Hidenao Sasaki

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. ncbi request reprint Phenotype variation correlates with CAG repeat length in SCA2--a study of 28 Japanese patients
    H Sasaki
    Department of Neurology, Hokkaido University, School of Medicine, Sapporo, Japan
    J Neurol Sci 159:202-8. 1998
  2. ncbi request reprint The hereditary spinocerebellar ataxias in Japan
    H Sasaki
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Cytogenet Genome Res 100:198-205. 2003
  3. ncbi request reprint Positional vertigo and macroscopic downbeat positioning nystagmus in spinocerebellar ataxia type 6 (SCA6)
    Ichiro Yabe
    Department of Neurology, Hokkaido University Graduate School of Medicine, N15 W7, Kita ku, Sapporo 060 8638, Japan
    J Neurol 250:440-3. 2003
  4. ncbi request reprint Prevalence of triplet repeat expansion in ataxia patients from Hokkaido, the northernmost island of Japan
    H Sasaki
    Department of Neurology, Hokkaido University School of Medicine, N 15 W 7, Kita ku, Sapporo, Japan
    J Neurol Sci 175:45-51. 2000
  5. doi request reprint Increased prevalence, incidence, and female predominance of multiple sclerosis in northern Japan
    Hideki Houzen
    Department of Neurology, Obihiro Kosei General Hospital, Obihiro, Japan
    J Neurol Sci 323:117-22. 2012
  6. doi request reprint Clinical features of spinal cord sarcoidosis: analysis of 17 neurosarcoidosis patients
    Ken Sakushima
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Neurol 258:2163-7. 2011
  7. doi request reprint Decreased IL-10 production mediated by Toll-like receptor 9 in B cells in multiple sclerosis
    Makoto Hirotani
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Neuroimmunol 221:95-100. 2010
  8. doi request reprint Mapping of autosomal dominant cerebellar ataxia without the pathogenic PPP2R2B mutation to the locus for spinocerebellar ataxia 12
    Kazunori Sato
    Department of Neurology, Graduate School of Medicine, Hokkaido University, Sapporo 060 8638, Japan
    Arch Neurol 67:1257-62. 2010
  9. doi request reprint Writing errors in ALS related to loss of neuronal integrity in the anterior cingulate gyrus
    Ichiro Yabe
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Neurol Sci 315:55-9. 2012
  10. doi request reprint Decreased interferon-α production in response to CpG DNA dysregulates cytokine responses in patients with multiple sclerosis
    Makoto Hirotani
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Clin Immunol 143:145-51. 2012

Detail Information

Publications93

  1. ncbi request reprint Phenotype variation correlates with CAG repeat length in SCA2--a study of 28 Japanese patients
    H Sasaki
    Department of Neurology, Hokkaido University, School of Medicine, Sapporo, Japan
    J Neurol Sci 159:202-8. 1998
    ..Parkinsonism was seen in a man homozygote for SCA2 mutation. The clinical variety of SCA2 is apparently influenced by the size of the mutant allele, as is the case in other CAG repeat disorders...
  2. ncbi request reprint The hereditary spinocerebellar ataxias in Japan
    H Sasaki
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Cytogenet Genome Res 100:198-205. 2003
    ..Among the recessive SCAs, patients with AVED and EAOH have been detected. However, FRDA associated with GAA repeat expansion in the frataxin gene has not been reported so far...
  3. ncbi request reprint Positional vertigo and macroscopic downbeat positioning nystagmus in spinocerebellar ataxia type 6 (SCA6)
    Ichiro Yabe
    Department of Neurology, Hokkaido University Graduate School of Medicine, N15 W7, Kita ku, Sapporo 060 8638, Japan
    J Neurol 250:440-3. 2003
    ..Our findings indicated that DPN is a distinct part of the clinical presentation of SCA6, showing that vestibular cerebellum is more affected in SCA6 than other types of degenerative ataxia...
  4. ncbi request reprint Prevalence of triplet repeat expansion in ataxia patients from Hokkaido, the northernmost island of Japan
    H Sasaki
    Department of Neurology, Hokkaido University School of Medicine, N 15 W 7, Kita ku, Sapporo, Japan
    J Neurol Sci 175:45-51. 2000
    ..Comparison of our results with those from other centers handling SCA showed that MJD is prevalent throughout Japan, but the frequencies of other dominant SCAs differ considerably even within Japan...
  5. doi request reprint Increased prevalence, incidence, and female predominance of multiple sclerosis in northern Japan
    Hideki Houzen
    Department of Neurology, Obihiro Kosei General Hospital, Obihiro, Japan
    J Neurol Sci 323:117-22. 2012
    ....
  6. doi request reprint Clinical features of spinal cord sarcoidosis: analysis of 17 neurosarcoidosis patients
    Ken Sakushima
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Neurol 258:2163-7. 2011
    ..The results of this study indicate that diagnosis of spinal cord sarcoidosis requires careful evaluation...
