Tatsuya Atsumi

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. ncbi request reprint Genetics of antiphospholipid syndrome
    T Atsumi
    Department of Medicine II, Hokkaido University School of Medicine, Sapporo, Japan
    Rheum Dis Clin North Am 27:565-72, vi. 2001
  2. doi request reprint Antiprothrombin antibody: why do we need more assays?
    T Atsumi
    Department of Medicine, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Lupus 19:436-9. 2010
  3. doi request reprint Exchange of information in rheumatology between east and west: from Man'yo-shu to the future
    Tatsuya Atsumi
    Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Arthritis Rheum 58:S140-2. 2008
  4. ncbi request reprint Antiprothrombin antibodies--are they worth assaying?
    Tatsuya Atsumi
    Department of Medicine II, Hokkaido University Graduate School of Medicine, N15 W7, Kita ku, Sapporo 060 8638, Japan
    Thromb Res 114:533-8. 2004
  5. ncbi request reprint Antiphospholipid antibody associated thrombocytopenia and the paradoxical risk of thrombosis
    T Atsumi
    Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Lupus 14:499-504. 2005
  6. ncbi request reprint Research around beta 2-glycoprotein I: a major target for antiphospholipid antibodies
    Tatsuya Atsumi
    Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Autoimmunity 38:377-81. 2005
  7. doi request reprint The effects of phosphatidylserine-dependent antiprothrombin antibody on thrombin generation
    Yoshie Sakai
    Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Arthritis Rheum 60:2457-67. 2009
  8. doi request reprint Efficacy of the antiphospholipid score for the diagnosis of antiphospholipid syndrome and its predictive value for thrombotic events
    Kotaro Otomo
    Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Arthritis Rheum 64:504-12. 2012
  9. doi request reprint Increased expression of phospholipid scramblase 1 in monocytes from patients with systemic lupus erythematosus
    Eriko Suzuki
    Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Rheumatol 37:1639-45. 2010
  10. doi request reprint Phospholipid scramblase 1 expression is enhanced in patients with antiphospholipid syndrome
    Olga Amengual
    Department of Medicine II, Hokkaido University Graduate School of Medicine, N15 W7, Kita ku, Sapporo, 060 8638, Japan
    Mod Rheumatol 23:81-8. 2013

Collaborators

Detail Information

Publications74

  1. ncbi request reprint Genetics of antiphospholipid syndrome
    T Atsumi
    Department of Medicine II, Hokkaido University School of Medicine, Sapporo, Japan
    Rheum Dis Clin North Am 27:565-72, vi. 2001
    ..Many other thrombosis-related genetic factors have been investigated in APS, but no additional risk for thrombosis has been indicated in patients with antiphospholipid antibodies...
  2. doi request reprint Antiprothrombin antibody: why do we need more assays?
    T Atsumi
    Department of Medicine, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Lupus 19:436-9. 2010
    ..Therefore, aPS/PT should be further explored, not only for research purposes, but also as a candidate for one of the enzyme-linked immunosorbent assay (ELISA)-based confirmatory test for APS associated LA...
  3. doi request reprint Exchange of information in rheumatology between east and west: from Man'yo-shu to the future
    Tatsuya Atsumi
    Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Arthritis Rheum 58:S140-2. 2008
  4. ncbi request reprint Antiprothrombin antibodies--are they worth assaying?
    Tatsuya Atsumi
    Department of Medicine II, Hokkaido University Graduate School of Medicine, N15 W7, Kita ku, Sapporo 060 8638, Japan
    Thromb Res 114:533-8. 2004
    ....
  5. ncbi request reprint Antiphospholipid antibody associated thrombocytopenia and the paradoxical risk of thrombosis
    T Atsumi
    Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Lupus 14:499-504. 2005
    ..More attention should be devoted to this subgroup of patients to elucidate the role of aPL in the development of thrombocytopenia and to facilitate the adequate monitoring of its potential thrombotic risk...
  6. ncbi request reprint Research around beta 2-glycoprotein I: a major target for antiphospholipid antibodies
    Tatsuya Atsumi
    Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Autoimmunity 38:377-81. 2005
    ..Recently, increasing attention is focused on the role of nicked-beta2GPI as a regulator of extrinsic fibrinolysis pathway...
