Seiji Kikuchi

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. ncbi request reprint Neurotoxicity of methylglyoxal and 3-deoxyglucosone on cultured cortical neurons: synergism between glycation and oxidative stress, possibly involved in neurodegenerative diseases
    S Kikuchi
    Department of Neurology, Hokkaido University School of Medicine, Sapporo, Hokkaido, Japan
    J Neurosci Res 57:280-9. 1999
  2. ncbi request reprint Prostaglandin E1 protects cultured spinal neurons against the effects of nitric oxide toxicity
    S Kikuchi
    Department of Neurology, Hokkaido University School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Neuropharmacology 42:714-23. 2002
  3. ncbi request reprint Estrogen receptor gene polymorphism and multiple sclerosis in Japanese patients: interaction with HLA-DRB1*1501 and disease modulation
    Seiji Kikuchi
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nshi 7, Kita ku, Sapporo 060 8638, Japan
    J Neuroimmunol 128:77-81. 2002
  4. ncbi request reprint HLA-related subpopulations of MS in Japanese with and without oligoclonal IgG bands. Human leukocyte antigen
    S Kikuchi
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Neurology 60:647-51. 2003
  5. ncbi request reprint Glycation--a sweet tempter for neuronal death
    Seiji Kikuchi
    Department of Neurology, Hokkaido University School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo, Japan
    Brain Res Brain Res Rev 41:306-23. 2003
  6. ncbi request reprint Effect of proteasome inhibitor on cultured mesencephalic dopaminergic neurons
    Seiji Kikuchi
    Department of Neurology, Hokkaido University School of Medicine, Kita 15, Nishi 7, Kita ku, Hokkaido, Sapporo, Japan
    Brain Res 964:228-36. 2003
  7. ncbi request reprint Detection of an Amadori product, 1-hexitol-lysine, in the anterior horn of the amyotrophic lateral sclerosis and spinobulbar muscular atrophy spinal cord: evidence for early involvement of glycation in motoneuron diseases
    S Kikuchi
    Department of Neurology, Hokkaido University School of Medicine, Sapporo, Japan
    Acta Neuropathol 99:63-6. 2000
  8. ncbi request reprint Effect of geranylgeranylaceton on cellular damage induced by proteasome inhibition in cultured spinal neurons
    Seiji Kikuchi
    Department of Neurology, Hokkaido University School of Medicine, Sapporo, Japan
    J Neurosci Res 69:373-81. 2002
  9. ncbi request reprint Brefeldin A-induced neurotoxicity in cultured spinal cord neurons
    Seiji Kikuchi
    Department of Neurology, Hokkaido University School of Medicine, Sapporo, Hokkaido, Japan
    J Neurosci Res 71:591-9. 2003
  10. ncbi request reprint Detection of N epsilon-(carboxymethyl)lysine (CML) and non-CML advanced glycation end-products in the anterior horn of amyotrophic lateral sclerosis spinal cord
    Seiji Kikuchi
    Department of Neurology, Hokkaido University School of Medicine, Sapporo, Japan
    Amyotroph Lateral Scler Other Motor Neuron Disord 3:63-8. 2002

Detail Information

Publications115 found, 100 shown here

  1. ncbi request reprint Neurotoxicity of methylglyoxal and 3-deoxyglucosone on cultured cortical neurons: synergism between glycation and oxidative stress, possibly involved in neurodegenerative diseases
    S Kikuchi
    Department of Neurology, Hokkaido University School of Medicine, Sapporo, Hokkaido, Japan
    J Neurosci Res 57:280-9. 1999
    ....
  2. ncbi request reprint Prostaglandin E1 protects cultured spinal neurons against the effects of nitric oxide toxicity
    S Kikuchi
    Department of Neurology, Hokkaido University School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Neuropharmacology 42:714-23. 2002
    ..Our data indicate that PGE(1) exerts a protective action against NO neurotoxicity in cultured spinal neurons, and suggests a therapeutic potential of PGE(1) against spinal cord disease, such as amyotrophic lateral sclerosis...
  3. ncbi request reprint Estrogen receptor gene polymorphism and multiple sclerosis in Japanese patients: interaction with HLA-DRB1*1501 and disease modulation
    Seiji Kikuchi
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nshi 7, Kita ku, Sapporo 060 8638, Japan
    J Neuroimmunol 128:77-81. 2002
    ..0001). The [P] allele-positive patients with disease duration of more than 5 years had a significantly higher progression index (PI) of disability (p=0.0230) and a worse ranked MS severity score (p=0.0152) than their non-[P] counterparts...
  4. ncbi request reprint HLA-related subpopulations of MS in Japanese with and without oligoclonal IgG bands. Human leukocyte antigen
    S Kikuchi
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Neurology 60:647-51. 2003
    ....
  5. ncbi request reprint Glycation--a sweet tempter for neuronal death
    Seiji Kikuchi
    Department of Neurology, Hokkaido University School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo, Japan
    Brain Res Brain Res Rev 41:306-23. 2003
    ..We speculate on the presence of synergism between glycation and oxidative stress. In this review, we provide an outline of glycation and propose some possible mechanisms of its cytotoxicity and defense systems against it...
  6. ncbi request reprint Effect of proteasome inhibitor on cultured mesencephalic dopaminergic neurons
    Seiji Kikuchi
    Department of Neurology, Hokkaido University School of Medicine, Kita 15, Nishi 7, Kita ku, Hokkaido, Sapporo, Japan
    Brain Res 964:228-36. 2003
    ..Our results suggest that proteasome inhibition causes the neurotoxicity in mesencephalic neurons, but that is not sufficient to reproduce the selective damage to dopaminergic neurons, such as that seen in PD...
