H Hara

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. ncbi request reprint Lymphatic absorption of plasmalogen in rats
    Hiroshi Hara
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita 9, Nishi 9, Kitaku, Sapporo 060 8589, Japan
    Br J Nutr 90:29-32. 2003
  2. pmc Dietary fat and bile juice, but not obesity, are responsible for the increase in small intestinal permeability induced through the suppression of tight junction protein expression in LETO and OLETF rats
    Takuya Suzuki
    Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University, Sapporo, Hokkaido, Japan
    Nutr Metab (Lond) 7:19. 2010
  3. doi request reprint Difructose anhydride III promotes iron absorption in the rat large intestine
    Hiroshi Hara
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    Nutrition 26:120-7. 2010
  4. ncbi request reprint Differential increases in syntheses of newly identified trypsinogen 2 isoforms by dietary protein in rat pancreas
    Hiroshi Hara
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
    Exp Biol Med (Maywood) 229:772-80. 2004
  5. ncbi request reprint Difructose anhydrides III and IV equally promote calcium absorption from the luminally perfused rat small intestine
    Hiroshi Hara
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
    Biosci Biotechnol Biochem 69:839-41. 2005
  6. ncbi request reprint Endogenous cholecystokinin plays a role in down-regulation of pancreatic amylase independent of dietary carbohydrate in rats
    H Hara
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University Kita 9, Nishi 9, Kita ku, 060 8589, Sapporo, Japan
    Regul Pept 99:103-10. 2001
  7. ncbi request reprint Ingestion of the soluble dietary fibre, polydextrose, increases calcium absorption and bone mineralization in normal and total-gastrectomized rats
    H Hara
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
    Br J Nutr 84:655-61. 2000
  8. ncbi request reprint Ingestion of guar-gum hydrolysate partially restores calcium absorption in the large intestine lowered by suppression of gastric acid secretion in rats
    H Hara
    Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo, Japan
    Br J Nutr 81:315-21. 1999
  9. ncbi request reprint Luminal dietary protein, not amino acids, induces pancreatic protease via CCK in pancreaticobiliary-diverted rats
    H Hara
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
    Am J Physiol Gastrointest Liver Physiol 278:G937-45. 2000
  10. ncbi request reprint Intestinal fat suppresses protein-induced exocrine pancreatic secretion in chronically bile-pancreatic juice-diverted rats
    H Hara
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    Proc Soc Exp Biol Med 223:276-81. 2000

Collaborators

Detail Information

Publications100

  1. ncbi request reprint Lymphatic absorption of plasmalogen in rats
    Hiroshi Hara
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita 9, Nishi 9, Kitaku, Sapporo 060 8589, Japan
    Br J Nutr 90:29-32. 2003
    ..We conclude that a small percentage but a significant amount of the plasmalogen was absorbed into the lymph...
  2. pmc Dietary fat and bile juice, but not obesity, are responsible for the increase in small intestinal permeability induced through the suppression of tight junction protein expression in LETO and OLETF rats
    Takuya Suzuki
    Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University, Sapporo, Hokkaido, Japan
    Nutr Metab (Lond) 7:19. 2010
    ..The present study was performed to determine the influence of obesity itself as well as dietary fat on the increase in intestinal permeability...
  3. doi request reprint Difructose anhydride III promotes iron absorption in the rat large intestine
    Hiroshi Hara
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    Nutrition 26:120-7. 2010
    ..We examined the intestinal segment responsible for and the mechanisms involved in the non-digestible disaccharide difructose anhydride III (DFAIII)-mediated enhancement of iron absorption...
  4. ncbi request reprint Differential increases in syntheses of newly identified trypsinogen 2 isoforms by dietary protein in rat pancreas
    Hiroshi Hara
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
    Exp Biol Med (Maywood) 229:772-80. 2004
    ..We conclude that increases in synthesis of a few newly identified trypsinogen 2-x isoforms mainly contribute to the induction of trypsin activity in the pancreas by HC in PBD rats...
  5. ncbi request reprint Difructose anhydrides III and IV equally promote calcium absorption from the luminally perfused rat small intestine
    Hiroshi Hara
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
    Biosci Biotechnol Biochem 69:839-41. 2005
    ..15 ml/min than at 0.3 ml/min. The promotive effects were higher in the duodenojejunum than in the ileum...
  6. ncbi request reprint Endogenous cholecystokinin plays a role in down-regulation of pancreatic amylase independent of dietary carbohydrate in rats
    H Hara
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University Kita 9, Nishi 9, Kita ku, 060 8589, Sapporo, Japan
    Regul Pept 99:103-10. 2001
    ..The effect of CCK on amylase production is independent of regulation by dietary carbohydrate...
  7. ncbi request reprint Ingestion of the soluble dietary fibre, polydextrose, increases calcium absorption and bone mineralization in normal and total-gastrectomized rats
    H Hara
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
    Br J Nutr 84:655-61. 2000
    ..These results suggest that the small intestine rather than the large intestine is responsible for the increase in Ca absorption in rats fed PD, and suggests that the mechanism for the increase by PD may be different from that by GGH...
  8. ncbi request reprint Ingestion of guar-gum hydrolysate partially restores calcium absorption in the large intestine lowered by suppression of gastric acid secretion in rats
    H Hara
    Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo, Japan
    Br J Nutr 81:315-21. 1999
    ..We conclude that Ca absorption lowered by inhibition of gastric acid secretion is partially restored in rats fed with GGH, but the increment is not sufficient to meet requirements...
