Satoru Kase

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. pmc Tissue factor expression in human pterygium
    Ryo Ando
    Laboratory of Ocular Cell Biology and Visual Science, Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Mol Vis 17:63-9. 2011
  2. pmc Ectopic cilia: a histopathological study
    Keitaro Hase
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Case Rep Dermatol 4:37-40. 2012
  3. pmc Abnormalities of fundus autofluorescence in pigmented paravenous chorioretinal atrophy
    Yuki Hashimoto
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Nishi 7, Kita 15, Kita ku, Sapporo 060 8638, Japan
    Open Ophthalmol J 6:125-8. 2012
  4. ncbi request reprint Spontaneous regression of IgG4-related dacryoadenitis
    Satoru Kase
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Nishi 7, Kita 15, Kita ku, Sapporo, 060 8638, Japan
    Mod Rheumatol 23:1018-21. 2013
  5. ncbi request reprint Expression of αB-crystallin and vascular endothelial growth factor in conjunctival squamous cell carcinoma
    Zhenyu Dong
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, n7, W15, Kita ku, Sapporo, Hokkaido 060 8638, Japan
    Anticancer Res 33:3745-51. 2013
  6. ncbi request reprint IgG4-related inflammation of the orbit simulating malignant lymphoma
    Satoru Kase
    Department of Ophthalmology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Anticancer Res 33:2779-83. 2013
  7. doi request reprint Expression of vascular endothelial growth factor in eyes with Coats' disease
    Satoru Kase
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Invest Ophthalmol Vis Sci 54:57-62. 2013
  8. doi request reprint Expression of α-crystallin in the retina of human sympathetic ophthalmia
    Satoru Kase
    Department of Ophthalmology, Laboratory of Ocular Cell Biology and Visual Science, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Mol Med Rep 5:395-9. 2012
  9. pmc Expression of erythropoietin receptor in human epiretinal membrane of proliferative diabetic retinopathy
    Satoru Kase
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, N15 W7, Kita ku, Sapporo 060 8638 Japan
    Br J Ophthalmol 91:1376-8. 2007
  10. ncbi request reprint Immunolocalization of cyclin D1 in the developing lens of c-maf -/- mice
    Satoru Kase
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, N15 W7, Kita ku, Sapporo 060 8638, Japan
    Acta Histochem 107:469-72. 2006

Detail Information

Publications85

  1. pmc Tissue factor expression in human pterygium
    Ryo Ando
    Laboratory of Ocular Cell Biology and Visual Science, Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Mol Vis 17:63-9. 2011
    ..In this study, we analyzed the expression and immunolocalization of TF in pterygial and normal conjunctival tissues of humans...
  2. pmc Ectopic cilia: a histopathological study
    Keitaro Hase
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Case Rep Dermatol 4:37-40. 2012
    ..While anterior ectopic cilia are congenital, ectopic cilia in the palpebral conjunctiva may be acquired, and these aberrant cilia are associated with crypts of Henle and chronic inflammation...
  3. pmc Abnormalities of fundus autofluorescence in pigmented paravenous chorioretinal atrophy
    Yuki Hashimoto
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Nishi 7, Kita 15, Kita ku, Sapporo 060 8638, Japan
    Open Ophthalmol J 6:125-8. 2012
    ..FAF is a useful examination in PPCRA, which can noninvasively demonstrate the distribution of deficit and dysfunction of retinal pigment epithelium...
  4. ncbi request reprint Spontaneous regression of IgG4-related dacryoadenitis
    Satoru Kase
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Nishi 7, Kita 15, Kita ku, Sapporo, 060 8638, Japan
    Mod Rheumatol 23:1018-21. 2013
    ..This case highlights the potential of spontaneous improvement in IgG4-related dacryoadenitis, indicating that careful observation may be one of the therapeutic options for such patients. ..
  5. ncbi request reprint Expression of αB-crystallin and vascular endothelial growth factor in conjunctival squamous cell carcinoma
    Zhenyu Dong
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, n7, W15, Kita ku, Sapporo, Hokkaido 060 8638, Japan
    Anticancer Res 33:3745-51. 2013
    ..To examine the expression of αB-crystallin and vascular endothelial growth factor (VEGF) in conjunctival squamous cell carcinoma (CSCC)...
  6. ncbi request reprint IgG4-related inflammation of the orbit simulating malignant lymphoma
    Satoru Kase
    Department of Ophthalmology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Anticancer Res 33:2779-83. 2013
    ..Oral prednisolone combined with radiotherapy is an effective treatment for patients with IgG4-related ophthalmic disease simulating EMZL...
