Research Topics
Genomes and Genes | M NiinoSummaryAffiliation: Hokkaido University Country: Japan Publications
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Publications
Recent advances in genetic analysis of multiple sclerosis: genetic associations and therapeutic implicationsMasaaki Niino
Department of Neurology, Hokkaido University Hospital, Kita 14, Nishi 5, Kita ku, Sapporo 060 8648, Japan
Expert Rev Neurother 7:1175-88. 2007..Newer techniques and methods of analysis will hopefully result in better screening of individuals who are at highest risk and novel treatments...- Heat shock protein 70 gene polymorphism in Japanese patients with multiple sclerosisM Niino
Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Tissue Antigens 58:93-6. 2001..Our data indicate that HSP70 gene polymorphisms are not relevant in the susceptibility to or the severity of Japanese MS patients... - Peroxisome proliferator-activated receptor agonists as potential therapeutic agents in multiple sclerosisMasaaki Niino
Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo, 060 8638, Japan
Mini Rev Med Chem 7:1129-35. 2007..This article will outline current experimental evidence suggesting potential clinical benefits for patients with MS... - Therapeutic potential of vitamin D for multiple sclerosisMasaaki Niino
Department of Neurology, Hokkaido University Hospital, Kita 14, Nishi 5, Kita ku, Sapporo 060 8648 Japan
Curr Med Chem 15:499-505. 2008..This review also discusses the therapeutic potential of vitamin D for treating MS... - An examination of the association between beta2 adrenergic receptor polymorphisms and multiple sclerosisM Niino
Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo 060 8638, Japan
Mult Scler 8:475-8. 2002..Together, our findings suggest that the presence of beta2AR gene polymorphisms may be inconclusive in the susceptibility to MS or in the clinical characteristics of Japanese patients with MS and, therefore, need further studies... 
An examination of the Apo-1/Fas promoter Mva I polymorphism in Japanese patients with multiple sclerosisMasaaki Niino
Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo, 060 8638, Japan
BMC Neurol 2:8. 2002..The Apo-1/Fas gene is located in a chromosomal region that shows linkage in multiple sclerosis (MS) genome screens, and studies indicate that there is aberrant expression of the Apo-1/Fas molecule in MS...
Memory and naïve B-cell subsets in patients with multiple sclerosisMasaaki Niino
Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Neurosci Lett 464:74-8. 2009..These results indicate that memory and naïve B-cell subsets, especially CD86(+) naïve B cells, CCR5(+) naïve B cells, and CD5(+) memory B cells, might be useful in the study of the pathogenesis of and therapy for MS...- Genetic polymorphisms of osteopontin in association with multiple sclerosis in Japanese patientsMasaaki Niino
Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo, 060 8638, Japan
J Neuroimmunol 136:125-9. 2003..Our results suggest that the 8090th polymorphism might be associated with susceptibility to MS, while the 9583rd polymorphism might be associated with age of onset of MS... - No association of vitamin D-binding protein gene polymorphisms in Japanese patients with MSMasaaki Niino
Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo 060 8638, Japan
J Neuroimmunol 127:177-9. 2002..Furthermore, no association was observed between the DBP polymorphisms and the age at disease onset. These results suggest that DBP does not contribute to the development of MS in Japanese... - Estrogens as potential therapeutic agents in multiple sclerosisMasaaki Niino
Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kitaku, Sapporo, Japan
Cent Nerv Syst Agents Med Chem 9:87-94. 2009..In this review paper, we discuss increasing evidence that points to a link between estrogen and MS. We also analyze the therapeutic potential of estrogens in MS and review current genetic studies on ER... - Vitamin D receptor gene polymorphism in multiple sclerosis and the association with HLA class II allelesM Niino
Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, 060 8638, Sapporo, Japan
J Neurol Sci 177:65-71. 2000..0308 and P(corr)=0.0033, respectively). These results indicate that VDRG polymorphism may be associated with susceptibility to MS, and HLA alleles may correlate with risk for MS together with VDRG... - Estrogen receptor gene polymorphism in Japanese patients with multiple sclerosisM Niino
Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, 060 8638, Sapporo, Japan
J Neurol Sci 179:70-5. 2000..ERG polymorphism should be further studied in other populations to improve strategies for treatment of MS... - Macrophage migration inhibitory factor in the cerebrospinal fluid of patients with conventional and optic-spinal forms of multiple sclerosis and neuro-Behçet's diseaseM Niino
Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, 060 8638, Sapporo, Japan
J Neurol Sci 179:127-31. 2000..910, P<0.005). These results suggest that MIF may play a pivotal role in immune-mediated diseases of the central nervous system, and that MIF may be useful in the study of differences between C-MS and OpS-MS... - Genetic polymorphisms of IL-1beta and IL-1 receptor antagonist in association with multiple sclerosis in Japanese patientsM Niino
Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, 060 8638, Sapporo, Japan
J Neuroimmunol 118:295-9. 2001..Together, our findings suggest that IL-1beta or IL-1ra gene polymorphisms may not be relevant in the susceptibility to MS or the clinical characteristics of Japanese patients with MS... - Update on the treatment options for multiple sclerosisMasaaki Niino
Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo 060 8638, Japan
Expert Rev Clin Immunol 6:77-88. 2010..Here, we review the recent progress in current therapeutic strategies for MS, and the potential options for future MS treatment... - Polymorphisms of apolipoprotein E and Japanese patients with multiple sclerosisM Niino
Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo 060 8638, Japan
Mult Scler 9:382-6. 2003..Although the low rate of epsilon4 allele in Japan should be taken into consideration, our results showed no relation between APOE gene polymorphisms and Japanese patients with MS... - Relationship between Barkhof criteria and the clinical features of multiple sclerosis in northern JapanM Nakamura
Department of Neurology, Obihiro Kosei General Hospital, Obihiro, Japan
Mult Scler 15:1450-8. 2009.... - HLA-related subpopulations of MS in Japanese with and without oligoclonal IgG bands. Human leukocyte antigenS Kikuchi
Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Neurology 60:647-51. 2003.... - Expansion of CD4+CD28- T cells producing high levels of interferon-{gamma} in peripheral blood of patients with multiple sclerosisY Miyazaki
Division of Immunobiology, Research Section of Pathophysiology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
Mult Scler 14:1044-55. 2008..Thus, an additional treatment strategy that specifically targets this cell population may enhance the beneficial effect of IFN-beta on MS... - Amelioration of experimental autoimmune encephalomyelitis in C57BL/6 mice by an agonist of peroxisome proliferator-activated receptor-gammaM Niino
Department of Neurology, Hokkaido University Graduate School of Medicine, Kita-15 Nishi-7, Kita-ku, 060-8638, Sapporo, Japan
J Neuroimmunol 116:40-8. 2001..We found that troglitazone attenuated the inflammation and decreased the clinical symptoms. It was suggested that the amelioration was attributed to the attenuation of pro-inflammatory cytokine gene expressions... - Increasing prevalence and incidence of multiple sclerosis in northern JapanH Houzen
Department of Neurology, Obihiro Kosei General Hospital, Obihiro, Japan
Mult Scler 14:887-92. 2008..A second epidemiologic survey was conducted to assess changes in MS prevalence and incidence over the last 30 years in Tokachi province of Hokkaido, the northernmost island of Japan... - C-C chemokine receptor 2 gene polymorphism in Japanese patients with multiple sclerosisRyuji Miyagishi
Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita, Sapporo 060 8638, Hokkaido, Japan