  9. ncbi request reprint Luminal dietary protein, not amino acids, induces pancreatic protease via CCK in pancreaticobiliary-diverted rats
    H Hara
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
    Am J Physiol Gastrointest Liver Physiol 278:G937-45. 2000
    ..The induction was found to be dependent on the direct action of CCK on the pancreas. Pancreatic growth induced by high-protein feeding in PBD rats may depend at least partly on absorbed amino acids...
  10. ncbi request reprint Intestinal fat suppresses protein-induced exocrine pancreatic secretion in chronically bile-pancreatic juice-diverted rats
    H Hara
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    Proc Soc Exp Biol Med 223:276-81. 2000
    ....
  11. ncbi request reprint Changes in messenger RNA of pancreatic enzymes and intestinal cholecystokinin after a 7-day bile-pancreatic juice diversion from the proximal small intestine in rats
    H Hara
    Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo, Japan
    Biosci Biotechnol Biochem 61:1002-6. 1997
    ..These results suggest that intestinal cholecystokinin was predominantly increased at the translational or later stage by chronic BPJ diversion...
  12. ncbi request reprint A protein less sensitive to trypsin, guanidinated casein, is a potent stimulator of exocrine pancreas in rats
    H Hara
    Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo, Japan
    Proc Soc Exp Biol Med 210:278-84. 1995
    ..Also, in normal rats, the luminal protease-independent mechanism may play a role partly in increasing the pancreatic secretion by dietary protein...
  13. ncbi request reprint Guanidinated casein hydrolysate stimulates pancreatic secretagogue release by direct action to the intestine in rats
    T Nishi
    Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo, Japan
    Proc Soc Exp Biol Med 218:357-64. 1998
    ..We conclude that in rats with BPJ diversion, HGC stimulates CCK release from the intestine by direct action on intestinal mucosa...
  14. ncbi request reprint Effect of a phosphorylated guar gum hydrolysate on increased calcium solubilization and the promotion of calcium absorption in rats
    O Watanabe
    Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo, Japan
    Biosci Biotechnol Biochem 64:160-6. 2000
    ..These results indicate that P-GGH may inhibit calcium phosphate formation in the lower part of the small intestine, and thus increase calcium absorption...
  15. ncbi request reprint Two-week feeding of difructose anhydride III enhances calcium absorptive activity with epithelial cell proliferation in isolated rat cecal mucosa
    Hitoshi Mineo
    Northern Advancement Center for Science and Technology, Colabo Hokkaido, Sapporo, Japan
    Nutrition 22:312-20. 2006
    ..The short-term and long-term effects of DFAIII feeding on Ca transport were determined by using isolated epithelium from the small and large intestine in rats...
  16. ncbi request reprint Increased intestinal calcium absorption from the ingestion of a phosphorylated guar gum hydrolysate independent of cecal fermentation in rats
    O Watanabe
    Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo, Japan
    Biosci Biotechnol Biochem 64:613-6. 2000
    ..The calcium solubility in the ileum was increased in those rats fed on P-GGH. We conclude that cecal fermentation did not contribute to the increased calcium absorption by the rats fed on P-GGH...
  17. ncbi request reprint The large intestine compensates for insufficient calcium absorption in the small intestine in rats
    K Shiga
    Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo, Japan
    J Nutr Sci Vitaminol (Tokyo) 44:737-44. 1998
    ..2% Ca diet containing an insoluble Ca salt (carbonate), Ca is not sufficiently absorbed in the small intestine. However, the large intestine compensates for the small intestinal Ca absorption decreased by dietary secondary phosphates...
  18. ncbi request reprint Stimulative effect of a casein hydrolysate on exocrine pancreatic secretion that is independent of luminal trypsin inhibitory activity in rats
    T Hira
    Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo, Japan
    Biosci Biotechnol Biochem 63:1192-6. 1999
    ..These results demonstrate that dietary protein enhances pancreatic secretion independently of the masking of luminal trypsin activity in rats...
  19. ncbi request reprint Massive large bowel resection decreases bone strength and magnesium content but not calcium content of the femur in rats
    K Shiga
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    Nutrition 17:397-402. 2001
    ..Femoral breaking force was positively correlated (r = 0.617, P = 0.011) with only the magnesium content. We conclude that the changes in magnesium kinetics caused by cecocolonectomy could contribute to the fragility of bone...
  20. doi request reprint Prebiotic properties of epilactose
    J Watanabe
    Creative Research Initiative Sousei, Hokkaido University, Sapporo 001 0021, Japan
    J Dairy Sci 91:4518-26. 2008
    ..Cellobiose 2-epimerase may increase the value of dairy products by changing lactose to epilactose possessing prebiotic properties...
  21. ncbi request reprint Enteral administration of soybean lecithin enhanced lymphatic absorption of triacylglycerol in rats
    Megumi Nishimukai
    Graduate School of Agriculture, Hokkaido University, Kita 9, Nishi 9, Kita ku, Sapporo 060 8589, Japan
    Br J Nutr 90:565-71. 2003
    ..These present results demonstrate that a TG emulsion containing soyabean lecithin or its hydrolysates promote lymphatic TG output and suggest that the increases in TG absorption do not depend on TG digestion...
  22. ncbi request reprint Promotive effects of non-digestible disaccharides on rat mineral absorption depend on the type of saccharide
    Patchana Asvarujanon
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    Nutrition 21:1025-35. 2005
    ....
  23. ncbi request reprint Ingestion of raffinose promotes calcium absorption in the large intestine of rats
    Rieko Mitamura
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    Biosci Biotechnol Biochem 68:384-9. 2004
    ..The impaired absorption in ovariectomized rats was restored by feeding raffinose. The large intestine is involved in the beneficial effects of raffinose...