  7. doi request reprint The effects of phosphatidylserine-dependent antiprothrombin antibody on thrombin generation
    Yoshie Sakai
    Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Arthritis Rheum 60:2457-67. 2009
    ..The purpose of this study was to investigate the effects of anti-PS/PT on thrombin generation and to examine the LAC paradox...
  8. doi request reprint Efficacy of the antiphospholipid score for the diagnosis of antiphospholipid syndrome and its predictive value for thrombotic events
    Kotaro Otomo
    Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Arthritis Rheum 64:504-12. 2012
    ..To define the antiphospholipid score (aPL-S) by testing multiple antiphospholipid antibodies (aPL) and to evaluate its efficacy for the diagnosis of antiphospholipid syndrome (APS) and predictive value for thrombosis...
  9. doi request reprint Increased expression of phospholipid scramblase 1 in monocytes from patients with systemic lupus erythematosus
    Eriko Suzuki
    Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Rheumatol 37:1639-45. 2010
    ..We investigated the underlying pathogenic status of thrombophilia in SLE by analyzing PLSCR1 expression on monocytes from patients with SLE...
  10. doi request reprint Phospholipid scramblase 1 expression is enhanced in patients with antiphospholipid syndrome
    Olga Amengual
    Department of Medicine II, Hokkaido University Graduate School of Medicine, N15 W7, Kita ku, Sapporo, 060 8638, Japan
    Mod Rheumatol 23:81-8. 2013
    ..One of the molecules involved in PS externalization is phospholipid scramblase 1 (PLSCR1). We evaluated PLSCR1 expression on monocytes from APS patients and analyzed the in vitro effect of monoclonal aPL on PLSCR1 expression...
  11. ncbi request reprint Antigenic structures recognized by anti-beta2-glycoprotein I auto-antibodies
    Hideki Kasahara
    Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Int Immunol 17:1533-42. 2005
    ..Thus, epitopic structures recognized by anti-beta2-GPI auto-antibodies are cryptic and inter-domain electrostatic interactions are involved in their in exposure...
  12. ncbi request reprint Beta2-glycoprotein I, anti-beta2-glycoprotein I, and fibrinolysis
    Shinsuke Yasuda
    Department of Medicine II, Hokkaido University Graduate School of Medicine, N15 W7, Kita ku, Sapporo 060 8638, Japan
    Thromb Res 114:461-5. 2004
    ..Thus, nicked beta2GPI plays a role in the extrinsic fibrinolysis via a negative feedback pathway loop...
  13. ncbi request reprint Pathogenesis of antiphospholipid antibodies: impairment of fibrinolysis and monocyte activation via the p38 mitogen-activated protein kinase pathway
    Shinsuke Yasuda
    Department of Medicine II, Hokkaido University School of Medicine, N 15 W 7, Kita ku, Sapporo 060 8648, Japan
    Immunobiology 210:775-80. 2005
    ..Thus, aCL/beta(2)GPI plays dual roles in the pathogenesis of APS, firstly by deranging the fibrinolytic system and secondly by activating monocytes, endothelial cells and thrombocytes to produce TF or thromboxane...
  14. ncbi request reprint Significance of valine/leucine247 polymorphism of beta2-glycoprotein I in antiphospholipid syndrome: increased reactivity of anti-beta2-glycoprotein I autoantibodies to the valine247 beta2-glycoprotein I variant
    Shinsuke Yasuda
    Medicine II, Hokkaido University Graduate School of Medicine, N15 W7, Kita ku, Sapporo 060 8638, Japan
    Arthritis Rheum 52:212-8. 2005
    ..The reactivity of anti-beta(2)GPI antibodies was characterized using recombinant Val(247) and Leu(247) beta(2)GPI...
  15. doi request reprint Hepatitis B virus reactivation by immunosuppressive therapy in patients with autoimmune diseases: risk analysis in Hepatitis B surface antigen-negative cases
    Masaru Kato
    Department of Medicine II, Hokkaido University Graduate School of Medicine, N15W7 Kita ku, Sapporo 060 8638, Japan
    J Rheumatol 38:2209-14. 2011
    ..To evaluate the risk of reactivation of resolved hepatitis B virus (HBV) by immunosuppressive therapy in patients with autoimmune diseases...
  16. ncbi request reprint Defective expression of Ras guanyl nucleotide-releasing protein 1 in a subset of patients with systemic lupus erythematosus
    Shinsuke Yasuda
    Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Immunol 179:4890-900. 2007
    ....