  7. ncbi request reprint Detection of an Amadori product, 1-hexitol-lysine, in the anterior horn of the amyotrophic lateral sclerosis and spinobulbar muscular atrophy spinal cord: evidence for early involvement of glycation in motoneuron diseases
    S Kikuchi
    Department of Neurology, Hokkaido University School of Medicine, Sapporo, Japan
    Acta Neuropathol 99:63-6. 2000
    ..Furthermore, Amadori product was undetectable in the tissues from age-matched controls. Thus, 1-HL formation could not reflect physiological aging...
  8. ncbi request reprint Effect of geranylgeranylaceton on cellular damage induced by proteasome inhibition in cultured spinal neurons
    Seiji Kikuchi
    Department of Neurology, Hokkaido University School of Medicine, Sapporo, Japan
    J Neurosci Res 69:373-81. 2002
    ....
  9. ncbi request reprint Brefeldin A-induced neurotoxicity in cultured spinal cord neurons
    Seiji Kikuchi
    Department of Neurology, Hokkaido University School of Medicine, Sapporo, Hokkaido, Japan
    J Neurosci Res 71:591-9. 2003
    ..This in vitro model may be useful in attempts to study the mechanisms of this neurodegenerative disease and to examine therapeutic potentials...
  10. ncbi request reprint Detection of N epsilon-(carboxymethyl)lysine (CML) and non-CML advanced glycation end-products in the anterior horn of amyotrophic lateral sclerosis spinal cord
    Seiji Kikuchi
    Department of Neurology, Hokkaido University School of Medicine, Sapporo, Japan
    Amyotroph Lateral Scler Other Motor Neuron Disord 3:63-8. 2002
    ..We previously reported the existence of an Amadori product, 1-hexitol-lysine (1-HL), which is formed in the early glycation reaction, in axonal spheroids of the anterior horn of the ALS spinal cord...
  11. ncbi request reprint TNF-related apoptosis inducing ligand (TRAIL) gene polymorphism in Japanese patients with multiple sclerosis
    Seiji Kikuchi
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo 060 8638, Japan
    J Neuroimmunol 167:170-4. 2005
    ..453-3.943). There were no significant associations between +1595 polymorphism and the clinical features of MS. The results indicate that the presence of the CC genotype at position 1595 in exon 5 represents a higher risk of MS...
  12. ncbi request reprint Platelet-activating factor receptor gene polymorphism in Japanese patients with multiple sclerosis
    Manabu Osoegawa
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neuroimmunol 161:195-8. 2005
    ..7%) was also significantly higher than those in healthy controls (6.9%) (p=0.019; OR, 1.78; 95% CI, 1.10-2.89). These findings suggest that the PAFR gene missense mutation has a relation to the susceptibility for MS...
  13. pmc Structural equation modeling of factors contributing to quality of life in Japanese patients with multiple sclerosis
    Hiromi Kikuchi
    College of Nursing, Sapporo City University, Sapporo, Japan
    BMC Neurol 13:10. 2013
    ..The aim of this study was to examine the causal and mutual relationships contributing to QOL in Japanese patients with MS, develop path diagrams, and explore interventions with the potential to improve patient QOL...
  14. ncbi request reprint Proteasome inhibition induces selective motor neuron death in organotypic slice cultures
    Sachiko Tsuji
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    J Neurosci Res 82:443-51. 2005
    ..01). We postulate that proteasome inhibition is an excellent model for studying the mechanisms underlying selective motor neuron death and searching for new therapeutic strategies in the treatment of ALS...
  15. ncbi request reprint Genetic polymorphisms of osteopontin in association with multiple sclerosis in Japanese patients
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo, 060 8638, Japan
    J Neuroimmunol 136:125-9. 2003
    ..Our results suggest that the 8090th polymorphism might be associated with susceptibility to MS, while the 9583rd polymorphism might be associated with age of onset of MS...
  16. doi request reprint Bone marrow stromal cells promote neurite extension in organotypic spinal cord slice: significance for cell transplantation therapy
    Hideo Shichinohe
    Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Japan
    Neurorehabil Neural Repair 22:447-57. 2008
    ..In this study, the authors aimed to clarify the underlying mechanism through which BMSCs supported CNS regeneration in the spinal cord...
  17. ncbi request reprint C-C chemokine receptor 2 gene polymorphism in Japanese patients with multiple sclerosis
    Ryuji Miyagishi
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita, Sapporo 060 8638, Hokkaido, Japan
    J Neuroimmunol 145:135-8. 2003
    ..0204). There were no significant associations between CCR2 polymorphism and the clinical features of MS. Our results indicate that the presence of CCR2-64I allele seems to provide protection against the development of MS...
  18. doi request reprint Increased prevalence, incidence, and female predominance of multiple sclerosis in northern Japan
    Hideki Houzen
    Department of Neurology, Obihiro Kosei General Hospital, Obihiro, Japan
    J Neurol Sci 323:117-22. 2012
    ....
  19. doi request reprint Decreased IL-10 production mediated by Toll-like receptor 9 in B cells in multiple sclerosis
    Makoto Hirotani
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Neuroimmunol 221:95-100. 2010
    ..Our results indicate that TLR9-mediated IL-10 production by B cells was significantly decreased in MS, and this decrease is likely due to decreased TLR9 expression in memory B cells, suggesting a role of TLR9 in immunoregulation in MS...
