S Todo

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. pmc Analysis of the risk factors for early death due to disease recurrence or progression within 1 year after hepatectomy in patients with hepatocellular carcinoma
    Toshiya Kamiyama
    The Department of General Surgery, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo, 060 8638, Japan
    World J Surg Oncol 10:107. 2012
  2. pmc N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma
    Takeaki Kudo
    Department of General Surgery, Graduate School of Medicine, Hokkaido University, Japan
    Mol Cancer 6:32. 2007
  3. pmc Swainsonine reduces 5-fluorouracil tolerance in the multistage resistance of colorectal cancer cell lines
    Jun Hamaguchi
    Department of General Surgery, Graduate School of Medicine, Hokkaido University, Sapporo 060 8638, Japan
    Mol Cancer 6:58. 2007
  4. ncbi request reprint How to prevent and manage biliary complications in living donor liver transplantation?
    Satoru Todo
    The First Department of Surgery, Hokkaido University School of Medicine, N 15, W 7, Kita ku, Sapporo 060 8638, Japan
    J Hepatol 43:22-7. 2005
  5. ncbi request reprint Extending indication: role of living donor liver transplantation for hepatocellular carcinoma
    Satoru Todo
    Department of General Surgery, Hokkaido University Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Liver Transpl 13:S48-54. 2007
  6. pmc Living donor liver transplantation for adult patients with hepatocellular carcinoma: experience in Japan
    Satoru Todo
    First Department of Surgery, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Ann Surg 240:451-9; discussion 459-61. 2004
  7. ncbi request reprint Living donor liver transplantation in adults: outcome in Japan
    S Todo
    First Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan
    Liver Transpl 6:S66-72. 2000
  8. ncbi request reprint Attenuation of ischemia and reperfusion injury of canine livers by inhibition of type II phospholipase A2 with LY329722
    K Ogata
    First Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan
    Transplantation 71:1040-6. 2001
  9. ncbi request reprint Comparison between prenatally diagnosed choledochal cyst and type-1 cystic biliary atresia by CD56-immunostaining using liver biopsy specimens
    T Okada
    Department of Pediatric Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Eur J Pediatr Surg 17:6-11. 2007
  10. ncbi request reprint Correlation between elevated intratumoral thymidine phosphorylase and prognosis of node-positive breast carcinoma undergoing adjuvant doxifluridine treatment
    H Takahashi
    First Department of Surgery, Hokkaido University School of Medicine, Kita ku, Sapporo 060 8638, Japan
    Int J Oncol 17:1205-11. 2000

Collaborators

Detail Information

Publications108 found, 100 shown here

  1. pmc Analysis of the risk factors for early death due to disease recurrence or progression within 1 year after hepatectomy in patients with hepatocellular carcinoma
    Toshiya Kamiyama
    The Department of General Surgery, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo, 060 8638, Japan
    World J Surg Oncol 10:107. 2012
    ..Moreover, it has been reported that some patients with HCC have an early death due to recurrence. We analyzed the preoperative risk factors for early cancer death...
  2. pmc N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma
    Takeaki Kudo
    Department of General Surgery, Graduate School of Medicine, Hokkaido University, Japan
    Mol Cancer 6:32. 2007
    ..Although multiple mechanisms likely underlie resistance of cancer cells to anticancer drugs, including overexpression of transporters, the relationship of glycans to drug resistance is not well understood...
  3. pmc Swainsonine reduces 5-fluorouracil tolerance in the multistage resistance of colorectal cancer cell lines
    Jun Hamaguchi
    Department of General Surgery, Graduate School of Medicine, Hokkaido University, Sapporo 060 8638, Japan
    Mol Cancer 6:58. 2007
    ..However, a number of resistance mechanisms have been reported and are thought to be the reason for the difficulties in solving drug-resistance problems...
  4. ncbi request reprint How to prevent and manage biliary complications in living donor liver transplantation?
    Satoru Todo
    The First Department of Surgery, Hokkaido University School of Medicine, N 15, W 7, Kita ku, Sapporo 060 8638, Japan
    J Hepatol 43:22-7. 2005
  5. ncbi request reprint Extending indication: role of living donor liver transplantation for hepatocellular carcinoma
    Satoru Todo
    Department of General Surgery, Hokkaido University Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Liver Transpl 13:S48-54. 2007
    ..Indication of hepatocellular carcinoma. Milan criteria. United Network for Organ Sharing (UNOS) tumor staging. Alfa-fetoprotein (AFP). Protein induced by vitamin K absence or antagonism factor II (PIVKA II)...
  6. pmc Living donor liver transplantation for adult patients with hepatocellular carcinoma: experience in Japan
    Satoru Todo
    First Department of Surgery, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Ann Surg 240:451-9; discussion 459-61. 2004
    ..We sought to determine the outcome of living donor liver transplantation (LDLTx) in 316 adult patients with hepatocellular carcinoma (HCC)...
  7. ncbi request reprint Living donor liver transplantation in adults: outcome in Japan
    S Todo
    First Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan
    Liver Transpl 6:S66-72. 2000
    ..9%). Survival was not influenced by the type of graft. 3. There were no donor deaths (0%); 9.3% of donors experienced mild to moderate complications. Biliary complications were the most frequent. 4. Overall recipient survival was 72.4%...
  8. ncbi request reprint Attenuation of ischemia and reperfusion injury of canine livers by inhibition of type II phospholipase A2 with LY329722
    K Ogata
    First Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan
    Transplantation 71:1040-6. 2001
    ..CONCLUSION: The present study demonstrated that a type II PLA2 inhibitor, LY329722, attenuated hepatic I/R injury caused by a 2-hr THVE model in dogs...
