Toshio Ohta

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. request reprint
    Ohta T, Kubota A, Murakami M, Otsuguro K, Ito S. P2X2 receptors are essential for [Ca2+]i increases in response to ATP in cultured rat myenteric neurons. Am J Physiol Gastrointest Liver Physiol. 2005;289:G935-48 pubmed
    ..A small part of the ATP-induced [Ca2+]i increase may be also mediated via a P2Y receptor-related mechanism. ..
  2. request reprint
    Ohta T, Imagawa T, Ito S. Novel agonistic action of mustard oil on recombinant and endogenous porcine transient receptor potential V1 (pTRPV1) channels. Biochem Pharmacol. 2007;73:1646-56 pubmed
    ..These results provide an insight into the TRPV1-mediated effects of MO on inflammation and hyperalgesia. ..
  3. Ohta T, Imagawa T, Ito S. Novel gating and sensitizing mechanism of capsaicin receptor (TRPV1): tonic inhibitory regulation of extracellular sodium through the external protonation sites on TRPV1. J Biol Chem. 2008;283:9377-87 pubmed publisher
    ....
  4. Ohta T, Ikemi Y, Murakami M, Imagawa T, Otsuguro K, Ito S. Potentiation of transient receptor potential V1 functions by the activation of metabotropic 5-HT receptors in rat primary sensory neurons. J Physiol. 2006;576:809-22 pubmed
    ..Under inflammatory conditions, the increases of the biosynthesis of these 5-HT receptors may lead to further potentiation of TRPV1 functions, resulting in the generation of inflammatory hyperalgesia in vivo. ..

Locale

Detail Information

Publications4

  1. request reprint
    Ohta T, Kubota A, Murakami M, Otsuguro K, Ito S. P2X2 receptors are essential for [Ca2+]i increases in response to ATP in cultured rat myenteric neurons. Am J Physiol Gastrointest Liver Physiol. 2005;289:G935-48 pubmed
    ..A small part of the ATP-induced [Ca2+]i increase may be also mediated via a P2Y receptor-related mechanism. ..
  2. request reprint
    Ohta T, Imagawa T, Ito S. Novel agonistic action of mustard oil on recombinant and endogenous porcine transient receptor potential V1 (pTRPV1) channels. Biochem Pharmacol. 2007;73:1646-56 pubmed
    ..These results provide an insight into the TRPV1-mediated effects of MO on inflammation and hyperalgesia. ..
  3. Ohta T, Imagawa T, Ito S. Novel gating and sensitizing mechanism of capsaicin receptor (TRPV1): tonic inhibitory regulation of extracellular sodium through the external protonation sites on TRPV1. J Biol Chem. 2008;283:9377-87 pubmed publisher
    ....
  4. Ohta T, Ikemi Y, Murakami M, Imagawa T, Otsuguro K, Ito S. Potentiation of transient receptor potential V1 functions by the activation of metabotropic 5-HT receptors in rat primary sensory neurons. J Physiol. 2006;576:809-22 pubmed
    ..Under inflammatory conditions, the increases of the biosynthesis of these 5-HT receptors may lead to further potentiation of TRPV1 functions, resulting in the generation of inflammatory hyperalgesia in vivo. ..