K Takada

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. ncbi request reprint The role of EBERs in oncogenesis
    K Takada
    Department of Tumour Virology, Institute for Genetic Medicine, Hokkaido University, Sapporo 060 0815, Japan
    Semin Cancer Biol 11:461-7. 2001
  2. pmc Epstein-Barr virus and gastric carcinoma
    K Takada
    Department of Tumor Virology, Hokkaido University, Sapporo, Japan
    Mol Pathol 53:255-61. 2000
  3. pmc Replacement of the Epstein-Barr virus plasmid with the EBER plasmid in Burkitt's lymphoma cells
    S Maruo
    Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, N15 W7, Kita-ku, Sapporo 060-0815, Japan
    J Virol 75:9977-82. 2001
  4. ncbi request reprint Role of Epstein-Barr virus-encoded latent membrane protein 2A on virus-induced immortalization and virus activation
    K Konishi
    Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, N15 W7, Kita-ku, 060-8638 Sapporo, Japan
    J Gen Virol 82:1451-6. 2001
  5. doi request reprint Epstein-Barr virus-encoded small RNA induces IL-10 through RIG-I-mediated IRF-3 signaling
    M Samanta
    Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Oncogene 27:4150-60. 2008
  6. ncbi request reprint Roles of Epstein-Barr virus glycoproteins gp350 and gp25 in the infection of human epithelial cells
    S Maruo
    Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, Sapporo 060-8638, Japan
    J Gen Virol 82:2373-83. 2001
  7. ncbi request reprint Role of Epstein-Barr virus in Burkitt's lymphoma
    K Takada
    Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, N15 W7, Kita-ku, Sapporo 060-8638, Japan
    Curr Top Microbiol Immunol 258:141-51. 2001
  8. pmc Role of bcl-2 in Epstein-Barr virus-induced malignant conversion of Burkitt's lymphoma cell line Akata
    J Komano
    Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, Kita-ku, Sapporo 060-8638, Japan
    J Virol 75:1561-4. 2001
  9. ncbi request reprint Cloning of canine 21-hydroxylase gene and its polymorphic analysis as a candidate gene for congenital adrenal hyperplasia-like syndrome in Pomeranians
    K Takada
    Laboratory of Pathobiology, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Res Vet Sci 73:159-63. 2002
  10. ncbi request reprint Application of pressure-controlled colon delivery capsule to oral administration of glycyrrhizin in dogs
    N Shibata
    Department of Pharmacokinetics, Kyoto Pharmaceutical University, Japan
    J Pharm Pharmacol 53:441-7. 2001

Collaborators

  • L Yang
  • A Hashimoto
  • M Saito
  • H Kato
  • Yoshihisa Fujita
  • N Shibata
  • S Maruo
  • M Samanta
  • Y Yoshikawa
  • N Venkatesan
  • S Eiamtrakarn
  • M Murakami
  • T Ohno
  • Y I Jeong
  • J Komano
  • K Konishi
  • Z Hu
  • D Iwakiri
  • Y Ohashi
  • Y Ito
  • J Yoshimitsu
  • N Sugioka
  • Y Itoh
  • J Kishimoto
  • K Koga
  • S Nagata
  • T Shimokawa
  • A Nanbo
  • K Miyamoto
  • H Kanayama
  • H Segawa
  • S Tatsumi
  • K Sone
  • H Yamamoto
  • K Katai
  • K Morita
  • Y Taketani