  24. ncbi request reprint Characterization of binding between the rat small intestinal brush-border membrane and dietary proteins in the sensory mechanism of luminal dietary proteins
    T Hira
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    Biosci Biotechnol Biochem 65:1007-15. 2001
    ..These binding intensities for proteins were closely correlated to physiological responsiveness, and are possibly involved in a sensory system for dietary protein in the intestine...
  25. ncbi request reprint L-homoarginine suppresses exocrine pancreas in rats
    T Hira
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita ku, Sapporo, Japan
    Amino Acids 24:389-96. 2003
    ..These results indicate that L-homoarginine has an inhibitory effect on the secretion and production of exocrine pancreatic enzyme in BPJ-diverted rats, and L-homoarginine may have an antagonistic effect on CCK receptors...
  26. ncbi request reprint Adrenaline-induced lipolysis in isolated rat mesenteric adipocytes is higher in the large intestine than in the small intestine
    Aki Shinoki
    Laboratory of Nutritional Biochemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Hokkaido, Japan
    Biosci Biotechnol Biochem 74:670-2. 2010
    ..Intestinal bacteria or their metabolites possibly contributed to this phenomenon...
  27. ncbi request reprint Ingestion of insoluble dietary fibre increased zinc and iron absorption and restored growth rate and zinc absorption suppressed by dietary phytate in rats
    K Hayashi
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan
    Br J Nutr 86:443-51. 2001
    ....
  28. doi request reprint Long-term oral administration of cows' milk improves insulin sensitivity in rats fed a high-sucrose diet
    Megumi Matsumoto
    Meiji Dairies Research Chair, Creative Research Initiative Sousei CRIS, Hokkaido University, Sapporo, Hokkaido, Japan
    Br J Nutr 102:1324-33. 2009
    ..Improved insulin sensitivity due to CM administration seemed to be associated with reduced duodenal GLUT2 mRNA levels and increased propionate production within the caecum...
  29. ncbi request reprint Fermentable dietary fiber potentiates the localization of immune cells in the rat large intestinal crypts
    Satoshi Ishizuka
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
    Exp Biol Med (Maywood) 229:876-84. 2004
    ..There was a significant relationship between SCFA and the localization of immune cells, especially CD8(+) IEL and CD161(+) NK cells, which are considered to be involved in the maintenance of epithelial homeostasis...
  30. ncbi request reprint Sucrose fatty acid esters suppress pancreatic secretion accompanied by peptide YY release in pancreatico-biliary diverted rats
    Tohru Hira
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita 9, Nishi 9, Kita ku, Sapporo 060 8589, Japan
    Exp Physiol 92:687-94. 2007
    ..These results suggest that the esterified fatty acid itself stimulates PYY release in the distal intestine, thereby inhibiting protein-induced pancreatic secretion...
  31. doi request reprint Calcium-sensing receptor mediates phenylalanine-induced cholecystokinin secretion in enteroendocrine STC-1 cells
    Tohru Hira
    Division of Applied Biosciences, Research Faculty of Agriculture, Hokkaido University, Sapporo, Japan
    FEBS J 275:4620-6. 2008
    ..In conclusion, CaR functions as a receptor for Phe, stimulating CCK secretion in enteroendocrine STC-1 cells...
  32. doi request reprint Synbiotic promotion of epithelial proliferation by orally ingested encapsulated Bifidobacterium breve and raffinose in the small intestine of rats
    Satoshi Ishizuka
    Laboratory of Nutritional Biochemistry, Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University, Kita 9 Nishi 9, Kita ku, Sapporo, Hokkaido 060 8589, Japan
    Mol Nutr Food Res 53:S62-7. 2009
    ..breve in combination with raffinose on epithelial proliferation in rat small intestine but not in large intestine. To our knowledge, this is the first report of a synbiotic that affects epithelial proliferation...
  33. ncbi request reprint Soybean phosphatidylcholine-induced enhancement of lymphatic absorption of triglyceride depends on chylomicron formation in rats
    Megumi Nishimukai
    Creative Research Initiative Sousei, Hokkaido University, Sapporo, Japan
    Biosci Biotechnol Biochem 71:1192-7. 2007
    ..We conclude that the formation of chylomicron is responsible for increases in the promotive effect of a high level of dietary PC on the lymphatic absorption of TG...
  34. doi request reprint Cholecystokinin secretion induced by beta-conglycinin peptone depends on Galphaq-mediated pathways in enteroendocrine cells
    Tohru Hira
    Division of Applied Biosciences, Research Faculty of Agriculture, Hokkaido University, Kita 9, Nishi 9, Kita ku, Sapporo 060 8589, Japan
    Eur J Nutr 48:124-7. 2009
    ..However, the sensing mechanism of BconP by CCK-producing cells is unknown...
  35. ncbi request reprint Production of equol from daidzein by gram-positive rod-shaped bacterium isolated from rat intestine
    Kimiko Minamida
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita 9, Nishi 9, Sapporo, Hokkaido, Japan
    J Biosci Bioeng 102:247-50. 2006
    ..This strain converted daidzein to equol via dihydrodaidzein in an equol-assay medium anaerobically. The addition of butyric acid and arginine increased the conversion ratio of daidzein to equol 4.7- and 4.5-fold, respectively...
  36. doi request reprint Soybean beta 51-63 peptide stimulates cholecystokinin secretion via a calcium-sensing receptor in enteroendocrine STC-1 cells
    Shingo Nakajima
    Division of Bio systems and Sustainability, Graduate School of Agriculture, Hokkaido University, Kita 9, Nishi 9, Kita ku, Sapporo 060 8589, Japan
    Regul Pept 159:148-55. 2010
    ..From these results, we conclude that CaR is the beta 51-63 peptide sensor responsible for the stimulation of CCK secretion in enteroendocrine STC-1 cells...
