Hiroshi Okamoto

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. doi request reprint Minimal dose for effective clinical outcome and predictive factors for responsiveness to carvedilol: Japanese chronic heart failure (J-CHF) study
    Hiroshi Okamoto
    Department of Cardiovascular Medicine, National Hospital Organization, Hokkaido Medical Center, Sapporo, Japan
    Int J Cardiol 164:238-44. 2013
  2. ncbi request reprint Osteopontin and cardiovascular system
    Hiroshi Okamoto
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita ku, Kita 14, Nishi 5, Sapporo 060 8638, Japan
    Mol Cell Biochem 300:1-7. 2007
  3. ncbi request reprint Evaluation of effects of polymorphism for metabolic enzymes on pharmacokinetics of carvedilol by population pharmacokinetic analysis
    Yoh Takekuma
    Laboratory of Pharmcotherapeutic Information, Department of Biopharmaceutical Sciences and Pharmacy, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 jo, Nishi 6 chome, Kita ku, Sapporo 060 0812, Japan
    Biol Pharm Bull 30:537-42. 2007
  4. ncbi request reprint Contribution of polymorphisms in UDP-glucuronosyltransferase and CYP2D6 to the individual variation in disposition of carvedilol
    Yoh Takekuma
    Department of Clinical Pharmaceutics and Therapeutics, Graduate School of Pharmaceutical Science, Hokkaido University, Sapporo, Japan
    J Pharm Pharm Sci 9:101-12. 2006
  5. doi request reprint Matricellular proteins: new molecular targets to prevent heart failure
    Hiroshi Okamoto
    Department of Cardiovascular Medicine, Hokkaido Medical Center, Sapporo, Japan okamotoh med hokudai ac jp
    Cardiovasc Ther 30:e198-209. 2012
  6. ncbi request reprint Decreased myocardial beta-adrenergic receptor density in relation to increased sympathetic tone in patients with nonischemic cardiomyopathy
    Takahiro Tsukamoto
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Nucl Med 48:1777-82. 2007
  7. ncbi request reprint [Future perspectives of beta-blockers in chronic heart failure]
    Hiroshi Okamoto
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
    Nihon Rinsho 64:921-6. 2006
  8. ncbi request reprint [The epidemiology of heart failure in Japan]
    Hiroshi Okamoto
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
    Nihon Rinsho 61:709-14. 2003
  9. doi request reprint Pravastatin attenuates left ventricular remodeling and diastolic dysfunction in angiotensin II-induced hypertensive mice
    Zhujie Xu
    Department of Cardiovascular Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    J Cardiovasc Pharmacol 51:62-70. 2008
  10. ncbi request reprint Osteopontin deficiency attenuates atherosclerosis in female apolipoprotein E-deficient mice
    Yutaka Matsui
    Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 0815, Japan
    Arterioscler Thromb Vasc Biol 23:1029-34. 2003

