K Natsuga

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. doi request reprint Antibodies to pathogenic epitopes on type XVII collagen cause skin fragility in a complement-dependent and -independent manner
    Ken Natsuga
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo 0608638, Japan
    J Immunol 188:5792-9. 2012
  2. ncbi request reprint Consequences of two different amino-acid substitutions at the same codon in KRT14 indicate definitive roles of structural distortion in epidermolysis bullosa simplex pathogenesis
    Ken Natsuga
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Invest Dermatol 131:1869-76. 2011
  3. doi request reprint Malignant skin tumours in patients with inherited ichthyosis
    K Natsuga
    Department of Dermatology, Hokkaido University Graduate School of Medicine, North 15 West 7, Sapporo 060 8638, Japan
    Br J Dermatol 165:263-8. 2011
  4. doi request reprint Expression of exon-8-skipped kindlin-1 does not compensate for defects of Kindler syndrome
    Ken Natsuga
    Department of Dermatology, Hokkaido University Graduate School of Medicine, North 15 West 7, Sapporo, Japan
    J Dermatol Sci 61:38-44. 2011
  5. pmc Plectin deficiency leads to both muscular dystrophy and pyloric atresia in epidermolysis bullosa simplex
    Ken Natsuga
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Hum Mutat 31:E1687-98. 2010
  6. doi request reprint Response of intractable skin ulcers in recessive dystrophic epidermolysis bullosa patients to an allogeneic cultured dermal substitute
    Ken Natsuga
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Acta Derm Venereol 90:165-9. 2010
  7. doi request reprint Animal models of epidermolysis bullosa
    Ken Natsuga
    Department of Dermatology, Hokkaido University Graduate School of Medicine, North 15 West 7, Sapporo 060 8638, Japan
    Dermatol Clin 28:137-42. 2010
  8. doi request reprint Circulating IgA and IgE autoantibodies in antilaminin-332 mucous membrane pemphigoid
    K Natsuga
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Br J Dermatol 162:513-7. 2010
  9. ncbi request reprint Ultrastructural features of trafficking defects are pronounced in melanocytic nevus in Hermansky-Pudlak syndrome type 1
    Ken Natsuga
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Invest Dermatol 125:154-8. 2005
  10. ncbi request reprint Amicrobial pustulosis associated with IgA nephropathy and Sjögren's syndrome
    Ken Natsuga
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Am Acad Dermatol 57:523-6. 2007

