Takeshi Inoue

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. ncbi request reprint [Treatment strategy of refractory depression and its presynaptic mechanism of action]
    Takeshi Inoue
    Department of Psychiatry, Neural Function, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 23:11-20. 2003
  2. doi request reprint Sertraline treatment of patients with major depressive disorder who failed initial treatment with paroxetine or fluvoxamine
    Takeshi Inoue
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo 060 8638, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 38:223-7. 2012
  3. pmc Utility and limitations of PHQ-9 in a clinic specializing in psychiatric care
    Takeshi Inoue
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    BMC Psychiatry 12:73. 2012
  4. ncbi request reprint Long-term outcome of antidepressant-refractory depression: the relevance of unrecognized bipolarity
    Takeshi Inoue
    Department of Psychiatry, Neural Function Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    J Affect Disord 95:61-7. 2006
  5. ncbi request reprint Effect of combined treatment with noradrenaline and serotonin reuptake inhibitors on conditioned freezing
    Takeshi Inoue
    Department of Psychiatry, Neural Function, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo 060 8638, Japan
    Eur J Pharmacol 540:91-5. 2006
  6. doi request reprint Long-term naturalistic follow-up of lithium augmentation: relevance to bipolarity
    Takeshi Inoue
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    J Affect Disord 129:64-7. 2011
  7. doi request reprint Pramipexole for stage 2 treatment-resistant major depression: an open study
    Takeshi Inoue
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:1446-9. 2010
  8. ncbi request reprint Selective serotonin reuptake inhibitor reduces conditioned fear through its effect in the amygdala
    Takeshi Inoue
    Department of Psychiatry, Neural Function, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    Eur J Pharmacol 497:311-6. 2004
  9. doi request reprint Depression and major depressive disorder in patients with Parkinson's disease
    Takeshi Inoue
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo 060 8638, Japan
    Mov Disord 25:44-9. 2010
  10. ncbi request reprint [The front line of the treatment of anxiety disorders]
    Takeshi Inoue
    Nihon Yakurigaku Zasshi 125:297-300. 2005

Collaborators

Detail Information

Publications94

  1. ncbi request reprint [Treatment strategy of refractory depression and its presynaptic mechanism of action]
    Takeshi Inoue
    Department of Psychiatry, Neural Function, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 23:11-20. 2003
    ..Subchronic lithium further increases SSRI-induced increases in extracellular serotonin concentrations, and this effect is suggested to be the mechanism of action for lithium augmentation of antidepressants...
  2. doi request reprint Sertraline treatment of patients with major depressive disorder who failed initial treatment with paroxetine or fluvoxamine
    Takeshi Inoue
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo 060 8638, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 38:223-7. 2012
    ..These preliminary data suggest that the switching strategy from paroxetine or fluvoxamine to sertraline might be effective and well-tolerated in patients with non-remitted or treatment-intolerant major depressive disorder...
  3. pmc Utility and limitations of PHQ-9 in a clinic specializing in psychiatric care
    Takeshi Inoue
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    BMC Psychiatry 12:73. 2012
    ..This study assesses the accuracy of PHQ-9 in screening for major depressive episode and in diagnosing major depressive episode in patients of a psychiatric specialty clinic...
  4. ncbi request reprint Long-term outcome of antidepressant-refractory depression: the relevance of unrecognized bipolarity
    Takeshi Inoue
    Department of Psychiatry, Neural Function Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    J Affect Disord 95:61-7. 2006
    ..Therefore, the present study investigated the long-term outcome of 26 antidepressant-refractory patients with depression, whom we had studied and treated in 1995...
  5. ncbi request reprint Effect of combined treatment with noradrenaline and serotonin reuptake inhibitors on conditioned freezing
    Takeshi Inoue
    Department of Psychiatry, Neural Function, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo 060 8638, Japan
    Eur J Pharmacol 540:91-5. 2006
    ..These results suggest that adding noradrenaline reuptake inhibitors to serotonin reuptake inhibitors adversely affects fear, at least with acute treatment...
  6. doi request reprint Long-term naturalistic follow-up of lithium augmentation: relevance to bipolarity
    Takeshi Inoue
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    J Affect Disord 129:64-7. 2011
    ....
  7. doi request reprint Pramipexole for stage 2 treatment-resistant major depression: an open study
    Takeshi Inoue
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:1446-9. 2010
    ..To examine the effectiveness and safety of adjunctive pramipexole in the treatment of stage 2 treatment-resistant major depressive disorder...
  8. ncbi request reprint Selective serotonin reuptake inhibitor reduces conditioned fear through its effect in the amygdala
    Takeshi Inoue
    Department of Psychiatry, Neural Function, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    Eur J Pharmacol 497:311-6. 2004
    ....
  9. doi request reprint Depression and major depressive disorder in patients with Parkinson's disease
    Takeshi Inoue
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo 060 8638, Japan
    Mov Disord 25:44-9. 2010
    ..The low-prevalence rate of MDD in our patient population suggests that PD may be a psychological stressor for MDD, but does not necessarily induce MDD...