Collaborators

Detail Information

Publications26

  1. doi request reprint Minimal dose for effective clinical outcome and predictive factors for responsiveness to carvedilol: Japanese chronic heart failure (J-CHF) study
    Hiroshi Okamoto
    Department of Cardiovascular Medicine, National Hospital Organization, Hokkaido Medical Center, Sapporo, Japan
    Int J Cardiol 164:238-44. 2013
    ..We sought to determine the minimal dose related to survival benefits by comparing the efficacy and safety of three doses of carvedilol and the best predictive parameter for effective outcomes in Japanese patients with CHF...
  2. ncbi request reprint Osteopontin and cardiovascular system
    Hiroshi Okamoto
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita ku, Kita 14, Nishi 5, Sapporo 060 8638, Japan
    Mol Cell Biochem 300:1-7. 2007
    ..6) While the significance of OPN as an immune system molecule is still unclear in detail, the significance of OPN in the regenerative immune system has begun to be determined...
  3. ncbi request reprint Evaluation of effects of polymorphism for metabolic enzymes on pharmacokinetics of carvedilol by population pharmacokinetic analysis
    Yoh Takekuma
    Laboratory of Pharmcotherapeutic Information, Department of Biopharmaceutical Sciences and Pharmacy, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 jo, Nishi 6 chome, Kita ku, Sapporo 060 0812, Japan
    Biol Pharm Bull 30:537-42. 2007
    ..It was estimated that UGT2B7*3 decreased the clearance of carvedilol by 37%, but UGT2B7*2 did not show any effect. Clearance in the patients who have intermediate activity of CYP2D6 was decreased by 39%...
  4. ncbi request reprint Contribution of polymorphisms in UDP-glucuronosyltransferase and CYP2D6 to the individual variation in disposition of carvedilol
    Yoh Takekuma
    Department of Clinical Pharmaceutics and Therapeutics, Graduate School of Pharmaceutical Science, Hokkaido University, Sapporo, Japan
    J Pharm Pharm Sci 9:101-12. 2006
    ....
  5. doi request reprint Matricellular proteins: new molecular targets to prevent heart failure
    Hiroshi Okamoto
    Department of Cardiovascular Medicine, Hokkaido Medical Center, Sapporo, Japan okamotoh med hokudai ac jp
    Cardiovasc Ther 30:e198-209. 2012
    ..This review provides an overview of the role of matricellular proteins such as OPN and TN-C in cardiac function and remodeling, as determined by both in basic and in clinical studies...
  6. ncbi request reprint Decreased myocardial beta-adrenergic receptor density in relation to increased sympathetic tone in patients with nonischemic cardiomyopathy
    Takahiro Tsukamoto
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Nucl Med 48:1777-82. 2007
    ....
  7. ncbi request reprint [Future perspectives of beta-blockers in chronic heart failure]
    Hiroshi Okamoto
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
    Nihon Rinsho 64:921-6. 2006
    ..This trial may serve as a tailored approach for Japanese physicians in the clinical management of heart failure...
  8. ncbi request reprint [The epidemiology of heart failure in Japan]
    Hiroshi Okamoto
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
    Nihon Rinsho 61:709-14. 2003
    ..Patients were older and less severely affected, partly explaining the improvement in survival. In the subgroups treated with ACE inhibitors and beta blockers, calculated ten-year survival rate reached over 90%...
  9. doi request reprint Pravastatin attenuates left ventricular remodeling and diastolic dysfunction in angiotensin II-induced hypertensive mice
    Zhujie Xu
    Department of Cardiovascular Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    J Cardiovasc Pharmacol 51:62-70. 2008
    ..However, the exact mechanisms of statins possibly explaining the decreased cardiovascular morbidity and mortality in patients with DHF have not been elucidated...
  10. ncbi request reprint Osteopontin deficiency attenuates atherosclerosis in female apolipoprotein E-deficient mice
    Yutaka Matsui
    Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 0815, Japan
    Arterioscler Thromb Vasc Biol 23:1029-34. 2003
    ..However, it is not known whether the elevated OPN expression is a cause or result of atherosclerosis...
  11. ncbi request reprint Long-term combined therapy with an angiotensin type I receptor blocker and an angiotensin converting enzyme inhibitor prolongs survival in dilated cardiomyopathy
    Toshihiro Shimizu
    Department of Cardiovascular Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Jpn Heart J 43:531-43. 2002
    ..05) as well as group C (P<0.001). It is concluded that combined therapy improved cardiac function and survival compared to placebo or enalapril monotherapy...
