H Kida

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. ncbi request reprint Library of influenza virus strains for vaccine and diagnostic use against highly pathogenic avian influenza and human pandemics
    H Kida
    Department of Disease Control, Hokkaido University Graduate School of Veterinary Medicine, Sapporo, Japan
    Dev Biol (Basel) 124:69-72. 2006
  2. ncbi request reprint [Looking back upon the confusion of avian, swine, and pandemic influenza]
    Hiroshi Kida
    The Graduate School of Veterinary Medicine, The Research Center for Zoonosis Control, Hokkaido University
    Uirusu 60:17-9. 2010
  3. pmc Characterization of a non-pathogenic H5N1 influenza virus isolated from a migratory duck flying from Siberia in Hokkaido, Japan, in October 2009
    Naoki Yamamoto
    Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita ku, Sapporo, Hokkaido 060 0818, Japan
    Virol J 8:65. 2011
  4. ncbi request reprint [For the prevention and control of pandemic influenza]
    Hiroshi Kida
    Department of Disease Control, Hokkaido University Graduate School of Veterinary Medicine, North 18, West 9, Kita ku, Sapporo 060 0818, Hokkaido, Japan
    Uirusu 53:71-4. 2003
  5. pmc Genetic analysis of an H5N2 highly pathogenic avian influenza virus isolated from a chicken in a live bird market in Northern Vietnam in 2012
    Tatsuya Nishi
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Vet Med Sci 76:85-7. 2014
  6. pmc Excessive cytokine response to rapid proliferation of highly pathogenic avian influenza viruses leads to fatal systemic capillary leakage in chickens
    Saya Kuribayashi
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    PLoS ONE 8:e68375. 2013
  7. pmc Antiviral activity of stachyflin on influenza A viruses of different hemagglutinin subtypes
    Yurie Motohashi
    Department of Disease Control, Hokkaido University, Sapporo, Japan
    Virol J 10:118. 2013
  8. pmc Potency of a vaccine prepared from A/swine/Hokkaido/2/1981 (H1N1) against A/Narita/1/2009 (H1N1) pandemic influenza virus strain
    Masatoshi Okamatsu
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita ku, Sapporo 060 0818, Japan
    Virol J 10:47. 2013
  9. pmc The PB2, PA, HA, NP, and NS genes of a highly pathogenic avian influenza virus A/whooper swan/Mongolia/3/2005 (H5N1) are responsible for pathogenicity in ducks
    Masahiro Kajihara
    Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan
    Virol J 10:45. 2013
  10. pmc H9N2 influenza virus acquires intravenous pathogenicity on the introduction of a pair of di-basic amino acid residues at the cleavage site of the hemagglutinin and consecutive passages in chickens
    Kosuke Soda
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060 0818, Japan
    Virol J 8:64. 2011

Collaborators

Detail Information

Publications109 found, 100 shown here

  1. ncbi request reprint Library of influenza virus strains for vaccine and diagnostic use against highly pathogenic avian influenza and human pandemics
    H Kida
    Department of Disease Control, Hokkaido University Graduate School of Veterinary Medicine, Sapporo, Japan
    Dev Biol (Basel) 124:69-72. 2006
    ..Their pathogenicity, antigenicity, genetic information, and yield in chicken embryo have been analysed and registered in the database...
  2. ncbi request reprint [Looking back upon the confusion of avian, swine, and pandemic influenza]
    Hiroshi Kida
    The Graduate School of Veterinary Medicine, The Research Center for Zoonosis Control, Hokkaido University
    Uirusu 60:17-9. 2010
    ..The preparedness for pandemic influenza should be based on the measures how to control the seasonal influenza that causes thousands of deaths and hundreds of encephalopathy every year in Japan...
  3. pmc Characterization of a non-pathogenic H5N1 influenza virus isolated from a migratory duck flying from Siberia in Hokkaido, Japan, in October 2009
    Naoki Yamamoto
    Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita ku, Sapporo, Hokkaido 060 0818, Japan
    Virol J 8:65. 2011
    ..The isolate was assessed for pathogenicity in chickens, domestic ducks, and quails and analyzed antigenically and phylogenetically...
  4. ncbi request reprint [For the prevention and control of pandemic influenza]
    Hiroshi Kida
    Department of Disease Control, Hokkaido University Graduate School of Veterinary Medicine, North 18, West 9, Kita ku, Sapporo 060 0818, Hokkaido, Japan
    Uirusu 53:71-4. 2003
  5. pmc Genetic analysis of an H5N2 highly pathogenic avian influenza virus isolated from a chicken in a live bird market in Northern Vietnam in 2012
    Tatsuya Nishi
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Vet Med Sci 76:85-7. 2014
    ....
  6. pmc Excessive cytokine response to rapid proliferation of highly pathogenic avian influenza viruses leads to fatal systemic capillary leakage in chickens
    Saya Kuribayashi
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    PLoS ONE 8:e68375. 2013
    ..The present results indicate that an excessive cytokine response is induced by rapid and extensive proliferation of HPAIV and causes fatal multiple organ failure in chickens. ..
