Satoshi Gando

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. ncbi request reprint Tissue factor production not balanced by tissue factor pathway inhibitor in sepsis promotes poor prognosis
    Satoshi Gando
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Crit Care Med 30:1729-34. 2002
  2. ncbi request reprint A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: comparing current criteria
    Satoshi Gando
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Crit Care Med 34:625-31. 2006
  3. doi request reprint Role of fibrinolysis in sepsis
    Satoshi Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Kita ku Sapporo, Japan
    Semin Thromb Hemost 39:392-9. 2013
  4. doi request reprint Differentiating disseminated intravascular coagulation (DIC) with the fibrinolytic phenotype from coagulopathy of trauma and acute coagulopathy of trauma-shock (COT/ACOTS)
    S Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Thromb Haemost 11:826-35. 2013
  5. doi request reprint The utility of a diagnostic scoring system for disseminated intravascular coagulation
    Satoshi Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Crit Care Clin 28:373-88, vi. 2012
  6. ncbi request reprint First day dynamic changes in antithrombin III activity after supplementation have a predictive value in critically ill patients
    Satoshi Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Am J Hematol 81:907-14. 2006
  7. ncbi request reprint An alternative pathway for fibrinolysis is activated in patients who have undergone cardiopulmonary bypass surgery and major abdominal surgery
    Satoshi Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, N17 W5, Sapporo 060, Japan
    Thromb Res 120:87-93. 2007
  8. ncbi request reprint High macrophage migration inhibitory factor levels in disseminated intravascular coagulation patients with systemic inflammation
    Satoshi Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, N15 W7, Kita ku, Sapporo 060, Japan
    Inflammation 30:118-24. 2007
  9. ncbi request reprint Systemic inflammation and disseminated intravascular coagulation in early stage of ALI and ARDS: role of neutrophil and endothelial activation
    Satoshi Gando
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Inflammation 28:237-44. 2004
  10. ncbi request reprint The activation of neutrophil elastase-mediated fibrinolysis is not sufficient to overcome the fibrinolytic shutdown of disseminated intravascular coagulation associated with systemic inflammation
    Satoshi Gando
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, N17 W5, Kita ku, Sapporo 060 Japan
    Thromb Res 121:67-73. 2007

Collaborators

Detail Information

Publications65

  1. ncbi request reprint Tissue factor production not balanced by tissue factor pathway inhibitor in sepsis promotes poor prognosis
    Satoshi Gando
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Crit Care Med 30:1729-34. 2002
    ....
  2. ncbi request reprint A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: comparing current criteria
    Satoshi Gando
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Crit Care Med 34:625-31. 2006
    ....
  3. doi request reprint Role of fibrinolysis in sepsis
    Satoshi Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Kita ku Sapporo, Japan
    Semin Thromb Hemost 39:392-9. 2013
    ....
  4. doi request reprint Differentiating disseminated intravascular coagulation (DIC) with the fibrinolytic phenotype from coagulopathy of trauma and acute coagulopathy of trauma-shock (COT/ACOTS)
    S Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Thromb Haemost 11:826-35. 2013
    ..However, available data suggest that COT/ACOTS is not a new concept but a disease entity similar to or the same as DIC with the fibrinolytic phenotype...
  5. doi request reprint The utility of a diagnostic scoring system for disseminated intravascular coagulation
    Satoshi Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Crit Care Clin 28:373-88, vi. 2012
    ..Because it is not easy to assess the superiority or inferiority of these scoring systems, it may be better to select the scoring system depending on the need for an early or affirmative diagnosis of DIC...
  6. ncbi request reprint First day dynamic changes in antithrombin III activity after supplementation have a predictive value in critically ill patients
    Satoshi Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Am J Hematol 81:907-14. 2006
    ..This dynamic change was associated with an improvement in the platelet counts, fibrinogen levels, and the DIC score...
  7. ncbi request reprint An alternative pathway for fibrinolysis is activated in patients who have undergone cardiopulmonary bypass surgery and major abdominal surgery
    Satoshi Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, N17 W5, Sapporo 060, Japan
    Thromb Res 120:87-93. 2007
    ....
  8. ncbi request reprint High macrophage migration inhibitory factor levels in disseminated intravascular coagulation patients with systemic inflammation
    Satoshi Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, N15 W7, Kita ku, Sapporo 060, Japan
    Inflammation 30:118-24. 2007
    ..MIF may therefore play a role in the inflammatory and thrombotic processes in DIC patients...
