallel fiber-Purkinje cell synapses in the mouse cerebellum
    Eriko Miura
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo, Japan
    Eur J Neurosci 29:693-706. 2009
    ..Therefore, the convergence of all three molecules provides the anatomical basis for a common signaling pathway regulating circuit development and synaptic plasticity in the cerebellum...
  34. pmc Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity
    Sho Kakizawa
    Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    EMBO J 26:1924-33. 2007
    ..Therefore, JPs support the Ca(2+)-mediated communication between voltage-gated Ca(2+) channels, RyRs and SK channels, which modulates the excitability of PCs and is fundamental to cerebellar LTD and motor functions...
  35. doi request reprint Glutamate transporters regulate lesion-induced plasticity in the developing somatosensory cortex
    Chihiro Takasaki
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    J Neurosci 28:4995-5006. 2008
    ..Considering an essential role of glutamate receptors in the formation of whisker-related thalamocortical synapse patterning, glutamate transporters thus facilitate their activity-dependent remodeling...
  36. doi request reprint Presynaptically released Cbln1 induces dynamic axonal structural changes by interacting with GluD2 during cerebellar synapse formation
    Aya Ito-Ishida
    Department of Cellular Neurobiology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Neuron 76:549-64. 2012
    ..Thus, PF protrusions triggered by Nrx-Cbln1-GluD2 signaling may promote bidirectional maturation of PF-PC synapses by a positive feedback mechanism...
  37. doi request reprint Developmental switching of perisomatic innervation from climbing fibers to basket cell fibers in cerebellar Purkinje cells
    Ryoichi Ichikawa
    Department of Anatomy, School of Medicine, Sapporo Medical University, Sapporo 060 8556, Japan
    J Neurosci 31:16916-27. 2011
    ....
  38. ncbi request reprint Localization of diacylglycerol lipase-alpha around postsynaptic spine suggests close proximity between production site of an endocannabinoid, 2-arachidonoyl-glycerol, and presynaptic cannabinoid CB1 receptor
    Takayuki Yoshida
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    J Neurosci 26:4740-51. 2006
    ..Furthermore, different fine localization within and around spines suggests that the distance between postsynaptic 2-AG production site and presynaptic CB1 is differentially controlled depending on neuron types...
  39. doi request reprint Early postnatal stress affects 5-HT1A receptor function in the medial prefrontal cortex in adult rats
    Hirokazu Matsuzaki
    Department of Neuropharmacology, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Eur J Pharmacol 615:76-82. 2009
    ....
  40. pmc Roles of phospholipase Cbeta and NMDA receptor in activity-dependent endocannabinoid release
    Yuki Hashimotodani
    Department of Cellular Neuroscience, Graduate School of Medicine, Osaka University, Suita 565 0871, Japan
    J Physiol 584:373-80. 2007
    ..The NMDA receptor and PLCbeta might play key roles in the endocannabinoid-dependent forms of STDP as coincidence detectors with different timing dependences...
  41. doi request reprint SynArfGEF is a guanine nucleotide exchange factor for Arf6 and localizes preferentially at post-synaptic specializations of inhibitory synapses
    Masahiro Fukaya
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    J Neurochem 116:1122-37. 2011
    ..Taken together, these findings suggest that synArfGEF functions as a novel regulator of Arf6 at inhibitory synapses and associates with the dystrophin-associated glycoprotein complex and S-SCAM...
  42. doi request reprint Differential interactions of cerebellin precursor protein (Cbln) subtypes and neurexin variants for synapse formation of cortical neurons
    Jae Yeol Joo
    Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 406:627-32. 2011
    ..These results suggest that Cbln subtypes exert synaptogenic activities in cortical neurons by differentially interacting with NRXN variants containing S4...
  43. ncbi request reprint Subtype switching of vesicular glutamate transporters at parallel fibre-Purkinje cell synapses in developing mouse cerebellum
    Taisuke Miyazaki
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    Eur J Neurosci 17:2563-72. 2003
    ....
  44. doi request reprint Three types of neurochemical projection from the bed nucleus of the stria terminalis to the ventral tegmental area in adult mice
    Takehiro Kudo
    Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    J Neurosci 32:18035-46. 2012
    ..VGluT2(+) and VGluT3(+) BST neurons further supply additional projections, which may principally convey excitatory or inhibitory inputs, respectively, to the VTA...
