Affiliation: Hokkaido University
Ohta T, Kai T, Ito S. Evidence for paracrine modulation of voltage-dependent calcium channels by amperometric analysis in cultured porcine adrenal chromaffin cells. Brain Res. 2004;1030:183-92 pubmed
Ohta T, Kubota A, Murakami M, Otsuguro K, Ito S. P2X2 receptors are essential for [Ca2+]i increases in response to ATP in cultured rat myenteric neurons. Am J Physiol Gastrointest Liver Physiol. 2005;289:G935-48 pubmed
..A small part of the ATP-induced [Ca2+]i increase may be also mediated via a P2Y receptor-related mechanism. ..
Ohta T, Imagawa T, Ito S. Novel agonistic action of mustard oil on recombinant and endogenous porcine transient receptor potential V1 (pTRPV1) channels. Biochem Pharmacol. 2007;73:1646-56 pubmed
..These results provide an insight into the TRPV1-mediated effects of MO on inflammation and hyperalgesia. ..
Ohta T, Imagawa T, Ito S. Novel gating and sensitizing mechanism of capsaicin receptor (TRPV1): tonic inhibitory regulation of extracellular sodium through the external protonation sites on TRPV1. J Biol Chem. 2008;283:9377-87 pubmed publisher
Ohta T, Ikemi Y, Murakami M, Imagawa T, Otsuguro K, Ito S. Potentiation of transient receptor potential V1 functions by the activation of metabotropic 5-HT receptors in rat primary sensory neurons. J Physiol. 2006;576:809-22 pubmed
..Under inflammatory conditions, the increases of the biosynthesis of these 5-HT receptors may lead to further potentiation of TRPV1 functions, resulting in the generation of inflammatory hyperalgesia in vivo. ..