M Saito

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. Pharmacokinetics of zonisamide and drug interaction with phenobarbital in dogs
    K Orito
    Department of Pharmacology, School of Veterinary Medicine, Azabu University, Kanagawa, Japan
    J Vet Pharmacol Ther 31:259-64
  2. Stress distribution of abutments and base displacement with precision attachment- and telescopic crown-retained removable partial dentures
    M Saito
    Removable Prosthodontics and Stomatognathic Rehabilitation, Department of Oral Functional Science, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan
    J Oral Rehabil 30:482-7
  3. Genetic analyses of essential genes in cytological region 61D1-2 to 61F1-2 of Drosophila melanogaster
    M Saito
    Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Kawaguchi, Saitama 332 0012, Japan
    Mol Genet Genomics 268:446-54
  4. LPS-stimulated human gingival fibroblasts inhibit the differentiation of monocytes into osteoclasts through the production of osteoprotegerin
    T Nagasawa
    Tokyo Medical and Dental University, Graduate School, Department of Hard Tissue Engineering Periodontology, Tokyo, Japan
    Clin Exp Immunol 130:338-44
  5. Cloning of canine 21-hydroxylase gene and its polymorphic analysis as a candidate gene for congenital adrenal hyperplasia-like syndrome in Pomeranians
    K Takada
    Laboratory of Pathobiology, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Res Vet Sci 73:159-63
  6. Complications and failures in removable partial dentures: a clinical evaluation
    M Saito
    Removable Prosthodontics and Stomatognathic Rehabilitation, Department of Oral Functional Science, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan
    J Oral Rehabil 29:627-33
  7. Genomic organization, chromosomal localization, and promoter analysis of the mouse Mail gene
    T Shiina
    Department of Veterinary Physiology, Faculty of Agriculture, Iwate University, Ueda 3 18 8, Morioka 020 8550, Japan
    Immunogenetics 53:649-55
  8. No alteration in serum leptin levels during acute endotoxemia in sheep
    M Soliman
    Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    J Vet Med Sci 63:1143-5
  9. CDNA cloning of feline leptin and its mRNA expression in adipose tissue
    N Sasaki
    Department of Veterinary Science, Nippon Veterinary and Animal Science University, Musashino, Tokyo, Japan
    J Vet Med Sci 63:1115-20
  10. Comparison of cytokine-inducing activity in a lipoteichoic acid-related molecule isolated from a penicillin-killed group A Streptococcus and from untreated bacteria
    M Okamoto
    Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry, Japan
    Int Immunopharmacol 1:1957-68

Collaborators

Detail Information

Publications62

  1. Pharmacokinetics of zonisamide and drug interaction with phenobarbital in dogs
    K Orito
    Department of Pharmacology, School of Veterinary Medicine, Azabu University, Kanagawa, Japan
    J Vet Pharmacol Ther 31:259-64
    ..Caution may be necessary when zonisamide is given with phenobarbital and when antiepileptic therapy is changed from phenobarbital to zonisamide...
  2. Stress distribution of abutments and base displacement with precision attachment- and telescopic crown-retained removable partial dentures
    M Saito
    Removable Prosthodontics and Stomatognathic Rehabilitation, Department of Oral Functional Science, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan
    J Oral Rehabil 30:482-7
    ..The displacement of the denture base tended to be less when the denture was designed with a rigid connection for the retainer and with cross-arch stabilization...
  3. Genetic analyses of essential genes in cytological region 61D1-2 to 61F1-2 of Drosophila melanogaster
    M Saito
    Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Kawaguchi, Saitama 332 0012, Japan
    Mol Genet Genomics 268:446-54
    ..The present study extends our knowledge of the Drosophila gene set, by identifying most of the essential genes in the chromosomal region 61D1-2 to 61F1-2...
  4. LPS-stimulated human gingival fibroblasts inhibit the differentiation of monocytes into osteoclasts through the production of osteoprotegerin
    T Nagasawa
    Tokyo Medical and Dental University, Graduate School, Department of Hard Tissue Engineering Periodontology, Tokyo, Japan
    Clin Exp Immunol 130:338-44
    ..The present study suggests that LPS-stimulated HGFs inhibit monocyte differentiation into osteoclasts through the production of OPG...
