Tsukasa Seya


Affiliation: Hokkaido University
Country: Japan


  1. Takeda Y, Takaki H, Fukui Miyazaki A, Yoshida S, Matsumoto M, Seya T. Vaccine adjuvant ARNAX promotes mucosal IgA production in influenza HA vaccination. Biochem Biophys Res Commun. 2018;506:1019-1025 pubmed publisher
    ..These results suggested that ARNAX + antigen enhanced the immune response without inducing inflammatory toxicity for vaccination against infectious diseases. ..
  2. Seya T, Matsumoto M, Ebihara T, Oshiumi H. Functional evolution of the TICAM-1 pathway for extrinsic RNA sensing. Immunol Rev. 2009;227:44-53 pubmed publisher
    ..In this review, we discuss the fundamentals of the extrinsic dsRNA recognition system, which has evolved to induce cellular effectors to cope with dsRNA virus infection across different vertebrate species. ..
  3. Funami K, Matsumoto M, Enokizono Y, Ishii N, Tatematsu M, Oshiumi H, et al. Identification of a Regulatory Acidic Motif as the Determinant of Membrane Localization of TICAM-2. J Immunol. 2015;195:4456-65 pubmed publisher
    ..D91A/E92A of TICAM-2 selectively associates the TLR4-dependent TICAM-2 assembling, but not cytosolic TICAM-2 self-aggregation, to activate TICAM-1. ..
  4. request reprint
    Seya T, Shime H, Matsumoto M. Functional Alteration of Tumor-infiltrating Myeloid Cells in RNA Adjuvant Therapy. Anticancer Res. 2015;35:4385-92 pubmed
    ..This knowledge will be applicable to the development of an alternative immunotherapy for cancer. ..
  5. Takashima K, Oshiumi H, Matsumoto M, Seya T. TICAM-1 is dispensable in STING-mediated innate immune responses in myeloid immune cells. Biochem Biophys Res Commun. 2018;499:985-991 pubmed publisher
    ..TICAM-1 is ubiquitously expressed, even in cell types which do not express TLR3. Therefore, TICAM-1 may possess different functions depending on cell type and signaling purposes. ..
  6. Takemura R, Takaki H, Okada S, Shime H, Akazawa T, Oshiumi H, et al. PolyI:C-Induced, TLR3/RIP3-Dependent Necroptosis Backs Up Immune Effector-Mediated Tumor Elimination In Vivo. Cancer Immunol Res. 2015;3:902-14 pubmed publisher
  7. Funami K, Matsumoto M, Obuse C, Seya T. 14-3-3-zeta participates in TLR3-mediated TICAM-1 signal-platform formation. Mol Immunol. 2016;73:60-8 pubmed publisher
    ..These results suggest that 14-3-3-zeta is involved in the TLR3-TICAM-1 pathway in promoting multimerization of TICAM-1 for the formation of a TICAM-1 signalosome. ..
  8. Nakai M, Oshiumi H, Funami K, Okamoto M, Matsumoto M, Seya T, et al. Interferon (IFN) and Cellular Immune Response Evoked in RNA-Pattern Sensing During Infection with Hepatitis C Virus (HCV). Sensors (Basel). 2015;15:27160-73 pubmed publisher
    ..Here we summarize our view on the mechanism by which DCs mature to induce NK and CTL in a status of HCV infection. ..
  9. Maruyama A, Shime H, Takeda Y, Azuma M, Matsumoto M, Seya T. Pam2 lipopeptides systemically increase myeloid-derived suppressor cells through TLR2 signaling. Biochem Biophys Res Commun. 2015;457:445-50 pubmed publisher
    ..Since the increased MDSC population sustained immune-suppressive properties, our study suggests that Pam2CSK4-triggered TLR2 activation enhances the MDSC potential and suppress antitumor immune response in tumor microenvironment. ..

