F Okada

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. ncbi request reprint Inflammation and free radicals in tumor development and progression
    Futoshi Okada
    Division of Cancer Pathobiology, Research Section of Pathophysiology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 0815, Japan
    Redox Rep 7:357-68. 2002
  2. ncbi request reprint Conversion of human colonic adenoma cells to adenocarcinoma cells through inflammation in nude mice
    F Okada
    Division of Cancer Pathobiology, Research Section of Pathophysiology, Institute for Genetic Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    Lab Invest 80:1617-28. 2000
  3. ncbi request reprint Increased oxidative DNA damage in mammary tumor cells by continuous epidermal growth factor stimulation
    J Hamada
    Division of Cancer Related Genes, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    J Natl Cancer Inst 93:214-9. 2001
  4. pmc Inflammatory cell-mediated tumour progression and minisatellite mutation correlate with the decrease of antioxidative enzymes in murine fibrosarcoma cells
    F Okada
    Laboratory of Pathology, Cancer Institute, Hokkaido University School of Medicine, Sapporo, Japan
    Br J Cancer 79:377-85. 1999
  5. pmc Enhancement of in vitro prostaglandin E2 production by mouse fibrosarcoma cells after co-culture with various anti-tumour effector cells
    F Okada
    Laboratory of Cell Biology, Hokkaido University School of Medicine, Sapporo, Japan
    Br J Cancer 70:233-8. 1994
  6. pmc Transforming growth factor beta 1 (TGF-beta 1) produced in tumour tissue after chemotherapy acts as a lymphokine-activated killer attractant
    Y Kuramitsu
    Laboratory of Pathology, Hokkaido University School of Medicine, Sapporo, Japan
    Br J Cancer 74:274-9. 1996
  7. ncbi request reprint The LEC (Long-Evans Cinnamon) rat as an animal model for bilirubin-induced tooth pigmentation
    T Shibata
    Second Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Health Sciences University of Hokkaido, Japan
    Anticancer Res 17:2141-5. 1997
  8. ncbi request reprint Enhancement of tumor associated antigen expression during the regression phase of xenogenized tumor cell growth in vivo
    T Shibata
    Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Health Sciences University of Hokkaido, Japan
    Anticancer Res 17:2135-40. 1997
  9. ncbi request reprint Gelsolin functions as a metastasis suppressor in B16-BL6 mouse melanoma cells and requirement of the carboxyl-terminus for its effect
    H Fujita
    Division of Cancer Gene Regulation, Research Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Int J Cancer 93:773-80. 2001
  10. ncbi request reprint Overexpression of homeobox gene HOXD3 induces coordinate expression of metastasis-related genes in human lung cancer cells
    T Omatsu
    Division of Cancer-Related Genes, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Int J Cancer 93:516-25. 2001

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Inflammation and free radicals in tumor development and progression
    Futoshi Okada
    Division of Cancer Pathobiology, Research Section of Pathophysiology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 0815, Japan
    Redox Rep 7:357-68. 2002
    ..This article reviews the current findings linking inflammation and cancer, and shed light on inflammatory cell-derived free radicals as major endogenous reactive substances for tumor development and progression...
  2. ncbi request reprint Conversion of human colonic adenoma cells to adenocarcinoma cells through inflammation in nude mice
    F Okada
    Division of Cancer Pathobiology, Research Section of Pathophysiology, Institute for Genetic Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    Lab Invest 80:1617-28. 2000
    ..These results demonstrated that inflammation-associated stroma promoted the conversion of colonic adenoma cells to adenocarcinoma cells...
  3. ncbi request reprint Increased oxidative DNA damage in mammary tumor cells by continuous epidermal growth factor stimulation
    J Hamada
    Division of Cancer Related Genes, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    J Natl Cancer Inst 93:214-9. 2001
    ..In this study, we investigated the irreversible changes induced in ER-1 cells by a 1-month exposure to EGF and the possible involvement of oxidative stress...