  9. ncbi request reprint Comparison between prenatally diagnosed choledochal cyst and type-1 cystic biliary atresia by CD56-immunostaining using liver biopsy specimens
    T Okada
    Department of Pediatric Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Eur J Pediatr Surg 17:6-11. 2007
    ....
  10. ncbi request reprint Correlation between elevated intratumoral thymidine phosphorylase and prognosis of node-positive breast carcinoma undergoing adjuvant doxifluridine treatment
    H Takahashi
    First Department of Surgery, Hokkaido University School of Medicine, Kita ku, Sapporo 060 8638, Japan
    Int J Oncol 17:1205-11. 2000
    ..0446; overall survival, p=0.0788). Intratumoral dThdPase activity might be a useful marker for predicting responsiveness to doxifluridine treatment in the adjuvant setting...
  11. ncbi request reprint Three-dimensional volumetric analysis for reconstruction of middle hepatic vein tributaries in living donor liver transplantation
    Maeng Bong Jin
    Hokkaido University, Graduate School of Medicine, Sapporo, Japan
    J Am Coll Surg 200:468-9. 2005
  12. doi request reprint Three-dimensional computed tomography scan analysis of hepatic vasculatures in the donor liver for living donor liver transplantation
    Koichiro Uchida
    Department of General Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Liver Transpl 16:1062-8. 2010
    ..Therefore, anatomical and volumetric analysis is important for preoperative evaluations...
  13. doi request reprint A human anti-CD40 monoclonal antibody, 4D11, for kidney transplantation in cynomolgus monkeys: induction and maintenance therapy
    T Aoyagi
    First Department of Surgery, Hokkaido University School of Medicine, Sapporo, Hokkaido, Japan
    Am J Transplant 9:1732-41. 2009
    ..These results indicate that the 4D11 appears to be a promising candidate for immunosuppression in clinical organ transplantation...
  14. ncbi request reprint Microbial flora alterations in jejunum and colon after chemical bowel preparation before Kasai hepatoportojejunostomy
    T Okada
    Department of Pediatric Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Eur J Pediatr Surg 17:304-7. 2007
    ....
  15. ncbi request reprint [Liver transplantation for patients with hepatitis B/C virus cirrhosis or hepato cellular carcinoma]
    Satoru Todo
    Hokkaido University School of Medicine, Department of General Surgery
    Nihon Geka Gakkai Zasshi 103:408-13. 2002
    ..In addition, to expand the current limited transplant indications for HCC, the efficacy of perioperative anticancer treatment and the importance of molecular diagnosis of circulating hepatoma cells must be determined in future...
  16. doi request reprint Long-term hepatic allograft acceptance based on CD40 blockade by ASKP1240 in nonhuman primates
    T Oura
    Department of General Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Am J Transplant 12:1740-54. 2012
    ..No serious side effects, including thromboembolic complications, were noted in the ASKP1240-treated monkeys. We conclude that CD40 blockade by ASKP1240 would be a desirable immunosuppressant for clinical liver transplantation...
  17. ncbi request reprint Management of childhood and adolescent thyroid carcinoma: long-term follow-up and clinical characteristics
    T Okada
    Department of Pediatric Surgery, Hokkaido University Graduate School of Medicine, Nishi, Sapporo, Japan
    Eur J Pediatr Surg 16:8-13. 2006
    ..This analysis was performed to evaluate clinical factors such as local tumor control, control of distant metastasis, survival, and complications in children and adolescents with thyroid carcinoma...
  18. ncbi request reprint Effective fluconazole therapy for liver transplant recipients during continuous hemodiafiltration
    S Kishino
    Department of Pharmacy, Hokkaido University Hospital, Hokkaido University, Sapporo, Japan
    Ther Drug Monit 23:4-8. 2001
    ..To guarantee safe and effective fluconazole therapy, the trough levels should be monitored routinely during CHDF...
  19. doi request reprint Alveolar echinococcosis of the liver in children
    Tadashi Yoshida
    Department of Digestive and General Surgery, Hokkaido University Graduate School of Medicine, Kita ku, Kita 15, Nishi 7, Sapporo 060 8638, Japan
    J Hepatobiliary Pancreat Sci 17:152-7. 2010
    ..Alveolar echinococcosis of the liver (AEL) is a zoonosis that is distributed in cold regions of the northern hemisphere. The disease is mostly found in adults and rarely in pediatric patients because it tends to be slow growing...
  20. doi request reprint ASKP1240, a Fully Human Anti-CD40 Monoclonal Antibody, Prolongs Pancreatic Islet Allograft Survival in Nonhuman Primates
    M Watanabe
    First Department of Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Am J Transplant 13:1976-88. 2013
    ..ASKP1240 appears to be a promising candidate for immunosuppression in clinical PITx. ..
  21. pmc Luminal membrane expression of mesothelin is a prominent poor prognostic factor for gastric cancer
    T Einama
    Department of General Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Br J Cancer 107:137-42. 2012
    ..In this study, we examined the clinicopathological significance of the mesothelin expression in gastric cancer, especially in terms of its association with the staining pattern...
  22. ncbi request reprint Histological differentiation between prenatally diagnosed choledochal cyst and type I cystic biliary atresia using liver biopsy specimens
    T Okada
    Department of Pediatric Surgery, First Surgery, Hokkaido University School of Medicine, Nidhi, Sapporo, Japan
    Eur J Pediatr Surg 16:28-33. 2006
    ....
  23. ncbi request reprint Protective effect of agiotensin II type I receptor antagonist, CV-11974, on ischemia and reperfusion injury of the liver
    H Masuko
    First Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan
    Transplantation 71:1034-9. 2001
    ..CONCLUSIONS: Our data demonstrated that the local renin-angiotensin system might play a role in hepatic microcirculation. AT1 receptor blockade with CV-11974 attenuated hepatic microcirculatory disturbance and ameliorated I/R injury...
