M Niino

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. ncbi request reprint Recent advances in genetic analysis of multiple sclerosis: genetic associations and therapeutic implications
    Masaaki Niino
    Department of Neurology, Hokkaido University Hospital, Kita 14, Nishi 5, Kita ku, Sapporo 060 8648, Japan
    Expert Rev Neurother 7:1175-88. 2007
  2. ncbi request reprint Heat shock protein 70 gene polymorphism in Japanese patients with multiple sclerosis
    M Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Tissue Antigens 58:93-6. 2001
  3. ncbi request reprint Peroxisome proliferator-activated receptor agonists as potential therapeutic agents in multiple sclerosis
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo, 060 8638, Japan
    Mini Rev Med Chem 7:1129-35. 2007
  4. ncbi request reprint Therapeutic potential of vitamin D for multiple sclerosis
    Masaaki Niino
    Department of Neurology, Hokkaido University Hospital, Kita 14, Nishi 5, Kita ku, Sapporo 060 8648 Japan
    Curr Med Chem 15:499-505. 2008
  5. ncbi request reprint An examination of the association between beta2 adrenergic receptor polymorphisms and multiple sclerosis
    M Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Mult Scler 8:475-8. 2002
  6. pmc An examination of the Apo-1/Fas promoter Mva I polymorphism in Japanese patients with multiple sclerosis
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo, 060 8638, Japan
    BMC Neurol 2:8. 2002
  7. doi request reprint Memory and naïve B-cell subsets in patients with multiple sclerosis
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Neurosci Lett 464:74-8. 2009
  8. ncbi request reprint Genetic polymorphisms of osteopontin in association with multiple sclerosis in Japanese patients
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo, 060 8638, Japan
    J Neuroimmunol 136:125-9. 2003
  9. ncbi request reprint No association of vitamin D-binding protein gene polymorphisms in Japanese patients with MS
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo 060 8638, Japan
    J Neuroimmunol 127:177-9. 2002
  10. ncbi request reprint Estrogens as potential therapeutic agents in multiple sclerosis
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kitaku, Sapporo, Japan
    Cent Nerv Syst Agents Med Chem 9:87-94. 2009

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Recent advances in genetic analysis of multiple sclerosis: genetic associations and therapeutic implications
    Masaaki Niino
    Department of Neurology, Hokkaido University Hospital, Kita 14, Nishi 5, Kita ku, Sapporo 060 8648, Japan
    Expert Rev Neurother 7:1175-88. 2007
    ..Newer techniques and methods of analysis will hopefully result in better screening of individuals who are at highest risk and novel treatments...
  2. ncbi request reprint Heat shock protein 70 gene polymorphism in Japanese patients with multiple sclerosis
    M Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Tissue Antigens 58:93-6. 2001
    ..Our data indicate that HSP70 gene polymorphisms are not relevant in the susceptibility to or the severity of Japanese MS patients...
  3. ncbi request reprint Peroxisome proliferator-activated receptor agonists as potential therapeutic agents in multiple sclerosis
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo, 060 8638, Japan
    Mini Rev Med Chem 7:1129-35. 2007
    ..This article will outline current experimental evidence suggesting potential clinical benefits for patients with MS...
  4. ncbi request reprint Therapeutic potential of vitamin D for multiple sclerosis
    Masaaki Niino
    Department of Neurology, Hokkaido University Hospital, Kita 14, Nishi 5, Kita ku, Sapporo 060 8648 Japan
    Curr Med Chem 15:499-505. 2008
    ..This review also discusses the therapeutic potential of vitamin D for treating MS...
  5. ncbi request reprint An examination of the association between beta2 adrenergic receptor polymorphisms and multiple sclerosis
    M Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Mult Scler 8:475-8. 2002
    ..Together, our findings suggest that the presence of beta2AR gene polymorphisms may be inconclusive in the susceptibility to MS or in the clinical characteristics of Japanese patients with MS and, therefore, need further studies...