  37. ncbi request reprint Supplemental feeding of difructose anhydride III restores calcium absorption impaired by ovariectomy in rats
    Rieko Mitamura
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
    J Nutr 132:3387-93. 2002
    ..5 and 3% DFAIII groups than in the PEG group. In conclusion, ovarian hormone deficiency impaired Ca absorption, but the reduction of Ca absorption was restored by feeding DFAIII...
  38. doi request reprint Calcium deficiency in the early stages after weaning is associated with the enhancement of a low level of adrenaline-stimulated lipolysis and reduction of adiponectin release in isolated rat mesenteric adipocytes
    Aki Shinoki
    Laboratory of Nutritional Biochemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Hokkaido, Japan
    Metabolism 59:951-8. 2010
    ..Our present results suggest that a low intake of Ca in the early stages after weaning is associated with changes in the properties of mesenteric adipocytes, which may be linked to insulin resistance in the future...
  39. ncbi request reprint Sugar alcohols enhance calcium transport from rat small and large intestine epithelium in vitro
    Hitoshi Mineo
    Hokkaido Foundation for the Promotion of Scientific and Industrial Technology, Colabo Hokkaido, Sapporo, Japan
    Dig Dis Sci 47:1326-33. 2002
    ..We concluded that sugar alcohols directly affect the epithelial tissue and promote Ca absorption from the small and large intestine in vitro...
  40. doi request reprint Suppressive effects of the marine carotenoids, fucoxanthin and fucoxanthinol on triglyceride absorption in lymph duct-cannulated rats
    Megumi Matsumoto
    Creative Research Initiative Sousei CRIS, Hokkaido University, Kita 21, Nishi 10, Kita ku, Sapporo, Hokkaido, 001 0021, Japan
    Eur J Nutr 49:243-9. 2010
    ..Fucoxanthin isolated from edible seaweeds and its metabolite fucoxanthinol have been recently found to have anti-obesity effects, but the mechanism is not fully understood...
  41. doi request reprint Asaccharobacter celatus gen. nov., sp. nov., isolated from rat caecum
    Kimiko Minamida
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Hokkaido 060 8589, Japan
    Int J Syst Evol Microbiol 58:1238-40. 2008
    ..Therefore, the strain constitutes a novel genus and species, for which the name Asaccharobacter celatus gen. nov., sp. nov. is proposed. The type strain of the type species is do03T (=JCM 14811T=DSM 18785T=AHU 1763T)...
  42. ncbi request reprint Dietary amino acids promote pancreatic protease synthesis at the translation stage in rats
    Naoto Hashimoto
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
    J Nutr 133:3052-7. 2003
    ..These results indicate that dietary AA induce chymotrypsin synthesis by promoting translation, and transient activation of translation initiation via mTOR may be associated with this induction...
  43. ncbi request reprint Administration of anti-glucagon-like peptide-2 serum suppresses epithelial cell proliferation of the distal small intestine in weanling rats
    Satoshi Ishizuka
    Hokkaido University, Sapporo, Japan
    Biomed Res 30:259-61. 2009
    ..These results suggest that intrinsic GLP-2 contributes to the growth of the small intestine during the weanling period...
  44. ncbi request reprint Improved isolation methods for mucosal leukocytes from small and large intestines in rats
    Jae Sung Lee
    Laboratory of Nutritional Biochemistry, Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University, Sapporo, Japan
    Biosci Biotechnol Biochem 73:1732-40. 2009
    ....
  45. doi request reprint GLP-1 secretion is enhanced directly in the ileum but indirectly in the duodenum by a newly identified potent stimulator, zein hydrolysate, in rats
    Tohru Hira
    Division of Applied Biosciences, Research Faculty of Agriculture, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    Am J Physiol Gastrointest Liver Physiol 297:G663-71. 2009
    ..These results indicate that a potent GLP-1-releasing peptide, ZeinH, induces GLP-1 secretion by direct and indirect mechanisms in the rat intestine...
  46. ncbi request reprint Ingestion of water-soluble soybean fiber improves gastrectomy-induced calcium malabsorption and osteopenia in rats
    Kazuki Shiga
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita 9, Nishi 9, Kita ku, Sapporo 060 8589, Japan
    Nutrition 18:636-42. 2002
    ..We examined the effects of feeding water-soluble soybean fiber (WSSF), a highly fermentable dietary fiber with low viscosity, on calcium absorption and bone characteristics in totally gastrectomized rats...
  47. ncbi request reprint Short-chain fatty acids enhance diffusional ca transport in the epithelium of the rat cecum and colon
    H Mineo
    Hokkaiodo Foundation for the Promotion of Scientific and Industrial Technology, Colabo-Hokkaido, Sapporo, Japan
    Life Sci 69:517-26. 2001
    ..We concluded that SCFAs affect the epithelial tissue and promote Ca absorption from the large intestine in vitro. The enhancement of Ca transport induced by SCFAs might be involved in the paracellular transport mechanism...
  48. ncbi request reprint Ingestion of difructose anhydride III, a non-digestible disaccharide, prevents gastrectomy-induced iron malabsorption and anemia in rats
    Kazuki Shiga
    Northern Advancement Center for Scientific and Technology, Hokkaido University, Sapporo, Japan
    Nutrition 22:786-93. 2006
    ....
  49. ncbi request reprint Pork peptone stimulates cholecystokinin secretion from enteroendocrine cells and suppresses appetite in rats
    M K N B Sufian
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    Biosci Biotechnol Biochem 70:1869-74. 2006
    ..These results suggest that PorkP interacts directly with the small intestinal CCK cells to release CCK, and that it suppresses appetite in rats...