  24. ncbi request reprint Cystic thymoma in a child: a rare case and review of the literature
    S Honda
    Department of Pediatric Surgery, Hokkaido University Graduate School of Medicine, Kita ku, Kita 15, Nishi 7, Sapporo, 060 8638, Japan
    Pediatr Surg Int 23:1015-7. 2007
    ..The microscopic findings were characteristic of cystic thymoma. The literature on cystic thymoma is reviewed here and the clinical characteristics of cystic thymoma are discussed...
  25. ncbi request reprint Induction of macrophage migration inhibitory factor by lysophosphatidic acid: relevance to tumor growth and angiogenesis
    Bailong Sun
    Department of Surgery, Hokkaido University Graduate School of Medicine, N15 W7, Kita ku, Sapporo 060 8638, Japan
    Int J Mol Med 12:633-41. 2003
    ..Taken together, these results suggest that MIF could promote both tumor cell growth and angiogenesis induced by LPA via both the Ras-MAPK and Ras-Akt/PI3K signaling pathways...
  26. ncbi request reprint E1AF expression is closely correlated with malignant phenotype of tongue squamous cell carcinoma through activation of MT1-MMP gene promoters
    Yuri Izumiyama
    Department of Oral Pathobiological Science, Hokkaido University Graduate School of Dental Medicine, N13 W7, Kita ku, Sapporo 060 8586, Japan
    Oncol Rep 13:715-20. 2005
    ..These results indicate that E1AF positively regulates transcription from MT1-MMP genes, which plays an important role in invasion and metastasis of squamous cell carcinoma of the tongue by converting pro-MMP-2 into active-MMP-2...
  27. ncbi request reprint Induction of donor-specific tolerance by adenovirus-mediated CD40Ig gene therapy in rat liver transplantation
    Masaru Nomura
    First Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan
    Transplantation 73:1403-10. 2002
    ..Seeking for simple and effective approach to interfere this signaling, we applied adenovirus-mediated gene therapy by encoding CD40Ig gene (AdCD40Ig)...
  28. ncbi request reprint Transduction of exogenous constitutively activated Stat3 into dispersed islets induces proliferation of rat pancreatic beta-cells
    Shusaku Tsukiyama
    First Department of Surgery, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Tissue Eng 12:131-40. 2006
    ..Stat3-C induced cell proliferation of beta-cells without loss of insulin secretion activity at the glucose challenge, and HGF enhanced the beta-cell proliferative activity of Stat3-C...
  29. ncbi request reprint Evolution of immunosuppression in liver transplantation: contribution of cyclosporine
    H Furukawa
    Department of Organ Transplantation and Regenerative Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    Transplant Proc 36:274S-284S. 2004
    ..In addition, details are provided on the newer immunosuppressive agents: mycophenolate mofetil, sirolimus, and the IL-2 receptor antagonists, as well as agents in development: CAMPATH 1-H, thymoglobulin, everolimus, FT720, and FK778...
  30. ncbi request reprint Does the permanent portacaval shunt for a small-for-size graft in a living donor liver transplantation do more harm than good?
    T Oura
    Department of General Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Am J Transplant 8:250-2. 2008
    ..This experience indicates that the portacaval shunt would overcome SFSGS in the early period of LDLT, while it would cause the graft atrophy and the graft dysfunction in the late period of LDLT...
  31. pmc A phase I trial of cytotoxic T-lymphocyte precursor-oriented peptide vaccines for colorectal carcinoma patients
    Y Sato
    First Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan
    Br J Cancer 90:1334-42. 2004
    ..One patient was found to have a partial response; another had a stable disease, sustained through 6 months. These results encourage further development of CTL precursor-oriented vaccine for colorectal cancer patients...
  32. ncbi request reprint Perforation of the piriform recessus by a swallowed glass splinter presenting as pneumomediastinum in a child
    T Okada
    Department of Pediatric Surgery, Hokkaido University School of Medicine, Kita ku, Kita 15, Nishi 7, 060 8638 Sapporo, Japan
    Pediatr Surg Int 20:643-5. 2004
    ..The literature on such injuries is reviewed here, and the problems associated with treating children with perforation of the piriform recessus and mediastinitis caused by swallowed glass splinters are discussed...
  33. ncbi request reprint Delay of gastric emptying measured by 13C-acetate breath test in neurologically impaired children with gastroesophageal reflux
    T Okada
    Department of Pediatric Surgery, Third Internal Medicine, Endoscopy, First Surgery, Hokkaido University School of Medicine, Sapporo, Japan
    Eur J Pediatr Surg 15:77-81. 2005
    ..0045). Gastric emptying studies can be easily and reliably carried out in children with NI using (13)C- ABT. We showed that we were able to determine the gastric emptying rate by (13)C- ABT in patients with GER due to NI...
  34. ncbi request reprint [Effects of pharmacokinetic modulation chemotherapy (PMC) using oral UFT and venous 5-FU infusion as adjuvant chemotherapy for intrahepatic cholangiocellular carcinoma]
    Hideki Yokoo
    Department of General Surgery, Hokkaido University Graduate School of Medicine
    Gan To Kagaku Ryoho 36:2400-3. 2009
    ..Intrahepatic cholangiocellular carcinoma after curative surgery was treated with pharmacokinetic modulation chemotherapy (PMC) as adjuvant chemotherapy...
  35. ncbi request reprint Living-donor liver transplantation for hepatocellular carcinoma
    Hiroyuki Furukawa
    Department of Organ Transplantation and Regenerative Medicine, Hokkaido University School of Medicine, N 15 W 7, Kita ku, Sapporo, 060 8646, Japan
    J Hepatobiliary Pancreat Surg 13:393-7. 2006
    ..Identification of a noninvasive marker that could predict the biological behavior as well as the prognosis of HCC would indeed be a major breakthrough...