  7. pmc Antiviral activity of stachyflin on influenza A viruses of different hemagglutinin subtypes
    Yurie Motohashi
    Department of Disease Control, Hokkaido University, Sapporo, Japan
    Virol J 10:118. 2013
    ....
  8. pmc Potency of a vaccine prepared from A/swine/Hokkaido/2/1981 (H1N1) against A/Narita/1/2009 (H1N1) pandemic influenza virus strain
    Masatoshi Okamatsu
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita ku, Sapporo 060 0818, Japan
    Virol J 10:47. 2013
    ..To prepare for the emergence of pandemic influenza, we have established a library of virus strains isolated from birds, pigs, and humans in global surveillance studies...
  9. pmc The PB2, PA, HA, NP, and NS genes of a highly pathogenic avian influenza virus A/whooper swan/Mongolia/3/2005 (H5N1) are responsible for pathogenicity in ducks
    Masahiro Kajihara
    Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan
    Virol J 10:45. 2013
    ..Another HPAIV strain, A/whooper swan/Mongolia/3/2005 (H5N1) (MON3) isolated from a dead swan, however, caused neurological dysfunction and death in ducks...
  10. pmc H9N2 influenza virus acquires intravenous pathogenicity on the introduction of a pair of di-basic amino acid residues at the cleavage site of the hemagglutinin and consecutive passages in chickens
    Kosuke Soda
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060 0818, Japan
    Virol J 8:64. 2011
    ....
  11. ncbi request reprint [Avian influenza virus]
    Hiroshi Kida
    Department of Disease Control Hokkaido University Graduate School of Veterinary Medicine, Kita18, Nishi 9, Kita ku, Sapporo 060 0818
    Uirusu 54:93-6. 2004
    ..The outbreaks also emphasized the need to continue active surveillance on avian influenza throughout the year to undertake aggressive emergency control measures as soon as an infection is detected...
  12. ncbi request reprint [Report of the 50th annual meeting of the Japanese Society for Virology]
    Hiroshi Kida
    Department of Disease Control, Hokkaido University Graduate School of Veterinary Medicine, North 18, West 9, Kita ku, Sapporo 060 0818, Hokkaido, Japan
    Uirusu 53:93-4. 2003
  13. ncbi request reprint Suppression of pseudorabies virus replication by a mutant form of immediate-early protein IE180 repressing the viral gene transcription
    E Ono
    Institute of Immunological Science, Hokkaido University, Sapporo, Japan
    Vet Microbiol 60:107-17. 1998
    ..The present results indicate that the resistance of the cells to PRV infection was due to repression of the IE gene transcription by the IE 180 mutant...
  14. ncbi request reprint Pathogenicity of a highly pathogenic avian influenza virus, A/chicken/Yamaguchi/7/04 (H5N1) in different species of birds and mammals
    N Isoda
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Arch Virol 151:1267-79. 2006
    ..The virus was highly pathogenic to all the birds tested. Mice were susceptible to infection with a low mortality rate and miniature pigs were resistant to infection with the virus...
  15. ncbi request reprint Structure of the immediate early gene of canine herpesvirus
    M Miyoshi
    Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Arch Virol 144:407-20. 1999
    ..DNA binding and transcriptional activation domains were found in the IE protein. A spliced region of the IE gene transcript was determined in its 5' non-coding region...
  16. ncbi request reprint Persistence of viral RNA segments in the central nervous system of mice after recovery from acute influenza A virus infection
    C H Park
    Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Vet Microbiol 97:259-68. 2003
    ..These findings suggest that viral genomes of neurovirulent influenza virus persist with restricted transcriptive activity in the CNS of the mice even after clinical recovery from the infection...
  17. ncbi request reprint Detection of canine herpesvirus DNA in the ganglionic neurons and the lymph node lymphocytes of latently infected dogs
    M Miyoshi
    Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    J Vet Med Sci 61:375-9. 1999
    ..CHV DNA was detected in the trigeminal ganglia and the retropharyngeal lymph nodes. In situ hybridization study of the tissues revealed that CHV genome persisted in the nuclei of ganglionic neurons and lymphocytes...
  18. ncbi request reprint The vagus nerve is one route of transneural invasion for intranasally inoculated influenza a virus in mice
    K Matsuda
    Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Vet Pathol 41:101-7. 2004
    ..The results of this study, thus, demonstrate that neurotropic influenza virus travels to the CNS mainly via the vagus nerve...
  19. ncbi request reprint A rapid and highly sensitive method for diagnosis of equine influenza by antigen detection using immuno-PCR
    H Ozaki
    Department of Disease Control, Hokkaido University Graduate School of Veterinary Medicine, Sapporo 060-0818, Japan
    Jpn J Vet Res 48:187-95. 2001
    ..For the detection of the hemagglutinin (HA) subtype-specific antigen, this assay using anti-HA monoclonal antibodies attained a sensitivity of up to 10(7.0-8.0) times higher than those by virus isolation or by RT-PCR...
