W Yasui

Summary

Affiliation: Hiroshima University
Country: Japan

Publications

  1. ncbi request reprint Expression of POT1 is associated with tumor stage and telomere length in gastric carcinoma
    Tomohiro Kondo
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Cancer Res 64:523-9. 2004
  2. ncbi request reprint Expression and localization of Reg IV in human neoplastic and non-neoplastic tissues: Reg IV expression is associated with intestinal and neuroendocrine differentiation in gastric adenocarcinoma
    Naohide Oue
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima, Japan
    J Pathol 207:185-98. 2005
  3. pmc Reg IV is a direct target of intestinal transcriptional factor CDX2 in gastric cancer
    Yutaka Naito
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    PLoS ONE 7:e47545. 2012
  4. doi request reprint Molecular pathology of gastric cancer: research and practice
    Wataru Yasui
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Minami Ku, Hiroshima, Japan
    Pathol Res Pract 207:608-12. 2011
  5. pmc In silico analysis of gastric carcinoma Serial Analysis of Gene Expression libraries reveals different profiles associated with ethnicity
    Francisco J Ossandon
    Laboratory of Molecular Pathology and Epidemiology, Centro Investigaciones Medicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Mol Cancer 7:22. 2008
  6. ncbi request reprint Molecular targeting therapy for cancer: the Twelfth International Symposium of the Hiroshima Cancer Seminar, November 2002
    Wataru Yasui
    Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551
    Cancer Sci 94:221-3. 2003
  7. ncbi request reprint New approaches to identification of biomarkers for early cancer detection: The Thirteenth International Symposium of the Hiroshima Cancer Seminar, October 2003
    Wataru Yasui
    Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, Minami Ku, Hiroshima 734 8551, Japan
    Cancer Sci 95:193-5. 2004
  8. ncbi request reprint Molecular pathobiology of gastric cancer
    W Yasui
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Minami Ku, Hiroshima, Japan
    Scand J Surg 95:225-31. 2006
  9. ncbi request reprint Cancer and epigenetics--basic research and clinical implications: Joint Meeting of the Fourteenth International Symposium of the Hiroshima Cancer Seminar and the Eighth Meeting of the Tottori Bioscience Promotion Foundation, October 2004
    Wataru Yasui
    Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Cancer Sci 96:245-8. 2005
  10. ncbi request reprint Transcriptome dissection of gastric cancer: identification of novel diagnostic and therapeutic targets from pathology specimens
    Wataru Yasui
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Pathol Int 59:121-36. 2009

Collaborators

Detail Information

Publications107 found, 100 shown here

  1. ncbi request reprint Expression of POT1 is associated with tumor stage and telomere length in gastric carcinoma
    Tomohiro Kondo
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Cancer Res 64:523-9. 2004
    ..Moreover, changes in POT1 expression levels may be associated with stomach carcinogenesis and GC progression...
  2. ncbi request reprint Expression and localization of Reg IV in human neoplastic and non-neoplastic tissues: Reg IV expression is associated with intestinal and neuroendocrine differentiation in gastric adenocarcinoma
    Naohide Oue
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima, Japan
    J Pathol 207:185-98. 2005
    ....
  3. pmc Reg IV is a direct target of intestinal transcriptional factor CDX2 in gastric cancer
    Yutaka Naito
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    PLoS ONE 7:e47545. 2012
    ..Chromatin immunoprecipitation assays showed that CDX2 binds directly to the 5'-flanking region of REG4. These results indicate that CDX2 protein directly regulates Reg IV expression...
  4. doi request reprint Molecular pathology of gastric cancer: research and practice
    Wataru Yasui
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Minami Ku, Hiroshima, Japan
    Pathol Res Pract 207:608-12. 2011
    ..Only a minor population of gastric cancer cells reveals the properties of cancer stem cells, and CD44 is one of the markers for gastric cancer stem cells. The origin of gastric cancer stem cells remains to be elucidated...
  5. pmc In silico analysis of gastric carcinoma Serial Analysis of Gene Expression libraries reveals different profiles associated with ethnicity
    Francisco J Ossandon
    Laboratory of Molecular Pathology and Epidemiology, Centro Investigaciones Medicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Mol Cancer 7:22. 2008
    ..These expression differences might contribute to explain the disparate outcome between the West and the East...
  6. ncbi request reprint Molecular targeting therapy for cancer: the Twelfth International Symposium of the Hiroshima Cancer Seminar, November 2002
    Wataru Yasui
    Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551
    Cancer Sci 94:221-3. 2003
  7. ncbi request reprint New approaches to identification of biomarkers for early cancer detection: The Thirteenth International Symposium of the Hiroshima Cancer Seminar, October 2003
    Wataru Yasui
    Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, Minami Ku, Hiroshima 734 8551, Japan
    Cancer Sci 95:193-5. 2004
  8. ncbi request reprint Molecular pathobiology of gastric cancer
    W Yasui
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Minami Ku, Hiroshima, Japan
    Scand J Surg 95:225-31. 2006
    ..g., RegIV and claudin-18 can be identified. Advances in our understanding of the genetic and molecular bases lead to improved diagnosis, personalised medicine and prevention of gastric cancer...
