Motohiko Okano

Summary

Affiliation: Hokkaido Institute of Public Health
Country: Japan

Publications

  1. ncbi request reprint Proposed guidelines for diagnosing chronic active Epstein-Barr virus infection
    Motohiko Okano
    Department of Pediatrics, Hokkaido University Hospital, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Am J Hematol 80:64-9. 2005
  2. doi request reprint Acute or chronic life-threatening diseases associated with Epstein-Barr virus infection
    Motohiko Okano
    Center for Infectious Diseases Control, Hokkaido Institute of Public Health, Sapporo, Japan
    Am J Med Sci 343:483-9. 2012
  3. ncbi request reprint Advanced therapeutic and prophylactic strategies for Epstein-Barr virus infection in immunocompromised patients
    Motohiko Okano
    Department of Microbiology, Center for Infectious Diseases Control, Hokkaido Institute of Public Health, Kita ku, Sapporo, Japan
    Expert Rev Anti Infect Ther 5:403-13. 2007
  4. doi request reprint Usefulness of the rapid determination system of viral genome sequences in human stool specimens
    Masahiro Miyoshi
    Center for Infectious Diseases Control, Hokkaido Institute of Public Health, North 19 West 12, Kita ku, Sapporo 060 0819, Japan
    J Virol Methods 179:256-60. 2012
  5. ncbi request reprint Prognostic factors for chronic active Epstein-Barr virus infection
    Hiroshi Kimura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Infect Dis 187:527-33. 2003
  6. doi request reprint Genomic characterization of echovirus 6 causing aseptic meningitis in Hokkaido, Japan: a novel cluster in the nonstructural protein coding region of human enterovirus B
    Masahiro Miyoshi
    Center for Infectious Diseases Control, Hokkaido Institute of Public Health, North 19 West 12, Kita ku, Sapporo, 060 0819, Japan
    Arch Virol 158:775-84. 2013
  7. doi request reprint Sensitive and rapid detection of norovirus using duplex TaqMan reverse transcription-polymerase chain reaction
    Setsuko Ishida
    Division of Enteric Virology, Department of Microbiology, Hokkaido Institute of Public Health, Sapporo, Japan
    J Med Virol 80:913-20. 2008
  8. doi request reprint A 5-year-old boy with unicentric Castleman disease affecting the mesentery: utility of serum IL-6 level and (18)F-FDG PET for diagnosis
    Nariaki Toita
    Department of Pediatrics, Graduate School of Medicine, Japan
    J Pediatr Hematol Oncol 31:693-5. 2009
  9. ncbi request reprint Epstein-Barr virus-associated B-cell lymphoma in a patient with DNA ligase IV (LIG4) syndrome
    Nariaki Toita
    Department of Pediatrics, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Am J Med Genet A 143:742-5. 2007
  10. ncbi request reprint Epidemiological and molecular studies of measles at different clusters in hokkaido district, Japan, 2007
    Hideki Nagano
    Center for Infectious Diseases Control, Hokkaido Institute of Public Health, Sapporo 060 0819, Japan
    Jpn J Infect Dis 62:209-11. 2009

