Research Topics
Genomes and Genes | Riichiro AbeSummaryAffiliation: Hokkaido University Country: Japan Publications
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Publications
Topical application of anti-angiogenic peptides based on pigment epithelium-derived factor can improve psoriasisRiichiro Abe
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
J Dermatol Sci 57:183-91. 2010..Angiogenic factors, such as vascular endothelial growth factor (VEGF), may dominate the activity of anti-angiogenic factors and accelerate angiogenesis in psoriatic skin...
Pigment epithelium-derived factor prevents melanoma growth via angiogenesis inhibitionRiichiro Abe
Department of Dermatology, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
Curr Pharm Des 14:3802-9. 2008....
Angiogenesis and metastasis inhibitors for the treatment of malignant melanomaRiichiro Abe
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Mini Rev Med Chem 7:649-61. 2007..We also discuss here the involvement of a receptor for advanced glycation end products (RAGE) in angiogenesis, melanoma growth and metastasis, and the therapeutic implications of the blockers of RAGE in this devastating disorder...
Toxic epidermal necrolysis and Stevens-Johnson syndrome: soluble Fas ligand involvement in the pathomechanisms of these diseasesRiichiro Abe
Department of Dermatology, Hokkaido University Graduate School of Medicine, N15 W7, Kita ku, Sapporo 060 8638, Japan
J Dermatol Sci 52:151-9. 2008..An urgent review of the pathophysiology in TEN/SJS is needed to resolve this issue and to determine more effective treatment regimes...
Toxic epidermal necrolysis and Stevens-Johnson syndrome are induced by soluble Fas ligandRiichiro Abe
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Am J Pathol 162:1515-20. 2003....
AGE-RAGE system and carcinogenesisRiichiro Abe
Department of Dermatology, Hokkaido University Graduate School of Medicine, N 15 W 7, Kita ku, Sapporo 060 8638, Japan
Curr Pharm Des 14:940-5. 2008..This paper reviews current knowledge about the role of AGE-RAGE system in the development of various types of cancers...
Overexpression of pigment epithelium-derived factor decreases angiogenesis and inhibits the growth of human malignant melanoma cells in vivoRiichiro Abe
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Am J Pathol 164:1225-32. 2004..PEDF therefore might be a promising novel therapeutic agent for treatment of patients with melanoma...
Regulation of human melanoma growth and metastasis by AGE-AGE receptor interactionsRiichiro Abe
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
J Invest Dermatol 122:461-7. 2004....
Bone marrow transplantation restores epidermal basement membrane protein expression and rescues epidermolysis bullosa model miceYasuyuki Fujita
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
Proc Natl Acad Sci U S A 107:14345-50. 2010..The current conventional BMT techniques have significant potential as a systemic therapeutic approach for the treatment of human EB...
Interleukin-1beta and macrophage migration inhibitory factor (MIF) in dermal fibroblasts mediate UVA-induced matrix metalloproteinase-1 expressionAyumi Honda
Department of Dermatology, Graduate School of Medicine, University of Toyama, Toyama, Japan
J Dermatol Sci 49:63-72. 2008..Matrix metalloproteinases (MMP)-1 is a member of the MMP family and degrades types I and III collagens, which are the major structural components of the dermis...
Tissue regeneration using macrophage migration inhibitory factor-impregnated gelatin microbeads in cutaneous woundsYunan Zhao
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Am J Pathol 167:1519-29. 2005..These findings suggest that MIF is crucial in accelerating cutaneous wound healing and that MIF-impregnated gelatin microbeads represent a promising treatment to facilitate skin wound healing...
CTACK/CCL27 accelerates skin regeneration via accumulation of bone marrow-derived keratinocytesDaisuke Inokuma
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Stem Cells 24:2810-6. 2006....
Expression of macrophage migration inhibitory factor in rat skin during embryonic developmentTadamichi Shimizu
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Exp Dermatol 14:819-23. 2005..Immunohistochemical analysis with an anti-MIF antibody showed a similar distribution to that of the mRNA. Our results suggest that MIF is associated with epidermal and hair follicle development...
Deficient deletion of apoptotic cells by macrophage migration inhibitory factor (MIF) overexpression accelerates photocarcinogenesisAyumi Honda
Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama 930 0194, Japan
Carcinogenesis 30:1597-605. 2009..Collectively, these findings suggest that chronic UVB exposure enhances MIF production, which may inhibit the p53-dependent apoptotic processes and thereby induce photocarcinogenesis in the skin...