  36. ncbi request reprint Hepatopulmonary fistula caused by alveolar echinococcosis: report of a case
    Tatsuhiko Kakisaka
    Department of General Surgery, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo 060 8638, Japan
    Surg Today 36:937-40. 2006
    ..We report this case to emphasize that the first-line treatment for a hepatopulmonary fistula caused by HAE should be radical surgery, which results in relief of symptoms and a good outcome...
  37. pmc AFP mRNA detected in bone marrow by real-time quantitative RT-PCR analysis predicts survival and recurrence after curative hepatectomy for hepatocellular carcinoma
    Toshiya Kamiyama
    Department of General Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Ann Surg 244:451-63. 2006
    ..To determine whether detection of hepatocellular carcinoma (HCC) cells by real-time quantitative RT-PCR targeting of alpha-fetoprotein mRNA (AFP mRNA) before or after curative hepatectomy predicts HCC recurrence and patient survival...
  38. ncbi request reprint A nomogram for predicting the optimal oral dosage of tacrolimus in liver transplant recipients with small-for-size grafts
    Satoshi Kishino
    Department of Medication Use Analysis and Clinical Research, Meiji Pharmaceutical University, Tokyo, and First Department of Surgery, Hokkaido University Hospital, Sapporo, Japan
    Clin Transplant 20:443-9. 2006
    ..The nomogram that we have constructed, based on graft size (GV/SV ratio), will easily provide optimal dose for each patient with small-for-size graft in the early postoperative period...
  39. doi request reprint Management and outcome in prenatally diagnosed sacrococcygeal teratomas
    Tadao Okada
    Department of Pediatric Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Pediatr Int 50:576-80. 2008
    ..The aim of the present study was to retrospectively determine the clinical factors affecting the outcome after birth in prenatally diagnosed sacrococcygeal teratomas (SCT)...
  40. ncbi request reprint Impact of double-filtration plasmapheresis in combination with interferon and ribavirin in living donor liver transplant recipients with hepatitis C
    Masahiko Taniguchi
    Department of General Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Transplantation 81:1747-9. 2006
    ..DFPP appeared to be effective in reducing HCV viremia and preventing HCV recurrence in patients with high HCV RNA levels after LDLT. Moreover, it may become a rescue therapy for FCH in a liver transplant recipient with hepatitis C...
  41. doi request reprint Idiopathic thrombocytopenic purpura complicated with biliary atresia: a rare occurrence and literature review
    Tadao Okada
    Department of Pediatric Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Pediatr Surg 44:e21-3. 2009
    ..We review the literature on this type of relationship between BA and ITP and discuss the clinical features of this complication. Furthermore, the possible cause of the onset of ITP complicated with BA was explored in this report...
  42. doi request reprint Recurrence patterns after hepatectomy of hepatocellular carcinoma: implication of Milan criteria utilization
    Toshiya Kamiyama
    Department of General Surgery, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Ann Surg Oncol 16:1560-71. 2009
    ..Bridge hepatectomy followed by salvage liver transplantation has been proposed for patients with hepatocellular carcinoma (HCC) and preserved liver function...
  43. doi request reprint Perioperative management of hepatic resection toward zero mortality and morbidity: analysis of 793 consecutive cases in a single institution
    Toshiya Kamiyama
    Department of General Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Am Coll Surg 211:443-9. 2010
    ..The mortality rates associated with hepatectomy are still not zero. Our aim was to define the risk factors for complications and to evaluate our perioperative management...
  44. ncbi request reprint Immunological evaluation of personalized peptide vaccination in combination with a 5-fluorouracil derivative (TS-1) for advanced gastric or colorectal carcinoma patients
    Yuji Sato
    Department of General Surgery, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Cancer Sci 98:1113-9. 2007
    ....
  45. doi request reprint Usefulness of axial planes of helical computed tomography for diagnosis of pancreaticobiliary maljunction in early infants with negative findings on magnetic resonance cholangiopancreatography
    Tadao Okada
    Department of Pediatric Surgery, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    J Pediatr Surg 43:579-82. 2008
    ....
  46. doi request reprint The impact of anatomical resection for hepatocellular carcinoma that meets the Milan criteria
    Toshiya Kamiyama
    Department of General Surgery, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    J Surg Oncol 101:54-60. 2010
    ..The aim of this study was to analyze the impact of anatomical resection for hepatocellular carcinoma (HCC) that meets the Milan criteria...
  47. ncbi request reprint Efficacy of preoperative radiotherapy to portal vein tumor thrombus in the main trunk or first branch in patients with hepatocellular carcinoma
    Toshiya Kamiyama
    The Department of General Surgery, Graduate School of Medicine, Hokkaido University, North 5, West 7, Kita ku, Sapporo 060 8638, Japan
    Int J Clin Oncol 12:363-8. 2007
    ..The prognosis of hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) in the main trunk or the first branch is very poor...
  48. ncbi request reprint Cytoplasmic expression of CD133 is an important risk factor for overall survival in hepatocellular carcinoma
    Ayami Sasaki
    Department of General Surgery, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Hokkaido, Japan
    Oncol Rep 24:537-46. 2010
    ..0681). Cytoplasmic expression of CD133 was a significant risk factor for the overall survival of HCC patients. Patients with stage III and IVA HCC showing positive cytoplasmic expression of CD133 are more likely to have a worse prognosis...