  7. doi request reprint Expression of vascular endothelial growth factor in eyes with Coats' disease
    Satoru Kase
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Invest Ophthalmol Vis Sci 54:57-62. 2013
    ..To examine the expression of vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR)-2 in enucleated eyes with Coats' disease...
  8. doi request reprint Expression of α-crystallin in the retina of human sympathetic ophthalmia
    Satoru Kase
    Department of Ophthalmology, Laboratory of Ocular Cell Biology and Visual Science, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Mol Med Rep 5:395-9. 2012
    ..This may play a protective role in the suppression of photoreceptor apoptosis associated with intraocular inflammation...
  9. pmc Expression of erythropoietin receptor in human epiretinal membrane of proliferative diabetic retinopathy
    Satoru Kase
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, N15 W7, Kita ku, Sapporo 060 8638 Japan
    Br J Ophthalmol 91:1376-8. 2007
    ..The aim of this study was to examine the expression of Epo and the Epo receptor (EpoR) in epiretinal membranes with and without diabetes...
  10. ncbi request reprint Immunolocalization of cyclin D1 in the developing lens of c-maf -/- mice
    Satoru Kase
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, N15 W7, Kita ku, Sapporo 060 8638, Japan
    Acta Histochem 107:469-72. 2006
    ..Many cyclin D1-positive nuclei were observed in lens epithelial cells as well as posterior lens cells. These results are consistent with c-maf playing a role in the regulation of cyclin D1 in developing lens cells...
  11. ncbi request reprint Expression of thymidine phosphorylase in choroidal malignant melanoma associated with neovascular glaucoma
    Satoru Kase
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Pathol Int 55:569-73. 2005
    ..Another case of choroidal melanoma without NVG had less marked immunoreactivity. These results suggest that the production of dThdPase by melanoma cells correlates with the pathogenesis of NVG...
  12. ncbi request reprint Increased osteopontin levels in the vitreous of patients with diabetic retinopathy
    Satoru Kase
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Ophthalmic Res 39:143-7. 2007
    ..The aim of this study is to analyze the OPN levels in vitreous fluid obtained from diabetic retinopathy (DR) and non-DR patients...
  13. pmc Expression of glutamine synthetase and cell proliferation in human idiopathic epiretinal membrane
    S Kase
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo 060 8638, Japan
    Br J Ophthalmol 90:96-8. 2006
    ..The aim of this study was to examine the expression of cell cycle related molecules and glutamine synthetase (GS), which is expressed in Müller cells and their processes, in ERM tissues...
  14. ncbi request reprint Expression of erythropoietin receptor in human Merkel cell carcinoma of the eyelid
    Satoru Kase
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, N15 W7, Kita ku, Sapporo, 060 8638 Japan
    Anticancer Res 26:4535-7. 2006
    ..The expression of erythropoietin (Epo) and Epo receptor (EpoR), as well as vascular endothelial growth factor (VEGF), VEGF receptor (VEGFR) and basic fibroblast growth factor (bFGF) were examined in human MCC tissues...
  15. ncbi request reprint Expression of telomerase (hTERT) in aldosterone-producing adrenocortical tumors
    Daniele Sticchi
    Department of Clinical and Experimental Medicine, University of Padua, Italy
    Int J Mol Med 17:469-74. 2006
    ..In conclusion, RT-PCR measurement of hTERT mRNA is a hallmark of malignant adrenocortical tumors, but identifies also a subset of hTERT-expressing APAs that might show metastatic spread at long-term follow-up...
  16. pmc Expression of p27(KIP1) and cyclin D1, and cell proliferation in human pterygium
    Satoru Kase
    Department of Ophthalmology, Sapporo Social Insurance General Hospital, Sapporo, Japan
    Br J Ophthalmol 91:958-61. 2007
    ..The pterygium is a growth onto the cornea of fibrovascular tissue that is continuous with the conjunctiva, whereas the mechanisms of cell proliferation in pterygium epithelium are unknown...
  17. ncbi request reprint Phosphorylation of p27(KIP1) in the mitotic cells of the corneal epithelium
    Satoru Kase
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Curr Eye Res 31:307-12. 2006
    ..The aim of this study is to examine the expression of p27(KIP1) and its phosphorylation in corneal epithelium...
  18. ncbi request reprint Cyclo-oxygenase-2 expression in human idiopathic epiretinal membrane
    Satoru Kase
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan
    Retina 30:719-23. 2010
    ..The purpose of this study was to examine the expression of cyclo-oxygenase (COX)-2 in the idiopathic epiretinal membrane (IERM), inner limiting membrane (ILM), and proliferative diabetic retinopathy membrane...