  17. doi request reprint Radiographic prognosis of finger joint damage predicted by early alteration in synovial vascularity in patients with rheumatoid arthritis: Potential utility of power doppler sonography in clinical practice
    Jun Fukae
    Hokkaido Medical Center for Rheumatic Diseases, Sapporo, Japan
    Arthritis Care Res (Hoboken) 63:1247-53. 2011
    ....
  18. ncbi request reprint Antiphospholipid antibodies: lessons from the bench
    Takao Koike
    Department of Medicine II, Hokkaido University Graduate School of Medicine, N15 W7, Kita ku, Sapporo 060 8638, Japan
    J Autoimmun 28:129-33. 2007
    ..Numerous mechanisms have been proposed to explain the thrombotic tendency of patients with aPL, but the pathogenesis seems to be multifactorial...
  19. ncbi request reprint Butyrate suppresses tumor necrosis factor alpha production by regulating specific messenger RNA degradation mediated through a cis-acting AU-rich element
    Jun Fukae
    Hokkaido University Graduate School of Medicine, Nishi, Sapporo, Japan
    Arthritis Rheum 52:2697-707. 2005
    ..7 macrophages...
  20. ncbi request reprint Nicked beta2-glycoprotein I: a marker of cerebral infarct and a novel role in the negative feedback pathway of extrinsic fibrinolysis
    Shinsuke Yasuda
    Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Blood 103:3766-72. 2004
    ..Intact beta(2)-GPI lacks these properties. These data suggest that beta(2)-GPI/plasmin-nicked beta(2)-GPI controls extrinsic fibrinolysis via a negative feedback pathway loop...
  21. ncbi request reprint [Antiphospholipid syndrome]
    Tatsuya Atsumi
    Department of Medicine II, Hokkaido University Graduate School of Medicine
    Nihon Rinsho 63:484-9. 2005
  22. doi request reprint Immunological reconstitution after autologous hematopoietic stem cell transplantation in patients with systemic sclerosis: relationship between clinical benefits and intensity of immunosuppression
    Toshiyuki Bohgaki
    Department of Medicine II, Hokkaido University Graduate School of Medicine, N15, W7, Kita ku, Sapporo 060 8638, Japan
    J Rheumatol 36:1240-8. 2009
    ..To analyze the relationship between clinical benefits and immunological changes in patients with systemic sclerosis (SSc) treated with autologous hematopoietic stem cell transplantation (HSCT)...
  23. doi request reprint Monitoring anti-interleukin 6 receptor antibody treatment for rheumatoid arthritis by quantitative magnetic resonance imaging of the hand and power Doppler ultrasonography of the finger
    Tamotsu Kamishima
    Department of Radiology, Hokkaido University Hospital, N15 W7, Kita ku, Sapporo, 0600815, Japan
    Skeletal Radiol 40:745-55. 2011
    ....
  24. ncbi request reprint Up-regulated expression of HLA-DRB5 transcripts and high frequency of the HLA-DRB5*01:05 allele in scleroderma patients with interstitial lung disease
    Toshio Odani
    Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Rheumatology (Oxford) 51:1765-74. 2012
    ..Interstitial lung disease (ILD) is a serious complication of SSc. We aimed to identify markers associated with SSc-related ILD...
  25. ncbi request reprint [Impaired expression of Act1mRNA in B cells of patients with Sjögren's syndrome]
    Yasuko Nakagawa
    Department of Medicine II, Hokkaido University Graduate School of Medicine
    Nihon Rinsho Meneki Gakkai Kaishi 35:75-80. 2012
    ..Diminished Act1mRNA expression in SS may be associated with B cell hyperactivity and elevated immunoglobulin production in SS by uncontrolled B cell activation signal through CD40 and BAFFR...
  26. doi request reprint Plasma gelsolin facilitates interaction between β2 glycoprotein I and α5β1 integrin
    Miyuki Bohgaki
    Department of Biochemistry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Cell Mol Med 15:141-51. 2011
    ....
  27. doi request reprint Nicked {beta}2-glycoprotein I binds angiostatin 4.5 (plasminogen kringle 1-5) and attenuates its antiangiogenic property
    Hisako Nakagawa
    Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Blood 114:2553-9. 2009
    ..5. Our data suggest that plasmin-nicked beta2GPI promotes angiogenesis by interacting with plasmin-generated AS4.5 in sites of increased fibrinolysis such as thrombus...
