Toshiharu Suzuki

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. ncbi request reprint Suppression of the caspase cleavage of beta-amyloid precursor protein by its cytoplasmic phosphorylation
    Hidenori Taru
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita ku, Sapporo 060 0812, Japan
    FEBS Lett 567:248-52. 2004
  2. pmc The product of uncI gene in F1Fo-ATP synthase operon plays a chaperone-like role to assist c-ring assembly
    Toshiharu Suzuki
    ATP Synthesis Regulation Project, ICORP, Japan Science and Technology Corporation, Aomi 2 41, Tokyo 135 0064, Japan
    Proc Natl Acad Sci U S A 104:20776-81. 2007
  3. pmc X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain
    Yuhki Saito
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita12 Nishi6, Sapporo 060 0812, Japan
    J Biol Chem 283:35763-71. 2008
  4. pmc Mechanism of intramembrane cleavage of alcadeins by γ-secretase
    Yi Piao
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    PLoS ONE 8:e62431. 2013
  5. pmc Constitutive cleavage of the single-pass transmembrane protein alcadeinα prevents aberrant peripheral retention of Kinesin-1
    Chiaki Maruta
    Laboratory of Neuroscience, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    PLoS ONE 7:e43058. 2012
  6. pmc FE65 as a link between VLDLR and APP to regulate their trafficking and processing
    Sonya B Dumanis
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road NW, Washington, DC 20057 1464, USA
    Mol Neurodegener 7:9. 2012
  7. pmc Evidence against roles for phorbol binding protein Munc13-1, ADAM adaptor Eve-1, or vesicle trafficking phosphoproteins Munc18 or NSF as phospho-state-sensitive modulators of phorbol/PKC-activated Alzheimer APP ectodomain shedding
    Annat F Ikin
    Farber Institute for Neurosciences of Thomas Jefferson University, 900 Walnut Street, Philadelphia, 19107, PA, USA
    Mol Neurodegener 2:23. 2007
  8. pmc Regulation of amyloid beta-protein precursor by phosphorylation and protein interactions
    Toshiharu Suzuki
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita ku, Sapporo 060 0812, Japan
    J Biol Chem 283:29633-7. 2008
  9. pmc Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain
    Maho Kondo
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita12 Nishi6, Kita ku, Sapporo 060 0812, Japan
    Mol Neurodegener 5:35. 2010
  10. ncbi request reprint Trafficking of Alzheimer's disease-related membrane proteins and its participation in disease pathogenesis
    Toshiharu Suzuki
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita ku, Sapporo 060 0812
    J Biochem 139:949-55. 2006

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Suppression of the caspase cleavage of beta-amyloid precursor protein by its cytoplasmic phosphorylation
    Hidenori Taru
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita ku, Sapporo 060 0812, Japan
    FEBS Lett 567:248-52. 2004
    ..This suggests that APP phosphorylation suppresses the generation of caspase-cleaved fragments of APP in the brain and that perturbation of this phosphorylation may be involved in APP-mediated neurotoxicity...
  2. pmc The product of uncI gene in F1Fo-ATP synthase operon plays a chaperone-like role to assist c-ring assembly
    Toshiharu Suzuki
    ATP Synthesis Regulation Project, ICORP, Japan Science and Technology Corporation, Aomi 2 41, Tokyo 135 0064, Japan
    Proc Natl Acad Sci U S A 104:20776-81. 2007
    ..Na(+) induced dissociation of His-tagged UncI protein from c(11)-ring but not from c-monomers. These results show that UncI is a chaperone-like protein that assists c(11)-ring assembly from c-monomers in the membrane...
  3. pmc X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain
    Yuhki Saito
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita12 Nishi6, Sapporo 060 0812, Japan
    J Biol Chem 283:35763-71. 2008
    ..Present results lead to an idea that the dysfunction of X11L in the interaction with APP may recruit more APP into DRM and increase the generation of Abeta even if BACE activity did not increase in brain...
  4. pmc Mechanism of intramembrane cleavage of alcadeins by γ-secretase
    Yi Piao
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    PLoS ONE 8:e62431. 2013
    ..However, initial intracellular ε-cleavage sites of Alc CTF to generate Alc ICD and the molecular mechanism that final γ-site position is determined remains unclear in Alcs...
