Mototsugu Kato

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. pmc Preliminary trial of rebamipide for prevention of low-dose aspirin-induced gastric injury in healthy subjects: a randomized, double-blind, placebo-controlled, cross-over study
    Shouko Ono
    Division of Endoscopy, Hokkaido University Hospital, Sapporo 060 8468, Japan
    J Clin Biochem Nutr 45:248-53. 2009
  2. pmc Evaluation of gastrointestinal injury and blood flow of small bowel during low-dose aspirin administration
    Urara Nishida
    Department of Gastroenterology, Hokkaido University Graduate School of Medicine, North 15, West 17, Kita ku, Sapporo, Hokkaido 060 8638, Japan
    J Clin Biochem Nutr 48:245-50. 2011
  3. doi request reprint Changes in endoscopic findings of gastritis after cure of H. pylori infection: multicenter prospective trial
    Mototsugu Kato
    Division of Endoscopy, Hokkaido University Hospital, Sapporo, Hokkaido 060 8468, Japan
    Dig Endosc 25:264-73. 2013
  4. doi request reprint Recent development of gastric cancer prevention
    Mototsugu Kato
    Division of Endoscopy, Hokkaido University Hospital, Department of Cancer Preventive Medicine, Hokkaido University Graduate School of Medicine, North 14, West 5, Kita ku, Sapporo, Hokkaido 060 8468, Japan
    Jpn J Clin Oncol 42:987-94. 2012
  5. doi request reprint Recent knowledge of the relationship between Helicobacter pylori and gastric cancer and recent progress of gastroendoscopic diagnosis and treatment for gastric cancer
    Mototsugu Kato
    Division of Endoscopy, Hokkaido University Hospital North 14, Sapporo, Hokkaido 060 8468, Japan
    Jpn J Clin Oncol 40:828-37. 2010
  6. ncbi request reprint Randomized, double-blind, placebo-controlled crossover trial of famotidine in patients with functional dyspepsia
    M Kato
    Division of Endoscopy, Department of Endoscopy, Hokkaido University Hospital, Sapporo, Hokkaido, Japan
    Aliment Pharmacol Ther 21:27-31. 2005
  7. doi request reprint Pathophysiological classification of functional dyspepsia using a novel drinking-ultrasonography test
    Mototsugu Kato
    Division of Endoscopy, Hokkaido University Hospital, Sapporo, Hokkaido 060 8468 Japan
    Digestion 82:162-6. 2010
  8. doi request reprint Lafutidine prevents low-dose aspirin and loxoprofen induced gastric injury: a randomized, double-blinded, placebo controlled study
    Mototsugu Kato
    Division of Endoscopy, Hokkaido University Hospital, Sapporo, Japan
    J Gastroenterol Hepatol 25:1631-5. 2010
  9. ncbi request reprint Relationship between Helicobacter pylori infection and the prevalence, site and histological type of gastric cancer
    M Kato
    Division of Endoscopy, Hokkaido University Hospital, Sapporo, Japan
    Aliment Pharmacol Ther 20:85-9. 2004
  10. doi request reprint Investigation of gastric and duodenal mucosal defects caused by low-dose aspirin in patients with ischemic heart disease
    Hiroaki Nema
    Department of Gastroenterology, Hokko Memorial Hospital, Hokkaido University Hospital, Sapporo, Hokkaido, Japan
    J Clin Gastroenterol 43:130-2. 2009

Collaborators

Detail Information

Publications153 found, 100 shown here

  1. pmc Preliminary trial of rebamipide for prevention of low-dose aspirin-induced gastric injury in healthy subjects: a randomized, double-blind, placebo-controlled, cross-over study
    Shouko Ono
    Division of Endoscopy, Hokkaido University Hospital, Sapporo 060 8468, Japan
    J Clin Biochem Nutr 45:248-53. 2009
    ..Rebamipide may be useful for preventing low-dose aspirin-induced gastric mucosal injury, especially which confined to the antrum...
  2. pmc Evaluation of gastrointestinal injury and blood flow of small bowel during low-dose aspirin administration
    Urara Nishida
    Department of Gastroenterology, Hokkaido University Graduate School of Medicine, North 15, West 17, Kita ku, Sapporo, Hokkaido 060 8638, Japan
    J Clin Biochem Nutr 48:245-50. 2011
    ..Acetylsalicylic acid administration also caused a decrease in small intestinal blood flow. Contrast-enhanced ultrasonography is useful for evaluation blood flow in the small bowel mucosa...
  3. doi request reprint Changes in endoscopic findings of gastritis after cure of H. pylori infection: multicenter prospective trial
    Mototsugu Kato
    Division of Endoscopy, Hokkaido University Hospital, Sapporo, Hokkaido 060 8468, Japan
    Dig Endosc 25:264-73. 2013
    ..However, change of endoscopic mucosal findings is not fully understood. To clarify the short-term changes of endoscopic mucosal findings after cure of H. pylori infection, a multicenter prospective trial was conducted...
  4. doi request reprint Recent development of gastric cancer prevention
    Mototsugu Kato
    Division of Endoscopy, Hokkaido University Hospital, Department of Cancer Preventive Medicine, Hokkaido University Graduate School of Medicine, North 14, West 5, Kita ku, Sapporo, Hokkaido 060 8468, Japan
    Jpn J Clin Oncol 42:987-94. 2012
    ..We have proposed a program of risk stratification based on the presence of H. pylori infection with or without atrophic gastritis followed by targeted interventions...
