H Ariga

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. ncbi request reprint Induction of reactive oxygen species by bisphenol A and abrogation of bisphenol A-induced cell injury by DJ-1
    Hiromasa Ooe
    Graduate School of Pharmaceutical Sciences, Graduate School of Agriculture, Hokkaido University, Sapporo 060 0812, Japan
    Toxicol Sci 88:114-26. 2005
  2. pmc Neuroprotective function of DJ-1 in Parkinson's disease
    Hiroyoshi Ariga
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita ku, Sapporo 060 0812, Japan
    Oxid Med Cell Longev 2013:683920. 2013
  3. pmc Neuroprotective effect of a new DJ-1-binding compound against neurodegeneration in Parkinson's disease and stroke model rats
    Yoshihisa Kitamura
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Mol Neurodegener 6:48. 2011
  4. ncbi request reprint PAP-1, a novel target protein of phosphorylation by pim-1 kinase
    H Maita
    Department of Molecular Biology, Hokkaido University, Kita ku, Sapporo, Japan
    Eur J Biochem 267:5168-78. 2000
  5. ncbi request reprint MM-1, a c-Myc-binding protein, is a candidate for a tumor suppressor in leukemia/lymphoma and tongue cancer
    Y Fujioka
    Graduate School of Pharmaceutical Sciences, Department of Pathology, Graduate School of Medicine, College of Medical Technology, Hokkaido University, Kita ku, Sapporo 060 8012, Japan
    J Biol Chem 276:45137-44. 2001
  6. ncbi request reprint Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter
    T Taira
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo 060 0812, Japan
    Gene 263:285-92. 2001
  7. ncbi request reprint TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase
    T Ono
    Graduate School of Pharmaceutical Sciences, College of Medical Technology, Hokkaido University, Kita ku, Sapporo 060, Japan
    J Biol Chem 275:31145-54. 2000
  8. ncbi request reprint AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase
    M Furusawa
    Graduate School of Pharmaceutical Sciences, College of Medical Technology, Hokkaido University, Kita ku, Sapporo, Japan
    J Biol Chem 276:36647-51. 2001
  9. ncbi request reprint CDC6 interacts with c-Myc to inhibit E-box-dependent transcription by abrogating c-Myc/Max complex
    M Takayama
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita ku, Sapporo, Japan
    FEBS Lett 477:43-8. 2000
  10. ncbi request reprint Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1)
    N Koike
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo, Japan
    FEBS Lett 467:17-21. 2000

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Induction of reactive oxygen species by bisphenol A and abrogation of bisphenol A-induced cell injury by DJ-1
    Hiromasa Ooe
    Graduate School of Pharmaceutical Sciences, Graduate School of Agriculture, Hokkaido University, Sapporo 060 0812, Japan
    Toxicol Sci 88:114-26. 2005
    ..DJ-1 was found to maintain the complex I activity against BPA-induced oxidative stress after the localization in mitochondria. The results showed that DJ-1 plays a role in the prevention of mitochondrial injury-induced cell death...
  2. pmc Neuroprotective function of DJ-1 in Parkinson's disease
    Hiroyoshi Ariga
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita ku, Sapporo 060 0812, Japan
    Oxid Med Cell Longev 2013:683920. 2013
    ..DJ-1 is also a stress sensor and its expression is increased upon various stresses, including oxidative stress. In this review, we describe functions of DJ-1 against oxidative stress and possible roles of DJ-1 in the pathogenesis of PD...
  3. pmc Neuroprotective effect of a new DJ-1-binding compound against neurodegeneration in Parkinson's disease and stroke model rats
    Yoshihisa Kitamura
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Mol Neurodegener 6:48. 2011
    ..abstract:..
  4. ncbi request reprint PAP-1, a novel target protein of phosphorylation by pim-1 kinase
    H Maita
    Department of Molecular Biology, Hokkaido University, Kita ku, Sapporo, Japan
    Eur J Biochem 267:5168-78. 2000
    ..The two serine residues of PAP-1 at amino acids 204 and 206 near the C-terminus were phosphorylated by Pim-1. PAP-1 is thus thought to be a target protein for Pim-1 kinase...
  5. ncbi request reprint MM-1, a c-Myc-binding protein, is a candidate for a tumor suppressor in leukemia/lymphoma and tongue cancer
    Y Fujioka
    Graduate School of Pharmaceutical Sciences, Department of Pathology, Graduate School of Medicine, College of Medical Technology, Hokkaido University, Kita ku, Sapporo 060 8012, Japan
    J Biol Chem 276:45137-44. 2001
    ..The results suggest that MM-1 is a novel candidate for a tumor suppressor that controls the transcriptional activity of c-Myc...
