Akemi Kosaka

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. ncbi request reprint The critical role of Th1-dominant immunity in tumor immunology
    T Nishimura
    Division of Immunoregulation, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Cancer Chemother Pharmacol 46:S52-61. 2000
  2. ncbi request reprint Potentiation of tumor eradication by adoptive immunotherapy with T-cell receptor gene-transduced T-helper type 1 cells
    Kenji Chamoto
    Division of Immunoregulation, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Cancer Res 64:386-90. 2004
  3. ncbi request reprint AsialoGM1+CD8+ central memory-type T cells in unimmunized mice as novel immunomodulator of IFN-gamma-dependent type 1 immunity
    Akemi Kosaka
    Division of Immunoregulation, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Sapporo 060 0815, Japan
    Int Immunol 19:249-56. 2007
  4. ncbi request reprint Critical role of the Th1/Tc1 circuit for the generation of tumor-specific CTL during tumor eradication in vivo by Th1-cell therapy
    Kenji Chamoto
    Division of Immunoregulation, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Sapporo 060 0815, Japan
    Cancer Sci 94:924-8. 2003
  5. ncbi request reprint NKT cells act as regulatory cells rather than killer cells during activation of NK cell-mediated cytotoxicity by alpha-galactosylceramide in vivo
    Kenji Chamoto
    Division of Immunoregulation, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, N 15, W 7, Sapporo 060 0815, Japan
    Immunol Lett 95:5-11. 2004
  6. ncbi request reprint An efficient method to prepare T cell receptor gene-transduced cytotoxic T lymphocytes type 1 applicable to tumor gene cell-therapy
    Takemasa Tsuji
    Division of Immunoregulation, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Kita ku, Sapporo 060 0815, Japan
    Cancer Sci 94:389-93. 2003
  7. ncbi request reprint Interleukin-12-responding asialoGM1+CD8+ central memory-type T cells as precursor cells for interferon-gamma-producing killer T cells
    Akemi Kosaka
    Division of Immunoregulation, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Cancer Sci 97:1236-41. 2006
  8. ncbi request reprint Unexpected role of TNF-alpha in graft versus host reaction (GVHR): donor-derived TNF-alpha suppresses GVHR via inhibition of IFN-gamma-dependent donor type-1 immunity
    Satoshi Yamamoto
    Division of Immunoregulation, Institute for Genetic Medicine, School of Medicine, Hokkaido University, Sapporo, Japan
    Int Immunol 16:811-7. 2004

Collaborators

Detail Information

Publications8

  1. ncbi request reprint The critical role of Th1-dominant immunity in tumor immunology
    T Nishimura
    Division of Immunoregulation, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Cancer Chemother Pharmacol 46:S52-61. 2000
    ....
  2. ncbi request reprint Potentiation of tumor eradication by adoptive immunotherapy with T-cell receptor gene-transduced T-helper type 1 cells
    Kenji Chamoto
    Division of Immunoregulation, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Cancer Res 64:386-90. 2004
    ..Thus, TCR-transduced Th1 cells are a promising alternative for the development of effective adoptive immunotherapies...
  3. ncbi request reprint AsialoGM1+CD8+ central memory-type T cells in unimmunized mice as novel immunomodulator of IFN-gamma-dependent type 1 immunity
    Akemi Kosaka
    Division of Immunoregulation, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Sapporo 060 0815, Japan
    Int Immunol 19:249-56. 2007
    ..Thus, ASGM1(+)CD8(+) T(CMT), whose differentiation in vivo is genetically controlled, appear to play a critical role in the control of type 1 immunity, which is essential for therapy of tumors and infectious diseases...
  4. ncbi request reprint Critical role of the Th1/Tc1 circuit for the generation of tumor-specific CTL during tumor eradication in vivo by Th1-cell therapy
    Kenji Chamoto
    Division of Immunoregulation, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Sapporo 060 0815, Japan
    Cancer Sci 94:924-8. 2003
    ..This finding indicated that adoptive chemoimmunotherapy using Th1 cells should be applicable as a novel tool to enhance the Th1/Tc1 circuit, which is beneficial for inducing tumor eradication in vivo...
  5. ncbi request reprint NKT cells act as regulatory cells rather than killer cells during activation of NK cell-mediated cytotoxicity by alpha-galactosylceramide in vivo
    Kenji Chamoto
    Division of Immunoregulation, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, N 15, W 7, Sapporo 060 0815, Japan
    Immunol Lett 95:5-11. 2004
    ..Thus, NK cells rather than NKT cells may be a crucial early activated killer induced by alpha-GalCer in vivo...
  6. ncbi request reprint An efficient method to prepare T cell receptor gene-transduced cytotoxic T lymphocytes type 1 applicable to tumor gene cell-therapy
    Takemasa Tsuji
    Division of Immunoregulation, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Kita ku, Sapporo 060 0815, Japan
    Cancer Sci 94:389-93. 2003
    ..Thus, we have developed an efficient method to induce TCR gene-modified antigen-specific Tc1 cells that exhibit antitumor activity both in vitro and in vivo...
  7. ncbi request reprint Interleukin-12-responding asialoGM1+CD8+ central memory-type T cells as precursor cells for interferon-gamma-producing killer T cells
    Akemi Kosaka
    Division of Immunoregulation, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Cancer Sci 97:1236-41. 2006
    ....
  8. ncbi request reprint Unexpected role of TNF-alpha in graft versus host reaction (GVHR): donor-derived TNF-alpha suppresses GVHR via inhibition of IFN-gamma-dependent donor type-1 immunity
    Satoshi Yamamoto
    Division of Immunoregulation, Institute for Genetic Medicine, School of Medicine, Hokkaido University, Sapporo, Japan
    Int Immunol 16:811-7. 2004
    ..Our findings demonstrate, for the first time, that donor-derived TNF-alpha suppress GVHR by inhibiting IFN-gamma-dependent donor type-1 immunity which is essential for host TNF-alpha elevation...