  50. ncbi request reprint Intestinal absorption and metabolism of a soluble flavonoid, alphaG-rutin, in portal cannulated rats
    Mgumi Matsumoto
    Fuji Women s University, Faculty of Human Life Science, Department of Food Science and Human Nutrition, Ishikari, Hokkaido, 061 3204, Japan
    Free Radic Res 39:1139-46. 2005
    ..In conclusion, a soluble flavonoid-glycoside, alphaG-rutin, was absorbed as glycosides into the portal blood. A part of alphaG-rutin was hydrolyzed to rutin, but not to aglycone, through the intestine...
  51. doi request reprint The nondigestible disaccharide epilactose increases paracellular Ca absorption via rho-associated kinase- and myosin light chain kinase-dependent mechanisms in rat small intestines
    Takuya Suzuki
    Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University Kita 9, Nishi 9, Kita ku, Sapporo 060 8589, Japan
    J Agric Food Chem 58:1927-32. 2010
    ..These results indicate that epilactose increases paracellular Ca absorption in the small intestine of rats through the induction of MLC phosphorylation via MLCK- and ROCK-dependent mechanisms...
  52. doi request reprint Oligosaccharide promotes bioavailability of a water-soluble flavonoid glycoside, alpha G-rutin, in rats
    Noriko Matsukawa
    Laboratory of Nutritional Biochemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Hokkaido 060 8589, Japan
    J Agric Food Chem 57:1498-505. 2009
    ..It was concluded that suppression of degrading quercetin aglycone in the large intestine has a major role for increasing alpha G-rutin bioavailability by DFA III and FOS feedings...
  53. doi request reprint Physiological concentrations of short-chain fatty acids immediately suppress colonic epithelial permeability
    Takuya Suzuki
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    Br J Nutr 100:297-305. 2008
    ..We conclude that physiological concentrations of SCFA immediately enhance barrier function of the colonic epithelium through cholesterol-rich microdomain in the plasma membrane...
  54. doi request reprint Effects of epilactose on calcium absorption and serum lipid metabolism in rats
    Megumi Nishimukai
    Creative Research Initiative Sousei, Hokkaido University, N21W10 Kita ku, Sapporo 001 0021, Japan
    J Agric Food Chem 56:10340-5. 2008
    ..These results indicate that epilactose promotes calcium absorption in the small intestine and possibly lowers the risk of arteriosclerosis. Cecal microbes may efficiently utilize epilactose and contribute to these biological activities...
  55. ncbi request reprint Dietary branched-chain amino acids suppress the expression of pancreatic amylase mRNA in rats
    Naoto Hashimoto
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    Biosci Biotechnol Biochem 68:1067-72. 2004
    ..The mRNA levels correlated with individual pancreatic BCAA concentrations but not with plasma insulin level. In conclusion, dietary BCAA, especially leucine and isoleucine, may reduce amylase mRNA and activity in rats...
  56. ncbi request reprint Ingestion of plasmalogen markedly increased plasmalogen levels of blood plasma in rats
    Megumi Nishimukai
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kitaku, Sapporo 060 8589, Japan
    Lipids 38:1227-35. 2003
    ..We concluded that dietary plasmalogen is absorbed from the intestine and contributes to a large increase in plasmalogen levels in blood plasma...
  57. ncbi request reprint Ingestion of difructose anhydride III partially restores calcium absorption impaired by vitamin D and estrogen deficiency in rats
    Rieko Mitamura
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita 9, Nishi 9, 060 8589 Sapporo, Japan
    Eur J Nutr 45:242-9. 2006
    ..Vitamin D (VD) and estrogen deficiencies impair Ca absorption and bone mineralization, and the relevance of the interaction between these factors has not been fully understood...
  58. doi request reprint Elimination of selected pharmaceuticals by biosolids from municipal wastewater treatment plants: importance of modest pH change and degree of mineralization
    K Kimura
    Division of Built Environment, Hokkaido University, Sapporo, Japan
    Water Sci Technol 62:1084-9. 2010
    ..e. gc/ms or lc/ms/ms)...
  59. ncbi request reprint Effects of ingestion of difructose anhydride III (DFA III) and the DFA III-assimilating bacterium Ruminococcus productus on rat intestine
    Kimiko Minamida
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Japan
    Biosci Biotechnol Biochem 70:332-9. 2006
    ..productus + DFA III-fed rats than in control or R. productus-fed rats. A combination of R. productus and DFA III might improve the balance of intestinal microbiota to a healthier condition...
  60. ncbi request reprint Casein binds to the cell membrane and induces intracellular calcium signals in the enteroendocrine cell: a brief communication
    Tohru Hira
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
    Exp Biol Med (Maywood) 228:850-4. 2003
    ..These results suggest that casein, a dietary protein, binds to a putative receptor on the CCK-producing enteroendocrine cell membrane and elicits the subsequent intracellular calcium response via an L-type calcium channel...
  61. ncbi request reprint Various non-digestible saccharides increase intracellular calcium ion concentration in rat small-intestinal enterocytes
    Takuya Suzuki
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Japan
    Br J Nutr 92:751-5. 2004
    ..Thus, molecular structure may be more important than the size of the NDS in the induction of Ca signalling in the cells...
  62. ncbi request reprint A soluble flavonoid-glycoside, alphaG-rutin, is absorbed as glycosides in the isolated gastric and intestinal mucosa
    Megumi Matsumoto
    Laboratory of Nutritional Biochemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    Biosci Biotechnol Biochem 68:1929-34. 2004
    ..The highest transport was shown in the ileal mucosa. These results indicate that alphaG-rutin is partly hydrolyzed to rutin through the intestine and absorbed as such...