  5. Cloning of canine 21-hydroxylase gene and its polymorphic analysis as a candidate gene for congenital adrenal hyperplasia-like syndrome in Pomeranians
    K Takada
    Laboratory of Pathobiology, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Res Vet Sci 73:159-63
    ..Our results indicate that the adrenal dysfunction in Pomeranians is not due to mutations of the 21-OH gene. This contrasts with the human form of CAH where 21-OH gene mutations are the major cause of the disease...
  6. Complications and failures in removable partial dentures: a clinical evaluation
    M Saito
    Removable Prosthodontics and Stomatognathic Rehabilitation, Department of Oral Functional Science, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan
    J Oral Rehabil 29:627-33
    ..Complication and failure rates of TDs were high at abutment teeth and low level at retainers. Complication and failure rates of ODs were high at retainers...
  7. Genomic organization, chromosomal localization, and promoter analysis of the mouse Mail gene
    T Shiina
    Department of Veterinary Physiology, Faculty of Agriculture, Iwate University, Ueda 3 18 8, Morioka 020 8550, Japan
    Immunogenetics 53:649-55
    ..This region is sufficient to drive high-level reporter gene expression in LPS-stimulated transfected cells...
  8. No alteration in serum leptin levels during acute endotoxemia in sheep
    M Soliman
    Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    J Vet Med Sci 63:1143-5
    ..These results indicate that serum leptin levels in sheep during acute endotoxemia are differentially regulated from those in rodent and human, and that leptin might not be involved in the endotoxin-induced anorexia in sheep...
  9. CDNA cloning of feline leptin and its mRNA expression in adipose tissue
    N Sasaki
    Department of Veterinary Science, Nippon Veterinary and Animal Science University, Musashino, Tokyo, Japan
    J Vet Med Sci 63:1115-20
    ..brain and skeletal muscle. These data show that feline leptin is highly homologous to leptins of other species, and expressed in adipose tissues in cats...
  10. Comparison of cytokine-inducing activity in a lipoteichoic acid-related molecule isolated from a penicillin-killed group A Streptococcus and from untreated bacteria
    M Okamoto
    Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry, Japan
    Int Immunopharmacol 1:1957-68
    ..It was also shown that penicillin treatment effectively enhances OK-PSA-induced anti-cancer immunity...
  11. Severe impairment of anti-cancer effect of lipoteichoic acid-related molecule isolated from a penicillin-killed Streptococcus pyogenes in toll-like receptor 4-deficient mice
    M Okamoto
    Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry, Japan
    Int Immunopharmacol 1:1789-95
    ..These findings strongly suggest that TLR4 signaling is involved in regulating OK-PSA-induced anti-cancer immunity...
  12. RIP 140 modulates transcription of the steroidogenic acute regulatory protein gene through interactions with both SF-1 and DAX-1
    T Sugawara
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Hokkaido 060 8638, Japan
    Endocrinology 142:3570-7
    ..We conclude that RIP 140 binds to the orphan nuclear receptor SF-1 and DAX-1 and modulates their actions on the human steroidogenic acute regulatory protein promoter...
  13. Anorectic effect of leptin is mediated by hypothalamic corticotropin-releasing hormone, but not by urocortin, in rats
    S Okamoto
    Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, 060-0818, Sapporo, Japan
    Neurosci Lett 307:179-82
    ..These results suggest that the anorectic effect of leptin is mediated by CRH, but not by urocortin, in the hypothalamus...
  14. Proinsulin C-peptide increases nitric oxide production by enhancing mitogen-activated protein-kinase-dependent transcription of endothelial nitric oxide synthase in aortic endothelial cells of Wistar rats
    T Kitamura
    Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Diabetologia 46:1698-705
    ..This could explain some actions of C-peptide on the vasculature, indicating a pivotal role for C-peptide in vascular homeostasis...
  15. A literature search on pharmacokinetic drug interactions of statins and analysis of how such interactions are reflected in package inserts in Japan
    M Saito
    Division of Medicinal Safety Science, National Institute of Health Sciences, Kamiyoga, Setagaya Ku, Tokyo, Japan
    J Clin Pharm Ther 30:21-37
    ..Including such information in the package insert will be an extremely valuable aid for health care providers...
  16. High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis
    M Saito
    Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Food Chem Toxicol 43:411-9
    ..Accordingly, 51 mmol HCA/kg diet (389 mg HCA/kg BW/d) was deemed to be the no observed adverse effect level (NOAEL)...