  7. doi request reprint Decreased IL-10 production mediated by Toll-like receptor 9 in B cells in multiple sclerosis
    Makoto Hirotani
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Neuroimmunol 221:95-100. 2010
    ..Our results indicate that TLR9-mediated IL-10 production by B cells was significantly decreased in MS, and this decrease is likely due to decreased TLR9 expression in memory B cells, suggesting a role of TLR9 in immunoregulation in MS...
  8. doi request reprint Mapping of autosomal dominant cerebellar ataxia without the pathogenic PPP2R2B mutation to the locus for spinocerebellar ataxia 12
    Kazunori Sato
    Department of Neurology, Graduate School of Medicine, Hokkaido University, Sapporo 060 8638, Japan
    Arch Neurol 67:1257-62. 2010
    ..To map the disease locus and to identify a gene mutation in a Japanese family with autosomal dominant cerebellar ataxia...
  9. doi request reprint Writing errors in ALS related to loss of neuronal integrity in the anterior cingulate gyrus
    Ichiro Yabe
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Neurol Sci 315:55-9. 2012
    ..1). The results showed that writing errors in our patients with ALS were related to dysfunction in the anterior cingulate gyrus...
  10. doi request reprint Decreased interferon-α production in response to CpG DNA dysregulates cytokine responses in patients with multiple sclerosis
    Makoto Hirotani
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Clin Immunol 143:145-51. 2012
    ..These results suggest that CpG DNA-induced decreased IFN-α production causes pro-inflammatory cytokine secretion, and either IFN-α or IFN-β induces anti-inflammatory cytokine secretion in the adaptive immune system in MS...
  11. doi request reprint Downbeat positioning nystagmus is a common clinical feature despite variable phenotypes in an FHM1 family
    Ichiro Yabe
    Department of Neurology, Hokkaido University Graduate School of Medicine, N15 W7 Kita ku, Sapporo 060 8638, Japan
    J Neurol 255:1541-4. 2008
    ..Although clinical features associated with the T666M CACNA1A mutation are highly variable, downbeat positioning nystagmus may be an important clinical feature of this disease...
  12. ncbi request reprint Brain SPECT analysis by 3D-SSP and phenotype of Parkinson's disease
    Yasunori Mito
    Department of Neurology, Asahikawa Red Cross Hospital, 1 1, Akebono, Asahikawa, Hokkaido, 070 8530, Japan
    J Neurol Sci 241:67-72. 2006
    ..We therefore investigated the association of phenotypes in untreated PD with brain perfusion on SPECT using three-dimensional stereotactic surface projection (3D-SSP) technique...
  13. doi request reprint Genetic analysis of two Japanese families with progressive external ophthalmoplegia and parkinsonism
    Kazunori Sato
    Department of Neurology, Hokkaido University Graduate School of Medicine, N15W7, Kita ku, Sapporo 060 8638, Japan
    J Neurol 258:1327-32. 2011
    ..Progressive external ophthalmoplegia and parkinsonism are genetically heterogenous disorders, and part of this syndrome may be caused by mutations in other, unknown genes...
  14. ncbi request reprint MSA-C is the predominant clinical phenotype of MSA in Japan: analysis of 142 patients with probable MSA
    Ichiro Yabe
    Department of Neurology, Hokkaido University, Graduate School of Medicine, Sapporo, Hokkaido 060 8368, Japan
    J Neurol Sci 249:115-21. 2006
    ..This difference of disease manifestations between ethnic groups suggests that genetic factors may influence the clinical phenotype of MSA...
  15. doi request reprint Associations between multiple system atrophy and polymorphisms of SLC1A4, SQSTM1, and EIF4EBP1 genes
    Hiroyuki Soma
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan
    Mov Disord 23:1161-7. 2008
    ..This study revealed genetic associations of SLC1A4, SQSTM1, and EIF4EBP1 with MSA. These results may lend genetic support to the hypothesis that oxidative stress is associated with the pathogenesis of MSA...
  16. pmc Hyperintense putaminal rim at 1.5 T: prevalence in normal subjects and distinguishing features from multiple system atrophy
    Khin K Tha
    Department of Radiobiology and Medical Engineering, Hokkaido University Graduate School of Medicine, N 15, W 7, Sapporo 060 8638, Japan
    BMC Neurol 12:39. 2012
    ..5 T is not known. This study aimed to determine whether HPR could be observed in normal subjects at 1.5 T; and if so, to establish its prevalence, the MRI characteristics, and the features which distinguish from HPR in MSA patients...
  17. ncbi request reprint [A case of intravascular lymphoma with a longitudinal spinal lesion diagnosed by multiple biopsies]
    Shinichi Shirai
    Department of Neurology, Hokkaido University Graduate School of Medicine
    Rinsho Shinkeigaku 52:336-43. 2012
    ..The results of this study confirm that sufficient systemic investigation by using tissue biopsy specimens should be performed in order to confirm the diagnosis of IVL myelopathy...