  10. ncbi request reprint [The front line of the treatment of anxiety disorders]
    Takeshi Inoue
    Nihon Yakurigaku Zasshi 125:297-300. 2005
  11. doi request reprint SSRIs and conditioned fear
    Takeshi Inoue
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:1810-9. 2011
    ..Furthermore, these behavioral data provide a new explanation of neurochemical adaptations to contextual conditioned fear: increased 5-HT transmission seems to decrease, not increase, fear...
  12. ncbi request reprint [The role of serotonin in conditioned fear]
    Takeshi Inoue
    Nihon Yakurigaku Zasshi 125:385-8. 2005
  13. ncbi request reprint Effect of a dopamine D1/5 receptor antagonist on haloperidol-induced inhibition of the acquisition of conditioned fear
    Takeshi Inoue
    Department of Psychiatry, Neural Function, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    Eur J Pharmacol 519:253-8. 2005
    ..These results suggest that combined dopamine D2-like receptor antagonism and dopamine D1-like receptor antagonism is a promising and effective strategy to increase antipsychotic effects...
  14. doi request reprint Effect of co-administration of a serotonin-noradrenaline reuptake inhibitor and a dopamine agonist on extracellular monoamine concentrations in rats
    Yuji Kitaichi
    Department of Psychiatry, Neural Function, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    Eur J Pharmacol 584:285-90. 2008
    ....
  15. ncbi request reprint Glucose and lipid metabolism of long-term risperidone monotherapy in patients with schizophrenia
    Mari Murashita
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Psychiatry Clin Neurosci 61:54-8. 2007
    ..A high level of plasma ghrelin might increase appetite, leading to exacerbation of metabolic impairment...
  16. ncbi request reprint Effects of cytochrome P450 (CYP) 3A4 inhibitors on the anxiolytic action of tandospirone in rat contextual conditioned fear
    Hiroyuki Nishikawa
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:926-31. 2007
    ..This suggests the CYP3A4 isoform is involved in the metabolism of tandospirone, in vivo. Therefore, drugs with CYP3A4 inhibitory property may facilitate the anxiolytic effect of tandospirone when treating human anxiety disorders...
  17. ncbi request reprint Effect of co-administration of subchronic lithium pretreatment and acute MAO inhibitors on extracellular monoamine levels and the expression of contextual conditioned fear in rats
    Yuji Kitaichi
    Department of Psychiatry, Neural Function, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo 060 8638, Japan
    Eur J Pharmacol 532:236-45. 2006
    ....
  18. doi request reprint Effects of mood stabilizers on adult dentate gyrus-derived neural precursor cells
    Shuken Boku
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:111-7. 2011
    ..However, valproate and lamotrigine increased the ratio of astrocytes and decreased that of neurons. Therefore, these four stabilizers exhibited both common and differential effects on ADP proliferation, apoptosis, and differentiation...
  19. doi request reprint Pharmacokinetic interaction between tandospirone and fluvoxamine in the rat contextual conditioned fear stress model and its functional consequence: Involvement of cytochrome P450 3A4
    Hiroyuki Nishikawa
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Psychiatry Clin Neurosci 62:591-6. 2008
    ..The purpose of the present study was to clarify the pharmacokinetic interaction between tandospirone and fluvoxamine and to evaluate their combined effect in the rat anxiety model...
  20. doi request reprint Mood stabilizers commonly restore staurosporine-induced increase of p53 expression and following decrease of Bcl-2 expression in SH-SY5Y cells
    Ning Song
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 38:183-9. 2012
    ..In addition, p53 overexpression decreased the expression of Bcl-2. Taken together, these results suggest that p53 and Bcl-2 may be involved in a part of mood-stabilizing effects...
  21. ncbi request reprint Effects of co-administration of a selective serotonin reuptake inhibitor and monoamine oxidase inhibitors on 5-HT-related behavior in rats
    Takeshi Izumi
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo 060 8638, Japan
    Eur J Pharmacol 532:258-64. 2006
    ..These data suggest that non-selective MAO and selective MAO-A inhibitors can induce 5-HT syndrome in humans when co-administered with SSRI. Further, the risk of 5-HT syndrome may be lower with the selective MAO-B inhibitor, selegiline...
  22. ncbi request reprint Effect of co-administration of lithium and reboxetine on extracellular monoamine concentrations in rats
    Yuji Kitaichi
    Department of Psychiatry, Neural Function, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita, Sapporo 060 8638, Japan
    Eur J Pharmacol 489:187-91. 2004
    ..Thus, combined lithium and reboxetine produces an additive effect neurochemically rather than their interaction...