  19. doi request reprint Increased expression of αA-crystallin in human diabetic eye
    Satoru Kase
    Doheny Eye Institute, Los Angeles, CA, USA
    Int J Mol Med 28:505-11. 2011
    ..Thus, αA-crystallin and AGE were highly expressed in human diabetic retina. αA-crystallin responded to AGE accumulation, which may contribute to the protection of photoreceptors against AGE-related retinal tissue injury...
  20. ncbi request reprint Increased expression of erythropoietin receptor in human pterygial tissues
    Satoru Kase
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Int J Mol Med 20:699-702. 2007
    ..These results suggest that the Epo-independent EpoR-signaling pathway plays a potential role in cell proliferation and angiogenesis in human pterygium...
  21. ncbi request reprint [Role of p27 (KIP 1) in regulation of retinal cell proliferation]
    Satoru Kase
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Nihon Ganka Gakkai Zasshi 111:577-86. 2007
    ..We conclude that the clarification of the mechanisms of p27 (KIP 1) expression might contribute to the discovery of a novel therapy targeting for human retinal diseases...
  22. ncbi request reprint Phosphorylation of p27(KIP1) in lens epithelial cells after extraction of fiber cells
    Satoru Kase
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Int J Mol Med 18:1187-91. 2006
    ..It is possible that the phosphorylation of p27(KIP1), and cyclin D1 expression are regulated by the ERK pathway in lens cells after the extraction of fiber cells...
  23. ncbi request reprint Expression of cdc2 and p27(KIP1) phosphorylation in mitotic cells of the human retinoblastoma
    Satoru Kase
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Int J Mol Med 17:465-8. 2006
    ..Double staining demonstrated the same localization of T187-phospho-p27 and cdc2 in mitotic cells. These results suggest that p27(KIP1) interacts with cdc2 in the M-phase of human retinoblastoma cells...
  24. ncbi request reprint Elevation of serum Krebs von den Lunge-6 levels in patients with tubulointerstitial nephritis and uveitis syndrome
    Satoru Kase
    Department of Ophthalmology and Visual Sciences and Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Am J Kidney Dis 48:935-41. 2006
    ..The aim of the present study is to quantify serum KL-6 levels in patients with TINU syndrome, which has no pulmonary and sarcoid lesions, and elucidate the usefulness of KL-6 for the diagnosis and follow-up of this syndrome...
  25. ncbi request reprint Proliferative diabetic retinopathy with lymphocyte-rich epiretinal membrane associated with poor visual prognosis
    Satoru Kase
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Invest Ophthalmol Vis Sci 50:5909-12. 2009
    ..The aim of this study was to analyze lymphocyte infiltration using immunohistochemistry in proliferative diabetic retinopathy (PDR) membranes...
  26. pmc Immunolocalisation of E-cadherin and beta-catenin in human pterygium
    Satoru Kase
    Department of Ophthalmology, Sapporo Social Insurance General Hospital, Sapporo, Japan
    Br J Ophthalmol 91:1209-12. 2007
    ..The mechanisms of cell proliferation and adhesion in pterygium epithelium, however, are unknown. The aim of this study was to analyse the expression of cell adhesion molecules in pterygium tissues...
  27. ncbi request reprint Anti-inflammatory effects of aronia extract on rat endotoxin-induced uveitis
    Kazuhiro Ohgami
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Invest Ophthalmol Vis Sci 46:275-81. 2005
    ..7) treated with ACE in vitro, to clarify the anti-inflammatory effect...
  28. ncbi request reprint Disappearance of p27(KIP1) and increase in proliferation of the lens cells after extraction of most of the fiber cells of the lens
    Satoru Kase
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Curr Eye Res 30:437-42. 2005
    ..The purpose of this study was to examine the correlation between the expression of p27(KIP1) and cell proliferation in the lens cells after the extraction of lens fiber cells...
  29. ncbi request reprint Phosphorylation of extracellular signal-regulated kinase and p27(KIP1) after retinal detachment
    Satoru Kase
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, N15 W7, Kita ku, Sapporo, 060 8638, Japan
    Graefes Arch Clin Exp Ophthalmol 244:352-8. 2006
    ..The roles of the extracellular signal-regulated kinase (ERK) pathway in the expression of cyclin D1 and p27(KIP1), the phosphorylation of p27(KIP1), and proliferation activity were examined after retinal detachment...