  18. pmc TRIM67 protein negatively regulates Ras activity through degradation of 80K-H and induces neuritogenesis
    Hiroaki Yaguchi
    Department of Biochemistry, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060 8638, Japan
    J Biol Chem 287:12050-9. 2012
    ..These findings suggest that TRIM67 regulates Ras signaling via degradation of 80K-H, leading to neural differentiation including neuritogenesis...
  19. ncbi request reprint [Successful cyclosporine treatment in 2 patients with refractory CIDP, involving monitoring of both AUC(0-4h) and trough levels]
    Akiko Takeuchi
    Department of Neurology, Hokkaido University Graduate School of Medicine
    Rinsho Shinkeigaku 52:172-7. 2012
    ..Monitoring both AUC(0-4 h) and trough levels of CYA seems to be a better option than monitoring the trough level alone because it leads to improved estimation of the efficacy and safety of CYA treatment in the case of CIDP patients...
  20. doi request reprint Pathological study of subacute autoimmune encephalopathy with anti-AQP4 antibodies in a pregnant woman
    Hiroaki Yaguchi
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan
    Mult Scler 18:683-7. 2012
    ..Moreover, loss of AQP4 was observed in the gray matter. The presence of anti-AQP4 antibodies, and the pathology, led to the diagnosis of anti-AQP4 antibodies-related encephalopathy...
  21. ncbi request reprint Role of p53 in neurotoxicity induced by the endoplasmic reticulum stress agent tunicamycin in organotypic slice cultures of rat spinal cord
    Jun Tashiro
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Hokkaido, Japan
    J Neurosci Res 85:395-401. 2007
    ..This difference might be a clue to the mechanism of the stress-response pathway and might also contribute to the potential application of p53 inhibitors for the treatment of spinal cord diseases, including amyotrophic lateral sclerosis...
  22. doi request reprint MRI and pathological findings of rheumatoid meningitis
    Masaaki Matsushima
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    J Clin Neurosci 17:129-32. 2010
    ..RM is a treatable disease and in this patient RM was diagnosed on the basis of biopsy findings...
  23. ncbi request reprint Secretion of DJ-1 into the serum of patients with Parkinson's disease
    Chinatsu Maita
    Graduate School of Agriculture, Hokkaido University, Kita ku, Sapporo 060 8589, Japan
    Neurosci Lett 431:86-9. 2008
    ..There was no significant difference between the levels of secreted DJ-1 in two groups, and correlations of levels of secreted DJ-1 with age, clinical severity of PD and level of oxidative stress were not found...
  24. ncbi request reprint Estrogens as potential therapeutic agents in multiple sclerosis
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kitaku, Sapporo, Japan
    Cent Nerv Syst Agents Med Chem 9:87-94. 2009
    ..In this review paper, we discuss increasing evidence that points to a link between estrogen and MS. We also analyze the therapeutic potential of estrogens in MS and review current genetic studies on ER...
  25. ncbi request reprint Spectrum and prevalence of autosomal dominant spinocerebellar ataxia in Hokkaido, the northern island of Japan: a study of 113 Japanese families
    Rehana Basri
    Department of Neurology, Graduate School of Medicine, Hokkaido University, N15W7 Kita ku, Sapporo 060 8368, Japan
    J Hum Genet 52:848-55. 2007
    ..The present study validates the prevalence of genetically distinct ADCA subtypes based on ethnic origin and geographical variation, and shows that 16q-linked ADCA has strong hereditary effects in patients with ADCAs in Japan...
  26. ncbi request reprint Efficacy of intravenous cyclophosphamide therapy for neuromyelitis optica spectrum disorder
    Hiroaki Yaguchi
    Department of Neurology, Hokkaido University Graduate School of Medicine, Japan
    Intern Med 52:969-72. 2013
    ..In this study, we report the efficacy of intravenous cyclophosphamide (IVCY) therapy for NMOSD...
  27. doi request reprint Clinical, pathological, and genetic mutation analysis of sporadic inclusion body myositis in Japanese people
    Huaying Cai
    Department of Neurology, Hokkaido University, Graduate School of Medicine, N15W7, Kita ku, Sapporo, 060 8638, Japan
    J Neurol 259:1913-22. 2012
    ..Cumulatively, these findings have expanded our understanding of the molecular background of sIBM. However, we advocate further clinicopathology and investigation of additional candidate genes in a larger cohort...
  28. doi request reprint Progressive anterior operculum syndrome due to FTLD-TDP: a clinico-pathological investigation
    Mika Otsuki
    School of Psychological Science, Health Sciences University of Hokkaido, Kita ku, Sapporo, Japan
    J Neurol 257:1148-53. 2010
    ..However, neuronal loss with gliosis was more prominent in the inferior part of the motor cortices, bilaterally. Progressive anterior operculum syndrome could be classified as a variant of FTLD-TDP...