  23. doi request reprint Lamotrigine blocks apoptosis induced by repeated administration of high-dose methamphetamine in the medial prefrontal cortex of rats
    Yasuya Nakato
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo, Hokkaido, Japan
    Neurosci Lett 490:161-4. 2011
    ..5 mg/kg) in the mPFC. The LTG blocks histological abnormalities induced by repeated administration of METH, which suggests a mechanism of LTG that protects against progressive pathophysiology in schizophrenia...
  24. ncbi request reprint Effect of milnacipran on extracellular monoamine concentrations in the medial prefrontal cortex of rats pre-treated with lithium
    Yuji Kitaichi
    Department of Psychiatry, Neural Function, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    Eur J Pharmacol 516:219-26. 2005
    ..Thus, lithium might augment the antidepressant effects of serotonin-noradrenaline reuptake inhibitors by augmenting serotonin release...
  25. doi request reprint Effect of co-administration of the selective 5-HT1A receptor antagonist WAY 100,635 and selective 5-HT1B/1D receptor antagonist GR 127,935 on anxiolytic effect of citalopram in conditioned fear stress in the rat
    Ihoko Muraki
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    Eur J Pharmacol 586:171-8. 2008
    ..15 mg/kg) or citalopram (3 mg/kg) alone, it is suggested that blocking 5-HT1A receptors is more effective in facilitating the anxiolytic effect of citalopram than blocking 5-HT1B/1D receptors...
  26. doi request reprint Effect of different challenge doses after repeated citalopram treatment on extracellular serotonin level in the medial prefrontal cortex: in vivo microdialysis study
    Ihoko Muraki
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Psychiatry Clin Neurosci 62:568-74. 2008
    ....
  27. ncbi request reprint [Clinical relevance of antidepressant-induced activation syndrome: from a perspective of bipolar spectrum disorder]
    Teruaki Tanaka
    Department of Psychiatry, Neural Function, Hokkaido University Graduate School of Medicine
    Seishin Shinkeigaku Zasshi 109:730-42. 2007
    ....
  28. ncbi request reprint Subchronic milnacipran treatment increases basal extracellular noradrenaline concentrations in the medial prefrontal cortex of rats
    Yuji Kitaichi
    Department of Psychiatry, Neural Function, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    Eur J Pharmacol 520:37-42. 2005
    ....
  29. ncbi request reprint Target brain sites of the anxiolytic effect of citalopram, a selective serotonin reuptake inhibitor
    Takeshi Izumi
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Eur J Pharmacol 534:129-32. 2006
    ..Among these regions the basolateral nucleus of the amygdala is a likely candidate region in which citalopram exerts its anxiolytic effect...
  30. doi request reprint Involvement of CaMKIV in neurogenic effect with chronic fluoxetine treatment
    Ning Song
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Int J Neuropsychopharmacol 16:803-12. 2013
    ..The behavioural effects of FLX in NSF were similar in both types. These data suggest that CaMKIV is involved in some aspects of FLX-promoting hippocampal neurogenesis...
  31. doi request reprint GDNF facilitates differentiation of the adult dentate gyrus-derived neural precursor cells into astrocytes via STAT3
    Shuken Boku
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Biochem Biophys Res Commun 434:779-84. 2013
    ..Taken together, our findings suggest that GDNF facilitates astrogliogenesis from neural precursor cells in adult DG through activating STAT3 and that this action might indirectly affect neurogenesis...
  32. doi request reprint Lamotrigine blocks repeated high-dose methamphetamine-induced behavioral sensitization to dizocilpine (MK-801), but not methamphetamine in rats
    Yasuya Nakato
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Japan
    Neurosci Lett 504:131-4. 2011
    ..Combined results of our previous studies and this study suggest that LTG is useful to treat schizophrenia, especially at a critical point in its progression...
  33. ncbi request reprint Effects of co-administration of antidepressants and monoamine oxidase inhibitors on 5-HT-related behavior in rats
    Takeshi Izumi
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo 060 8638, Japan
    Eur J Pharmacol 565:105-12. 2007
    ..Furthermore, the risk of 5-HT syndrome may be lower with the selective MAO-B inhibitor selegiline...
  34. ncbi request reprint 5-HT1A receptor agonist affects fear conditioning through stimulations of the postsynaptic 5-HT1A receptors in the hippocampus and amygdala
    XiaoBai Li
    Department of Psychiatry, Neural Function, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo, 060 8638, Japan
    Eur J Pharmacol 532:74-80. 2006
    ..These results suggest that flesinoxan exerts its anxiolytic actions in the fear conditioning through stimulations of the postsynaptic 5-HT(1A) receptors in the hippocampus and amygdala...
  35. ncbi request reprint [Biological basis of anxiety disorders and serotonergic anxiolytics]
    Takeshi Inoue
    Department of Psychiatry, Neural Function, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo, 060 8638 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 24:125-31. 2004
    ..Taken together, recent studies indicate that facilitation of brain serotonin neurotransmission decreases anxiety in agreement with the clinical evidence...