  30. ncbi request reprint Phosphorylation of p27(KIP1) in the developing retina and retinoblastoma
    Satoru Kase
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, N15 W7, Kita ku, Sapporo 060 8638, Japan
    Int J Mol Med 16:257-62. 2005
    ..PCNA was expressed in rosette-forming cells. In conclusion, T187-phospho-p27(KIP1) was correlated with M phase of the cell cycle in the developing retina and retinoblastoma...
  31. ncbi request reprint Suppressive effects of astaxanthin against rat endotoxin-induced uveitis by inhibiting the NF-kappaB signaling pathway
    Yukari Suzuki
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, N15 W7, Sapporo 060 8638, Japan
    Exp Eye Res 82:275-81. 2006
    ..These results suggest that AST reduces ocular inflammation in eyes with EIU by downregulating proinflammatory factors and by inhibiting the NF-kappaB-dependent signaling pathway...
  32. ncbi request reprint Involvement of p27KIP1 in the proliferation of the developing corneal endothelium
    Kazuhiko Yoshida
    Department of Ophthalmology, Hokkaido University School of Medicine, Sapporo, Japan
    Invest Ophthalmol Vis Sci 45:2163-7. 2004
    ..To examine the involvement of p27(KIP1) in the regulation of the proliferation of the developing corneal endothelium...
  33. ncbi request reprint Effects of fucoxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo
    Kenji Shiratori
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, N15 W7, Kita ku, Sapporo 060 8638, Japan
    Exp Eye Res 81:422-8. 2005
    ..The present result indicate fucoxanthin suppresses the inflammation of EIU by blocking the iNOS and COX-2 protein expression and its anti-inflammatory effect on eye is comparable with the effect of predinisolone used in similar doses...
  34. ncbi request reprint Distribution of p27(KIP1), cyclin D1, and proliferating cell nuclear antigen after retinal detachment
    Kazuhiko Yoshida
    Department of Ophthalmology, Hokkaido University School of Medicine, N15 W7, Kita ku, 060 8638 Sapporo, Japan
    Graefes Arch Clin Exp Ophthalmol 242:437-41. 2004
    ..To examine the expression of the p27(KIP1), cyclin D1, and proliferating cell nuclear antigen (PCNA) in the retina and retinal pigment epithelium (RPE) after retinal detachment...
  35. ncbi request reprint Captopril suppresses inflammation in endotoxin-induced uveitis in rats
    Iliyana Ilieva
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, N15 W7 Kita ku, Sapporo 060 8638, Japan
    Exp Eye Res 83:651-7. 2006
    ..The present results indicate that captopril suppresses the inflammation in EIU by inhibiting the NF-kappaB-dependent pathway and the subsequent production of pro-inflammatory mediators...
  36. pmc alphaB-crystallin regulation of angiogenesis by modulation of VEGF
    Satoru Kase
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Blood 115:3398-406. 2010
    ..Our studies indicate an important role for alphaB-crystallin as a chaperone for VEGF-A in angiogenesis and its potential as a therapeutic target...
  37. doi request reprint Soluble vascular adhesion protein-1 accumulates in proliferative diabetic retinopathy
    Miyuki Murata
    Laboratory of Ocular Cell Biology and Visual Science, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Invest Ophthalmol Vis Sci 53:4055-62. 2012
    ..This study explores a link between increased level of sVAP-1 and oxidative stress in proliferative diabetic retinopathy (PDR) with a focus on mechanistic components to form sVAP-1 by shedding from retinal endothelial cells...
  38. ncbi request reprint The effects of naringin and naringenin on endotoxin-induced uveitis in rats
    Kenji Shiratori
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    J Ocul Pharmacol Ther 21:298-304. 2005
    ..The possible mechanism for the antiocular inflammatory effect may be the suppression of PGE2 and NO by naringin and naringenin...
  39. doi request reprint Alphab-crystallin expression in epiretinal membrane of human proliferative diabetic retinopathy
    Zhenyu Dong
    Laboratory of Ocular Cell Biology and Visual Science, Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan
    Retina 32:1190-6. 2012
    ..To examine the expression of alphaB-crystallin and its colocalization with vascular endothelial growth factor in the epiretinal membrane of human proliferative diabetic retinopathy...
  40. ncbi request reprint Involvement of p27(KIP1) in proliferation of the retinal pigment epithelium and ciliary body
    Kazuhiko Yoshida
    Department of Ophthalmology, Hokkaido University School of Medicine, N15 W7, Kita ku, 060 8638 Sapporo, Japan
    Anat Embryol (Berl) 208:145-50. 2004
    ..These results suggest that p27(KIP1) was involved in regulation of proliferation in the RPE and the ciliary body...