  5. pmc Constitutive cleavage of the single-pass transmembrane protein alcadeinα prevents aberrant peripheral retention of Kinesin-1
    Chiaki Maruta
    Laboratory of Neuroscience, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    PLoS ONE 7:e43058. 2012
    ..This role might exemplify the functional relevance of the constitutive cleavage of single-pass transmembrane proteins...
  6. pmc FE65 as a link between VLDLR and APP to regulate their trafficking and processing
    Sonya B Dumanis
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road NW, Washington, DC 20057 1464, USA
    Mol Neurodegener 7:9. 2012
    ..In the present study, we tested whether FE65 can interact with another ApoE receptor, VLDLR, thereby altering its trafficking and processing, and whether FE65 can serve as a linker between APP and VLDLR...
  7. pmc Evidence against roles for phorbol binding protein Munc13-1, ADAM adaptor Eve-1, or vesicle trafficking phosphoproteins Munc18 or NSF as phospho-state-sensitive modulators of phorbol/PKC-activated Alzheimer APP ectodomain shedding
    Annat F Ikin
    Farber Institute for Neurosciences of Thomas Jefferson University, 900 Walnut Street, Philadelphia, 19107, PA, USA
    Mol Neurodegener 2:23. 2007
    ..Here, we examined the effects on APP ectodomain shedding of four phorbol-sensitive proteins involved in regulation of vesicular membrane trafficking of APP: Munc13-1, Munc18, NSF, and Eve-1...
  8. pmc Regulation of amyloid beta-protein precursor by phosphorylation and protein interactions
    Toshiharu Suzuki
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita ku, Sapporo 060 0812, Japan
    J Biol Chem 283:29633-7. 2008
    ..Recent findings regarding the regulation of APP processing contribute to the development of novel drugs and/or therapies for Alzheimer disease...
  9. pmc Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain
    Maho Kondo
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita12 Nishi6, Kita ku, Sapporo 060 0812, Japan
    Mol Neurodegener 5:35. 2010
    ..Therefore, the data on X11-family protein function in transgenic human APP metabolism in vivo are inconsistent...
  10. ncbi request reprint Trafficking of Alzheimer's disease-related membrane proteins and its participation in disease pathogenesis
    Toshiharu Suzuki
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita ku, Sapporo 060 0812
    J Biochem 139:949-55. 2006
    ..Here we review recent progress of research on AD pathogenesis from the viewpoint of membrane trafficking...
  11. ncbi request reprint Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation
    Yoichi Araki
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita Ku Kita 12 Nishi 6, Sapporo 060 0812, Japan
    J Biol Chem 279:24343-54. 2004
    ..Any imbalance in the metabolism of Alcs and APP may influence the FE65-dependent gene transactivation, which together with increased secretion of amyloid beta-protein may contribute to neural disorders...
  12. pmc The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport
    Yoichi Araki
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    EMBO J 26:1475-86. 2007
    ..Inappropriate interactions of Alc- and APP-containing vesicles with kinesin-1 may promote aberrant APP metabolism in Alzheimer's disease...
  13. doi request reprint A small peptide sequence is sufficient for initiating kinesin-1 activation through part of TPR region of KLC1
    Takanori Kawano
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Traffic 13:834-48. 2012
    ..These observations suggest that structurally different TPR-interacting peptides may have different effects on kinesin-1. This mechanism may partly explain how kinesin-1 can organize the transport of a wide variety of cargo molecules...
  14. doi request reprint Suppression of APP-containing vesicle trafficking and production of beta-amyloid by AID/DHHC-12 protein
    Chie Mizumaru
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    J Neurochem 111:1213-24. 2009
    ....
  15. pmc Phosphorylation of the amino-terminal region of X11L regulates its interaction with APP
    Megumi Sakuma
    Hokkaido University, Kita ku, Sapporo, Japan
    J Neurochem 109:465-75. 2009
    ..Modification of this regulatory region may alter the conformation of the PI/PTB domain to modulate APP binding...