  29. ncbi request reprint Cystatin C in cerebrospinal fluid as a biomarker of ALS
    Sachiko Tsuji-Akimoto
    Department of Neurology, Graduate School of Medicine, Hokkaido University, Sapporo City, Hokkaido, Japan
    Neurosci Lett 452:52-5. 2009
    ..control subjects: p = 0.014 and ALS patients vs. polyneuropathy patients: p = 0.024). Cystatin C may be a useful biomarker of ALS and can be used to distinguish between ALS and polyneuropathy...
  30. doi request reprint Clinical characterization and successful treatment of 6 patients with Churg-Strauss syndrome-associated neuropathy
    Masakazu Nakamura
    Department of Neurology, Hokkaido University Graduate School of Medicine, N15W7, Kita ku, Sapporo 060 8638, Japan
    Clin Neurol Neurosurg 111:683-7. 2009
    ..To confirm the reported findings and clarify unknown clinical features of Churg-Strauss syndrome (CSS)-associated neuropathy and design appropriate treatment...
  31. doi request reprint Microstructural white matter abnormalities of multiple system atrophy: in vivo topographic illustration by using diffusion-tensor MR imaging
    Khin K Tha
    Department of Radiology, Hokkaido University Graduate School of Medicine, N 15, W 7, Kita ku, Sapporo 060 8638, Japan
    Radiology 255:563-9. 2010
    ..To determine whether diffusion-tensor (DT) imaging can demonstrate microstructural white matter abnormalities of multiple system atrophy (MSA) and to correlate these imaging findings with clinical signs and symptoms...
  32. doi request reprint FDG-PET SUV can distinguish between spinal sarcoidosis and myelopathy with canal stenosis
    Ken Sakushima
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo, 060 8638, Japan
    J Neurol 258:227-30. 2011
    ..FDG-PET is informative for the accurate diagnosis of spinal cord sarcoidosis and may enable clinicians to start treatment at an earlier stage...
  33. doi request reprint Brain Regions Associated With Cognitive Impairment in Patients With Parkinson Disease: Quantitative Analysis of Cerebral Blood Flow Using 123I Iodoamphetamine SPECT
    Naoya Hattori
    From the Departments of Molecular Imaging, Neurology, and Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Clin Nucl Med 38:315-20. 2013
    ..The purpose of this study was to localize the cerebral regions associated with cognitive impairment in patients with PD using quantitative SPECT...
  34. ncbi request reprint [Treatment of intractable tuberculous meningitis using intrathecal isoniazid administration and steroid pulse therapy; a report of two cases]
    Ikuko Takahashi
    Department of Neurology, Hokkaido University Graduate School of Medicine
    Rinsho Shinkeigaku 52:551-6. 2012
    ..However, our experience in these cases showed amelioration of the symptoms leading to the rehabilitation of these patients in society...
  35. doi request reprint Estimation of skeletal muscle energy metabolism in Machado-Joseph disease using (31)P-MR spectroscopy
    Ichiro Yabe
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Mov Disord 26:165-8. 2011
    ..34, P = 0.04). The MJD group also showed a reduction in V(max) over the course of 2 years (P < 0.05). These data suggest that this noninvasive measurement of muscle energy metabolism may represent a surrogate marker for MJD...
  36. ncbi request reprint Unusual retinal phenotypes in an SCA7 family
    Hirofumi Inaba
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo
    Intern Med 48:1461-4. 2009
    ..He was diagnosed with SCA7 by genetic analysis. His ophthalmologic examination showed retinal degeneration without pigmented spots, which is different from those of retinal phenotypes previously described in SCA7...
  37. ncbi request reprint TNF-related apoptosis inducing ligand (TRAIL) gene polymorphism in Japanese patients with multiple sclerosis
    Seiji Kikuchi
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo 060 8638, Japan
    J Neuroimmunol 167:170-4. 2005
    ..453-3.943). There were no significant associations between +1595 polymorphism and the clinical features of MS. The results indicate that the presence of the CC genotype at position 1595 in exon 5 represents a higher risk of MS...
  38. doi request reprint Transient subacute cerebellar ataxia in a patient with Lambert-Eaton myasthenic syndrome after intracranial aneurysm surgery
    Masakazu Nakamura
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo 060 8368, Japan
    Clin Neurol Neurosurg 110:480-3. 2008
    ..More cases are needed to investigate the mechanisms involved. The subacute CA and LEMS in this patient have remained comparatively silent after the withdrawal of steroids, and we are continuing to observe her condition...
  39. doi request reprint 3D neuromelanin-sensitive magnetic resonance imaging with semi-automated volume measurement of the substantia nigra pars compacta for diagnosis of Parkinson's disease
    Kimihiro Ogisu
    Department of Radiology, Hokkaido University Graduate School of Medicine, N 15, W 7, Kita ku, Sapporo, Hokkaido 060 8638, Japan
    Neuroradiology 55:719-24. 2013
    ..In this study, we aimed to apply a 3D turbo field echo (TFE) sequence for neuromelanin-sensitive MRI and to evaluate the diagnostic performance of semi-automated method for measurement of SNc volume in patients with PD...