  6. pmc An examination of the Apo-1/Fas promoter Mva I polymorphism in Japanese patients with multiple sclerosis
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo, 060 8638, Japan
    BMC Neurol 2:8. 2002
    ..The Apo-1/Fas gene is located in a chromosomal region that shows linkage in multiple sclerosis (MS) genome screens, and studies indicate that there is aberrant expression of the Apo-1/Fas molecule in MS...
  7. doi request reprint Memory and naïve B-cell subsets in patients with multiple sclerosis
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Neurosci Lett 464:74-8. 2009
    ..These results indicate that memory and naïve B-cell subsets, especially CD86(+) naïve B cells, CCR5(+) naïve B cells, and CD5(+) memory B cells, might be useful in the study of the pathogenesis of and therapy for MS...
  8. ncbi request reprint Genetic polymorphisms of osteopontin in association with multiple sclerosis in Japanese patients
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo, 060 8638, Japan
    J Neuroimmunol 136:125-9. 2003
    ..Our results suggest that the 8090th polymorphism might be associated with susceptibility to MS, while the 9583rd polymorphism might be associated with age of onset of MS...
  9. ncbi request reprint No association of vitamin D-binding protein gene polymorphisms in Japanese patients with MS
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo 060 8638, Japan
    J Neuroimmunol 127:177-9. 2002
    ..Furthermore, no association was observed between the DBP polymorphisms and the age at disease onset. These results suggest that DBP does not contribute to the development of MS in Japanese...
  10. ncbi request reprint Estrogens as potential therapeutic agents in multiple sclerosis
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kitaku, Sapporo, Japan
    Cent Nerv Syst Agents Med Chem 9:87-94. 2009
    ..In this review paper, we discuss increasing evidence that points to a link between estrogen and MS. We also analyze the therapeutic potential of estrogens in MS and review current genetic studies on ER...
  11. ncbi request reprint Vitamin D receptor gene polymorphism in multiple sclerosis and the association with HLA class II alleles
    M Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, 060 8638, Sapporo, Japan
    J Neurol Sci 177:65-71. 2000
    ..0308 and P(corr)=0.0033, respectively). These results indicate that VDRG polymorphism may be associated with susceptibility to MS, and HLA alleles may correlate with risk for MS together with VDRG...
  12. ncbi request reprint Estrogen receptor gene polymorphism in Japanese patients with multiple sclerosis
    M Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, 060 8638, Sapporo, Japan
    J Neurol Sci 179:70-5. 2000
    ..ERG polymorphism should be further studied in other populations to improve strategies for treatment of MS...
  13. ncbi request reprint Macrophage migration inhibitory factor in the cerebrospinal fluid of patients with conventional and optic-spinal forms of multiple sclerosis and neuro-Behçet's disease
    M Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, 060 8638, Sapporo, Japan
    J Neurol Sci 179:127-31. 2000
    ..910, P<0.005). These results suggest that MIF may play a pivotal role in immune-mediated diseases of the central nervous system, and that MIF may be useful in the study of differences between C-MS and OpS-MS...
  14. ncbi request reprint Genetic polymorphisms of IL-1beta and IL-1 receptor antagonist in association with multiple sclerosis in Japanese patients
    M Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, 060 8638, Sapporo, Japan
    J Neuroimmunol 118:295-9. 2001
    ..Together, our findings suggest that IL-1beta or IL-1ra gene polymorphisms may not be relevant in the susceptibility to MS or the clinical characteristics of Japanese patients with MS...
  15. ncbi request reprint Update on the treatment options for multiple sclerosis
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Expert Rev Clin Immunol 6:77-88. 2010
    ..Here, we review the recent progress in current therapeutic strategies for MS, and the potential options for future MS treatment...