  20. ncbi request reprint Platelet-activating factor acetylhydrolase gene polymorphism and its activity in Japanese patients with multiple sclerosis
    Manabu Osoegawa
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neuroimmunol 150:150-6. 2004
    ....
  21. ncbi request reprint Estrogens as potential therapeutic agents in multiple sclerosis
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kitaku, Sapporo, Japan
    Cent Nerv Syst Agents Med Chem 9:87-94. 2009
    ..In this review paper, we discuss increasing evidence that points to a link between estrogen and MS. We also analyze the therapeutic potential of estrogens in MS and review current genetic studies on ER...
  22. ncbi request reprint No association of vitamin D-binding protein gene polymorphisms in Japanese patients with MS
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo 060 8638, Japan
    J Neuroimmunol 127:177-9. 2002
    ..Furthermore, no association was observed between the DBP polymorphisms and the age at disease onset. These results suggest that DBP does not contribute to the development of MS in Japanese...
  23. ncbi request reprint Role of p53 in neurotoxicity induced by the endoplasmic reticulum stress agent tunicamycin in organotypic slice cultures of rat spinal cord
    Jun Tashiro
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Hokkaido, Japan
    J Neurosci Res 85:395-401. 2007
    ..This difference might be a clue to the mechanism of the stress-response pathway and might also contribute to the potential application of p53 inhibitors for the treatment of spinal cord diseases, including amyotrophic lateral sclerosis...
  24. ncbi request reprint Brain SPECT analysis by 3D-SSP and phenotype of Parkinson's disease
    Yasunori Mito
    Department of Neurology, Asahikawa Red Cross Hospital, 1 1, Akebono, Asahikawa, Hokkaido, 070 8530, Japan
    J Neurol Sci 241:67-72. 2006
    ..We therefore investigated the association of phenotypes in untreated PD with brain perfusion on SPECT using three-dimensional stereotactic surface projection (3D-SSP) technique...
  25. doi request reprint Heterogeneity and continuum of multiple sclerosis phenotypes in Japanese according to the results of the fourth nationwide survey
    Takaaki Ishizu
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Neurol Sci 280:22-8. 2009
    ..These findings suggest that demographic features not only vary based on CMS or OSMS phenotype, but also with the presence or absence of LESCLs, and that nonetheless, these four phenotypes constitute a continuum...
  26. ncbi request reprint Comparison of the clinical courses of the opticospinal and conventional forms of multiple sclerosis in Japan
    Manabu Osoegawa
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Intern Med 44:934-8. 2005
    ..These results suggest that the irreversible disability in OS-MS is determined by relapses, rather than by chronic progression, whereas C-MS has a similar clinical course to MS in Westerners...
  27. ncbi request reprint Pure topographical disorientation following a right forceps major of the splenium lesion: a case study
    Itaru Tamura
    Department of Communication Disorders, School of Psychological Science, Health Sciences University of Hokkaido, Sapporo, Japan
    Neurocase 13:178-84. 2007
    ..These results suggested the heading disorientation was accompanied with impaired sense of quarters, although disabled sense of quarters continued beyond the recovery of heading disorientation...
  28. pmc An examination of the Apo-1/Fas promoter Mva I polymorphism in Japanese patients with multiple sclerosis
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo, 060 8638, Japan
    BMC Neurol 2:8. 2002
    ..The Apo-1/Fas gene is located in a chromosomal region that shows linkage in multiple sclerosis (MS) genome screens, and studies indicate that there is aberrant expression of the Apo-1/Fas molecule in MS...
  29. ncbi request reprint An assessment of the association between IL-2 gene polymorphisms and Japanese patients with multiple sclerosis
    Seiji Kikuchi
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, 060 8638 Sapporo, Japan
    J Neurol Sci 205:47-50. 2002
    ..Together, our findings suggest that IL-2 gene polymorphisms do not influence the susceptibility to MS or the clinical characteristics of MS in Japanese patients...
  30. doi request reprint Decreased interferon-α production in response to CpG DNA dysregulates cytokine responses in patients with multiple sclerosis
    Makoto Hirotani
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Clin Immunol 143:145-51. 2012
    ..These results suggest that CpG DNA-induced decreased IFN-α production causes pro-inflammatory cytokine secretion, and either IFN-α or IFN-β induces anti-inflammatory cytokine secretion in the adaptive immune system in MS...
  31. ncbi request reprint Susceptibility of brain microvascular endothelial cells to advanced glycation end products-induced tissue factor upregulation is associated with intracellular reactive oxygen species
    Yoshimasa Niiya
    Department of Neurosurgery, Hokkaido University Graduate School of Medicine, North 15 West 7, Kita, Sapporo 060 8638, Japan
    Brain Res 1108:179-87. 2006
    ..These results suggest that brain microvascular endothelial cells are more susceptible to AGE-induced TF upregulation than aortic endothelial cells, and that this susceptibility is associated with levels of intracellular ROS...
  32. ncbi request reprint The prevalence and clinical characteristics of MS in northern Japan
    Hideki Houzen
    Department of Neurology, Obihiro Kosei General Hospital, Obihiro, Japan
    J Neurol Sci 211:49-53. 2003
    ..In contrast to the previous reports in Japan, there was a relatively low frequency of OS-MS in Hokkaido...