  9. ncbi request reprint Systemic inflammation and disseminated intravascular coagulation in early stage of ALI and ARDS: role of neutrophil and endothelial activation
    Satoshi Gando
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Inflammation 28:237-44. 2004
    ..The results also suggest that systemic activation of inflammation and coagulation associated with endothelial injury has prognostic value for the development of ARDS and poor outcome...
  10. ncbi request reprint The activation of neutrophil elastase-mediated fibrinolysis is not sufficient to overcome the fibrinolytic shutdown of disseminated intravascular coagulation associated with systemic inflammation
    Satoshi Gando
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, N17 W5, Kita ku, Sapporo 060 Japan
    Thromb Res 121:67-73. 2007
    ....
  11. ncbi request reprint Serial changes in neutrophil-endothelial activation markers during the course of sepsis associated with disseminated intravascular coagulation
    Satoshi Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, N15, W7, Kita ku, Sapporo 060 Japan
    Thromb Res 116:91-100. 2005
    ....
  12. ncbi request reprint Tissue factor in trauma and organ dysfunction
    Satoshi Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Semin Thromb Hemost 32:48-53. 2006
    ....
  13. ncbi request reprint Natural history of disseminated intravascular coagulation diagnosed based on the newly established diagnostic criteria for critically ill patients: results of a multicenter, prospective survey
    Satoshi Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, N17 W5, Kita ku, Sapporo 060 8638 Japan
    Crit Care Med 36:145-50. 2008
    ..To survey the natural history of disseminated intravascular coagulation (DIC) in patients diagnosed according to the Japanese Association for Acute Medicine (JAAM) DIC scoring system in a critical care setting...
  14. doi request reprint Disseminated intravascular coagulation (DIC) diagnosed based on the Japanese Association for Acute Medicine criteria is a dependent continuum to overt DIC in patients with sepsis
    Satoshi Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology, Hokkaido University Graduate School of Medicine, N17 W5, Kita ku, Sapporo 060 8638 Japan
    Thromb Res 123:715-8. 2009
    ....
  15. doi request reprint Trauma, shock, and disseminated intravascular coagulation: lessons from the classical literature
    Satoshi Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Ann Surg 254:10-9. 2011
    ..The administration of an antifibrinolytic agent (tranexamic acid) may reduce the risk of death in bleeding trauma patients associated with this type of DIC...
  16. doi request reprint Microvascular thrombosis and multiple organ dysfunction syndrome
    Satoshi Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Crit Care Med 38:S35-42. 2010
    ....
  17. ncbi request reprint Predicting the severity of systemic inflammatory response syndrome (SIRS)-associated coagulopathy with hemostatic molecular markers and vascular endothelial injury markers
    Toshiaki Iba
    Division Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine
    J Trauma 63:1093-8. 2007
    ..The purpose of this study is to assess the prognostic value of these markers in patients with SIRS-associated hypercoagulopathy...
  18. doi request reprint Massive amounts of tissue factor induce fibrinogenolysis without tissue hypoperfusion in rats
    Mineji Hayakawa
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Shock 39:514-9. 2013
    ..The decrease in the α2-plasmin inhibitor level and the significant increase in the plasmin level may be the two main factors underlying the pathogenesis of hyperfibrin(ogen)olysis after TF administration...
  19. ncbi request reprint Combined activation of coagulation and inflammation has an important role in multiple organ dysfunction and poor outcome after severe trauma
    Satoshi Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Thromb Haemost 88:943-9. 2002
    ..These results suggest a close relationship between inflammation and thrombosis in posttrauma DIC...
  20. ncbi request reprint Chronological expression of PAR isoforms in acute liver injury and its amelioration by PAR2 blockade in a rat model of sepsis
    Subrina Jesmin
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, N17 W5, Kita ku, Sapporo 060, Japan
    Thromb Haemost 96:830-8. 2006
    ....
  21. ncbi request reprint Differential expression, time course and distribution of four PARs in rats with endotoxin-induced acute lung injury
    Subrina Jesmin
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, N15 W7, Kita ku, Sapporo 060, Japan
    Inflammation 30:14-27. 2007
    ..The differential expression patterns (over a time course) and distribution of PAR isoforms suggests a distinct role for each isoform in the pathogenesis of LPS-induced ALI...