  5. doi request reprint Recent knowledge of the relationship between Helicobacter pylori and gastric cancer and recent progress of gastroendoscopic diagnosis and treatment for gastric cancer
    Mototsugu Kato
    Division of Endoscopy, Hokkaido University Hospital North 14, Sapporo, Hokkaido 060 8468, Japan
    Jpn J Clin Oncol 40:828-37. 2010
    ..Because of endoscopic submucosal dissection, endoscopic resection is indicated in a greater number of cases. Although the use of endoscopic treatment for gastric cancer has been increasing steadily, long-term outcome data is necessary...
  6. ncbi request reprint Randomized, double-blind, placebo-controlled crossover trial of famotidine in patients with functional dyspepsia
    M Kato
    Division of Endoscopy, Department of Endoscopy, Hokkaido University Hospital, Sapporo, Hokkaido, Japan
    Aliment Pharmacol Ther 21:27-31. 2005
    ..Histamine 2-receptor antagonists were used as a first therapy against functional dyspepsia. However, few clinical studies with famotidine for functional dyspepsia have been reported...
  7. doi request reprint Pathophysiological classification of functional dyspepsia using a novel drinking-ultrasonography test
    Mototsugu Kato
    Division of Endoscopy, Hokkaido University Hospital, Sapporo, Hokkaido 060 8468 Japan
    Digestion 82:162-6. 2010
    ..We developed a novel drinking-ultrasonography test to combine a drink test with ultrasonography to assess gastric motility and sensory function of FD patients...
  8. doi request reprint Lafutidine prevents low-dose aspirin and loxoprofen induced gastric injury: a randomized, double-blinded, placebo controlled study
    Mototsugu Kato
    Division of Endoscopy, Hokkaido University Hospital, Sapporo, Japan
    J Gastroenterol Hepatol 25:1631-5. 2010
    ..To evaluate the preventive effect of lafutidine on gastric damage caused by LDA alone and by the combination of both LDA and loxoprofen, we conducted a clinical study using healthy volunteers...
  9. ncbi request reprint Relationship between Helicobacter pylori infection and the prevalence, site and histological type of gastric cancer
    M Kato
    Division of Endoscopy, Hokkaido University Hospital, Sapporo, Japan
    Aliment Pharmacol Ther 20:85-9. 2004
    ..To evaluate the relationship between Helicobacter pylori infection and gastric cancer in Japan...
  10. doi request reprint Investigation of gastric and duodenal mucosal defects caused by low-dose aspirin in patients with ischemic heart disease
    Hiroaki Nema
    Department of Gastroenterology, Hokko Memorial Hospital, Hokkaido University Hospital, Sapporo, Hokkaido, Japan
    J Clin Gastroenterol 43:130-2. 2009
    ..Low-dose aspirin is used for secondary prevention of ischemic heart disease and ischemic cerebrovascular disease. Currently, the frequency of gastrointestinal disorder among users of low-dose aspirin is unknown...
  11. doi request reprint Characteristics of magnified endoscopic images of gastric extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue, including changes after treatment
    Shouko Ono
    Division of Endoscopy, Hokkaido University Hospital, Sapporo, Japan
    Gastrointest Endosc 68:624-31. 2008
    ..The utility of magnifying endoscopy for diagnosis of epithelial tumors has been reported, but there are few reports for nonepithelial tumors...
  12. doi request reprint Low-grade dysplasia component in early invasive squamous cell carcinoma of the esophagus
    Yuichi Shimizu
    Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Gastroenterol Hepatol 25:314-8. 2010
    ..If LGD progresses to squamous cell carcinoma, early carcinoma lesions that have such a natural history might contain a remaining LGD component...
  13. doi request reprint Endoscopic resection (endoscopic mucosal resection/ endoscopic submucosal dissection) for superficial esophageal squamous cell carcinoma: current status of various techniques
    Yuichi Shimizu
    Department of Gastroenterology, Hokkaido University Hospital, Sapporo, Japan
    Dig Endosc 25:13-9. 2013
    ..Although there are various knives developed for ESD, the basic techniques for safe and effective ESD are the same...
  14. doi request reprint Immediate acid-suppressing effects of ranitidine hydrochloride and rabeprazole sodium following initial administration and reintroduction: A randomized, cross-over study using wireless pH monitoring capsules
    Shouko Ono
    Division of Endoscopy, Hokkaido University Hospital, Sapporo, Hokkaido 060 8638, Japan
    J Gastroenterol Hepatol 24:639-45. 2009
    ..The objective of this study was to compare the acid-suppressing effects of ranitidine hydrochloride and those of rabeprazole sodium at the first administration and re-administration after withdrawal...
  15. doi request reprint Identification of a high risk gastric cancer group using serum pepsinogen after successful eradication of Helicobacter pylori
    Masahira Haneda
    Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Gastroenterol Hepatol 28:78-83. 2013
    ..Therefore, we aimed to identify a high risk group for gastric cancer using serum pepsinogen after successful eradication of H. pylori...
  16. doi request reprint Frequency of Helicobacter pylori -negative gastric cancer and gastric mucosal atrophy in a Japanese endoscopic submucosal dissection series including histological, endoscopic and serological atrophy
    Shouko Ono
    Division of Endoscopy, Hokkaido University Hospital, Sapporo, Japan
    Digestion 86:59-65. 2012
    ..pylori infection. The aim of this study was to determine the frequency of H. pylori-negative gastric cancer and to clarify relationships with histological atrophy, endoscopic atrophy, and serological atrophy...