  9. ncbi request reprint Cancer and epigenetics--basic research and clinical implications: Joint Meeting of the Fourteenth International Symposium of the Hiroshima Cancer Seminar and the Eighth Meeting of the Tottori Bioscience Promotion Foundation, October 2004
    Wataru Yasui
    Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Cancer Sci 96:245-8. 2005
  10. ncbi request reprint Transcriptome dissection of gastric cancer: identification of novel diagnostic and therapeutic targets from pathology specimens
    Wataru Yasui
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Pathol Int 59:121-36. 2009
    ..Information obtained from transcriptome dissection greatly contributes to diagnosis and treatment of gastric cancer...
  11. ncbi request reprint Search for new biomarkers of gastric cancer through serial analysis of gene expression and its clinical implications
    Wataru Yasui
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Minami Ku, Hiroshima 734 8551, Japan
    Cancer Sci 95:385-92. 2004
    ....
  12. ncbi request reprint Chromatin and cancer: the Eleventh International Symposium of the Hiroshima Cancer Seminar, November 2001
    Wataru Yasui
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8551, Japan
    Jpn J Cancer Res 93:467-9. 2002
  13. ncbi request reprint Histone acetylation and gastrointestinal carcinogenesis
    Wataru Yasui
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Ann N Y Acad Sci 983:220-31. 2003
    ..Therefore, histone acetylation should be a promising target for cancer therapy, especially against invasive and metastatic disease, but also for cancer prevention...
  14. ncbi request reprint DNA methylation status of hMLH1, p16(INK4a), and CDH1 is not associated with mRNA expression levels of DNA methyltransferase and DNA demethylase in gastric carcinomas
    N Oue
    First Department of Pathology, Hiroshima University School of Medicine, Minami-ku, Hiroshima 734-8551, Japan
    Oncol Rep 8:1085-9. 2001
    ....
  15. ncbi request reprint Increased expression but not genetic alteration of BRG1, a component of the SWI/SNF complex, is associated with the advanced stage of human gastric carcinomas
    K Sentani
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
    Pathobiology 69:315-20. 2001
    ..These results suggest that, although genetic abnormality of BRG1 might be rare, an increased expression of BRG1 might be associated with the development and progression of gastric carcinoma...
  16. ncbi request reprint Expression of cell-cycle-regulating transcription factor E2F-1 in colorectal carcinomas
    W Yasui
    First Department of Pathology, Hiroshima University School of Medicine, Hiroshima, Japan
    Pathobiology 67:174-9. 1999
    ..Reduced expression of p27(Kip1) was confirmed to be significantly correlated with deep tumor invasion and presence of metastasis. No correlation was evident between overexpression of E2F-1 and reduced p27(Kip1) expression...
  17. ncbi request reprint Down-regulation of the claudin-18 gene, identified through serial analysis of gene expression data analysis, in gastric cancer with an intestinal phenotype
    Y Sanada
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, 734 8551, Japan
    J Pathol 208:633-42. 2006
    ..9%) (p = 0.0224). These results indicate that claudin-18 is a good marker of poor survival in GC. Down-regulation of claudin-18 may be involved in GCs with an intestinal phenotype, and may be an early event in gastric carcinogenesis...
  18. ncbi request reprint No mutations of the Bub1 gene in human gastric carcinomas
    H Shigeishi
    First Department of Pathology, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
    Oncol Rep 8:791-4. 2001
    ..These results suggest that mutational inactivation of the Bub1 gene might not play a key role in human stomach carcinogenesis...
  19. ncbi request reprint Promoter hypermethylation of MGMT is associated with protein loss in gastric carcinoma
    N Oue
    First Department of Pathology, Hiroshima University School of Medicine, Hiroshima, Japan
    Int J Cancer 93:805-9. 2001
    ..Our results suggest that transcriptional inactivation of MGMT by aberrant methylation of the promoter region may participate in carcinogenesis in the stomach...
  20. ncbi request reprint Clinicopathological significance of vascular endothelial growth factor (VEGF)-C in human esophageal squamous cell carcinomas
    Y Kitadai
    Department of Endoscopy, Hiroshima University School of Medicine, Hiroshima, Japan
    Int J Cancer 93:662-6. 2001
    ..These results overall suggest that VEGF-C may play a role in tumor progression via lymphangiogenesis and angiogenesis in human esophageal carcinoma...
  21. ncbi request reprint Acetylated histone H4 is reduced in human gastric adenomas and carcinomas
    S Ono
    Dept of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, Japan
    J Exp Clin Cancer Res 21:377-82. 2002
    ..These results suggest that low levels of histone acetylation may be closely associated with the development and progression of gastric carcinomas, possibly through alteration of gene expression...
  22. pmc Presence of vascular adventitial fibroblastic cells in diffuse-type gastric carcinomas
    H Nakayama
    Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Clin Pathol 57:970-2. 2004
    ....