  20. ncbi request reprint Antigenic variation among equine H 3 N 8 influenza virus hemagglutinins
    H Ozaki
    Department of Disease Control, Hokkaido University Graduate School of Veterinary Medicine, Sapporo 060-0818, Japan
    Jpn J Vet Res 48:177-86. 2001
    ..It is also therefore recommended that a representative Eurasian strain should be included as a replacement of A/equine/Kentucky/1/81...
  21. ncbi request reprint Mucosal vaccination against influenza: protection of pigs immunized with inactivated virus and ether-split vaccine
    Y K Lim
    Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan
    Jpn J Vet Res 48:197-203. 2001
    ....
  22. pmc Infectivity-enhancing antibodies to Ebola virus glycoprotein
    A Takada
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan
    J Virol 75:2324-30. 2001
    ..They also raise issues about the development of Ebola virus vaccines and the use of passive prophylaxis or therapy with Ebola virus GP antibodies...
  23. ncbi request reprint Detection of antibodies to the nonstructural protein (NS1) of influenza A virus allows distinction between vaccinated and infected horses
    H Ozaki
    Department of Disease Control, Hokkaido University Graduate School of Veterinary Medicine, Sapporo 060-0818, Japan
    Vet Microbiol 82:111-9. 2001
    ..The results indicate that the present method is useful for serological diagnosis to distinguish horses infected with equine H3 influenza viruses from those immunized with the inactivated vaccine...
  24. ncbi request reprint Receptor specificity of influenza A viruses correlates with the agglutination of erythrocytes from different animal species
    T Ito
    Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Virology 227:493-9. 1997
    ..avian and equine viruses) recognize NeuGc alpha2,3Gal. These findings also show that agglutinating assays with erythrocytes from different animal species would be useful in characterizing the receptor specificity of influenza A viruses...
  25. ncbi request reprint Pathogenicity of H5 influenza viruses for ducks
    N Kishida
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Arch Virol 150:1383-92. 2005
    ..The present results demonstrate that the pathogenicity of influenza viruses for ducks does not correlate with that for chickens and that replication of the virus in the brain is critical for ducks to show neurological signs...
  26. ncbi request reprint Development of an immunochromatographic test kit for rapid detection of bovine viral diarrhea virus antigen
    K Kameyama
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Sapporo 060 0818, Japan
    J Virol Methods 138:140-6. 2006
    ..The BVDV antigen was detected in 1 ml of blood using a relatively simple procedure. This test kit should be useful for rapid diagnosis of BVD...
  27. ncbi request reprint Pseudorabies virus (PRV) early protein 0 activates PRV gene transcription in combination with the immediate-early protein IE180 and enhances the infectivity of PRV genomic DNA
    E Ono
    Laboratory of Animal Experiments, Hokkaido University, Sapporo, Japan
    Vet Microbiol 63:99-107. 1998
    ....
  28. ncbi request reprint Co-infection of Staphylococcus aureus or Haemophilus paragallinarum exacerbates H9N2 influenza A virus infection in chickens
    N Kishida
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Arch Virol 149:2095-104. 2004
    ..The present results indicate that co-infection of H9N2 influenza virus with S. aureus or H. paragallinarum enhances the replication of the virus in chickens, resulting in exacerbation of the H9N2 virus infection...
  29. ncbi request reprint A serological survey of minute virus of canines (MVC; canine parvovirus type-1) in dogs in the Tokai area of Japan
    A Hashimoto
    Laboratory of Pathobiology, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Jpn J Vet Res 49:249-53. 2001
    ..From this serosurvey, MVC appears to be established in the dog population in Japan. MVC may have a role as a newly recognized viral pathogen of dogs in Japan...
  30. ncbi request reprint Structure of the infected cell protein 0 gene of canine herpesvirus
    M Miyoshi
    Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Arch Virol 145:1715-23. 2000
    ....
  31. ncbi request reprint Carboxyl terminus of the 34 kDa protein of Mycobacterium paratuberculosis shares homologous B-cell epitopes with Mycobacterium avium and Mycobacterium intracellulare
    M Malamo
    Department of Disease Control, Graduate School of Veterinary Medicine, Hakkaido University, Sapporo, 060 0818, Japan
    Vet Rec 161:853-7. 2007
    ..These epitopes reduce the diagnostic specificity of the carboxyl terminus of the 34 kDa protein, which was originally thought to contain only M paratuberculosis-specific epitopes...
  32. ncbi request reprint Resistance to pseudorabies virus infection in transgenic mice expressing the chimeric transgene that represses the immediate-early gene transcription
    E Ono
    Institute of Immunological Science, Hokkaido University, Sapporo, 060 0815, Japan
    Virology 262:72-8. 1999
    ..In the cells infected with PRV, transcription of the PRV IE gene was repressed. The present results indicate that the chimeric gene is able to exert a significant antiviral effect against PRV infection in vivo...
  33. ncbi request reprint Extensive accumulation of influenza virus NS1 protein in the nuclei causes effective viral growth in vero cells
    Hiroichi Ozaki
    Creative Research Initiative Sousei, Hokkaido University, Sapporo, Hokkaido 001 0021, Japan
    Microbiol Immunol 51:577-80. 2007
    ..This accumulation was caused by 7 amino acid differences in C-terminal region of NS1 protein. These results suggest that specific accumulation of NS1 protein may contribute to efficient viral replication in Vero cells...
