Akihiko Hiyama

Summary

Country: Japan

Publications

  1. ncbi request reprint Sagittal alignment of the cervical spine in adolescent idiopathic scoliosis: a comparative study of 42 adolescents with idiopathic scoliosis and 24 normal adolescents
    Akihiko Hiyama
    Department of Orthopaedic Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259 1193, Japan
    Eur Spine J 25:3226-3233. 2016
  2. doi request reprint Effect of depression and neuropathic pain using questionnaires on quality of life in patients with low back pain; cross-sectional retrospective study
    Akihiko Hiyama
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259 1193, Japan
    Eur Spine J 25:2750-60. 2016
  3. doi request reprint Evaluation of quality of life and neuropathic pain in patients with low back pain using the Japanese Orthopedic Association Back Pain Evaluation Questionnaire
    Akihiko Hiyama
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259 1193, Japan
    Eur Spine J 24:503-12. 2015
  4. doi request reprint Relationships between posterior ligamentous complex injury and radiographic parameters in patients with thoracolumbar burst fractures
    Akihiko Hiyama
    Department of Orthopaedic Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1193, Japan Electronic address
    Injury 46:392-8. 2015
  5. pmc A complex interaction between Wnt signaling and TNF-α in nucleus pulposus cells
    Akihiko Hiyama
    Arthritis Res Ther 15:R189. 2013
  6. pmc The effects of oxygen tension and antiaging factor Klotho on Wnt signaling in nucleus pulposus cells
    Akihiko Hiyama
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1193, Japan
    Arthritis Res Ther 14:R105. 2012
  7. pmc Enhancement of intervertebral disc cell senescence by WNT/β-catenin signaling-induced matrix metalloproteinase expression
    Akihiko Hiyama
    Tokai University School of Medicine, Isehara, Japan
    Arthritis Rheum 62:3036-47. 2010
  8. doi request reprint The relationship between the Wnt/β-catenin and TGF-β/BMP signals in the intervertebral disc cell
    Akihiko Hiyama
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    J Cell Physiol 226:1139-48. 2011
  9. doi request reprint Effects of a glycogen synthase kinase-3β inhibitor (LiCl) on c-myc protein in intervertebral disc cells
    Akihiko Hiyama
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1193, Japan
    J Cell Biochem 112:2974-86. 2011
  10. doi request reprint Transplantation of mesenchymal stem cells in a canine disc degeneration model
    Akihiko Hiyama
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, 259 1193, Japan
    J Orthop Res 26:589-600. 2008

