I Kusumi

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. doi request reprint Effect of olanzapine orally disintegrating tablet versus oral standard tablet on body weight in patients with schizophrenia: a randomized open-label trial
    Ichiro Kusumi
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 36:313-7. 2012
  2. ncbi request reprint Lack of association between XBP1 genotype and calcium signaling in the platelets of healthy subjects
    Ichiro Kusumi
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo 060 8638, Japan
    Neurosci Lett 369:1-3. 2004
  3. ncbi request reprint Relationship between XBP1 genotype and personality traits assessed by TCI and NEO-FFI
    Ichiro Kusumi
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo, Hokkaido 060 8638, Japan
    Neurosci Lett 391:7-10. 2005
  4. ncbi request reprint Serotonin 5-HT(2A) receptor gene polymorphism, 5-HT(2A) receptor function and personality traits in healthy subjects: a negative study
    Ichiro Kusumi
    Department of Psychiatry, Hokkaido University School of Medicine, North 15, West 7, Sapporo 060 8638, Japan
    J Affect Disord 68:235-41. 2002
  5. doi request reprint Risperidone oral solution versus standard tablets for the acute treatment of patients with schizophrenia
    Ichiro Kusumi
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:537-40. 2011
  6. ncbi request reprint Long-term perospirone treatment with a single dose at bedtime in schizophrenia: relevant to intermittent dopamine D2 receptor antagonism
    Ichiro Kusumi
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo 060 8638, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:520-2. 2008
  7. doi request reprint Screening for diabetes using Japanese monitoring guidance in schizophrenia patients treated with second-generation antipsychotics: a cross-sectional study using baseline data
    Ichiro Kusumi
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Psychiatry Clin Neurosci 65:349-55. 2011
  8. doi request reprint Screening for diabetes using monitoring guidance in schizophrenia patients treated with second-generation antipsychotics: a 1-year follow-up study
    Ichiro Kusumi
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:1922-6. 2011
  9. ncbi request reprint Differential effects of subchronic treatments with atypical antipsychotic drugs on dopamine D2 and serotonin 5-HT2A receptors in the rat brain
    I Kusumi
    Department of Psychiatry, Hokkaido University School of Medicine, Sapporo, Japan
    J Neural Transm 107:295-302. 2000
  10. ncbi request reprint Effects of citalopram on dopamine D2 receptor expression in the rat brain striatum
    K Kameda
    Department of Psychiatry, Hokkaido University School of Medicine, Sapporo, Japan
    J Mol Neurosci 14:77-86. 2000

Collaborators

Detail Information

Publications41

  1. doi request reprint Effect of olanzapine orally disintegrating tablet versus oral standard tablet on body weight in patients with schizophrenia: a randomized open-label trial
    Ichiro Kusumi
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 36:313-7. 2012
    ..Previous reports describing that olanzapine ODT induced less weight gain than OST were not supported by results of this randomized study...
  2. ncbi request reprint Lack of association between XBP1 genotype and calcium signaling in the platelets of healthy subjects
    Ichiro Kusumi
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo 060 8638, Japan
    Neurosci Lett 369:1-3. 2004
    ..Further investigations are necessary to examine the relationship in the different peripheral blood cells and/or in larger samples from patients with bipolar disorder...
  3. ncbi request reprint Relationship between XBP1 genotype and personality traits assessed by TCI and NEO-FFI
    Ichiro Kusumi
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo, Hokkaido 060 8638, Japan
    Neurosci Lett 391:7-10. 2005
    ..Further investigations are necessary to examine the relationship in patients with bipolar disorder, or use full version of various self-rating personality assessments...
  4. ncbi request reprint Serotonin 5-HT(2A) receptor gene polymorphism, 5-HT(2A) receptor function and personality traits in healthy subjects: a negative study
    Ichiro Kusumi
    Department of Psychiatry, Hokkaido University School of Medicine, North 15, West 7, Sapporo 060 8638, Japan
    J Affect Disord 68:235-41. 2002
    ..We therefore examined the relationship between personality traits, the 5-HT(2A) receptor function, and 5-HT(2A) receptor gene polymorphisms...
  5. doi request reprint Risperidone oral solution versus standard tablets for the acute treatment of patients with schizophrenia
    Ichiro Kusumi
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:537-40. 2011
    ..Subsequent studies should carefully establish the differences among various forms of antipsychotic drugs...