  33. ncbi request reprint [Age-related working memory decline in patients with Parkinson's disease]
    Itaru Tamura
    Department of Communication Disorders, School of Psychological Science, Health Sciences University of Hokkaido, 2 5 Ainosato, Kita ku, Sapporo 002 8072, Japan
    No To Shinkei 55:335-40. 2003
    ..Such decline may be caused by peculiar processing related dysfunction of CE that assumes to be essential deficit of PD...
  34. ncbi request reprint Two-year follow-up of chronic stimulation of the posterior subthalamic white matter for tremor-dominant Parkinson's disease
    Mayumi Kitagawa
    Sapporo Azabu Neurosurgical Hospital, Hokkaido, Japan
    Neurosurgery 56:281-9; discussion 281-9. 2005
    ....
  35. doi request reprint Impact and characteristics of quality of life in Japanese patients with multiple sclerosis
    Hiromi Kikuchi
    College of Nursing, Sapporo City University, Sapporo, Japan
    Qual Life Res 20:119-31. 2011
    ..To evaluate health-related quality of life (HRQOL) in Japanese patients with multiple sclerosis (MS) and investigate associations between the results of these QOL assessments and disease severity...
  36. ncbi request reprint CTLA-4 gene polymorphism may modulate disease in Japanese multiple sclerosis patients
    T Fukazawa
    Hokuyukai Neurology Hospital, Niju Yon Ken 2 2 4 30, Nishi ku, Sapporo, Japan
    J Neurol Sci 171:49-55. 1999
    ..This CTLA-4 polymorphism may modulate the prognosis of patients with MS and may be relevant to generation of OCB in the CSF...
  37. ncbi request reprint Nationwide survey of juvenile muscular atrophy of distal upper extremity (Hirayama disease) in Japan
    Kunio Tashiro
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Amyotroph Lateral Scler 7:38-45. 2006
    ..There was a predominantly unilateral hand and forearm involvement with 'cold paresis'. The imaging findings are described...
  38. ncbi request reprint Recent advances in genetic analysis of multiple sclerosis: genetic associations and therapeutic implications
    Masaaki Niino
    Department of Neurology, Hokkaido University Hospital, Kita 14, Nishi 5, Kita ku, Sapporo 060 8648, Japan
    Expert Rev Neurother 7:1175-88. 2007
    ..Newer techniques and methods of analysis will hopefully result in better screening of individuals who are at highest risk and novel treatments...
  39. ncbi request reprint Therapeutic potential of vitamin D for multiple sclerosis
    Masaaki Niino
    Department of Neurology, Hokkaido University Hospital, Kita 14, Nishi 5, Kita ku, Sapporo 060 8648 Japan
    Curr Med Chem 15:499-505. 2008
    ..This review also discusses the therapeutic potential of vitamin D for treating MS...
  40. ncbi request reprint Brain 3D-SSP SPECT analysis in dementia with Lewy bodies, Parkinson's disease with and without dementia, and Alzheimer's disease
    Yasunori Mito
    Department of Neurology, Asahikawa Red Cross Hospital, 1 1, Akebono, Asahikawa, Hokkaido 070 8530, Japan
    Clin Neurol Neurosurg 107:396-403. 2005
    ....
  41. ncbi request reprint Both the HLA-CPB1 and -DRB1 alleles correlate with risk for multiple sclerosis in Japanese: clinical phenotypes and gender as important factors
    T Fukazawa
    Hokuyukai Neurology Hospital, Sapporo, Japan
    Tissue Antigens 55:199-205. 2000
    ..In conclusion, OS-MS is a DPB1*0501-associated distinct subtype of MS, and DPB1*0301 is the most strongly associated allele with conventional MS in Japanese. In addition, gender plays an important role in HLA association with MS...
  42. ncbi request reprint Spinocerebellar ataxia type 14 caused by a mutation in protein kinase C gamma
    Ichiro Yabe
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Arch Neurol 60:1749-51. 2003
    ..Different PRKCG mutations were found in another family with SCA and in a sporadic case from the United States. Axial myoclonus was not observed in any of these US families...
  43. ncbi request reprint The effects of neuronal induction on gene expression profile in bone marrow stromal cells (BMSC)--a preliminary study using microarray analysis
    Satoshi Yamaguchi
    Department of Neurosurgery, Hokkaido University Graduate School of Medicine, North 15 West 7, Sapporo 060 8638, Japan
    Brain Res 1087:15-27. 2006
    ....
  44. ncbi request reprint Cervical myelopathy due to a "tight dural canal in flexion" with a posterior epidural cavity
    Seiji Kikuchi
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo
    Intern Med 41:746-8. 2002
    ..When evaluating atypical cases of Hirayama's disease, the pathomechanism demonstrated in the present case should be taken into consideration...
  45. ncbi request reprint Association of vitamin D receptor gene polymorphism with multiple sclerosis in Japanese
    T Fukazawa
    Hokuyukai Neurology Hospital, Sapporo, Japan
    J Neurol Sci 166:47-52. 1999
    ....
  46. ncbi request reprint Abnormal brain MRI signals in the splenium of the corpus callosum, basal ganglia and internal capsule in a suspected case with tuberculous meningitis
    Makoto Hirotani
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo
    Intern Med 46:505-9. 2007
    ..This valuable case suggests that an immune mechanism contributed to the occurrence of central nervous system symptoms associated with tuberculous meningitis...