  36. doi request reprint ROCK2 regulates bFGF-induced proliferation of SH-SY5Y cells through GSK-3β and β-catenin pathway
    Shuken Boku
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Brain Res 1492:7-17. 2013
    ..Further investigation of detailed mechanisms regulating the ROCK2/GSK-3β/β-catenin pathway might engender the development of new therapeutic targets of psychiatric disorders...
  37. doi request reprint The effects of the co-administration of the α₁-adrenoreceptor antagonist prazosin on the anxiolytic effect of citalopram in conditioned fear stress in the rat
    Naoki Takamura
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 39:107-11. 2012
    ..These drugs did not affect the spontaneous motor activity of the rats. Therefore, these results suggest that blocking the α₁-adrenoreceptor decreases the anxiolytic effect of citalopram...
  38. doi request reprint Changes in amygdala neural activity that occur with the extinction of context-dependent conditioned fear stress
    Takeshi Izumi
    Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo 060 8638, Japan
    Pharmacol Biochem Behav 90:297-304. 2008
    ..Further, this is the first study to demonstrate that CREB phosphorylation in the basal nucleus of the amygdala changes in parallel with the extinction of context-dependent conditioned fear...
  39. ncbi request reprint Synergistic effects of tandospirone and selective serotonin reuptake inhibitors on the contextual conditioned fear stress response in rats
    Hiroyuki Nishikawa
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    Eur Neuropsychopharmacol 17:643-50. 2007
    ..These results elucidate the pharmacodynamic synergistic effects of tandospirone and SSRIs. Therefore, this augmentation therapy (SSRI+5-HT(1A) receptor agonist) may prove useful for some anxiety disorders...
  40. doi request reprint Valproate recovers the inhibitory effect of dexamethasone on the proliferation of the adult dentate gyrus-derived neural precursor cells via GSK-3β and β-catenin pathway
    Shuken Boku
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan Electronic address
    Eur J Pharmacol 723:425-30. 2014
    ..Therefore, GSK-3β and β-catenin pathway might play a role in the increasing effects of VPA on neurogenesis on adult DG. ..
  41. doi request reprint Noradrenaline increases neural precursor cells derived from adult rat dentate gyrus through β2 receptor
    Takahiro Masuda
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 36:44-51. 2012
    ..These results suggest that NA might increase the proliferation of early progenitor cells in adult hippocampus via β2-AR directly, but antidepressant drugs and 5-HT do not...
  42. ncbi request reprint Effect of mediodorsal thalamic nucleus lesion on contextual fear conditioning in rats
    Xiao Bai Li
    Department of Psychiatry, Graduate School of Medicine, Hokkaido University, North 15, West 7, Kita, Sapporo 060 8638, Japan
    Brain Res 1008:261-72. 2004
    ..Possible neural circuits, incorporating the amygdala, MD, and hippocampus, and the functional similarity of the MD and hippocampus in contextual fear conditioning, are also discussed...
  43. doi request reprint Glucocorticoids and lithium reciprocally regulate the proliferation of adult dentate gyrus-derived neural precursor cells through GSK-3beta and beta-catenin/TCF pathway
    Shuken Boku
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Neuropsychopharmacology 34:805-15. 2009
    ..These results suggest that GSK-3beta and beta-catenin/TCF pathway might be important in the reciprocal effects between DEX and Li on ADP proliferation and are new targets of therapeutic agents for stress-related disorders...
  44. doi request reprint The effect of dopamine on adult hippocampal neurogenesis
    Naoki Takamura
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan Pharmacology Research Laboratories, Dainippon Sumitomo Pharma Co, Ltd, Osaka, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 50:116-24. 2014
    ..These results suggested that DA might play, at least in part, a role in adult hippocampal neurogenesis via D1-like receptor and the activation of D1-like receptor has a therapeutic potential for depression. ..
  45. doi request reprint Retrieval of conditioned fear activates the basolateral and intercalated nucleus of amygdala
    Takeshi Izumi
    Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Neurosci Res 89:773-90. 2011
    ..It is therefore speculated that ITC GABAergic neurons were activated by retrieval of conditioned fear and that transcription factors other than c-Fos were relevant to the activation...
  46. doi request reprint Effects of acute citalopram on the expression of conditioned freezing in naive versus chronic citalopram-treated rats
    Shinji Hashimoto
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:113-7. 2009
    ..By prolonging the period between conditioning and exposure to conditioned fear stress, this model may have a more precise predictive validity of anxiety disorder as an animal model...
  47. doi request reprint Temperament and character profiles of Japanese university student suicide completers
    Nobuyuki Mitsui
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Compr Psychiatry 54:556-61. 2013
    ..The aims of this study were to investigate the personality traits of suicide completers using the Temperament and Character Inventory (TCI) scale...
