Research Topics
Genomes and Genes | M HatakeyamaSummaryAffiliation: Hokkaido University Country: Japan Publications
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Publications
The role of Helicobacter pylori CagA in gastric carcinogenesisMasanori Hatakeyama
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
Int J Hematol 84:301-8. 2006....- Helicobacter pylori CagA -- a bacterial intruder conspiring gastric carcinogenesisMasanori Hatakeyama
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
Int J Cancer 119:1217-23. 2006..pylori-infected populations through cagA genotyping... - Helicobacter pylori CagA: a new paradigm for bacterial carcinogenesisMasanori Hatakeyama
Division of Molecular Oncology, Institute for Genetic Medicine and Division of Chemistry, Graduate School of Science, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 0815, Japan
Cancer Sci 96:835-43. 2005..pylori strains carrying biologically more active CagA are more virulent than those with less active CagA and are more closely associated with gastric carcinoma... - Oncogenic mechanisms of the Helicobacter pylori CagA proteinMasanori Hatakeyama
Division of Molecular Oncology, Institute for Genetic Medicine, Graduate School of Science, Hokkaido University, Sapporo 060 0815, Japan
Nat Rev Cancer 4:688-94. 2004..Intriguingly, CagA is noted for its variation, particularly at the SHP2-binding site, which could affect the potential of different strains of H. pylori to promote gastric carcinogenesis... - SagA of CagA in Helicobacter pylori pathogenesisMasanori Hatakeyama
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
Curr Opin Microbiol 11:30-7. 2008.... - Linking epithelial polarity and carcinogenesis by multitasking Helicobacter pylori virulence factor CagAM Hatakeyama
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
Oncogene 27:7047-54. 2008..These findings indicate that loss of cell polarity underlies the abnormal proliferation of epithelial cells that directs carcinogenesis... - Helicobacter pylori and gastric carcinogenesisMasanori Hatakeyama
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo, 060 0815, Japan
J Gastroenterol 44:239-48. 2009..Ectopically expressed AID may contribute to H. pylori-initiated gastric carcinogenesis by increasing the risk of likelihood of epithelial cells acquiring mutations in cancer-related genes... - EPIYA motif is a membrane-targeting signal of Helicobacter pylori virulence factor CagA in mammalian cellsHideaki Higashi
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
J Biol Chem 280:23130-7. 2005..pylori infection... - The CagA protein of Helicobacter pylori is translocated into epithelial cells and binds to SHP-2 in human gastric mucosaShiho Yamazaki
Second Department of Internal Medicine, Fukui Medical University, Japan
J Infect Dis 187:334-7. 2003..Deregulation of SHP-2 by CagA may play a role in the acquisition of a cellular-transformed phenotype at a relatively early stage of multistep gastric carcinogenesis... - SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA proteinHideaki Higashi
Division of Molecular Oncology, Institute for Genetic Medicine and Graduate School of Science, Hokkaido University, Sapporo 060 0815, Japan
Science 295:683-6. 2002..Conversely, the CagA effect on cells was reproduced by constitutively active SHP-2. Thus, upon translocation, CagA perturbs cellular functions by deregulating SHP-2... - Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activationHideaki Higashi
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo 060-0815, Japan
J Biol Chem 279:17205-16. 2004..Our work therefore suggests a key role of SHP-2 in the pathological activity of H. pylori virulence factor CagA... - Helicobacter pylori CagA--a potential bacterial oncoprotein that functionally mimics the mammalian Gab family of adaptor proteinsMasanori Hatakeyama
Division of Molecular Oncology and Institute for Genetic Medicine, Graduate School of Science, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 0815, Japan
Microbes Infect 5:143-50. 2003..CagA-SHP-2 interaction may play an important role in bacterial pathogenesis, leading to gastric carcinoma... - Collective inhibition of pRB family proteins by phosphorylation in cells with p16INK4a loss or cyclin E overexpressionS Ashizawa
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Kita-ku, Sapporo 060-0815, Japan
J Biol Chem 276:11362-70. 2001.... - Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagARyouhei Tsutsumi
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Sapporo 060 0815, Japan
Mol Cell Biol 26:261-76. 2006..Impaired cell adhesion and increased motility by CagA may be involved in the development of gastric lesions associated with cagA-positive H. pylori infection... - [Relationship between Helicobacter pylori CagA-SHP-2 interaction and gastric cancer]Masanori Hatakeyama
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University
Nippon Rinsho 63:48-52. 2005 - Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagAMasanori Naito
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
