- Kikuchi S, Fukazawa T, Niino M, Yabe I, Miyagishi R, Hamada T, et al. HLA-related subpopulations of MS in Japanese with and without oligoclonal IgG bands. Human leukocyte antigen. Neurology. 2003;60:647-51 pubmed..MS is heterogeneous in its association with HLA alleles, and based on the immunogenetic differences, the MS patients in this population include at least two HLA-related subpopulations with and without OCB. ..
- Kikuchi S, Fukazawa T, Niino M, Yabe I, Miyagishi R, Hamada T, et al. Estrogen receptor gene polymorphism and multiple sclerosis in Japanese patients: interaction with HLA-DRB1*1501 and disease modulation. J Neuroimmunol. 2002;128:77-81 pubmed..The [P] allele-positive patients with disease duration of more than 5 years had a significantly higher progression index (PI) of disability (p=0.0230) and a worse ranked MS severity score (p=0.0152) than their non-[P] counterparts. ..