Research Topics
Species | Rie HasebeSummaryAffiliation: Hokkaido University Country: Japan Publications
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Detail Information
Publications
Reaction of complement factors varies with prion strains in vitro and in vivoRie Hasebe
Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institute of Health, Hamilton, MT 59840, USA
Virology 423:205-13. 2012..These results indicate that the reactivity of complement factors differs between prion strains both in vitro and in vivo...
Infectious entry of equine herpesvirus-1 into host cells through different endocytic pathwaysRie Hasebe
Laboratory of Prion Diseases, Graduate School of Veterinary Medicine, Hokkaido University, West 9 North 18, Kita ku, Sapporo 060 0818, Japan
Virology 393:198-209. 2009..Derm cells via energy- and pH-dependent endocytosis. These results suggest that EHV-1 utilizes multiple endocytic pathways in different cell types to establish productive infection...
Transcellular transport of West Nile virus-like particles across human endothelial cells depends on residues 156 and 159 of envelope proteinRie Hasebe
Department of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control, Kita 20, Nishi 10, Kita ku, Sapporo 001 0020, Japan
BMC Microbiol 10:165. 2010..Here, we analyzed the capacity of virus-like particles (VLPs) of the highly virulent NY99 6-LP strain (6-LP VLPs) and the low virulence Eg101 strain (Eg VLPs) to cross cultured human endothelial cells...
Equine major histocompatibility complex class I molecules act as entry receptors that bind to equine herpesvirus-1 glycoprotein DMichihito Sasaki
Department of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control, Sapporo 001 0020, Japan
Genes Cells 16:343-57. 2011..Derm cells drastically reduced their susceptibility to EHV-1 infection. These results suggest that equine MHC class I is a functional gD receptor that plays a pivotal role in EHV-1 entry into equine cells...
Single amino acid residue in the A2 domain of major histocompatibility complex class I is involved in the efficiency of equine herpesvirus-1 entryMichihito Sasaki
Department of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo 001 0020, Japan
J Biol Chem 286:39370-8. 2011..4 to mediate EHV-1 entry into cells. These results suggest that the amino acid residue at position 173 of the MHC class I molecule is involved in the efficiency of EHV-1 entry...
Therapeutic effect of peripheral administration of an anti-prion protein antibody on mice infected with prionsNatsuo Ohsawa
Laboratory of Veterinary Hygiene, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita ku, Sapporo, 060 0818
Microbiol Immunol 57:288-97. 2013..These results suggest that administration of an anti-PrP mAb through a peripheral route is a candidate for the treatment of prion diseases...
Characterization of intracellular localization of PrP(Sc) in prion-infected cells using a mAb that recognizes the region consisting of aa 119-127 of mouse PrPTakeshi Yamasaki
Laboratory of Veterinary Hygiene, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita ku, Sapporo 060 0818, Japan
J Gen Virol 93:668-80. 2012....
The region approximately between amino acids 81 and 137 of proteinase K-resistant PrPSc is critical for the infectivity of the Chandler prion strainRyo Shindoh
Laboratory of Prion Diseases, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita ku, Sapporo 060 0818, Japan
J Virol 83:3852-60. 2009..This finding suggests that the conformation of the region between aa 81 and 137 of the Chandler strain PrP(Sc) molecule is directly associated with prion infectivity...
Propagation of swine hemagglutinating encephalomyelitis virus and pseudorabies virus in dorsal root ganglia cellsYoko Hara
Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
J Vet Med Sci 71:595-601. 2009....
Effect of intraventricular infusion of anti-prion protein monoclonal antibodies on disease progression in prion-infected miceChang Hyun Song
Laboratory of Prion Diseases, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita ku, Sapporo 060 0818, Japan
J Gen Virol 89:1533-44. 2008..Although the effects on survival varied for different prion strains, the anti-PrP mAb could partly prevent disease progression, even after clinical onset, suggesting immunotherapy as a candidate for treatment of prion diseases...
Passage of equine herpesvirus-1 in suckling mouse brain enhances extraneural virus growth and subsequent hematogenous neuroinvasionRie Hasebe
Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
J Vet Med Sci 64:907-12. 2002..i. These results suggest that NHH1 neuroinvasion is hematogenous and is correlated with enhanced extraneural virus growth...
Effect of transplantation of bone marrow-derived mesenchymal stem cells on mice infected with prionsChang Hyun Song
Laboratory of Prion Diseases, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
J Virol 83:5918-27. 2009....
Cell density-dependent increase in the level of protease-resistant prion protein in prion-infected Neuro2a mouse neuroblastoma cellsSatoshi Nakamitsu
Laboratory of Prion Diseases, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita ku, Sapporo 060 0818, Japan
J Gen Virol 91:563-9. 2010..The cholesterol content, which is known to influence PrP-res formation, also changed depending on cell density. Our data suggest that alterations in cellular microenvironments controlled by cell density influence PrP-res formation...