  48. doi request reprint Temperament and character profiles of Japanese university students with depressive episodes and ideas of suicide or self-harm: a PHQ-9 screening study
    Nobuyuki Mitsui
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan Electronic address
    Compr Psychiatry 54:1215-21. 2013
    ..Furthermore, character traits of individuals with ideas of suicide or self-harm were also investigated in this study...
  49. ncbi request reprint Single footshock attenuates c-Fos expression induced by 5-HT2A receptor agonist (+/-)-2,5-dimethoxy-4-iodoamphetamine hydrochloride in rat brain
    Takeshi Izumi
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Neural Function, North 15, West 7, Sapporo 060 8638, Sapporo, Japan
    Brain Res 1011:129-34. 2004
    ..These changes in c-Fos expression suggest an adaptational change in the somatosensory cortex by acute stress...
  50. doi request reprint SSR504734, a glycine transporter-1 inhibitor, attenuates acquisition and expression of contextual conditioned fear in rats
    Hiroyuki Nishikawa
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Behav Pharmacol 21:576-9. 2010
    ..These findings indicate that SSR504734 attenuates both the acquisition and expression of contextual conditioned fear, and suggest that glycinergic neurotransmission may play an important role in conditioned fear...
  51. pmc Tricyclic antidepressant amitriptyline indirectly increases the proliferation of adult dentate gyrus-derived neural precursors: an involvement of astrocytes
    Shuken Boku
    Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, New York, United States of America Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    PLoS ONE 8:e79371. 2013
    ..These suggest that AMI may increase ADP proliferation indirectly via PCA and that FGF2 may a potential candidate to mediate such an indirect effect of AMI on ADP proliferation via astrocytes. ..
  52. doi request reprint Development and validation of a screening questionnaire for present or past (hypo)manic episodes based on DSM-IV-TR criteria
    Rie Kameyama
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    J Affect Disord 150:546-50. 2013
    ..This study was designed to determine the optimal screening methods to identify bipolar disorders among mood disorder patients of a psychiatric specialty clinic...
  53. pmc Differences between bipolar and unipolar depression on Rorschach testing
    Hiromi Kimura
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Neuropsychiatr Dis Treat 9:619-27. 2013
    ..This study was undertaken to compare bipolar and unipolar depression on Rorschach testing using the Comprehensive System with reference to healthy Japanese controls...
  54. doi request reprint Social Anxiety/Taijin-Kyofu Scale (SATS): development and psychometric evaluation of a new instrument
    Satoshi Asakura
    Health Care Center, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Psychopathology 45:96-101. 2012
    ..We developed the Social Anxiety/Taijin-Kyofu Scale (SATS), a 12-item structured clinician-rated instrument designed to rate the severity of TK symptoms, and examined its reliability and validity...
  55. doi request reprint Olanzapine augmentation of milnacipran for stage 2 treatment-resistant major depression: an open study
    Shuken Boku
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Hum Psychopharmacol 26:237-41. 2011
    ..However, studies of olanzapine augmentation of other antidepressants are few. We investigated the efficacy and safety of olanzapine augmentation of milnacipran, a serotonin-norepinephrine reuptake inhibitor, for TRD...
  56. pmc Effect of triiodothyronine (T(3)) augmentation of acute milnacipran administration on monoamine levels: an in vivo microdialysis study in rats
    Yuji Kitaichi
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Neuropsychiatr Dis Treat 8:501-7. 2012
    ..The administration of triiodothyronine (T(3)) to antidepressant nonresponders can be an effective augmentation strategy, although the mechanism is not fully understood...
  57. ncbi request reprint Long-lasting change in 5-HT2A receptor-mediated behavior in rats after a single footshock
    Takeshi Izumi
    Department of Psychiatry, Hokkaido University School of Medicine, North 15, West 7, Sapporo 060 8638, Japan
    Eur J Pharmacol 452:199-204. 2002
    ..Because there were no changes in the [3H]ketanserin binding of the frontal cortex 1 week after footshock, decreases in head shakes were not due to the down-regulation of 5-HT(2A) receptors evoked by footshock...
  58. doi request reprint Juvenile stress attenuates the dorsal hippocampal postsynaptic 5-HT1A receptor function in adult rats
    Hirokazu Matsuzaki
    Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo, 060, Japan
    Psychopharmacology (Berl) 214:329-37. 2011
    ..5-hydroxytryptamine (5-HT)(1A) receptors play a pivotal role in the 5-HTergic mechanisms associated with the etiology of stress-related disorders...
  59. doi request reprint Lamotrigine blocks the initiation and expression of repeated high-dose methamphetamine-induced prepulse inhibition deficit in rats
    Yasuya Nakato
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo, Hokkaido 060 8638, Japan
    Neurosci Lett 481:183-7. 2010
    ..Results suggest that LTG is useful for blocking progressive deterioration of neurocognitive function and recovering the neurocognitive deficit in schizophrenia...