  34. ncbi request reprint Application of carbon nanotubes for detecting anti-hemagglutinins based on antigen-antibody interaction
    Seiji Takeda
    Graduate School of Engineering, Hokkaido University, Kita 13 Nishi 8 Kita ku, Sapporo 060 8628, Japan
    Biosens Bioelectron 21:201-5. 2005
    ..The sensitivity of the CNT sensor was higher than that of an ELISA system. This method constitutes a new tool to analyze interaction among biomolecules on a substrate...
  35. ncbi request reprint A synthetic peptide from a heptad repeat region of herpesvirus glycoprotein B inhibits virus replication
    Katsunori Okazaki
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Gen Virol 85:2131-7. 2004
    ..Possible mechanisms of membrane fusion inhibition by the peptide are discussed...
  36. ncbi request reprint Serological evidence of influenza A virus infection in Kuril harbor seals (Phoca vitulina stejnegeri) of Hokkaido, Japan
    Kei Fujii
    Laboratory of Wildlife Biology, Graduate School of Veterinary Medicine, Hokkaido University, Japan
    J Vet Med Sci 69:259-63. 2007
    ..For definitive diagnosis, detection of the virus from the tissue or mucus of seals is required...
  37. ncbi request reprint Genetic recombination at different points in the Npro-coding region of bovine viral diarrhea viruses and the potentials to change their antigenicities and pathogenicities
    K Kameyama
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Sapporo 060 0818, Japan
    Virus Res 116:78-84. 2006
    ....
  38. ncbi request reprint Serological prevalence of Leptospira interrogans serovar Bratislava in horses in Mongolia
    N Odontsetseg
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Vet Rec 157:518-9. 2005
  39. ncbi request reprint The amino-terminal residue of glycoprotein B is critical for neutralization of bovine herpesvirus 1
    Katsunori Okazaki
    Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Virus Res 115:105-11. 2006
    ..These findings indicate that the amino-terminal residue of gB is critical for neutralization of BHV1...
  40. pmc PB2 protein of a highly pathogenic avian influenza virus strain A/chicken/Yamaguchi/7/2004 (H5N1) determines its replication potential in pigs
    Rashid Manzoor
    Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    J Virol 83:1572-8. 2009
    ..The D256G and E627K mutations enhanced viral polymerase activity in the mammalian cells, correlating with replication of virus in pigs. These results indicate that the PB2 protein restricts the growth of Ck/Yamaguchi/04 (H5N1) in pigs...
  41. ncbi request reprint Detection of influenza virus hemagglutinin with randomly immobilized anti-hemagglutinin antibody on a carbon nanotube sensor
    Seiji Takeda
    Creative Research Initiative Sousei, Hokkaido University, Kita 21, Nishi 10 Kita ku, Sapporo 001 0021, Japan
    J Nanosci Nanotechnol 7:752-6. 2007
    ..This method constitutes a new tool to analyze interactions among biomolecules on a substrate...
  42. ncbi request reprint Seroepidemiological evidence of avian H4, H5, and H9 influenza A virus transmission to pigs in southeastern China
    Ai Ninomiya
    Department of Disease Control, Hokkaido University Graduate School of Veterinary Medicine, 060 0818, Sapporo, Japan
    Vet Microbiol 88:107-14. 2002
    ..The present results indicate that avian influenza viruses have been transmitted to pig populations in southeastern China...
  43. pmc Cross-protective potential of a novel monoclonal antibody directed against antigenic site B of the hemagglutinin of influenza A viruses
    Reiko Yoshida
    Department of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Sapporo, Hokkaido, Japan
    PLoS Pathog 5:e1000350. 2009
    ....
  44. ncbi request reprint Induction of interferon-inducible protein-10 and monokine induced by interferon-gamma from human endothelial cells infected with Influenza A virus
    N Ishiguro
    Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan
    Arch Virol 149:17-34. 2004
    ..The elevation of IP-10 and Mig gene expression in infected HUVECs was not accompanied by the elevation of IFN-gamma gene expression, indicating that the elevation of IP-10 and Mig gene expression was independent of the IFN-gamma pathway...
  45. ncbi request reprint Phylogenic analysis of the M genes of influenza viruses isolated from free-flying water birds from their Northern Territory to Hokkaido, Japan
    Rashid Manzoor
    Department of Disease Control, Laboratory of Microbiology, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9 Kita Ku, Sapporo, Hokkaido, 060 0818, Japan
    Virus Genes 37:144-52. 2008
    ..The M genes of 65 strains were grouped into three different sublineages, indicating that influenza viruses circulating in different populations of free-flying water birds have evolved independently in nature...
  46. pmc Assembly and budding of Ebolavirus
    Takeshi Noda
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    PLoS Pathog 2:e99. 2006
    ..These data form a foundation for the identification and development of potential antiviral agents to combat the devastating disease caused by this virus...
  47. ncbi request reprint Serological evidence of leptospiral infection in pig populations in different districts in Japan
    Michiko Naito
    Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Japan
    Microbiol Immunol 51:593-9. 2007
    ..In addition, it is the first detection of antibodies to leptospires belonging to serovars Javanica and Tarassovi in pigs in Japan...