  6. ncbi request reprint Long-term perospirone treatment with a single dose at bedtime in schizophrenia: relevant to intermittent dopamine D2 receptor antagonism
    Ichiro Kusumi
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo 060 8638, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:520-2. 2008
    ....
  7. doi request reprint Screening for diabetes using Japanese monitoring guidance in schizophrenia patients treated with second-generation antipsychotics: a cross-sectional study using baseline data
    Ichiro Kusumi
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Psychiatry Clin Neurosci 65:349-55. 2011
    ....
  8. doi request reprint Screening for diabetes using monitoring guidance in schizophrenia patients treated with second-generation antipsychotics: a 1-year follow-up study
    Ichiro Kusumi
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:1922-6. 2011
    ..Not only cross-sectional baseline screening but also longitudinal follow-up screening is important to detect glucose abnormalities in patients treated with SGAs...
  9. ncbi request reprint Differential effects of subchronic treatments with atypical antipsychotic drugs on dopamine D2 and serotonin 5-HT2A receptors in the rat brain
    I Kusumi
    Department of Psychiatry, Hokkaido University School of Medicine, Sapporo, Japan
    J Neural Transm 107:295-302. 2000
    ....
  10. ncbi request reprint Effects of citalopram on dopamine D2 receptor expression in the rat brain striatum
    K Kameda
    Department of Psychiatry, Hokkaido University School of Medicine, Sapporo, Japan
    J Mol Neurosci 14:77-86. 2000
    ....
  11. ncbi request reprint Effects of lithium on dopamine D2 receptor expression in the rat brain striatum
    K Kameda
    Department of Psychiatry, Hokkaido University School of Medicine, Sapporo, Japan
    J Neural Transm 108:321-34. 2001
    ....
  12. pmc In vivo occupation of dopamine D1, D2 and serotonin (5-HT)2A receptors by sertindole in the rat brain
    Y Takahashi
    Department of Psychiatry, Hokkaido University School of Medicine, Sapporo, Japan
    J Psychiatry Neurosci 23:157-62. 1998
    ..To determine the in vivo occupation of dopamine D1, D2 and serotonin (5-HT)2A receptors by novel antipsychotic agent sertindole using N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ), an irreversible antagonist at these receptor sites...
  13. ncbi request reprint A possible association between the -116C/G single nucleotide polymorphism of the XBP1 gene and lithium prophylaxis in bipolar disorder
    Takuya Masui
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Int J Neuropsychopharmacol 9:83-8. 2006
    ..The association between the -116C/G polymorphism and clinical efficacy of mood stabilizers should be further investigated in a prospective study with a larger sample...
  14. ncbi request reprint Serotonin-induced platelet intracellular calcium mobilization in various psychiatric disorders: is it specific to bipolar disorder?
    K Suzuki
    Department of Psychiatry, Hokkaido University School of Medicine, North 15, West 7, 060 8638, Sapporo, Japan
    J Affect Disord 64:291-6. 2001
    ..It has not been ascertained whether this enhanced response is specific to some type of affective disorders among various mental disorders...
  15. ncbi request reprint Effects of calmodulin and protein kinase C modulators on transient Ca2+ increase and capacitative Ca2+ entry in human platelets: relevant to pathophysiology of bipolar disorder
    Tatsuyuki Akimoto
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15 West 7, Kita ku, Sapporo 060 8638, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:136-41. 2007
    ..However, this is a preliminary study using a small sample, thus further studies are needed to examine the PKC and calmodulin modulators on the capacitative Ca(2+) entry in a larger sample...
  16. pmc Effects of valproate on serotonin-induced intracellular calcium mobilization in human platelets
    Tatsuyuki Akimoto
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    J Psychiatry Neurosci 32:17-22. 2007
    ..In patients with bipolar disorder, 5-hydroxytryptamine (5-HT)-induced intraplatelet calcium (Ca) mobilization has been shown to be enhanced...
  17. ncbi request reprint Effects of acute citalopram treatment on the methamphetamine-induced locomotor activity
    K Kameda
    Department of Psychiatry, Hokkaido University School of Medicine, Sapporo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 25:1583-95. 2001
    ..Another mechanism through which the pretreatment with citalopram enhanced the methamphetamine-induced locomotor activity, such as the increased expression of the dopamine D2 receptors, could not be excluded...