  22. doi request reprint Disseminated intravascular coagulation with a fibrinolytic phenotype at an early phase of trauma predicts mortality
    Atsushi Sawamura
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Japan
    Thromb Res 124:608-13. 2009
    ..To test the hypothesis that DIC with a fibrinolytic phenotype at an early stage of trauma also contributes to a poor outcome due to severe bleeding, we conducted a retrospective, cohort study...
  23. doi request reprint Normal prothrombinase activity, increased systemic thrombin activity, and lower antithrombin levels in patients with disseminated intravascular coagulation at an early phase of trauma: comparison with acute coagulopathy of trauma-shock
    Yuichiro Yanagida
    From the Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Surgery 154:48-57. 2013
    ....
  24. ncbi request reprint Temporal changes in pulmonary expression of key procoagulant molecules in rabbits with endotoxin-induced acute lung injury: elevated expression levels of protease-activated receptors
    Subrina Jesmin
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Thromb Haemost 92:966-79. 2004
    ..These results suggest that the increased expression levels of PARs, in addition to PAI-1 and TF, may, in part, underlie the development of ALI occurring during endotoxemia...
  25. doi request reprint Coagulofibrinolytic changes in patients with disseminated intravascular coagulation associated with post-cardiac arrest syndrome--fibrinolytic shutdown and insufficient activation of fibrinolysis lead to organ dysfunction
    Takeshi Wada
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Thromb Res 132:e64-9. 2013
    ....
  26. ncbi request reprint Imbalances between the levels of tissue factor and tissue factor pathway inhibitor in ARDS patients
    Satoshi Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, N15, W7, Kita ku, Sapporo, 060 Japan
    Thromb Res 109:119-24. 2003
    ....
  27. doi request reprint Disseminated intravascular coagulation (DIC) at an early phase of trauma continuously proceeds to DIC at a late phase of trauma
    Hiromoto Murakami
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Clin Appl Thromb Hemost 18:364-9. 2012
    ..Trauma itself, but not sepsis, contributes to the continuous progression of DIC from the early to late phase of trauma. The severity of DIC and organ dysfunction are involved in the pathogenesis of this continuous progression...
  28. ncbi request reprint Therapeutic effect of in vivo transfection of transcription factor decoy to NF-kappaB on septic lung in mice
    Naoyuki Matsuda
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Am J Physiol Lung Cell Mol Physiol 287:L1248-55. 2004
    ..Our results indicate for the first time the potential usefulness of NF-kappaB decoy ODN for gene therapy of endotoxic shock...
  29. doi request reprint Imbalance between macrophage migration inhibitory factor and cortisol induces multiple organ dysfunction in patients with blunt trauma
    Mineji Hayakawa
    Emergency and Critical Care Center, Hokkaido University Hospital, N14W5 Kita ku, Sapporo, 060 8648, Japan
    Inflammation 34:193-7. 2011
    ..An excessive serum MIF elevation overrides the anti-inflammatory effects of cortisol and leads to persistent SIRS followed by MODS in blunt trauma patients...
  30. doi request reprint Application of the Japanese Association for Acute Medicine disseminated intravascular coagulation diagnostic criteria for patients at an early phase of trauma
    Atsushi Sawamura
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, N17W5, Kita ku, Sapporo, 060 8638 Japan
    Thromb Res 124:706-10. 2009
    ....
  31. doi request reprint The response of antithrombin III activity after supplementation decreases in proportion to the severity of sepsis and liver dysfunction
    Mineji Hayakawa
    Emergency and Critical Care Center, Hokkaido University Hospital, Sapporo, Japan
    Shock 30:649-52. 2008
    ..These results suggest that the response to antithrombin III supplementation may be affected by both a systemic inflammation and impaired synthesis in patients with sepsis...
  32. doi request reprint Disseminated intravascular coagulation at an early phase of trauma is associated with consumption coagulopathy and excessive fibrinolysis both by plasmin and neutrophil elastase
    Mineji Hayakawa
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Surgery 149:221-30. 2011
    ..Furthermore, we hypothesized that disseminated intravascular coagulation at an early phase of trauma progresses dependently to disseminated intravascular coagulation with a thorombotic phenotype from 3 to 5 days after injury...