  48. ncbi request reprint Potency of an inactivated avian influenza vaccine prepared from a non-pathogenic H5N1 reassortant virus generated between isolates from migratory ducks in Asia
    Norikazu Isoda
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18 jyo Nishi 9, Kita ku, Sapporo, Hokkaido 060 0818, Japan
    Arch Virol 153:1685-92. 2008
    ..survived. These results indicate that the present vaccine confers clinical protection and reduction of virus shedding against highly pathogenic avian influenza virus challenge and should be useful as an optional tool in emergency cases...
  49. ncbi request reprint [Distribution and circulation of influenza viruses in nature]
    Hiroshi Kida
    Department of Disease Control, Hokkaido University, Graduate School of Veterinary Medicine
    Nihon Rinsho 61:1865-71. 2003
    ....
  50. pmc Influenza A virus polymerase inhibits type I interferon induction by binding to interferon beta promoter stimulator 1
    Atsushi Iwai
    Department of Bioresources, hHokkaido University Research Center for Zoonosis Control, North 20, West 10 Kita ku, Sapporo, Hokkaido 001 0020, Japan
    J Biol Chem 285:32064-74. 2010
    ..These findings demonstrate that the viral polymerase plays an important role for regulating host anti-viral response through the binding to IPS-1 and inhibition of IFN╬▓ production...
  51. ncbi request reprint Development of ELISA to detect antibodies specific to Mycobacterium avium subsp. paratuberculosis with truncated 34 kDa proteins
    Mumeka Malamo
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Jpn J Vet Res 54:99-107. 2006
    ..These results indicate that the established ELISA detects antibodies specific to M. paratuberculosis with high specificity and sensitivity and is an useful tool for the screening of Johne's disease...
  52. ncbi request reprint Intranasal administration of a synthetic peptide vaccine encapsulated in liposome together with an anti-CD40 antibody induces protective immunity against influenza A virus in mice
    Ai Ninomiya
    Department of Disease Control, Hokkaido University Graduate School of Veterinary Medicine, Sapporo 060 0818, Japan
    Vaccine 20:3123-9. 2002
    ..This approach may prove promising for developing vaccines to induce mucosal CTL responses, and seems to highlight differences between mucosal and non-mucosal immunity...
  53. ncbi request reprint Factors responsible for plaque formation of A/duck/Siberia/272/1998 (H13N6) influenza virus on MDCK cells
    Yoshimi Tsuda
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Nishi 9, Kita 18, Kita ku, Sapporo 060 0818, Japan
    Virus Res 140:194-8. 2009
    ....
  54. ncbi request reprint Serological surveillance of canine leptospirosis in Mongolia
    N Odontsetseg
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Sapporo 060 0818, Japan
    Vet Rec 157:120-1. 2005
  55. ncbi request reprint The invasion routes of neurovirulent A/Hong Kong/483/97 (H5N1) influenza virus into the central nervous system after respiratory infection in mice
    C H Park
    Laboratory of Comparative Pathology, Hokkaido University, Sapporo, Japan
    Arch Virol 147:1425-36. 2002
    ..These findings indicate that the virus reached the CNS through afferent fibers of the olfactory, vagal, trigeminal, and sympathetic nerves following replication in the respiratory mucosa...
  56. ncbi request reprint Downregulation of beta1 integrins by Ebola virus glycoprotein: implication for virus entry
    A Takada
    Laboratory of Microbiology, Graduate School of Veterinary Medicine, Sapporo, 060 0818, Japan
    Virology 278:20-6. 2000
    ..We suggest that integrins, especially the beta1 group, might interact with the GP and perhaps be involved in Ebola virus entry into cells...
  57. ncbi request reprint Cleavage of the NS2-3 protein in the cells of cattle persistently infected with non-cytopathogenic bovine viral diarrhea virus
    Ken Ichiro Kameyama
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Microbiol Immunol 52:277-82. 2008
    ..Furthermore, NS3 proteins were detected in many tissues of PI cattle, such as lymphoid tissue, brain, thyroid, lung, and kidney. These results suggest that the NS2-3 protein of ncp BVDV cleaves in vivo...
  58. ncbi request reprint H2N5 influenza virus isolates from terns in Australia: genetic reassortants between those of the Eurasian and American lineages
    Noriko Kishida
    Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita ku, Sapporo 060 0818, Japan
    Virus Genes 37:16-21. 2008
    ....
  59. doi request reprint Antigenic structure of the hemagglutinin of H9N2 influenza viruses
    Masatoshi Okamatsu
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, North 18, West 9, Kita ku, Sapporo, Hokkaido, 060 0818, Japan
    Arch Virol 153:2189-95. 2008
    ..The panel of MAbs in the present study, thus, should be useful for detailed antigenic analysis of the H9 HAs for epidemiological studies, the selection of vaccine strains, and diagnosis...