  16. ncbi request reprint Polymorphisms of apolipoprotein E and Japanese patients with multiple sclerosis
    M Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Mult Scler 9:382-6. 2003
    ..Although the low rate of epsilon4 allele in Japan should be taken into consideration, our results showed no relation between APOE gene polymorphisms and Japanese patients with MS...
  17. doi request reprint Relationship between Barkhof criteria and the clinical features of multiple sclerosis in northern Japan
    M Nakamura
    Department of Neurology, Obihiro Kosei General Hospital, Obihiro, Japan
    Mult Scler 15:1450-8. 2009
    ....
  18. ncbi request reprint HLA-related subpopulations of MS in Japanese with and without oligoclonal IgG bands. Human leukocyte antigen
    S Kikuchi
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Neurology 60:647-51. 2003
    ....
  19. doi request reprint Expansion of CD4+CD28- T cells producing high levels of interferon-{gamma} in peripheral blood of patients with multiple sclerosis
    Y Miyazaki
    Division of Immunobiology, Research Section of Pathophysiology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Mult Scler 14:1044-55. 2008
    ..Thus, an additional treatment strategy that specifically targets this cell population may enhance the beneficial effect of IFN-beta on MS...
  20. ncbi request reprint Amelioration of experimental autoimmune encephalomyelitis in C57BL/6 mice by an agonist of peroxisome proliferator-activated receptor-gamma
    M Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita-15 Nishi-7, Kita-ku, 060-8638, Sapporo, Japan
    J Neuroimmunol 116:40-8. 2001
    ..We found that troglitazone attenuated the inflammation and decreased the clinical symptoms. It was suggested that the amelioration was attributed to the attenuation of pro-inflammatory cytokine gene expressions...
  21. doi request reprint Increasing prevalence and incidence of multiple sclerosis in northern Japan
    H Houzen
    Department of Neurology, Obihiro Kosei General Hospital, Obihiro, Japan
    Mult Scler 14:887-92. 2008
    ..A second epidemiologic survey was conducted to assess changes in MS prevalence and incidence over the last 30 years in Tokachi province of Hokkaido, the northernmost island of Japan...
  22. ncbi request reprint C-C chemokine receptor 2 gene polymorphism in Japanese patients with multiple sclerosis
    Ryuji Miyagishi
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita, Sapporo 060 8638, Hokkaido, Japan
    J Neuroimmunol 145:135-8. 2003
    ..0204). There were no significant associations between CCR2 polymorphism and the clinical features of MS. Our results indicate that the presence of CCR2-64I allele seems to provide protection against the development of MS...
  23. doi request reprint Correlation between DJ-1 levels in the cerebrospinal fluid and the progression of disabilities in multiple sclerosis patients
    M Hirotani
    Department of Neurology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Mult Scler 14:1056-60. 2008
    ..The aim of this study was to investigate whether the DJ-1 levels were increased in patients with MS and to examine its association with the progression of MS...
  24. ncbi request reprint Platelet-activating factor receptor gene polymorphism in Japanese patients with multiple sclerosis
    Manabu Osoegawa
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neuroimmunol 161:195-8. 2005
    ..7%) was also significantly higher than those in healthy controls (6.9%) (p=0.019; OR, 1.78; 95% CI, 1.10-2.89). These findings suggest that the PAFR gene missense mutation has a relation to the susceptibility for MS...
  25. ncbi request reprint An assessment of the association between IL-2 gene polymorphisms and Japanese patients with multiple sclerosis
    Seiji Kikuchi
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, 060 8638 Sapporo, Japan
    J Neurol Sci 205:47-50. 2002
    ..Together, our findings suggest that IL-2 gene polymorphisms do not influence the susceptibility to MS or the clinical characteristics of MS in Japanese patients...
  26. doi request reprint Impact of screening with thyroid ultrasonography in myasthenia gravis patients
    E Maruyama
    Department of Clinical Laboratory, Hokkaido Medical Center, Sapporo, Japan
    Acta Neurol Scand 125:398-402. 2012
    ..This study was conducted to screen thyroid abnormality evaluated with ultrasonography (US) in patients with myasthenia gravis (MG) and investigate further when malignancy is suspected...