  28. ncbi request reprint Diagnostic value of antiagalactosyl IgG antibodies in rheumatoid arthritis
    Hemlata Das
    Department of Medicine II, Hokkaido University Graduate School of Medicine, N15 W7, Kitaku, 060 8638 Sapporo, Japan
    Clin Rheumatol 23:218-22. 2004
    ..Antiagalactosyl IgG antibodies are more specific markers for RA than conventional LN-RF, and may provide useful information for the diagnosis of RA...
  29. ncbi request reprint Antiprothombin antibodies and the diagnosis of antiphospholipid syndrome
    Olga Amengual
    Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Clin Immunol 112:144-9. 2004
    ..The latter, phosphatidylserine-dependent antiprothrombin antibodies (aPT), have been closely associated with APS and LA. In this paper, we review the properties of antiprothrombin antibodies...
  30. ncbi request reprint The p38 mitogen-activated protein kinase (MAPK) pathway mediates induction of the tissue factor gene in monocytes stimulated with human monoclonal anti-beta2Glycoprotein I antibodies
    Miyuki Bohgaki
    Department of Medicine II, Hokkaido University Graduate School of Medicine, N 15 W 7, Kita ku, Sapporo 060 8648, Japan
    Int Immunol 16:1633-41. 2004
    ....
  31. pmc Aberrant splicing of the hRasGRP4 transcript and decreased levels of this signaling protein in the peripheral blood mononuclear cells in a subset of patients with rheumatoid arthritis
    Toko Hashimoto
    Department of Medicine II, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo, 060 8638, Japan
    Arthritis Res Ther 13:R154. 2011
    ..The aim of our study was to identify the cells in human blood that express hRasGRP4, and then to determine if hRasGRP4 was altered in any patient with rheumatoid arthritis (RA)...
  32. doi request reprint Clinical features of reversible posterior leukoencephalopathy syndrome in patients with systemic lupus erythematosus
    Yuichiro Fujieda
    Department of Medicine II, Hokkaido University Graduate School of Medicine, N15W7, Kita ku, Sapporo 060 8638, Hokkaido, Japan
    Mod Rheumatol 21:276-81. 2011
    ..When 7-day therapy for hypertension and convulsion does not reverse the manifestations, immunosuppressive treatments would be recommended to reverse RPLS...
  33. ncbi request reprint A polymorphism in human platelet antigen 6b and risk of thrombocytopenia in patients with systemic lupus erythematosus
    Olga Amengual
    Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Arthritis Rheum 56:2803-5. 2007
  34. ncbi request reprint Clinical relevance of antiprothrombin antibodies
    Tatsuya Atsumi
    Department of Medicine II, Hokkaido University School of Medicine, N15 W7, Kita ku, Sapporo 060 8638, Japan
    Autoimmun Rev 1:49-53. 2002
    ..The determination of aPS/PT in routine clinical practice should be done in conjunction with other aPLs detection to improve the likelihood of recognising the APS, which would ultimately facilitate the management of the disease...
  35. doi request reprint Antiprothrombin antibody testing: detection and clinical utility
    Kenji Oku
    Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Semin Thromb Hemost 34:335-9. 2008
    ..aCL and aPS/PT have similar diagnostic value for APS, therefore aPS/PT should be further explored, not only for research purposes but also as a candidate for one of the laboratory criteria for the classification of the APS...
  36. doi request reprint Pathophysiology of thrombosis and pregnancy morbidity in the antiphospholipid syndrome
    Kenji Oku
    Department of Internal Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Eur J Clin Invest 42:1126-35. 2012
    ....
  37. doi request reprint Change of synovial vascularity in a single finger joint assessed by power doppler sonography correlated with radiographic change in rheumatoid arthritis: comparative study of a novel quantitative score with a semiquantitative score
    Jun Fukae
    Tokeidai Memorial Hospital, Sapporo, Japan
    Arthritis Care Res (Hoboken) 62:657-63. 2010
    ..To investigate the relationship between synovial vascularity assessed by quantitative power Doppler sonography (PDS) and progression of structural bone damage in a single finger joint in patients with rheumatoid arthritis (RA)...