More Information


  1. Kasamatsu J, Takahashi S, Azuma M, Matsumoto M, Morii Sakai A, Imamura M, et al. PolyI:C and mouse survivin artificially embedding human 2B peptide induce a CD4+ T cell response to autologous survivin in HLA-A*2402 transgenic mice. Immunobiology. 2015;220:74-82 pubmed publisher
    ..These results suggest that activated, self-reactive CD4(+) helper T cells proliferate in MmSVN2B+polyI:C immunization and contribute to Th1 polarization followed by antibody production, but hardly participate in CTL induction. ..
  2. Takaki H, Takashima K, Oshiumi H, Ainai A, Suzuki T, Hasegawa H, et al. cGAMP Promotes Germinal Center Formation and Production of IgA in Nasal-Associated Lymphoid Tissue. Med Sci (Basel). 2017;5: pubmed publisher
    ..The cGAMP effect was STING-dependent. Taken together, cGAMP as an HA vaccine adjuvant promoted a STING-dependent NALT environment suitable for the enhancement of IgA production. ..
  3. Kasamatsu J, Deng M, Azuma M, Funami K, Shime H, Oshiumi H, et al. Double-stranded RNA analog and type I interferon regulate expression of Trem paired receptors in murine myeloid cells. BMC Immunol. 2016;17:9 pubmed publisher
  4. Takashima K, Takeda Y, Oshiumi H, Shime H, Okabe M, Ikawa M, et al. STING in tumor and host cells cooperatively work for NK cell-mediated tumor growth retardation. Biochem Biophys Res Commun. 2016;478:1764-71 pubmed publisher
    ..Our data show that STING induces tumor cytotoxicity by NK cells through tumor and host immune cell network to contribute to innate surveillance and suppression of tumors in vivo. ..
  5. Seya T, Matsumoto M. The extrinsic RNA-sensing pathway for adjuvant immunotherapy of cancer. Cancer Immunol Immunother. 2009;58:1175-84 pubmed publisher
    ..In this review, we focus on the potential role of dsRNA in modulating the inflammatory milieu around mDCs and tumor-associated antigens to drive specific cellular effectors against the tumor. ..
  6. Kasamatsu J, Azuma M, Oshiumi H, Morioka Y, Okabe M, Ebihara T, et al. INAM plays a critical role in IFN-γ production by NK cells interacting with polyinosinic-polycytidylic acid-stimulated accessory cells. J Immunol. 2014;193:5199-207 pubmed publisher
    ..INAM could therefore be a novel target molecule for cancer immunotherapy against IFN-γ-suppressible metastasis. ..
  7. Takeda Y, Azuma M, Matsumoto M, Seya T. Tumoricidal efficacy coincides with CD11c up-regulation in antigen-specific CD8(+) T cells during vaccine immunotherapy. J Exp Clin Cancer Res. 2016;35:143 pubmed publisher
    ..CD11c expression in CD8(+) T cells reflects anti-tumor CTL activity and would be a marker for immunotherapeutic efficacy in mouse models and probably cancer patients as well. ..
  8. Takeda Y, Kataoka K, Yamagishi J, Ogawa S, Seya T, Matsumoto M. A TLR3-Specific Adjuvant Relieves Innate Resistance to PD-L1 Blockade without Cytokine Toxicity in Tumor Vaccine Immunotherapy. Cell Rep. 2017;19:1874-1887 pubmed publisher
  9. Ono J, Shime H, Takaki H, Takashima K, Funami K, Yoshida S, et al. The TLR3/TICAM-1 signal constitutively controls spontaneous polyposis through suppression of c-Myc in Apc Min/+ mice. J Biomed Sci. 2017;24:79 pubmed publisher
    ..These results imply that the TLR3/TICAM-1 pathway inhibits polyposis through suppression of c-Myc expression and supports long survival in Apc Min/+ mice. ..
  10. Leong C, Oshiumi H, Suzuki T, Matsumoto M, Seya T. Nucleic Acid Sensors Involved in the Recognition of HBV in the Liver-Specific in vivo Transfection Mouse Models-Pattern Recognition Receptors and Sensors for HBV. Med Sci (Basel). 2015;3:16-24 pubmed publisher
    ..This review will present the current understanding of innate immunity in HBV infection and of the challenges for clearing of the HBV infection. ..
  11. Seya T, Shime H, Ebihara T, Oshiumi H, Matsumoto M. Pattern recognition receptors of innate immunity and their application to tumor immunotherapy. Cancer Sci. 2010;101:313-20 pubmed publisher
    ..In addition, we describe the mechanism by which DC-dependent natural killer activation is triggered for the induction of antitumor immunity. ..