  60. ncbi request reprint [Pharmacotherapy of anxiety disorders]
    Takeshi Inoue
    Department of Psychiatry, Hokkaido University Graduate School of Medicine
    Seishin Shinkeigaku Zasshi 114:1085-92. 2012
    ..Benzodiazepines also inhibit the amygdala, thereby reducing fear or anxiety. The inhibitory action on the amygdala might be a common mechanism of anti-anxiety action of SSRIs and benzodiazepines...
  61. doi request reprint Impaired integrity of the brain parenchyma in non-geriatric patients with major depressive disorder revealed by diffusion tensor imaging
    Khin K Tha
    Hokkaido University Graduate School of Medicine, Department of Radiobiology and Medical Engineering, N 15, W 7, Kita ku, Sapporo 060 8638, Japan
    Psychiatry Res 212:208-15. 2013
    ..These results suggest the implication of frontal-subcortical circuits and cerebellum in MDD, and the potential utility of FA in evaluation of brain parenchymal integrity...
  62. doi request reprint Adjunctive gabapentin for treatment-resistant insomnia of bipolar disorder: a case report
    Toshiaki Egashira
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Clin Neuropharmacol 34:129-30. 2011
    ..Results of this case suggest the clinical use of gabapentin for treating bipolar disorder, especially in cases with intractable insomnia, which is a very important point in the symptoms and therapeutics of bipolar disorder...
  63. ncbi request reprint [Anxiety disorder]
    Takeshi Inoue
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Brain Nerve 64:131-8. 2012
    ....
  64. ncbi request reprint Serotonin transporters
    Takeshi Inoue
    Department of Psychiatry, Hokkaido University, Graduate School of Medicine, Sapporo, Japan
    Curr Drug Targets CNS Neurol Disord 1:519-29. 2002
    ..This overview of recent studies of the serotonin transporters attempts to open new areas for discussion and define concepts not yet comprehensively reviewed...
  65. ncbi request reprint Effect of MS-153 on the development of behavioral sensitization to stereotypy-inducing effect of phencyclidine
    Tomohiro Abekawa
    Department of Psychiatry, Hokkaido University, Graduate School of Medicine Kita 15, Nishi 7, Sapporo, Japan
    Brain Res 926:176-80. 2002
    ..These results suggest that the attenuation of glutamatergic neural transmission enhances acute effect of PCP, but in contrast, blocks the behavioral sensitization to PCP...
  66. ncbi request reprint Olanzapine increases plasma ghrelin level in patients with schizophrenia
    Mari Murashita
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 14, West 7, Sapporo 060 8638, Japan
    Psychoneuroendocrinology 30:106-10. 2005
    ..To elucidate the mechanism of appetite and weight gain during olanzapine treatment, we investigated the circulating ghrelin levels...
  67. ncbi request reprint Effect of chronic treatment with the protein kinase C inhibitor staurosporine on the acquisition and expression of contextual fear conditioning
    Xiao Bai Li
    Department of Psychiatry, Graduate School of Medicine, Hokkaido University, North 15, West 7, Kita, Sapporo 060 8638, Japan
    Eur J Pharmacol 441:151-5. 2002
    ..1 mg/kg, but failed to affect the expression of conditioned freezing at any dose. These results suggest the involvement of protein kinase C in synaptic and cellular plasticity underlying emotional learning and memory...
  68. ncbi request reprint A prospective, open-label, flexible-dose study of quetiapine in the treatment of delirium
    Yukiya Sasaki
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Clin Psychiatry 64:1316-21. 2003
    ..The purpose of the present open-label, flexible-dose study was to provide preliminary data on the usefulness and safety of quetiapine for patients with delirium...
  69. ncbi request reprint Assessment of the dexamethasone/CRH test as a state-dependent marker for hypothalamic-pituitary-adrenal (HPA) axis abnormalities in major depressive episode: a Multicenter Study
    Hiroshi Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    Neuropsychopharmacology 31:212-20. 2006
    ..Restoration from HPA axis abnormalities occurred with clinical responses to treatment, particularly in depressed patients who underwent ECT...
  70. ncbi request reprint Addition of a dopamine agonist, cabergoline, to a serotonin-noradrenalin reuptake inhibitor, milnacipran as a therapeutic option in the treatment of refractory depression: two case reports
    Hitoshi Takahashi
    Department of Neuro Psychiatry, Akita University School of Medicine, 1 1 1 Hondo, Akita, Japan
    Clin Neuropharmacol 26:230-2. 2003
    ....
  71. ncbi request reprint Reconstruction of dopaminergic neural network and locomotion function in planarian regenerates
    Kaneyasu Nishimura
    Department of Neurobiology, 21st Century COE Program, Kyoto Pharmaceutical University, Kyoto 607 8414, Japan
    Dev Neurobiol 67:1059-78. 2007
    ..In DjTH-knockdown planarians, muscle-mediated locomotion and behavior were significantly attenuated. These results suggest that DA neurons play a key role in the muscle-mediated movement in planarians...