  17. Role of uncoupling protein 1 in the anti-obesity effect of beta3-adrenergic agonist in the dog
    A Omachi
    Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Res Vet Sci 85:214-9
    ..It was suggested that UCP1-dependent energy expenditure in adipose tissue contributes to the anti-obesity effect of beta3-adrenoceptor agonist in dogs...
  18. No pharmacokinetic interactions between mycophenolic acid and tacrolimus in renal transplant recipients
    H Kagaya
    Department of Pharmacy, Akita University Hospital, Akita, Japan
    J Clin Pharm Ther 33:193-201
    ..Consequently, MPA and tacrolimus can be safely combined; however, it is necessary to monitor the plasma concentrations of each immunosuppressive agent to minimize acute rejection...
  19. Hypercalcemia in childhood acute lymphoblastic leukemia: frequent implication of parathyroid hormone-related peptide and E2A-HLF from translocation 17;19
    T Inukai
    Department of Pediatrics, University of Yamanashi, School of Medicine, Yamanashi, Japan
    Leukemia 21:288-96
    ..Excluding the t(17;19)-ALL patients, the final outcome of ALL accompanied by hypercalcemia was similar to that of all childhood ALL patients, indicating that the development of hypercalcemia itself is not a poor prognostic factor...
  20. Beta3-adrenoceptor agonist AJ-9677 reduces body fat in obese beagles
    A Omachi
    Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Res Vet Sci 83:5-11
    ..The plasma levels of leptin and adiponectin were decreased and increased, respectively, after the AJ treatment, reflecting the reduction of adiposity. It was concluded that AJ-9677 is useful for the treatment of obesity in the dog...
  21. Establishment of immortalized dental follicle cells for generating periodontal ligament in vivo
    T Yokoi
    Department of Medicine, Division of Operative Dentistry and Endodontics, Kanagawa Dental College, Yokosuka, Kanagawa, Japan
    Cell Tissue Res 327:301-11
    ..Our findings suggest that MDF( E6-EGFP ) cells can act as PDL progenitors, and that these cells may be a useful research tool for studying PDL formation and for developing regeneration therapies...
  22. Fulminant type 1 diabetes mellitus observed in insulin receptor substrate 2 deficient mice
    T Arai
    Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino, Tokyo, 180 8602, Japan
    Clin Exp Med 8:93-9
    ..IRS2-deficient mice may be a useful animal model for studying the degradation mechanism of pancreatic beta cells in the process of development of fulminant type 1 DM...
  23. Functional roles of 5-hydroxytryptamine 3/4 receptors in neurons of rat dorsal motor nucleus of the vagus
    E Fukushi
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido 1757, Kanazawa, Ishikari-Tobetsu, Hokkaido 061-0293, Japan
    Neuroscience 141:675-85
    ....
  24. Effect of ovariectomy and ad libitum feeding on body composition, thyroid status, ghrelin and leptin plasma concentrations in female dogs
    I Jeusette
    Animal Nutrition Unit, Faculty of Veterinary Medicine, University of Liège, Belgium
    J Anim Physiol Anim Nutr (Berl) 90:12-8
    ..However, the significant weight gain shows that this goal was not achieved...
  25. Canine adiponectin: cDNA structure, mRNA expression in adipose tissues and reduced plasma levels in obesity
    K Ishioka
    Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Res Vet Sci 80:127-32
    ..These results are compatible with those reported in other species, and suggest that adiponectin is an index of adiposity and a target molecule for studies on diseases associated with obesity in dogs...
  26. Proinsulin C-peptide activates vagus efferent output in rats
    K Kimura
    Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Peptides 26:2547-53
    ..This could explain, at least in part, the ameliorating effects of C-peptide on impaired cardiac autonomic nerve functions in patients with type 1 diabetes...
  27. UCP1 deficiency increases susceptibility to diet-induced obesity with age
    Y Kontani
    Department of Aging Intervention, National Institute for Longevity Sciences, 36-3 Gengo, Obu 474-8522, Japan
    Aging Cell 4:147-55
    ....
  28. Diurnal variations of serum leptin in dogs: effects of fasting and re-feeding
    K Ishioka
    Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Vet J 169:85-90
    ..The results indicate that serum leptin concentrations change diurnally in association with feeding-fasting cycles in the dog, partially due to changes in insulin secretion...
