Affiliation: Hokkaido University
Matsumoto M, Funami K, Tatematsu M, Azuma M, Seya T. Assessment of the Toll-like receptor 3 pathway in endosomal signaling. Methods Enzymol. 2014;535:149-65 pubmed publisher
..Making a distinction between TLR3-mediated endosomal signaling and RLR-mediated signaling is key to understanding the role of these receptors in innate immunity. ..
Nakai M, Oshiumi H, Funami K, Okamoto M, Matsumoto M, Seya T, et al
. Interferon (IFN) and Cellular Immune Response Evoked in RNA-Pattern Sensing During Infection with Hepatitis C Virus (HCV). Sensors (Basel). 2015;15:27160-73 pubmed publisher
..Here we summarize our view on the mechanism by which DCs mature to induce NK and CTL in a status of HCV infection. ..
Takaki H, Takashima K, Oshiumi H, Ainai A, Suzuki T, Hasegawa H, et al
. cGAMP Promotes Germinal Center Formation and Production of IgA in Nasal-Associated Lymphoid Tissue. Med Sci (Basel). 2017;5: pubmed publisher
..The cGAMP effect was STING-dependent. Taken together, cGAMP as an HA vaccine adjuvant promoted a STING-dependent NALT environment suitable for the enhancement of IgA production. ..
Matsumoto M, Seya T. TLR3: interferon induction by double-stranded RNA including poly(I:C). Adv Drug Deliv Rev. 2008;60:805-12 pubmed publisher
..In this review, we summarize the current knowledge on TLR3 and discuss its possible role in innate and adaptive immunity. ..
Ishii N, Funami K, Tatematsu M, Seya T, Matsumoto M. Endosomal localization of TLR8 confers distinctive proteolytic processing on human myeloid cells. J Immunol. 2014;193:5118-28 pubmed publisher
..Hence, localization sites of the receptors are crucial for the nucleic acid-sensing mode and downstream signaling. ..
Tatematsu M, Funami K, Ishii N, Seya T, Obuse C, Matsumoto M. LRRC59 Regulates Trafficking of Nucleic Acid-Sensing TLRs from the Endoplasmic Reticulum via Association with UNC93B1. J Immunol. 2015;195:4933-42 pubmed publisher
..These findings help us understand how NA-sensing TLRs control their proper distribution in the infection/inflammatory state. ..
Tatematsu M, Yoshida R, Morioka Y, Ishii N, Funami K, Watanabe A, et al
. Raftlin Controls Lipopolysaccharide-Induced TLR4 Internalization and TICAM-1 Signaling in a Cell Type-Specific Manner. J Immunol. 2016;196:3865-76 pubmed publisher
..Thus, Raftlin appears to modulate cargo selection as an accessary protein of clathrin-associated adaptor protein-2 in clathrin-mediated endocytosis of TLR3/4 ligands. ..
Takeda Y, Kataoka K, Yamagishi J, Ogawa S, Seya T, Matsumoto M. A TLR3-Specific Adjuvant Relieves Innate Resistance to PD-L1 Blockade without Cytokine Toxicity in Tumor Vaccine Immunotherapy. Cell Rep. 2017;19:1874-1887 pubmed publisher
Leong C, Oshiumi H, Suzuki T, Matsumoto M, Seya T. Nucleic Acid Sensors Involved in the Recognition of HBV in the Liver-Specific in vivo Transfection Mouse Models-Pattern Recognition Receptors and Sensors for HBV. Med Sci (Basel). 2015;3:16-24 pubmed publisher
..This review will present the current understanding of innate immunity in HBV infection and of the challenges for clearing of the HBV infection. ..