Affiliation: Hokkaido University
- The role of EBERs in oncogenesisK Takada
Department of Tumour Virology, Institute for Genetic Medicine, Hokkaido University, Sapporo 060 0815, Japan
Semin Cancer Biol 11:461-7. 2001..Furthermore, EBERs induce transcription of interleukin-10, which acts as an autocrine growth factor of BL. These studies open the way toward the new concept that RNA molecules can act in oncogenesis...
- Epstein-Barr virus and gastric carcinomaK Takada
Department of Tumor Virology, Hokkaido University, Sapporo, Japan
Mol Pathol 53:255-61. 2000..These results suggest that EBV contributes to the maintenance of the malignant phenotype of EBV positive gastric carcinoma...
- Replacement of the Epstein-Barr virus plasmid with the EBER plasmid in Burkitt's lymphoma cellsS Maruo
Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, N15 W7, Kita-ku, Sapporo 060-0815, Japan
J Virol 75:9977-82. 2001..The results suggest that EBER could replace the role of EBV, but other EBV products also play a role in the growth of BL...
- Role of Epstein-Barr virus-encoded latent membrane protein 2A on virus-induced immortalization and virus activationK Konishi
Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, N15 W7, Kita-ku, 060-8638 Sapporo, Japan
J Gen Virol 82:1451-6. 2001..The results raise a question as to the role of LMP2A in inhibition of disruption of virus latency in vivo, where LMP2A expression has been expected to be low as in Akata cells...
- Epstein-Barr virus-encoded small RNA induces IL-10 through RIG-I-mediated IRF-3 signalingM Samanta
Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
Oncogene 27:4150-60. 2008..These findings suggest a new mechanism of dsRNA signaling pathway that triggers the expression of IL-10, which acts as an autocrine growth factor in BL cells...
- Roles of Epstein-Barr virus glycoproteins gp350 and gp25 in the infection of human epithelial cellsS Maruo
Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, Sapporo 060-8638, Japan
J Gen Virol 82:2373-83. 2001..These results indicate the existence of two distinct pathways in EBV infection of epithelial cells, a gp350-dependent pathway and a gp350-independent pathway, and that gp25 can play a role in the infection of some epithelial cells...
- Role of Epstein-Barr virus in Burkitt's lymphomaK Takada
Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, N15 W7, Kita-ku, Sapporo 060-8638, Japan
Curr Top Microbiol Immunol 258:141-51. 2001..1991; Bissonnette et al. 1992; Fanidi et al. 1992; Karsan et al. 1993; Mohammad et al. 1993; Oltvai et al. 1993; Marin et al. 1995). In this way bcl-2 might cooperate with c-myc in the development of BL (Fig. 5)...
- Role of bcl-2 in Epstein-Barr virus-induced malignant conversion of Burkitt's lymphoma cell line AkataJ Komano
Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, Kita-ku, Sapporo 060-8638, Japan
J Virol 75:1561-4. 2001..These data indicate that EBV targets not only bcl-2, but also an unknown pathway(s) to enhance the oncogenic potential of Akata cells...
- Cloning of canine 21-hydroxylase gene and its polymorphic analysis as a candidate gene for congenital adrenal hyperplasia-like syndrome in PomeraniansK Takada
Laboratory of Pathobiology, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
Res Vet Sci 73:159-63. 2002..Our results indicate that the adrenal dysfunction in Pomeranians is not due to mutations of the 21-OH gene. This contrasts with the human form of CAH where 21-OH gene mutations are the major cause of the disease...
- Application of pressure-controlled colon delivery capsule to oral administration of glycyrrhizin in dogsN Shibata
Department of Pharmacokinetics, Kyoto Pharmaceutical University, Japan
J Pharm Pharmacol 53:441-7. 2001..Labrasol, which is a component of self-emulsifying drug delivery systems (SEDDS), has been shown to strongly improve the bioavailability of glycyrrhizin from the colon...
- Evaluation of an intestinal pressure-controlled colon delivery capsules prepared by a dipping methodY I Jeong
Department of Pharmacokinetics, Kyoto Pharmaceutical University, Yamashina-ku, 607-8414, Kyoto, Japan
J Control Release 71:175-82. 2001..5+/-0.7 h for thicker ones. Since the colon arrival time in beagle dogs was 3.5+/-0.3 h as determined by a sulfasalazine test, thinner HPMCAS PCDCs and thicker HPMCP PCDCs were thought to deliver FL to the colon...
- A novel heparin-binding protein, HBp15, is identified as mammalian ribosomal protein L22Y Fujita
Department of Oral and Maxillofacial Surgery 1, Hiroshima University School of Dentistry, Japan
Biochem Biophys Res Commun 199:706-13. 1994..Using specific antibodies against HBp15, HBp15 was identified as mammalian ribosomal protein L22, for which no sequence information is available...
- Gastrointestinal mucoadhesive patch system (GI-MAPS) for oral administration of G-CSF, a model proteinS Eiamtrakarn
Department of Pharmaceutics and Pharmacokinetics, Kyoto Pharmaceutical University, Japan
Biomaterials 23:145-52. 2002..5% and 6.0% for Eudragit L100, HP-55 and Eudragit S100 systems. By decreasing the amount of HCO-60 and citric acid, the PA of G-CSF decreased. These results suggest the usefulness of GI-MAPS for the oral administration of proteins...
- Pharmacokinetic and pharmacodynamic studies following oral administration of erythropoietin mucoadhesive tablets to beagle dogsN Venkatesan
Department of Pharmacokinetics, Kyoto Pharmaceutical University, Misasagi, Kyoto 607 8414, Japan
Int J Pharm 310:46-52. 2006..v. route at a dose of 300 IU/kg for 3 consecutive days and the percent circulating reticulocytes were counted. Mucoadhesive tablets showed promising results as an oral drug delivery system for protein therapeutics...
- Mutations of the basic amino acid transporter gene associated with cystinuriaK Miyamoto
Department of Clinical Nutrition, School of Medicine, Tokushima University, Japan
Biochem J 310:951-5. 1995..In addition, co-injection experiments suggest that rBAT may function as a transport activator or regulatory subunit by homo- or hetero-multimer complex formation...