  40. doi request reprint Age at onset influences on wide-ranged clinical features of sporadic amyotrophic lateral sclerosis
    Naoki Atsuta
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Neurol Sci 276:163-9. 2009
    ..To profile the detailed clinical features of sporadic amyotrophic lateral sclerosis (ALS) on large-scale samples in Japan...
  41. ncbi request reprint [Reliability of blood gas analyzers for measuring lactate levels in cerebrospinal fluid]
    Ken Sakushima
    Department of Neurology, Hokkaido University Graduate School of Medicine
    Rinsho Shinkeigaku 49:275-7. 2009
    ..In conclusion, we consider that rapid measurement of the lactate and glucose levels in CSF samples by blood gas analyzers can be considerably reliable in clinical practice...
  42. doi request reprint Idiopathic hypoglossal nerve laceration detected by high-resolution three-dimensional constructive interference in steady state magnetic resonance imaging
    Ken Sakushima
    Department of Neurology, Hokkaido University Graduate School of Medicine, and Department of Radiology, Hokkaido University Hospital, Sapporo, Japan
    J Neuroimaging 21:e177-9. 2011
    ..In such patients, the cause of the defect is not always apparent and 3-dimensional CISS MRI may resolve this issue...
  43. doi request reprint Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): a multicentre, randomised, double-blind, placebo-controlled trial
    Masahisa Katsuno
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Lancet Neurol 9:875-84. 2010
    ..We aimed to assess the efficacy and safety of leuprorelin for spinal and bulbar muscular atrophy...
  44. ncbi request reprint Treatment of cerebellar ataxia with 5-HT1A agonist
    Asako Takei
    Hokuyukai Neurology Hospital, Niju yon ken, Nishi ku, Sapporo, Japan
    Cerebellum 4:211-5. 2005
    ..Responsive patients exhibited only mild ataxia. The doses of 5-HT1A agonists that have been used successfully ranged from 12.5 mg/day to 60 mg/day (or 1 mg/kg), and were well tolerated by most patients...
  45. ncbi request reprint [Reliability of the Japanese version of the Scale for the Assessment and Rating of Ataxia (SARA)]
    Kazunori Sato
    Neurology, Hokkaido University Graduate School of Medicine, Japan
    Brain Nerve 61:591-5. 2009
    ..After obtaining the permission, original SARA was translated into Japanese...
  46. ncbi request reprint Chronic inflammatory demyelinating polyneuropathy after treatment with interferon-alpha
    Makoto Hirotani
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo
    Intern Med 48:373-5. 2009
    ..This case may therefore provide an important clue to understand the immune mechanism of CIDP and IFN-alpha...
  47. ncbi request reprint [Progressive cerebellar ataxia with euthyroid Hashimoto's disease--implication of autoantibodies associated with Hashimoto's disease in progressive cerebellar ataxia]
    Ichiro Yabe
    Department of Neurology, Hokkaido University Graduate School of Medicine
    Rinsho Shinkeigaku 48:640-5. 2008
    ..Although Hashimoto's disease may associate with cerebellar ataxia because cortical cerebellar atrophy is a heterogeneous condition, this association is not clear at present...
  48. doi request reprint Adult Leigh disease without failure to thrive
    Ken Sakushima
    Department of Neurology, Hokkaido University Graduate School of Medicine, Hokkaido, Japan
    Neurologist 17:222-7. 2011
    ..We also conducted a systemic literature search on adult LD and integrated its various manifestations to arrive at a diagnostic procedure for adult LD...
  49. ncbi request reprint [Re-evaluation of clinical presentation in Spinocerebellar ataxia type 6]
    Ichiro Yabe
    Department of Neurology, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    No To Shinkei 55:299-306. 2003
  50. ncbi request reprint Therapeutic potential of vitamin D for multiple sclerosis
    Masaaki Niino
    Department of Neurology, Hokkaido University Hospital, Kita 14, Nishi 5, Kita ku, Sapporo 060 8648 Japan
    Curr Med Chem 15:499-505. 2008
    ..This review also discusses the therapeutic potential of vitamin D for treating MS...
  51. ncbi request reprint X-linked Charcot-Marie-Tooth disease (CMTX) in a severely affected female patient with scattered lesions in cerebral white matter
    Rehana Basri
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo
    Intern Med 46:1023-7. 2007
    ..The existence of a female patient with severe clinical symptoms may show that gain of function mechanism also leads to the disorders seen in these patients...
  52. ncbi request reprint Abnormal brain MRI signals in the splenium of the corpus callosum, basal ganglia and internal capsule in a suspected case with tuberculous meningitis
    Makoto Hirotani
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo
    Intern Med 46:505-9. 2007
    ..This valuable case suggests that an immune mechanism contributed to the occurrence of central nervous system symptoms associated with tuberculous meningitis...