  60. doi request reprint A vaccine prepared from a non-pathogenic H7N7 virus isolated from natural reservoir conferred protective immunity against the challenge with lethal dose of highly pathogenic avian influenza virus in chickens
    Saori Sakabe
    Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060 0818, Japan
    Vaccine 26:2127-34. 2008
    ..These results indicate that influenza viruses isolated from natural reservoirs are useful for vaccine strains...
  61. ncbi request reprint Seroepidemiological survey of morbillivirus infection in Kuril harbor seals (Phoca vitulina stejnegeri) of Hokkaido, Japan
    Kei Fujii
    Laboratory of Wildlife Biology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Jpn J Vet Res 54:109-17. 2006
    ..There were no difference in incidence of seals with antibodies to the viruses between males and females and between juveniles and adults...
  62. ncbi request reprint Development of vaccine strains of H5 and H7 influenza viruses
    Kosuke Soda
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, 060 0818, Japan
    Jpn J Vet Res 55:93-8. 2008
    ..These viruses should be useful to develop vaccines against H5 and H7 highly pathogenic avian influenza viruses...
  63. ncbi request reprint Genetic and pathobiological characterization of bovine viral diarrhea viruses recently isolated from cattle in Japan
    Keita Matsuno
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    J Vet Med Sci 69:515-20. 2007
    ..The present results indicate that the prevention of the infection with an appropriate vaccine and active surveillance covering healthy cattle are required for the control of BVD...
  64. ncbi request reprint Neurotropism of the 1997 Hong Kong H5N1 influenza virus in mice
    Hiroko Tanaka
    Laboratory of Microbiology, Department of Disease Control, Hokkaido University Graduate School of Veterinary Medicine, Sapporo 060 0818, Japan
    Vet Microbiol 95:1-13. 2003
    ..The results imply that neurotropism of the H5N1 virus in mice is a novel characteristic in the pathogenesis of infection by human influenza virus isolates...
  65. doi request reprint Characterization of H5N1 highly pathogenic avian influenza virus strains isolated from migratory waterfowl in Mongolia on the way back from the southern Asia to their northern territory
    Yoshihiro Sakoda
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Virology 406:88-94. 2010
    ..The present results demonstrate that wild waterfowl were sporadically infected with H5N1 HPAI viruses prevailing in domestic poultry in the southern Asia and died in Mongolia on the way back to their northern territory in spring...
  66. ncbi request reprint Improvement of a rapid diagnosis kit to detect either influenza A or B virus infections
    Gui Rong Bai
    Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Vet Med Sci 68:35-40. 2006
    ..The kit also detected all of the 15 representative influenza B virus strains tested. The ESPLINE INFLUENZA A&B-N is thus a rapid and highly sensitive and specific kit for the diagnosis of either influenza A or B virus infections...
  67. doi request reprint Antigenic and genetic analysis of H5 influenza viruses isolated from water birds for the purpose of vaccine use
    Kosuke Soda
    Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita ku, Sapporo, Hokkaido, 060 0818, Japan
    Arch Virol 153:2041-8. 2008
    ..The present results support the notion that the H5 isolates and the reassortant H5N1 strain should be useful for vaccine preparation...
  68. ncbi request reprint Serological evidence of the persistence of infection with Leptospira interrogans serovar Hardjo in cattle in Mongolia
    Namsraijav Odontsetseg
    Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Sapporo, Hokkaido 060 0818, Japan
    Microbiol Immunol 49:865-9. 2005
    ....
  69. ncbi request reprint Evaluation of the ESPLINE INFLUENZA A&B-N Kit for the diagnosis of avian and swine influenza
    Gui Rong Bai
    Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060 0818, Japan
    Microbiol Immunol 49:1063-7. 2005
    ..The kit was found to be sensitive and specific enough for the rapid diagnosis of infections of influenza A virus in chickens and pigs...
  70. doi request reprint Characterization of H3N6 avian influenza virus isolated from a wild white pelican in Zambia
    Edgar Simulundu
    Department of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Kita 20, Nishi 10, Kita ku, Sapporo, 001 0020, Japan
    Arch Virol 154:1517-22. 2009
    ..The present study underscores the need for continued monitoring of avian influenza viruses in Eurasia and Africa...
  71. doi request reprint Lipopolysaccharide treatment and inoculation of influenza A virus results in influenza virus-associated encephalopathy-like changes in neonatal mice
    Tomohisa Tanaka
    Laboratorie of Comparative Pathology, Hokkaido University, Sapporo, Japan
    J Neurovirol 16:125-32. 2010
    ..These results suggested that the mice treated with IAV+LPS are possible animal models of IAE, and that hypercytokinemia and/or the involvement of endotoxemia in IAV infection are possible causes of IAE...
  72. ncbi request reprint The effects of antipyretics on influenza virus encephalitis in mice and chicks
    Yuji Sunden
    Laboratory of Comparative Pathology, School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    J Vet Med Sci 65:1185-8. 2003
    ..We here demonstrate that antipyretic treatment aggravated the hematogenous spread of the influenza virus to the CNS in chicks, but did not affect the transneural infection in mice...
  73. ncbi request reprint In vitro demonstration of neural transmission of avian influenza A virus
    Kazuya Matsuda
    Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Gen Virol 86:1131-9. 2005
    ....
