Toshiya Atsumi

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. ncbi request reprint Expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase/PFKFB3 isoforms in adipocytes and their potential role in glycolytic regulation
    Toshiya Atsumi
    Department of Medicine II, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Diabetes 54:3349-57. 2005
  2. ncbi request reprint Phosphorylation of the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase/PFKFB3 family of glycolytic regulators in human cancer
    Hidenori Bando
    Department of Medicine II, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Clin Cancer Res 11:5784-92. 2005
  3. ncbi request reprint Increased Fructose 2,6-bisphosphate in peripheral blood mononuclear cells of patients with diabetes
    Toshiya Atsumi
    Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo 060 0812, Japan
    Endocr J 54:517-20. 2007
  4. ncbi request reprint The potential role of macrophage migration inhibitory factor on the migration of vascular smooth muscle cells
    Toshiya Okamoto
    Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Atheroscler Thromb 15:13-9. 2008
  5. ncbi request reprint Clinical analysis of cognitive function in diabetic patients by MMSE and SPECT
    Hirokatsu Niwa
    Department of Internal Medicine II, Hokkaido University Graduate School of Medicine, North 15th, West 7th, Sapporo, Hokkaido 060 8638, Japan
    Diabetes Res Clin Pract 72:142-7. 2006
  6. ncbi request reprint A novel mutation of WFS1 gene in a Japanese man of Wolfram syndrome with positive diabetes-related antibodies
    Akinobu Nakamura
    Department of Medicine II, Hokkaido University Graduate School of Medicine, N 15, W 7, Kita ku, Sapporo 060 8638, Japan
    Diabetes Res Clin Pract 73:215-7. 2006
  7. ncbi request reprint The proinflammatory cytokine macrophage migration inhibitory factor regulates glucose metabolism during systemic inflammation
    Toshiya Atsumi
    Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    J Immunol 179:5399-406. 2007
  8. ncbi request reprint High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers
    Toshiya Atsumi
    The Picower Institute for Medical Research NY, Manhasset, New York 10030, USA
    Cancer Res 62:5881-7. 2002
  9. doi request reprint Low-dose aspirin for primary prevention of atherosclerotic events in patients with type 2 diabetes: a randomized controlled trial
    Hisao Ogawa
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto City, 860 8556, Japan
    JAMA 300:2134-41. 2008

Collaborators

  • JASON A CHESNEY
  • Takao Koike
  • Hirokatsu Niwa
  • Yuri Ono
  • Eun Gyoung Hong
  • Shin Onodera
  • Robert A Mitchell
  • M Shimabukuro
  • Masao Kanauchi
  • Jason K Kim
  • Chikara Shimizu
  • Narihito Yoshioka
  • Toshiya Okamoto
  • Hisao Ogawa
  • Akinobu Nakamura
  • Hidenori Bando
  • Yoshiharu Nishitani
  • Kenichi Yamaga
  • Eri Miyake
  • Kenji Obata
  • Syuichi Kamijikkoku
  • Seiji Ozawa
  • Akira Matsutani
  • Hiroto Okubo
  • Masakuni Uemyama
  • Isao Yasuda
  • Shinya Yumoto
  • Shojiro Naomi
  • Yoshiaki Osamura
  • Yutaka Ishibashi
  • Fumishi Tomita
  • Shiro Uemura
  • Tomohiro Sawada
  • Kiyotaka Kudou
  • Takeshi Matsuo
  • Koichi Hoda
  • Junji Shibata
  • Shigeru Yamano
  • Takafumi Odo
  • Ken Iwai
  • Kazuo Goto
  • Hironori Hasegawa
  • Masamitsu Toihata
  • Hideaki Jinnouchi
  • Masafumi Nakayama
  • Tsuneo Ikeda
  • Shinya Okamoto
  • Makiko Ohtorii
  • Yoshihisa Iseri
  • Eiji Oshima
  • Takeshi Morimoto
  • Toshiaki Nasu
  • Takeshi Koga
  • Genshi Egusa
  • Kazuo Nishimoto
  • Yukitaka Nakano
  • Hiroyuki Shono
  • Yoshimi Kinoshita
  • Syuichi Matsuo
  • Keizo Kajiwara
  • Hironori Murakami
  • Motomu Hayashi
  • Kenichi Komori
  • Kozaburo Matsuyama
  • Tamio Nakajima
  • Akiko Yasuno
  • Ryo Fukami
  • Mayumi Kiyota
  • Toshio Sutani
  • Yutaka Horio
  • Osamu Doi
  • Kazuko Horii
  • Yoshihiko Saito
  • Etsuo Kinuwaki
  • Kazuo Kozuma
  • Hirofumi Ogata
  • Eiji Kawashima
  • Yuya Tanaka
  • Yoshihiro Kimura
  • Michiaki Ueda
  • Kenji Onoue
  • Kimiaki Miwa
  • Hisaharu Makino
  • Akira Nakatani
  • Tatsuaki Tsuchiya
  • Sueo Momosaki
  • Makoto Ikemura
  • Kazuo Kimura
  • Hirofumi Kan
  • Kiyotaka Sughihara