  29. Serine acetyltransferase involved in cysteine biosynthesis from spinach: molecular cloning, characterization and expression analysis of cDNA encoding a plastidic isoform
    M Noji
    Department of Molecular Biology and Biotechnology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 263 8522 Japan
    Plant Cell Physiol 42:627-34
    ..The result from in vitro translation analysis suggests that this cDNA may encode both plastidic and cytosolic SATases...
  30. Characterization of three members of murine alpha1,2-fucosyltransferases: change in the expression of the Se gene in the intestine of mice after administration of microbes
    B Lin
    Department of Biochemistry and Molecular Biology, Graduate School of Medicine, University of Tokyo, Japan
    Arch Biochem Biophys 388:207-15
    ..The administration of microbes into germ-free mice resulted in a rapid increase of the MFUT-II gene (Se gene) for the synthesis of fucosyl GA1 in the intestine...
  31. Mutated human beta3-adrenergic receptor (Trp64Arg) lowers the response to beta3-adrenergic agonists in transfected 3T3-L1 preadipocytes
    K Kimura
    Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Horm Metab Res 32:91-6
    ....
  32. Canine leptin: cDNA cloning, expression and activity of recombinant protein
    M Iwase
    Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, 060 0818, Japan
    Res Vet Sci 68:109-14
    ..The data reported herein will be helpful for further studies of leptin of the dog in health and disease...
  33. Presence of telomeric G-strand tails in the telomerase catalytic subunit TERT knockout mice
    X Yuan
    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori ku, Yokohama, 226 8501, Japan
    Genes Cells 4:563-72
    ..The presence of the telomeric G-strand tails in mTERT -/- mice suggests that these telomeric 5'-overhangs are produced by telomerase-independent mechanisms, as has been proposed for yeast and human...
  34. Expression cloning and functional characterization of human cDNA for ganglioside GM3 synthase
    A Ishii
    Virology and Glycobiology Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    J Biol Chem 273:31652-5
    ..4-kilobase transcript of the gene was found in a tissue-specific manner, with predominant expression in brain, skeletal muscle, and testis, and very low expression in liver...
  35. TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family
    J Nakayama
    Department of Life Science, Tokyo Institute of Technology, Yokohama, Japan
    Cell 88:875-84
    ..A pulse-chase experiment showed that p240 is modified to p230 in vivo. p230 was the dominant form in telomerase-positive cells, suggesting that modification of the TLP1 protein may regulate telomerase activity in vivo...
  36. Molecular cloning and mRNA expression of the bovine insulin-responsive glucose transporter (GLUT4)
    H Abe
    Department of Animal Nutrition, National Institute of Animal Industry, Tsukuba, Japan
    J Anim Sci 75:182-8
    ..Such a distribution is essentially the same as in humans and rodents, suggesting that GLUT4 is an insulin-responsive glucose transporter in cattle...
  37. The retinoblastoma protein binds to a family of E2F transcription factors
    J A Lees
    Massachusetts General Hospital Cancer Center, Charlestown 02129
    Mol Cell Biol 13:7813-25
    ..These observations suggest that the E2F activities described previously result from the combined action of a family of proteins...
  38. Reduced content and preserved translocation of glucose transporter (GLUT 4) in white adipose tissue of obese mice
    U F Machado
    Department of Physiology and Biophysics, University of São Paulo, Brazil
    Physiol Behav 55:621-5
    ..We conclude that WAT of insulin-resistant obese AuTG- and MSG-treated mice has a decreased GLUT 4, but not GLUT 1, content, and the in vivo insulin-stimulated GLUT 4 translocation is preserved...
  39. Molecular cloning and functional expression of a cDNA encoding the human V1b vasopressin receptor
    T Sugimoto
    Molecular Medicine Research Laboratories, Yamanouchi Institute for Drug Discovery Research, Ibaraki, Japan
    J Biol Chem 269:27088-92
    ..Northern blot analysis revealed that the receptor expression is restricted to the pituitary. These data clearly indicate that the cloned cDNA encodes the V1b receptor...
  40. Molecular cloning and characterization of rat V1b vasopressin receptor: evidence for its expression in extra-pituitary tissues
    M Saito
    Molecular Medicine Research Laboratory, Yamanouchi Pharmaceutical Co, Ltd, Ibaraki, Japan
    Biochem Biophys Res Commun 212:751-7
    ..This finding raises the possibility that V1b may play a role in regulating cell functions of these tissues...