  49. doi request reprint Hyperplastic polyp of the gallbladder associated with pancreaticobiliary maljunction in a 9-year-old girl
    Tadao Okada
    Department of Pediatric Surgery, Hokkaido University Graduate School of Medicine, Kita ku, Kita 15, Nishi 7, Sapporo, 060 8638, Japan
    Pediatr Surg Int 25:999-1002. 2009
    ..Furthermore, the possible cause of the onset of hyperplastic polyp of the gallbladder complicated by PBM was explored in this report...
  50. doi request reprint Noble gene transduction into pancreatic beta-cells by singularizing islet cells with low doses of recombinant adenoviral vector
    Shusaku Tsukiyama
    First Department of Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Artif Organs 32:188-94. 2008
    ....
  51. doi request reprint The influence of hepatitis B DNA level and antiviral therapy on recurrence after initial curative treatment in patients with hepatocellular carcinoma
    Makoto Chuma
    Department of Gastroenterology and Hematology, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo, 060 8638, Japan
    J Gastroenterol 44:991-9. 2009
    ..Prediction and prevention of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) recurrence is an important clinical issue. We investigated whether HBV DNA level and antiviral therapy are associated with HCC recurrence...
  52. doi request reprint Disorders of interstitial cells of Cajal in a neonate with segmental dilatation of the intestine
    Tadao Okada
    Department of Pediatric Surgery, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    J Pediatr Surg 45:e11-4. 2010
    ..Furthermore, the possible neuropathic cause of SDI complicated with disorders of ICC was explored in this report...
  53. ncbi request reprint Laparoscopic liver biopsy using cup-shaped punch biopsy forceps and argon beam coagulator in children
    Tadao Okada
    Department of Pediatric Surgery, Hokkaido University Graduate School of Medicine, Kita ku, Kita 15, Nishi 7, Sapporo, 060 8638, Japan
    Pediatr Surg Int 23:947-51. 2007
    ..Laparoscopic liver biopsy combining the use of laparoscopic CPBF and an ABC handpiece can be performed safely, is less invasive, and provides sufficient samples for examination both by microscopy and enzyme activity assays...
  54. ncbi request reprint Pulmonary resection for metastases from hepatocellular carcinoma: factors influencing prognosis
    Takahito Nakagawa
    Department of General Surgery, Hokkaido University, Graduate School of Medicine, Sapporo, Japan
    J Thorac Cardiovasc Surg 131:1248-54. 2006
    ..We analyzed a single-center experience with 25 patients undergoing pulmonary resection of metastases from hepatocellular carcinoma to examine the clinical factors and outcomes...
  55. doi request reprint Liver transplantation for hepatocellular carcinoma: the Japanese experience
    Hiroyuki Furukawa
    Department of Organ Transplantation and Regenerative Medicine, Hokkaido University School of Medicine, N 15 W 7, Kitaku, Sapporo, 060 8648, Japan
    J Hepatobiliary Pancreat Sci 17:533-8. 2010
    ..Inclusion of tumor markers in addition to parameters of tumor morphology might be the key to establish the best criteria for liver transplantation for HCC...
  56. ncbi request reprint Percutaneous transluminal angioplasty for hepatic artery stenosis after living donor liver transplantation
    Yoshihisa Kodama
    Department of Radiology, Hokkaido University Graduate School of Medicine, Kitaku, Sapporo, Japan
    Liver Transpl 12:465-9. 2006
    ..7%, involving 2 of 30 procedures in total. In conclusion, PTA is effective for treatment of hepatic artery stenosis after living donor liver transplantation without an increase in the complication rate...
  57. ncbi request reprint The impact of bilateral breast cancer on the prognosis of breast cancer: a comparative study with unilateral breast cancer
    Hiromasa Takahashi
    Department of Pediatric Surgery, Hokkaido University Postgraduate School of Medicine, Kita 15 Nishi 7 Kita ku 060 8638 Sapporo, Japan
    Breast Cancer 12:196-202. 2005
    ..We assessed the impact of synchronous and metachronous bilateral breast cancer on the prognosis compared with unilateral breast cancer...
  58. ncbi request reprint Focal nodular hyperplasia of the liver: usefulness of superparamagnetic iron oxide-enhanced magnetic resonance imaging
    Tadao Okada
    Department of Pediatric Surgery, 1st Surgery, Pediatrics, Pathology, Hokkaido University School of Medicine, Sapporo, 060 8638, Japan
    J Pediatr Surg 40:E21-5. 2005
    ..This report describes the use of superparamagnetic iron oxide-enhanced magnetic resonance imaging to diagnose fibronodular hyperplasia of the liver in a 12-year-old girl...
  59. ncbi request reprint A new immunosuppressant, FTY720, in canine kidney transplantation: effect of single-drug, induction and combination treatments
    Tomomi Suzuki
    The First Department of Surgery, Hokkaido University School of Medicine, N 15, W 7, Kita ku, 060 8638 Sapporo, Japan
    Transpl Int 17:574-84. 2004
    ..FTY720 holds promise as a candidate in a new category of drugs that can be combined with conventional agents for induction and maintenance immunosuppression in clinical organ transplantation...
  60. ncbi request reprint Gene therapy-mediated CD40L and CD28 co-stimulatory signaling blockade plus transient anti-xenograft antibody suppression induces long-term acceptance of cardiac xenografts
    Nan Hua
    First Department of Surgery, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    Transplantation 78:1463-70. 2004
    ..In this study, the authors examined whether co-stimulation blockade with a brief course treatment of FK779, a novel leflunomide derivative, would be an ideal strategy for controlling xenograft rejection...
  61. ncbi request reprint Peripheral anatomic evaluation using 3D CT hepatic venography in donors: significance of peripheral venous visualization in living-donor liver transplantation
    Yuya Onodera
    Department of Radiology, Hokkaido University Graduate School of Medicine, North 15 West 7, Kita ku, Sapporo 060 8638, Japan
    AJR Am J Roentgenol 183:1065-70. 2004
    ..The purpose of this study was to determine clinical roles for 3D CT hepatic venography in the evaluation of peripheral hepatic venous anatomy during living-donor liver transplantation...