  17. ncbi request reprint Long-term treatment of localized gastric marginal zone B-cell mucosa associated lymphoid tissue lymphoma including incidence of metachronous gastric cancer
    Shouko Ono
    Division of Endoscopy, Hokkaido University Hospital, Sapporo, Japan
    J Gastroenterol Hepatol 25:804-9. 2010
    ..However, the risk of metachronous gastric cancer has not been evaluated. In this study, we analyzed long-term outcomes of localized gastric MALT lymphoma including the incidence of metachronous gastric cancer...
  18. ncbi request reprint Improvement in symptoms after H2-receptor antagonist-based therapy for eradication of H pylori infection
    Takeshi Hagiwara
    Department of Gastroenterology, Sapporo Kosei General Hospital, Sapporo, Hokkaido 060 4876, Japan
    World J Gastroenterol 13:3836-40. 2007
    ..To investigate the therapeutic effects of triple therapy combining lafutidine with clarithromycin and amoxicillin on H pylori infection and the resolution of gastroesophageal symptoms after eradication...
  19. ncbi request reprint Polaprezinc (N-(3-aminopropionyl)-L-histidinato zinc) ameliorates dextran sulfate sodium-induced colitis in mice
    Tatsuya Ohkawara
    Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Scand J Gastroenterol 40:1321-7. 2005
    ..The aim of this study was to investigate the effect of polaprezinc on dextran sulfate (DSS)-induced colitis in mice...
  20. ncbi request reprint Endoscopic submucosal dissection for treatment of early stage hypopharyngeal carcinoma
    Yuichi Shimizu
    Division of Endoscopy and Department of Otolaryngology, Hokkaido University Hospital, Sapporo, Japan
    Gastrointest Endosc 64:255-9; discussion 260-2. 2006
    ..Early detection of hypopharyngeal carcinoma is increasingly possible and patients with such early lesions can be treated with endoscopic resection...
  21. ncbi request reprint Histologic results of EMR for esophageal lesions diagnosed as high-grade intraepithelial squamous neoplasia by endoscopic biopsy
    Yuichi Shimizu
    Division of Endoscopy, Hokkaido University Hospital, Kitaku, Sapporo, Japan
    Gastrointest Endosc 63:16-21. 2006
    ..The purpose of this study was to perform EMR for such lesions and to determine the actual tumor stage in patients with complete resection and the outcomes after EMR...
  22. doi request reprint Comparison of gastric relaxation and sensory functions between functional dyspepsia and healthy subjects using novel drinking-ultrasonography test
    Tamotsu Hata
    Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Digestion 87:34-9. 2013
    ..We developed a novel drinking-ultrasonography test to combine a drink test with ultrasonography to assess gastric motility and sensory function of FD patients...
  23. ncbi request reprint Resistance to experimental colitis depends on cytoprotective heat shock proteins in macrophage migration inhibitory factor null mice
    Tatsuya Ohkawara
    Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Kita15, Nishi7, Kita ku, Sapporo 060 8638, Japan
    Immunol Lett 107:148-54. 2006
    ..Our findings in this study provide more information in the role of MIF in colitis...
  24. ncbi request reprint Endoscopic clip application for closure of esophageal perforations caused by EMR
    Yuichi Shimizu
    Third Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    Gastrointest Endosc 60:636-9. 2004
    ..This study evaluated the results of endoscopic clip application for treatment of perforations caused by EMR in patients with esophageal carcinoma...
  25. ncbi request reprint Geranylgeranylacetone protects mice from dextran sulfate sodium-induced colitis
    Tatsuya Ohkawara
    Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Scand J Gastroenterol 40:1049-57. 2005
    ..We investigated the therapeutic effects of oral administration of GGA on dextran sulfate sodium (DSS)-induced colitis in mice...
  26. ncbi request reprint EMR combined with chemoradiotherapy: a novel treatment for superficial esophageal squamous-cell carcinoma
    Yuichi Shimizu
    Division of Endoscopy, Hokkaido University Medical Hospital, Sapporo, Japan
    Gastrointest Endosc 59:199-204. 2004
    ..EMR was performed for the purpose of complete local tumor control and chemoradiotherapy was performed for regional and distant control...
  27. doi request reprint Target biopsy using magnifying endoscopy in clinical management of gastric mucosa-associated lymphoid tissue lymphoma
    Shouko Ono
    Division of Endoscopy, Hokkaido University Hospital, Sapporo, Japan
    J Gastroenterol Hepatol 26:1133-8. 2011
    ..In this study, we investigated the diagnostic efficacy of magnified endoscopic images for target biopsy and evaluation of clinical remission...
  28. doi request reprint Investigation of gastroduodenal mucosal injuries caused by low-dose aspirin therapy in patients with cerebral infarction
    Hiroaki Nema
    Department of Gastroenterology, Teishinkai Hospital, Sapporo, Japan
    J Gastroenterol Hepatol 25:S119-21. 2010
    ..In the present study, endoscopic examination was performed to investigate the frequency of gastroduodenal injuries associated with low-dose aspirin in patients with cerebrovascular disease...
  29. doi request reprint Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial
    Kazutoshi Fukase
    Department of Gastroenterology, Yamagata Prefectural Central Hospital, Yamagata, Japan
    Lancet 372:392-7. 2008
    ..Our aim was to investigate the prophylactic effect of H pylori eradication on the development of metachronous gastric carcinoma after endoscopic resection for early gastric cancer...
  30. doi request reprint Guidelines for the management of Helicobacter pylori infection in Japan: 2009 revised edition
    Masahiro Asaka
    Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Helicobacter 15:1-20. 2010
    ..pylori and gastric cancer has been demonstrated more clearly. Accordingly, the committee of the Japanese Society for Helicobacter Research has revised the guidelines for diagnosis and treatment of H. pylori infection in Japan...