J Neuroimmunol 145:135-8. 2003..0204). There were no significant associations between CCR2 polymorphism and the clinical features of MS. Our results indicate that the presence of CCR2-64I allele seems to provide protection against the development of MS... - Correlation between DJ-1 levels in the cerebrospinal fluid and the progression of disabilities in multiple sclerosis patientsM Hirotani
Department of Neurology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Mult Scler 14:1056-60. 2008..The aim of this study was to investigate whether the DJ-1 levels were increased in patients with MS and to examine its association with the progression of MS... - Platelet-activating factor receptor gene polymorphism in Japanese patients with multiple sclerosisManabu Osoegawa
Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
J Neuroimmunol 161:195-8. 2005..7%) was also significantly higher than those in healthy controls (6.9%) (p=0.019; OR, 1.78; 95% CI, 1.10-2.89). These findings suggest that the PAFR gene missense mutation has a relation to the susceptibility for MS... - An assessment of the association between IL-2 gene polymorphisms and Japanese patients with multiple sclerosisSeiji Kikuchi
Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, 060 8638 Sapporo, Japan
J Neurol Sci 205:47-50. 2002..Together, our findings suggest that IL-2 gene polymorphisms do not influence the susceptibility to MS or the clinical characteristics of MS in Japanese patients... - Impact of screening with thyroid ultrasonography in myasthenia gravis patientsE Maruyama
Department of Clinical Laboratory, Hokkaido Medical Center, Sapporo, Japan
Acta Neurol Scand 125:398-402. 2012..This study was conducted to screen thyroid abnormality evaluated with ultrasonography (US) in patients with myasthenia gravis (MG) and investigate further when malignancy is suspected... - The role of B cells in multiple sclerosis: implications for B-cell-targeted therapyM Hirotani
Department of Neurology, Hokkaido University Graduate School of Medicine, Kitaku, Sapporo, Japan
Curr Med Chem 17:3215-22. 2010..In this article, we review the increasing evidence that points to a link between B cells and MS, and also discuss the potential of B-cell-targeted therapy in MS... - Downbeat positioning nystagmus is a common clinical feature despite variable phenotypes in an FHM1 familyIchiro Yabe
Department of Neurology, Hokkaido University Graduate School of Medicine, N15 W7 Kita ku, Sapporo 060 8638, Japan
J Neurol 255:1541-4. 2008..Although clinical features associated with the T666M CACNA1A mutation are highly variable, downbeat positioning nystagmus may be an important clinical feature of this disease... - Chronic inflammatory demyelinating polyneuropathy after treatment with interferon-alphaMakoto Hirotani
Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo
Intern Med 48:373-5. 2009..This case may therefore provide an important clue to understand the immune mechanism of CIDP and IFN-alpha... - Brefeldin A-induced neurotoxicity in cultured spinal cord neuronsSeiji Kikuchi
Department of Neurology, Hokkaido University School of Medicine, Sapporo, Hokkaido, Japan
J Neurosci Res 71:591-9. 2003..This in vitro model may be useful in attempts to study the mechanisms of this neurodegenerative disease and to examine therapeutic potentials... - Effect of proteasome inhibitor on cultured mesencephalic dopaminergic neuronsSeiji Kikuchi
Department of Neurology, Hokkaido University School of Medicine, Kita 15, Nishi 7, Kita ku, Hokkaido, Sapporo, Japan
Brain Res 964:228-36. 2003..Our results suggest that proteasome inhibition causes the neurotoxicity in mesencephalic neurons, but that is not sufficient to reproduce the selective damage to dopaminergic neurons, such as that seen in PD... - Effect of geranylgeranylaceton on cellular damage induced by proteasome inhibition in cultured spinal neuronsSeiji Kikuchi
Department of Neurology, Hokkaido University School of Medicine, Sapporo, Japan