  12. ncbi request reprint Development of atherosclerosis in osteopontin transgenic mice
    Satoru Chiba
    Department of Cardiovascular Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Heart Vessels 16:111-7. 2002
    ..Thus, these results suggest that OPN is atherogenic and that macrophages expressing OPN can be easily activated and thus promote atheromatous lesions if a high fat diet is consumed...
  13. ncbi request reprint Rationale and design of a randomized trial to assess the effects of beta-blocker in diastolic heart failure; Japanese Diastolic Heart Failure Study (J-DHF)
    Masatsugu Hori
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Japan
    J Card Fail 11:542-7. 2005
    ....
  14. pmc No positive association between adrenergic receptor variants of alpha2cDel322-325, beta1Ser49, beta1Arg389 and the risk for heart failure in the Japanese population
    Shinpei Nonen
    Department of Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    Br J Clin Pharmacol 60:414-7. 2005
    ..We investigated the correlation of adrenergic receptor polymorphisms, alpha(2c)Del322-325, beta(1)Ser49Gly and beta(1)Arg389Gly, with the risk of heart failure in the Japanese population...
  15. ncbi request reprint [J-CHF Study]
    Hiroshi Okamoto
    Department of Cardiovascular Medicine, Hokkaido University
    Nihon Rinsho 65:537-42. 2007
  16. pmc Protective effect of A at position - 168 in the type III promoter of the MHCIITA gene in systemic lupus erythematosus
    Hiroshi Okamoto
    Ann Rheum Dis 66:1263-4. 2007
  17. ncbi request reprint [Genetic polymorphism in heart failure]
    Hiroshi Okamoto
    Department of Cardiovascular Medicine, Hokkaido University
    Nihon Rinsho 65:278-84. 2007
  18. doi request reprint Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population
    Shu Kobayashi
    Tokyo Women s Medical University, Tokyo, Japan
    Arthritis Rheum 58:1940-6. 2008
    ..The present study was undertaken to investigate the effect of STAT4 on susceptibility to RA and SLE in the Japanese...
  19. ncbi request reprint [Epidemiology of heart failure in Japan]
    Hiroshi Okamoto
    Department of Cardiovascular Medicine, Hokkaido University
    Nihon Rinsho 65:49-54. 2007
  20. ncbi request reprint Higher serum tenascin-C levels reflect the severity of heart failure, left ventricular dysfunction and remodeling in patients with dilated cardiomyopathy
    Fumio Terasaki
    Department of Internal Medicine III, Osaka Medical College, Takatsuki, Japan
    Circ J 71:327-30. 2007
    ..Therefore, the expression of TN-C might be useful for detecting the clinical characteristics of, and ventricular remodeling in, dilated cardiomyopathy (DCM)...
  21. pmc MHC2TA is associated with rheumatoid arthritis in Japanese patients
    Noriko Iikuni
    Ann Rheum Dis 66:274-5. 2007
  22. ncbi request reprint Computational algorithms and neuronal network models underlying decision processes
    Yutaka Sakai
    Department of Intelligent Information Systems, Tamagawa University, Tamagawa Gakeun 6 1 1, Machida, Tokyo, Japan
    Neural Netw 19:1091-105. 2006
    ..In this article, we review results of recent experimental and theoretical studies of neuronal substrates and computational algorithms for decision processes...
  23. ncbi request reprint S-(2-(acylamino)phenyl) 2,2-dimethylpropanethioates as CETP inhibitors
    Kimiya Maeda
    Central Pharmaceutical Research Institute, JT Inc, 1 1 Murasaki cho, Takatsuki, Osaka 569 1125, Japan
    Bioorg Med Chem Lett 14:2589-91. 2004
    ..The most potent compound showed 50% inhibition of CETP activity in human plasma at a concentration of 2 microM...
  24. ncbi request reprint Rationale for the use of combination angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker therapy in heart failure
    Yoshio Yasumura
    Division of Cardiology, Department of Medicine, University of Tsukuba, Japan
    Circ J 68:361-6. 2004
    ....
  25. ncbi request reprint REG I as a marker for human pancreatic acinoductular cells
    Ekmel Tezel
    Department of Surgery II, Nagoya University, School of Medicine Nagoya, Japan
    Hepatogastroenterology 51:91-6. 2004
    ..To date, however, there has been no study which examined the expression of REG I along with other differentiation markers in patients with chronic pancreatitis...
  26. ncbi request reprint Effect of HDL, from Japanese white rabbit administered a new cholesteryl ester transfer protein inhibitor JTT-705, on cholesteryl ester accumulation induced by acetylated low density lipoprotein in J774 macrophage
    Junji Kobayashi
    Second Department of Internal Medicine, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Atherosclerosis 162:131-5. 2002
    ....