Akihiko Hiyama


Country: Japan


  1. Hiyama A, Katoh H, Sakai D, Sato M, Tanaka M, Nukaga T, et al. Correlation analysis of sagittal alignment and skeletal muscle mass in patients with spinal degenerative disease. Sci Rep. 2018;8:15492 pubmed publisher
    ..The SMM might be one of the important factors that influenced the posterior inclination of the pelvis in symptomatic spinal patients, especially in cervical spine disease. ..
  2. Hiyama A, Morita K, Sakai D, Watanabe M. CCN family member 2/connective tissue growth factor (CCN2/CTGF) is regulated by Wnt-β-catenin signaling in nucleus pulposus cells. Arthritis Res Ther. 2018;20:217 pubmed publisher
    ..Understanding the balance between Wnt-β-catenin signaling and CCN2 is necessary for developing therapeutic alternatives for the treatment of IVD degeneration. ..
  3. Hiyama A, Watanabe M, Katoh H, Sato M, Nagai T, Mochida J. Relationships between posterior ligamentous complex injury and radiographic parameters in patients with thoracolumbar burst fractures. Injury. 2015;46:392-8 pubmed publisher
  4. Hiyama A, Watanabe M, Katoh H, Sato M, Sakai D, Mochida J. Evaluation of quality of life and neuropathic pain in patients with low back pain using the Japanese Orthopedic Association Back Pain Evaluation Questionnaire. Eur Spine J. 2015;24:503-12 pubmed publisher
    ..A comparison of JOABPEQ scores between LBP patients assessed by PDQ-J as having neuropathic pain or nociceptive pain suggests that neuropathic pain affects the social and psychological well-being of LBP patients. ..
  5. Hiyama A, Katoh H, Sakai D, Sato M, Tanaka M, Watanabe M. Prevalence of diffuse idiopathic skeletal hyperostosis (DISH) assessed with whole-spine computed tomography in 1479 subjects. BMC Musculoskelet Disord. 2018;19:178 pubmed publisher
    ..It is for the first time report that we have studied the location of ossification in detail using the axial images of whole spine CT. We hope this study will enhance the understanding of the characteristics of DISH. ..
  6. Hiyama A, Watanabe M, Katoh H, Sato M, Sakai D, Mochida J. Effect of depression and neuropathic pain using questionnaires on quality of life in patients with low back pain; cross-sectional retrospective study. Eur Spine J. 2016;25:2750-60 pubmed publisher
    ..This is the first study to use the SDS-Zung and PDQ-J screening questionnaires to estimate the presence of neuropathic pain associated with depressive symptoms in LBP patients and to evaluate the impact of these on QOL. ..
  7. Hiyama A, Sakai D, Risbud M, Tanaka M, Arai F, Abe K, et al. Enhancement of intervertebral disc cell senescence by WNT/?-catenin signaling-induced matrix metalloproteinase expression. Arthritis Rheum. 2010;62:3036-47 pubmed publisher
    ..We hypothesize that the activation of WNT/?-catenin signaling may lead to an increased breakdown of the matrix, thereby promoting IVD degeneration. ..
  8. Hiyama A, Sakai D, Tanaka M, Arai F, Nakajima D, Abe K, et al. The relationship between the Wnt/?-catenin and TGF-?/BMP signals in the intervertebral disc cell. J Cell Physiol. 2011;226:1139-48 pubmed publisher
  9. Hiyama A, Sakai D, Arai F, Nakajima D, Yokoyama K, Mochida J. Effects of a glycogen synthase kinase-3? inhibitor (LiCl) on c-myc protein in intervertebral disc cells. J Cell Biochem. 2011;112:2974-86 pubmed publisher
    ..These findings provide new insight into the regulation and maintenance of cell proliferation in nucleus pulposus cells. ..

More Information


  1. request reprint
    Hiyama A, Sakai D, Watanabe M, Katoh H, Sato M, Mochida J. Sagittal alignment of the cervical spine in adolescent idiopathic scoliosis: a comparative study of 42 adolescents with idiopathic scoliosis and 24 normal adolescents. Eur Spine J. 2016;25:3226-3233 pubmed
    ..Cervical spine alignment was affected by the thoracic deformity in the sagittal plane, as shown by the reduction in the CL after the operation. These findings suggest that TK may be a cause of cervical kyphosis in AIS patients. ..
  2. Hiyama A, Katoh H, Sakai D, Tanaka M, Sato M, Watanabe M. Clinical impact of JOABPEQ mental health scores in patients with low back pain: Analysis using the neuropathic pain screening tool painDETECT. J Orthop Sci. 2017;22:1009-1014 pubmed publisher
    ..We found that psychological factors may modify pain intensity and may lead to an exaggerated or histrionic presentation of the pain, or neuropathic LBP may be exacerbating psychological factors. ..
  3. Hiyama A, Yokoyama K, Nukaga T, Sakai D, Mochida J. A complex interaction between Wnt signaling and TNF-? in nucleus pulposus cells. Arthritis Res Ther. 2013;15:R189 pubmed publisher
    ..We speculate that blocking this pathway might protect nucleus pulposus cells against degeneration. ..
  4. Hiyama A, Arai F, Sakai D, Yokoyama K, Mochida J. The effects of oxygen tension and antiaging factor Klotho on Wnt signaling in nucleus pulposus cells. Arthritis Res Ther. 2012;14:R105 pubmed publisher
    ..These results suggest that the expression of Klotho is regulated by the balance between upregulation and downregulation of Wnt signaling. ..