  74. pmc Polymorphisms and the differential antiviral activity of the chicken Mx gene
    Jae Hong Ko
    Laboratory of Experimental Animal Science, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Genome Res 12:595-601. 2002
    ..Thus, a single amino acid substitution influences the antiviral activity of Mx in domesticated chickens...
  75. pmc Ebola virus VP40 drives the formation of virus-like filamentous particles along with GP
    Takeshi Noda
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Virol 76:4855-65. 2002
    ..These results demonstrated the central role of VP40 in formation of the filamentous structure of Ebola virions and may suggest an interaction between VP40 and GP in morphogenesis...
  76. ncbi request reprint Nucleocapsid-like structures of Ebola virus reconstructed using electron tomography
    Takeshi Noda
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Vet Med Sci 67:325-8. 2005
    ..Reconstruction of these tubular NC-like structures of Ebola virus showed them to be composed of left-handed helices spaced at short intervals, which is structurally consistent with other non-segmented negative-strand RNA viruses...
  77. ncbi request reprint Viral and bacterial diseases in livestock in Mongolia
    Namsraijav Odontsetseg
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Jpn J Vet Res 52:151-62. 2005
    ..A large-scale surveillance of infectious diseases in animals and management of appropriate preventive measures are urgently required in Mongolia...
  78. ncbi request reprint Novel trivalent anti-influenza reagent
    Fei Feng
    Department of Advanced Transdisciplinary Science, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan
    Bioorg Med Chem Lett 20:3772-6. 2010
    ..One of the compounds showed approximately 85% inhibition at the concentration of 400 microM at 4 degrees C...
  79. ncbi request reprint Efficacy of intracerebral immunization against pseudorabies virus in mice
    Jae Ho Shin
    Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, N18 W9 Kita ku, Sapporo, Hokkaido 060 0818, Japan
    Microbiol Immunol 50:823-30. 2006
    ..In mouse models, IC immunization is more effective at inducing a protective immune response against the transneural spread of PRV than SC immunization...
  80. ncbi request reprint The immediate early gene of canine herpesvirus is transcribed through early and late phases
    Masahiro Miyoshi
    Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Vet Med Sci 64:627-31. 2002
    ..The reverse transcription-polymerase chain reaction revealed that the IE promoter was turned off during L phase at a permissive temperature. We, thus, propose to redesignate the IE gene of CHV as CICP4 gene...
  81. pmc Hierarchy among viral RNA (vRNA) segments in their role in vRNA incorporation into influenza A virions
    Yukiko Muramoto
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    J Virol 80:2318-25. 2006
    ..This effect was most prominent with the PB2 vRNA. These findings suggest a hierarchy among vRNA segments for virion incorporation and may imply intersegment association of vRNAs during virus assembly...
  82. pmc Immunogenicity and protective efficacy of replication-incompetent influenza virus-like particles
    Tokiko Watanabe
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Virol 76:767-73. 2002
    ..These results demonstrate the potential of replication-incompetent NS2-knockout VLPs as novel influenza vaccines and perhaps also as vectors to express genes from entirely unrelated pathogens...
  83. pmc Induction of cytotoxic T-lymphocyte and antibody responses against highly pathogenic avian influenza virus infection in mice by inoculation of apathogenic H5N1 influenza virus particles inactivated with formalin
    Toshihiro Sawai
    Department of Pathology, Shiga University of Medical Sciences, Setatsukinowa, Otsu, Japan
    Immunology 124:155-65. 2008
    ....
  84. doi request reprint A vaccine prepared from a non-pathogenic H5N1 avian influenza virus strain confers protective immunity against highly pathogenic avian influenza virus infection in cynomolgus macaques
    Yasushi Itoh
    Department of Pathology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Vaccine 26:562-72. 2008
    ..This demonstrates that the vaccine prepared with the non-pathogenic H5N1 virus from our influenza virus library conferred protective immunity against H5N1 HPAI virus infection to macaques...
  85. ncbi request reprint Influenza A virus with defective M2 ion channel activity as a live vaccine
    Tokiko Watanabe
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI 53706, USA
    Virology 299:266-70. 2002
    ....
  86. ncbi request reprint Serological evidence of transmission of human influenza A and B viruses to Caspian seals (Phoca caspica)
    Kazue Ohishi
    Otsuchi Marine Research Center, Ocean Research Institute, University of Tokyo, Iwate, Japan
    Microbiol Immunol 46:639-44. 2002
    ..Our findings indicate that seal might be a reservoir of both influenza A and B viruses originated from humans...
  87. ncbi request reprint Phylogenetic analysis of hemagglutinin and neuraminidase genes of H9N2 viruses isolated from migratory ducks
    Jin Hua Liu
    Laboratory of Microbiology, College of Veterinary Medicine, China Agricultural University, Beijing, 100094, People s Republic of China
    Virus Genes 27:291-6. 2003
    ..The present results further emphasize the importance of carrying out molecular epidemiological surveillance of H9N2 viruses in wild ducks to obtain more information for the future human influenza pandemics preparedness...