  41. ncbi request reprint Expression of maf-B mRNA in the epithelium around the eyelid closure of the mouse eye at embryonic day 18
    Satoru Kase
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, N15 W7, Kita ku, 060 8638, Sapporo, Japan
    Anat Embryol (Berl) 209:153-6. 2004
    ..In contrast, basal cells in the eyelid closure and in the epidermis, as well as keratinizing cells, did not express maf-B. These data indicate that maf-B mRNA is expressed during development of the eyelid closure...
  42. ncbi request reprint Expression of vascular endothelial growth factor in human ocular adnexal lymphoma
    Satoshi Kinoshita
    Laboratory of Ocular Cell Biology and Visual Science, Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan
    Invest Ophthalmol Vis Sci 55:3461-7. 2014
    ..To examine the expression of VEGF in extranodal marginal zone B-cell lymphoma (EMZL) and reactive lymphoid hyperplasia (RLH) of human ocular adnexa, and analyze the correlation with the intratumoral microvessel density (MVD)...
  43. doi request reprint Clinical features of human T lymphotropic virus type 1-associated uveitis in Hokkaido, Japan
    Satoru Kase
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Jpn J Ophthalmol 57:379-84. 2013
    ..To clarify the clinical features of human lymphotropic virus type 1 (HTLV-1)-associated uveitis (HAU) in patients of Hokkaido University Hospital, Hokkaido, northern Japan...
  44. doi request reprint Expression of vascular endothelial growth factor and intravitreal anti-VEGF therapy with bevacizumab in vasoproliferative retinal tumors
    Wataru Saito
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Retina 33:1959-67. 2013
    ..To examine whether vasoproliferative retinal tumors (VPRTs) express vascular endothelial growth factor and respond to intravitreal bevacizumab injection...
  45. doi request reprint Immunolocalization of vascular adhesion protein-1 in human conjunctival tumors
    Junichi Fukuhara
    Laboratory of Ocular Cell Biology and Visual Science, Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Ophthalmic Res 48:33-7. 2012
    ..We analyzed the expression and immunolocalization of vascular adhesion protein (VAP)-1 in conjunctival tumors and normal conjunctival tissue of humans...
  46. pmc Inhibition of nuclear factor-kappa B activation attenuates hydrogen peroxide-induced cytotoxicity in human lens epithelial cells
    Xue Hai Jin
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    Br J Ophthalmol 91:369-71. 2007
    ..The authors investigated the relationship between H(2)O(2)-induced cytotoxicity and activation of nuclear factor kappa B (NF-kappaB) in human lens epithelial (HLE) cells...
  47. ncbi request reprint Macrophage migration inhibitory factor ameliorates UV-induced photokeratitis in mice
    Nobuyoshi Kitaichi
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Exp Eye Res 86:929-35. 2008
    ..In conclusion, UV-damaged cornea is recoverable without MIF, however it takes longer time than normal condition. Cornea is less damaged and can make a quick recovery when ocular tissue is enough supplied with MIF...
  48. pmc Expression of alpha-crystallin in retinoblastoma
    Satoru Kase
    Doheny Eye Institute, Doheny Vision Research Center 211, Los Angeles CA 90033, USA
    Arch Ophthalmol 127:187-92. 2009
    ..To examine the expression of alpha-crystallin, a small heat-shock protein family, and apoptosis in retinal neoplastic cells...
  49. ncbi request reprint Slowly progressive cancer-associated retinopathy
    Wataru Saito
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Nishi 7 chome, Kita 15 jou, Kita ku, Sapporo 060 8638, Japan
    Arch Ophthalmol 125:1431-3. 2007
  50. ncbi request reprint Expression of p27(KIP1) and cell proliferation in human retina and retinoblastoma
    Satoru Kase
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, N15 W7, Kita ku, Sapporo 060 8638, Japan
    Anticancer Res 25:3843-6. 2005
    ..The aim of this study was to examine the correlation between the expression of p27(KIP1) and cell proliferation in human retina and retinoblastoma...
  51. pmc Regulated secretion of complement factor H by RPE and its role in RPE migration
    Yeong Hoon Kim
    Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
    Graefes Arch Clin Exp Ophthalmol 247:651-9. 2009
    ..Little is known, however, about the factors regulating local expression and secretion of CFH by retinal pigment epithelial cells (RPE)...