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Proposed guidelines for diagnosing chronic active Epstein-Barr virus infection
    Motohiko Okano
    Department of Pediatrics, Hokkaido University Hospital, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Am J Hematol 80:64-9. 2005
    ..Guidelines, derived mainly from the current literature and recent experiences with CAEBV in Japan, for diagnosing CAEBV are proposed to clarify this enigmatic disease...
  2. doi request reprint Acute or chronic life-threatening diseases associated with Epstein-Barr virus infection
    Motohiko Okano
    Center for Infectious Diseases Control, Hokkaido Institute of Public Health, Sapporo, Japan
    Am J Med Sci 343:483-9. 2012
    ..This review will focus on the historical, pathogenetic, diagnostic, therapeutic and prophylactic issues of EBV-associated life-threatening diseases...
  3. ncbi request reprint Advanced therapeutic and prophylactic strategies for Epstein-Barr virus infection in immunocompromised patients
    Motohiko Okano
    Department of Microbiology, Center for Infectious Diseases Control, Hokkaido Institute of Public Health, Kita ku, Sapporo, Japan
    Expert Rev Anti Infect Ther 5:403-13. 2007
    ..This review will discuss EBV biology and immune events that occur in both immunocompetent and immunocompromised individuals and introduce the novel prophylactic and therapeutic strategies for EBV-associated life-threatening diseases...
  4. doi request reprint Usefulness of the rapid determination system of viral genome sequences in human stool specimens
    Masahiro Miyoshi
    Center for Infectious Diseases Control, Hokkaido Institute of Public Health, North 19 West 12, Kita ku, Sapporo 060 0819, Japan
    J Virol Methods 179:256-60. 2012
    ..2×10(6) and 9.8×10(11)/g stool. These results suggest that the RDV method has potential for detecting viral genomes in stool specimens. The procedure without a step of nuclease treatment appears to be sensitive...
  5. ncbi request reprint Prognostic factors for chronic active Epstein-Barr virus infection
    Hiroshi Kimura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Infect Dis 187:527-33. 2003
    ..59 vs. 0.87; P<.009). Patients with CAEBV with late onset of disease, thrombocytopenia, and T cell infection had significantly poorer outcomes...
  6. doi request reprint Genomic characterization of echovirus 6 causing aseptic meningitis in Hokkaido, Japan: a novel cluster in the nonstructural protein coding region of human enterovirus B
    Masahiro Miyoshi
    Center for Infectious Diseases Control, Hokkaido Institute of Public Health, North 19 West 12, Kita ku, Sapporo, 060 0819, Japan
    Arch Virol 158:775-84. 2013
    ..These results suggest that the incidence of AM in Japan in 2011 was caused by at least two lineages of E6 strains, and a lineage of the 3CD gene was interspersed among different serotypic strains isolated in Western Pacific countries...
  7. doi request reprint Sensitive and rapid detection of norovirus using duplex TaqMan reverse transcription-polymerase chain reaction
    Setsuko Ishida
    Division of Enteric Virology, Department of Microbiology, Hokkaido Institute of Public Health, Sapporo, Japan
    J Med Virol 80:913-20. 2008
    ..These results suggest the practical application of this duplex TaqMan RT-PCR is useful for the detection of NV in clinical specimens...
  8. doi request reprint A 5-year-old boy with unicentric Castleman disease affecting the mesentery: utility of serum IL-6 level and (18)F-FDG PET for diagnosis
    Nariaki Toita
    Department of Pediatrics, Graduate School of Medicine, Japan
    J Pediatr Hematol Oncol 31:693-5. 2009
    ..Our case also supported an important role of interleukin-6 in the pathophysiology of plasma cell CD...
  9. ncbi request reprint Epstein-Barr virus-associated B-cell lymphoma in a patient with DNA ligase IV (LIG4) syndrome
    Nariaki Toita
    Department of Pediatrics, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Am J Med Genet A 143:742-5. 2007
    ..We report here on a case of LIG4 syndrome complicated with distinct EBV-associated B-cell lymphoma...
  10. ncbi request reprint Epidemiological and molecular studies of measles at different clusters in hokkaido district, Japan, 2007
    Hideki Nagano
    Center for Infectious Diseases Control, Hokkaido Institute of Public Health, Sapporo 060 0819, Japan
    Jpn J Infect Dis 62:209-11. 2009
    ..The occurrence pattern of measles patients and molecular epidemiology indicated that the measles virus that spread in Hokkaido district might not be indigenous...
  11. ncbi request reprint The evolving therapeutic approaches for Epstein-Barr virus infection in immunocompetent and immunocompromised individuals
    Motohiko Okano
    Department of Pediatrics, Hokkaido University Hospital, Hokkaido University Graduate School of Medicine, North 14 West 5, Kita ku, Sapporo 060 8648, Japan
    Curr Drug Targets Immune Endocr Metabol Disord 3:137-42. 2003
    ..This concise review focuses on recent understanding of the pathogenetic mechanisms in various EBV-associated diseases in immunocompetent and immunocompromised individuals, and discusses potent therapeutic approaches in each condition...
  12. ncbi request reprint Overview and problematic standpoints of severe chronic active Epstein-Barr virus infection syndrome
    Motohiko Okano
    Department of Pediatrics, Hokkaido University School of Medicine, North 15 West 7, Kita ku, Sapporo 060 8638, Japan
    Crit Rev Oncol Hematol 44:273-82. 2002
    ..This review is an overview of SCAEBV with respect to its; history, diagnosis, pathogenesis, therapeutic approaches, and ideas on how to further recognize this enigmatic disease...
  13. ncbi request reprint A cluster of hepatitis E virus infection in Hokkaido, Japan
    Setsuko Ishida
    Hokkaido Institute of Public Health, Sapporo 060 0819, Japan
    Jpn J Infect Dis 59:135-6. 2006