  47. ncbi request reprint Cystatin C in cerebrospinal fluid as a biomarker of ALS
    Sachiko Tsuji-Akimoto
    Department of Neurology, Graduate School of Medicine, Hokkaido University, Sapporo City, Hokkaido, Japan
    Neurosci Lett 452:52-5. 2009
    ..control subjects: p = 0.014 and ALS patients vs. polyneuropathy patients: p = 0.024). Cystatin C may be a useful biomarker of ALS and can be used to distinguish between ALS and polyneuropathy...
  48. ncbi request reprint Glyceraldehyde-derived advanced glycation end products in Alzheimer's disease
    Hiroshi Choei
    Department of Neuropsychiatry, Sapporo Medical University School of Medicine, Sapporo, Japan
    Acta Neuropathol 108:189-93. 2004
    ..We hypothesize that perikaryal glycer-AGE immunopositivity of neurons reflects an increase of cytoplasmic glycer-AGE along with the decline of GAPDH activity...
  49. ncbi request reprint Polymorphisms of apolipoprotein E and Japanese patients with multiple sclerosis
    M Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Mult Scler 9:382-6. 2003
    ..Although the low rate of epsilon4 allele in Japan should be taken into consideration, our results showed no relation between APOE gene polymorphisms and Japanese patients with MS...
  50. ncbi request reprint GNE mutations causing distal myopathy with rimmed vacuoles with inflammation
    I Yabe
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Neurology 61:384-6. 2003
    ..Gene analysis revealed a compound heterozygous mutation in these individuals, characterized by V572L and I472T...
  51. doi request reprint Temporal changes and geographical differences in multiple sclerosis phenotypes in Japanese: nationwide survey results over 30 years
    M Osoegawa
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mult Scler 15:159-73. 2009
    ..In Japan, four nationwide surveys of MS have been conducted. The first three were in 1972, 1982, and 1989, and we performed the fourth in 2004...
  52. ncbi request reprint Tumor necrosis factor enhancement of transient outward potassium currents in cultured rat cortical neurons
    H Houzen
    Department of Pharmacology, Hokkaido University School of Medicine, Sapporo, Japan
    J Neurosci Res 50:990-9. 1997
    ..This protective effect of TNF was cancelled by 4-aminopyridine, an A-current blocker, suggesting that the increase of A-current densities induced by TNF contributes to the neuroprotection...
  53. ncbi request reprint Heat shock protein 70 gene polymorphism in Japanese patients with multiple sclerosis
    M Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Tissue Antigens 58:93-6. 2001
    ..Our data indicate that HSP70 gene polymorphisms are not relevant in the susceptibility to or the severity of Japanese MS patients...
  54. ncbi request reprint Effect of 1,25-dihydroxyvitamin D(3) on cultured mesencephalic dopaminergic neurons to the combined toxicity caused by L-buthionine sulfoximine and 1-methyl-4-phenylpyridine
    K Shinpo
    Department of Neurology, Hokkaido University School of Medicine, Sapporo, Hokkaido, Japan
    J Neurosci Res 62:374-82. 2000
    ..These data suggest that low doses of 1,25-(OH)(2)D(3) are able to protect mesencephalic dopaminergic neurons against BSO/MPP(+)-induced toxicity that causes a depletion in glutathione content...
  55. ncbi request reprint Identification of cell types producing RANTES, MIP-1 alpha and MIP-1 beta in rat experimental autoimmune encephalomyelitis by in situ hybridization
    R Miyagishi
    Department of Neurology, Hokkaido University School of Medicine, Sapporo, Japan
    J Neuroimmunol 77:17-26. 1997
    ..Our observations support the possibility that chemokine production by T-cells, macrophages and astrocytes lead to the infiltration of inflammatory cells into the CNS parenchyma during the acute phase of EAE...
  56. ncbi request reprint Macrophage migration inhibitory factor in the cerebrospinal fluid of patients with conventional and optic-spinal forms of multiple sclerosis and neuro-Behçet's disease
    M Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, 060 8638, Sapporo, Japan
    J Neurol Sci 179:127-31. 2000
    ..910, P<0.005). These results suggest that MIF may play a pivotal role in immune-mediated diseases of the central nervous system, and that MIF may be useful in the study of differences between C-MS and OpS-MS...
  57. ncbi request reprint Estrogen receptor gene polymorphism in Japanese patients with multiple sclerosis
    M Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, 060 8638, Sapporo, Japan
    J Neurol Sci 179:70-5. 2000
    ..ERG polymorphism should be further studied in other populations to improve strategies for treatment of MS...
  58. ncbi request reprint Vitamin D receptor gene polymorphism in multiple sclerosis and the association with HLA class II alleles
    M Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, 060 8638, Sapporo, Japan
    J Neurol Sci 177:65-71. 2000
    ..0308 and P(corr)=0.0033, respectively). These results indicate that VDRG polymorphism may be associated with susceptibility to MS, and HLA alleles may correlate with risk for MS together with VDRG...
  59. ncbi request reprint An examination of the association between beta2 adrenergic receptor polymorphisms and multiple sclerosis
    M Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Mult Scler 8:475-8. 2002
    ..Together, our findings suggest that the presence of beta2AR gene polymorphisms may be inconclusive in the susceptibility to MS or in the clinical characteristics of Japanese patients with MS and, therefore, need further studies...