  4. pmc Inflammatory cell-mediated tumour progression and minisatellite mutation correlate with the decrease of antioxidative enzymes in murine fibrosarcoma cells
    F Okada
    Laboratory of Pathology, Cancer Institute, Hokkaido University School of Medicine, Sapporo, Japan
    Br J Cancer 79:377-85. 1999
    ..These results suggest that tumour progression is accelerated by inflammation-induced active oxygen species particularly accompanied with declined levels of intracellular antioxidative enzymes in tumour cells...
  5. pmc Enhancement of in vitro prostaglandin E2 production by mouse fibrosarcoma cells after co-culture with various anti-tumour effector cells
    F Okada
    Laboratory of Cell Biology, Hokkaido University School of Medicine, Sapporo, Japan
    Br J Cancer 70:233-8. 1994
    ..001). These results suggest that oxygen radicals produced by anti-tumour effector cells and inflammatory cytokines provoke QR-32 cells to produce large amounts of immunosuppressive PGE2...
  6. pmc Transforming growth factor beta 1 (TGF-beta 1) produced in tumour tissue after chemotherapy acts as a lymphokine-activated killer attractant
    Y Kuramitsu
    Laboratory of Pathology, Hokkaido University School of Medicine, Sapporo, Japan
    Br J Cancer 74:274-9. 1996
    ..Taken together, we suggest that TGF-beta 1 produced in tumour tissues after chemotherapy participates in gathering transferred LAK cells and contributes to the therapeutic effects of transferred LAK cells...
  7. ncbi request reprint The LEC (Long-Evans Cinnamon) rat as an animal model for bilirubin-induced tooth pigmentation
    T Shibata
    Second Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Health Sciences University of Hokkaido, Japan
    Anticancer Res 17:2141-5. 1997
    ..The spectral characteristics indicated the presence of bilirubin in the pigmented teeth. Thus, the LEC rat may be useful animal model for bilirubin-induced tooth pigmentation...
  8. ncbi request reprint Enhancement of tumor associated antigen expression during the regression phase of xenogenized tumor cell growth in vivo
    T Shibata
    Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Health Sciences University of Hokkaido, Japan
    Anticancer Res 17:2135-40. 1997
    ....
  9. ncbi request reprint Gelsolin functions as a metastasis suppressor in B16-BL6 mouse melanoma cells and requirement of the carboxyl-terminus for its effect
    H Fujita
    Division of Cancer Gene Regulation, Research Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Int J Cancer 93:773-80. 2001
    ..Gelsolin may function as a metastasis suppressor as well as a tumor suppressor gene. The carboxyl-terminus of gelsolin is important for retardation of cell spreading, reduced chemotasis and metastasis suppression...
  10. ncbi request reprint Overexpression of homeobox gene HOXD3 induces coordinate expression of metastasis-related genes in human lung cancer cells
    T Omatsu
    Division of Cancer-Related Genes, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Int J Cancer 93:516-25. 2001
    ..These findings suggest that HOXD3 can act as a metastasis-promoting gene in human lung cancer A549 cells...
  11. pmc Malignant progression of a mouse fibrosarcoma by host cells reactive to a foreign body (gelatin sponge)
    F Okada
    Laboratory of Pathology, Hokkaido University School of Medicine, Sapporo, Japan
    Br J Cancer 66:635-9. 1992
    ..Preliminary in vitro studies implicated the involvement of hydrogen peroxide and hydroxyl radical as some of the factors necessary to induce QR-32 cells to produce high amounts of PGE2 and to accelerate tumour progression...
  12. ncbi request reprint Suppression of tumor growth by intra-muscular transfer of naked DNA encoding adrenomedullin antagonist
    T Miseki
    Division of Cancer Biology, Institute for Genetic Medicine, Hokkaido University, Hokkaido, Japan
    Cancer Gene Ther 14:39-44. 2007
    ..These results suggest that the intra-tumoral or intra-muscular transfer of naked DNA encoding AMA might be a promising alternative modality for treating human cancers...
