S Gando

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. ncbi request reprint Imbalances between the levels of tissue factor and tissue factor pathway inhibitor in ARDS patients
    Satoshi Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, N15, W7, Kita ku, Sapporo, 060 Japan
    Thromb Res 109:119-24. 2003
  2. ncbi request reprint Macrophage migration inhibitory factor is a critical mediator of systemic inflammatory response syndrome
    S Gando
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    Intensive Care Med 27:1187-93. 2001
  3. ncbi request reprint Alterations of soluble L- and P-selectins during cardiac arrest and CPR
    S Gando
    Department of Anesthesiology and Intensive Care, Hokkaido University School of Medicine, Sapporo, Japan
    Intensive Care Med 25:588-93. 1999
  4. ncbi request reprint Systemic activation of tissue-factor dependent coagulation pathway in evolving acute respiratory distress syndrome in patients with trauma and sepsis
    S Gando
    Department of Anesthesiology and Intensive Care, Hokkaido University School of Medicine, Sapporo, Japan
    J Trauma 47:719-23. 1999
  5. ncbi request reprint Tissue factor and tissue factor pathway inhibitor levels during and after cardiopulmonary resuscitation
    S Gando
    Department of Anesthesiology and Intensive Care, Hokkaido University School of Medicine, Sapporo, Japan
    Thromb Res 96:107-13. 1999
  6. ncbi request reprint Disseminated intravascular coagulation in trauma patients
    S Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Semin Thromb Hemost 27:585-92. 2001
  7. ncbi request reprint Combined activation of coagulation and inflammation has an important role in multiple organ dysfunction and poor outcome after severe trauma
    Satoshi Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Thromb Haemost 88:943-9. 2002
  8. ncbi request reprint Out-of-hospital cardiac arrest increases soluble vascular endothelial adhesion molecules and neutrophil elastase associated with endothelial injury
    S Gando
    Department of Anesthesiology and Intensive Care, Hokkaido University School of Medicine, N15 W7, Kita ku, Sapporo, 060 Japan
    Intensive Care Med 26:38-44. 2000
  9. ncbi request reprint Tissue factor pathway inhibitor response does not correlate with tissue factor-induced disseminated intravascular coagulation and multiple organ dysfunction syndrome in trauma patients
    S Gando
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    Crit Care Med 29:262-6. 2001
  10. ncbi request reprint Cardiac profile of EGIS-9377, a novel cardiotonic agent as a Ca2+ sensitizer with bradycardiac activity
    Y Hattori
    Department of Pharmacology, Hokkaido University School of Medicine, Sapporo, Japan
    Naunyn Schmiedebergs Arch Pharmacol 360:585-90. 1999

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Imbalances between the levels of tissue factor and tissue factor pathway inhibitor in ARDS patients
    Satoshi Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, N15, W7, Kita ku, Sapporo, 060 Japan
    Thromb Res 109:119-24. 2003
    ....
  2. ncbi request reprint Macrophage migration inhibitory factor is a critical mediator of systemic inflammatory response syndrome
    S Gando
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    Intensive Care Med 27:1187-93. 2001
    ....
  3. ncbi request reprint Alterations of soluble L- and P-selectins during cardiac arrest and CPR
    S Gando
    Department of Anesthesiology and Intensive Care, Hokkaido University School of Medicine, Sapporo, Japan
    Intensive Care Med 25:588-93. 1999
    ....
  4. ncbi request reprint Systemic activation of tissue-factor dependent coagulation pathway in evolving acute respiratory distress syndrome in patients with trauma and sepsis
    S Gando
    Department of Anesthesiology and Intensive Care, Hokkaido University School of Medicine, Sapporo, Japan
    J Trauma 47:719-23. 1999
    ....
  5. ncbi request reprint Tissue factor and tissue factor pathway inhibitor levels during and after cardiopulmonary resuscitation
    S Gando
    Department of Anesthesiology and Intensive Care, Hokkaido University School of Medicine, Sapporo, Japan
    Thromb Res 96:107-13. 1999
    ..These results indicate the activation of the extrinsic coagulation pathway without adequate TFPI generation, which may contribute to thrombin activation and fibrin formation after whole-body ischemia and reperfusion...