  53. ncbi request reprint Spinocerebellar ataxia type 14 caused by a mutation in protein kinase C gamma
    Ichiro Yabe
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Arch Neurol 60:1749-51. 2003
    ..Different PRKCG mutations were found in another family with SCA and in a sporadic case from the United States. Axial myoclonus was not observed in any of these US families...
  54. ncbi request reprint Usefulness of the Scale for Assessment and Rating of Ataxia (SARA)
    Ichiro Yabe
    Department of Neurology, Hokkaido Graduate School of Medicine, N15 W7 Kita ku, Sapporo 060 8638, Japan
    J Neurol Sci 266:164-6. 2008
    ....
  55. ncbi request reprint [Successful treatment of a Lambert-Eaton myasthenic syndrome patient with 3,4-diaminopyridine]
    Masaaki Matsushima
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo
    Nihon Naika Gakkai Zasshi 96:1709-11. 2007
  56. ncbi request reprint [Revival of old diagnostic markers in the cerebrospinal fluid for the detection of infectious meningitis]
    Ken Sakushima
    Department of Neurology, Hokkaido University Graduate School of Medicine
    Rinsho Shinkeigaku 52:6-11. 2012
    ....
  57. doi request reprint Five-year follow-up with low-dose tacrolimus in patients with myasthenia gravis
    Naoya Minami
    Department of Neurology, Hokkaido Medical Center, Sapporo, Japan
    J Neurol Sci 300:59-62. 2011
    ..Tacrolimus is an important option for treatment of MG; however, careful management is needed for long-term treatment with this drug...
  58. doi request reprint Writing errors as a result of frontal dysfunction in Japanese patients with amyotrophic lateral sclerosis
    Sachiko Tsuji-Akimoto
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Neurol 257:2071-7. 2010
    ..The most frequent type of error was an omission of kana, the next most common was a missing subject. Writing errors might be a specific deficit for some non-demented ALS patients...
  59. ncbi request reprint Recent advances in genetic analysis of multiple sclerosis: genetic associations and therapeutic implications
    Masaaki Niino
    Department of Neurology, Hokkaido University Hospital, Kita 14, Nishi 5, Kita ku, Sapporo 060 8648, Japan
    Expert Rev Neurother 7:1175-88. 2007
    ..Newer techniques and methods of analysis will hopefully result in better screening of individuals who are at highest risk and novel treatments...
  60. doi request reprint Nationwide survey on the epidemiology of syringomyelia in Japan
    Ken Sakushima
    Department of Neurology, Hokkaido University Graduate School of Medicine, Hokkaido, Japan
    J Neurol Sci 313:147-52. 2012
    ..The widespread availability of magnetic resonance imaging (MRI) in Japan has allowed for easy identification of syrinxes. The aim of this study was to survey the clinicoepidemiological characteristics of syringomyelia in Japan...
  61. ncbi request reprint [Gliomatosis cerebri with multifocal progressive lesions on MRI]
    Ken Sakushima
    Department of Neurology, Hokkaido University Graduate School of Medicine
    Rinsho Shinkeigaku 51:145-8. 2011
    ..However, the present case showed unusual multifocal manifestations in brain MRI. Therefore, histopathological examination must be taken into account for a proper diagnosis...
  62. ncbi request reprint Brain 3D-SSP SPECT analysis in dementia with Lewy bodies, Parkinson's disease with and without dementia, and Alzheimer's disease
    Yasunori Mito
    Department of Neurology, Asahikawa Red Cross Hospital, 1 1, Akebono, Asahikawa, Hokkaido 070 8530, Japan
    Clin Neurol Neurosurg 107:396-403. 2005
    ....
  63. ncbi request reprint Effects of tandospirone on "5-HT1A receptor-associated symptoms" in patients with Machado-Josephe disease: an open-label study
    Asako Takei
    Hokuyukai Neurology Hospital, Nishi ku, Sapporo, Japan
    Clin Neuropharmacol 27:9-13. 2004
    ....
  64. ncbi request reprint [Nationwide questionnaire study in "the Model Core Curriculum" and current status for the undergraduate education in neurology]
    Hidenao Sasaki
    Department of Neurology, Hokkaido University Graduate School of Medicine
    Rinsho Shinkeigaku 48:556-62. 2008
    ....
  65. ncbi request reprint Heredity in multiple system atrophy
    Hiroyuki Soma
    Department of Neurology, Hokkaido University, Graduate School of Medicine, and Hokuyukai Neurology Hospital, Sapporo, Hokkaido, 060 8368, Japan
    J Neurol Sci 240:107-10. 2006
    ..The results indicated that one of them had a family history of MSA. Although the familial presence of neurodegenerative disorders is rare in MSA patients, the existence of such cases suggests that MSA may have a genetic background...