  60. ncbi request reprint Selective vulnerability of spinal motor neurons to reactive dicarbonyl compounds, intermediate products of glycation, in vitro: implication of inefficient glutathione system in spinal motor neurons
    K Shinpo
    Department of Neurology, Hokkaido University School of Medicine, Kita 14 Nishi 5 Kita ku, Sapporo, Japan
    Brain Res 861:151-9. 2000
    ..These data demonstrate that spinal motor neurons are more vulnerable to dicarbonyl compounds, and this selectivity might be related to the relatively inefficient GSH system in spinal motor neurons...
  61. pmc Focal (segmental) dyshidrosis in syringomyelia
    K Sudo
    Department of Neurology, Hokkaido University School of Medicine, Sapporo, Japan
    J Neurol Neurosurg Psychiatry 67:106-8. 1999
    ..Focal hyperhidrosis may be regarded as a hallmark of a relatively intact spinal cord, as well as normohidrosis...
  62. ncbi request reprint Protective effects of the TNF-ceramide pathway against glutamate neurotoxicity on cultured mesencephalic neurons
    K Shinpo
    Department of Neurology, Hokkaido University Hospital, Kita 14, Nishi 5, Kitaku, Sapporo, Japan
    Brain Res 819:170-3. 1999
    ..Since the pretreatment with sphingosine-1-phosphate (SPP) showed a neuroprotective effect, our data suggest that protective effects of TNF and C2-ceramide could be attributable to their further metabolism to SPP...
  63. ncbi request reprint The significance of oligoclonal bands in multiple sclerosis in Japan: relevance of immunogenetic backgrounds
    T Fukazawa
    Hokuyukai Neurology Hospital, Sapporo, Japan
    J Neurol Sci 158:209-14. 1998
    ..Further investigations involving more patients are warranted...
  64. ncbi request reprint Caveolin-3 gene mutation in Japanese with rippling muscle disease
    I Yabe
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, and Hokkaido Neurology Hospital, Nijyuyonken, Japan
    Acta Neurol Scand 108:47-51. 2003
    ..Recently a caveolin-3 gene (CAV3) mutation was identified in patients with autosomal dominant RMD. The objective of this study was to determine whether a similar mutation was present in two Japanese families with this condition...
  65. ncbi request reprint AMPA/kainate receptor activation inhibits neuronal delayed rectifier K+ current via Na+ entry in rat cortical neurons
    H Houzen
    Department of Pharmacology, Hokkaido University School of Medicine, Sapporo, Japan
    Biochem Biophys Res Commun 243:617-21. 1998
    ..This contributes to feed-forward excitation of neuronal cells in glutaminergic responses...
  66. ncbi request reprint Genetic polymorphisms of IL-1beta and IL-1 receptor antagonist in association with multiple sclerosis in Japanese patients
    M Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, 060 8638, Sapporo, Japan
    J Neuroimmunol 118:295-9. 2001
    ..Together, our findings suggest that IL-1beta or IL-1ra gene polymorphisms may not be relevant in the susceptibility to MS or the clinical characteristics of Japanese patients with MS...
  67. doi request reprint Genetic susceptibility to multiple sclerosis: implications of genetic research on MS therapy
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Expert Rev Neurother 2:329-8. 2002
    ..To date, these data have not been considered in the therapy of multiple sclerosis. We describe the applicability of these results toward designing specific therapies for multiple sclerosis...
  68. doi request reprint Five-year follow-up with low-dose tacrolimus in patients with myasthenia gravis
    Naoya Minami
    Department of Neurology, Hokkaido Medical Center, Sapporo, Japan
    J Neurol Sci 300:59-62. 2011
    ..Tacrolimus is an important option for treatment of MG; however, careful management is needed for long-term treatment with this drug...
  69. ncbi request reprint The writing of arabic numerals, kanji, and kana in brain-damaged patients
    Itaru Tamura
    Department of Neurology, Hokkaido University, School of Medicine, Japan
    Neuroreport 14:861-5. 2003
    ..The results suggested that Arabic numerals may be somesthetic and linked directly to the concept of number bypassing phonological analysis...
  70. ncbi request reprint Intracranial hemorrhage in neuro-Behçet's syndrome
    Seiji Kikuchi
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo
    Intern Med 41:692-5. 2002
    ..In this paper, we report three cases of neuro-Behçet's syndrome presenting with intracerebral hemorrhaging, and discuss the possible causes as they relate to cyclosporine treatment...
  71. ncbi request reprint Familial syringomyelia: the first Japanese case and review of the literature
    Ichiro Yabe
    Department of Neurology, Hokkaido University Graduate School of Medicine, N15 W7, Kita ku, Sapporo 060 8638, Japan
    Clin Neurol Neurosurg 105:69-71. 2002
    ..Twenty-one families with syringomyelia have been reported. The existence of these families indicates that genetic factors may play in role to the pathogenesis of this disorder...
  72. ncbi request reprint [IL-18 in multiple sclerosis]
    Hikoaki Fukaura
    Department of Neurology, Hokkaido University School of Medicine
    Nihon Rinsho 61:1416-21. 2003
    ..IL-18 is linked to raised IFN-gamma in MS and is induced by activated CD4(+) T cells via CD40-CD40 ligand interaction. IL-18 in MS is suppressed by treatments such as GA and IFN-beta...
  73. doi request reprint Safety and efficacy of thalidomide in patients with POEMS syndrome: a multicentre, randomised, double-blind, placebo-controlled trial
    Sonoko Misawa
    Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Lancet Neurol 15:1129-37. 2016
    ..Thalidomide suppresses VEGF and plasma cell proliferation. We aimed to assess the safety and efficacy of thalidomide for the treatment of POEMS syndrome...