  13. ncbi request reprint Effect of steroids on [18F]fluorodeoxyglucose uptake in an experimental tumour model
    S Zhao
    Department of Nuclear Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Nucl Med Commun 25:727-30. 2004
    ..To clarify this point, we determined the effects of steroids on FDG uptake in tumours in a rat model of a malignant tumour...
  14. ncbi request reprint Proteomic profiling for cancer progression: Differential display analysis for the expression of intracellular proteins between regressive and progressive cancer cell lines
    Eiko Hayashi
    Department of Biochemistry and Biomolecular Recognition, Yamaguchi University School of Medicine, Ube, Japan
    Proteomics 5:1024-32. 2005
    ..The results suggest an important complementary role for proteomics in identification of molecular abnormalities in tumor progression...
  15. ncbi request reprint Beyond foreign-body-induced carcinogenesis: impact of reactive oxygen species derived from inflammatory cells in tumorigenic conversion and tumor progression
    Futoshi Okada
    Department of Biomolecular Function, Graduate School of Medical Science, Yamagata University, Yamagata, Japan
    Int J Cancer 121:2364-72. 2007
    ....
  16. ncbi request reprint Inhibition of Akt kinase activity by a peptide spanning the betaA strand of the proto-oncogene TCL1
    Makoto Hiromura
    Division of Cancer Biology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    J Biol Chem 279:53407-18. 2004
    ..This observation will facilitate the design of specific inhibitors for Akt, a core intracellular survival factor underlying various human neoplastic diseases...
  17. ncbi request reprint Involvement of reactive nitrogen oxides for acquisition of metastatic properties of benign tumors in a model of inflammation-based tumor progression
    Futoshi Okada
    Department of Biomolecular Function, Graduate School of Medical Science, Yamagata University, Yamagata 990 9585, Japan
    Nitric Oxide 14:122-9. 2006
    ..These results showed that nitric oxide and its reactive nitrogen oxide species cooperatively play a pivotal role in the progression of benign tumor cells in inflamed lesions...
  18. ncbi request reprint siRNA gelsolin knockdown induces epithelial-mesenchymal transition with a cadherin switch in human mammary epithelial cells
    Hiroki Tanaka
    Division of Cancer Gene Regulation, Research Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Sapporo 060 0815, Japan
    Int J Cancer 118:1680-91. 2006
    ....
  19. ncbi request reprint Establishment and characterization of human urothelial cancer xenografts in severe combined immunodeficient mice
    Takashige Abe
    Department of Urology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Int J Urol 13:47-57. 2006
    ..To establish and characterize a murine xenograft model of human urothelial cancer in severe combined immunodeficient (SCID) mice for therapeutic simulation...
  20. pmc The role of nicotinamide adenine dinucleotide phosphate oxidase-derived reactive oxygen species in the acquisition of metastatic ability of tumor cells
    Futoshi Okada
    Department of Biomolecular Function, Graduate School of Medical Science, Yamagata University, 2 2 2, Iidanishi, Yamagata 990 9585 Japan
    Am J Pathol 169:294-302. 2006
    ....
  21. pmc Elevated oxidative stress in erythrocytes due to a SOD1 deficiency causes anaemia and triggers autoantibody production
    Yoshihito Iuchi
    Department of Biomolecular Function, Graduate School of Medical Science, Yamagata University, Yamagata, Japan
    Biochem J 402:219-27. 2007
    ....
  22. pmc Infiltration of neutrophils is required for acquisition of metastatic phenotype of benign murine fibrosarcoma cells: implication of inflammation-associated carcinogenesis and tumor progression
    Hiroshi Tazawa
    Divisions of Cancer Pathobiology and Cancer Related Genes Research, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Am J Pathol 163:2221-32. 2003
    ..These results suggested that inflammation, especially when neutrophils infiltrate into tumor tissue, is primarily important for benign tumor cells to acquire metastatic phenotype...