  6. ncbi request reprint Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter
    T Taira
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo 060 0812, Japan
    Gene 263:285-92. 2001
    ....
  7. ncbi request reprint TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase
    T Ono
    Graduate School of Pharmaceutical Sciences, College of Medical Technology, Hokkaido University, Kita ku, Sapporo 060, Japan
    J Biol Chem 275:31145-54. 2000
    ..Furthermore, the results of three different types of experiments showed that TOK-1alpha enhanced the inhibitory activity of p21 toward histone H1 kinase activity of CDK2. TOK-1alpha is thus thought to be a new type of CDK2 modulator...
  8. ncbi request reprint AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase
    M Furusawa
    Graduate School of Pharmaceutical Sciences, College of Medical Technology, Hokkaido University, Kita ku, Sapporo, Japan
    J Biol Chem 276:36647-51. 2001
    ..These results suggest that AMY-1 plays a role in spermatogenesis...
  9. ncbi request reprint CDC6 interacts with c-Myc to inhibit E-box-dependent transcription by abrogating c-Myc/Max complex
    M Takayama
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita ku, Sapporo, Japan
    FEBS Lett 477:43-8. 2000
    ..In consequence, the E-box-dependent transcription activity of c-Myc was abrogated. These results suggest that, in addition to its DNA replication activity, CDC6 also has a role as a transcriptional suppressor of c-Myc...
  10. ncbi request reprint Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1)
    N Koike
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo, Japan
    FEBS Lett 467:17-21. 2000
    ..These results suggest that Pim-1 affects the structure or silencing of chromatin by phosphorylating HP1...
  11. ncbi request reprint Identification and cDNA cloning of single-stranded DNA binding proteins that interact with the region upstream of the human c-myc gene
    Y Negishi
    Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Oncogene 9:1133-43. 1994
    ..Binding properties of MSSP-1 imply its functions in DNA replication. Furthermore, when the AT stretch in the SV40 ori core was substituted by TCTTAT, MSSP-1 promoted viral DNA replication depending on the consensus sequences...
  12. ncbi request reprint Cell cycle-dependent switch of up-and down-regulation of human hsp70 gene expression by interaction between c-Myc and CBF/NF-Y
    T Taira
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita ku, Sapporo 060, Japan
    J Biol Chem 274:24270-9. 1999
    ..The results indicate that the cell cycle-dependent expression of the hsp70 gene is regulated by the intracellular amount of c-Myc through the complex formation states between CBF/NF-Y and c-Myc...
  13. ncbi request reprint AMY-1, a novel C-MYC binding protein that stimulates transcription activity of C-MYC
    T Taira
    Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita ku, Sapporo 060 Japan
    Genes Cells 3:549-65. 1998
    ..The N-terminal region is involved in all the biological functions of C-MYC, and different proteins are therefore thought to interact with the N-terminal region of C-MYC to display different functions...
  14. ncbi request reprint Primary structure, genomic organization and expression of the major secretory protein of murine epididymis, ME1
    Y Nakamura
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Gene 251:55-62. 2000
    ..The reduction of the molecular mass of the recombinant ME1 protein with the digestion of glycopeptidase A indicated that it is modified by Asn-linked glycosylation...
  15. ncbi request reprint A novel transrepression pathway of c-Myc. Recruitment of a transcriptional corepressor complex to c-Myc by MM-1, a c-Myc-binding protein
    A Satou
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo 060, Japan
    J Biol Chem 276:46562-7. 2001
    ..Moreover, the inhibitory activity of MM-1 toward c-Myc was canceled by trichostatin A, an inhibitor of HDAC1. These results indicate that MM-1 is a connecting factor that forms a novel transcription repression pathway of c-Myc...
  16. ncbi request reprint Diversity of sites for measles virus binding and for inactivation of complement C3b and C4b on membrane cofactor protein CD46
    K Iwata
    Division of Hygienic Chemistry, Hokkaido University, Sapporo, Japan
    J Biol Chem 270:15148-52. 1995
    ..The functional domains of MCP for the three natural ligands C3b, C4b, and MV, therefore, map to different, although partly overlapping, SCR domains...
  17. ncbi request reprint Pim-1 translocates sorting nexin 6/TRAF4-associated factor 2 from cytoplasm to nucleus
    Y Ishibashi
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    FEBS Lett 506:33-8. 2001
    ....