  6. ncbi request reprint Disseminated intravascular coagulation in trauma patients
    S Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Semin Thromb Hemost 27:585-92. 2001
    ..DIC associated with sustained systemic inflammatory response syndrome (SIRS) after trauma leads to the development of MODS, which is the main determinant of patients' outcome after trauma...
  7. ncbi request reprint Combined activation of coagulation and inflammation has an important role in multiple organ dysfunction and poor outcome after severe trauma
    Satoshi Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Thromb Haemost 88:943-9. 2002
    ..These results suggest a close relationship between inflammation and thrombosis in posttrauma DIC...
  8. ncbi request reprint Out-of-hospital cardiac arrest increases soluble vascular endothelial adhesion molecules and neutrophil elastase associated with endothelial injury
    S Gando
    Department of Anesthesiology and Intensive Care, Hokkaido University School of Medicine, N15 W7, Kita ku, Sapporo, 060 Japan
    Intensive Care Med 26:38-44. 2000
    ..To investigate the inflammatory responses in patients with out-of-hospital cardiac arrest, we examined the changes in markers of endothelial activation, neutrophil activation, and endothelial injury...
  9. ncbi request reprint Tissue factor pathway inhibitor response does not correlate with tissue factor-induced disseminated intravascular coagulation and multiple organ dysfunction syndrome in trauma patients
    S Gando
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    Crit Care Med 29:262-6. 2001
    ..The DIC associated with thrombotic and inflammatory responses causes MODS, and leads to poor outcome in post-trauma patients...
  10. ncbi request reprint Cardiac profile of EGIS-9377, a novel cardiotonic agent as a Ca2+ sensitizer with bradycardiac activity
    Y Hattori
    Department of Pharmacology, Hokkaido University School of Medicine, Sapporo, Japan
    Naunyn Schmiedebergs Arch Pharmacol 360:585-90. 1999
    ..This cardiac profile of EGIS-9377 is suggested to be a clinically favorable feature compared with the inotropic agents having cyclic AMP generation or phosphodiesterase inhibition as their action mechanisms...
  11. ncbi request reprint Impaired contractile response to beta adrenoceptor stimulation in diabetic rat hearts: alterations in beta adrenoceptors-G protein-adenylate cyclase system and phospholamban phosphorylation
    S Gando
    Department of Pharmacology, Hokkaido University School of Medicine, Sapporo, Japan
    J Pharmacol Exp Ther 282:475-84. 1997
    ....
  12. ncbi request reprint Another point of view on the mechanism of thrombin generation during cardiopulmonary bypass: role of tissue factor pathway inhibitor
    T Kojima
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    J Cardiothorac Vasc Anesth 15:60-4. 2001
    ..These changes occur along with ongoing thrombin generation and its activation. Either insufficient prevention of thrombin generation by TFPI or indirect activation of the intrinsic coagulation pathway occurs during CPB...
  13. pmc Altered cardiac adrenergic neurotransmission in streptozotocin-induced diabetic rats
    S Gando
    Department of Pharmacology, Hokkaido University School of Medicine, Sapporo, Japan
    Br J Pharmacol 109:1276-81. 1993
    ..The present results also indicate that presynaptic alpha 2-adrenoceptors and muscarinic receptors that are linked to inhibition of the noradrenaline release during nerve stimulation may be functionally impaired in diabetic animals...
  14. pmc Diminished function and expression of the cardiac Na+-Ca2+ exchanger in diabetic rats: implication in Ca2+ overload
    Y Hattori
    Departments of Pharmacology and Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    J Physiol 527:85-94. 2000
    ..We suggest that this impaired NCX function may play an important role in alterations in Ca2+ handling when [Ca2+]i rises to pathological levels...
  15. ncbi request reprint Postoperative myocardial ischemia in thoracic aortic aneurysms
    S Sasaki
    Department of Cardiovascular Surgery, Hokkaido University Hospital, Sapporo, Japan
    J Cardiovasc Surg (Torino) 42:333-8. 2001
    ..To determine the incidence and predictors of postoperative myocardial ischemia in non-coronary risk patients undergoing surgery for thoracic aortic aneurysms...