  41. Molecular cloning and expression of an IL-6 signal transducer, gp130
    M Hibi
    Division of Immunology, Osaka University, Japan
    Cell 63:1149-57
    ..A cloned gp130 could associate with a complex of IL-6 and soluble IL-6-R and transduce the growth signal when expressed in a murine IL-3-dependent cell line...
  42. Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis
    T Sugita
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    J Exp Med 171:2001-9
    ..Since IL-6 functions as a potent growth factor for murine plasmacytomas, over-expression of abnormal IL-6-R may function as a positive selection element for the development of certain plasmacytomas...
  43. Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo
    M Saito
    Division of Immunology, Institute for Molecular and Cellular Biology, Osaka University, Japan
    J Immunol 148:4066-71
    ..Administration of IL-6 in mouse caused up-regulation of the gp130 mRNA levels in several tissues. Both gp130 and IL-6R mRNA in liver were up-regulated in vivo by IL-6...
  44. Sp1 and SF-1 interact and cooperate in the regulation of human steroidogenic acute regulatory protein gene expression
    T Sugawara
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Japan
    Endocrinology 141:2895-903
    ..In conclusion, our data indicate that Spl and SF-1 physically interact and cooperate in the regulation of human StAR promoter activity...
  45. Absence of p51 alteration in human ovarian cancer
    H Shinozaki
    Department of Obstetrics and Gynecology, The Jikei University School of Medicine, Minato-ku, Tokyo 105-8461, Japan
    Int J Oncol 18:549-52
    ..These results indicated that p51 gene expression was silent in normal ovarian tissues and primary ovarian cancers, and that mutation of the p51 gene does not play a major role in the development of ovarian cancer...
  46. Proinsulin C-peptide rapidly stimulates mitogen-activated protein kinases in Swiss 3T3 fibroblasts: requirement of protein kinase C, phosphoinositide 3-kinase and pertussis toxin-sensitive G-protein
    T Kitamura
    Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan
    Biochem J 355:123-9
    ..These results suggest that C-peptide activates MAPK through a putative G(i)/G(o)-linked receptor for C-peptide and through PI-3K-dependent and PKC-dependent pathways...
  47. Measurement of the back fat layer in beagles for estimation of obesity using two-dimensional ultrasonography
    T Morooka
    Veterinary Internal Medicine 2, Rakuno Gakuen University, Ebetsu, Japan
    J Small Anim Pract 42:56-9
    ..The depth and area of the back fat layer at these locations were closely related to the degree of obesity...
  48. Involvement of upstream open reading frames in regulation of rat V(1b) vasopressin receptor expression
    A Nomura
    First Department of Internal Medicine, Nagoya University School of Medicine and Hospital, Nagoya 466-8560, Japan
    Am J Physiol Endocrinol Metab 280:E780-7
    ..Whether the uORF-mediated regulation of V(1b) expression is functionally linked to any intracellular and/or extracellular factor(s) awaits further research...
  49. Beta 3-adrenergic agonist up-regulates uncoupling proteins 2 and 3 in skeletal muscle of the mouse
    Y Nakamura
    Department of Biomedical Sciences, School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    J Vet Med Sci 63:309-14
    ..It was also suggested that anti-obesity effect of beta3-AR agonists is attributable to increased thermogenesis not only by UCP1 but also by UCP2 and UCP3...
  50. MAIL, a novel nuclear I kappa B protein that potentiates LPS-induced IL-6 production
    H Kitamura
    Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    FEBS Lett 485:53-6
    ..These findings indicate that MAIL is one of the nuclear I kappa B proteins and an activator of IL-6 production...
  51. Up-regulation of uncoupling proteins by beta-adrenergic stimulation in L6 myotubes
    I Nagase
    Department of Biomedical Sciences, Laboratory of Biochemistry, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan
    FEBS Lett 494:175-80
    ..These results suggested that catecholamines up-regulate UCP2 and UCP3 expression through direct action on the beta2-AR in skeletal muscle...
  52. Characterization of a rainbow trout matrix metalloproteinase capable of degrading type I collagen
    M Saito
    Laboratory of Food Science, Kagawa Nutrition University, Komagome, Toshima, Tokyo, Japan
    Eur J Biochem 267:6943-50
    ..These results have revealed that the cDNA encodes a unique MMP-13 of rainbow trout. This is the first report of cDNA coding for fish MMP capable of degrading type I collagen...