  18. ncbi request reprint Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities
    Y Shinbo
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Cell Death Differ 13:96-108. 2006
    ..Both L166P-expressing cells and DJ-1-knockdown cells were found to be highly susceptible to UV-induced cell apoptosis...
  19. ncbi request reprint DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras
    D Nagakubo
    Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Biochem Biophys Res Commun 231:509-13. 1997
    ..Moreover, DJ-1 translocated from cytoplasm to nuclei in the S phase of the cell cycle. DJ-1 is thus suggested to be a novel mitogen-dependent oncogene product involved in a Ras-related signal transduction pathway...
  20. ncbi request reprint Reciprocal regulation via protein-protein interaction between c-Myc and p21(cip1/waf1/sdi1) in DNA replication and transcription
    H Kitaura
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita ku, Sapporo 060 0812, Japan
    J Biol Chem 275:10477-83. 2000
    ..The balance of the reciprocal inactivation between c-Myc and p21 may determine the course of cellular processes such as cell proliferation, differentiation, and apoptosis...
  21. ncbi request reprint Effect of tenascin-X together with vascular endothelial growth factor A on cell proliferation in cultured embryonic hearts
    T Ikuta
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Biol Pharm Bull 24:1320-3. 2001
    ..5 fold compared with that in TNX-/- mice, indicating that TNX with VEGF family member plays an important role in the control of endothelial cell proliferation in vivo...
  22. ncbi request reprint Extracellular matrix tenascin-X in combination with vascular endothelial growth factor B enhances endothelial cell proliferation
    T Ikuta
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Genes Cells 5:913-927. 2000
    ..The precise in vivo role of TNX remains to be elucidated. To identify proteins that interact with TNX in the extracellular environment, we searched for TNX-binding proteins using a yeast two-hybrid system...
  23. ncbi request reprint MM-1, a novel c-Myc-associating protein that represses transcriptional activity of c-Myc
    K Mori
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita ku, Sapporo 060, Japan
    J Biol Chem 273:29794-800. 1998
    ..Furthermore, MM-1 repressed the activation of E-box-dependent transcription by c-Myc...
  24. ncbi request reprint Structures and comparison of genomic and complementary DNAs of mouse MSSP, a c-Myc binding protein
    M Fujimoto
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita ku, Sapporo 060 0812, Japan
    Int J Oncol 16:245-51. 2000
    ..Then, the genomic DNA of mouse MSSP was cloned. Mouse genomic MSSP gene was comprised of at least 13 exons over the region spanning 60 kb. Furthermore, a chromosome location of human MSSP gene was identified at 2q24 by FISH mapping...
  25. ncbi request reprint Disruption of MSSP, c-myc single-strand binding protein, leads to embryonic lethality in some homozygous mice
    M Fujimoto
    Graduate School of Pharmaceutical Sciences, College of Medical Technology, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo 060, Japan
    Genes Cells 6:1067-75. 2001
    ..These proteins possess two copies of putative RNA binding domains, RNP-A and RNP-B, and these RNA binding domains have been suggested to be indispensable to the functions of MSSP...
  26. ncbi request reprint MSSP, a protein binding to an origin of replication in the c-myc gene, interacts with a catalytic subunit of DNA polymerase alpha and stimulates its polymerase activity
    T Niki
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita ku, Sapporo, Japan
    FEBS Lett 475:209-12. 2000
    ..Furthermore, MSSP was released from the putative DNA replication origin of the c-myc gene after it complexed with DNA polymerase alpha, and MSSP stimulated DNA polymerase activity in vitro...
  27. ncbi request reprint Tumour invasion and metastasis are promoted in mice deficient in tenascin-X
    K Matsumoto
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Genes Cells 6:1101-11. 2001
    ..To determine whether TNX plays a part in tumour invasion and metastasis and to disclose its normal physiological role, we disrupted its gene in mouse embryonic stem cells by homologous recombination and created mice deficient in TNX...
  28. pmc Molecular cloning of MSSP-2, a c-myc gene single-strand binding protein: characterization of binding specificity and DNA replication activity
    T Takai
    Faculty of Pharmaceutical Sciences, Hokkaido University, Japan
    Nucleic Acids Res 22:5576-81. 1994
    ..MSSP-2 stimulated the DNA replication of an SV40-derived plasmid containing the binding sequence for MSSP-1 or -2. MSSP-2 is hence suggested to play an important role in regulation of DNA replication...