Gastroenterology 130:1181-90. 2006..Here we investigated the influence of EPIYA-repeat polymorphism on the CagA activity... - Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarityIraj Saadat
Division of Molecular Oncology, Institute for Genetic Medicine, Graduate School of Science, Hokkaido University, Sapporo 060 0815, Japan
Nature 447:330-3. 2007..Our findings revealed that PAR1 is a key target of H. pylori CagA in the disorganization of gastric epithelial architecture underlying mucosal damage, inflammation and carcinogenesis... - Differential oncogenic potential of geographically distinct Helicobacter pylori CagA isoforms in miceMotohiro Miura
Division of Molecular Oncology, Institute for Genetic Medicine, Graduate School of Science, Hokkaido University, Sapporo, Japan
Int J Cancer 125:2497-504. 2009..Differential oncogenic potential of geographically distinct CagA isoforms may contribute to the differential prevalence of gastric carcinoma between East Asian countries and Western countries... - Association between diversity in the Src homology 2 domain--containing tyrosine phosphatase binding site of Helicobacter pylori CagA protein and gastric atrophy and cancerTakeshi Azuma
Second Department of Internal Medicine, Fukui Medical University, Fukui, Japan
J Infect Dis 189:820-7. 2004..pylori is associated with atrophic gastritis and gastric cancer and that persistent active inflammation induced by the East Asian CagA-positive strain may play a role in the pathogenesis of disease... - Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cellsN Murata-Kamiya
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
Oncogene 26:4617-26. 2007..pylori CagA plays an important role in the development of intestinal metaplasia, a premalignant transdifferentiation of gastric epithelial cells from which intestinal-type gastric adenocarcinoma arises... - [Helicobacter pylori CagA and SHP-2 tyrosine phosphatase]Ryouhei Tsutumi
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo 060-0815, Japan
Seikagaku 77:1269-73. 2005 - Stability of Helicobacter pylori CagA oncoprotein in human gastric epithelial cellsSusumu Ishikawa
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 0815, Japan
FEBS Lett 583:2414-8. 2009..Furthermore, deletion of the PAR1-binding sequence accelerates CagA degradation. Thus, CagA is a relatively short half-life protein whose stability may be modulated through complex formation with PAR1... - Structural basis and functional consequence of Helicobacter pylori CagA multimerization in cellsShumei Ren
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Kita-15 Nishi-7, Kita-ku, Sapporo 060-0815, Japan
J Biol Chem 281:32344-52. 2006..The present work raises the possibility that inhibition of CagA multimerization abolishes pathophysiological activities of CagA that promote gastric carcinogenesis... - [Helicobacter pylori and gastric cancer]Masanori Hatakeyama
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Japan
Nippon Shokakibyo Gakkai Zasshi 104:635-43. 2007 - Structural and functional diversity in the PAR1b/MARK2-binding region of Helicobacter pylori CagAHuai Sheng Lu
Division of Molecular Oncology, Institute for Genetic Medicine, Graduate School of Science, Hokkaido University, Sapporo, Japan
Cancer Sci 99:2004-11. 2008..Our findings reveal that structural diversity in the CM sequence is an important determinant for the degree of virulence of CagA, a bacterial oncoprotein that is associated with gastric carcinogenesis... - Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sitesHideaki Higashi
Division of Molecular Oncology, Institute for Genetic Medicine, Graduate School of Science, Hokkaido University, Sapporo 060 0815, Japan
Proc Natl Acad Sci U S A 99:14428-33. 2002..The presence of distinctly structured CagA proteins in Western and East Asian H. pylori isolates may underlie the strikingly different incidences of gastric carcinoma in these two geographic areas... - Distinct diversity of the cag pathogenicity island among Helicobacter pylori strains in JapanTakeshi Azuma
Second Department of Internal Medicine, Faculty of Medical Science, University of Fukui Matsuoka cho, Yoshida gun, Fukui 910 1193, Japan
J Clin Microbiol 42:2508-17. 2004..These results suggest that a distinct diversity of the cag PAI of H. pylori is present among Japanese strains and that this diversity may be involved in the development of atrophic gastritis and may increase the risk for gastric cancer... - Attenuation of Helicobacter pylori CagA x SHP-2 signaling by interaction between CagA and C-terminal Src kinaseRyouhei Tsutsumi
Division of Molecular Oncology, Institute for Genetic Medicine, and Graduate School of Science, Hokkaido University, Sapporo 060-0185, Japan
J Biol Chem 278:3664-70. 2003..Attenuation of CagA activity by Csk may enable cagA-positive H. pylori to persistently infect the human stomach for decades while avoiding excess CagA toxicity to the host... - Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouseNaomi Ohnishi
