Research Topics
Genomes and Genes | Ichiro KinoshitaSummaryAffiliation: Hokkaido University Country: Japan Publications
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Detail Information
Publications
Clinical benefit of readministration of gefitinib for initial gefitinib-responders with non-small cell lung cancerHiroshi Yokouchi
First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan
BMC Cancer 7:51. 2007....
Expression of LGR5, an intestinal stem cell marker, during each stage of colorectal tumorigenesisKayoko Takeda
Department of Medical Oncology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
Anticancer Res 31:263-70. 2011..The Wnt target LGR5 has been recently identified as a murine intestinal stem cell marker. Its role during each stage of human colorectal tumorigenesis remains to be determined...- Clinicopathological significance of expression of p-c-Jun, TCF4 and beta-Catenin in colorectal tumorsKayoko Takeda
Department of Medical Oncology, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
BMC Cancer 8:328. 2008..To determine the significance of these three proteins in human colorectal tumors, we analyzed their nuclear expression by immunohistochemistry... - A Case of High-Grade Neuroendocrine Carcinoma That Improved with Bevacizumab plus Modified FOLFOX6 as the Fourth-Line ChemotherapySatoshi Takeuchi
Department of Medical Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Case Rep Oncol 4:260-6. 2011..Dramatic tumor shrinkage was obtained, and a partial response was achieved. This case suggests that high-grade neuroendocrine carcinoma can be treated with bevacizumab in combination with cytotoxic chemotherapy... - Non-responsiveness to gefitinib in a patient with lung adenocarcinoma having rare EGFR mutations S768I and V769LHajime Asahina
First Department of Medicine, Hokkaido University School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
Lung Cancer 54:419-22. 2006..Disease progressed during 6 weeks of treatment. This case suggests that in vitro sensitivity to gefitinib correlates with distinct clinical responsiveness to gefitinib in various types of EGFR mutations... 
Minichromosome maintenance (MCM) protein 4 as a marker for proliferation and its clinical and clinicopathological significance in non-small cell lung cancerJunko Kikuchi
First Department of Medicine, Hokkaido University School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
Lung Cancer 72:229-37. 2011....- Phase I study of concurrent real-time tumor-tracking thoracic radiation therapy with paclitaxel and carboplatin in locally advanced non-small cell lung cancerJun Sakakibara-Konishi
First Department of Medicine, Hokkaido University School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
Lung Cancer 74:248-52. 2011..This study was conducted to determine the maximum tolerated dose (MTD) and recommended dose (RD) of paclitaxel in combination with carboplatin and concurrent real-time tumor-tracking thoracic radiation therapy (thoracic RTRT)... - 18F-fluorothymidine PET/CT as an early predictor of tumor response to treatment with cetuximab in human lung cancer xenograftsSatoshi Takeuchi
Department of Medical Oncology, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido 060 8638, Japan
Oncol Rep 26:725-30. 2011..01). These results suggest that 18F-FLT-PET/CT can be a useful predictor to determine the response to molecular targeted drugs such as cetuximab at an earlier time point than the change of tumor size... - [Non-small-cell lung cancer]Hirotoshi Akita
Dept of Medical Oncology, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
Gan To Kagaku Ryoho 35:720-4. 2008..Multi-target tyrosine kinase inhibitors in combination with standard chemotherapy, and anti-EGFR antibodies and EGFR tyrosine kinase inhibitors in combination with thoracic radiotherapy, are under clinical trials... - Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cellsMasahisa Jinushi
Division of Signaling in Cancer and Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
Proc Natl Acad Sci U S A 108:12425-30. 2011..Thus, the pharmacological targeting of key factors derived from tumor-associated inflammation provides a unique strategy to eradicate therapy-resistant tumors by manipulating CSC activities... - Epithelioid sarcoma presenting as pulmonary cysts with cancer antigen 125 expressionEiki Kikuchi
First Department of Medicine, Hokkaido University Hospital and School of Medicine, Sapporo, Japan
Respirology 11:826-9. 2006..However, presence of cancer antigen 125 hindered obtaining a correct diagnosis of ES... - Establishment and characterization of amylase-producing lung adenocarcinoma cell line, IMEC-2Hiroshi Yokouchi
First Department of Medicine, Hokkaido University School of Medicine, North 15, West 7, Kita ku, Sapporo, Japan
Anticancer Res 26:2821-7. 2006..Few studies have successfully established an amylase-producing lung cancer cell line or have examined its cytological, biochemical and biological features... - E1AF/PEA3 activates the Rho/Rho-associated kinase pathway to increase the malignancy potential of non-small-cell lung cancer cellsNobuyuki Hakuma
First Department of Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Cancer Res 65:10776-82. 2005..These results suggest that E1AF activates the Rho/ROCK pathway in an HGF-enhanced manner and its activation is important in E1AF-induced motility and invasion as well as tumorigenesis and metastasis in NSCLC cells... - Retinoic acid inhibits interleukin-4-induced eotaxin production in a human bronchial epithelial cell lineKei Takamura
1st Dept. of Medicine, Hokkaido Univ. School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan
Am J Physiol Lung Cell Mol Physiol 286:L777-85. 2004..These findings raise the possibility that RA may reduce eosinophilic airway inflammation, one of the prominent pathological features of allergic diseases such as bronchial asthma... - [Superior vena cava syndrome]Jun Taguchi
Dept of Medical Oncology, Hokkaido University Graduate School of Medicine, Japan
Gan To Kagaku Ryoho 38:518-23. 2011..The presence of the SVC syndrome does not reduce the likelihood ofa cure for the underlying malignant condition, and should not compromise the choice of appropriate therapy... - Expression of N-acetylglucosaminyltransferase V in the development of human esophageal cancers: immunohistochemical data from carcinomas and nearby noncancerous lesionsYoko Ishibashi
Department of Medical Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Oncology 69:301-10. 2005..005). GnT-V expression was frequently observed in SCCs of small size and without distant metastasis or lymph node metastasis. CONCLUSIONS: Increased expression of GnT-V is associated with the early event of esophageal tumorigenesis... - ATM-mediated DNA damage signals mediate immune escape through integrin-αvβ3-dependent mechanismsMasahisa Jinushi
Research Center for Infection Associated Cancer, Institute for Genetic Medicine, Hokkaido University, Tokyo, Japan
Cancer Res 72:56-65. 2012..Furthermore, these findings suggest that integrin-αvβ3 targeting may benefit patients' refractory to current anticancer regimens by defeating DNA damage signaling-induced immune escape...