J Neurosci Res 69:373-81. 2002.... - Estrogen receptor gene polymorphism and multiple sclerosis in Japanese patients: interaction with HLA-DRB1*1501 and disease modulationSeiji Kikuchi
Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nshi 7, Kita ku, Sapporo 060 8638, Japan
J Neuroimmunol 128:77-81. 2002..0001). The [P] allele-positive patients with disease duration of more than 5 years had a significantly higher progression index (PI) of disability (p=0.0230) and a worse ranked MS severity score (p=0.0152) than their non-[P] counterparts... - Platelet-activating factor acetylhydrolase gene polymorphism and its activity in Japanese patients with multiple sclerosisManabu Osoegawa
Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
J Neuroimmunol 150:150-6. 2004.... - Focal (segmental) dyshidrosis in syringomyeliaK Sudo
Department of Neurology, Hokkaido University School of Medicine, Sapporo, Japan
J Neurol Neurosurg Psychiatry 67:106-8. 1999..Focal hyperhidrosis may be regarded as a hallmark of a relatively intact spinal cord, as well as normohidrosis... - Vitamin D and its immunoregulatory role in multiple sclerosisMasaaki Niino
Department of Clinical Research, Hokkaido Medical Center, Nishi ku, Sapporo, Japan
Drugs Today (Barc) 46:279-90. 2010..The current review discusses the immunological functions of vitamin D, the association between vitamin D and MS and expectations regarding the role of vitamin D in future treatments of MS... - The prevalence and clinical characteristics of MS in northern JapanHideki Houzen
Department of Neurology, Obihiro Kosei General Hospital, Obihiro, Japan
J Neurol Sci 211:49-53. 2003..In contrast to the previous reports in Japan, there was a relatively low frequency of OS-MS in Hokkaido... - Comparison of the clinical courses of the opticospinal and conventional forms of multiple sclerosis in JapanManabu Osoegawa
Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Intern Med 44:934-8. 2005..These results suggest that the irreversible disability in OS-MS is determined by relapses, rather than by chronic progression, whereas C-MS has a similar clinical course to MS in Westerners... - [Approach to find new therapies for MS from clinical view]Masaaki Niino
Department of Neurology, Hokkaido University Hospital
Rinsho Shinkeigaku 48:935-6. 2008..In the near future, studies on susceptibility genes and pharmacogenetics will provide invaluable information concerning new drugs for the treatment of MS and better therapeutic regimens for MS patients... - Long-term blood pressure variability and cerebrovascular changes on CT in a community-based elderly populationE Tsukishima
Department of Public Health, Hokkaido University Graduate School of Medicine, Japan
J Epidemiol 11:190-8. 2001..3, 1.1-4.9), but not with WML (adjusted OR, 95%CI, 1.3, 0.5-3.3). Efforts to prevent both DHT and ISHT would be beneficial, though different underlying mechanisms for WML and SI were suggested... - Prostaglandin E1 protects cultured spinal neurons against the effects of nitric oxide toxicityS Kikuchi
Department of Neurology, Hokkaido University School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
Neuropharmacology 42:714-23. 2002..Our data indicate that PGE(1) exerts a protective action against NO neurotoxicity in cultured spinal neurons, and suggests a therapeutic potential of PGE(1) against spinal cord disease, such as amyotrophic lateral sclerosis... - Clinical characterization and successful treatment of 6 patients with Churg-Strauss syndrome-associated neuropathyMasakazu Nakamura
Department of Neurology, Hokkaido University Graduate School of Medicine, N15W7, Kita ku, Sapporo 060 8638, Japan
Clin Neurol Neurosurg 111:683-7. 2009..To confirm the reported findings and clarify unknown clinical features of Churg-Strauss syndrome (CSS)-associated neuropathy and design appropriate treatment... - Decreased IL-10 production mediated by Toll-like receptor 9 in B cells in multiple sclerosisMakoto Hirotani
Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