  31. ncbi request reprint [After endoscopic treatment of early stage gastric cancer]
    Mototsugu Kato
    Division of Endoscopy, Hokkaido University Hospital
    Nihon Rinsho 71:1429-35. 2013
    ..Because H. pylori eradication after endoscopic treatment of early gastric cancer have been covered under public health insurance, positive eradication therapy for H. pylori infection is expected to reduce metachronous cancer...
  32. ncbi request reprint Helicobacter pylori: longer survival in deep ground water and sea water than in a nutrient-rich environment
    Kohei Konishi
    Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    APMIS 115:1285-91. 2007
    ..01). Thus, natural waters were found to be more conducive to H. pylori survival than a nutrient-rich medium...
  33. doi request reprint Clinicopathological analysis of early-stage gastric cancers detected after successful eradication of Helicobacter pylori
    Keiko Yamamoto
    Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Helicobacter 16:210-6. 2011
    ..There is a lack of study about gastric cancers in eradicated patients. To clarify the characteristics of gastric cancers detected after H. pylori eradication, we analyzed the clinicopathological features of these cancers...
  34. ncbi request reprint Outcomes and predictive factors of "not self-completion" in gastric endoscopic submucosal dissection for novice operators
    Shouko Ono
    Division of Endoscopy, Hokkaido University Hospital, Nishi 7, Kita 15, Kita ku, Sapporo, 060 8638, Japan
    Surg Endosc 27:3577-83. 2013
    ..In this study, predictive factors of gastric neoplasms in which novices could not finish ESD by self-completion were evaluated...
  35. doi request reprint Endoscopic in vivo cellular imaging of superficial squamous cell carcinoma of the head and neck by using an integrated endocytoscopy system (with video)
    Yuichi Shimizu
    Department of Gastroenterology, Hokkaido University Hospital, Sapporo, Japan
    Gastrointest Endosc 78:351-8. 2013
    ..An endocytoscopy system has been reported to enable optical biopsy of an esophageal lesion...
  36. ncbi request reprint [Long-term follow-up after H. pylori eradication]
    Mototsugu Kato
    Department of Endoscopy, Hokkaido University Hospital
    Nihon Rinsho 63:491-4. 2005
  37. pmc Evaluation of small bowel blood flow in healthy subjects receiving low-dose aspirin
    Urara Nishida
    Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo 060 8648, Japan
    World J Gastroenterol 17:226-30. 2011
    ..To investigate the relationship between low-dose aspirin-induced small bowel mucosal damage and blood flow, and the effect of rebamipide...
  38. ncbi request reprint [Rapid urease test]
    Mototsugu Kato
    Department of Endoscopy, Hokkaido University Graduate School of Medicine
    Nihon Rinsho 61:72-8. 2003
    ..RUT is useful for diagnosis of H. pylori infection before and after eradication treatment. However, the sensitivity of RUT is comparatively low within 6 months after completion of eradication...
  39. ncbi request reprint [Position of NSAIDs in causal factors of peptic ulcer]
    Mototsugu Kato
    Division of Endoscopy, Hokkaido University Hospital
    Nihon Rinsho 65:1760-7. 2007
    ..Its mechanism is able to induce gastroduodenal ulcer. Since the elderly population in Japan is rising, the number of patients who need NSAIDs treatment is expected to increase in near future...
  40. ncbi request reprint Endoscopic diagnosis of early squamous neoplasia of the esophagus with iodine staining: high-grade intra-epithelial neoplasia turns pink within a few minutes
    Yuichi Shimizu
    Division of Endoscopy, Hokkaido University Hospital, Sapporo, Japan
    J Gastroenterol Hepatol 23:546-50. 2008
    ....
  41. doi request reprint Endoscopic survey of low-dose-aspirin-induced gastroduodenal mucosal injuries in patients with ischemic heart disease
    Hiroaki Nema
    Department of Gastroenterology, Hokko Memorial Hospital, Sapporo, Japan
    J Gastroenterol Hepatol 23:S234-6. 2008
    ..In the present study endoscopic examination was performed to investigate the frequency of gastroduodenal injuries associated with low-dose aspirin in patients with ischemic heart disease (IHD)...
  42. ncbi request reprint Relationship between histopathologic gastritis and mucosal microvascularity: observations with magnifying endoscopy
    Souichi Nakagawa
    Department of Gastroenterology and Division of Endoscopy, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Gastrointest Endosc 58:71-5. 2003
    ..The purpose of this study was to determine the usefulness of magnifying endoscopy for the diagnosis of Helicobacter pylori-induced histopathologic gastritis...
  43. doi request reprint Macrophage migration inhibitory factor contributes to development of nonsteroidal anti-inflammatory drugs-induced gastric injury in mice
    Tatsuya Ohkawara
    Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Sapporo 060 8638, Japan
    Int Immunopharmacol 11:418-23. 2011
    ..Our results suggest that MIF is essential for the development of gastric injury-induced by NSAIDs...
  44. ncbi request reprint Molecular cloning of p53 cDNA of Mongolian gerbil and establishment of yeast p53 functional assay system
    Jun Ishizuka
    Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Institute for Genetic Medicine, Hokkaido University Sapporo, Japan
    Helicobacter 8:81-9. 2003
    ..Mutation of the p53 gene is one of the most common steps in gastric carcinogenesis. In this study, we aimed to clone the p53 gene of the Mongolian gerbil and detect the functional mutations in H. pylori-infected animals...