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Sagittal alignment of the cervical spine in adolescent idiopathic scoliosis: a comparative study of 42 adolescents with idiopathic scoliosis and 24 normal adolescents
    Akihiko Hiyama
    Department of Orthopaedic Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259 1193, Japan
    Eur Spine J 25:3226-3233. 2016
    ....
  2. doi request reprint Effect of depression and neuropathic pain using questionnaires on quality of life in patients with low back pain; cross-sectional retrospective study
    Akihiko Hiyama
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259 1193, Japan
    Eur Spine J 25:2750-60. 2016
    ..The present study investigated the percentage of low back pain (LBP) patients who have depressive symptoms and neuropathic pain and analyzed the effects of these on the quality of life (QOL) in these patients...
  3. doi request reprint Evaluation of quality of life and neuropathic pain in patients with low back pain using the Japanese Orthopedic Association Back Pain Evaluation Questionnaire
    Akihiko Hiyama
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259 1193, Japan
    Eur Spine J 24:503-12. 2015
    ....
  4. doi request reprint Relationships between posterior ligamentous complex injury and radiographic parameters in patients with thoracolumbar burst fractures
    Akihiko Hiyama
    Department of Orthopaedic Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1193, Japan Electronic address
    Injury 46:392-8. 2015
    ....
  5. pmc A complex interaction between Wnt signaling and TNF-α in nucleus pulposus cells
    Akihiko Hiyama
    Arthritis Res Ther 15:R189. 2013
    ..The goal of the present study was to examine the effect of the interaction between Wnt signaling and the proinflammatory cytokine TNF-α in nucleus pulposus cells...
  6. pmc The effects of oxygen tension and antiaging factor Klotho on Wnt signaling in nucleus pulposus cells
    Akihiko Hiyama
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1193, Japan
    Arthritis Res Ther 14:R105. 2012
    ..We investigated the expression of Klotho, a newly identified antiaging gene, and whether its regulation is attributable to the suppression of Wnt signaling...
  7. pmc Enhancement of intervertebral disc cell senescence by WNT/β-catenin signaling-induced matrix metalloproteinase expression
    Akihiko Hiyama
    Tokai University School of Medicine, Isehara, Japan
    Arthritis Rheum 62:3036-47. 2010
    ..To determine whether intervertebral disc (IVD) cells express β-catenin and to assess the role of the WNT/β-catenin signaling pathway in cellular senescence and aggrecan synthesis...
  8. doi request reprint The relationship between the Wnt/β-catenin and TGF-β/BMP signals in the intervertebral disc cell
    Akihiko Hiyama
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    J Cell Physiol 226:1139-48. 2011
    ....
  9. doi request reprint Effects of a glycogen synthase kinase-3β inhibitor (LiCl) on c-myc protein in intervertebral disc cells
    Akihiko Hiyama
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1193, Japan
    J Cell Biochem 112:2974-86. 2011
    ..These findings provide new insight into the regulation and maintenance of cell proliferation in nucleus pulposus cells...
  10. doi request reprint Transplantation of mesenchymal stem cells in a canine disc degeneration model
    Akihiko Hiyama
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, 259 1193, Japan
    J Orthop Res 26:589-600. 2008
    ..The results of this study suggest that MSC transplantation may contribute to the maintenance of IVD immune privilege by the differentiation of transplanted MSCs into cells expressing FasL...
  11. doi request reprint Low-intensity pulsed ultrasound stimulation enhances TIMP-1 in nucleus pulposus cells and MCP-1 in macrophages in the rat
    Hiroko Omi
    Departmnet of Orthopaedic Surgery, Surgical Science and Center for Regenerative Medicine, Tokai University School of Medicine, Shimokasuya 143, Isehara, Kanagawa, 259 1143, Japan
    J Orthop Res 26:865-71. 2008
    ....
  12. doi request reprint Effect of cell number on mesenchymal stem cell transplantation in a canine disc degeneration model
    Kenji Serigano
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, Shimokasuya 143, Isehara, Kanagawa 259 1193, Japan
    J Orthop Res 28:1267-75. 2010
    ..It is suggested that maintenance of extracellular matrix by its production from transplanted cells and/or resident cells is important for checking the progression of structural disruption that leads to disc degeneration...
  13. pmc C-Fos regulation by the MAPK and PKC pathways in intervertebral disc cells
    Katsuya Yokoyama
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, Kanagawa, Japan Research Center for Regenerative Medicine, Tokai University School of Medicine, Kanagawa, Japan
    PLoS ONE 8:e73210. 2013
    ..We investigated whether c-fos is activated in relation to mitogen-activated protein kinases (MAPKs) and the protein kinase C (PKC) pathway in nucleus pulposus (NP) cells...
  14. ncbi request reprint Synergistic effect of low-intensity pulsed ultrasound on growth factor stimulation of nucleus pulposus cells
    Akihiko Hiyama
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medcine, Boseidai, Isehara, Kanagawa 259 1193, Japan
    J Orthop Res 25:1574-81. 2007
    ..Because LIPUS is safe and noninvasive, the results of the present study suggest that it would be a promising new therapy for prevention of intervertebral disc degeneration, which is said to be one of the primary causes of low back pain...
  15. doi request reprint A Cre knock-in mouse line on the Sickle tail locus induces recombination in the notochord and intervertebral disks
    Koichiro Abe
    Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Kanagawa, Japan
    Genesis 50:758-65. 2012
    ..5. These results suggest that Skt(cre) mice are useful for exploring the fate specification of notochordal cells and creating models for IVD-related skeletal diseases...
  16. doi request reprint The expression and role of non-canonical (PKC) signaling in nucleus pulposus cell metabolism
    Fumiyuki Arai
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1193, Japan
    J Orthop Res 30:1478-85. 2012
    ..Crosstalk in these signaling pathways plays an important role in the regulation of IVD homeostasis...
  17. doi request reprint Response to tumor necrosis factor-α mediated inflammation involving activation of prostaglandin E2 and Wnt signaling in nucleus pulposus cells
    Akihiko Hiyama
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1193, Japan
    J Orthop Res 33:1756-68. 2015
    ..These findings may help identify the underlying mechanism and role of Wnt signaling in IVD degeneration...
  18. ncbi request reprint Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral disc
    Daisuke Sakai
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259 1193, Japan
    Biomaterials 27:335-45. 2006
    ..MSCs may serve as a valuable resource in cell transplantation therapy for degenerative disc disease...
  19. doi request reprint CCAAT/enhancer binding protein β regulates the expression of tumor necrosis factor-α in the nucleus pulposus cells
    Akihiko Hiyama
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, 259 1193, Kanagawa, Japan
    J Orthop Res 34:865-75. 2016
    ..Our findings may open a new avenue toward the understanding of the cellular and molecular mechanisms of IVD cells. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:865-875, 2016. ..