  38. ncbi request reprint Pathophysiology of thrombosis and potential targeted therapies in antiphospholipid syndrome
    Olga Amengual
    Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Curr Vasc Pharmacol 9:606-18. 2011
    ..In this article, we review the pathophysiological mechanisms of thrombosis and the specific new targeted therapies for the treatment in APS...
  39. ncbi request reprint Polymyalgia rheumatica as the manifestation of unclassified aortitis
    Hiroshi Kataoka
    Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Mod Rheumatol 18:105-8. 2008
    ..It should be acknowledged that aortitis might present as PMR and imaging studies are recommended...
  40. ncbi request reprint Specificities, properties, and clinical significance of antiprothrombin antibodies
    Olga Amengual
    Hokkaido University School of Medicine, Sapporo, Japan
    Arthritis Rheum 48:886-95. 2003
  41. ncbi request reprint [Immunological and serological tests for diagnosis of rheumatoid arthritis: anti-agalactosyl IgG antibody]
    Tatsuya Atsumi
    Department of Medicine II, Hokkaido University Graduate School of Medicine
    Nihon Rinsho 63:328-31. 2005
  42. ncbi request reprint Suppressed intrinsic fibrinolytic activity by monoclonal anti-beta-2 glycoprotein I autoantibodies: possible mechanism for thrombosis in patients with antiphospholipid syndrome
    Rie Takeuchi
    Department of Medicine II, Hokkaido University School of Medicine, Kita ku, Sapporo, Japan
    Br J Haematol 119:781-8. 2002
    ..This suppression was not only due to inhibition of factor XII activation but was also related to function of activated factor XII (XIIa). These phenomena partly explain the mechanisms of thrombosis in APS...
  43. ncbi request reprint Gene polymorphisms of tissue plasminogen activator and plasminogen activator inhibitor-1 in patients with antiphospholipid antibodies
    Shinsuke Yasuda
    Department of Medicine II, Hokkaido University School of Medicine, Sapporo, Japan
    J Rheumatol 29:1192-7. 2002
    ..We investigated the consequences of the gene polymorphisms of tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) in patients positive for aPL...
  44. doi request reprint Overexpression of TNF-α-converting enzyme in fibroblasts augments dermal fibrosis after inflammation
    Shinji Fukaya
    Department of Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Lab Invest 93:72-80. 2013
    ..These results also suggest that TACE and EGFR on fibroblasts may be novel therapeutic targets of dermal fibrosis, which is induced after diverse inflammatory disorders of the skin...
  45. ncbi request reprint [Infliximab]
    Nobuya Yoshida
    Department of Medicine II, Hokkaido University Graduate School of Medicine
    Nihon Rinsho 65:1251-8. 2007
    ..The data showed that 91.6% of patients had overall efficacy as "marked improvement" or "improvement". Serious adverse reaction was reported in 6.2%. Therefore, IFX is very effective and well tolerated in Japanese patients with RA...
  46. doi request reprint Antiphospholipid antibodies increase the risk of pregnancy-induced hypertension and adverse pregnancy outcomes
    Hideto Yamada
    Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Kita ku N15 W7, Sapporo 060 8638, Japan
    J Reprod Immunol 79:188-95. 2009
    ..7-66.7) or IgG aPE plus LA (22.2, 5.4-909) measurements predicted severe PIH with 30.8% sensitivity and 99.2% specificity. We conclude that aPL measurements during early pregnancy may be useful in predicting adverse pregnancy outcome...
  47. ncbi request reprint Human monoclonal antibodies against the complex of phosphatidylserine and prothrombin from patients with the antiphospholipid antibodies
    T Horita
    Department of Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan
    Lupus 16:509-16. 2007
    ....
  48. ncbi request reprint Significance of magnetic resonance imaging in the diagnosis of nodular regenerative hyperplasia of the liver complicated with systemic lupus erythematosus: a case report and review of the literature
    T Horita
    Department of Medicine II, Hokkaido University School of Medicine, Sapporo, Japan
    Lupus 11:193-6. 2002
    ..We reviewed the literature regarding NRH in SLE and discuss the management of the affected patients...
  49. ncbi request reprint Epitopes on beta2-GPI recognized by anticardiolipin antibodies
    T Koike
    Department of Medicine II, Hokkaido University School of Medicine, Sapporo, Japan
    Lupus 7:S14-7. 1998
    ..We used phage-displayed random peptide libraries to search the epitopes of human aCL. Structures similar to consensus sequences selected by a biopanning method was found on domain IV of beta2-GPI...