Detail Information

Publications15

  1. ncbi request reprint The role of EBERs in oncogenesis
    K Takada
    Department of Tumour Virology, Institute for Genetic Medicine, Hokkaido University, Sapporo 060 0815, Japan
    Semin Cancer Biol 11:461-7. 2001
    ..Furthermore, EBERs induce transcription of interleukin-10, which acts as an autocrine growth factor of BL. These studies open the way toward the new concept that RNA molecules can act in oncogenesis...
  2. pmc Epstein-Barr virus and gastric carcinoma
    K Takada
    Department of Tumor Virology, Hokkaido University, Sapporo, Japan
    Mol Pathol 53:255-61. 2000
    ..These results suggest that EBV contributes to the maintenance of the malignant phenotype of EBV positive gastric carcinoma...
  3. pmc Replacement of the Epstein-Barr virus plasmid with the EBER plasmid in Burkitt's lymphoma cells
    S Maruo
    Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, N15 W7, Kita-ku, Sapporo 060-0815, Japan
    J Virol 75:9977-82. 2001
    ..The results suggest that EBER could replace the role of EBV, but other EBV products also play a role in the growth of BL...
  4. ncbi request reprint Role of Epstein-Barr virus-encoded latent membrane protein 2A on virus-induced immortalization and virus activation
    K Konishi
    Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, N15 W7, Kita-ku, 060-8638 Sapporo, Japan
    J Gen Virol 82:1451-6. 2001
    ..The results raise a question as to the role of LMP2A in inhibition of disruption of virus latency in vivo, where LMP2A expression has been expected to be low as in Akata cells...
  5. doi request reprint Epstein-Barr virus-encoded small RNA induces IL-10 through RIG-I-mediated IRF-3 signaling
    M Samanta
    Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Oncogene 27:4150-60. 2008
    ..These findings suggest a new mechanism of dsRNA signaling pathway that triggers the expression of IL-10, which acts as an autocrine growth factor in BL cells...
  6. ncbi request reprint Roles of Epstein-Barr virus glycoproteins gp350 and gp25 in the infection of human epithelial cells
    S Maruo
    Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, Sapporo 060-8638, Japan
    J Gen Virol 82:2373-83. 2001
    ..These results indicate the existence of two distinct pathways in EBV infection of epithelial cells, a gp350-dependent pathway and a gp350-independent pathway, and that gp25 can play a role in the infection of some epithelial cells...
  7. ncbi request reprint Role of Epstein-Barr virus in Burkitt's lymphoma
    K Takada
    Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, N15 W7, Kita-ku, Sapporo 060-8638, Japan
    Curr Top Microbiol Immunol 258:141-51. 2001
    ..1991; Bissonnette et al. 1992; Fanidi et al. 1992; Karsan et al. 1993; Mohammad et al. 1993; Oltvai et al. 1993; Marin et al. 1995). In this way bcl-2 might cooperate with c-myc in the development of BL (Fig. 5)...
  8. pmc Role of bcl-2 in Epstein-Barr virus-induced malignant conversion of Burkitt's lymphoma cell line Akata
    J Komano
    Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, Kita-ku, Sapporo 060-8638, Japan
    J Virol 75:1561-4. 2001
    ..These data indicate that EBV targets not only bcl-2, but also an unknown pathway(s) to enhance the oncogenic potential of Akata cells...
  9. ncbi request reprint Cloning of canine 21-hydroxylase gene and its polymorphic analysis as a candidate gene for congenital adrenal hyperplasia-like syndrome in Pomeranians
    K Takada
    Laboratory of Pathobiology, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Res Vet Sci 73:159-63. 2002
    ..Our results indicate that the adrenal dysfunction in Pomeranians is not due to mutations of the 21-OH gene. This contrasts with the human form of CAH where 21-OH gene mutations are the major cause of the disease...
  10. ncbi request reprint Application of pressure-controlled colon delivery capsule to oral administration of glycyrrhizin in dogs
    N Shibata
    Department of Pharmacokinetics, Kyoto Pharmaceutical University, Japan
    J Pharm Pharmacol 53:441-7. 2001
    ..Labrasol, which is a component of self-emulsifying drug delivery systems (SEDDS), has been shown to strongly improve the bioavailability of glycyrrhizin from the colon...
  11. ncbi request reprint Evaluation of an intestinal pressure-controlled colon delivery capsules prepared by a dipping method
    Y I Jeong
    Department of Pharmacokinetics, Kyoto Pharmaceutical University, Yamashina-ku, 607-8414, Kyoto, Japan
    J Control Release 71:175-82. 2001
    ..5+/-0.7 h for thicker ones. Since the colon arrival time in beagle dogs was 3.5+/-0.3 h as determined by a sulfasalazine test, thinner HPMCAS PCDCs and thicker HPMCP PCDCs were thought to deliver FL to the colon...
  12. ncbi request reprint A novel heparin-binding protein, HBp15, is identified as mammalian ribosomal protein L22
    Y Fujita
    Department of Oral and Maxillofacial Surgery 1, Hiroshima University School of Dentistry, Japan
    Biochem Biophys Res Commun 199:706-13. 1994
    ..Using specific antibodies against HBp15, HBp15 was identified as mammalian ribosomal protein L22, for which no sequence information is available...
  13. ncbi request reprint Gastrointestinal mucoadhesive patch system (GI-MAPS) for oral administration of G-CSF, a model protein
    S Eiamtrakarn
    Department of Pharmaceutics and Pharmacokinetics, Kyoto Pharmaceutical University, Japan
    Biomaterials 23:145-52. 2002
    ..5% and 6.0% for Eudragit L100, HP-55 and Eudragit S100 systems. By decreasing the amount of HCO-60 and citric acid, the PA of G-CSF decreased. These results suggest the usefulness of GI-MAPS for the oral administration of proteins...
  14. ncbi request reprint Pharmacokinetic and pharmacodynamic studies following oral administration of erythropoietin mucoadhesive tablets to beagle dogs
    N Venkatesan
    Department of Pharmacokinetics, Kyoto Pharmaceutical University, Misasagi, Kyoto 607 8414, Japan
    Int J Pharm 310:46-52. 2006
    ..v. route at a dose of 300 IU/kg for 3 consecutive days and the percent circulating reticulocytes were counted. Mucoadhesive tablets showed promising results as an oral drug delivery system for protein therapeutics...
  15. pmc Mutations of the basic amino acid transporter gene associated with cystinuria
    K Miyamoto
    Department of Clinical Nutrition, School of Medicine, Tokushima University, Japan
    Biochem J 310:951-5. 1995
    ..In addition, co-injection experiments suggest that rBAT may function as a transport activator or regulatory subunit by homo- or hetero-multimer complex formation...