  62. ncbi request reprint A randomized controlled study of immunochemotherapy with OK-432 after curative surgery for gastric cancer
    Yuji Sato
    First Department of Surgery, School of Medicine, Hokkaido University, Sapporo, Japan
    J Immunother 27:394-7. 2004
    ..The 5-year survival rates for groups A and B were 62.9% and 63.8%, respectively, showing no significant difference (P = 0.7996)...
  63. ncbi request reprint A novel leflunomide derivative, FK778, for immunosuppression after kidney transplantation in dogs
    Maeng Bong Jin
    Department of Organ Transplantation and Regenerative Medicine, and Laboratory of Molecular and Cellular Pathology, Hokkaido University School of Medicine, Sapporo, Japan
    Surgery 132:72-9. 2002
    ..FK778, one synthetic malononitrilamide derived from A77 1726, is synthesized to overcome this problem while maintaining similar therapeutic efficacy...
  64. ncbi request reprint Combination treatment with FTY720 and CTLA4IgG preserves the respiratory epithelium and prevents obliterative disease in a murine airway model
    Katsuhito Konishi
    Division of Molecular Immunology, Institute for Genetic Medicine and First Department of Surgery, Hokkaido University, Sapporo, Japan
    J Heart Lung Transplant 21:692-700. 2002
    ..We evaluated whether treatment with either FTY720 or CTLA4IgG, or with combination FTY720 and CTLA4IgG could preserve the respiratory epithelium and inhibit the development of obliterative airway disease...
  65. ncbi request reprint A novel method for faster formation of rat liver cell spheroids
    Hisashi Okubo
    First Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan
    Artif Organs 26:497-505. 2002
    ..Using the new hepatocyte preparation method followed by a spinning culture, we were able to produce hepatocyte spheroids in as few as 6 h...
  66. ncbi request reprint Long-term acceptance of rat cardiac allografts on the basis of adenovirus mediated CD40Ig plus CTLA4Ig gene therapies
    Kenichiro Yamashita
    First Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan
    Transplantation 76:1089-96. 2003
    ..In this study, we asked whether these gene-therapy-based costimulation blockade would induce tolerance in cardiac transplantation...
  67. ncbi request reprint Macrophage migration inhibitory factor (MIF): Its potential role in tumor growth and tumor-associated angiogenesis
    Jun Nishihira
    Department of Molecular Biochemistry, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Ann N Y Acad Sci 995:171-82. 2003
    ..To further assess the role of MIF in tumorigenesis, we established MIF transgenic mice, which demonstrated that tumor growth and the associated angiogenesis were significantly enhanced in comparison with control mice...
  68. ncbi request reprint Alveolar echinococcosis: MR findings in the liver
    Yoshihisa Kodama
    Department of Radiology and First Department of Surgery, Hokkaido University School of Medicine, N15, W7, Kitaku, Sapporo, 060 8638, Japan
    Radiology 228:172-7. 2003
    ..To clarify the magnetic resonance (MR) imaging findings of alveolar echinococcosis in the liver...
  69. ncbi request reprint Postoperative portal and splenic vein thrombosis in children: identification of risk factors
    Tadao Okada
    Department of Pediatric Surgery, Hokkaido University Graduate School of Medicine, Kita ku, Kita 15, Nishi 7, Sapporo, 060 8638, Japan
    Pediatr Surg Int 21:918-21. 2005
    ..We conclude that clinicians should consider that PSVT might occur after splenectomy for a huge splenomegaly or after a total colectomy for ulcerative colitis...
  70. ncbi request reprint Hepatic venous reconstruction of anterior sector using three-dimensional helical computed tomography in living donor liver transplantation
    Masahiko Taniguchi
    Department of General Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Transplantation 81:797-9. 2006
    ..In these cases, when the area drained by the MHV tributary was excluded, GV/SV ratio were 26.1% and 35.7%, respectively. Based on this data, we reconstructed a large MHV tributary in both cases...
  71. ncbi request reprint Multiple mesenteric teratomas: usefulness of spiral computed tomography with 3-dimensional reconstruction
    Tadao Okada
    Department of Pediatric Surgery, Hokkaido University Graduate School of Medicine, and Hokkaido University Hospital, Sapporo 060 8638, Japan
    J Pediatr Surg 41:868-71. 2006
    ..This report describes the use of spiral computed tomography with 3-dimensional reconstruction for visualization of the extent of multiple mesenteric teratomas...
  72. ncbi request reprint Preoperative evaluation of hepatic vasculature by three-dimensional computed tomography in patients undergoing hepatectomy
    Toshiya Kamiyama
    Department of General Surgery, Graduate School of Medicine, Hokkaido University, North 15, West 7, Kita ku Sapporo, 060 8638, Japan
    World J Surg 30:400-9. 2006
    ....
  73. ncbi request reprint Effects of synthetic antifreeze glycoprotein analogue on islet cell survival and function during cryopreservation
    Shuichiro Matsumoto
    First Department of Surgery, Hokkaido University School of Medicine, N15 W7, Kita ku, Sapporo 060 8638, Japan
    Cryobiology 52:90-8. 2006
    ..In conclusion, the attenuation of ice crystallization by syAFGP improves islet survival and function following cryopreservation and thawing...
  74. ncbi request reprint Influence of continuous venovenous haemodiafiltration on the pharmacokinetics of tacrolimus in liver transplant recipients with small-for-size grafts
    S Kishino
    Department of Pharmacy, Hokkaido University Hospital, School of Medicine, Hokkaido University, Sapporo, Japan
    Clin Transplant 17:412-6. 2003
    ..9, 63.6 and 28.8 h. CVVHD did not cause a decrease in the blood tacrolimus concentration. Adjustment to the dose or dosing interval is not required for patients treated with tacrolimus during CVVHD...