  66. ncbi request reprint Early detection of subacute sclerosing panencephalitis by high b-value diffusion-weighted imaging: a case report
    Khin Khin Tha
    Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Comput Assist Tomogr 30:126-30. 2006
    ..The signal abnormalities were difficult to identify on other magnetic resonance imaging sequences, including routine DWI. High b-value DWI could be valuable for earlier detection of subacute sclerosing panencephalitis...
  67. ncbi request reprint Four mutations of the spastin gene in Japanese families with spastic paraplegia
    Rehana Basri
    Department of Neurology, Graduate School of Medicine, Hokkaido University, Kita ku, Sapporo 060 8368, Japan
    J Hum Genet 51:711-5. 2006
    ..Previous reports and our results suggest that the frequency of SPAST mutations is higher among Japanese patients with autosomal dominant HSP, although SPAST mutations are also observed in patients with sporadic spastic paraplegia...
  68. pmc Copy number loss of (src homology 2 domain containing)-transforming protein 2 (SHC2) gene: discordant loss in monozygotic twins and frequent loss in patients with multiple system atrophy
    Hidenao Sasaki
    Department of Neurology, Graduate School of Medicine, Hokkaido University, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    Mol Brain 4:24. 2011
    ..To identify genomic alterations increasing the risk for MSA, we examined a pair of monozygotic (MZ) twins discordant for the MSA phenotype and 32 patients with MSA...
  69. ncbi request reprint [Idiopathic intracranial hypertension without headache detected during a routine health check]
    Ken Sakushima
    Department of Neurology, Hokkaido University Graduate School of Medicine
    Rinsho Shinkeigaku 48:430-2. 2008
    ..Treatment with acetazolamide reduced the cerebrospinal pressure. We suggest that examination of the optic fundi is sufficient to diagnose both IIH without headache and IIH with atypical symptoms...
  70. ncbi request reprint [A case of primary diffuse leptomeningeal gliomatosis, clinically indistinguishable from metastatic meningeal carcinomatosis]
    Fumihito Nakano
    Department of Neurology, Hokkaido University Graduate School of Medicine
    Rinsho Shinkeigaku 51:197-202. 2011
    ....
  71. ncbi request reprint Scapular winging as a symptom of cervical flexion myelopathy
    Hiroaki Yaguchi
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo
    Intern Med 46:511-3. 2007
    ..Here, we report a case of unilateral, proximal upper limb atrophy with scapular winging, attributed to middle cervical flexion myelopathy...
  72. ncbi request reprint Proteasome inhibition induces selective motor neuron death in organotypic slice cultures
    Sachiko Tsuji
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    J Neurosci Res 82:443-51. 2005
    ..01). We postulate that proteasome inhibition is an excellent model for studying the mechanisms underlying selective motor neuron death and searching for new therapeutic strategies in the treatment of ALS...
  73. ncbi request reprint Late onset ataxia phenotype in dentatorubro-pallidoluysian atrophy (DRPLA)
    Ichiro Yabe
    Department of Neurology, Hokkaido University School of Medicine, N 15 W 7, Kita ku, Sapporo 060 8638, Japan
    J Neurol 249:432-6. 2002
    ..Our experience implies that DRPLA must be taken into account in the differential diagnosis of late onset ataxic disorders, since it can easily be overlooked...
  74. doi request reprint Memory and naïve B-cell subsets in patients with multiple sclerosis
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Neurosci Lett 464:74-8. 2009
    ..These results indicate that memory and naïve B-cell subsets, especially CD86(+) naïve B cells, CCR5(+) naïve B cells, and CD5(+) memory B cells, might be useful in the study of the pathogenesis of and therapy for MS...
  75. ncbi request reprint Update on the treatment options for multiple sclerosis
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Expert Rev Clin Immunol 6:77-88. 2010
    ..Here, we review the recent progress in current therapeutic strategies for MS, and the potential options for future MS treatment...
  76. ncbi request reprint [Differential diagnosis of spinocerebellar ataxia]
    Hidenao Sasaki
    Department of Neurology, Hokkaido University Graduate School of Medicine
    Rinsho Shinkeigaku 42:1069-72. 2002
    ..However, cases meeting the criteria of autonomic disturbances are confined to the advanced stage of the illness or rare cases starting with obvious dysautonomia. These problems indicate that the criteria need further adjustment...
  77. ncbi request reprint Brain activation during detrusor overactivity in patients with Parkinson's disease: a positron emission tomography study
    Takeya Kitta
    Department of Urology, Nuclear Medicine and Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Urol 175:994-8. 2006
    ..We hypothesized that brain activation patterns in response to bladder filling would be different in patients with Parkinson's disease...
  78. ncbi request reprint [Model core curriculum in neurology--current status and problems after its application to the medical education program]
    Hidenao Sasaki
    Department of Neurology, Hokkaido University Graduate School of Medicine
    Rinsho Shinkeigaku 47:889-92. 2007
    ..The list of curriculum needs additional neurological disorders and symptoms commonly seen, and that clinical clerkship to neurology must be taken into account as one of compulsory rather than optional course...