  45. ncbi request reprint [Significance of H. pylori eradication in treatment and prevention for low-dose aspirin induced gastric ulcer of elderly]
    Mototsugu Kato
    Division of Endoscopy, Hokkaido University Hospital
    Nihon Rinsho 68:2089-95. 2010
    ..However, H. pylori eradication is not recommended in NSAIDs user because of no ulcer suppression and ulcer healing delay. In prevention of LDA induced ulcer recurrence, H. pylori eradication plus PPI treatment are necessary...
  46. ncbi request reprint [Problem of 13C-urea breath test in the diagnosis of H. pylori after eradication]
    Mototsugu Kato
    Department of Endoscopy, Hokkaido University Hospital
    Nihon Rinsho 63:221-5. 2005
  47. ncbi request reprint [Stomach after endoscopic mucosal resection of early gastric cancer for which H. pylori eradication is recommended]
    Mototsugu Kato
    Department of Endoscopy, Hokkaido University Hospital
    Nihon Rinsho 63:275-9. 2005
  48. ncbi request reprint Human intestinal spirochetosis is significantly associated with sessile serrated adenomas/polyps
    Saori Omori
    Division of Endoscopy, Hokkaido University Hospital, Sapporo, Hokkaido, Japan Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan
    Pathol Res Pract 210:440-3. 2014
    ..1% (14/172). Our SSA/P series were associated with a remarkably higher rate of HIS than controls or than previously reported. This is the first report to provide evidence for potential association between HIS and SSA/Ps. ..
  49. ncbi request reprint [Adverse effects of NSAIDs in treatment of rheumatoid arthritis]
    Mototsugu Kato
    Division of Endoscopy, Hokkaido University Hospital
    Nihon Rinsho 63:560-5. 2005
  50. doi request reprint Endoscopic diagnosis of early neoplasia of the esophagus with narrow band imaging: correlations among background coloration and iodine staining findings
    Masakazu Takahashi
    Department of Gastroenterology and Hepatology, Hokkaido University Hospital, Sapporo, Japan
    J Gastroenterol Hepatol 29:762-8. 2014
    ..The diagnostic usefulness of BGC findings for differentiating high-grade intraepithelial neoplasia from low-grade intraepithelial neoplasia was evaluated...
  51. ncbi request reprint Follow-up survey of a large-scale multicenter, double-blind study of triple therapy with lansoprazole, amoxicillin, and clarithromycin for eradication of Helicobacter pylori in Japanese peptic ulcer patients
    Masahiro Asaka
    Third Department of Internal Medicine, Hokkaido University School of Medicine, North 15, West 7, Kita ku, Sapporo 036 8638, Japan
    J Gastroenterol 38:339-47. 2003
    ..These patients had previously participated in a large-scale multicenter trial of triple therapy with lansoprazole (LPZ)/amoxicillin (AMPC)/clarithromycin (CAM) for eradication of H. pylori...
  52. ncbi request reprint [Immunological rapid urease test]
    Mototsugu Kato
    Department of Endoscopy, Hokkaido University Hospital
    Nihon Rinsho 62:470-6. 2004
    ..The utility of immunological rapid urease test was evaluated in some clinical studies...
  53. doi request reprint Efficacy of carbon dioxide-insufflating colonoscopy in patients with irritable bowel syndrome: a randomized double-blind study
    Aki Imai
    Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Gastroenterol Hepatol 27:1623-8. 2012
    ..However, there have been no studies in which CO(2) insufflation in colonoscopy of patients with irritable bowel syndrome (IBS) was investigated...
  54. ncbi request reprint [The significance of H. pylori eradication in NSAIDs ulcer]
    Mototsugu Kato
    Division of Endoscopy, Hokkaido University Hospital
    Nihon Rinsho 69:1049-56. 2011
    ..However, H. pylori eradication is not recommended in NSAIDs user because of no ulcer suppression and ulcer healing delay. In prevention of NSAIDs induced ulcer recurrence, H. pylori eradication plus PPI treatment is necessary...
  55. ncbi request reprint [Helicobacter pylori IgG antibody, urea breath test, Helicobacter pylori antigen in the stool]
    Mototsugu Kato
    Department of Endoscopy, Hokkaido University Hospital
    Nihon Rinsho 63:175-9. 2005
  56. pmc Comparative study of therapeutic effects of PPI and H2RA on ulcers during continuous aspirin therapy
    Hiroaki Nema
    Department of Internal Medicine, Teishinkai Hospital, North 44, East 8, Higashi ku, Sapporo, Hokkaido 007 0844, Japan
    World J Gastroenterol 16:5342-6. 2010
    ..To compare the therapeutic effects of proton pump inhibitors (PPI) and histamine 2 receptor antagonists (H2RA) on gastroduodenal ulcers under continuous use of low-dose aspirin...
  57. ncbi request reprint New method for long-term monitoring of intragastric pH
    Shouko Ono
    Division of Endoscopy, Hokkaido University Hospital Nishi 5, Kita 14, Kita ku, Sapporo 060 8648, Japan
    World J Gastroenterol 13:6410-3. 2007
    ..Consecutive monitoring of intragastric pH using the Bravo capsule...
  58. ncbi request reprint Antigen retrieval trial for post-embedding immunoelectron microscopy by heating with several unmasking solutions
    Nagahito Saito
    Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Histochem Cytochem 51:989-94. 2003
    ..We suggest that the antigen retrieval method should be applied for routine use even by in post-embedding immunogold electron microscopy...