  18. ncbi request reprint Tone duration mismatch negativity deficits predict impairment of executive function in schizophrenia
    Atsuhito Toyomaki
    Department of Psychiatry, Graduate School of Medicine, Hokkaido University N15, W7, Sapporo 060 8638, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:95-9. 2008
    ..Our finding suggests MMN deficits in schizophrenia predict deficits of executive function and might reflect ongoing functional abnormality of fronto-temporal interaction...
  19. ncbi request reprint A possible association between missense polymorphism of the breakpoint cluster region gene and lithium prophylaxis in bipolar disorder
    Takuya Masui
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo, 060 8638, Hokkaido, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:204-8. 2008
    ..We found that the allele frequency of Ser796 was significantly higher in non-responders than in responders. Further investigation is warranted to confirm our findings...
  20. ncbi request reprint Effects of lithium on brain glucose metabolism in healthy men
    Tomoya Kohno
    Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, N 15 W 7 Kita ku, Sapporo, Japan
    J Clin Psychopharmacol 27:698-702. 2007
    ....
  21. ncbi request reprint Left temporal perfusion associated with suspiciousness score on the Brief Psychiatric Rating Scale in schizophrenia
    Tomoya Kohno
    Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    Psychiatry Res 147:163-71. 2006
    ..This analysis permits the quantitative assessment of the severity of persecutory delusions in relation to left temporal perfusion in patients with schizophrenia...
  22. ncbi request reprint Long-term outcome of antidepressant-refractory depression: the relevance of unrecognized bipolarity
    Takeshi Inoue
    Department of Psychiatry, Neural Function Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    J Affect Disord 95:61-7. 2006
    ..Therefore, the present study investigated the long-term outcome of 26 antidepressant-refractory patients with depression, whom we had studied and treated in 1995...
  23. ncbi request reprint Effect of carbamazepine on the single oral dose pharmacokinetics of perospirone and its active metabolite
    Takuya Masui
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo, Hokkaido, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:1330-3. 2006
    ..This study provided an in vivo evidence of involvement of CYP3A4 in the metabolism of perospirone...
  24. ncbi request reprint Effects of lithium and valproate on agonist-induced platelet intracellular calcium mobilization: relevance to myosin light chain kinase
    Katsuji Suzuki
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo 060 8638, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 28:67-72. 2004
    ..These results suggest that the enhanced Ca response observed in bipolar disorder might be relevant to decreased function of MLCK and that the mechanism of action of lithium may include a compensatory effect on MLCK modulation...
  25. ncbi request reprint Efficacy of carbamazepine against neuroleptic-induced akathisia in treatment with perospirone: case series
    Takuya Masui
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo, Hokkaido 060 8638, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 29:343-6. 2005
    ..Further investigations including the monitoring pharmacokinetics of perospirone and ID-15036 under concomitant use of carbamazepine should be carried out to explain the mechanism of the current experience...
  26. ncbi request reprint Altered 5-HT-induced calcium response in the presence of staurosporine in blood platelets from bipolar disorder patients
    Katsuji Suzuki
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Japan
    Neuropsychopharmacology 28:1210-4. 2003
    ..Moreover, the trend of the Ca response towards staurosporine may become a specific biological marker for unipolar-bipolar dichotomy...
  27. ncbi request reprint Effects of itraconazole and tandospirone on the pharmacokinetics of perospirone
    Takuya Masui
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Ther Drug Monit 28:73-5. 2006
    ..The metabolism of perospirone was significantly inhibited by treatment with itraconazole but not by tandospirone. The present study suggests that CYP3A4 is significantly involved in metabolism of perospirone in humans...
  28. ncbi request reprint Open pergolide treatment of tricyclic and heterocyclic antidepressant-resistant depression
    T Izumi
    Department of Psychiatry, Hokkaido University School of Medicine, North 15, West 7, Kita ku, 060 8638, Sapporo, Japan
    J Affect Disord 61:127-32. 2000
    ..Recently, a dopamine hypothesis of depression was put forward, and several studies have demonstrated that direct and indirect dopamine agonists have antidepressant effects...
  29. ncbi request reprint Glucose and lipid metabolism of long-term risperidone monotherapy in patients with schizophrenia
    Mari Murashita
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Psychiatry Clin Neurosci 61:54-8. 2007
    ..A high level of plasma ghrelin might increase appetite, leading to exacerbation of metabolic impairment...