  33. ncbi request reprint Pharmacokinetics of teicoplanin in critically ill patients undergoing continuous hemodiafiltration
    Kazuaki Yagasaki
    Clinical Pharmaceutics and Therapeutics, Graduate School of Pharmaceutical Sciences, University of Hokkaido, N12, W6, Kita ku, 060 0812, Sapporo, Japan
    Intensive Care Med 29:2094-5. 2003
  34. doi request reprint A low TAFI activity and insufficient activation of fibrinolysis by both plasmin and neutrophil elastase promote organ dysfunction in disseminated intravascular coagulation associated with sepsis
    Mineji Hayakawa
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, N15W7, Kita ku, Sapporo 060 8638, Japan
    Thromb Res 130:906-13. 2012
    ....
  35. doi request reprint The dynamics of angiogenic factors and their soluble receptors in relation to organ dysfunction in disseminated intravascular coagulation associated with sepsis
    Subrina Jesmin
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, N15W7, Kita ku, Sapporo, 060 8638, Japan
    Inflammation 36:186-96. 2013
    ....
  36. ncbi request reprint Normalization by edaravone, a free radical scavenger, of irradiation-reduced endothelial nitric oxide synthase expression
    Xiao Hong Zhang
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    Eur J Pharmacol 476:131-7. 2003
    ..We thus assume that oxygen-free radicals may be closely related to the irradiation-induced derangement of the eNOS gene regulation...
  37. ncbi request reprint Insufficient production of urinary trypsin inhibitor for neutrophil elastase release after cardiac arrest
    Mineji Hayakawa
    Emergency and Critical Care Center, Hokkaido University Hospital, Sapporo, Japan
    Shock 29:549-52. 2008
    ....
  38. doi request reprint Effectiveness of end-expiratory lung volume measurements during the lung recruitment maneuver for patients with atelectasis
    Susumu Nakahashi
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, N15W7 Kita ku, Sapporo 060 8638, Japan
    J Crit Care 28:534.e1-5. 2013
    ..The aim of this study was to determine whether the relative change in the end-expiratory lung volume (EELV) obtained by the recruitment maneuver (RM) can serve as an indicator of the change in the P/F ratio...
  39. ncbi request reprint Contractions to histamine in pulmonary and mesenteric arteries from endotoxemic rabbits: modulation by vascular expressions of inducible nitric-oxide synthase and histamine H1-receptors
    Naoyuki Matsuda
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    J Pharmacol Exp Ther 307:175-81. 2003
    ..From these results, we propose that histamine may contribute to the development of endotoxin-induced pulmonary hypertension...
  40. doi request reprint Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome and disseminated intravascular coagulation patients
    Mineji Hayakawa
    Emergency and Critical Care Center, Hokkaido University Hospital, Sapporo, Japan
    Shock 33:14-8. 2010
    ..The length of ICU stay of the sivelestat group was significantly shorter than that of the control group. In addition, sivelestat administration was found to be an independent predictor of survival of those patients...
  41. ncbi request reprint Nuclear factor-kappaB decoy oligodeoxynucleotides prevent acute lung injury in mice with cecal ligation and puncture-induced sepsis
    Naoyuki Matsuda
    Department of Pharmacology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Mol Pharmacol 67:1018-25. 2005
    ..Our results suggest that ODN decoy, acting as in vivo competitor for the transcription factor's ability to bind to cognate recognition sequence, may represent an effective strategy in the treatment of septic acute lung injury...
  42. doi request reprint Effects of antithrombin III in patients with disseminated intravascular coagulation diagnosed by newly developed diagnostic criteria for critical illness
    Atsushi Sawamura
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Clin Appl Thromb Hemost 15:561-6. 2009
    ..The authors conclude that the effects of antithrombin on prognosis and coagulation and fibrinolytic parameters are independent of the doses administered in patients with SIRS/sepsis-associated DIC...
  43. ncbi request reprint Evaluation of new Japanese diagnostic criteria for disseminated intravascular coagulation in critically ill patients
    Satoshi Gando
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University, Graduate School of Medicine, Sapporo City, Japan
    Clin Appl Thromb Hemost 11:71-6. 2005
    ....
  44. ncbi request reprint Pharmacokinetics and the most suitable regimen of panipenem/beta mipron in critically ill patients receiving continuous renal replacement therapy: a pilot study
    Mineji Hayakawa
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Hokkaido University Graduate School of Pharmaceutical Sciences, Sapporo, Japan
    ASAIO J 52:398-403. 2006
    ..5 g every 12 hours or 1 g every 15 hoursPAPM CLtot 80 to 120 0.5 g every 8 hours or 1 g every 12 hoursPAPM CLtot 120 to 160 0.5 g every 6 hours or 1 g every 8 hours...