  75. ncbi request reprint Management and algorithm for focal nodular hyperplasia of the liver in children
    T Okada
    Department of Pediatric Surgery, First Surgery, Radiology, Hokkaido University Graduate School of Medicine, and Hokkaido University Hospital, Pathology, Sapporo, Japan
    Eur J Pediatr Surg 16:235-40. 2006
    ..The aim of this study was to determine an appropriate management plan for childhood and adolescent FNH, in particular to establish an algorithm for preoperative diagnosis and treatment...
  76. ncbi request reprint Evidence of dual function of macrophage migration inhibitory factor relevant to tumor progression and regression
    Tsuyoshi Fukushima
    Department of Surgery, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Int J Mol Med 16:119-26. 2005
    ..Taken together, these results suggest that MIF has the potential to promote tumor growth and angiogenesis in the early phase and, by contrast, this protein could activate CD8+ cytotoxic T cells and NK cells, leading to tumor regression...
  77. ncbi request reprint Control of allograft rejection by applying a novel nuclear factor-kappaB inhibitor, dehydroxymethylepoxyquinomicin
    Shinya Ueki
    First Department of Surgery, Hokkaido University, Sapporo, Japan
    Transplantation 82:1720-7. 2006
    ..We examined the immunosuppressive effect of a newly developed NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ) in allotransplantation...
  78. doi request reprint Donor pretreatment with DHMEQ improves islet transplantation
    Tohru Takahashi
    Department of General Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan
    J Surg Res 163:e23-34. 2010
    ..We attempted to prevent islet apoptosis during isolation by a novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ)...
  79. ncbi request reprint Expression of ABC transporters in human hepatocyte carcinoma cells with cross-resistance to epirubicin and mitoxantrone
    Naoya Kamiyama
    Department of Clinical Pharmaceutics and Therapeutics, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12 jo, Nishi 6 chome, Kita ku, Sapporo 060 0812, Japan
    Anticancer Res 26:885-8. 2006
    ..In order to understand the cross-resistance between epirubicin (EPI) and mitoxantrone (MIT), EPI- and MIT-resistant cells were established and their cross-resistance was evaluated...
  80. ncbi request reprint Thrombopoietin in postoperative thrombocytopenia following living donor hepatectomy
    Yoshihide Nagasako
    First Department of Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Liver Transpl 12:435-9. 2006
    ..Also, with reduced consumption of platelets related to recovery from surgery, thrombocytopenia should resolve. As a consequence, TPO level would be expected to fall...
  81. ncbi request reprint BlotGlycoABCTM, an integrated glycoblotting technique for rapid and large scale clinical glycomics
    Yoshiaki Miura
    Graduate School of Life Science and Frontier Research Center for Post Genomic Science and Technology, Hokkaido University, Sapporo 001 0021, Japan
    Mol Cell Proteomics 7:370-7. 2008
    ..The method also permitted total cellular glycomics analysis of human prostate cancer cells and normal human prostate epithelial cells. These results demonstrate the potentials of glycan enrichment/processing for biomarker discovery...
  82. ncbi request reprint A novel fully human anti-CD40 monoclonal antibody, 4D11, for kidney transplantation in cynomolgus monkeys
    Atsushi Imai
    First Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan
    Transplantation 84:1020-8. 2007
    ..However, thromboembolic complications have prevented clinical application. Thus, blockade of the counter molecule by a novel fully human anti-CD40 mAb, 4D11, is an attractive alternative...
  83. ncbi request reprint Cost-utility of living donor liver transplantation in a single Japanese center
    Kozo Ishida
    Department of Global Health and Epidemiology, Division of Preventive Medicine Graduate School of Medicine, Hokkaido University, Hokkaido, Japan
    Hepatogastroenterology 53:588-91. 2006
    ..We conducted a cost-utility analysis to evaluate whether living donor liver transplantation is cost-effective...
  84. ncbi request reprint Role of cyclic nucleotides in ischemia and reperfusion injury of canine livers
    Hiroto Ishikawa
    First Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan
    Transplantation 73:1041-8. 2002
    ....
  85. doi request reprint Dehydroxymethylepoxyquinomicin (DHMEQ), a novel NF-kappaB inhibitor, inhibits allergic inflammation and airway remodelling in murine models of asthma
    K Shimizu
    First Department of Medicine, Hokkaido University School of Medicine, Kita ku, Sapporo, Japan
    Clin Exp Allergy 42:1273-81. 2012
    ..Because nuclear factor κB is a transcription factor that plays a critical role in the pathophysiology of asthma, DHMEQ may be of therapeutic benefit in asthma...
  86. doi request reprint Irreducible indirect inguinal hernia containing uterus, ovaries, and Fallopian tubes
    T Okada
    Department of Pediatric Surgery, Hokkaido University Hospital, Kita ku, Kita 14, Nishi 5, Sapporo, 060 8648, Japan
    Hernia 16:471-3. 2012
    ..Furthermore, the possible cause of indirect inguinal hernia containing the uterus, ovaries, and Fallopian tubes was explored...
  87. ncbi request reprint Effective esophageal balloon dilation for esophageal stenosis in recessive dystrophic epidermolysis bullosa
    T Okada
    Department of Pediatric Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Eur J Pediatr Surg 16:115-9. 2006
    ..The literature on such injuries is reviewed here, and the problems associated with the treatment of children with esophageal stenosis associated with RDEB are discussed...