  23. ncbi request reprint Alterations of p73 preferentially occur in gastric adenocarcinomas with foveolar epithelial phenotype
    H Yokozaki
    First Department of Pathology, Hiroshima University School of Medicine, Hiroshima, Japan
    Int J Cancer 83:192-6. 1999
    ..Our results suggest that alterations of p73, including LOH and abnormal expression, may play roles in the genesis of foveolar-type gastric adenocarcinomas, though this is not in line with a classical Knudson's "2-hit" model...
  24. ncbi request reprint Reg IV is a serum biomarker for gastric cancer patients and predicts response to 5-fluorouracil-based chemotherapy
    Y Mitani
    Department of Molecular Pathology, Hiroshima University, Graduate School of Biomedical Sciences, Hiroshima, Japan
    Oncogene 26:4383-93. 2007
    ..5%) or carbohydrate antigen 19-9 (13.1%). These results indicate that expression of Reg IV is a marker for prediction of resistance to 5-FU-based chemotherapy in patients with GC. Serum Reg IV represents a novel biomarker for GC...
  25. ncbi request reprint Systematic search for gastric cancer-specific genes based on SAGE data: melanoma inhibitory activity and matrix metalloproteinase-10 are novel prognostic factors in patients with gastric cancer
    P P Aung
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Oncogene 25:2546-57. 2006
    ..As expression of MIA and MMP-10 is narrowly restricted in cancer, these two molecules may be good therapeutic targets for GC...
  26. ncbi request reprint Microsatellite instability in squamous cell carcinomas and dysplasias of the esophagus
    Y Kagawa
    Department of Surgical Oncology, School of Medicine, Hiroshima University, Japan
    Anticancer Res 20:213-7. 2000
    ..Although the significance of MSI in esophageal carcinoma was not clear, these results indicate that MSI occurs in the early stage of esophageal carcinogenesis...
  27. doi request reprint Reg IV enhances peritoneal metastasis in gastric carcinomas
    H Kuniyasu
    Department of Molecular Pathology, Nara Medical University School of Medicine, Kashihara, Nara, Japan
    Cell Prolif 42:110-21. 2009
    ..The role of Regenerating (Reg) IV on peritoneal metastasis was examined in gastric cancer using...
  28. ncbi request reprint Expression of Bub1 gene correlates with tumor proliferating activity in human gastric carcinomas
    H Shigeishi
    First Department of Pathology, Hiroshima University School of Medicine, Hiroshima, Japan
    Pathobiology 69:24-9. 2001
    ....
  29. ncbi request reprint Expression of MRE11 complex (MRE11, RAD50, NBS1) and hRap1 and its relation with telomere regulation, telomerase activity in human gastric carcinomas
    N Matsutani
    First Department of Pathology, Hiroshima University School of Medicine, Minami Ku, Hiroshima, Japan
    Pathobiology 69:219-24. 2001
    ..05). These results suggest that gastric carcinomas with high TRF1 and TRF2 expression may need a large quantity of the MRE11 complex. Moreover, gastric carcinomas with high TRF1 expression may require a large quantity of hRap1...
  30. ncbi request reprint Reg IV expression is associated with cell growth and prognosis of adenoid cystic carcinoma in the salivary gland
    T Sasahira
    Department of Molecular Pathology, Nara Medical University, Kashihara, Nara, Japan
    Histopathology 53:667-75. 2008
    ..Regenerating islet-derived family, member 4 (Reg IV) is associated with the progression of various cancers. The aim was to examine Reg IV expression in adenoid cystic carcinomas (ACCs) in salivary glands...
  31. ncbi request reprint DNA demethylation of vascular endothelial growth factor-C is associated with gene expression and its possible involvement of lymphangiogenesis in gastric cancer
    Shunji Matsumura
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Int J Cancer 120:1689-95. 2007
    ..0001). These results suggest that demethylation and activation of the VEGF-C gene is likely involved in lymphangiogenesis in GC...
  32. ncbi request reprint Morphological changes in human gastric tumours after eradication therapy of Helicobacter pylori in a short-term follow-up
    M Ito
    Department of Medicine and Molecular Science, Hiroshima University, Hiroshima, Japan
    Aliment Pharmacol Ther 21:559-66. 2005
    ..It is controversial as to whether the development of gastric cancer is influenced by Helicobacter pylori eradication. If eradication itself influences the tumour morphology, this may affect the tumour discovery rate...
  33. ncbi request reprint Expression of integrin-linked kinase is closely correlated with invasion and metastasis of gastric carcinoma
    Reiko Ito
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Virchows Arch 442:118-23. 2003
    ..ILK might be a novel molecular marker for aggressive gastric cancer...
  34. ncbi request reprint Vascular endothelial growth factor-C expression predicts lymph node metastasis of human gastric carcinomas invading the submucosa
    T Amioka
    First Department of Internal Medicine, Hiroshima University School of Medicine, 1 2 3 Kasumi, Minami Ku, Japan
    Eur J Cancer 38:1413-9. 2002
    ..VEGF-C expression at the invading edge of a gastric carcinoma may be a sensitive marker for metastasis to the lymph nodes...
  35. ncbi request reprint Loss of heterozygosity and histone hypoacetylation of the PINX1 gene are associated with reduced expression in gastric carcinoma
    Tomohiro Kondo
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Oncogene 24:157-64. 2005
    ..These results indicate that LOH of PINX1 locus and hypoacetylation of histone H4 in the 5' UTR of PINX1 are associated with reduced expression of PINX1 in GC...