Detail Information

Publications25

  1. doi request reprint Antibodies to pathogenic epitopes on type XVII collagen cause skin fragility in a complement-dependent and -independent manner
    Ken Natsuga
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo 0608638, Japan
    J Immunol 188:5792-9. 2012
    ..In summary, this study reveals the importance of Abs directed against distinct epitopes on COL17, which induce skin fragility in complement-dependent as well as complement-independent ways...
  2. ncbi request reprint Consequences of two different amino-acid substitutions at the same codon in KRT14 indicate definitive roles of structural distortion in epidermolysis bullosa simplex pathogenesis
    Ken Natsuga
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Invest Dermatol 131:1869-76. 2011
    ..Ala413Thr. These results show that changes in two distinct amino acids at a locus are destined to elicit different phenotypes due to the degree of structural distortion resulting from the amino-acid alterations...
  3. doi request reprint Malignant skin tumours in patients with inherited ichthyosis
    K Natsuga
    Department of Dermatology, Hokkaido University Graduate School of Medicine, North 15 West 7, Sapporo 060 8638, Japan
    Br J Dermatol 165:263-8. 2011
    ..As patients with these particular subtypes of ichthyosis seem to be prone to skin malignancies, including SCC, at an unusually young age, routine cancer surveillance of these patients is strongly recommended...
  4. doi request reprint Expression of exon-8-skipped kindlin-1 does not compensate for defects of Kindler syndrome
    Ken Natsuga
    Department of Dermatology, Hokkaido University Graduate School of Medicine, North 15 West 7, Sapporo, Japan
    J Dermatol Sci 61:38-44. 2011
    ..Mutations in KIND1, which encodes kindlin-1, are responsible for KS. c.1089del/1089+1del is a recurrent splice-site deletion mutation in KS patients...
  5. pmc Plectin deficiency leads to both muscular dystrophy and pyloric atresia in epidermolysis bullosa simplex
    Ken Natsuga
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Hum Mutat 31:E1687-98. 2010
    ..This study demonstrates that plectin deficiency can indeed lead to both muscular dystrophy and pyloric atresia in an individual EBS patient...
  6. doi request reprint Response of intractable skin ulcers in recessive dystrophic epidermolysis bullosa patients to an allogeneic cultured dermal substitute
    Ken Natsuga
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Acta Derm Venereol 90:165-9. 2010
    ..In conclusion, CDS is a promising modality for treatment of intractable skin ulcers in patients with RDEB, even though it does not appear to increase COL7 expression...
  7. doi request reprint Animal models of epidermolysis bullosa
    Ken Natsuga
    Department of Dermatology, Hokkaido University Graduate School of Medicine, North 15 West 7, Sapporo 060 8638, Japan
    Dermatol Clin 28:137-42. 2010
    ..After the discovery of the causative genes responsible for each EB subtype, many researchers have tried to develop EB animal models by genetically manipulating the corresponding genes...
  8. doi request reprint Circulating IgA and IgE autoantibodies in antilaminin-332 mucous membrane pemphigoid
    K Natsuga
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Br J Dermatol 162:513-7. 2010
    ..IgG autoantibodies against laminin-332 in patients with MMP are well documented; however, IgA and IgE autoantibodies against laminin-332 have not yet been described...
  9. ncbi request reprint Ultrastructural features of trafficking defects are pronounced in melanocytic nevus in Hermansky-Pudlak syndrome type 1
    Ken Natsuga
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Invest Dermatol 125:154-8. 2005
    ..Thus, ultrastructural analysis of nevus cells may be an additional diagnostic tool for HPS1 and could give us important clues to further understanding of the pathomechanisms of HPS...
  10. ncbi request reprint Amicrobial pustulosis associated with IgA nephropathy and Sjögren's syndrome
    Ken Natsuga
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Am Acad Dermatol 57:523-6. 2007
    ..The patient suffered from IgA nephropathy and Sjögren's syndrome. Skin symptoms were alleviated dramatically after corticosteroid pulse therapy and tonsillectomy...
  11. ncbi request reprint Non-Hodgkin lymphoma preceded by recalcitrant eczema
    Ken Natsuga
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Eur J Haematol 79:369-70. 2007
  12. doi request reprint Mucous membrane pemphigoid with generalized blisters: IgA and IgG autoantibodies target both laminin-332 and type XVII collagen
    I Hayashi
    Department of Dermatology, Sapporo City General Hospital, Sapporo, Japan
    Br J Dermatol 166:1116-20. 2012
    ..This is the first MMP case with circulating IgA and IgG autoantibodies against both laminin-332 and COL17...
  13. doi request reprint Cutaneous pemphigus vulgaris with skin features similar to the classic mucocutaneous type: a case report and review of the literature
    S Shinkuma
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Clin Exp Dermatol 33:724-8. 2008
    ....
  14. ncbi request reprint Two cases of atypical melanocytic lesions in recessive dystrophic epidermolysis bullosa infants
    K Natsuga
    Department of Dermatology, Hokkaido University Graduate School of Medicine, and Department of Dermatology, Sapporo City General Hospital, Sapporo, Japan
    Clin Exp Dermatol 30:636-9. 2005
    ..AtML may easily be misdiagnosed as malignant melanoma and, even in infant patients with RDEB, this should be included as one of the differential diagnosis of pigmented lesions...
  15. doi request reprint Usefulness of thermography techniques for evaluating the disease activity in Kimura's disease
    S Shinkuma
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Clin Exp Dermatol 33:768-71. 2008
    ..Kimura's disease (KD) is a rare, chronic inflammatory disorder predominantly affecting the head and neck. A case of KD in a 30-year-old man is reported. Thermography was useful for evaluating the activity of the condition...
  16. doi request reprint A novel humanized neonatal autoimmune blistering skin disease model induced by maternally transferred antibodies
    Wataru Nishie
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Immunol 183:4088-93. 2009
    ..Maternal transfer of pathogenic Abs to humanized neonatal mice is a unique and potential experimental system to establish a novel autoimmune disease model...
  17. pmc Type XVII collagen is a key player in tooth enamel formation
    Takuya Asaka
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Am J Pathol 174:91-100. 2009
    ..In conclusion, COL17 deficiency disrupts the epithelial-mesenchymal interactions, leading to both defective ameloblast differentiation and enamel malformation...
  18. pmc Keratinocyte-/fibroblast-targeted rescue of Col7a1-disrupted mice and generation of an exact dystrophic epidermolysis bullosa model using a human COL7A1 mutation
    Kei Ito
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Am J Pathol 175:2508-17. 2009
    ..This model has great potential for future research into the pathomechanisms of dystrophic epidermolysis bullosa and the development of gene therapies for patients with dystrophic epidermolysis bullosa...
  19. pmc Bone marrow transplantation restores epidermal basement membrane protein expression and rescues epidermolysis bullosa model mice
    Yasuyuki Fujita
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Proc Natl Acad Sci U S A 107:14345-50. 2010
    ..The current conventional BMT techniques have significant potential as a systemic therapeutic approach for the treatment of human EB...
  20. ncbi request reprint Leukaemic dissemination of Merkel cell carcinoma in a patient with systemic lupus erythematosus
    I Nemoto
    Department of Dermatology, Sapporo Social Insurance General Hospital, Sapporo, Japan
    Clin Exp Dermatol 33:270-2. 2008
    ..The high incidence of MCC in immunosuppressed patients such as those with SLE has been discussed previously. We consider that immunosuppression might be associated with bone-marrow metastasis, which is a rare form of MCC...
  21. doi request reprint Plectin expression patterns determine two distinct subtypes of epidermolysis bullosa simplex
    Ken Natsuga
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Hum Mutat 31:308-16. 2010
    ..These results also clearly account for the majority of EBS-MD PLEC1 mutation restriction within the large exon 31 that encodes the plectin rod domain, whereas EBS-PA PLEC1 mutations are generally outside exon 31...
  22. doi request reprint Epidermolysis bullosa in Japan
    Satoru Shinkuma
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Dermatol Clin 28:431-2, xvi. 2010
    ..This article discusses the prevalence among and genetic studies of Japanese patients with EB...
  23. ncbi request reprint Mycosis fungoides bullosa
    Ken Natsuga
    Arch Dermatol 142:793-5. 2006
  24. ncbi request reprint Novel ABCA12 mutations identified in two cases of non-bullous congenital ichthyosiform erythroderma associated with multiple skin malignant neoplasia
    Ken Natsuga
    J Invest Dermatol 127:2669-73. 2007
  25. ncbi request reprint Keratoacanthoma developing on nevus sebaceous in a child
    Hideyuki Ujiie
    J Am Acad Dermatol 56:S57-8. 2007