  79. ncbi request reprint [Clinical feature and molecular genetics of hereditary spinocerebellar ataxia]
    Hidenao Sasaki
    Department of Neurology, Hokkaido University Graduate School of Medicine
    Rinsho Shinkeigaku 47:795-800. 2007
    ....
  80. ncbi request reprint [Multiple system atrophy--update]
    Hidenao Sasaki
    Department of Neurology, Division of Neurological Science, Hokkaido University Graduate School of Medicine
    Rinsho Shinkeigaku 44:979-81. 2004
    ..These laboratory diagnostic procedures can contribute to improve reliability of the diagnosis, and needs to be taken into account when preventive measures become available...
  81. ncbi request reprint [Clinical studies on multiple system atrophy]
    Hidenao Sasaki
    Nihon Naika Gakkai Zasshi 94:1409-15. 2005
  82. ncbi request reprint No association between FMR1 premutations and multiple system atrophy
    Ichiro Yabe
    J Neurol 251:1411-2. 2004
  83. doi request reprint Baló's concentric sclerosislike lesion in the brainstem of a multiple sclerosis patient
    Richiro Kishimoto
    J Neurol 255:760-1. 2008
  84. ncbi request reprint CTLA-4 gene polymorphism is not associated with conventional multiple sclerosis in Japanese
    Toshiyuki Fukazawa
    Hokuyukai Neurology Hospital, Niju Yon Ken 2 2 4 30, Nishi ku, Sapporo 063 0802, Japan
    J Neuroimmunol 159:225-9. 2005
    ....
  85. ncbi request reprint Hodgkin's disease-related central nervous system angiopathy presenting as reversible posterior leukoencephalopathy
    Yusei Miyazaki
    Department of Neurology, Sapporo City General Hospital
    Intern Med 43:1005-7. 2004
    ..We describe herein a case of Hodgkin's disease (HD)-related central nervous system (CNS) angiitis with neuroimaging finding suggestive of RPLS. The pathophysiology of RPLS in cases with CNS angiitis is discussed...
  86. ncbi request reprint Femoral neuropathy induced by a low-grade myofibroblastic sarcoma of the groin
    Yasutaka Tajima
    J Neurol 252:1416-7. 2005
  87. ncbi request reprint [Clinical manifestation of ataxia in mitochondrial disorders]
    Hidenao Sasaki
    Section of Neurology, Division of Neurological Science, Hokkaido University Graduate School of Medicine
    Nihon Rinsho 60:511-4. 2002
  88. ncbi request reprint [Progress in the field of neurology in the last 100 years: Triplet repeat diseases]
    Kunio Tashiro
    Nihon Naika Gakkai Zasshi 91:2263-7. 2002
  89. ncbi request reprint Physical map and haplotype analysis of 16q-linked autosomal dominant cerebellar ataxia (ADCA) type III in Japan
    Mingshun Li
    Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Hum Genet 48:111-8. 2003
    ..8-Mb region, spanning markers GGAA05 and D16S3095. We present here a newly refined critical interval of 16q-ADCA type III/SCA4. Data of 11 new DNA markers on 16q22.1 would also be useful for other research of genes mapped to this region...
  90. ncbi request reprint Herpes simplex virus encephalitis presenting with cerebral infarction-like signs and neuroimages
    Yasunori Mito
    Neurology, Asahikawa Red Cross Hospital, Asahikawa 070 8530, Japan
    Hokkaido Igaku Zasshi 80:185-9. 2005
    ..Laboratory findings including cerebrospinal fluid established a diagnosis of HSV encephalitis, and a state of apalic syndrome persisted despite aggressive antiviral therapy...
  91. ncbi request reprint CSF pleocytosis and expansion of spinal lesions in Japanese multiple sclerosis with special reference to the new diagnostic criteria
    Toshiyuki Fukazawa
    Hokuyukai Neurology Hospital, Niju Yon Ken 2 2 4 30, Nishi ku, Sapporo 063 0802, Japan
    J Neurol 252:824-9. 2005
    ....
  92. ncbi request reprint Attack-related severity: a key factor in understanding the spectrum of idiopathic inflammatory demyelinating disorders
    Toshiyuki Fukazawa
    Hokuyukai Neurology Hospital, Niju Yon Ken 2 2 4 30, Nishi ku, Sapporo 063 0802, Japan
    J Neurol Sci 225:71-8. 2004
    ..Attack-related severity may be an important factor if validated by prospective studies defining criteria and establishing relationships to disease course and treatment regimens...
  93. ncbi request reprint Degeneration of the inferior olive in spinocerebellar ataxia 6 may depend on disease duration: report of two autopsy cases and statistical analysis of autopsy cases reported to date
    Kuniaki Tsuchiya
    Department of Laboratory Medicine and Pathology, Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan
    Neuropathology 25:125-35. 2005
    ..Furthermore, a log-rank test on the two groups disclosed a significant difference (P=0.0450). We postulate that the neuronal loss of the inferior olive in SCA6 may depend on disease duration...