  36. ncbi request reprint Differential expression of claudin-2 in normal human tissues and gastrointestinal carcinomas
    Phyu Phyu Aung
    Department of Molecular Pathology, Graduate School of Biomedical Sciences Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, Japan
    Virchows Arch 448:428-34. 2006
    ..These results suggest that the expression of claudin-2 may involve organ specificity, and increased expression of claudin-2 may participate in colorectal carcinogenesis...
  37. doi request reprint Search for transmembrane protein in gastric cancer by the Escherichia coli ampicillin secretion trap: expression of DSC2 in gastric cancer with intestinal phenotype
    Katsuhiro Anami
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    J Pathol 221:275-84. 2010
    ..Our results provide a list of genes that have high potential as a diagnostic and therapeutic target for GC...
  38. ncbi request reprint DNA hypermethylation and histone hypoacetylation of the HLTF gene are associated with reduced expression in gastric carcinoma
    Yoichi Hamai
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Minami Ku, Hiroshima 734 8551, Japan
    Cancer Sci 94:692-8. 2003
    ..These results suggest that transcriptional inactivation of HLTF by aberrant DNA methylation and histone deacetylation may be involved in stomach carcinogenesis through down-regulation of HLTF expression...
  39. doi request reprint Vascular endothelial growth factor C stimulates progression of human gastric cancer via both autocrine and paracrine mechanisms
    Michiyo Kodama
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Clin Cancer Res 14:7205-14. 2008
    ..VEGFR-3 has also been detected on several malignant cells, but the significance of VEGFR-3 expression on malignant cells remains unclear. In this study, we examined the expression and function of VEGFR-3 in gastric carcinoma cells...
  40. ncbi request reprint Laminin gamma2 mediates Wnt5a-induced invasion of gastric cancer cells
    Hideki Yamamoto
    Department of Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Gastroenterology 137:242-52, 252.e1-6. 2009
    ..The aim of this study was to show that Wnt5a is involved in metastasis of gastric cancer cells in vivo and to explore the molecular mechanism by which Wnt5a regulates migration and invasion...
  41. ncbi request reprint Frequent loss of RUNX3 expression by promoter hypermethylation in gastric carcinoma
    Yasuhiro Oshimo
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Pathobiology 71:137-43. 2004
    ..Our results overall suggest that transcriptional inactivation of RUNX3 by promoter hypermethylation may participate in the stomach carcinogenesis...
  42. ncbi request reprint A single nucleotide polymorphism in the extracellular domain of TRAIL receptor DR4 at nucleotide 626 in gastric cancer patients in Japan
    Kazuya Kuraoka
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Oncol Rep 14:465-70. 2005
    ..In conclusion, a Thr to Arg single nucleotide polymorphism in the extracellular domain of DR4 could not be associated with the development and progression of gastric cancer...
  43. ncbi request reprint Histone H3 acetylation is associated with reduced p21(WAF1/CIP1) expression by gastric carcinoma
    Yoshitsugu Mitani
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    J Pathol 205:65-73. 2005
    ..These findings provide evidence that alteration of histone acetylation occurs in human cancer tissue specimens such as those from gastric carcinoma...
  44. ncbi request reprint Expression of Cbl linking with the epidermal growth factor receptor system is associated with tumor progression and poor prognosis of human gastric carcinoma
    Reiko Ito
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, 734 8551 Hiroshima, Japan
    Virchows Arch 444:324-31. 2004
    ..These results suggest that Cbl in connection with the EGFR system may be associated with stomach carcinogenesis, invasion and metastasis. Cbl may serve as a novel molecular marker for aggressive gastric carcinoma...
  45. ncbi request reprint DNA methylation of genes linked with retinoid signaling in gastric carcinoma: expression of the retinoid acid receptor beta, cellular retinol-binding protein 1, and tazarotene-induced gene 1 genes is associated with DNA methylation
    Mariko Shutoh
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Kasumi, Hiroshima, Japan
    Cancer 104:1609-19. 2005
    ..In this study, the authors investigated the methylation status of these genes and analyzed the role of their DNA methylation in GC...
  46. ncbi request reprint Genes involved in invasion and metastasis of gastric cancer identified by array-based hybridization and serial analysis of gene expression
    Naohide Oue
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Oncology 69:17-22. 2005
    ..We also discuss the significance of HMGB1/amphoterin in invasion and metastasis of GC...
  47. doi request reprint High mobility group box-1-inducible melanoma inhibitory activity is associated with nodal metastasis and lymphangiogenesis in oral squamous cell carcinoma
    Tomonori Sasahira
    Department of Molecular Pathology, Nara Medical University School of Medicine, Kashihara, Japan
    Cancer Sci 99:1806-12. 2008
    ..These results suggest that MIA expression is enhanced by the interaction of intracellular HMGB1 and NFkBp65 and MIA is closely involved in tumor progression and nodal metastasis by the increments of VEGF-C and VEGF-D in OSCC...