  45. ncbi request reprint Histamine H1 and H2 receptor gene and protein levels are differentially expressed in the hearts of rodents and humans
    Naoyuki Matsuda
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    J Pharmacol Exp Ther 309:786-95. 2004
    ....
  46. doi request reprint The administration of ciprofloxacin during continuous renal replacement therapy: pilot study
    Mineji Hayakawa
    Emergency and Critical Care Center, Hokkaido University Hospital, Sapporo, Hokkaido, Japan
    ASAIO J 55:243-5. 2009
    ..We confirmed that the CPFX concentrations reached higher than optimal concentrations, and infection was successfully controlled in these patients...
  47. ncbi request reprint The sympathomimetic actions of l-ephedrine and d-pseudoephedrine: direct receptor activation or norepinephrine release?
    Shigeaki Kobayashi
    Departments of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    Anesth Analg 97:1239-45. 2003
    ....
  48. pmc The role of angiogenic factors and their soluble receptors in acute lung injury (ALI)/ acute respiratory distress syndrome (ARDS) associated with critical illness
    Takeshi Wada
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, N17W5, Kita ku, Sapporo, Hokkaido, 060 8638, Japan
    J Inflamm (Lond) 10:6. 2013
    ..abstract:..
  49. ncbi request reprint A prospective comparative study of three sets of criteria for disseminated intravascular coagulation: ISTH criteria vs Japanese criteria
    Mineji Hayakawa
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Clin Appl Thromb Hemost 13:65-72. 2007
    ..However, the nonovert DIC criteria take more time to diagnose DIC than the Japanese criteria do. A more precise clinical study is needed to determined appropriate specific criteria and cutoff points in the nonovert DIC criteria set...
  50. doi request reprint Dramatic changes of the gut flora immediately after severe and sudden insults
    Mineji Hayakawa
    Emergency and Critical Care Center, Hokkaido University Hospital, N14W5 Kita ku, Sapporo, 060 8648, Japan
    Dig Dis Sci 56:2361-5. 2011
    ..The gut flora is crucially involved in host homeostasis. However, the changes in the gut flora during the early phase of a critical illness are unknown...
  51. ncbi request reprint Pharmacokinetics and the most suitable dosing regimen of fluconazole in critically ill patients receiving continuous hemodiafiltration
    Kazuaki Yagasaki
    Clinical Pharmaceutics and Therapeutics, Graduate School of Pharmaceutical Sciences Hokkaido University, N12, W6, Kita ku, 060 0812 Sapporo, Japan
    Intensive Care Med 29:1844-8. 2003
    ..To evaluate fluconazole pharmacokinetics and the dosage best suited to maintain effective plasma concentration in patients with continuous hemodiafiltration...
  52. ncbi request reprint [Coagulofibrinolytic response to surgical insult]
    Satoshi Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    Nihon Geka Gakkai Zasshi 104:840-6. 2003
    ..To prevent the progression of DIC, new drugs like activated protein C which can control both coagulation and inflammation now appear promising...
  53. pmc Using angiogenic factors and their soluble receptors to predict organ dysfunction in patients with disseminated intravascular coagulation associated with severe trauma
    Takeshi Wada
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, N17W5, Kita ku, Sapporo 060 8638, Japan
    Crit Care 16:R63. 2012
    ..The aim of the study was to assess the relationship between angiogenic factors, their soluble receptors and organ dysfunction associated with DIC after severe trauma...
  54. ncbi request reprint Synbiotic therapy reduces the pathological gram-negative rods caused by an increased acetic acid concentration in the gut
    Mineji Hayakawa
    Emergency and Critical Care Center, Hokkaido University Hospital, N14W5 Kita ku, Sapporo 060 8648, Japan
    Dig Dis Sci 57:2642-9. 2012
    ..The mechanisms for the improvement of the gut flora and the intestinal environment by synbiotic therapy are unclear...
  55. ncbi request reprint Hemodynamic significance of histamine synthesis and histamine H1- and H2-receptor gene expression during endotoxemia
    Naoyuki Matsuda
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    Naunyn Schmiedebergs Arch Pharmacol 366:513-21. 2002
    ..We suggest that overproduction of histamine may be partly responsible for the hemodynamic alterations of endotoxemia...