  59. ncbi request reprint [Diagnostic imaging of NSAID ulcers]
    Shouko Ono
    Division of Endoscopy, Hokkaido University Hospital
    Nihon Rinsho 65:1792-800. 2007
    ..In conclusion, characteristic images of gastrointestinal injuries induced by NSAIDs are multiple erosions and ulcers with bleeding without symptoms. It is most important asking about use of NSAIDs if we see such endoscopic images...
  60. ncbi request reprint Plural light chains in a single plasma cell of a monoclonal gammopathy undetermined significance case: an ultrastructural study
    Nagahito Saito
    Gastroenterology and Hematology Section, Hokkaido University Graduate School of Internal Medicine, Sapporo, Japan
    Hum Cell 20:10-4. 2007
    ..This is the first report in the world of a monoclonal gammopathy of undetermined significance producing plural light chains with the same heavy chain...
  61. ncbi request reprint [Endoscopic examination including magnifying endoscopy for diagnosis of GERD]
    Mototsugu Kato
    Division of Endoscopy, Hokkaido University Hospital
    Nihon Rinsho 65:865-71. 2007
    ..Magnifying endoscopic observation of IPCLs is useful for diagnosis of NERD which cannot be visualized by conventional endoscopy...
  62. ncbi request reprint A multicenter, double-blind study on triple therapy with lansoprazole, amoxicillin and clarithromycin for eradication of Helicobacter pylori in Japanese peptic ulcer patients
    M Asaka
    Third Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    Helicobacter 6:254-61. 2001
    ..0001 for both). CONCLUSION: A satisfactorily high H. pylori eradication rate was obtained in Japanese ulcer patients with the triple therapy regimen consisting of LPZ 30 mg, AMPC 750 mg, and CAM 200 mg b.i.d...
  63. ncbi request reprint Recurrent peptic ulcers in patients following successful Helicobacter pylori eradication: a multicenter study of 4940 patients
    Hiroto Miwa
    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
    Helicobacter 9:9-16. 2004
    ..The aim of this study is to describe the recurrence rate and specific features of peptic ulcers after cure of H. pylori infection...
  64. ncbi request reprint [Role of H. pylori infection in gastric cancer]
    Masahiro Asaka
    Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Nihon Shokakibyo Gakkai Zasshi 105:337-43. 2008
  65. doi request reprint Strategy for eliminating gastric cancer in Japan
    Masahiro Asaka
    Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Helicobacter 15:486-90. 2010
    ..It would probably reduce the incidence of gastric cancer by more than 80-90% within 10 years. The Japanese government should take the initiative to implement this strategy as soon as possible...
  66. ncbi request reprint Up-regulated Smad5 mediates apoptosis of gastric epithelial cells induced by Helicobacter pylori infection
    Tomokazu Nagasako
    Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    J Biol Chem 278:4821-5. 2003
    ..These results suggest that Smad5 is up-regulated in gastric epithelial cells through the presence of cagPAI of H. pylori and that Smad5 mediates apoptosis of gastric epithelial cells induced by H. pylori infection...
  67. ncbi request reprint [Characteristics of gastric cancer detected after successful eradication of H. pylori]
    Mototsugu Kato
    Department of Endoscopy, Hokkaido University Hospital
    Nihon Rinsho 70:1795-801. 2012
    ..pylori eradication were different from those of gastric cancers in patients with H. pylori infection. H. pylori eradication is thought to suppress intestinalization during the development of gastric cancer...
  68. ncbi request reprint Spontaneous resolution of cap polyposis: case report
    Tatsuya Ohkawara
    Department of Gastroenterology and Hematology, Division of Endoscopy, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Gastrointest Endosc 57:599-602. 2003
  69. ncbi request reprint [The effect of H. pylori eradication against prevention of gastric cancer]
    Katsuhiro Mabe
    Department of Endoscopy, Hokkaido University Hospital
    Nihon Rinsho 70:1726-30. 2012
    ..pylori eradication. The strategy for elimination of gastric cancer in Japan should consist of H. pylori eradication as primary prevention and surveillance of gastric cancer using endoscopy as secondary prevention...
  70. ncbi request reprint Changes in the plasma level of macrophage migration inhibitory factor in ulcerative colitis patients treated with selective granulocyte and monocyte apheresis
    Tatsusya Ohkawara
    Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Intern Med 46:1821-2. 2007
  71. ncbi request reprint Coccoid formation as a mechanism of species-preservation in Helicobacter pylori: an ultrastructural study
    Nagahito Saito
    Department of Gastroenterology and Hematology Section Hokkaido University Graduate School of Medicine, Sapporo, 060 8638, Japan
    Hokkaido Igaku Zasshi 83:291-5. 2008
    ..In other words, the coccoid formation of H. pylori means not only the dying or the dormant condition but also a horizontal gene transfer processes with a positive significance for species-preservation under environmental stress...
  72. ncbi request reprint Ultrastructural observation of Helicobacter pylori in glucose-supplemented culture media
    Fujio Sato
    Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Kita 15 jou, Nishi 7 chome, Kita ku, Sapporo, Japan
    J Med Microbiol 52:675-9. 2003
    ..The optimal glucose concentration for H. pylori culture in this liquid medium culture experiment was approximately 300 mM...
  73. ncbi request reprint Prevention of gastric cancer by Helicobacter pylori eradication
    Masahiro Asaka
    Department of Gastroenterology, Internal Medicine, Hokkaido University Graduate School of Medicine, Sapporo
    Intern Med 49:633-6. 2010
    ..pylori infection should be treated by eradication therapy following this study. New evidence obtained from our study in Japan may be helpful for the prevention and eventually elimination of gastric cancer worldwide...