  48. doi request reprint Gene expression profiling with microarray and SAGE identifies PLUNC as a marker for hepatoid adenocarcinoma of the stomach
    Kazuhiro Sentani
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Mod Pathol 21:464-75. 2008
    ..These results indicate that PLUNC is a novel marker that distinguishes gastric hepatoid adenocarcinoma from primary hepatocellular carcinoma...
  49. ncbi request reprint Presence of perivenular elastic fibers in nonalcoholic steatohepatitis Fibrosis Stage III
    H Nakayama
    Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi, Minami Ku, Hiroshima, Japan
    Histol Histopathol 23:407-9. 2008
    ..In liver needle biopsy specimens of NASH, detection of perivenular elastic fibers is useful in deciding Fibrosis Stage III...
  50. ncbi request reprint Nuclear and mitochondrial DNA microsatellite instability in gastrointestinal stromal tumors
    K Kose
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Pathobiology 73:93-7. 2006
    ..Nuclear (nMSI) and mitochondrial microsatellite instability (mtMSI) play important roles in tumorigenesis in various organs. The aim of this study was to evaluate the role of nMSI and mtMSI in GISTs...
  51. pmc High molecular weight caldesmon positive stromal cells in the capsule of hepatocellular carcinomas
    H Nakayama
    Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi Minami ku, Hiroshima 734 8551, Japan
    J Clin Pathol 57:776-7. 2004
    ..To investigate the smooth muscle nature of the stromal cells in the capsule of hepatocellular carcinomas...
  52. ncbi request reprint DNA methylation of genes linked to retinoid signaling in squamous cell carcinoma of the esophagus: DNA methylation of CRBP1 and TIG1 is associated with tumor stage
    Hirozumi Mizuiri
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
    Cancer Sci 96:571-7. 2005
    ..These results show that inactivation of the retinoic acid signaling-associated genes RAR-beta, CRBP1, and TIG1 by DNA methylation occurs frequently in ESCC...
  53. doi request reprint Serum olfactomedin 4 (GW112, hGC-1) in combination with Reg IV is a highly sensitive biomarker for gastric cancer patients
    Naohide Oue
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Int J Cancer 125:2383-92. 2009
    ..These results suggest that serum olfactomedin 4 is a useful marker for GC and its measurement alone or in combination with Reg IV has utility in the early detection of GC...
  54. ncbi request reprint Melanoma-associated antigen-A1 expression predicts resistance to docetaxel and paclitaxel in advanced and recurrent gastric cancer
    Takahisa Suzuki
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734 8551, Japan
    Oncol Rep 18:329-36. 2007
    ..These results suggest that although MAGE-A1 does not participate directly in the drug-resistant phenotype, the expression of MAGE-A1 could be a marker for the prediction of resistance to taxan-based chemotherapies in patients with GC...
  55. ncbi request reprint Promoter methylation of cyclin D2 gene in gastric carcinoma
    Yasuhiro Oshimo
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8551, Japan
    Int J Oncol 23:1663-70. 2003
    ..These results suggest that DNA hypomethylation is a mechanism underlying the increased expression of cyclin D2 in cancer cells and that demethylation of cyclin D2 may be involved in development and progression of gastric carcinoma...
  56. ncbi request reprint Correlation of a single nucleotide polymorphism in the E-cadherin gene promoter with tumorigenesis and progression of gastric carcinoma in Japan
    Kazuya Kuraoka
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8551, Japan
    Int J Oncol 23:421-7. 2003
    ..05). These results suggest that the C/A SNP in the E-cadherin promoter may be a good marker for malignancy of gastric carcinomas...
  57. ncbi request reprint Protection of telomeres 1 protein levels are associated with telomere length in gastric cancer
    Kiyomu Fujii
    Department of Molecular Pathology, Nara Medical University School of Medicine, Kashihara, Nara, Japan
    Int J Mol Med 21:599-604. 2008
    ..05). Thus, Pot1 production was closely associated with telomere length in gastric mucosa and cancers. Pot1 might be a good in situ marker for the examination of cell-specific telomere length...
  58. ncbi request reprint Epigenetic inactivation of SOCS-1 by CpG island hypermethylation in human gastric carcinoma
    Yasuhiro Oshimo
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Int J Cancer 112:1003-9. 2004
    ..013 and 0.002, respectively). Our results suggest that transcriptional inactivation of the SOCS-1 gene by hypermethylation may be involved in development, progression and metastasis of GC...
  59. ncbi request reprint Expression of thrombospondin-1 is correlated with microvessel density in gastric carcinoma
    Jie Zhang
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 734 8551, Hiroshima, Japan
    Virchows Arch 442:563-8. 2003
    ..Our results support an idea that increased TSP-1 expression may be associated with an angiogenic phenotype in gastric carcinoma and suggest that TSP-1 may play diverse roles in each organ...
  60. ncbi request reprint Gene expression profile of gastric carcinoma: identification of genes and tags potentially involved in invasion, metastasis, and carcinogenesis by serial analysis of gene expression
    Naohide Oue
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Cancer Res 64:2397-405. 2004
    ..Our results provide a list of candidate genes that are potentially involved in invasion, metastasis, and carcinogenesis of GC. REGIV may serve as a specific biomarker for GC...