  16. doi request reprint Roles of the intramolecular regions of FE65 in its trans-accumulation and in p53 stabilization in the nuclear matrix of osmotically stressed cells
    Tomoko Kawai
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita ku, Sapporo, Japan
    FEBS Lett 584:765-9. 2010
    ..The carboxyl-terminal half of FE65, which contains the PI2 domain, failed to stabilize p53, suggesting that the amino-terminal half of the protein plays an important role in the stabilization of p53 in osmotically stressed cells...
  17. ncbi request reprint Facilitation of stress-induced phosphorylation of beta-amyloid precursor protein family members by X11-like/Mint2 protein
    Hidenori Taru
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita Ku Kita 12 Nishi 6, Sapporo 060 0812, Japan
    J Biol Chem 279:21628-36. 2004
    ....
  18. pmc Intracellular trafficking of the amyloid β-protein precursor (APP) regulated by novel function of X11-like
    Yuhki Saito
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Science, Hokkaido University, Sapporo, Japan
    PLoS ONE 6:e22108. 2011
    ..X11L suppresses amyloidogenic cleavage of mAPP by direct binding of X11L through its PTB domain, thereby generation of Aβ lowers. X11L expresses another function in the regulation of intracellular APP trafficking...
  19. ncbi request reprint Role of APP phosphorylation in FE65-dependent gene transactivation mediated by AICD
    Tadashi Nakaya
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita ku, Sapporo 060 0812, Japan
    Genes Cells 11:633-45. 2006
    ..Therefore, phosphorylation of APP but not AICD modulates FE65-dependent gene transactivation mediated by AICD through the regulation of FE65 intracellular localization...
  20. ncbi request reprint Role of 14-3-3gamma in FE65-dependent gene transactivation mediated by the amyloid beta-protein precursor cytoplasmic fragment
    Akio Sumioka
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita ku, Sapporo 060 0812, Japan
    J Biol Chem 280:42364-74. 2005
    ..Our findings suggest that multiple interactions of AICD with FE65 and 14-3-3gamma modulate FE65-dependent gene transactivation...
  21. ncbi request reprint Enhanced amyloidogenic metabolism of the amyloid beta-protein precursor in the X11L-deficient mouse brain
    Yoshitake Sano
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita ku, Sapporo 060 0812, Japan
    J Biol Chem 281:37853-60. 2006
    ..These observations clearly indicate that X11L suppresses the amyloidogenic but not amyloidolytic processing of APP in regions of the brain such as the hippocampus, which express significant levels of X11L...
  22. ncbi request reprint Metabolic stabilization of p53 by FE65 in the nuclear matrix of osmotically stressed cells
    Tadashi Nakaya
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    FEBS J 276:6364-74. 2009
    ....
  23. doi request reprint Regulation of FE65 nuclear translocation and function by amyloid beta-protein precursor in osmotically stressed cells
    Tadashi Nakaya
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita ku, Sapporo 060 0812, Japan
    J Biol Chem 283:19119-31. 2008
    ..These observations suggest that APP-regulated FE65 plays an important role in the early stress response of cells and that FE65 deregulated from APP induces apoptosis...
  24. ncbi request reprint Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism
    Yoichi Araki
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita Ku Kita 12 Nishi 6, Sapporo 060 0812, Japan
    J Biol Chem 278:49448-58. 2003
    ..Deficiencies in the X11L-mediated interaction between Alc and APP and/or CTFbeta enhanced the production of Abeta, which may be related to the development or progression of AD...
  25. pmc Membrane-microdomain localization of amyloid β-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue
    Takahide Matsushima
    From the Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    J Biol Chem 287:19715-24. 2012
    ..By this mechanism, nCTFs can be preferentially captured and cleaved by γ-secretase. Preservation of the phosphorylated state of APP-CTFs may be a potential treatment to lower the generation of Aβ in Alzheimer disease...
  26. pmc Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for γ-secretase dysfunction
    Saori Hata
    Department of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Ann Neurol 69:1026-31. 2011
    ..Although no PS1 mutations are present, altered Aβ42/40 ratios are also observed in sporadic Alzheimer's disease (SAD), and these altered ratios apparently reflect deposition of Aβ42 as amyloid...
  27. doi request reprint The X11L/X11beta/MINT2 and X11L2/X11gamma/MINT3 scaffold proteins shuttle between the nucleus and cytoplasm
    Akio Sumioka
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Exp Cell Res 314:1155-62. 2008
    ..Our observations suggest that X11L2 functions in the nucleus by a mechanism distinct from conventional transactivators...