  45. ncbi request reprint Signaling complex formation of phospholipase Cbeta4 with metabotropic glutamate receptor type 1alpha and 1,4,5-trisphosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brain
    Michiko Nakamura
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    Eur J Neurosci 20:2929-44. 2004
    ..This close molecular relationship might provide PLCbeta4 with a high-fidelity effector function to mediate various neuronal responses under physiological and pathophysiological conditions...
  46. pmc Ablation of NMDA receptors enhances the excitability of hippocampal CA3 neurons
    Fumiaki Fukushima
    Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    PLoS ONE 4:e3993. 2009
    ..These results raise an intriguing possibility that hippocampal CA3 NMDA receptors may suppress the excitability of the recurrent network as a whole in vivo by restricting synchronous firing of CA3 neurons...
  47. doi request reprint Molecular and morphological configuration for 2-arachidonoylglycerol-mediated retrograde signaling at mossy cell-granule cell synapses in the dentate gyrus
    Motokazu Uchigashima
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    J Neurosci 31:7700-14. 2011
    ..This molecular-anatomical configuration will contribute to adjust network activity in the dentate gyrus after enhanced excitation...
  48. pmc Functional contributions of synaptically localized NR2B subunits of the NMDA receptor to synaptic transmission and long-term potentiation in the adult mouse CNS
    Hideki Miwa
    Division of Neuronal Network, Department of Basic Medical Sciences, Institute of Medical Science, University of Tokyo, Tokyo, 108 8639, Japan
    J Physiol 586:2539-50. 2008
    ..These results indicate that NR2B subunit-containing NMDA receptors accumulate on the synaptic site and are responsible for the unique properties of synaptic function and plasticity in the amygdala...
  49. doi request reprint IQ-ArfGEF/BRAG1 is associated with synaptic ribbons in the mouse retina
    Osamu Katsumata
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa 228 8555, Japan
    Eur J Neurosci 30:1509-16. 2009
    ..These findings indicate that IQ-ArfGEF/BRAG1 is a novel component of retinal synaptic ribbons and forms a protein complex with RIBEYE...
  50. pmc Enhancement of both long-term depression induction and optokinetic response adaptation in mice lacking delphilin
    Tomonori Takeuchi
    Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    PLoS ONE 3:e2297. 2008
    ....
  51. ncbi request reprint Depolarization-induced suppression of inhibition mediated by endocannabinoids at synapses from fast-spiking interneurons to medium spiny neurons in the striatum
    Madoka Narushima
    Department of Cellular Neuroscience, Osaka University, Graduate School of Medicine, Yamada oka, Suita 565 0871, Japan
    Eur J Neurosci 24:2246-52. 2006
    ..These results suggest that endocannabinoid-mediated retrograde suppression of inhibition influences information flow along both direct and indirect pathways, depending on the activity of MS neurons...
  52. ncbi request reprint The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynaptic sites in the hippocampus and cerebellum
    Yoshinobu Kawamura
    Department of Cellular Neuroscience, Graduate School of Medicine, Osaka University, Suita 565 0871, Japan
    J Neurosci 26:2991-3001. 2006
    ....
  53. pmc Calcium-dependent regulation of climbing fibre synapse elimination during postnatal cerebellar development
    Masanobu Kano
    Graduate School of Medicine, The University of Tokyo, Department of Neurophysiology, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Physiol 591:3151-8. 2013
    ..Thus, regulation of Ca(2+) influx to PCs through VDCCs is crucial for the four phases of CF synapse elimination during postnatal development...
  54. doi request reprint Lack of molecular-anatomical evidence for GABAergic influence on axon initial segment of cerebellar Purkinje cells by the pinceau formation
    Atsushi Iwakura
    Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    J Neurosci 32:9438-48. 2012
    ..Together, BCs do not appear to exert GABAergic synaptic inhibition on the AIS, although the mode of action of the pinceau formation remains to be explored...
  55. ncbi request reprint Distal extension of climbing fiber territory and multiple innervation caused by aberrant wiring to adjacent spiny branchlets in cerebellar Purkinje cells lacking glutamate receptor delta 2
    Ryoichi Ichikawa
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    J Neurosci 22:8487-503. 2002
    ....