  88. ncbi request reprint Long-term acceptance of allografts by in vivo gene transfer of regulatable adenovirus vector containing CTLA4IgG and loxP
    M Takehara
    Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan
    Hum Gene Ther 12:415-26. 2001
    ..More importantly, we also demonstrated that the long-term acceptance of allografts was achieved after the termination of CTLA4IgG expression, while the immune response against adenovirus was restored...
  89. doi request reprint Effect of intrasplenic transplantation of immortalized human hepatocytes in the treatment of acetaminophen-induced acute liver failure SCID mice
    Y Tsuruga
    Department of General Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Transplant Proc 40:617-9. 2008
    ..In this report, we transplanted minimally differentiated HHE6E7T-1 cells into the spleens of acute liver failure severe combined immunodeficiency (SCID) mice to examine the potential of the cells to redifferentiate in vivo...
  90. ncbi request reprint Bleeding disorder as the first symptom of biliary atresia
    T Okada
    Department of Pediatric Surgery, Pathology and First Surgery, Hokkaido University School of Medicine, Sapporo, Japan
    Eur J Pediatr Surg 15:295-9. 2005
    ..Subsequently, BA was suspected to be the cause of these bleeding disorders based on imaging findings. BA should therefore be considered in all infants with sudden onset of a tendency to bleed...
  91. pmc Development of a yeast stop codon assay readily and generally applicable to human genes
    A Kataoka
    First Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan
    Am J Pathol 159:1239-45. 2001
    ....
  92. ncbi request reprint Surgical stress and tumor behavior: impact of ischemia-reperfusion and hepatic resection on tumor progression
    Michitaka Ozaki
    Liver Transpl 13:1623-6. 2007
  93. ncbi request reprint Critical involvement of the phosphatidylinositol 3-kinase/Akt pathway in anchorage-independent growth and hematogeneous intrahepatic metastasis of liver cancer
    Kazuaki Nakanishi
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Res 62:2971-5. 2002
    ..These findings indicated that anchorage-independent growth regulated by phosphatidylinositol 3-kinase/Akt pathway plays a critical role in metastasis, and that this could be a potential therapeutic target to combat metastasis...
  94. ncbi request reprint Local administration of IL-12-transfected dendritic cells induces antitumor immune responses to colon adenocarcinoma in the liver in mice
    Yuji Satoh
    Biologic Therapeutics Program, University of Pittsburgh Cancer Institute, 5725 CHP MT, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    J Exp Ther Oncol 2:337-49. 2002
    ..Simultaneous local gene therapy with IL-12 will further improve clinical efficacy without placing the patient at risk for systemic toxicity...
  95. ncbi request reprint [Modified pharmacokinetic modulation chemotherapy (PMC) with medication of UFT and intraarterial infusion of 5-FU for advanced unresectable HCC]
    Toshiya Kamiyama
    Hokkaido University Graduate School
    Gan To Kagaku Ryoho 29:2527-31. 2002
    ..Advanced unresectable hepatocellular carcinoma (HCC) was treated with modified pharmacokinetic modulation chemotherapy (PMC)...
  96. ncbi request reprint Acceptance of islet allografts in the liver of mice by blockade of an inducible costimulator
    Yoshiichiroh Nakamura
    Department of Surgery I, Fukuoka University School of Medicine, Fukuoka, Japan
    Transplantation 75:1115-8. 2003
    ..This study determined whether ICOS plays an essential role in rejection of intrahepatic islet allografts in streptozotocin-induced diabetic mice...
  97. ncbi request reprint Chemosensitivity prediction in esophageal squamous cell carcinoma: novel marker genes and efficacy-prediction formulae using their expression data
    Tatsushi Shimokuni
    Department of Translational Cancer Research, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734 8553, Japan
    Int J Oncol 28:1153-62. 2006
    ..Our selected genes are likely to be effective drug-sensitivity markers and formulae using the 9 novel genes would provide advantages in prediction...
  98. ncbi request reprint p73 and MDM2 confer the resistance of epidermoid carcinoma to cisplatin by blocking p53
    Syunji Hayashi
    Division of Biochemistry, Chiba Cancer Center Research Institute, Chuoh ku, Japan
    Biochem Biophys Res Commun 347:60-6. 2006
    ..Collectively, our results suggest that a loss of the cisplatin sensitivity is at least in part due to a lack of cisplatin-induced p53 phosphorylation, and p73 might cooperate with MDM2 to be involved in this process...
  99. ncbi request reprint [Efficacy and toxicity of combination treatment with epirubicin (EPI) plus docetaxel (DOC) in advanced breast cancer]
    Masato Takahashi
    First Dept of Surgery, Hokkaido University Hospital
    Gan To Kagaku Ryoho 33:1583-7. 2006
    ..The most common grade 3/4 adverse events were neutropenia (26.7%) and general fatigue (6.7%). The simultaneous combination treatment of EPI and DOC is effective for primary chemotherapy and can be performed safely even for outpatients...
  100. ncbi request reprint Protein expression associated with early intrahepatic recurrence of hepatocellular carcinoma after curative surgery
    Hideki Yokoo
    Proteome Bioinformatics Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo ku Tokyo 104 0045, Japan
    Cancer Sci 98:665-73. 2007
    ..The identified proteins may be candidates for prognostic markers and contribute to the improvement of existing therapeutic strategies...
  101. ncbi request reprint [In vitro chemosensitivity test for hepatocellular carcinoma using collagen-gel droplet embedded cultures]
    Takahito Nakagawa
    Dept of General Surgery, Hokkaido University, Graduate School of Medicine
    Gan To Kagaku Ryoho 31:2145-9. 2004
    ..Growth rates of HCC for 7 days of culture were significantly lower than those of breast cancers (1.04 vs 3.61). The culture methods for HCC in CD-DST should be improved to estimate accurate results...