Bone marrow-derived cells are not the origin of the cancer stem cells in ultraviolet-induced skin cancerSatomi Ando
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Am J Pathol 174:595-601. 2009..These results indicate that BMDCs are not a major source of malignant keratinocytes in UVB-induced SCC. Therefore, we conclude that BMDCs are not the origin of CSCs in UVB-induced SCC...
Macrophage migration inhibitory factor is essential for eosinophil recruitment in allergen-induced skin inflammationYoko Yoshihisa
Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama, Japan
J Invest Dermatol 131:925-31. 2011..These findings indicate that MIF can induce eosinophil accumulation in the skin. Therefore, the targeted inhibition of MIF might be a promising new therapeutic strategy for allergic skin diseases...
Collagen XVII participates in keratinocyte adhesion to collagen IV, and in p38MAPK-dependent migration and cell signalingHongjiang Qiao
Creative Research Initiative, Hokkaido University, Sapporo, Japan
J Invest Dermatol 129:2288-95. 2009....
Ultraviolet A-induced production of matrix metalloproteinase-1 is mediated by macrophage migration inhibitory factor (MIF) in human dermal fibroblastsHirokazu Watanabe
Department of Dermatology, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo 060 8638, Japan
J Biol Chem 279:1676-83. 2004..Taken together, these results suggest that MIF is involved in the up-regulation of UVA-induced MMP-1 in dermal fibroblasts through PKC-, PKA-, Src family tyrosine kinase-, MAPK-, c-Jun-, and AP-1-dependent pathways...
DNA vaccination against macrophage migration inhibitory factor improves atopic dermatitis in murine modelsAsuka Hamasaka
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
J Allergy Clin Immunol 124:90-9. 2009..Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that has been implicated in the pathogenesis of AD. Recently, we developed a novel DNA vaccine that generates neutralizing endogenous anti-MIF antibodies...
Macrophage migration inhibitory factor is induced by thrombin and factor Xa in endothelial cellsTadamichi Shimizu
Departments of Dermatology and Molecular Biochemistry, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
J Biol Chem 279:13729-37. 2004..Taken together, these results suggest that MIF contributes to the inflammatory phase of the wound healing process in concert with thrombin and FXa via PAR-1 and PAR-2...
Impaired contact hypersensitivity in macrophage migration inhibitory factor-deficient miceTadamichi Shimizu
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Eur J Immunol 33:1478-87. 2003..005). Taken together, these results indicate that MIF is pivotal in the regulation of cutaneous immune responses and plays a central role in LC migration and T cell proliferation for the CHS response...
Mesenchymal stem cells are recruited into wounded skin and contribute to wound repair by transdifferentiation into multiple skin cell typeMikako Sasaki
Department of Dermatology, Hokkaido University Graduate School of Medicine, N 15 W 7 Kita ku, Sapporo, Japan
J Immunol 180:2581-7. 2008..Taken together, we have demonstrated that MSCs contribute to wound repair via processes involving MSCs differentiation various cell components of the skin...
Rapid immunochromatographic test for serum granulysin is useful for the prediction of Stevens-Johnson syndrome and toxic epidermal necrolysisYasuyuki Fujita
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
J Am Acad Dermatol 65:65-8. 2011..We have reported that serum granulysin levels are elevated (cut off: 10 ng/mL) in patients with SJS/TEN before generalized blisters form...
Type XVII collagen is a key player in tooth enamel formationTakuya Asaka
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Am J Pathol 174:91-100. 2009..In conclusion, COL17 deficiency disrupts the epithelial-mesenchymal interactions, leading to both defective ameloblast differentiation and enamel malformation...
Small-diameter porous poly (epsilon-caprolactone) films enhance adhesion and growth of human cultured epidermal keratinocyte and dermal fibroblast cellsJames R McMillan
Department of Dermatology, Hokkaido University, Graduate School of Medicine, Sapporo, Japan
Tissue Eng 13:789-98. 2007..These characteristics are considered important in developing grafts for use in the treatment of human skin wounds...
Protective effects of platinum nanoparticles against UV-light-induced epidermal inflammationYoko Yoshihisa
Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama, Japan
Exp Dermatol 19:1000-6. 2010..These results suggest that nano-Pt effectively protects against UV-induced inflammation by decreasing ROS production and inhibiting apoptosis in keratinocytes...
Presence of circulating CCR10+ T cells and elevated serum CTACK/CCL27 in the early stage of mycosis fungoidesYasuyuki Fujita
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Clin Cancer Res 12:2670-5. 2006..Recently, CCR10 and CTACK/CCL27 were proposed to play a role in the recruitment of other types of cutaneous T cell lymphoma. We examined the expression of CCR10 in peripheral blood and serum CTACK/CCL27 levels in patients with MF...