  53. GDP-fucose: beta-galactoside alpha1,2-fucosyltransferase, MFUT-II, and not MFUT-I or -III, is induced in a restricted region of the digestive tract of germ-free mice by host-microbe interactions and cycloheximide
    B Lin
    Department of Biochemistry and Molecular Biology, University of Tokyo, Hongo, Tokyo, Japan
    Biochim Biophys Acta 1487:275-85
    ..At 24 h after the administration of cycloheximide, FGA1 was preferentially produced in the upper half of the duodenal microvilli...
  54. Abundant expression of uncoupling protein-2 in the small intestine: up-regulation by dietary fish oil and fibrates
    T Murase
    Biological Science Laboratories, Kao Corporation, Tochigi, Japan
    Biochim Biophys Acta 1530:15-22
    ..These results indicated that intestinal UCP-2 is up-regulated through direct activation of PPARalpha by dietary fatty acids...
  55. Blood tritium level as an estimate of soft tissue dose
    M Saito
    Research Reactor Institute of Kyoto University, Kumatori cho, Sennan gun, Osaka, Japan
    Radiat Prot Dosimetry 105:417-20
    ..The accumulated dose to soft tissues after oral administration tended to be lower than that for intraperitoneal injection...
  56. Establishment and characterization of a steroidogenic human granulosa-like tumor cell line, KGN, that expresses functional follicle-stimulating hormone receptor
    Y Nishi
    Department of Medicine and Bioregulatory Science (Third Department of Internal Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    Endocrinology 142:437-45
    ..Based on these findings, this cell line is considered to be a very useful model for understanding the regulation of steroidogenesis, cell growth, and apoptosis in human granulosa cells...
  57. Scanning of five chromosomes for alcohol consumption loci
    C Vadasz
    Laboratory of Neurobehavior Genetics, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, 10962, Orangeburg, NY, USA
    Alcohol 22:25-34
    ..1) and opioid receptor kappa 3 (chr. 2), respectively. The results of this gene-mapping study suggest that genetic polymorphisms in kappa opioid receptors may contribute to genetic predisposition to voluntary alcohol-drinking behavior...
  58. Neutrophil elastase inhibitor ameliorates reperfusion injury in a canine model of lung transplantation
    T Aoki
    Department of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
    Eur Surg Res 37:274-80
    ..CONCLUSION: Neutrophil elastase inhibitor ONO-5046 Na may be useful in ameliorating lung reperfusion injury after transplantation...
  59. gp130, the cytokine common signal-transducer of interleukin-6 cytokine family, is downregulated in T cells in vivo by interleukin-6
    X J Wang
    Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    Blood 91:3308-14
    ..These results suggest that the expression of gp130 in splenic T cells could be downregulated by the IL-6 stimulation under physiological or pathological circumstances...
  60. A neurological disease caused by an expanded CAG trinucleotide repeat in the TATA-binding protein gene: a new polyglutamine disease?
    R Koide
    Department of Neurology, Niigata University, Japan
    Hum Mol Genet 8:2047-53
    ..The present study provides new insights into sporadic-onset trinucleotide repeat diseases that involve de novo CAG repeat expansion...
  61. Neuropathological analysis in spinal muscular atrophy type II
    S Araki
    Department of Neuropediatrics, Tokyo Metropolitan Neurological Hospital, 2 6 1 Musashi dai, Fuchu shi, 183 0042, Tokyo, Japan
    Acta Neuropathol 106:441-8
    ..These data suggest that oxidative stress and, to a lesser extent, apoptotic cell death, but not disturbed neurofilament metabolism or excitotoxicity, may be involved in neurodegeneration in SMA type II...
  62. Plasma leptin concentration in dogs: effects of body condition score, age, gender and breeds
    K Ishioka
    Department of Veterinary Nursing, School of Veterinary Nursing and Technology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, Kyonan cho, Musashino shi, Tokyo 180 8602, Japan
    Res Vet Sci 82:11-5
    ..We conclude that plasma leptin is a reliable marker of adiposity in dogs regardless of age, gender and breed variations, and thereby useful as a blood biochemistry test for health examinations and treatment of obesity...