  72. ncbi request reprint [Therapeutic strategy for drug resistant depression]
    Takeshi Inoue
    Seishin Shinkeigaku Zasshi 106:1016-23. 2004
  73. ncbi request reprint Paradoxical brain embolism as a cause of central retinal artery occlusion: a case report
    Koji Hayashi
    Department of Stroke Medicine, Stroke Center, Kawasaki Medical School, Kurashiki City, Okayama, Japan
    J Neuroimaging 17:255-7. 2007
    ..No other embolic sources were identified in the carotid artery, aortic arch, or heart. We report herein a case of CRAO caused by paradoxical brain embolism...
  74. ncbi request reprint Antitumor efficacy of FK228, a novel histone deacetylase inhibitor, depends on the effect on expression of angiogenesis factors
    Yuka Sasakawa
    Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co, Ltd, 2 1 6 Kashima, Yodogawa ku, Osaka 532 8514, Japan
    Biochem Pharmacol 66:897-906. 2003
    ....
  75. ncbi request reprint Insulin-like growth factor-I prevents lethal acute liver failure induced by D-galactosamine and lipopolysaccharide in rats
    Takeshi Inoue
    Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co, Ltd, 2 1 6, Kashima, Yodogawa ku, Osaka 532 8514, Japan
    In Vivo 17:293-9. 2003
    ..Overall, this study showed that IGF-I treatment resulted in effective prevention of lethal acute liver failure in rats induced by GalN plus LPS, suggesting a therapeutic potential for IGF-I in the prevention of acute liver failure...
  76. ncbi request reprint A case of mesenteric lymphadenitis with long-acting symptom, showing marked response to corticosteroid
    Yuichiro Ikeda
    Department of Gastroenterology, Osaka City General Hospital
    Nihon Shokakibyo Gakkai Zasshi 104:1371-6. 2007
    ..She then developed erythema nodosum, suggesting the presence of autoimmune etiology. Treatment with systemic corticosteroid resulted in symptomatic improvement. Mesenteric lymphadenitis like this case is rare...
  77. ncbi request reprint [Clinical characteristics of paradoxical brain embolism associated with isolated pulmonary arteriovenous fistula]
    Kazumi Kimura
    Rinsho Shinkeigaku 42:849-54. 2002
    ....
  78. ncbi request reprint Depressive patients are more impulsive and inconsistent in intertemporal choice behavior for monetary gain and loss than healthy subjects--an analysis based on Tsallis' statistics
    Taiki Takahashi
    Unit of Cognitive and Behavioral Sciences, Department of Life Sciences, School of Arts and Sciences, The University of Tokyo, Komaba, Tokyo, 153 8902, Japan
    Neuro Endocrinol Lett 29:351-8. 2008
    ..This examination is potentially important for advances in neuroeconomics of intertemporal choice, because depression is associated with reduced serotonergic activities in the brain...
  79. ncbi request reprint Effects of FK228, a novel histone deacetylase inhibitor, on human lymphoma U-937 cells in vitro and in vivo
    Yuka Sasakawa
    Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co, Ltd, 2 1 6, Kashima, Yodogawa ku, Osaka 532 8514, Japan
    Biochem Pharmacol 64:1079-90. 2002
    ....
  80. ncbi request reprint [A case of amelanotic melanoma of the nasal cavity]
    Hisako Shibata
    Department of Hematology, Wakakoukai Hospital, Osaka 556 0005
    Rinsho Byori 50:712-6. 2002
    ..In many cases, it is difficult to diagnose amelanotic melanoma with HE staining alone, and immunohistochemistry must be used...
  81. doi request reprint Identification of a novel transcriptional corepressor, Corl2, as a cerebellar Purkinje cell-selective marker
    Yasuko Minaki
    KAN Research Institute Inc, KobeMI R and D Center, 6 7 3 Minatojima minamimachi, Chuo Ku, Kobe, Hyogo 650 0047, Japan
    Gene Expr Patterns 8:418-23. 2008
    ..Furthermore, this marker was useful for unmasking the precise origin of PCs and delineating the domain map within the ventricular zone that generates cerebellar GABAergic neurons...
  82. ncbi request reprint Identification and distribution of tryptophan hydroxylase (TPH)-positive neurons in the planarian Dugesia japonica
    Kaneyasu Nishimura
    Department of Neurobiology and 21st Century COE Program, Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
    Neurosci Res 59:101-6. 2007
    ..These results suggest that DjTPH is required for 5-HT biosynthesis, and DjTPH antibody is a useful marker for serotonergic neurons in planarians...
  83. ncbi request reprint Microembolic signals after 7 days but not within 24 hours of stroke onset should be predictor of stroke recurrence
    Yasuyuki Iguchi
    Department of Stroke Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki City, Okayama, 701 0192, Japan
    J Neurol Sci 263:54-8. 2007
    ..If MES is detectable at 7 days after stroke onset, embolic source lesions may still be active. We hypothesized that presence of MES at 7 days after stroke onset is strongly associated with stroke recurrence...