  50. ncbi request reprint [Antiphospholipid antibody associated thrombocytopenia]
    Shin Furukawa
    Department of Medicine II, Hokkaido University Graduate School of Medicine
    Nihon Rinsho Meneki Gakkai Kaishi 26:267-73. 2003
  51. doi request reprint Contrast-enhanced whole-body joint MRI in patients with unclassified arthritis who develop early rheumatoid arthritis within 2 years: feasibility study and correlation with MRI findings of the hands
    Tamotsu Kamishima
    Department of Radiology, Hokkaido University Hospital, Kita ku, Sapporo City, Hokkaido 0600815, Japan
    AJR Am J Roentgenol 195:W287-92. 2010
    ....
  52. ncbi request reprint A woman with infectious endocarditis caused by Abiotrophia defectiva
    Toko Hashimoto
    Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo
    Intern Med 43:1000-4. 2004
    ..Infectious diseases caused by Abiotrophia defectiva are extremely rare, and identification of this pathogen is important, as its bacterial characteristics require proper attention...
  53. doi request reprint Autoimmune disease after autologous hematopoietic stem cell transplantation
    Toshiyuki Bohgaki
    Department of Medicine II, Hokkaido University Graduate School of Medicine N 15 W 7, Kita ku, Sapporo 060 8638, Japan
    Autoimmun Rev 7:198-203. 2008
    ..Although the mechanism of autoimmunity after HSCT is not well-known, long-term follow-up is essential in patients with autoimmune diseases treated with autologous HSCT...
  54. ncbi request reprint Anti-phosphatidylserine/prothrombin antibodies are not frequently found in patients with unexplained recurrent miscarriages
    A Tsutsumi
    Department of Medicine II, Hokkaido University School of Medicine, Sapporo, Japan
    Am J Reprod Immunol 46:242-4. 2001
    ..To determine whether the presence of anti-phosphatidylserine/ prothrombin antibodies (anti-PS/PT) can be a major factor in otherwise unexplained recurrent miscarriages...
  55. pmc Prediction of response to treatment by gene expression profiling of peripheral blood in patients with microscopic polyangiitis
    Akihiro Ishizu
    Faculty of Health Sciences, Hokkaido University, Sapporo, Japan
    PLoS ONE 8:e63182. 2013
    ....
  56. ncbi request reprint Thrombotic microangiopathy in patients with phosphatidylserine dependent antiprothrombin antibodies and antiphospholipid syndrome
    Y Kon
    Department of Medicine II, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Clin Exp Rheumatol 26:129-32. 2008
    ..Both patients were successfully treated with a series of plasma exchange...
  57. ncbi request reprint The significance of antiphospholipid antibodies tests
    Kotaro Otomo
    Department of Medicine II, Hokkaido University Graduate School of Medicine
    Nihon Rinsho Meneki Gakkai Kaishi 36:63-70. 2013
    ....
  58. ncbi request reprint Uveitis, pancarditis, haemophagocytosis, and abdominal masses
    Yoshie Sakai
    Department of Medicine II, Hokkaido University School of Medicine, N15 W7, Kita ku, 060 8638, Sapporo, Japan
    Lancet 361:834. 2003
  59. pmc Up regulated expression of tumour necrosis factor {alpha} converting enzyme in peripheral monocytes of patients with early systemic sclerosis
    T Bohgaki
    Department of Medicine II, Hokkaido University Graduate School of Medicine, Address N 15 W 7, Kita ku, Sapporo 060 8638, Japan
    Ann Rheum Dis 64:1165-73. 2005
    ..Systemic sclerosis (SSc) is accompanied by abnormalities in humoral and cellular immune systems...
  60. doi request reprint Clinical features of haemophagocytic syndrome in patients with systemic autoimmune diseases: analysis of 30 cases
    S Fukaya
    Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Rheumatology (Oxford) 47:1686-91. 2008
    ..Haemophagocytic syndrome (HPS) is known as a relatively rare complication in autoimmune diseases. Here we analysed the clinical features of HPS in patients with systemic autoimmune diseases...
  61. doi request reprint Complement activation in patients with primary antiphospholipid syndrome
    K Oku
    Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Ann Rheum Dis 68:1030-5. 2009
    ..To investigate the significance of complement activation in patients with primary antiphospholipid syndrome (APS)...