  61. doi request reprint Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase
    H Yamamoto
    Department of Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Oncogene 29:2036-46. 2010
    ..These results suggest that Wnt5a promotes the aggressiveness of prostate cancer and that its expression is involved in relapse after prostatectomy...
  62. pmc Adenocarcinoma arising from a gastric duplication cyst with invasion to the stomach: a case report with literature review
    K Kuraoka
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8551, Japan
    J Clin Pathol 57:428-31. 2004
    ..Duplication cysts should be included in the differential diagnosis of cystic masses of the gastrointestinal tract, and the possibility of malignancy within these cysts should be considered...
  63. pmc Lack of vascular adventitial fibroblastic cells in tumour stroma of intestinal-type and solid-type gastric carcinomas
    H Nakayama
    Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Clin Pathol 57:183-5. 2004
    ..To investigate the roles of vascular adventitial fibroblastic cells in tumour stroma, the distribution of vascular adventitial fibroblastic cells was studied in gastric carcinomas...
  64. ncbi request reprint Comparison of proliferative activity in coronary plaques from patients with coronary ischemia. Histopathological and immunohistochemical analysis
    H Ueda
    Second Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    Hiroshima J Med Sci 46:31-42. 1997
    ..Our findings suggest that the excessive proliferation of vascular wall cells, especially SMCs, is involved in the pathogenesis of ACS and in the process of wound repair after angioplasty in humans...
  65. ncbi request reprint Immunohistochemical analysis of hepatocyte growth factor in human coronary atherectomy specimens: comparison with transforming growth factor beta isoforms
    H Ueda
    Second Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    Virchows Arch 430:407-15. 1997
    ..These findings suggest that HGF produced by macrophages play a part in the process of coronary plaque formation attributable to thrombus in man...
  66. ncbi request reprint Molecular-pathological diagnosis of gastrointestinal tissues and its contribution to cancer histopathology
    W Yasui
    First Department of Pathology, Hiroshima University School of Medicine, Japan
    Pathol Int 49:763-74. 1999
    ..Molecular-pathological diagnosis thus contributes to detailed understanding of cancer histopathology and improves the histopathological diagnosis...
  67. ncbi request reprint Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human gastric carcinomas
    Masahiro Ohta
    Department of Medicine and Molecular Science, Hiroshima University, Hiroshima, Japan
    Int J Oncol 22:773-8. 2003
    ..These results suggest that MCP-1 produced by human gastric carcinoma cells plays a role in angiogenesis via macrophage recruitment and activation...
  68. doi request reprint Potential role for vascular endothelial growth factor-D as an autocrine factor for human gastric carcinoma cells
    Miwako Tanaka
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Cancer Sci 101:2121-7. 2010
    ..VEGF-D may participate in the progression of human gastric carcinoma by acting via autocrine and paracrine mechanisms...
  69. pmc Glycogen synthase kinase 3 and h-prune regulate cell migration by modulating focal adhesions
    Tsuyoshi Kobayashi
    Department of Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Mol Cell Biol 26:898-911. 2006
    ..These results suggest that GSK-3 and h-prune cooperatively regulate the disassembly of focal adhesions to promote cell migration and that h-prune is useful as a marker for tumor aggressiveness...
  70. ncbi request reprint Expression of RHOC is associated with metastasis of gastric carcinomas
    Tomohiro Kondo
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Pathobiology 71:19-25. 2004
    ..It has recently been reported that RHOC contributes to the metastatic phenotype of melanoma cells. The purpose of this study was to clarify its biological relevance to gastric carcinogenesis and metastasis...
  71. ncbi request reprint Helicobacter pylori infection influences expression of genes related to angiogenesis and invasion in human gastric carcinoma cells
    Yasuhiko Kitadai
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, 734 8551, Hiroshima, Japan
    Biochem Biophys Res Commun 311:809-14. 2003
    ..pylori. These results indicate that H. pylori infection may regulate angiogenesis and invasion of human gastric carcinoma...
  72. ncbi request reprint No mutations of the Bub1 gene in human gastric and oral cancer cell lines
    Hiroyuki Nakagawa
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Minami Ku, Hiroshima 734 8551, Japan
    Oncol Rep 9:1229-32. 2002
    ..These results suggest that mutation of the Bub1 gene might not play a role in human stomach and oral carcinogenesis...
  73. ncbi request reprint Induction of hRAD9 is required for G2/M checkpoint signal transduction in gastric cancer cells
    Ken Hayashi
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Pathobiology 70:40-6. 2002
    ..These results suggest that besides p53 activity, the induction of hRAD9 is required for G2/M checkpoint signal transduction in gastric cancer cells...
  74. ncbi request reprint Expression of osteoprotegerin correlates with aggressiveness and poor prognosis of gastric carcinoma
    Reiko Ito
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Japan
    Virchows Arch 443:146-51. 2003
    ..These results suggest that OPG may participate in stomach carcinogenesis, invasion and metastasis, and may serve as a novel molecular marker for aggressive gastric cancer...