  52. pmc Attainment of polarity promotes growth factor secretion by retinal pigment epithelial cells: relevance to age-related macular degeneration
    Shozo Sonoda
    Department of Ophthalmology, Keck School of Medicine of University of Southern California, Los Angeles, CA 90089, USA
    Aging (Albany NY) 2:28-42. 2010
    ....
  53. doi request reprint Microphthalmia and lack of vitreous body in transgenic mice expressing the first immunoglobulin-like domain of nectin-1
    Kazuhiko Yoshida
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo 060 8638, Japan
    Graefes Arch Clin Exp Ophthalmol 246:543-9. 2008
    ..The purpose of this study is to examine functions of the extracellular domains of nectin-1 in eye development using transgenic technology...
  54. doi request reprint Intraocular neovascularization associated with choroidal ganglioneuroma in neurofibromatosis type 1
    Kan Ishijima
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Hokkaido, Japan
    Eur J Ophthalmol 21:837-40. 2011
    ..The authors report a case of NF-1 presenting with globe enlargement and subretinal and choroidal neovascularization associated with choroidal ganglioneuroma...
  55. ncbi request reprint Intravitreal anti-vascular endothelial growth factor therapy with bevacizumab for tuberous sclerosis with macular oedema
    Wataru Saito
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Acta Ophthalmol 88:377-80. 2010
    ..To describe two patients with macular oedema secondary to tuberous sclerosis complex (TSC) who were treated with intravitreal bevacizumab injection...
  56. ncbi request reprint The effects of Ginkgo biloba extract on lipopolysaccharide-induced inflammation in vitro and in vivo
    Iliyana Ilieva
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    Exp Eye Res 79:181-7. 2004
    ..7) treated with GBE in vitro to clarify the anti-inflammatory effect...
  57. ncbi request reprint Bilateral diffuse uveal melanocytic proliferation in a patient with cancer-associated retinopathy
    Wataru Saito
    Department of Ophthalmology and Visual Sciences, Hokkaido Graduate School of Medicine, Sapporo, Japan
    Am J Ophthalmol 140:942-5. 2005
    ..To describe a patient with bilateral diffuse uveal melanocytic proliferation (BDUMP) and cancer-associated retinopathy (CAR)...
  58. doi request reprint Expression of vascular endothelial growth factor C in human pterygium
    Junichi Fukuhara
    Laboratory of Ocular Cell Biology and Visual Science, Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Nishi 7, Kita 15, Sapporo 060 8638, Japan
    Histochem Cell Biol 139:381-9. 2013
    ..The present findings suggest the potential role of VEGF-C in the pathogenesis and development of a pterygium through lymphangiogenesis and the VEGF-C/VEGFR-3 pathway as a novel therapeutic target for the human pterygium...
  59. ncbi request reprint Usefulness of quantifying serum KL-6 levels in the follow-up of uveitic patients with sarcoidosis
    Nobuyoshi Kitaichi
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Graefes Arch Clin Exp Ophthalmol 244:433-7. 2006
    ..The purpose of the present study was to investigate the clinical usefulness of quantifying serum KL-6 levels for following-up the patients with sarcoidosis...
  60. pmc TNF-α decreases VEGF secretion in highly polarized RPE cells but increases it in non-polarized RPE cells related to crosstalk between JNK and NF-κB pathways
    Hiroto Terasaki
    Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    PLoS ONE 8:e69994. 2013
    ..TNF-α-induced VEGF up-regulation may cause neovascularization by non-polarized or non-physiological RPE cells. ..
  61. pmc Conjunctival lymphoma arising from reactive lymphoid hyperplasia
    Junichi Fukuhara
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Nishi 7, Kita 15, Kita ku, Sapporo 060 8638, Japan
    World J Surg Oncol 10:194. 2012
    ....
  62. doi request reprint Correlation between elevation of serum antinuclear antibody titer and decreased therapeutic efficacy in the treatment of Behçet's disease with infliximab
    Daiju Iwata
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo, Japan
    Graefes Arch Clin Exp Ophthalmol 250:1081-7. 2012
    ..In the present study, we investigated the correlation between this reduced therapeutic effect and elevation of the serum antinuclear antibody (ANA) titers in patients with BD who were undergoing infliximab therapy...
  63. pmc Transforming growth factor beta in retinoblastoma-related cataract
    Satoru Kase
    Doheny Eye Institute, Los Angeles, CA 90033, USA
    Arch Ophthalmol 126:1539-42. 2008
    ..To analyze the histopathology and expression of transforming growth factor beta (TGF-beta) in retinoblastoma with and without cataractous changes...