  63. ncbi request reprint Ingestion of an indigestible saccharide, difructose anhydride III, partially prevents the tannic acid-induced suppression of iron absorption in rats
    Kaosar Afsana
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
    J Nutr 133:3553-60. 2003
    ..Our results demonstrate that TA reduces iron absorption and induces anemia, conditions that are partially prevented by the feeding of DFA III, but not FOS...
  64. doi request reprint Improved analysis of bile acids in tissues and intestinal contents of rats using LC/ESI-MS
    Masahito Hagio
    Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University, Sapporo, Hokkaido, Japan
    J Lipid Res 50:173-80. 2009
    ..Analyzing detailed BA profiles, including conjugation status, in a single run is possible using UPLC/ESI-MS. This method will be useful for investigating the roles of BA metabolism under physiological and pathological conditions...
  65. ncbi request reprint Various nondigestible saccharides open a paracellular calcium transport pathway with the induction of intracellular calcium signaling in human intestinal Caco-2 cells
    Takuya Suzuki
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    J Nutr 134:1935-41. 2004
    ..The 4 nondigestible saccharides increased net calcium transport in the cells via the paracellular route through tight junctions. The rise in [Ca(2+)](i) induced by these saccharides may be involved in the opening of tight junctions...
  66. ncbi request reprint Enteral administration of soybean phosphatidylcholine enhances the lymphatic absorption of lycopene, but reduces that of alpha-tocopherol in rats
    Megumi Nishimukai
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita 9, Nishi 9, Kita ku, Sapporo 060 8589, Japan
    J Nutr 134:1862-6. 2004
    ..The present results also show that the promotive effects of PC on lycopene absorption are influenced by the type of fatty acids in PC...
  67. ncbi request reprint Ingestion of water-soluble soybean fiber prevents osteopenia and hypercholesterolemia induced by ovariectomy in rats
    Rieko Mitamura
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita 9, Nishi 9, Kita ku, Sapporo 060 8589, Japan
    J Agric Food Chem 51:1085-9. 2003
    ..In conclusion, ingestion of WSSF prevented osteopenia and hypercholesterolemia induced by ovariectomy in rats...
  68. ncbi request reprint Ingestion of difructose anhydride III, a non-digestible disaccharide, improves postgastrectomy osteopenia in rats
    Kazuki Shiga
    Northern Advancement Center for Science and Technology, Colabo Hokkaido, Sapporo, Japan
    Scand J Gastroenterol 41:1165-73. 2006
    ..The potential of DFAIII to promote large intestinal calcium absorption was also evaluated through comparison with that of fructooligosaccharides (FOS)...
  69. ncbi request reprint Effects of difructose anhydride III (DFA III) administration on bile acids and growth of DFA III-assimilating bacterium Ruminococcus productus on rat intestine
    Kimiko Minamida
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita 9, Nishi 9, Kita ku, Sapporo, Hokkaido 060 8589, Japan
    J Biosci Bioeng 99:548-54. 2005
    ..The acidification of rat intestine perhaps inhibited secondary bile acid formation and decreased the ratio of secondary bile acids. Therefore, it is expected that DFA III may prevent colorectal cancer and be a new prebiotic candidate...
  70. ncbi request reprint Difructose anhydride III and sodium caprate activate paracellular transport via different intracellular events in Caco-2 cells
    Takuya Suzuki
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita 9, Nishi 9, Kita ku, Sapporo 060 8589, Japan
    Life Sci 79:401-10. 2006
    ..These data demonstrate that the increase in TJ permeability induced by DFAIII results from the alterations to actin and claudin-1 via [Ca(2+)](i)-independent mechanisms...
  71. ncbi request reprint Effects of long-term ingestion of difructose anhydride III (DFA III) on intestinal bacteria and bile acid metabolism in humans
    Kimiko Minamida
    Northern Advancement Center for Science and Technology, Nishi 12, Kita 21, Sapporo, Hokkaido 001 0021, Japan
    J Biosci Bioeng 101:149-56. 2006
    ..Moreover, as another cause for the decrease in the SBA ratio in total bile acids, it was suggested that the number of bile acid 7alpha-dehydroxylating bacteria were decreased by DFA III ingestion...
  72. doi request reprint The corn protein, zein hydrolysate, administered into the ileum attenuates hyperglycemia via its dual action on glucagon-like peptide-1 secretion and dipeptidyl peptidase-IV activity in rats
    Taisuke Mochida
    Division of Bio systems and Sustainability, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan 0608589
    Endocrinology 151:3095-104. 2010
    ....
  73. ncbi request reprint Effects of difructose anhydride III (DFA III) administration on rat intestinal microbiota
    Kimiko Minamida
    Northern Advancement Center for Science and Technology, Nishi 12, Kita 21, Kita ku, Sapporo, Hokkaido 001 0021, Japan
    J Biosci Bioeng 99:230-6. 2005
    ..Moreover, DFA III stimulated the growth of Ruminococcus sp. M-1 producing acetic acid, which may alter the intestinal microbiota towards a healthier composition. It is expected that DFA III would be a new candidate as a prebiotic...
  74. ncbi request reprint Ingestion of guar gum hydrolysate, a soluble and fermentable nondigestible saccharide, improves glucose intolerance and prevents hypertriglyceridemia in rats fed fructose
    Takuya Suzuki
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    J Nutr 134:1942-7. 2004
    ..Possible mediators of these beneficial effects of GGH are the SCFAs produced by microbial fermentation of GGH in the large intestine...