  84. ncbi request reprint Structure and function of primitive immunoglobulin superfamily neural cell adhesion molecules: a lesson from studies on planarian
    Eri Fusaoka
    Department of Biological Science, Nagoya University Graduate School of Science, Furocho, Chikusa ku, Nagoya 464 8602, Japan
    Genes Cells 11:541-55. 2006
    ..Functional analyses using RNA interference revealed that DjCAM is partly involved in axon formation, and that DjDSCAM plays crucial roles in neuronal cell migration, axon outgrowth, fasciculation and projection...
  85. ncbi request reprint Differential expression of ABCF2 protein among different histologic types of epithelial ovarian cancer and in clear cell adenocarcinomas of different organs
    Sadako Nishimura
    Department of Obstetrics and Gynecology, Osaka City General Hospital, Miyakojima, Osaka 534 0021, Japan
    Hum Pathol 38:134-9. 2007
    ..0001). These data suggest that ABCF2 protein may be a candidate marker for clear cell adenocarcinomas of the ovary and the uterine corpus and may be important for the pathogenesis of these diseases...
  86. ncbi request reprint Subcutaneous panniculitis-like T-cell lymphoma: successful initial treatment with prednisolone and cyclosporin A
    Yuka Tsukamoto
    Department of Internal Medicine, Osaka City General Hospital, Osaka
    Intern Med 45:21-4. 2006
    ..He responded to the treatment and remained asymptomatic for at least for 6 months. Our results suggest that a trial of cyclosporin A is warranted in patients with SPTCL complicated by HPS...
  87. ncbi request reprint Clathrin-mediated endocytic signals are required for the regeneration of, as well as homeostasis in, the planarian CNS
    Takeshi Inoue
    Group for Evolutionary Regeneration Biology, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Kobe, Japan
    Development 134:1679-89. 2007
    ..Thus, clathrin-mediated endocytic signals may be required for not only maintenance of neurons after synaptic formation, but also axonal extension at the early stage of neural differentiation...
  88. ncbi request reprint Rational design of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors: predicting enzyme conformational change and metabolism
    Tadashi Terasaka
    Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co, Ltd, 2 1 6, Kashima, Yodogawa ku, Osaka 532 8514, Japan
    J Med Chem 48:4750-3. 2005
    ..They demonstrated in vivo efficacy in models of inflammation and lymphoma. Furthermore, X-ray crystal structure analysis has revealed a novel induced fit to ADA...
  89. ncbi request reprint HOMER2 binds MYO18B and enhances its activity to suppress anchorage independent growth
    Rieko Ajima
    Biology Division, National Cancer Center Research Institute, 1 1, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Biochem Biophys Res Commun 356:851-6. 2007
    ..Expression of HOMER2 enhanced the ability of MYO18B to suppress anchorage-independent growth. These results indicate that HOMER2 and MYO18B cooperate together in tumor suppression...
  90. ncbi request reprint Effects of glucose abnormalities on in-hospital outcome after coronary intervention for acute myocardial infarction
    Masami Kosuge
    Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan
    Circ J 69:375-9. 2005
    ..We examined the association between glucose abnormalities and in-hospital outcome in patients undergoing PCI for acute myocardial infarction (AMI)...
  91. ncbi request reprint Regeneration-dependent conditional gene knockdown (Readyknock) in planarian: demonstration of requirement for Djsnap-25 expression in the brain for negative phototactic behavior
    Tomomi Takano
    Center for Developmental Biology, RIKEN Kobe, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
    Dev Growth Differ 49:383-94. 2007
    ..Our approach demonstrates that planarians are a powerful model organism to study the molecular basis of the brain as an information-processing center...
  92. ncbi request reprint [A case of intrapelvic retroperitoneal ganglioneuroma]
    Mitsuhiro Tambo
    Department of Urology, Nara Medical University
    Nihon Hinyokika Gakkai Zasshi 95:809-12. 2004
    ..Herein, we report this rare case of intrapelvic retroperitoneal ganglioneuroma, and present a brief review of the relevant literature including the present case...
  93. ncbi request reprint Structure-based design and synthesis of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors
    Tadashi Terasaka
    Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co, Ltd, 2 1 6, Kashima, Yodogawa ku, Osaka 532 8514, Japan
    J Med Chem 47:2728-31. 2004
    ..8 nM, BA = 42%)]. 6 demonstrated in vivo efficacy in models of inflammation and lymphoma...
  94. doi request reprint Lung cancer with localized ground-glass attenuation represents early-stage adenocarcinoma in nonsmokers
    Nobuhiko Seki
    Division of Medical Oncology, Department of Internal Medicine, Teikyo University School of Medicine, Itabashi ku, Tokyo, Japan
    J Thorac Oncol 3:483-90. 2008
    ..This study aimed to clarify the features of localized GGA cancer as a distinct clinicoradiological entity through a survey of lung cancers of all types...