  62. ncbi request reprint [Phosphatidylserine-dependent anti-prothrombin antibody as a new marker for the diagnosis of antiphospholipid syndrome]
    Masahiro Ieko
    Department of Internal Medicine, School of Dentistry, Health Sciences University of Hokkaido, Ishikari gun, Hokkaido 061 0293
    Rinsho Byori 54:256-62. 2006
    ..The determination of aPS/PT in clinical practice, in conjunction with that of other aPL, may improve the likelihood of recognizing APS...
  63. ncbi request reprint Antiprothrombin antibodies detected in two different assay systems. Prevalence and clinical significance in systemic lupus erythematosus
    Maria Laura Bertolaccini
    Lupus Research Unit, The Rayne Institute, St Thomas Hospital, London SE1 7EH, UK
    Thromb Haemost 93:289-97. 2005
    ..Their presence is associated with thrombosis, making these antibodies potential markers for the APS. Testing for these antibodies could be of clinical benefit in patients who are negative for the routinely used tests...
  64. ncbi request reprint "Resurrection of thrombin" in the pathophysiology of the antiphospholipid syndrome
    Takao Koike
    Arthritis Rheum 56:393-4. 2007
  65. ncbi request reprint [Clinical significance of antiphospholipid antibody in diagnosis of collagen diseases]
    Tatsuya Atsumi
    Nihon Naika Gakkai Zasshi 96:2138-43. 2007
  66. ncbi request reprint Multiple autoimmune diseases after autologous stem-cell transplantation
    Toshiyuki Bohgaki
    N Engl J Med 357:2734-6. 2007
  67. ncbi request reprint Anti-beta(2)-glycoprotein I antibodies in children with atopic dermatitis
    Ales Ambrozic
    Department of Rheumatology, University Medical Centre, Vodnikova 62, 1000 Ljubljana, Slovenia
    Int Immunol 14:823-30. 2002
    ..The epitopic difference from anti-beta(2)GPI in APS may explain presumed non-thrombogenicity of anti-beta(2)GPI in children with AD...
  68. ncbi request reprint Circulating oxidized LDL forms complexes with beta2-glycoprotein I: implication as an atherogenic autoantigen
    Kazuko Kobayashi
    Department of Cell Chemistry, Okayama University Graduate School of Medicine and Dentistry, Japan
    J Lipid Res 44:716-26. 2003
    ..Further, these same Abs correlated with IgG immune complexes containing beta2-GPI or LDL. Thus, the beta2-GPI-oxLDL complexes acting as an autoantigen are closely associated with autoimmune-mediated atherogenesis...
  69. ncbi request reprint [Clinical significance of antiphospholipid antibody analysis in diagnosis of collagen diseases]
    Tatsuya Atsumi
    Nihon Naika Gakkai Zasshi 92:1948-55. 2003
  70. ncbi request reprint Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus
    Na Li
    Second Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan
    Hum Mol Genet 13:171-9. 2004
    ..Our findings suggest that these polymorphic LTKs cause up-regulation of the PI3K pathway and possibly form one genetic component of susceptibility to abnormal proliferation of self-reactive B cells in SLE...
  71. ncbi request reprint Vertebral fracture and bone mineral density in women receiving high dose glucocorticoids for treatment of autoimmune diseases
    Shunichi Kumagai
    Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
    J Rheumatol 32:863-9. 2005
    ..To evaluate the factors influencing the occurrence of vertebral fracture in patients receiving high dose glucocorticoids (GC)...
  72. ncbi request reprint Phosphatidylserine-dependent antiprothrombin antibodies are not useful markers for high-risk women with recurrent miscarriages
    Mayumi Sugiura-Ogasawara
    Department of Obstetrics and Gynecology, Nagoya City Medical School, Nagoya, Japan
    Fertil Steril 82:1440-2. 2004
    ..Because patients with aPS/PT were included in the 17 with LA, we should not add aPS/PT measurement to routine testing in addition to conventional aPL for patients with recurrent miscarriage...
  73. ncbi request reprint [Antiphospholipid syndrome: new criteria and management of the patients]
    Tatsuya Atsumi
    Ryumachi 43:528-37. 2003
  74. ncbi request reprint Prevalence of diverse antiphospholipid antibodies in women with recurrent spontaneous abortion
    Hideto Yamada
    Fertil Steril 80:1276-8. 2003