  16. ncbi request reprint Systemic macrophage migration inhibitory factor release following hepatic resection
    S Gando
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    Surg Today 31:605-9. 2001
    ..Surgical stress may play a more important role in MIF secretion than inflammatory stimulus by TNF-alpha in these patients. Therefore, MIF minimally affects short-term postoperative morbidity and outcome...
  17. ncbi request reprint Serial measurement of arterial lactate concentrations as a prognostic indicator in relation to the incidence of disseminated intravascular coagulation in patients with systemic inflammatory response syndrome
    S Kobayashi
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    Surg Today 31:853-9. 2001
    ..DIC might play an important role in the pathogenesis of lactate production in these newly defined critically ill patients...
  18. ncbi request reprint Differential gene transcriptional regulation of Gi isoforms and Gs protein expression in diabetic rat hearts
    N Matsuda
    Department of Anesthesiology and Intensive Care, Hokkaido University School of Medicine, Sapporo, Japan
    Naunyn Schmiedebergs Arch Pharmacol 361:53-60. 2000
    ..The reduced expression of Gi-2alpha and Gi-3alpha proteins can be explained, at least in part, by the decreases in the transcriptional levels...
  19. ncbi request reprint Predictors of mortality in patients treated with continuous hemodiafiltration for acute renal failure in an intensive care setting
    S Sasaki
    Division of Intensive Care, Hokkaido University Hospital, Sapporo, Japan
    ASAIO J 47:86-91. 2001
    ..The cut-off value set at bilirubin levels > 10 mg/dl or arterial lactate levels > 3.5 mmol/L may serve as beneficial predictors of hospital mortality...
  20. ncbi request reprint The effect of calcium channel blockers on cerebral oxygenation during tracheal extubation
    Y Morimoto
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    Anesth Analg 91:347-52. 2000
    ..Cerebral oxygenated hemoglobin increased significantly, presumably caused by the increase in cerebral blood flow during extubation. In addition, these changes were enhanced by calcium channel blockers...
  21. ncbi request reprint Impairment of cardiac beta-adrenoceptor cellular signaling by decreased expression of G(s alpha) in septic rabbits
    N Matsuda
    Hokkaido University School of Medicine, Sapporo, Japan
    Anesthesiology 93:1465-73. 2000
    ..circulatory failure in patients with septic shock is known to be less responsive to catecholamines, we investigated whether the beta-adrenoceptor-linked signal transduction mechanisms are altered in the heart of a septic animal model..
  22. ncbi request reprint Pentobarbital inhibits apoptosis in neuronal cells
    Y Morimoto
    Department of Anesthesiology and Intensive Care, Hokkaido University School of Medicine, Central Research Institute, Sapporo, Japan
    Crit Care Med 28:1899-904. 2000
    ..Recently, it has been suggested that apoptosis is involved in ischemic neuronal death. This study examined the effect of pentobarbital on neuronal apoptosis...
  23. doi request reprint Differentiating disseminated intravascular coagulation (DIC) with the fibrinolytic phenotype from coagulopathy of trauma and acute coagulopathy of trauma-shock (COT/ACOTS)
    S Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Thromb Haemost 11:826-35. 2013
    ..However, available data suggest that COT/ACOTS is not a new concept but a disease entity similar to or the same as DIC with the fibrinolytic phenotype...
  24. ncbi request reprint Systematic elucidation of effects of tranexamic acid on fibrinolysis and bleeding during and after cardiopulmonary bypass surgery
    T Kojima
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Thromb Res 104:301-7. 2001
    ..While tranexamic acid had no effects on the other important fibrinolytic inhibitors like PAI-1 and alpha2-antiplasmin...
  25. ncbi request reprint Effects of Ca2+ sensitizers on contraction, [Ca2+]i transient and myofilament Ca2+ sensitivity in diabetic rat myocardium: potential usefulness as inotropic agents
    T Ishitani
    Department of Anesthesiology, and Critical Care Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    J Pharmacol Exp Ther 298:613-22. 2001
    ....
  26. ncbi request reprint Experimental Pseudomonas aeruginosa pneumonia: evaluation of the associated inflammatory response
    O Sibila
    Pneumology Service, Barcelona Hospital Clinic IDIBAPS, University of Barcelona, Spain
    Eur Respir J 30:1167-72. 2007
    ....