  74. ncbi request reprint Removal of mucus for ultrastructural observation of the surface of human gastric epithelium using pronase
    Nagahito Saito
    Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Helicobacter 7:112-5. 2002
    ..We studied the nonmechanical method for removal of mucus layer of gastric epithelium using pronase...
  75. doi request reprint Relationship between diffusion-weighted magnetic resonance imaging and histological tumor grading of hepatocellular carcinoma
    Mitsuru Nakanishi
    Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Ann Surg Oncol 19:1302-9. 2012
    ..The aim of this study was to determine the usefulness of diffusion-weighted magnetic resonance imaging (DWI) for histological tumor grading and preoperative prediction of early HCC recurrence within 6 months of operation...
  76. ncbi request reprint [Guideline for diagnosis and treatment of Helicobacter pylori infection]
    Mototsugu Kato
    Division of Endoscopy, Hokkaido University Hospital
    Nihon Rinsho 65:299-304. 2007
  77. ncbi request reprint [Gastric ulcer and Helicobacter pylori in the elderly population]
    Shouko Ono
    Division of Endoscopy, Hokkaido University Hospital
    Nihon Rinsho 68:1978-82. 2010
    ..Eradication therapy is recommended for elderly patients as for as non-elderly patients, and antacids are administered to patients who are negative for H. pylori or have a relapse of ulcers...
  78. ncbi request reprint Efficacy of triple therapy with rabeprazole for Helicobacter pylori infection and CYP2C19 genetic polymorphism
    K Hokari
    Department of Internal Medicine III, Hokkaido University School of Medicine, Sapporo, Japan
    Aliment Pharmacol Ther 15:1479-84. 2001
    ..pylori infection, and the H. pylori eradication rate is not affected by CYP2C19 genetic polymorphism...
  79. doi request reprint Effects of preoperative administration of omeprazole on bleeding after endoscopic submucosal dissection: a prospective randomized controlled trial
    S Ono
    Hokkaido University Hospital, Sapporo, Japan
    Endoscopy 41:299-303. 2009
    ..Our aim was to evaluate the benefit of starting PPI treatment 1 day before ESD to prevent bleeding after the procedure...
  80. ncbi request reprint 13C-Urea breath test, using a new compact nondispersive isotope-selective infrared spectrophotometer: comparison with mass spectrometry
    Mototsugu Kato
    Division of Endoscopy, Hokkaido University Hospital, North 14, West 5, Kita ku, Sapporo 060 8648, Japan
    J Gastroenterol 39:629-34. 2004
    ..The objective of this study was to examine the diagnostic performance of the (13)C-UBT, using the UBiT-IR300...
  81. ncbi request reprint Effective esophageal balloon dilation for esophageal stenosis in recessive dystrophic epidermolysis bullosa
    T Okada
    Department of Pediatric Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Eur J Pediatr Surg 16:115-9. 2006
    ..The literature on such injuries is reviewed here, and the problems associated with the treatment of children with esophageal stenosis associated with RDEB are discussed...
  82. ncbi request reprint Treatment of a Gilbert's syndrome patient with irinotecan, leucovorin and 5-fluorouracil
    Y Komatsu
    Dept of Gastroenterology, Hokkaido University School of Medicine, Sapporo City, Hokkaido, Japan
    J Chemother 17:111-4. 2005
    ..We again administered irinotecan but at reduced dose (25 mg/m2). Four courses of this modified IFL were administered safely and the response was favorable...
  83. pmc Transgenic over-expression of macrophage migration inhibitory factor renders mice markedly more susceptible to experimental colitis
    T Ohkawara
    Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Clin Exp Immunol 140:241-8. 2005
    ..Interestingly, the corticosterone level remained unchanged in MIF transgenic mice. MIF enhances DSS-induced colitis, in part via neutrophil accumulation and inhibition of glucocorticoid bioactivity...
  84. ncbi request reprint Attributable risk of H. pylori in peptic ulcer disease: does declining prevalence of infection in general population explain increasing frequency of non-H. pylori ulcers?
    T Sugiyama
    Third Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    Dig Dis Sci 46:307-10. 2001
    ..This suggests that the apparent increase in frequency of non-H. pylori ulcers in the United States is not simply due to the declining prevalence of infection. Other explanations for non-H. pylori ulcers should be sought...
  85. doi request reprint Magnifying endoscopy with narrow band imaging for predicting the invasion depth of superficial esophageal squamous cell carcinoma
    K Goda
    Department of Endoscopy, The Jikei University School of Medicine, Minato ku, Tokyo, Japan
    Dis Esophagus 22:453-60. 2009
    ..Magnifying endoscopy with narrow band imaging may have potential to reduce overestimation risks of non-magnifying high-resolution endoscopy or high-frequency endoscopic ultrasonography...
  86. doi request reprint Magnified endoscopic images of gastric MALT lymphoma before and after treatment
    S Ono
    Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Endoscopy 39:E328. 2007
  87. ncbi request reprint High-dose ecabet sodium improves the eradication rate of helicobacter pylori in dual therapy with lansoprazole and amoxicillin
    H Kagaya
    Department of Gastroenterolgy and Hematology, Hokkaido University, Graduate School of Medicine, Sapporo, Japan
    Aliment Pharmacol Ther 14:1523-7. 2000
    ..The additive effect of ecabet sodium in combination with dual therapy on Helicobacter pylori eradication was evaluated...
  88. doi request reprint Long-term outcome after endoscopic resection in patients with hypopharyngeal carcinoma invading the subepithelium: a case series
    Y Shimizu
    Third Department of Internal Medicine, Hokkaido University Hospital, Sapporo, Japan
    Endoscopy 41:374-6. 2009
    ..The results of this study suggest that hypopharyngeal carcinoma with slight invasion to the subepithelium can be successfully treated by endoscopic resection...