  56. ncbi request reprint NR2 to NR3B subunit switchover of NMDA receptors in early postnatal motoneurons
    Masahiro Fukaya
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    Eur J Neurosci 21:1432-6. 2005
    ..Therefore, the major regulatory subunit of NMDA receptors is likely to switch from NR2 to NR3B in somatic motoneurons during the early postnatal period...
  57. ncbi request reprint Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum
    Mikio Hoshino
    Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Neuron 47:201-13. 2005
    ..Our results suggest that Ptf1a is involved in driving neural precursors to differentiate into GABAergic neurons in the cerebellum...
  58. doi request reprint Inositol 1,4,5-trisphosphate signaling maintains the activity of glutamate uptake in Bergmann glia
    Masato Mashimo
    Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Eur J Neurosci 32:1668-77. 2010
    ..These results suggest that the IP(3) signaling cascade is involved in regulating GLAST levels in BGs to maintain glutamate clearance in the mature cerebellum...
  59. ncbi request reprint P/Q-type Ca2+ channel alpha1A regulates synaptic competition on developing cerebellar Purkinje cells
    Taisuke Miyazaki
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    J Neurosci 24:1734-43. 2004
    ..This molecular function facilitates the distal extension of climbing fiber innervation along the dendritic tree of the Purkinje cell and also establishes climbing fiber monoinnervation of individual Purkinje cells...
  60. pmc Use-dependent amplification of presynaptic Ca2+ signaling by axonal ryanodine receptors at the hippocampal mossy fiber synapse
    Hidemi Shimizu
    Departments of Anatomy and Neurobiology, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    Proc Natl Acad Sci U S A 105:11998-2003. 2008
    ....
  61. ncbi request reprint Evidence against GABA release from glutamatergic mossy fiber terminals in the developing hippocampus
    Motokazu Uchigashima
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    J Neurosci 27:8088-100. 2007
    ..Hippocampal mossy fiber terminals synthesize and store GABA, but have limited ability in vesicular release for GABA in the developing rodents...
  62. pmc Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins
    Shigeki Moriguchi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Graduate School of Medicine, Tohoku University, Sendai 980, Japan
    Proc Natl Acad Sci U S A 103:10811-6. 2006
    ..Therefore, JPs seem to have an essential role in neural excitability fundamental to plasticity and integrated functions...
  63. ncbi request reprint Tonic enhancement of endocannabinoid-mediated retrograde suppression of inhibition by cholinergic interneuron activity in the striatum
    Madoka Narushima
    Department of Cellular Neuroscience, Osaka University, Graduate School of Medicine, Yamada oka, Suita 565 0871, Japan
    J Neurosci 27:496-506. 2007
    ..Thus, we have disclosed a novel mechanism by which the muscarinic system regulates striatal output and may contribute to motor control...
  64. ncbi request reprint Distinct expression of Cbln family mRNAs in developing and adult mouse brains
    Eriko Miura
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    Eur J Neurosci 24:750-60. 2006
    ..These results will provide a molecular-anatomical basis for future studies that characterize roles played by the Cbln family...
  65. doi request reprint Distinct synaptic localization patterns of brefeldin A-resistant guanine nucleotide exchange factors BRAG2 and BRAG3 in the mouse retina
    Hiroyuki Sakagami
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa 252 0374, Japan
    J Comp Neurol 521:860-76. 2013
    ..These findings suggest that BRAG/IQSEC family members have key roles in the function and organization of distinct excitatory and inhibitory synapses in the retina...
  66. doi request reprint Type 2 K+ -Cl- cotransporter is preferentially recruited to climbing fiber synapses during development and the stellate cell-targeting dendritic zone at adulthood in cerebellar Purkinje cells
    Issei Kawakita
    Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo, 060 8638, Japan
    Eur J Neurosci 37:532-43. 2013
    ....
  67. doi request reprint Distinct neurochemical and functional properties of GAD67-containing 5-HT neurons in the rat dorsal raphe nucleus
    Hiroki Shikanai
    Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    J Neurosci 32:14415-26. 2012
    ..These findings indicate that 5-HT/GAD67 neurons constitute a unique neuronal population with distinctive neurochemical and electrophysiological properties and high responsiveness to innocuous stressor...