  29. pmc Cloning and characterization of the genomic DNA of the human MSSP genes
    C Haigermoser
    Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Nucleic Acids Res 24:3846-57. 1996
    ..Furthermore, it can be concluded that the MSSP gene 2 encodes both MSSP-1 and MSSP-2, and moreover scr2 and human YC1...
  30. ncbi request reprint Identification of novel single-stranded DNA binding proteins recognizing octamer motif
    N Ogawa
    Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Biochem Biophys Res Commun 200:1307-12. 1994
    ..Three proteins of 35, 60, and 125 KDa recognized the sequences. The proteins, which were not recognized by an anti-Oct-1 antibody, may be involved in regulation of the initiation of DNA replication in the IgH gene...
  31. ncbi request reprint Structural analysis of mouse tenascin-X: evolutionary aspects of reduplication of FNIII repeats in the tenascin gene family
    T Ikuta
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido 060 0812, Japan
    Gene 217:1-13. 1998
    ..We also analyzed the evolution of FNIII repeats in TNX...
  32. ncbi request reprint Involvement of PIM-1 in DNA fragmentation in mouse NS-1-derived cells
    C Takahashi
    Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Biochem Biophys Res Commun 215:538-46. 1995
    ..The results hence suggested that Pim-1 activates endonucleases responsible for DNA fragmentation during apoptosis and/or repress DNA repair systems to restore fragmented DNA...
  33. doi request reprint Correlation between DJ-1 levels in the cerebrospinal fluid and the progression of disabilities in multiple sclerosis patients
    M Hirotani
    Department of Neurology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Mult Scler 14:1056-60. 2008
    ..The aim of this study was to investigate whether the DJ-1 levels were increased in patients with MS and to examine its association with the progression of MS...
  34. pmc Modulation of complement regulatory function and measles virus receptor function by the serine-threonine-rich domains of membrane cofactor protein (CD46)
    K Iwata
    Department of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Biochem J 304:169-75. 1994
    ....
  35. ncbi request reprint Molecular cloning of the complementary DNA for the mouse pyruvate kinase M-2 gene whose expression is dependent upon cell differentiation
    S Izumi
    Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Biochim Biophys Acta 1267:135-8. 1995
    ..Expression of the pyruvate kinase in mouse embryonal carcinoma P19 cells altered according to differentiation stages; high at undifferentiated and low at differentiated stages...
  36. ncbi request reprint Kinetics of fetal cellular and cell-free DNA in the maternal circulation during and after pregnancy: implications for noninvasive prenatal diagnosis
    H Ariga
    Blood Centers of the Pacific, San Francisco, CA 94118, USA
    Transfusion 41:1524-30. 2001
    ..Further studies will be needed to determine the immunologic implications of fetal-maternal DNA exchange and cellular microchimerism...
  37. ncbi request reprint DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor
    K Takahashi
    Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, 4 1 8 Honcho, Kawaguchi, Saitama 332 0012, Japan
    J Biol Chem 276:37556-63. 2001
    ..These results indicate that DJ-1 is a positive regulator of the androgen receptor...
  38. ncbi request reprint Novel role of phosphatidylinositol 3-kinase in CD28-mediated costimulation
    Y Harada
    Research Institute for Biological Sciences, Science University of Tokyo, 2669 Yamazaki, Noda, Chiba 278-0022, Japan
    J Biol Chem 276:9003-8. 2001
    ..Taken together, these data indicate that PI3K, when associated with the YMNM motif, may act as a negative mediator in CD28-mediated IL-2 gene transcription...
  39. pmc c-Myc gene single-strand binding protein-1, MSSP-1, suppresses transcription of alpha-smooth muscle actin gene in chicken visceral smooth muscle cells
    K Kimura
    Department of Neurochemistry and Neuropharmacology, Biomedical Research Center, Osaka University Medical School, 2 2 Yamadaoka, Suita, Osaka 565, Japan
    Nucleic Acids Res 26:2420-5. 1998
    ..In fact, overexpression of MSSP-1 in cultured smooth muscle cells suppresses the promoter activity. These results suggest a novel function of MSSP-1 regarding the transcriptional regulation of alpha-sm actin gene...
  40. ncbi request reprint HLA-B51 and HLA-Bw52 differ by only two amino acids which are in the helical region of the alpha 1 domain
    H Hayashi
    Department of Cell Biology, Stanford University, CA 94305
    J Immunol 142:306-11. 1989
    ..HLA-B51 could have been formed from HLA-Bw52 by the combination of a genetic exchange with HLA-B8 and a point mutation. Similarity of HLA-B51 and HLA-Bw52 with HLA-Bw58 suggest they also share a common ancestor...