Detail Information

Publications9

  1. ncbi request reprint Expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase/PFKFB3 isoforms in adipocytes and their potential role in glycolytic regulation
    Toshiya Atsumi
    Department of Medicine II, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Diabetes 54:3349-57. 2005
    ..These data expand the role of these structurally unique iPFK-2/PFKFB3 isoforms in the metabolic regulation of adipocytes...
  2. ncbi request reprint Phosphorylation of the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase/PFKFB3 family of glycolytic regulators in human cancer
    Hidenori Bando
    Department of Medicine II, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Clin Cancer Res 11:5784-92. 2005
    ..PFKFB3 protein is expressed in high levels in human tumors in situ. The purpose of this study was to determine the role of functional interactions between the phosphorylation of PFKFB3 and activated glycolysis in human cancer cells...
  3. ncbi request reprint Increased Fructose 2,6-bisphosphate in peripheral blood mononuclear cells of patients with diabetes
    Toshiya Atsumi
    Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo 060 0812, Japan
    Endocr J 54:517-20. 2007
    ..These data suggest that hyperglycemia increases intracellular F2,6BP in immune cells. These findings may help to clarify the impaired function in immune cells in patients with diabetes...
  4. ncbi request reprint The potential role of macrophage migration inhibitory factor on the migration of vascular smooth muscle cells
    Toshiya Okamoto
    Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Atheroscler Thromb 15:13-9. 2008
    ..However, the functional role of MIF in VSMCs has not been elucidated. The aim of this study was to investigate the role of MIF on the migration of VSMCs...
  5. ncbi request reprint Clinical analysis of cognitive function in diabetic patients by MMSE and SPECT
    Hirokatsu Niwa
    Department of Internal Medicine II, Hokkaido University Graduate School of Medicine, North 15th, West 7th, Sapporo, Hokkaido 060 8638, Japan
    Diabetes Res Clin Pract 72:142-7. 2006
    ..The incidence of cognitive functional impairment in elderly, diabetic patients was significantly elevated and was accompanied by a reduction in cerebral blood flow in the fronto-temporal region, as determined by SPECT...
  6. ncbi request reprint A novel mutation of WFS1 gene in a Japanese man of Wolfram syndrome with positive diabetes-related antibodies
    Akinobu Nakamura
    Department of Medicine II, Hokkaido University Graduate School of Medicine, N 15, W 7, Kita ku, Sapporo 060 8638, Japan
    Diabetes Res Clin Pract 73:215-7. 2006
    ..Genetic analysis revealed that WFS1 gene of the patient has a homozygous 5 base pairs (AAGGC) insertion at position 1279 in exon 8, causing a frameshift at codon 371 leading to premature termination at codon 443...
  7. ncbi request reprint The proinflammatory cytokine macrophage migration inhibitory factor regulates glucose metabolism during systemic inflammation
    Toshiya Atsumi
    Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    J Immunol 179:5399-406. 2007
    ..Genetic MIF deficiency also promotes adipogenesis, which is in accord with a downstream role for MIF in the action of TNF-alpha. These studies support an important role for MIF in host glucose metabolism during sepsis...
  8. ncbi request reprint High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers
    Toshiya Atsumi
    The Picower Institute for Medical Research NY, Manhasset, New York 10030, USA
    Cancer Res 62:5881-7. 2002
    ..These data indicate that iPFK-2 is abundantly expressed in human tumors in situ and may serve as an essential regulator of glycolysis during cell cycle progression and growth in an hypoxic microenvironment...
  9. doi request reprint Low-dose aspirin for primary prevention of atherosclerotic events in patients with type 2 diabetes: a randomized controlled trial
    Hisao Ogawa
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto City, 860 8556, Japan
    JAMA 300:2134-41. 2008
    ..Previous trials have investigated the effects of low-dose aspirin on primary prevention of cardiovascular events, but not in patients with type 2 diabetes...