  68. pmc TRIM67 protein negatively regulates Ras activity through degradation of 80K-H and induces neuritogenesis
    Hiroaki Yaguchi
    Department of Biochemistry, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060 8638, Japan
    J Biol Chem 287:12050-9. 2012
    ..These findings suggest that TRIM67 regulates Ras signaling via degradation of 80K-H, leading to neural differentiation including neuritogenesis...
  69. pmc Nitric oxide-induced calcium release via ryanodine receptors regulates neuronal function
    Sho Kakizawa
    Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    EMBO J 31:417-28. 2012
    ..These findings suggest that NICR via RyR1 plays a regulatory role in the physiological and pathophysiological functions of the brain...
  70. pmc Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice
    Masahiro Fukaya
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    Proc Natl Acad Sci U S A 100:4855-60. 2003
    ....
  71. doi request reprint Cytochemical and cytological properties of perineuronal oligodendrocytes in the mouse cortex
    Chihiro Takasaki
    Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Eur J Neurosci 32:1326-36. 2010
    ....
  72. pmc Postsynaptic GABAB receptor signalling enhances LTD in mouse cerebellar Purkinje cells
    Yuji Kamikubo
    Department of Cellular Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    J Physiol 585:549-63. 2007
    ..Furthermore, pharmacological inhibition of GABABR reduced the magnitude of LTD at parallel fibre-Purkinje cell synapses in cerebellar slices. These findings demonstrate a novel mechanism that would facilitate cerebellar motor learning...
  73. ncbi request reprint Segmental and complementary expression of L-serine biosynthetic enzyme 3-phosphoglycerate dehydrogenase and neutral amino acid transporter ASCT1 in the mouse kidney
    Chihiro Takasaki
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    Biomed Res 28:61-9. 2007
    ..e., the distal tubule and collecting duct. Therefore, either Phgdh or ASCT1 is provided to each segment of renal tubules, suggesting that metabolic interplay mediated by L-serine biosynthesis and supply may exist in the kidney too...
  74. ncbi request reprint Neutral amino acid transporter ASCT1 is preferentially expressed in L-Ser-synthetic/storing glial cells in the mouse brain with transient expression in developing capillaries
    Kazuhisa Sakai
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    J Neurosci 23:550-60. 2003
    ..Therefore, ASCT1 appears to be regulated to meet metabolic demands by differentiating and mature neurons through the transport of glia- and blood-borne small neutral amino acids...
  75. doi request reprint Retrieval of conditioned fear activates the basolateral and intercalated nucleus of amygdala
    Takeshi Izumi
    Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Neurosci Res 89:773-90. 2011
    ..It is therefore speculated that ITC GABAergic neurons were activated by retrieval of conditioned fear and that transcription factors other than c-Fos were relevant to the activation...
  76. pmc Imaging extrasynaptic glutamate dynamics in the brain
    Yohei Okubo
    Departments of Pharmacology and Neurobiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 107:6526-31. 2010
    ..Thus, the present study clarifies the spatiotemporal features of extrasynaptic glutamate dynamics, and opens up an avenue to directly visualizing synaptic activity in live animals...
  77. doi request reprint Striatal direct pathway modulates response time in execution of visual discrimination
    Ryoji Fukabori
    Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima 960 1295, Japan
    Eur J Neurosci 35:784-97. 2012
    ..The restoration of motor response deficits during repetitive sessions suggests the presence of a mechanism by which the response facilitation is acquired through continuation of learning despite the removal of the striatonigral pathway...
  78. pmc NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity
    Takanobu Nakazawa
    Division of Oncology, Department of Cancer Biology, University of Tokyo, Tokyo, Japan
    EMBO J 25:2867-77. 2006
    ..We thus identify Tyr-1472 phosphorylation as a key mediator of fear learning and amygdaloid synaptic plasticity...
  79. doi request reprint Cellular expression and subcellular localization of secretogranin II in the mouse hippocampus and cerebellum
    Taisuke Miyazaki
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo, Japan
    Eur J Neurosci 33:82-94. 2011
    ..The wide subcellular localization of SgII may reflect diverse release sites of neuropeptides and secretorneurin, or suggests its role in the sorting and packaging of molecules other than neuropeptides in non-LDCV compartments...
  80. ncbi request reprint Spatial diversity in gene expression for VDCCgamma subunit family in developing and adult mouse brains
    Masahiro Fukaya
    Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Neurosci Res 53:376-83. 2005
    ..Therefore, the present study has revealed spatial diversity in gene expression for individual VDCCgamma subunits, presumably reflecting functional diversity of this protein family and their differential involvement in neural function...
