Kikuchi S, Fukazawa T, Niino M, Yabe I, Miyagishi R, Hamada T, et al. HLA-related subpopulations of MS in Japanese with and without oligoclonal IgG bands. Human leukocyte antigen. Neurology. 2003;60:647-51 pubmed
..MS is heterogeneous in its association with HLA alleles, and based on the immunogenetic differences, the MS patients in this population include at least two HLA-related subpopulations with and without OCB. ..
Kikuchi S, Fukazawa T, Niino M, Yabe I, Miyagishi R, Hamada T, et al. Estrogen receptor gene polymorphism and multiple sclerosis in Japanese patients: interaction with HLA-DRB1*1501 and disease modulation. J Neuroimmunol. 2002;128:77-81 pubmed
..The [P] allele-positive patients with disease duration of more than 5 years had a significantly higher progression index (PI) of disability (p=0.0230) and a worse ranked MS severity score (p=0.0152) than their non-[P] counterparts. ..