  75. doi request reprint Quercetin enhances intestinal barrier function through the assembly of zonula [corrected] occludens-2, occludin, and claudin-1 and the expression of claudin-4 in Caco-2 cells
    Takuya Suzuki
    Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University Kita 9, Nishi 9, Kita ku, Sapporo 060 8589, Japan
    J Nutr 139:965-74. 2009
    ..This study demonstrates that quercetin enhances the intestinal barrier function through the assembly of ZO-2, occludin, and claudin-1 by inhibiting PKCdelta and the increase in claudin-4 expression has an additional role after 12 h...
  76. ncbi request reprint Prolonged feeding of difructose anhydride III increases strength and mineral concentrations of the femur in ovariectomized rats
    Rieko Mitamura
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita 9, Nishi 9, Sapporo 060 8589, Japan
    Br J Nutr 94:268-74. 2005
    ..In conclusion, feeding of a low dose of DFAIII increased intestinal Ca and Mg absorption, and the promotive effect of DFAIII persisted for over 8 weeks. This effect was associated with prevention of ovariectomy-induced osteopenia...
  77. ncbi request reprint Strain and age-related changes in the localization of intestinal CD161+ natural killer cells and CD8+ intraepithelial lymphocytes along the longitudinal crypt axis in inbred rats
    Hong Xu
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    Biosci Biotechnol Biochem 69:567-74. 2005
    ....
  78. ncbi request reprint Adaptive changes in translation initiation activities for rat pancreatic protein synthesis with feeding of a high-protein diet
    Masaru Hashi
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
    J Nutr Biochem 16:507-12. 2005
    ....
  79. ncbi request reprint Voluntary running exercise alters microbiota composition and increases n-butyrate concentration in the rat cecum
    Megumi Matsumoto
    Laboratory of Nutritional Biochemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Hokkaido 060 8589, Japan
    Biosci Biotechnol Biochem 72:572-6. 2008
    ..This alteration of the cecal microbial environment may contribute to the beneficial effect of exercise on gastrointestinal disorders...
  80. ncbi request reprint The addition of soybean phosphatidylcholine to triglyceride increases suppressive effects on food intake and gastric emptying in rats
    Megumi Nishimukai
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
    J Nutr 133:1255-8. 2003
    ..These results demonstrate that oil containing lecithin inhibits gastric emptying and food intake, and the effects are associated in part with CCK release...
  81. ncbi request reprint Reducing effect of ingesting tannic acid on the absorption of iron, but not of zinc, copper and manganese by rats
    Kaosar Afsana
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    Biosci Biotechnol Biochem 68:584-92. 2004
    ..Our findings suggest that the usual intake of polyphenols is relatively safe, but that a high intake by supplementation or by dietary habit of tannin affects only the Fe level...
  82. ncbi request reprint Evidence suggesting that difructose anhydride III is an indigestible and low fermentable sugar during the early stages after ingestion in humans
    Akiko Tamura
    Central Research Laboratory, FANCL Co, Ltd 12 1 3 Kamishinano Totsuka ku, Yokohama 244 0806, Japan
    J Nutr Sci Vitaminol (Tokyo) 49:422-7. 2003
    ..The incidence of specific abdominal symptoms tended to be lower after DFAIII ingestion than after lactulose ingestion. It thus turned out that DFAIII was indigestible and low fermentable in the early stages after ingestion...
  83. ncbi request reprint Melibiose, difructose anhydride III and difructose anhydride IV enhance net calcium absorption in rat small and large intestinal epithelium by increasing the passage of tight junctions in vitro
    Hitoshi Mineo
    Northern Advancement Center for Scientific and Technology, Colabo Hokkaido, Sapporo 001 0021, Japan
    J Nutr 132:3394-9. 2002
    ..We concluded that the three indigestible saccharides directly affect the epithelial tissue and activate the passage of tight junctions, thereby promoting Ca absorption in the small and large intestine in vitro...
  84. ncbi request reprint Difructose anhydride III does not contribute to body energy accumulation in rats
    Akiko Tamura
    Research Institute, FANCL Co
    Biosci Biotechnol Biochem 70:1416-22. 2006
    ..DFAIII was not detected in feces, showing complete degradation of DFAIII in the intestine. These results indicate that DFAIII is a fermentable saccharide with quite low available energy for fat accumulation...
  85. ncbi request reprint Absorptive activity of calcium in the isolated cecal epithelium adaptively increased by 2 week's feeding of difructose anhydride III in rats
    Hitoshi Mineo
    Northern Advancement Center for Science and Technology, Colabo Hokkaido, Sapporo 001 0021, Japan
    Biosci Biotechnol Biochem 67:1847-51. 2003
    ..Ability of paracellular Ca passage via Tight-junction (TJ) in the cecum was changed adaptively by feeding of DFA III. Changes in microbial fermentation may affect the functional changes of Ca transport in cecal epithelium itself...
  86. ncbi request reprint Indigestible disaccharides open tight junctions and enhance net calcium, magnesium, and zinc absorption in isolated rat small and large intestinal epithelium
    Hitoshi Mineo
    Northern Advancement Center for Science and Technology, Colabo Hokkaido, Sapporo 001 0021, Japan
    Dig Dis Sci 49:122-32. 2004
    ..We concluded that the three indigestible saccharides directly affect the epithelial tissue and open TJs, thereby promoting Ca, Mg, and Zn absorption in the small and large intestine in vitro...
  87. ncbi request reprint Effect of difructose anhydride III on calcium absorption in humans
    Norihiro Shigematsu
    Food Research Division, Central Research Laboratory, FANCL Co, Ltd, Kanagawa Ken, Japan
    Biosci Biotechnol Biochem 68:1011-6. 2004
    ..These findings suggests that low dose of DFAIII had a stimulating effect on calcium absorption in humans...