  81. doi request reprint Cerebellar pathology in transgenic mice expressing the pseudorabies virus immediate-early protein IE180
    Yukiko Tomioka
    Laboratory of Animal Experiment for Disease Model, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Eur J Neurosci 27:2115-32. 2008
    ....
  82. ncbi request reprint Early postnatal stress affects the serotonergic function in the median raphe nuclei of adult rats
    Kohtarou Konno
    Department of Neuropharmacology, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Sapporo, Japan
    Brain Res 1172:60-6. 2007
    ..In other words, the "critical period" appears to be the time of neural circuit development of the MRN serotonergic system, which may be implicated in lifelong susceptibility to emotional stress...
  83. pmc VAV2 and VAV3 as candidate disease genes for spontaneous glaucoma in mice and humans
    Keiko Fujikawa
    Department of Pathology and Immunology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    PLoS ONE 5:e9050. 2010
    ..Nonetheless, the mechanism of its pathogenesis has not been well-elucidated, particularly at the molecular level, because of insufficient availability of experimental genetic animal models...
  84. ncbi request reprint Changes of high-affinity choline transporter CHT1 mRNA expression during degeneration and regeneration of hypoglossal nerves in mice
    Shohei Oshima
    Department of Pediatric Dentistry, Hokkaido University School of Dentistry, Sapporo 060 8586, Japan
    Neurosci Lett 365:97-101. 2004
    ..These results suggest that the establishment of motor innervation is critical for CHT1 mRNA expression in hypoglossal neurons after axotomy...
  85. ncbi request reprint Early onset of NMDA receptor GluR epsilon 1 (NR2A) expression and its abundant postsynaptic localization in developing motoneurons of the mouse hypoglossal nucleus
    Shohei Oshima
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    Neurosci Res 43:239-50. 2002
    ....
  86. ncbi request reprint Cellular distribution of glutamate transporters in the gastrointestinal tract of mice: an immunohistochemical and in situ hybridization approach
    Toshihiko Iwanaga
    Department of Anatomy, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo 060 8638, Japan
    Biomed Res 26:271-8. 2005
    ..The strong and specific luminal localization of EAAC1 in the intestinal epithelium suggests that EAAC1 is a predominant transporter of glutamate, at least in the lower part of the small intestine...
  87. ncbi request reprint Cytodifferentiation of Bergmann glia and its relationship with Purkinje cells
    Keiko Yamada
    Department of Anatomy, Hokkaido University School of Medicine, N15 W7, Kita ku, Sapporo 060 8638, Japan
    Anat Sci Int 77:94-108. 2002
    ..The functional relevance of this intimate neuron-glial relationship is also discussed with reference to recent studies in cell biology, cell ablation and gene knockout...
  88. doi request reprint Reduction of bone cancer pain by activation of spinal cannabinoid receptor 1 and its expression in the superficial dorsal horn of the spinal cord in a murine model of bone cancer pain
    Shingo Furuse
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan
    Anesthesiology 111:173-86. 2009
    ..This study examined whether selective spinal cannabinoid receptor 1 (CB1) activation alleviates bone cancer pain and also examined the spinal expression of CB1...
  89. ncbi request reprint Identification and characterization of a novel member of murine semaphorin family
    Masahiko Taniguchi
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Genes Cells 10:785-92. 2005
    ....
  90. ncbi request reprint Selective expression of L-serine synthetic enzyme 3PGDH in schwann cells, perineuronal glia, and endoneurial fibroblasts along rat sciatic nerves and its upregulation after crush injury
    Noboru Yamashita
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo, Japan
    Arch Histol Cytol 66:429-36. 2003
    ....
  91. ncbi request reprint Characterization of a novel low-molecular-mass dual specificity phosphatase-4 (LDP-4) expressed in brain
    Kentaro Takagaki
    Division of Biochemical Oncology and Immunology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo, Japan
    Mol Cell Biochem 296:177-84. 2007
    ..When expressed in COS-7 cells, FLAG-tagged LDP-4 protein was present within the nucleus and Golgi apparatus. LDP-4 expression did not reduce phosphorylation levels of MAPKs, but rather evoked activation of JNK and p38...