  74. ncbi request reprint Primary CD30/Ki-1 positive anaplastic large cell lymphoma of the central nervous system occurring in a patient with a seventeen-year history of essential thrombocythemia
    Yasutaka Tajima
    Department of Neurology, Sapporo City General Hospital, N 11, W13, Chu o ku, Sapporo, 060 8604, Japan
    Leuk Lymphoma 44:1243-5. 2003
    ..Pathological examinations confirmed CD30/Ki-1-positive ALK negative anaplastic large cell lymphoma. The possible pathogenic mechanisms of this disease are discussed...
  75. ncbi request reprint Electrical stimulation of the posterior subthalamic area for the treatment of intractable proximal tremor
    Jun ichi Murata
    Sapporo Azabu Neurosurgical Hospital, Sapporo, Japan
    J Neurosurg 99:708-15. 2003
    ..Advances involving a less invasive method, that is, deep brain stimulation (DBS), has led to a reappraisal of this target...
  76. ncbi request reprint Deficits of working memory during mental calculation in patients with Parkinson's disease
    Itaru Tamura
    Department of Communication Disorders, School of Psychological Science, Health Sciences University of Hokkaido, 2 5 Ainosato, Kitaku, Hokkaido, 002 8072, Sapporo, Japan
    J Neurol Sci 209:19-23. 2003
    ....
  77. ncbi request reprint [Myoclonus epilepsy]
    Takuya Higashi
    Department of Neurology, Hokkaido University Graduate School of Medicine
    Nihon Rinsho 60:515-8. 2002
  78. ncbi request reprint Ibudilast, a nonselective phosphodiesterase inhibitor, regulates Th1/Th2 balance and NKT cell subset in multiple sclerosis
    Juan Feng
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryomachi, Aoba ku, Sendai 980 8574, Japan
    Mult Scler 10:494-8. 2004
    ..None of the significant immunological changes were seen in healthy subjects or untreated MS patients. Ibudilast may be a promising therapy for MS and its clinical effects warrant further study...
  79. doi request reprint Increasing prevalence and incidence of multiple sclerosis in northern Japan
    H Houzen
    Department of Neurology, Obihiro Kosei General Hospital, Obihiro, Japan
    Mult Scler 14:887-92. 2008
    ..A second epidemiologic survey was conducted to assess changes in MS prevalence and incidence over the last 30 years in Tokachi province of Hokkaido, the northernmost island of Japan...
  80. ncbi request reprint Genomic HLA profiles of MS in Hokkaido, Japan: important role of DPB1*0501 allele
    T Fukazawa
    Hokuyukai Neurology Hospital, Sapporo, Japan
    J Neurol 247:175-8. 2000
    ..58%, P = 0.0084), although the differences were not statistically significant. Our results indicate that OS-MS is a DPB 1*0501-associated subgroup of MS, and that DPB1*0501 is also correlated with risk of conventional MS in Japanese...
  81. pmc Latitude and HLA-DRB1*04:05 independently influence disease severity in Japanese multiple sclerosis: a cross-sectional study
    Yuri Nakamura
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    J Neuroinflammation 13:239. 2016
    ..We aimed to clarify the effects of latitude and the HLA-DRB1 and HLA-DPB1 genes on disease severity in Japanese patients with MS...
  82. pmc Fingolimod (FTY720) therapy in Japanese patients with relapsing multiple sclerosis over 12 months: results of a phase 2 observational extension
    Jun Ichi Kira
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    BMC Neurol 14:21. 2014
    ..Here we report a 6-month observational extension that evaluated efficacy and safety in patients who received fingolimod continuously for 12 months or who switched from placebo to fingolimod...
  83. ncbi request reprint [Treatment for patients with early Parkinson's disease]
    Seiji Kikuchi
    Department of Neurology, Hokkaido University Graduate School of Medicine
    Nihon Rinsho 62:1701-8. 2004
    ....
  84. ncbi request reprint Late onset ataxia phenotype in dentatorubro-pallidoluysian atrophy (DRPLA)
    Ichiro Yabe
    Department of Neurology, Hokkaido University School of Medicine, N 15 W 7, Kita ku, Sapporo 060 8638, Japan
    J Neurol 249:432-6. 2002
    ..Our experience implies that DRPLA must be taken into account in the differential diagnosis of late onset ataxic disorders, since it can easily be overlooked...
  85. ncbi request reprint [A guideline for the treatment of Parkinson's disease]
    Yoshikuni Miziuno
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Rinsho Shinkeigaku 42:421-94. 2002
  86. doi request reprint Expansion of CD4+CD28- T cells producing high levels of interferon-{gamma} in peripheral blood of patients with multiple sclerosis
    Y Miyazaki
    Division of Immunobiology, Research Section of Pathophysiology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Mult Scler 14:1044-55. 2008
    ..Thus, an additional treatment strategy that specifically targets this cell population may enhance the beneficial effect of IFN-beta on MS...
  87. ncbi request reprint A three-dimensional approach for understanding the spectrum of idiopathic inflammatory demyelinating disorders: importance of the 'attack-related severity' axis
    T Fukazawa
    Nishimaruyama Hospital, Maruyama Nishimachi 4 7 25, Sapporo, Japan
    Mult Scler 13:199-207. 2007
    ....