Establishment of a novel experimental model of human angiosarcoma and a VEGF-targeting therapeutic experimentDaichi Hoshina
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
J Dermatol Sci 70:116-22. 2013..One factor in delaying the therapy development is the limitation of experimental models...
Expression of c-maf and mafB genes in the skin during rat embryonic developmentAkihiko Ogata
Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan
Acta Histochem 106:65-7. 2004..MafB showed similar expression patterns as c-maf. Our findings indicate that c-maf and mafB are involved in embryonic development of epidermis and hair follicles...
Stevens-Johnson syndrome/toxic epidermal necrolysis mouse model generated by using PBMCs and the skin of patientsNao Saito
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
J Allergy Clin Immunol 131:434-41.e1-9. 2013..Currently, there is no animal model that reproduces SJS/TEN symptoms...
Histochemical analysis of macrophage migration inhibitory factor in psoriasis vulgarisTadamichi Shimizu
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan
Histochem Cell Biol 118:251-7. 2002....
Non-Hodgkin lymphoma preceded by recalcitrant eczemaKen Natsuga
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Eur J Haematol 79:369-70. 2007
Increase in macrophage migration inhibitory factor levels in lacrimal fluid of patients with severe atopic dermatitisNobuyoshi Kitaichi
Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, 060 8638, Sapporo, Japan
Graefes Arch Clin Exp Ophthalmol 244:825-8. 2006..Although serum MIF levels may be elevated in severe atopic dermatitis, the quantity of MIF in regional ocular fluid remains unknown. We measured MIF levels in tears (lacrimal fluid) of patients with atopic dermatitis...
Increased soluble Fas ligand levels in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis preceding skin detachmentJunko Murata
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
J Allergy Clin Immunol 122:992-1000. 2008....
Clinical approaches toward tumor angiogenesis: past, present and futureYasuyuki Fujita
Department of Dermatology, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
Curr Pharm Des 14:3820-34. 2008..Further investigations of combined therapies including angiogenesis inhibitors will shed light on the treatment of advanced and metastasized malignancies...
Induction of macrophage migration inhibitory factor precedes the onset of acute tonsillitisTadamichi Shimizu
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Mediators Inflamm 13:293-5. 2004..Since MIF is an initiator of other proinflammatory cytokines, we suggest that the induction of MIF may precede other inflammatory conditions...
Coexistence of a systemic lupus erythematosus and porphyria cutanea tarda: case successfully improved by avoidance of sun exposureJunko Murata
Department of Dermatology, Hokkaido University Graduate School of Medicine, Kita-ku, Sapporo, Japan
Int J Dermatol 45:435-7. 2006
Zinc dental fillings and palmoplantar pustulosisTeruki Yanagi
Department of Dermatology, Hokkaido University Graduate School of Medicine, N15W7, Kita-ku, Sapporo 060-8638, Japan
Lancet 366:1050. 2005
[Therapy for skin disease using bone marrow cells]Riichiro Abe
Department of Dermatology, Hokkaido University Graduate School of Medicine
Nihon Rinsho Meneki Gakkai Kaishi 34:85-90. 2011..The current conventional BMT techniques have significant potential as a systemic therapeutic approach for the treatment of human EB...
Soluble Fas ligand: is it a critical mediator of toxic epidermal necrolysis and Stevens-Johnson syndrome?Junko Murata
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
J Invest Dermatol 127:744-5. 2007..In addition to sFasL, other factors, including predisposing genetic factors, should also be investigated to determine their precise pathogenesis in TEN and SJS...
Prevalent LIPH founder mutations lead to loss of P2Y5 activation ability of PA-PLA1alpha in autosomal recessive hypotrichosisSatoru Shinkuma
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Hum Mutat 31:602-10. 2010..These results suggest defective activation of P2Y5 due to reduced 2-acyl lysophosphatidic acid production by the mutant PA-PLA(1)alpha is involved in the pathogenesis of ARH...
Multicentric reticulohistiocytosis associated with rheumatoid arthritisDaichi Hoshina
Department of Dermatology, Hokkaido University Graduate School of Medicine, Kita-ku, Sapporo, Japan
Rheumatol Int 25:553-4. 2005..MRH may be misdiagnosed as RA, but evaluation of the time course of specific symptoms can greatly help in the correct diagnosis...
