Hiyama A, Katoh H, Sakai D, Sato M, Tanaka M, Nukaga T, et al
. Correlation analysis of sagittal alignment and skeletal muscle mass in patients with spinal degenerative disease. Sci Rep. 2018;8:15492 pubmed publisher
..The SMM might be one of the important factors that influenced the posterior inclination of the pelvis in symptomatic spinal patients, especially in cervical spine disease. ..
Hiyama A, Morita K, Sakai D, Watanabe M. CCN family member 2/connective tissue growth factor (CCN2/CTGF) is regulated by Wnt-β-catenin signaling in nucleus pulposus cells. Arthritis Res Ther. 2018;20:217 pubmed publisher
..Understanding the balance between Wnt-β-catenin signaling and CCN2 is necessary for developing therapeutic alternatives for the treatment of IVD degeneration. ..
Hiyama A, Watanabe M, Katoh H, Sato M, Nagai T, Mochida J. Relationships between posterior ligamentous complex injury and radiographic parameters in patients with thoracolumbar burst fractures. Injury. 2015;46:392-8 pubmed publisher
Hiyama A, Watanabe M, Katoh H, Sato M, Sakai D, Mochida J. Evaluation of quality of life and neuropathic pain in patients with low back pain using the Japanese Orthopedic Association Back Pain Evaluation Questionnaire. Eur Spine J. 2015;24:503-12 pubmed publisher
..A comparison of JOABPEQ scores between LBP patients assessed by PDQ-J as having neuropathic pain or nociceptive pain suggests that neuropathic pain affects the social and psychological well-being of LBP patients. ..
Hiyama A, Katoh H, Sakai D, Sato M, Tanaka M, Watanabe M. Prevalence of diffuse idiopathic skeletal hyperostosis (DISH) assessed with whole-spine computed tomography in 1479 subjects. BMC Musculoskelet Disord. 2018;19:178 pubmed publisher
..It is for the first time report that we have studied the location of ossification in detail using the axial images of whole spine CT. We hope this study will enhance the understanding of the characteristics of DISH. ..
Hiyama A, Watanabe M, Katoh H, Sato M, Sakai D, Mochida J. Effect of depression and neuropathic pain using questionnaires on quality of life in patients with low back pain; cross-sectional retrospective study. Eur Spine J. 2016;25:2750-60 pubmed publisher
..This is the first study to use the SDS-Zung and PDQ-J screening questionnaires to estimate the presence of neuropathic pain associated with depressive symptoms in LBP patients and to evaluate the impact of these on QOL. ..
Hiyama A, Sakai D, Risbud M, Tanaka M, Arai F, Abe K, et al
. Enhancement of intervertebral disc cell senescence by WNT/?-catenin signaling-induced matrix metalloproteinase expression. Arthritis Rheum. 2010;62:3036-47 pubmed publisher
..We hypothesize that the activation of WNT/?-catenin signaling may lead to an increased breakdown of the matrix, thereby promoting IVD degeneration. ..
Hiyama A, Sakai D, Tanaka M, Arai F, Nakajima D, Abe K, et al
. The relationship between the Wnt/?-catenin and TGF-?/BMP signals in the intervertebral disc cell. J Cell Physiol. 2011;226:1139-48 pubmed publisher
Hiyama A, Sakai D, Arai F, Nakajima D, Yokoyama K, Mochida J. Effects of a glycogen synthase kinase-3? inhibitor (LiCl) on c-myc protein in intervertebral disc cells. J Cell Biochem. 2011;112:2974-86 pubmed publisher
..These findings provide new insight into the regulation and maintenance of cell proliferation in nucleus pulposus cells. ..