Division of Molecular Oncology, Institute for Genetic Medicine, Graduate School of Science, Health Administration Center, Hokkaido University, Sapporo 060 0815, Japan
Proc Natl Acad Sci U S A 105:1003-8. 2008..pylori-associated neoplasms... - Functional antagonism between Helicobacter pylori CagA and vacuolating toxin VacA in control of the NFAT signaling pathway in gastric epithelial cellsKazuyuki Yokoyama
Institute for Genetic Medicine, Hokkaido University, Sapporo 060 0815, Japan
Proc Natl Acad Sci U S A 102:9661-6. 2005..pylori infection... - Helicobacter pylori CagA causes mitotic impairment and induces chromosomal instabilityMayumi Umeda
Division of Molecular Oncology, Institute for Genetic Medicine, Graduate School of Science, Laboratory of Pathophysiology and Signal Transduction, Hokkaido University, Sapporo, Japan
J Biol Chem 284:22166-72. 2009..The dual function of CagA may cooperatively contribute to the progression of multistep gastric carcinogenesis... - Development of a novel method to detect Helicobacter pylori cagA genotype from paraffin-embedded materials: comparison between patients with duodenal ulcer and gastric cancer in young JapaneseHiroyuki Ueda
Department of Medicine and Molecular Science, Hiroshima University, Hiroshima, Japan
Digestion 73:47-53. 2006..CONCLUSIONS: cagA polymorphism can be evaluated with the use of paraffin-embedded sections. The degree of corpus gastritis may not be regulated by cagA diversity only... - Identification of Helicobacter pylori and the cagA genotype in gastric biopsies using highly sensitive real-time PCR as a new diagnostic toolShiho Yamazaki
Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Matsuoka-cho, Yoshida-gun, Fukui 910-1193, Japan
FEMS Immunol Med Microbiol 44:261-8. 2005..3% (3/41) reacted with both types of cagA. These results suggest that this real-time PCR system provides a highly sensitive assessment of CagA type as a new diagnostic tool for the pathogenicity of H. pylori infection... - Activation of beta-catenin by carcinogenic Helicobacter pyloriAime T Franco
Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-2279, USA
Proc Natl Acad Sci U S A 102:10646-51. 2005..cag- strains or uninfected persons. These results indicate that H. pylori-induced dysregulation of beta-catenin-dependent pathways may explain in part the augmentation in the risk of gastric cancer conferred by this pathogen... - Helicobacter pylori CagA as a potential bacterial oncoprotein in gastric carcinogenesisMasanori Hatakeyama
Pathol Biol (Paris) 51:393-4. 2003 - O-ADP-Ribosylation in the NAD/NADase system: 2-alkanols as efficient substratesS Tono-Oka
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
Chem Pharm Bull (Tokyo) 49:123-5. 2001..This is the first report of O-ADP-ribosylation of terminal secondary alcohols with the NAD/NADase enzymatic system... - [Oncogenic mechanism of Helicobacter pylori]Masanori Hatakeyama
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Japan
Nihon Rinsho Meneki Gakkai Kaishi 31:132-40. 2008..The observations collectively indicate that H. pylori CagA is the first identified bacterial oncoprotein involved in gastric carcinogenesis... - Unusual enzymatic hydrolysis of NAD by solubilized form of NAD(+) glycohydrolaseShuichi Tono-oka
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
Chem Pharm Bull (Tokyo) 50:831-3. 2002.... - Deregulation of SHP-2 tyrosine phosphatase by the Helicobacter pylori virulence factor CagAMasanori Hatakeyama
Division of Molecular Oncology, Institute for Genetic Medicine and Graduate School of Science Hokkaido University, Sapporo, Japan
Keio J Med 51:26-32. 2002..Given the positive regulatory roles of SHP-2 in both cell proliferation and cell movement, the CagA-SHP-2 interaction may play an important role in the oncogenic transformation that is a hallmark of cagA+ H. pylori infection... - NF-kappa B-dependent induction of cyclin D1 by retinoblastoma protein (pRB) family proteins and tumor-derived pRB mutantsTetsuro Takebayashi
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo 060 0815, Japan
J Biol Chem 278:14897-905. 2003..Certain pRB pocket mutants may give rise to a cellular situation in which deregulated E2F and cyclin D1 cooperatively promote abnormal cell proliferation... - Pathogenesis of Helicobacter pylori infectionMasanori Hatakeyama
Division of Molecular Oncology Institute for Genetic Medicine Hokkaido University, Sapporo, Japan
Helicobacter 11:14-20. 2006..In addition, H. pylori infection triggers adhesion molecule expression and activity and produces an enhancement in oxidative stress interacting with gastric production of appetite hormone ghrelin and nonsteroidal anti-inflammatory drugs... - Downregulation of cyclin-dependent kinase inhibitor; p57(kip2), is involved in the cell cycle progression of vascular smooth muscle cellsNoritsugu Nakano
Department of Cardiovascular Medicine, Graduate School of Medicine, Hokkaido University, Sapporo 060 8638, Japan
Biochem Biophys Res Commun 338:1661-7. 2005..Our findings suggest that the downregulations of not only p27(kip1), but also p57(kip2) responding to mitogenic stimulation, play key roles in the cell cycle progression of VSMCs... - Deregulation of beta-catenin signal by Helicobacter pylori CagA requires the CagA-multimerization sequenceYo Kurashima