Spontaneous remission of solitary-type infantile myofibromatosisKazuhiro Kikuchi
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Tokyo, Japan
Case Rep Dermatol 3:181-5. 2011..The low frequency of mitosis was definitive for a diagnosis of infantile myofibromatosis. We present a cutaneous solitary-type case of infantile myofibromatosis. Following incisional biopsy, the tumor remitted spontaneously...
Granulomatous arteritis in cutaneous lesions of Churg-Strauss syndromeKo Ron Chen
Department of Dermatology, Ogikubo Hospital, Tokyo, Japan
J Cutan Pathol 34:330-7. 2007....
Clinical images: Drumstick-like fingers indicating psoriatic onycho-pachydermo periostitisAkiko Tsubota
Tomakomai Ohji General Hospital and Hokkaido University Graduate School of Medicine, Sapporo, Japan
Arthritis Rheum 52:2954. 2005
Immunological reconstitution after autologous hematopoietic stem cell transplantation in patients with systemic sclerosis: relationship between clinical benefits and intensity of immunosuppressionToshiyuki Bohgaki
Department of Medicine II, Hokkaido University Graduate School of Medicine, N15, W7, Kita ku, Sapporo 060 8638, Japan
J Rheumatol 36:1240-8. 2009..To analyze the relationship between clinical benefits and immunological changes in patients with systemic sclerosis (SSc) treated with autologous hematopoietic stem cell transplantation (HSCT)...
Minodronate, a newly developed nitrogen-containing bisphosphonate, suppresses melanoma growth and improves survival in nude mice by blocking vascular endothelial growth factor signalingSho ichi Yamagishi
Department of Internal Medicine III, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
Am J Pathol 165:1865-74. 2004..The present study provides a novel potential therapeutic strategy for the treatment of melanoma...
Angiogenesis induced by advanced glycation end products and its prevention by cerivastatinTamami Okamoto
Division of Endocrinology and Metabolism, Kurume University School of Medicine, Kurume 830-0011, Japan
FASEB J 16:1928-30. 2002..By blocking AGE-RAGE signaling pathways, cerivastatin might be a promising remedy for treating patients with proliferative diabetic retinopathy...
Pigment epithelium-derived factor inhibits TNF-alpha-induced interleukin-6 expression in endothelial cells by suppressing NADPH oxidase-mediated reactive oxygen species generationSho ichi Yamagishi
Department of Internal Medicine III, Kurume University School of Medicine, Kurume 830 0011, Japan
J Mol Cell Cardiol 37:497-506. 2004..Our present study suggests that PEDF may play an important role in the development and progression of atherosclerosis...
Mycosis fungoides bullosaKen Natsuga
Arch Dermatol 142:793-5. 2006
Peginterferon alfa-2b for mycosis fungoidesTeruki Yanagi
Arch Dermatol 142:649-51. 2006
Macrophage migration inhibitory factor (MIF) in bullous pemphigoidYukie Asano
J Dermatol Sci 49:95-7. 2008
Increased macrophage migration inhibitory factor (MIF) in the sera of patients with extensive alopecia areataTadamichi Shimizu
J Invest Dermatol 118:555-7. 2002
Chain saw blade granuloma: reaction to a deeply embedded metal fragmentRinko Osawa
Arch Dermatol 142:1079-80. 2006
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomesAn Chi
Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, USA
J Proteome Res 5:3135-44. 2006..The sharing of proteins between melanosomes and other lysosome-related organelles suggests a common evolutionary origin. This work represents a model for the study of the biogenesis of lysosome-related organelles...
Disseminated subcutaneous nodules alone as manifestations of Churg-Strauss syndromeRiichiro Abe
Int J Dermatol 47:532-3. 2008
A novel polymorphic CAAT/enhancer-binding protein beta element in the FasL gene promoter alters Fas ligand expression: a candidate background gene in African American systemic lupus erythematosus patientsJianming Wu
Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama, Birmingham, AL 35294 0006, USA
J Immunol 170:132-8. 2003..This functionally significant SNP demonstrates the potential importance of SNPs in regulatory regions and suggests that differences in the regulation of FasL expression may contribute to the development of the autoimmune phenotype...
Lupus erythematosus panniculitis (lupus profundus): clinical, histopathological, and molecular analysis of nine casesCesare Massone
Department of Dermatology, Medical University of Graz, Graz, Austria
J Cutan Pathol 32:396-404. 2005....
The use of ELISA to detect desmoglein antibodies in a pregnant woman and fetusSatomi Okubo
Arch Dermatol 139:1217-8. 2003
Plasma exchange; a promising treatment for toxic epidermal necrolysis with AIDSToshifumi Nomura
AIDS 18:2446-8. 2004