  28. pmc Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction
    Saori Hata
    Department of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    J Biol Chem 284:36024-33. 2009
    ....
  29. ncbi request reprint Regulation of the physiological function and metabolism of AbetaPP by AbetaPP binding proteins
    Hidenori Taru
    Creative Research Institution Sousei, Hokkaido University, Kita ku, Sapporo, Japan
    J Alzheimers Dis 18:253-65. 2009
    ..This article reviews some of the recent findings regarding the regulation of physiological function and metabolism of AbetaPP by AbetaPP binding proteins...
  30. doi request reprint IgSF molecule MDGA1 is involved in radial migration and positioning of a subset of cortical upper-layer neurons
    Takao Ishikawa
    Laboratory of Neuroscience, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Dev Dyn 240:96-107. 2011
    ..These observations indicated that Mdga1 is involved in the migration and positioning of a subset of cortical neurons and suggested that the radial migration of upper-layer neurons might be differentially regulated...
  31. pmc Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Aβ generation in Alzheimer's disease
    Yuhki Saito
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita12 Nishi6, Kita ku, Sapporo, 060 0812, Japan
    Mol Neurodegener 7:50. 2012
    ..However, the molecular linkage between epileptic seizures and Aβ generation in AD remains unclear...
  32. pmc Expression of sorting nexin 18 (SNX18) is dynamically regulated in developing spinal motor neurons
    Shiori Nakazawa
    Laboratory of Neuroscience, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    J Histochem Cytochem 59:202-13. 2011
    ..These findings collectively suggest that SNX18 may play an active role in axonal elongation...
  33. pmc Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer's disease subjects
    Saori Hata
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Mol Neurodegener 7:16. 2012
    ..Aβ and p3-Alcα can be recovered from human cerebrospinal fluid (CSF). We have previously reported alternative processing of APP and Alcα in the CSF of some patients with sporadic mild cognitive impairment (MCI) and AD (SAD)...
  34. pmc Coordinated increase of γ-secretase reaction products in the plasma of some female Japanese sporadic Alzheimer's disease patients: quantitative analysis of p3-Alcα with a new ELISA system
    Tomoko Konno
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Mol Neurodegener 6:76. 2011
    ....
  35. ncbi request reprint [Novel mechanisms in signal transduction and cellular response through neural adaptor proteins]
    Akio Sumioka
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita12 Nishi6, Kita ku, Sapporo 060 0812, Japan
    Seikagaku 78:949-56. 2006
  36. ncbi request reprint Increased Levels of Plasma p3-Alcα35, a Major Fragment of Alcadeinα by γ-Secretase Cleavage, in Alzheimer's Disease
    Chiori Omori
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    J Alzheimers Dis 39:861-70. 2014
    ..The increase in plasma p3-Alcα35 levels may indicate an endophenotype in subjects in whom AD is due to a progressing cognitive impairment in subjects with a γ-secretase malfunction, or a disorder of the clearance of peptides. ..
  37. pmc XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms
    Akio Sumioka
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Biochem J 374:261-8. 2003
    ..These observations advance our understanding of the molecular mechanisms regulating intracellular Abeta production and the pathogenesis of Alzheimer's disease...
  38. ncbi request reprint Activity-dependent increase in beta-amyloid precursor protein mRNA expression in neurons
    Akiko Tabuchi
    Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930 0194, Japan
    Neuroreport 15:1329-33. 2004
    ..Thus, APP mRNA expression is controlled in an activity-dependent manner in neurons...
  39. ncbi request reprint Age-related modulation of γ-secretase activity in non-human primate brains
    Masaki Nishimura
    Molecular Neuroscience Research Center, Shiga University of Medical Science, Otsu, Japan
    J Neurochem 123:21-8. 2012
    ..Similar modulation may predispose aged human brains to Alzheimer's disease...
  40. doi request reprint Paths, elongation, and projections of ascending chick embryonic spinal commissural neurons after crossing the floor plate
    Takahiro Arakawa
    Laboratory of Neuroscience, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita12 Nishi6, Kita ku, Sapporo, Japan
    Brain Res 1223:25-33. 2008
    ..These direct observations of the formation of part of the spinocerebellar projections in chick will be a useful reference for future analyses of the underlying mechanisms...