  75. ncbi request reprint Expression and distribution of human telomerase catalytic component, hTERT, in human breast tissues
    Yasuo Yano
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1 2 3, Kasumi, Minami Ku, Hiroshima, 734 8553, Japan
    Anticancer Res 22:4101-7. 2002
    ..Activation of telomerase is essential in a variety of malignant tumors. However, the regulation of its activation and the expression of human telomerase reverse transcriptase (hTERT) are not fully understood in breast tissues...
  76. ncbi request reprint Induction mechanism of apoptosis by troglitazone through peroxisome proliferator-activated receptor-gamma in gastric carcinoma cells
    Kazuhiro Yoshida
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, School of Medicine, Hiroshima University, Hiroshima, Japan
    Anticancer Res 23:267-73. 2003
    ..It has been reported recently that the antidiabetic thiazolidinediones not only induce fibroblast differentiation but also inhibit the growth of carcinoma cells...
  77. ncbi request reprint Quantitative analysis of lymphangiogenic markers for predicting metastasis of human gastric carcinoma to lymph nodes
    Yasuhiko Kitadai
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Int J Cancer 115:388-92. 2005
    ..These results indicate that quantitative analysis of lymphangiogenic markers in gastric biopsy specimens may be useful in predicting metastasis of gastric cancer to regional lymph nodes...
  78. ncbi request reprint Loss of maspin expression is associated with development and progression of gastric carcinoma with p53 abnormality
    Reiko Ito
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Oncol Rep 12:985-90. 2004
    ..Loss of maspin expression may serve as a biological marker of high-grade malignancy...
  79. ncbi request reprint Cyclin D1 overexpression is not a specific grouping marker, but may collaborate with CDC37 in myeloma cells
    Yuta Katayama
    Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan
    Int J Oncol 25:579-95. 2004
    ..The CDC37 may collaborate with cyclin D1 in progression of MM...
  80. ncbi request reprint DNA methylation profiles of differentiated-type gastric carcinomas with distinct mucin phenotypes
    Junichi Motoshita
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Cancer Sci 96:474-9. 2005
    ..These results indicate that DNA methylation of specific genes, such as hMLH1 and MGMT, may be involved partly in the distinct phenotypic expression of GC...
  81. ncbi request reprint Chromosomal and microsatellite instability in sporadic gastric cancer
    Toru Hiyama
    Health Service Center, Hiroshima University, Higashihiroshima, Japan
    J Gastroenterol Hepatol 19:756-60. 2004
    ..It is hypothesized that these two pathways are not always independent and that some tumors show overlap between these two mechanisms...
  82. ncbi request reprint A single nucleotide polymorphism in the MMP-9 promoter affects tumor progression and invasive phenotype of gastric cancer
    Shunji Matsumura
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, 734 8551, Hiroshima, Japan
    J Cancer Res Clin Oncol 131:19-25. 2005
    ..The purpose of this study was to investigate the relation between the -1562 C/T polymorphism and the development and progression of gastric cancer...
  83. ncbi request reprint A single nucleotide polymorphism in the MMP-1 promoter is correlated with histological differentiation of gastric cancer
    Shunji Matsumura
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima, Japan
    J Cancer Res Clin Oncol 130:259-65. 2004
    ..In the light of these findings, we investigated whether this SNP in the MMP-1 promoter is associated with the development, differentiation, and progression of gastric cancer...
  84. ncbi request reprint Promoter methylation status of the DNA repair genes hMLH1 and MGMT in gastric carcinoma and metaplastic mucosa
    N Oue
    First Department of Pathology, Hiroshima University School of Medicine, Hiroshima, Japan
    Pathobiology 69:143-9. 2001
    ..Our results suggest that at least two types of promoter methylation participate in the development of gastric carcinoma. Tumor-specific promoter hypermethylation of hMLH1 may be an early event in carcinogenesis in the stomach...
  85. ncbi request reprint Distinct promoter hypermethylation of p16INK4a, CDH1, and RAR-beta in intestinal, diffuse-adherent, and diffuse-scattered type gastric carcinomas
    Naohide Oue
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    J Pathol 198:55-9. 2002
    ....
  86. ncbi request reprint Frequent epigenetic inactivation of RIZ1 by promoter hypermethylation in human gastric carcinoma
    Yasuhiro Oshimo
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Int J Cancer 110:212-8. 2004
    ..Our results suggest that transcriptional inactivation of the RIZ1 gene by promoter hypermethylation may participate in stomach carcinogenesis...
  87. ncbi request reprint A possible role for the loss of CD27-CD70 interaction in myelomagenesis
    Yuta Katayama
    Department of Haematology and Oncology, Division of Clinical Research, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan
    Br J Haematol 120:223-34. 2003
    ..These findings show that the relationship between the loss of CD27 and oncogenesis of plasma cells is not simple. It remains unclear whether the lack of CD27 leads to evasion of apoptosis...
  88. ncbi request reprint Clinicopathologic and genetic characteristics of gastric cancer in young male and female patients
    Shogo Sasao
    Department of Medicine and Molecular Science Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Minami Ku, Hiroshima 734 8551, Japan
    Oncol Rep 16:11-5. 2006
    ..9%, P = 0.046, 5% vs. 30%, P = 0.010, respectively). These results suggest that the pathways of gastric carcinogenesis differ between young patients and older patients, and that the pathways differ between the sexes in young patients...