  92. ncbi request reprint Widespread expression of the AMPA receptor GluR2 subunit at glutamatergic synapses in the rat spinal cord and phosphorylation of GluR1 in response to noxious stimulation revealed with an antigen-unmasking method
    Gergely G Nagy
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    J Neurosci 24:5766-77. 2004
    ..This finding demonstrates plastic changes, presumably contributing to central sensitization, at the synaptic level...
  93. ncbi request reprint Upregulation of GluR2 decreases intracellular Ca2+ following ischemia in developing gerbils
    Keiji Oguro
    Department of Surgical Neurology, Jichi Medical School, Minamikawachi Machi, Tochigi 329 0498, Japan
    Neurosci Lett 364:101-5. 2004
    ..These results suggest that the higher expression of GluR2 is important for the smaller increases in [Ca2+]i and enhanced resistance to ischemia-induced neuronal damage in developing animals...
  94. pmc CD3 and immunoglobulin G Fc receptor regulate cerebellar functions
    Kazuhiro Nakamura
    Department of Pathology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Mol Cell Biol 27:5128-34. 2007
    ..In the two knockout mice, enhanced paired-pulse facilitation of parallel fiber-Purkinje cell synapses was shared. These results indicate that diverse immune molecules play critical roles in the functional establishment in the cerebellum...
  95. ncbi request reprint Mammalian septin Sept2 modulates the activity of GLAST, a glutamate transporter in astrocytes
    Nagatoki Kinoshita
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Genes Cells 9:1-14. 2004
    ..Thus Sept2 may regulate GLAST-mediated glutamate uptake by astrocytes, which is important for appropriate transmitter signalling in the cerebellum...
  96. doi request reprint Cbln1 regulates rapid formation and maintenance of excitatory synapses in mature cerebellar Purkinje cells in vitro and in vivo
    Aya Ito-Ishida
    Department of Physiology, School of Medicine, Keio University, Tokyo 160 8582, Japan
    J Neurosci 28:5920-30. 2008
    ..Furthermore, our results indicate that Cbln1 can also rapidly organize new synapses in adult cerebellum, implying its therapeutic potential for cerebellar ataxic disorders...
  97. ncbi request reprint Role of thalamic phospholipase C[beta]4 mediated by metabotropic glutamate receptor type 1 in inflammatory pain
    Mariko Miyata
    Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki 444 8585, Japan
    J Neurosci 23:8098-108. 2003
    ..These findings indicate that the thalamic mGluR1-PLCbeta4 cascade is indispensable for the formalin-induced inflammatory pain by regulating the response of VPL neurons...
  98. ncbi request reprint Molecular cloning and identification of 3'-phosphoadenosine 5'-phosphosulfate transporter
    Shin Kamiyama
    Division of Cell Biology, Soka University, 1 236 Tangi cho, Hachioji, Tokyo 192 8577, Japan
    J Biol Chem 278:25958-63. 2003
    ..It is well known that mutations of some genes related to PAPS synthesis are responsible for human inherited disorders. Our findings provide insights into the significance of PAPS transport and post-translational sulfation...
  99. ncbi request reprint Complementary stripes of phospholipase Cbeta3 and Cbeta4 expression by Purkinje cell subsets in the mouse cerebellum
    Justyna R Sarna
    Department of Cell Biology and Anatomy, Genes and Development Research Group, Faculty of Medicine, The University of Calgary, Alberta, Canada
    J Comp Neurol 496:303-13. 2006
    ..These nonoverlapping expression patterns suggest that long-term depression may be manifested differently between cerebellar modules...
  100. doi request reprint Enzymatic machinery for endocannabinoid biosynthesis associated with calcium stores in glutamatergic axon terminals
    Rita Nyilas
    Institute of Experimental Medicine, Hungarian Academy of Sciences, H 1083 Budapest, Hungary
    J Neurosci 28:1058-63. 2008
    ....
  101. ncbi request reprint Genetic ablation of NMDA receptor subunit NR3B in mouse reveals motoneuronal and nonmotoneuronal phenotypes
    Stephan Niemann
    RIKEN MIT Neuroscience Research Center, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Eur J Neurosci 26:1407-20. 2007
    ..This work is the first reporting of the functional significance of NR3B in vivo and may give insight into the contribution of genetic variability of NR3B in the phenotypic heterogeneity among human population...