  64. ncbi request reprint Peripapillary subretinal neovascularization in retinoblastoma
    Satoru Kase
    Doheny Eye Institute, 1450 San Pablo St, DRVC 211, Los Angeles, CA 90033, USA
    Graefes Arch Clin Exp Ophthalmol 246:931-4. 2008
    ..Peripapillary subretinal neovascularization (PSRNV) is a rare type of choroidal neovascularization. Herein we report a case of retinoblastoma complicating PSRNV, and discuss the histopathological findings...
  65. ncbi request reprint [Proliferative regulation in the cornea and lens]
    Kazuhiko Yoshida
    Department of Ophthalmology, Hokkaido University School of Medicine, N 15, W 7, Kita ku, Sapporo 060 8638, Japan
    Nihon Ganka Gakkai Zasshi 107:678-86. 2003
    ..To examine the mechanism of regulation of proliferation in epithelial scraped cornea and the developing lens...
  66. pmc Induction of heat shock protein 70 ameliorates ultraviolet-induced photokeratitis in mice
    Anton Lennikov
    Laboratory of Ocular Cell Biology and Visual Science, Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Int J Mol Sci 14:2175-89. 2013
    ..GGA-treatment induced HSP70 expression and ameliorated UV-induced corneal damage through the reduced NF-κB activation and possibly increased Akt phosphorilation...
  67. ncbi request reprint Repeated exacerbations of ocular inflammation with vitreous hemorrhage in a patient with HLA-B27 associated uveitis
    Satoru Kase
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Med Invest 54:350-3. 2007
    ..Through the decreased vitreous hemorrhage, Weiss ring was detected later. The vitreous hemorrhage found in this patient is a severe exacerbation, and might be a consequence of the vitritis that leads to posterior vitreous detachment...
  68. ncbi request reprint [Two cases of conjunctival malignant melanoma treated with topical interferon alpha-2b drop as an adjuvant therapy]
    Satoru Kase
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Nihon Ganka Gakkai Zasshi 115:1043-7. 2011
    ..Conjunctival malignant melanoma, a rare malignant tumor in Japan, develops local recurrence and lymph node metastasis. We herein report two cases with conjunctival melanoma treated with topical IFNalpha-2b eye drops...
  69. pmc Expression of alpha-crystallins in human sebaceous carcinoma of the eyelid
    Panayota K Rigas
    Doheny Eye Institute, Los Angeles, California 90033, USA
    Eur J Ophthalmol 19:702-7. 2009
    ..Crystallins are molecular chaperones that protect various cells from apoptosis. This study used immunohistochemistry to examine the expression of alphaA-crystallin and alphaB-crystallin in human sebaceous carcinoma tissues...
  70. ncbi request reprint Tyrosinase gene family and Vogt-Koyanagi-Harada disease in Japanese patients
    Yukihiro Horie
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Mol Vis 12:1601-5. 2006
    ..The aim of the present study was to examine the genetic background of Vogt-Koyanagi-Harada (VKH) disease in a Japanese population by analyzing the tyrosinase gene family (TYR, TYRP1, and dopachrome tautomerase (DCT))...
  71. doi request reprint Salivary duct carcinoma metastatic to eyelid and orbit-a case report
    Jignesh G Parikh
    Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
    Graefes Arch Clin Exp Ophthalmol 246:1185-8. 2008
    ..We describe a case of parotid gland salivary duct carcinoma metastatic to the eyelid and orbit, as confirmed by immunohistochemical analysis. To the best of our knowledge, this is the first such case reported in the literature...
  72. pmc Diffuse infiltrating retinoblastoma invading subarachnoid space
    Satoru Kase
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo
    Clin Ophthalmol 5:861-3. 2011
    ..The patient died due to brain involvement 27 months after enucleation. Ophthalmologists should be aware that diffuse infiltrating retinoblastoma may show an unfavorable course if its diagnosis is delayed...
  73. ncbi request reprint [Correlation with histological findings and visual prognosis in epiretinal membrane of human diabetic retinopathy]
    Satoru Kase
    Department of Ophthalmology Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Nihon Ganka Gakkai Zasshi 115:998-1006. 2011
    ....
  74. ncbi request reprint [Pyogenic granuloma developing rapidly after excision of corneal/conjunctival intraepithelial neoplasia]
    Kan Ishijima
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Nihon Ganka Gakkai Zasshi 114:1036-9. 2010
    ..We herein report the usefulness of brushing cytology for diagnosis of pyogenic granuloma, which rapidly developed after surgical resection of corneal/conjunctial intraepithelial neoplasia (CIN)...