  89. ncbi request reprint Hypoxia-inducible factor-1alpha polymorphisms associated with enhanced transactivation capacity, implying clinical significance
    Keiji Tanimoto
    Department of Translational Cancer Research, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734 8553, Japan
    Carcinogenesis 24:1779-83. 2003
    ..The elevated transactivation capacity of variant forms of HIF-1alpha implies a role of HIF-1alpha polymorphisms in generating individually different tumor progression...
  90. ncbi request reprint Accumulation of DNA methylation is associated with tumor stage in gastric cancer
    Naohide Oue
    Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1 2 3, Minami Ku, Hiroshima 734 8551, Japan
    Cancer 106:1250-9. 2006
    ....
  91. ncbi request reprint A single nucleotide polymorphism in the 5' untranslated region of the EGF gene is associated with occurrence and malignant progression of gastric cancer
    Yoichi Hamai
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Pathobiology 72:133-8. 2005
    ..We examined whether this polymorphism is correlated with the development and malignant phenotypes of gastric cancer...
  92. ncbi request reprint A single nucleotide polymorphism in the transmembrane domain coding region of HER-2 is associated with development and malignant phenotype of gastric cancer
    Kazuya Kuraoka
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Int J Cancer 107:593-6. 2003
    ..The association of HER-2 genotype with clinicopathologic characteristics of gastric cancer was also suggested, which has to be confirmed with a larger sample size...
  93. ncbi request reprint Molecular-pathological prognostic factors of gastric cancer: a review
    Wataru Yasui
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Gastric Cancer 8:86-94. 2005
    ..A combination of these examinations can not only foretell a patient's prognosis but can also give information directly connected with personalized cancer medicine and prevention...
  94. ncbi request reprint DNA methylation of CHFR is not a predictor of the response to docetaxel and paclitaxel in advanced and recurrent gastric cancer
    Kazuhiro Yoshida
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
    Anticancer Res 26:49-54. 2006
    ..In this study, the question of whether DNA methylation of CHFR, a mitotic checkpoint gene, can predict the response of advanced and recurrent gastric cancers (GCs) to docetaxel or paclitaxel was examined...
  95. ncbi request reprint Single nucleotide polymorphism in the hypoxia-inducible factor-1alpha gene in colorectal carcinoma
    Toshio Kuwai
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Hiroshima 734 8551, Japan
    Oncol Rep 12:1033-7. 2004
    ..0005). These results suggest that the C1772T polymorphism in HIF-1alpha is not involved in progression or metastasis of colorectal carcinoma...
  96. ncbi request reprint BRAF/K-ras mutation, microsatellite instability, and promoter hypermethylation of hMLH1/MGMT in human gastric carcinomas
    Ming Wu
    Division of Surgical Pathology, Department of Biomedical Informatics, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Gastric Cancer 7:246-53. 2004
    ....
  97. ncbi request reprint Expression of receptors for advanced glycation end-products (RAGE) is closely associated with the invasive and metastatic activity of gastric cancer
    Hiroki Kuniyasu
    Department of Oncological Pathology, Cancer Center, Nara Medical University, Kashihara, Japan
    J Pathol 196:163-70. 2002
    ..RAGE expression appears to be closely associated with invasion and metastasis in gastric cancer...
  98. ncbi request reprint ADAM8 as a novel serological and histochemical marker for lung cancer
    Nobuhisa Ishikawa
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Clin Cancer Res 10:8363-70. 2004
    ..Serum ADAM8 levels of 105 lung cancer patients and 72 controls were also measured by ELISA. A role of ADAM8 in cellular motility was examined by Matrigel assays...
  99. ncbi request reprint Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human esophageal squamous cell carcinomas
    Masahiro Ohta
    Department of Medicine and Molecular Science, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Int J Cancer 102:220-4. 2002
    ..These results suggest that interactions between cancer cells and macrophages are important for tumor angiogenesis. MCP-1 may play a role in progression of human esophageal carcinoma through its role in angiogenesis...
  100. ncbi request reprint Expression of thymidylate synthase, thymidine phosphorylase, dihydropyrimidine dehydrogenase, E2F-1, Bak, Bcl-X, and Bcl-2, and clinical outcomes for gastric cancer patients treated with bolus 5-fluorouracil
    Makoto Tahara
    Division of Digestive Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital East NCCHE, Chiba 277 8577, Japan
    Oncol Rep 11:9-15. 2004
    ..Furthermore, both Bcl-X expression and the coupled expression of Bak and Bcl-X, as well as histological type, may be useful predictive markers for survival...
  101. ncbi request reprint [Molecular-pathological diagnosis of gastric cancer]
    Wataru Yasui
    Dept of Molecular Pathology, Hiroshima University School of Biomedical Sciences, Japan
    Gan To Kagaku Ryoho 32:427-31. 2005
    ..Combined analyses of gene expression profile and genetic polymorphism will enable the characterization of the individual cancer and person, that is directly connected with personalized medicine and cancer prevention...