  27. ncbi request reprint The role of B cells in multiple sclerosis: implications for B-cell-targeted therapy
    M Hirotani
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kitaku, Sapporo, Japan
    Curr Med Chem 17:3215-22. 2010
    ..In this article, we review the increasing evidence that points to a link between B cells and MS, and also discuss the potential of B-cell-targeted therapy in MS...
  28. doi request reprint Downbeat positioning nystagmus is a common clinical feature despite variable phenotypes in an FHM1 family
    Ichiro Yabe
    Department of Neurology, Hokkaido University Graduate School of Medicine, N15 W7 Kita ku, Sapporo 060 8638, Japan
    J Neurol 255:1541-4. 2008
    ..Although clinical features associated with the T666M CACNA1A mutation are highly variable, downbeat positioning nystagmus may be an important clinical feature of this disease...
  29. ncbi request reprint Chronic inflammatory demyelinating polyneuropathy after treatment with interferon-alpha
    Makoto Hirotani
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo
    Intern Med 48:373-5. 2009
    ..This case may therefore provide an important clue to understand the immune mechanism of CIDP and IFN-alpha...
  30. ncbi request reprint Brefeldin A-induced neurotoxicity in cultured spinal cord neurons
    Seiji Kikuchi
    Department of Neurology, Hokkaido University School of Medicine, Sapporo, Hokkaido, Japan
    J Neurosci Res 71:591-9. 2003
    ..This in vitro model may be useful in attempts to study the mechanisms of this neurodegenerative disease and to examine therapeutic potentials...
  31. ncbi request reprint Effect of proteasome inhibitor on cultured mesencephalic dopaminergic neurons
    Seiji Kikuchi
    Department of Neurology, Hokkaido University School of Medicine, Kita 15, Nishi 7, Kita ku, Hokkaido, Sapporo, Japan
    Brain Res 964:228-36. 2003
    ..Our results suggest that proteasome inhibition causes the neurotoxicity in mesencephalic neurons, but that is not sufficient to reproduce the selective damage to dopaminergic neurons, such as that seen in PD...
  32. ncbi request reprint Effect of geranylgeranylaceton on cellular damage induced by proteasome inhibition in cultured spinal neurons
    Seiji Kikuchi
    Department of Neurology, Hokkaido University School of Medicine, Sapporo, Japan
    J Neurosci Res 69:373-81. 2002
    ....
  33. ncbi request reprint Estrogen receptor gene polymorphism and multiple sclerosis in Japanese patients: interaction with HLA-DRB1*1501 and disease modulation
    Seiji Kikuchi
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nshi 7, Kita ku, Sapporo 060 8638, Japan
    J Neuroimmunol 128:77-81. 2002
    ..0001). The [P] allele-positive patients with disease duration of more than 5 years had a significantly higher progression index (PI) of disability (p=0.0230) and a worse ranked MS severity score (p=0.0152) than their non-[P] counterparts...
  34. ncbi request reprint Platelet-activating factor acetylhydrolase gene polymorphism and its activity in Japanese patients with multiple sclerosis
    Manabu Osoegawa
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neuroimmunol 150:150-6. 2004
    ....
  35. pmc Focal (segmental) dyshidrosis in syringomyelia
    K Sudo
    Department of Neurology, Hokkaido University School of Medicine, Sapporo, Japan
    J Neurol Neurosurg Psychiatry 67:106-8. 1999
    ..Focal hyperhidrosis may be regarded as a hallmark of a relatively intact spinal cord, as well as normohidrosis...
  36. doi request reprint Vitamin D and its immunoregulatory role in multiple sclerosis
    Masaaki Niino
    Department of Clinical Research, Hokkaido Medical Center, Nishi ku, Sapporo, Japan
    Drugs Today (Barc) 46:279-90. 2010
    ..The current review discusses the immunological functions of vitamin D, the association between vitamin D and MS and expectations regarding the role of vitamin D in future treatments of MS...