  75. ncbi request reprint COX-2 correlates with F-box protein, Skp2 expression and prognosis in human gastric carcinoma
    Soichiro Honjo
    Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine, Tottori University, Tottori 683 8503, Japan
    Int J Oncol 26:353-60. 2005
    ....
  76. ncbi request reprint Expression of cyclo-oxygenase-2 is correlated with high intratumoral microvessel density and low apoptotic index in human esophageal squamous cell carcinomas
    Satoru Kase
    First Department of Pathology, Faculty of Medicine, Tottori University, 86, Nishi cho, Yonago, Tottori 683 8503, Japan
    Virchows Arch 442:129-35. 2003
    ..Thus COX-2 might play an important role in the angiogenesis and regulation of apoptosis in esophageal squamous cell carcinomas...
  77. ncbi request reprint Expression of Fas and Fas ligand in esophageal tissue mucosa and carcinomas
    Satoru Kase
    First Department of Pathology, Faculty of Medicine, Tottori University, Tottori 683 8503, Japan
    Int J Oncol 20:291-7. 2002
    ..On the other hand, Fas-expressing carcinoma cells were associated with frequent apoptosis. Both FasL and Fas expressions correlate with prognostic significance in esophageal SCCs...
  78. ncbi request reprint Expression of cyclooxygenase-1 and cyclooxygenase-2 in human esophageal mucosa, dysplasia and carcinoma
    Satoru Kase
    Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine, Tottori University, Yonago, Japan
    Pathobiology 71:84-92. 2004
    ..Two isoforms of COX have been identified: COX-1 and COX-2. We examined the expression of COX-1 and COX-2 in esophageal normal mucosa, dysplasia and squamous cell carcinoma (SCC)...
  79. ncbi request reprint Tubular adenoma and intramucosal intestinal-type adenocarcinoma of the stomach: what are the pathobiological differences?
    Satoru Kase
    Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine, Tottori University, 86 NIshi cho, Yonago, Tottori 683 8503, Japan
    Gastric Cancer 6:71-9. 2003
    ..The aim of the present study was to clarify the clinicopathological significance of gastric intramucosal tumors from the pathobiological viewpoint...
  80. ncbi request reprint Inhibition of the PI3K-Akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line, MKN-45
    Mitsuhiko Osaki
    Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine, Tottori University, 86 NIshi cho, Yonago, 683 8503 Tottori, Japan
    J Cancer Res Clin Oncol 130:8-14. 2004
    ..We concluded that: 1) the PI3K-Akt pathway plays an important role in preventing Fas-mediated apoptosis; and 2) a PI3 K inhibitor, such as LY294002, might be a useful anti-tumoral agent for gastric carcinoma...
  81. ncbi request reprint Anti-Fas antibody-induced apoptosis and its signal transduction in human gastric carcinoma cell lines
    Keiko Adachi
    Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine, Tottori University, 86 NIshi cho, Yonago, Tottori 683 8503, Japan
    Int J Oncol 23:713-9. 2003
    ..These findings suggest that anti-Fas antibody induced apoptosis through the type II signaling pathway in the human gastric carcinoma cell lines, MKN-45 and KATO-III...
  82. ncbi request reprint Comment on the recent publication "Conjunctival nodules associated with Vogt-Koyanagi-Harada disease"
    Satoru Kase
    Graefes Arch Clin Exp Ophthalmol 246:323; author reply 325-6. 2008
  83. ncbi request reprint Chronic panuveitis and scleritis in a patient with cryptogenic organizing pneumonia
    Wataru Saito
    Jpn J Ophthalmol 50:558-61. 2006
  84. ncbi request reprint Epstein-Barr virus-infected malignant T/NK-cell lymphoma in a patient with hypersensitivity to mosquito bites
    Satoru Kase
    Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine, Tottori University, Yonago, Japan
    Int J Surg Pathol 12:265-72. 2004
    ....
  85. ncbi request reprint Cyclooxygenase-2 expression in human gastric tubular adenomas and carcinomas; correlation with intratumoral microvessel density and apoptotic index
    Soichiro Honjo
    Division of Organ Pathology, Department of Microbiology and Pathology and Faculty of Medicine, Tottori University, Yonago, Tottori, 683 8503, Japan
    Anticancer Res 24:1439-44. 2004
    ..Cyclooxygenase (COX)-2 plays an important role in carcinogenesis in various human malignancies. This study examined the relationship among COX-2 expression, angiogenesis and apoptosis in human gastric adenoma and carcinoma...