J Neuroimmunol 221:95-100. 2010..Our results indicate that TLR9-mediated IL-10 production by B cells was significantly decreased in MS, and this decrease is likely due to decreased TLR9 expression in memory B cells, suggesting a role of TLR9 in immunoregulation in MS... - Cystatin C in cerebrospinal fluid as a biomarker of ALSSachiko Tsuji-Akimoto
Department of Neurology, Graduate School of Medicine, Hokkaido University, Sapporo City, Hokkaido, Japan
Neurosci Lett 452:52-5. 2009..control subjects: p = 0.014 and ALS patients vs. polyneuropathy patients: p = 0.024). Cystatin C may be a useful biomarker of ALS and can be used to distinguish between ALS and polyneuropathy... - Intracranial hemorrhage in neuro-Behçet's syndromeSeiji Kikuchi
Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo
Intern Med 41:692-5. 2002..It is possible that the vascular pathologies caused by Behçet's syndrome and by cyclosporine conspire to induce CNS hemorrhaging in some cases... - MRI and pathological findings of rheumatoid meningitisMasaaki Matsushima
Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
J Clin Neurosci 17:129-32. 2010..RM is a treatable disease and in this patient RM was diagnosed on the basis of biopsy findings... - Vitamin D receptor gene polymorphism affects onset pattern of type 1 diabetesYoshiko Motohashi
Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
J Clin Endocrinol Metab 88:3137-40. 2003..Assessment of this VDR gene polymorphism may contribute to prediction of the onset pattern in individuals with a high risk of type 1 diabetes... - CTLA-4 gene polymorphism is not associated with conventional multiple sclerosis in JapaneseToshiyuki Fukazawa
Hokuyukai Neurology Hospital, Niju Yon Ken 2 2 4 30, Nishi ku, Sapporo 063 0802, Japan
J Neuroimmunol 159:225-9. 2005.... - [Susceptibility genes for multiple sclerosis]Toshiyuki Fukazawa
Hokuyukai Neurology Hospital
Nippon Rinsho 61:1311-6. 2003..Appropriate case ascertainment and collection as well as proper statistical method are needed to isolate the susceptibility genes for MS... - Baló's concentric sclerosislike lesion in the brainstem of a multiple sclerosis patientRichiro Kishimoto
J Neurol 255:760-1. 2008 - Attack-related severity: a key factor in understanding the spectrum of idiopathic inflammatory demyelinating disordersToshiyuki Fukazawa
Hokuyukai Neurology Hospital, Niju Yon Ken 2 2 4 30, Nishi ku, Sapporo 063 0802, Japan
J Neurol Sci 225:71-8. 2004..Attack-related severity may be an important factor if validated by prospective studies defining criteria and establishing relationships to disease course and treatment regimens... - Induction of antigen-specific tolerance in multiple sclerosis after immunization with DNA encoding myelin basic protein in a randomized, placebo-controlled phase 1/2 trialAmit Bar Or
Montreal Neurological Institute, Montreal, Quebec, Canada
Arch Neurol 64:1407-15. 2007..To assess safety and immune modulation by BHT-3009, a tolerizing DNA vaccine encoding full-length human myelin basic protein, in patients with multiple sclerosis (MS)... - Altered CD4+/CD8+ T-cell ratios in cerebrospinal fluid of natalizumab-treated patients with multiple sclerosisOlaf Stuve
Department of Neurology, University of Texas Southwestern Medical Center at Dallas, USA
Arch Neurol 63:1383-7. 2006.... - Natalizumab effects on immune cell responses in multiple sclerosisMasaaki Niino
Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Quebec, Canada
Ann Neurol 59:748-54. 2006..Monitoring these parameters could be relevant to ongoing safety and efficacy considerations... - Multiphasic demyelinating disorder with acute transverse myelitis in JapaneseToshiyuki Fukazawa
J Neurol 250:624-6. 2003 - Subacute syphilitic meningomyelitis with characteristic spinal MRI findingsSeiji Kikuchi
J Neurol 250:106-7. 2003 - Distinct effector cytokine profiles of memory and naive human B cell subsets and implication in multiple sclerosisMartin Duddy
Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, and Department of Neurology, Ottawa General Hospital, Canada
J Immunol 178:6092-9. 2007..Our findings are of particular relevance at a time when B cell directed therapies are being applied to clinical trials of several autoimmune diseases...