  37. ncbi request reprint The prevalence and clinical characteristics of MS in northern Japan
    Hideki Houzen
    Department of Neurology, Obihiro Kosei General Hospital, Obihiro, Japan
    J Neurol Sci 211:49-53. 2003
    ..In contrast to the previous reports in Japan, there was a relatively low frequency of OS-MS in Hokkaido...
  38. ncbi request reprint Comparison of the clinical courses of the opticospinal and conventional forms of multiple sclerosis in Japan
    Manabu Osoegawa
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Intern Med 44:934-8. 2005
    ..These results suggest that the irreversible disability in OS-MS is determined by relapses, rather than by chronic progression, whereas C-MS has a similar clinical course to MS in Westerners...
  39. ncbi request reprint [Approach to find new therapies for MS from clinical view]
    Masaaki Niino
    Department of Neurology, Hokkaido University Hospital
    Rinsho Shinkeigaku 48:935-6. 2008
    ..In the near future, studies on susceptibility genes and pharmacogenetics will provide invaluable information concerning new drugs for the treatment of MS and better therapeutic regimens for MS patients...
  40. ncbi request reprint Long-term blood pressure variability and cerebrovascular changes on CT in a community-based elderly population
    E Tsukishima
    Department of Public Health, Hokkaido University Graduate School of Medicine, Japan
    J Epidemiol 11:190-8. 2001
    ..3, 1.1-4.9), but not with WML (adjusted OR, 95%CI, 1.3, 0.5-3.3). Efforts to prevent both DHT and ISHT would be beneficial, though different underlying mechanisms for WML and SI were suggested...
  41. ncbi request reprint Prostaglandin E1 protects cultured spinal neurons against the effects of nitric oxide toxicity
    S Kikuchi
    Department of Neurology, Hokkaido University School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Neuropharmacology 42:714-23. 2002
    ..Our data indicate that PGE(1) exerts a protective action against NO neurotoxicity in cultured spinal neurons, and suggests a therapeutic potential of PGE(1) against spinal cord disease, such as amyotrophic lateral sclerosis...
  42. doi request reprint Clinical characterization and successful treatment of 6 patients with Churg-Strauss syndrome-associated neuropathy
    Masakazu Nakamura
    Department of Neurology, Hokkaido University Graduate School of Medicine, N15W7, Kita ku, Sapporo 060 8638, Japan
    Clin Neurol Neurosurg 111:683-7. 2009
    ..To confirm the reported findings and clarify unknown clinical features of Churg-Strauss syndrome (CSS)-associated neuropathy and design appropriate treatment...
  43. doi request reprint Decreased IL-10 production mediated by Toll-like receptor 9 in B cells in multiple sclerosis
    Makoto Hirotani
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Neuroimmunol 221:95-100. 2010
    ..Our results indicate that TLR9-mediated IL-10 production by B cells was significantly decreased in MS, and this decrease is likely due to decreased TLR9 expression in memory B cells, suggesting a role of TLR9 in immunoregulation in MS...
  44. ncbi request reprint Cystatin C in cerebrospinal fluid as a biomarker of ALS
    Sachiko Tsuji-Akimoto
    Department of Neurology, Graduate School of Medicine, Hokkaido University, Sapporo City, Hokkaido, Japan
    Neurosci Lett 452:52-5. 2009
    ..control subjects: p = 0.014 and ALS patients vs. polyneuropathy patients: p = 0.024). Cystatin C may be a useful biomarker of ALS and can be used to distinguish between ALS and polyneuropathy...
  45. ncbi request reprint Intracranial hemorrhage in neuro-Behçet's syndrome
    Seiji Kikuchi
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo
    Intern Med 41:692-5. 2002
    ..In this paper, we report three cases of neuro-Behçet's syndrome presenting with intracerebral hemorrhaging, and discuss the possible causes as they relate to cyclosporine treatment...