  30. ncbi request reprint Nucleotide sequence analysis of the binding site on the inositol 1,4,5-trisphosphate type-1 receptor in bipolar disorder -- a negative study
    K Fujimaki
    Department of Psychiatry, Shiga University of Medical Science, Otsu, Japan
    J Affect Disord 65:139-43. 2001
    ..The nucleotide sequence in this region was preserved in all subjects. This finding suggests that IP(3)R1 dysfunction through the FKBP12 binding site is not involved in the pathogenesis of bipolar disorder...
  31. ncbi request reprint Relationship between plasma concentration levels of risperidone and clinical effects in the treatment of delirium
    Hiroyuki Toda
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Int Clin Psychopharmacol 20:331-3. 2005
    ..The plasma concentration level of risperidone at 30 min after the first 0.5 mg dose may be a favourable response predictor in the treatment of delirium. Further studies in larger samples are needed to verify this preliminary finding...
  32. ncbi request reprint Serotonin transporters
    Takeshi Inoue
    Department of Psychiatry, Hokkaido University, Graduate School of Medicine, Sapporo, Japan
    Curr Drug Targets CNS Neurol Disord 1:519-29. 2002
    ..This overview of recent studies of the serotonin transporters attempts to open new areas for discussion and define concepts not yet comprehensively reviewed...
  33. ncbi request reprint Olanzapine increases plasma ghrelin level in patients with schizophrenia
    Mari Murashita
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 14, West 7, Sapporo 060 8638, Japan
    Psychoneuroendocrinology 30:106-10. 2005
    ..To elucidate the mechanism of appetite and weight gain during olanzapine treatment, we investigated the circulating ghrelin levels...
  34. ncbi request reprint Acute administration of clozapine concurrently increases blood glucose and circulating plasma ghrelin levels in rats
    Mari Murashita
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Psychoneuroendocrinology 32:777-84. 2007
    ..The aim of this study was to determine the mechanism of clozapine-induced weight gain and hyperglycemia, and to clarify whether clozapine-induced hyperglycemia results from impairment of the system regulating appetite...
  35. ncbi request reprint A case of tardive dystonia successfully managed with quetiapine
    Yukiya Sasaki
    J Clin Psychiatry 65:583-4. 2004
  36. pmc Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p
    Tadao Arinami
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki Ken, 305 8577, Japan
    Am J Hum Genet 77:937-44. 2005
    ....
  37. ncbi request reprint Depressive patients are more impulsive and inconsistent in intertemporal choice behavior for monetary gain and loss than healthy subjects--an analysis based on Tsallis' statistics
    Taiki Takahashi
    Unit of Cognitive and Behavioral Sciences, Department of Life Sciences, School of Arts and Sciences, The University of Tokyo, Komaba, Tokyo, 153 8902, Japan
    Neuro Endocrinol Lett 29:351-8. 2008
    ..This examination is potentially important for advances in neuroeconomics of intertemporal choice, because depression is associated with reduced serotonergic activities in the brain...
  38. ncbi request reprint Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder
    Chihiro Kakiuchi
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Wako Shi, Saitama 351 0198, Japan
    Nat Genet 35:171-5. 2003
    ..These results indicate that the -116C-->G polymorphism in XBP1 causes an impairment of its positive feedback system and increases the risk of bipolar disorder...
  39. ncbi request reprint Time course of dopamine D2 receptor occupancy by clozapine with medium and high plasma concentrations
    Akihiro Takano
    Brain Imaging Project, National Institute of Radiological Sciences, 9 1 4 chome, Anagawa, Inage Ku, Chiba shi, Chiba 263 8555, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:75-81. 2006
    ..At high plasma concentration, clozapine can induce high extrastriatal dopamine D2 receptor occupancy in the human brain, and this finding fitted well with the theoretical estimation...
  40. ncbi request reprint Involvement of a polymorphism in the 5-HT2A receptor gene in impulsive behavior
    Michio Nomura
    Department of Psychology, Tokai Women s University, Nakakirino cho, Kakamigahara, Gifu 504 8511, Japan
    Psychopharmacology (Berl) 187:30-5. 2006
    ..In this study, we examined whether this 5-HT2A receptor gene polymorphism is involved in impulsive aggression by evaluating a behavioral task (go/no-go task) in normal volunteers...
  41. ncbi request reprint Lithium response and Val66Met polymorphism of the brain-derived neurotrophic factor gene in Japanese patients with bipolar disorder
    Takuya Masui
    Psychiatr Genet 16:49-50. 2006
    ..Our results suggested that the brain-derived neurotrophic factor Val66Met polymorphism might not greatly contribute to the efficacy of lithium in bipolar disorder...