  41. doi request reprint Simple and direct assembly of kymographs from movies using KYMOMAKER
    Kyoko Chiba
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060 0812, Japan
    Traffic 15:1-11. 2014
    ..KYMOMAKER is an open access program that can be easily used to analyze vesicle transport in axons by cell biologists who do not have specific knowledge of bioimage informatics. ..
  42. ncbi request reprint The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor
    Ruth C von Rotz
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    J Cell Sci 117:4435-48. 2004
    ..These data establish a role for APP in nuclear signaling, and they suggest that therapeutic strategies designed to modulate the cleavage of APP affect AICD-dependent signaling...
  43. ncbi request reprint Interaction of Alzheimer's beta -amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade
    Hidenori Taru
    Laboratory of Neurobiophysics, School of Pharmaceutical Sciences, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 277:20070-8. 2002
    ..Analysis of APP family proteins and their associated proteins is expected to contribute to understanding the molecular process of neural degeneration in Alzheimer's disease...
  44. ncbi request reprint Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism
    Hidenori Taru
    Laboratory of Neurobiophysics, School of Pharmaceutical Sciences, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 277:27567-74. 2002
    ..The present results suggest that JIP1b can directly modulate APP metabolism by interacting with the APP cytoplasmic domain, independent of its regulation of the JNK signaling cascade...
  45. ncbi request reprint Expression and characterization of the Drosophila X11-like/Mint protein during neural development
    Momoko Hase
    Laboratory of Neurobiophysics, School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Neurochem 81:1223-32. 2002
    ....
  46. doi request reprint UncI protein can mediate ring-assembly of c-subunits of FoF1-ATP synthase in vitro
    Yoko Ozaki
    Chemical Resources Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta, Midori ku, Yokohama 226 8503, Japan
    Biochem Biophys Res Commun 367:663-6. 2008
    ..Fusion of the two kinds of liposomes, one containing only unassembled c-subunit and the other only UncI, resulted in gradual formation of c-ring. Thus, UncI alone can mediate in vitro post-translational c-ring assembly...
  47. ncbi request reprint Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein
    Xiaorei Sai
    Department of Dementia Research, National Institute for Longevity Sciences, 36 3 Gengo, Morioka, Obu, Aichi 474 8522, Japan
    J Biol Chem 277:12915-20. 2002
    ..Taken together, Herp could be involved in Abeta accumulation, including the formation of senile plaques and vascular Abeta deposits...
  48. ncbi request reprint A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1
    Hidehiko Inomata
    Department of Biological Sciences, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta, Midori ku, Yokohama 226 8501, Japan
    J Biol Chem 278:22946-55. 2003
    ....
  49. ncbi request reprint Escherichia coli phage-shock protein A (PspA) binds to membrane phospholipids and repairs proton leakage of the damaged membranes
    Ryuji Kobayashi
    Chemical Resources Laboratory, Tokyo Institute of Technology, Nagatsuta 4259, Yokohama 226 8503, Japan
    Mol Microbiol 66:100-9. 2007
    ..All these effects were not observed for monomer PspA that was prepared by refolding of urea-denatured PspA. These results indicate that oligomers of PspA bind to membrane phospholipids and suppress proton leakage...
  50. ncbi request reprint Interaction of N-terminal acetyltransferase with the cytoplasmic domain of beta-amyloid precursor protein and its effect on A beta secretion
    Makoto Asaumi
    Laboratory of Neurobiophysics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033
    J Biochem 137:147-55. 2005
    ..These observations suggest that the association of APP with hARD1 and hNAT1 and/or their N-acetyltransferase activity contributes to the regulation of A beta generation...
  51. ncbi request reprint Modulation of amyloid precursor protein cleavage by cellular sphingolipids
    Naoya Sawamura
    Department of Dementia Research, National Institute for Longevity Sciences, 36 3 Gengo, Morioka, Obu, Aichi 474 8522, Japan
    J Biol Chem 279:11984-91. 2004
    ..These results suggest that not only the cellular level of cholesterol but also that of sphingolipids may be involved in the pathological process of Alzheimer's disease by modulating APP cleavage...