  88. ncbi request reprint Interregional transmission of the internal protein genes of H2 influenza virus in migratory ducks from North America to Eurasia
    Jin Hua Liu
    Laboratory of Microbiology, College of Veterinary Medicine, China Agricultural University, Beijing, 100094, People s Republic of China
    Virus Genes 29:81-6. 2004
    ..The fact that reassortants could be generated in the migratory ducks between North American and Eurasian avian virus lineage further stresses the importance of global surveillance among the migratory ducks...
  89. ncbi request reprint [Round table discussion on highly pathogenic H5N1 avian influenza]
    Yoshiyuki Nagai
    Uirusu 54:123-41. 2004
  90. ncbi request reprint Molecular characterization of the hemagglutinin and neuraminidase genes of H5N1 influenza A viruses isolated from poultry in Vietnam from 2004 to 2005
    Yukiko Muramoto
    International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    J Vet Med Sci 68:527-31. 2006
    ..We found that several groups of highly pathogenic H5N1 avian influenza viruses are circulating among these birds, which suggests that H5N1 viruses of different lineages have been introduced into Vietnam multiple times...
  91. ncbi request reprint Outbreak of highly pathogenic avian influenza in Japan and anti-influenza virus activity of povidone-iodine products
    Hiroshi Ito
    Department of Veterinary Public Health, Faculty of Agriculture, Tottori University, Tottori 680 8553, Japan
    Dermatology 212:115-8. 2006
    ..In the present study, the antiviral activity of PVP-I products against H5, H7 and H9 avian influenza A viruses, which had recently been transmitted to humans, were investigated...
  92. ncbi request reprint Ecology and epidemiology of anthrax in cattle and humans in Zambia
    Victor M Siamudaala
    Zambia Wildlife Authority, Private Bag 1 Chilanga, Zambia
    Jpn J Vet Res 54:15-23. 2006
    ..This may lead to a culminating positive impact on livestock and human health in the southern African region...
  93. ncbi request reprint Architecture of ribonucleoprotein complexes in influenza A virus particles
    Takeshi Noda
    Internal Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Nature 439:490-2. 2006
    ..A selective mechanism of RNP incorporation into virions and the unique organization of the eight RNP segments may be crucial to maintaining the integrity of the viral genome during repeated cycles of replication...
  94. ncbi request reprint Replication and transmission of influenza viruses in Japanese quail
    Natalia V Makarova
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105 2794, USA
    Virology 310:8-15. 2003
    ....
  95. ncbi request reprint Insertion of cellular sequence and RNA recombination in the structural protein coding region of cytopathogenic bovine viral diarrhoea virus
    Makoto Nagai
    Ishikawa Nanbu Livestock Hygiene Service Center, Kanazawa, Ishikawa 920 3101, Japan
    J Gen Virol 84:447-52. 2003
    ..In contrast, the region downstream from the insertion of KS86-1cp showed high identity to KS86-1ncp, but not to Nose. These data reveal that KS86-1cp is a chimeric virus generated by homologous RNA recombination in a calf with MD...
  96. ncbi request reprint The quail and chicken intestine have sialyl-galactose sugar chains responsible for the binding of influenza A viruses to human type receptors
    Chao Tan Guo
    Institute of Bioengineering, Zhejiang Academy of Medical Sciences, 182 Tianmushan Road, Hangzhou 310016, China
    Glycobiology 17:713-24. 2007
    ....
  97. ncbi request reprint JC virus strains indigenous to northeastern Siberians and Canadian Inuits are unique but evolutionally related to those distributed throughout Europe and Mediterranean areas
    Chie Sugimoto
    Laboratory of Viral Infection, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Mol Evol 55:322-35. 2002
    ..Based on the present findings, we discuss ancient human migrations, accompanied by Type A JCVs, across Asia and to Arctic areas of North America...
  98. ncbi request reprint Electron-dense deposition patterns and the outcomes of idiopathic membranous nephropathy in Japanese
    Hitoshi Yokoyama
    Division of Blood Purification, Department of Gastroenterology and Nephrology, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    Med Electron Microsc 35:81-6. 2002
    ....
  99. ncbi request reprint [Guidelines for the management of rapidly progressive glomerulonephritis]
    Hideto Sakai
    Nihon Jinzo Gakkai Shi 44:55-82. 2002
  100. ncbi request reprint Intranasal immunization with formalin-inactivated virus vaccine induces a broad spectrum of heterosubtypic immunity against influenza A virus infection in mice
    Ayato Takada
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, 108 8639, Japan
    Vaccine 21:3212-8. 2003
    ..This approach may overcome limitations in the efficacy of inactivated influenza vaccines and confer potent immunity to humans against viruses with new pandemic potential...
  101. ncbi request reprint Hepatoma-derived growth factor is involved in lung remodeling by stimulating epithelial growth
    Masahide Mori
    Department of Molecular Medicine, Osaka University Graduate University Graduate School of Medicine, Osaka, Japan
    Am J Respir Cell Mol Biol 30:459-69. 2004
    ..These findings suggest that HDGF may be involved in lung remodeling after injury by promoting the proliferation of lung epithelial cells, probably in an autocrine manner...