  56. ncbi request reprint A Prospective comparison of new Japanese criteria for disseminated intravascular coagulation: new Japanese criteria versus ISTH criteria
    Mineji Hayakawa
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, N15 W7, Sapporo 060 8638, Japan
    Clin Appl Thromb Hemost 13:172-81. 2007
    ..Furthermore, the new Japanese criteria provided the earliest detection and most accurate outcome prediction of DIC among the DIC criteria sets...
  57. doi request reprint Invasive group A streptococcal infection in pregnancy
    Takahiro Yamada
    Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, N15W7 Kita ku, Sapporo 060 8638, Japan
    J Infect 60:417-24. 2010
    ..Early use of antibiotics and intravenous immunoglobulin may improve outcome of pregnant women suffering from flu-like symptoms, shock and strong uterine contractions suggestive of placental abruption...
  58. doi request reprint Shortening of cardiopulmonary resuscitation time before the defibrillation worsens the outcome in out-of-hospital VF patients
    Mineji Hayakawa
    Emergency and Critical Care Center, Hokkaido University Hospital, Sapporo, Japan
    Am J Emerg Med 27:470-4. 2009
    ..The purpose of the study is to investigate the influence of cardiopulmonary resuscitation (CPR) time before the first defibrillation...
  59. doi request reprint IL-6 and IFN-alpha from dsRNA-stimulated dendritic cells control expansion of regulatory T cells
    Nobuhiko Kubota
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Biochem Biophys Res Commun 391:1421-6. 2010
    ..These data suggest that the balance of IL-6 and IFN-alpha in the region of RNA virus infection may determine the number of peripheral Treg, which affects the effective immune responses against viruses...
  60. doi request reprint Improved detection of heat stroke-induced brain injury by high b-value diffusion-weighted imaging
    Kentaro Kobayashi
    Department of Diagnostic Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Comput Assist Tomogr 35:498-500. 2011
    ..Routine DWI showed only mild hyperintensity of part of dentate lesions. High b-value DWI could be valuable for improved detection of heat stroke-induced brain injury...
  61. ncbi request reprint [Systemic inflammatory response syndrome (SIRS) and endothelial cell injury]
    Satoshi Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine
    Nihon Rinsho 62:2244-50. 2004
    ..Last we demonstrated an important role of inflammatory circulation disturbance induced by endothelial cell injury for the pathogenesis of MODS in SIRS and sepsis...
  62. ncbi request reprint [A case of brugada syndrome presenting with syncope transferred by ambulance to a neurosurgical hospital]
    Atsushi Sawamura
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Japan
    No Shinkei Geka 38:463-71. 2010
    ..Since, Brugada syndrome is a disease that may result in sudden death, further steps, such as an ICD (implantable cardioverter defibrillator) are thus considered to be necessary in this case...
  63. ncbi request reprint Evaluation of haemostatic molecular markers for diagnosis of disseminated intravascular coagulation in patients with infections
    Hidesaku Asakura
    Department of Laboratory Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu City, Mie 514 8507, Japan
    Thromb Haemost 95:282-7. 2006
    ..We conclude that hemostatic molecular markers might be useful for the diagnosis of DIC and should be confirmed by several trials...
  64. ncbi request reprint SIRS-associated coagulopathy and organ dysfunction in critically ill patients with thrombocytopenia
    Hiroshi Ogura
    Department of Traumatology and Acute Critical Medicine, Osaka University Medical School, Suita, Japan
    Shock 28:411-7. 2007
    ..Thus, we evaluated coagulative activity, organ dysfunction, and systemic inflammatory response syndrome (SIRS) in critically ill patients with thrombocytopenia and examined the balance between coagulopathy and systemic inflammation...
  65. ncbi request reprint Time-dependent expression of renal vaso-regulatory molecules in LPS-induced endotoxemia in rat
    Naoto Yamaguchi
    Center for Medical Sciences, Ibaraki Prefectural University of Health Sciences, Ibaraki 300 0394, Japan
    Peptides 27:2258-70. 2006
    ..These shifts in molecular expressions are likely triggered by compensatory mechanisms aimed at counteracting the undesirable and dominant effects of one group of vaso-regulatory moiety over the other...