  46. doi request reprint MRI and pathological findings of rheumatoid meningitis
    Masaaki Matsushima
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    J Clin Neurosci 17:129-32. 2010
    ..RM is a treatable disease and in this patient RM was diagnosed on the basis of biopsy findings...
  47. ncbi request reprint Vitamin D receptor gene polymorphism affects onset pattern of type 1 diabetes
    Yoshiko Motohashi
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Clin Endocrinol Metab 88:3137-40. 2003
    ..Assessment of this VDR gene polymorphism may contribute to prediction of the onset pattern in individuals with a high risk of type 1 diabetes...
  48. ncbi request reprint CTLA-4 gene polymorphism is not associated with conventional multiple sclerosis in Japanese
    Toshiyuki Fukazawa
    Hokuyukai Neurology Hospital, Niju Yon Ken 2 2 4 30, Nishi ku, Sapporo 063 0802, Japan
    J Neuroimmunol 159:225-9. 2005
    ....
  49. ncbi request reprint [Susceptibility genes for multiple sclerosis]
    Toshiyuki Fukazawa
    Hokuyukai Neurology Hospital
    Nihon Rinsho 61:1311-6. 2003
    ..Appropriate case ascertainment and collection as well as proper statistical method are needed to isolate the susceptibility genes for MS...
  50. doi request reprint Baló's concentric sclerosislike lesion in the brainstem of a multiple sclerosis patient
    Richiro Kishimoto
    J Neurol 255:760-1. 2008
  51. ncbi request reprint Attack-related severity: a key factor in understanding the spectrum of idiopathic inflammatory demyelinating disorders
    Toshiyuki Fukazawa
    Hokuyukai Neurology Hospital, Niju Yon Ken 2 2 4 30, Nishi ku, Sapporo 063 0802, Japan
    J Neurol Sci 225:71-8. 2004
    ..Attack-related severity may be an important factor if validated by prospective studies defining criteria and establishing relationships to disease course and treatment regimens...
  52. ncbi request reprint Induction of antigen-specific tolerance in multiple sclerosis after immunization with DNA encoding myelin basic protein in a randomized, placebo-controlled phase 1/2 trial
    Amit Bar-Or
    Montreal Neurological Institute, Montreal, Quebec, Canada
    Arch Neurol 64:1407-15. 2007
    ..To assess safety and immune modulation by BHT-3009, a tolerizing DNA vaccine encoding full-length human myelin basic protein, in patients with multiple sclerosis (MS)...
  53. ncbi request reprint Altered CD4+/CD8+ T-cell ratios in cerebrospinal fluid of natalizumab-treated patients with multiple sclerosis
    Olaf Stuve
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, USA
    Arch Neurol 63:1383-7. 2006
    ....
  54. ncbi request reprint Natalizumab effects on immune cell responses in multiple sclerosis
    Masaaki Niino
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Quebec, Canada
    Ann Neurol 59:748-54. 2006
    ..Our objective was to study in vivo biological effects of natalizumab on immune cell phenotype and function in multiple sclerosis (MS) patients...
  55. ncbi request reprint Multiphasic demyelinating disorder with acute transverse myelitis in Japanese
    Toshiyuki Fukazawa
    J Neurol 250:624-6. 2003
  56. ncbi request reprint Subacute syphilitic meningomyelitis with characteristic spinal MRI findings
    Seiji Kikuchi
    J Neurol 250:106-7. 2003
  57. ncbi request reprint Distinct effector cytokine profiles of memory and naive human B cell subsets and implication in multiple sclerosis
    Martin Duddy
    Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, and Department of Neurology, Ottawa General Hospital, Canada
    J Immunol 178:6092-9. 2007
    ..Our findings are of particular relevance at a time when B cell directed therapies are being applied to clinical trials of several autoimmune diseases...