  88. ncbi request reprint Brain catecholamine alterations and pathological features with aging in Parkinson disease model rat induced by Japanese encephalitis virus
    N Hamaue
    Department of Pharmacology, Health Sciences University of Hokkaido, Ishikari Tobetsu, 061 0293, Hokkaido, Japan
    Neurochem Res 31:1451-5. 2006
    ..These results suggest that DA decrease and pathological changes in JEV-infected model rats persist for a long time, at least up to 180 days, and this model will be useful for the evaluation of new anti-parkinsonian agents...
  89. ncbi request reprint Amelioration of experimental autoimmune encephalomyelitis in C57BL/6 mice by an agonist of peroxisome proliferator-activated receptor-gamma
    M Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita-15 Nishi-7, Kita-ku, 060-8638, Sapporo, Japan
    J Neuroimmunol 116:40-8. 2001
    ..We found that troglitazone attenuated the inflammation and decreased the clinical symptoms. It was suggested that the amelioration was attributed to the attenuation of pro-inflammatory cytokine gene expressions...
  90. ncbi request reprint Phrenic nerve conduction in infancy and early childhood
    T Imai
    Department of Neurology, School of Medicine, Sapporo Medical University, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
    Muscle Nerve 23:915-8. 2000
    ..The results are valuable not only as a reference for the diagnosis of patients with phrenic nerve palsy, but also as an indicator of the normal development of the phrenic nerve...
  91. ncbi request reprint [Susceptibility genes for multiple sclerosis]
    Toshiyuki Fukazawa
    Hokuyukai Neurology Hospital
    Nihon Rinsho 61:1311-6. 2003
    ..Appropriate case ascertainment and collection as well as proper statistical method are needed to isolate the susceptibility genes for MS...
  92. pmc Palmitate-induced apoptosis of microvascular endothelial cells and pericytes
    Sho ichi Yamagishi
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Mol Med 8:179-84. 2002
    ..In this study, we investigated the influence of palmitate, a major saturated free fatty acid in plasma, on the apoptotic cell death of cultured microvascular endothelial cells (EC) and retinal pericytes...
  93. doi request reprint Baló's concentric sclerosislike lesion in the brainstem of a multiple sclerosis patient
    Richiro Kishimoto
    J Neurol 255:760-1. 2008
  94. ncbi request reprint Attack-related severity: a key factor in understanding the spectrum of idiopathic inflammatory demyelinating disorders
    Toshiyuki Fukazawa
    Hokuyukai Neurology Hospital, Niju Yon Ken 2 2 4 30, Nishi ku, Sapporo 063 0802, Japan
    J Neurol Sci 225:71-8. 2004
    ..Attack-related severity may be an important factor if validated by prospective studies defining criteria and establishing relationships to disease course and treatment regimens...
  95. ncbi request reprint T cell gene expression profiling identifies distinct subgroups of Japanese multiple sclerosis patients
    Jun ichi Satoh
    Department of Immunology, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Neuroimmunol 174:108-18. 2006
    ..These results suggest that T-cell gene expression profiling is valuable to identify distinct subgroups of MS associated with differential disease activity and therapeutic response to IFNbeta...
  96. ncbi request reprint CTLA-4 gene polymorphism is not associated with conventional multiple sclerosis in Japanese
    Toshiyuki Fukazawa
    Hokuyukai Neurology Hospital, Niju Yon Ken 2 2 4 30, Nishi ku, Sapporo 063 0802, Japan
    J Neuroimmunol 159:225-9. 2005
    ....
  97. ncbi request reprint Diagnostic utility of serum or cerebrospinal fluid levels of toxic advanced glycation end-products (TAGE) in early detection of Alzheimer's disease
    Masayoshi Takeuchi
    Department of Pathophysiological Science, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho 3 Kanagawa machi, Kanazawa 920 1181, Japan
    Med Hypotheses 69:1358-66. 2007
    ..In this paper, we discuss the pathophysiological role for toxic AGEs (TAGE) in AD. We further review here the possibility that serum or cerebrospinal fluid levels of TAGE could become a promising biomarker for early detection of AD...
  98. ncbi request reprint Neurotoxicity of acetaldehyde-derived advanced glycation end products for cultured cortical neurons
    Masayoshi Takeuchi
    Department of Biochemistry, Faculty of Pharmaceutical Science, Hokuriku University, Kanazawa, Japan
    J Neuropathol Exp Neurol 62:486-96. 2003
    ..The AA-AGE epitope was detected in human brain of alcoholism. We propose that the structural epitope AA-AGE is an important toxic moiety for neuronal cells in alcoholism...
  99. ncbi request reprint Subacute syphilitic meningomyelitis with characteristic spinal MRI findings
    Seiji Kikuchi
    J Neurol 250:106-7. 2003
  100. ncbi request reprint Incadronate disodium inhibits advanced glycation end products-induced angiogenesis in vitro
    Tamami Okamoto
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Japan
    Biochem Biophys Res Commun 297:419-24. 2002
    ..Incadronate disodium may be a promising remedy for treatment of patients with proliferative diabetic retinopathy...
  101. ncbi request reprint Pigment epithelium-derived factor (PEDF) blocks angiotensin II-induced T cell proliferation by suppressing autocrine production of interleukin-2
    Sho ichi Yamagishi
    Department of Internal Medicine III, Kurume University School of Medicine, Japan
    Med Chem 2:265-9. 2006
    ..Blockade by PEDF of T cell activation may become a novel therapeutic target for atherosclerosis...