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
Int J Cancer 122:823-31. 2008..Our results indicate that aberrant activation of the beta-catenin signal, which promotes precancerous intestinal metaplasia, is an inherent and fundamental CagA activity that is independent of the structural polymorphism of CagA... - Conditional gene silencing utilizing the lac repressor reveals a role of SHP-2 in cagA-positive Helicobacter pylori pathogenicityMegumi Higuchi
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Kita-ku, Sapporo 060-0815, Japan
Cancer Sci 95:442-7. 2004..pylori CagA. The conditional gene silencing system described here should become a powerful tool for investigating the roles of cancer-related genes through a reversed genetic approach... - Role of partitioning-defective 1/microtubule affinity-regulating kinases in the morphogenetic activity of Helicobacter pylori CagAHuaisheng Lu
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo 060 0815, Japan
J Biol Chem 284:23024-36. 2009.... - Role of pRB-family/E2F complex in the inhibition of IL-3-dependent lymphoid cell proliferationMasafumi Yamada
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 0815, Japan
Cytokine 17:91-7. 2002..Our results indicate that blocking E2F-dependent transactivation, but not the formation of p130-E2F transcriptional repressor complexes, is responsible for the inhibition of IL-3-dependent cell growth by p130... - Meta-analysis of the relationship between CagA seropositivity and gastric cancerTakeshi Azuma
Gastroenterology 126:1926-7; author reply 1927-8. 2004 - The diversity of vacA and cagA genes of Helicobacter pylori in East AsiaWen Zhou
Second Department of Internal Medicine, Fukui Medical University, Matsuoka-cho, Yoshida-gun, Fukui 910-1193, Japan
FEMS Immunol Med Microbiol 40:81-7. 2004..These findings suggest that a distinct distribution of the vacA and cagA genotypes is present in East Asia, regardless of clinical outcome... - Involvement of pRB-related p107 protein in the inhibition of S phase progression in response to genotoxic stressT Kondo
Division of Molecular Oncology, Institute for Genetic Medicine, Department of Medicine II, School of Medicine, Hokkaido University, Kita-ku, Sapporo 060, Japan
J Biol Chem 276:17559-67. 2001..Because p107 is a major pRB family protein expressed in S phase cells, our results indicate that p107 participates in an inhibition of cell cycle progression in response to DNA damage in S phase cells... - Paired-like homeodomain protein ESXR1 possesses a cleavable C-terminal region that inhibits cyclin degradationHeita Ozawa
Division of Molecular Oncology, Institute for Genetic Medicine and Division of Chemistry, Graduate School of Science, Hokkaido University, Sapporo 060 0815, Japan
Oncogene 23:6590-602. 2004..Our results indicate that proteolytic processing of ESXR1 plays a role in concerted regulation of the cell cycle and transcription in human cells... - Effects of Helicobacter pylori CagA protein on the growth and survival of B lymphocytes, the origin of MALT lymphomaShintaro Umehara
Division of Molecular Oncology, Institute for Genetic Medicine and Graduate School of Science, Hokkaido University, Sapporo 060-0815, Japan
Oncogene 22:8337-42. 2003..As a result of B-cell growth inhibition, CagA may diminish anti-H. pylori immune responses. Furthermore, CagA may play a role in the development of MALT lymphoma by impairing p53-dependent apoptosis... - Distinct diversity of vacA, cagA, and cagE genes of Helicobacter pylori associated with peptic ulcer in JapanShiho Yamazaki
Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
J Clin Microbiol 43:3906-16. 2005..7%, 5/22) (chi2 = 12.64, P = 0.00057). These data suggest that the molecular genetics of vacA and cagPAI are associated and that the Western group with vacA and cagPAI genes is associated with peptic ulcer disease... - Isolation of a distinct class of gain-of-function SHP-2 mutants with oncogenic RAS-like transforming activity from solid tumorsD Miyamoto
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
Oncogene 27:3508-15. 2008..Although rare in solid tumors, the identified T507K SHP-2 represents a distinct class of SHP-2 mutants with oncogenic RAS-like transforming activity, which could contribute to the development of solid tumors... - Anti-tumor activity of ESX1 on cancer cells harboring oncogenic K-ras mutationJunta Nakajima
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 0815, Japan
Biochem Biophys Res Commun 370:189-94. 2008.... - Paired-like homeoprotein ESXR1 acts as a sequence-specific transcriptional repressor of the human K-ras geneMasatomo Yanagihara
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Kita ku, Sapporo, Japan
Oncogene 24:5878-87. 2005..Identification of ESXR1 as a transcriptional repressor of K-ras has an important implication for the development of cancer therapy that inhibits oncogenic K-Ras expression...