  89. doi request reprint Step-up therapy with biphasic insulin aspart-70/30--Sapporo 1-2-3 study
    N Yoshioka
    Department of Medicine II, Hokkaido University Graduate School of Medicine, Kita 15 jyo, Nishi 7 cho me, Kita ku, Sapporo, Hokkaido, 060 8638, Japan
    Diabetes Res Clin Pract 85:47-52. 2009
    ....
  90. ncbi request reprint A novel A97P amino acid substitution in alpha-galactosidase A leads to a classical Fabry disease with cardiac manifestations
    K Kimura
    Department of Dermatology, Hokkaido University Graduate School of Medicine, N 15, W 7, Kita ku, Sapporo, 060 8638, Japan
    Br J Dermatol 147:545-8. 2002
    ..Fabry disease results from a genetic deficiency of alpha-galactosidase A (GLA) activity. Phenotype-genotype correlations in this condition have not as yet been fully elucidated...
  91. ncbi request reprint Delay of gastric emptying measured by 13C-acetate breath test in neurologically impaired children with gastroesophageal reflux
    T Okada
    Department of Pediatric Surgery, Third Internal Medicine, Endoscopy, First Surgery, Hokkaido University School of Medicine, Sapporo, Japan
    Eur J Pediatr Surg 15:77-81. 2005
    ..0045). Gastric emptying studies can be easily and reliably carried out in children with NI using (13)C- ABT. We showed that we were able to determine the gastric emptying rate by (13)C- ABT in patients with GER due to NI...
  92. ncbi request reprint Head and neck cancer arising after endoscopic mucosal resection for squamous cell carcinoma of the esophagus
    Y Shimizu
    Division of Endoscopy, Hokkido University Medical Hospital, Sapporo, Japan
    Endoscopy 35:322-6. 2003
    ....
  93. ncbi request reprint Helicobacter pylori infection in two areas in Japan with different risks for gastric cancer
    A Nobuta
    Gastroenterology Section, Department of Internal Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Aliment Pharmacol Ther 20:1-6. 2004
    ..We evaluated the relationship between Helicobacter pylori and various factors associated with gastric cancer in two areas in Japan with different risks for mortality due to gastric cancer...
  94. doi request reprint Phase I study of concurrent real-time tumor-tracking thoracic radiation therapy with paclitaxel and carboplatin in locally advanced non-small cell lung cancer
    Jun Sakakibara-Konishi
    First Department of Medicine, Hokkaido University School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    Lung Cancer 74:248-52. 2011
    ..This study was conducted to determine the maximum tolerated dose (MTD) and recommended dose (RD) of paclitaxel in combination with carboplatin and concurrent real-time tumor-tracking thoracic radiation therapy (thoracic RTRT)...
  95. ncbi request reprint Overexpression of the oncoprotein prothymosin alpha triggers a p53 response that involves p53 acetylation
    Takahiko Kobayashi
    Hokkaido University Medical Hospital, Primary Care Medicine, Sapporo, Japan
    Cancer Res 66:3137-44. 2006
    ..Our findings indicate that overexpressed PTMA elicits a p53 response that involves p53 acetylation...
  96. ncbi request reprint [Gastroesophageal reflux disease (GERD). Barrett esophagus]
    Mototsugu Kato
    Department of Endoscopy, Hokkaido University Hospital
    Nihon Rinsho 67:2357-65. 2009
    ..The increase in symptoms of GERD rarely occurs after eradication of H. pylori. Therefore, the presence of reflux esophagitis is not an impediment to performing eradication therapy...
  97. ncbi request reprint In vitro induction of resistance to metronidazole, and analysis of mutations in rdxA and frxA genes from Helicobacter pylori isolates
    Luis Perez Aldana
    Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Infect Chemother 11:59-63. 2005
    ..The results after the in vitro induction of resistance to metronidazole suggested the presence of additional metronidazole resistance mechanisms, other than mutations of the rdxA and/or frxA genes...
  98. doi request reprint Efficacy of therapy for advanced hepatocellular carcinoma: intra-arterial 5-fluorouracil and subcutaneous interferon with image-guided radiation
    Makoto Chuma
    Department of Gastroenterology and Hematology, Hokkaido University, Sapporo, Japan
    J Gastroenterol Hepatol 26:1123-32. 2011
    ..To evaluate the efficacy of intra-arterial 5-fluorouracil (5-FU) and subcutaneous interferon (IFN) combined with image-guided radiation therapy (IGRT) in advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT)...
  99. ncbi request reprint Amelioration of dextran sulfate sodium-induced colitis by anti-macrophage migration inhibitory factor antibody in mice
    Tatsuya Ohkawara
    Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Gastroenterology 123:256-70. 2002
    ....
  100. ncbi request reprint Atrophic gastritis and intestinal metaplasia in Japan: results of a large multicenter study
    M Asaka
    Third Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    Helicobacter 6:294-9. 2001
    ..The high prevalence of the precursor lesion, atrophic gastritis with intestinal metaplasia, among those with H. pylori infection suggests that the risk of development of early gastric cancer will continue to remain high in Japan...
  101. pmc DNA vaccination targeting macrophage migration inhibitory factor prevents murine experimental colitis
    T Ohkawara
    Hokkaido Information University, and Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Clin Exp Immunol 163:113-22. 2011
    ..Our results suggest that immunization with helper T epitope DNA-vaccine targeting MIF may be a useful approach for the treatment of colitis including inflammatory bowel diseases...