  88. ncbi request reprint Supplementation of difructose anhydride III enhanced elevation of plasma equol concentrations and lowered plasma total cholesterol in isoflavone-fed rats
    Akiko Tamura
    Research Institute, FANCL Co, 12 13 Kamishinano Totsuka Ku, Yokohama 244 0806, Japan
    Br J Nutr 96:442-9. 2006
    ..Higher plasma equol concentrations may contribute to the hypocholesterolaemic effect of DFAIII feeding...
  89. ncbi request reprint Different effects of difructose anhydride III and inulin-type fructans on caecal microbiota in rats
    Akiko Tamura
    Research Institute, FANCL Co, Yokohama, Japan
    Arch Anim Nutr 60:358-64. 2006
    ..Results indicate that DFAIII has different effects on caecal microbiota compared to inulin and FOS and that these differences are most likely due to the alpha(3-->2) bonds in DFAIII...
  90. doi request reprint Low activities of intestinal lactase suppress the early phase absorption of soy isoflavones in Japanese adults
    Akiko Tamura
    Research Institute, FANCL Co, Yokohama, Japan
    Clin Nutr 27:248-53. 2008
    ..The contribution of lactase to isoflavone bioavailability has not been clarified. We evaluated the association between lactase activity and the bioavailability of isoflavone glucosides in Japanese adults...
  91. ncbi request reprint Ingestion of difructose anhydride III enhances absorption and retention of calcium in healthy men
    Kyoko Tomita
    Research Institute, FANCL Co, Kamishinano, Yokohama, Japan
    Biosci Biotechnol Biochem 71:681-7. 2007
    ..These results indicate that DFAIII ingestion enhances intestinal calcium absorption, which might be beneficial for bone metabolism...
  92. ncbi request reprint Peptides derived from dolicholin, a phaseolin-like protein in country beans (Dolichos lablab), potently stimulate cholecystokinin secretion from enteroendocrine STC-1 cells
    Md Kaosar Niaz Bin Sufian
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita 9, Nishi 9, Kita ku, Sapporo 060 8589, Japan
    J Agric Food Chem 55:8980-6. 2007
    ....
  93. ncbi request reprint Antigenicity and irritancy tests of leukocyte-reduction filters using animal models
    Akira Kokubunji
    Department of Transfusion Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Kobe J Med Sci 52:17-26. 2006
    ....
  94. ncbi request reprint Suppression of intestinal crypt cell proliferation and aberrant crypt foci by dietary quercetin in rats
    Jennifer M Gee
    Institute of Food Research Norwich Laboratory, Norwich Research Park, Colney, Norwich, Norfolk NR4 7UA, UK
    Nutr Cancer 43:193-201. 2002
    ..At low concentrations, dietary quercetin inhibits induction of aberrant crypts by a mechanism that does not involve increased crypt cell apoptosis...
  95. ncbi request reprint Difructose anhydride III promotes absorption of the soluble flavonoid alphaG-rutin in rats
    Megumi Matsumoto
    Department of Food Science and Human Nutrition, Faculty of Human Life Science, Fuji Women s University, Ishikari, Hokkaido 061 3204, Japan
    J Agric Food Chem 55:4202-8. 2007
    ..These results indicate that alphaG-rutin is absorbed as the intact form and that DFAIII stimulates its absorption in the small intestine...
  96. ncbi request reprint Immortalization of bone marrow-derived human mesenchymal stem cells by removable simian virus 40T antigen gene: analysis of the ability to support expansion of cord blood hematopoietic progenitor cells
    Keisuke Nishioka
    Division of Hematology Oncology, Department of Medicine, Hyogo College of Medicine, Hyogo 663 8501, Japan
    Int J Oncol 23:925-32. 2003
    ..This cell line may be of value for developing strategies for ex vivo expansion of human HPC...
  97. ncbi request reprint Comparative effect of repeated ingestion of difructose anhydride III and palatinose on the induction of gastrointestinal symptoms in humans
    Akiko Tamura
    Central Research Laboratory, FANCL Co, Ltd, Totsuka ku, Yokohama, Japan
    Biosci Biotechnol Biochem 68:1882-7. 2004
    ....
  98. ncbi request reprint Inhibitory effects of psyllium on rat mineral absorption were abolished by reduction of viscosity with partial hydrolysis
    Patchana Asvarujanon
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita 9, Nishi 9, Kita ku, Sapporo 060 8589, Japan
    Biosci Biotechnol Biochem 68:1737-42. 2004
    ..Cecal pH was reduced only in rats fed HD-HP in both normal and ovariectomized rats. These results indicate that reduction of psyllium viscosity tends to counter inhibitory effects on mineral absorption...
  99. doi request reprint Pediococcus pentosaceus NB-17 for probiotic use
    Benjamas Jonganurakkun
    Nisseibio Co, Ltd, 1 13 Megumino Kita 3 chome, Eniwa, Hokkaido 061 1374, Japan
    J Biosci Bioeng 106:69-73. 2008
    ..It was confirmed that the administered strain NB-17 remained alive in feces. These results suggest the possibility to use the P. pentosaceus NB-17 as functional foods...
  100. ncbi request reprint Ingestion of difructose anhydride III and voluntary running exercise independently increase femoral and tibial bone mineral density and bone strength with increasing calcium absorption in rats
    Kazuki Shiga
    Northern Advancement Center for Science and Technology, Colabo Hokkaido, Sapporo 001 0021, Japan
    J Nutr 133:4207-11. 2003
    ..We conclude that consuming DFAIII and running exercise additively enhance calcium absorption and differentially stimulate femoral and tibial BMD and mechanical properties in rats...