Shinji Tanaka

Summary

Affiliation: Hiroshima University
Country: Japan

Publications

  1. pmc Endoscopic assessment of colorectal cancer with superficial or deep submucosal invasion using magnifying colonoscopy
    Shinji Tanaka
    Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan
    Clin Endosc 46:138-46. 2013
  2. pmc Long-term Ultrasonographic Follow-up Study of Gastric Motility in Patients with Functional Dyspepsia
    Daisuke Kamino
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734 8551, Japan
    J Clin Biochem Nutr 42:144-9. 2008
  3. ncbi request reprint Determining depth of invasion by VN pit pattern analysis in submucosal colorectal carcinoma
    Shinji Tanaka
    Department of Endoscopy, Hiroshima University Medical Hospital, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Oncol Rep 9:1005-8. 2002
  4. ncbi request reprint Gastrointestinal stromal tumor in jejunum: diagnosis using contrast-enhanced ultrasonography and double-balloon enteroscopy
    Kayoko Kunihiro
    Department of Endoscopy, Hiroshima University Hospital, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734, Japan
    Dig Dis Sci 51:1236-40. 2006
  5. ncbi request reprint Effects of aged garlic extract (AGE) on colorectal adenomas: a double-blinded study
    Shinji Tanaka
    Department of Endoscopy, Hiroshima University Hospital, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8551, Japan
    Hiroshima J Med Sci 53:39-45. 2004
  6. doi request reprint Knack and practical technique of colonoscopic treatment focused on endoscopic mucosal resection using snare
    Shinji Tanaka
    Department of Endoscopy, Hiroshima University, Japan
    Dig Endosc 21:S38-42. 2009
  7. doi request reprint Multicenter questionnaire survey on the current situation of colorectal endoscopic submucosal dissection in Japan
    Shinji Tanaka
    Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan
    Dig Endosc 22:S2-8. 2010
  8. doi request reprint Aim to unify the narrow band imaging (NBI) magnifying classification for colorectal tumors: current status in Japan from a summary of the consensus symposium in the 79th Annual Meeting of the Japan Gastroenterological Endoscopy Society
    Shinji Tanaka
    Department of Endoscopy, Hiroshima University Hospital, Hiroshima University, Minami Ku, Hiroshima, Japan
    Dig Endosc 23:131-9. 2011
  9. ncbi request reprint Aged garlic extract has potential suppressive effect on colorectal adenomas in humans
    Shinji Tanaka
    Department of Endoscopy, Hiroshima University Hospital, Japan
    J Nutr 136:821S-826S. 2006
  10. doi request reprint Current status and future perspectives of endoscopic submucosal dissection for colorectal tumors
    Shinji Tanaka
    Department of Endoscopy Gastroenterology, Hiroshima University Hospital, Hiroshima, Japan
    Dig Endosc 24:73-9. 2012

Collaborators

Detail Information

Publications70

  1. pmc Endoscopic assessment of colorectal cancer with superficial or deep submucosal invasion using magnifying colonoscopy
    Shinji Tanaka
    Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan
    Clin Endosc 46:138-46. 2013
    ..We have to use pit pattern diagnosis and NBI magnifying diagnosis as the situation demands with the knowledge of both advantage and disadvantage in each diagnostic method...
  2. pmc Long-term Ultrasonographic Follow-up Study of Gastric Motility in Patients with Functional Dyspepsia
    Daisuke Kamino
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734 8551, Japan
    J Clin Biochem Nutr 42:144-9. 2008
    ..Gastric motility improved in group A but not in group B. In conclusion, improved gastric motility appears to correspond to and may explain improved symptoms in some patients with functional dyspepsia...
  3. ncbi request reprint Determining depth of invasion by VN pit pattern analysis in submucosal colorectal carcinoma
    Shinji Tanaka
    Department of Endoscopy, Hiroshima University Medical Hospital, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Oncol Rep 9:1005-8. 2002
    ..In submucosal colorectal carcinoma of the superficial or broad based sessile polypoid type in gross appearance, measurement of the maximum VN pit-pattern area diameter allows estimation of the depth of submucosal invasion...
  4. ncbi request reprint Gastrointestinal stromal tumor in jejunum: diagnosis using contrast-enhanced ultrasonography and double-balloon enteroscopy
    Kayoko Kunihiro
    Department of Endoscopy, Hiroshima University Hospital, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734, Japan
    Dig Dis Sci 51:1236-40. 2006
  5. ncbi request reprint Effects of aged garlic extract (AGE) on colorectal adenomas: a double-blinded study
    Shinji Tanaka
    Department of Endoscopy, Hiroshima University Hospital, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8551, Japan
    Hiroshima J Med Sci 53:39-45. 2004
    ..03). The results of this study suggest the possibility of preventive and therapeutic effects of AGE on colorectal adenomas, though it is necessary to investigate these in larger-scale and longer-term trials...
  6. doi request reprint Knack and practical technique of colonoscopic treatment focused on endoscopic mucosal resection using snare
    Shinji Tanaka
    Department of Endoscopy, Hiroshima University, Japan
    Dig Endosc 21:S38-42. 2009
    ..We can and should differentiate EMR from endoscopic submucosal dissection (ESD) for various types of colorectal tumor according to detailed endoscopic diagnosis using magnification prior to treatment...
  7. doi request reprint Multicenter questionnaire survey on the current situation of colorectal endoscopic submucosal dissection in Japan
    Shinji Tanaka
    Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan
    Dig Endosc 22:S2-8. 2010
    ..The average time required for colorectal ESD was 92.2 min, the rate of complete en bloc resection was 83.8%, the perforation rate was 4.8%, and no case of death from complications was reported...
  8. doi request reprint Aim to unify the narrow band imaging (NBI) magnifying classification for colorectal tumors: current status in Japan from a summary of the consensus symposium in the 79th Annual Meeting of the Japan Gastroenterological Endoscopy Society
    Shinji Tanaka
    Department of Endoscopy, Hiroshima University Hospital, Hiroshima University, Minami Ku, Hiroshima, Japan
    Dig Endosc 23:131-9. 2011
    ..Of course the NICE classification can be used more precisely with magnification. In this report we also refer the issues on NBI magnification, which should be solved as early as possible...
  9. ncbi request reprint Aged garlic extract has potential suppressive effect on colorectal adenomas in humans
    Shinji Tanaka
    Department of Endoscopy, Hiroshima University Hospital, Japan
    J Nutr 136:821S-826S. 2006
    ..04). The results suggest AGE suppresses progression of colorectal adenomas in humans. It appears that AGE has multiple pathways to reduce cancer incidence and suppress its growth and proliferation...
  10. doi request reprint Current status and future perspectives of endoscopic submucosal dissection for colorectal tumors
    Shinji Tanaka
    Department of Endoscopy Gastroenterology, Hiroshima University Hospital, Hiroshima, Japan
    Dig Endosc 24:73-9. 2012
    ..In the near future, colorectal ESD will be a common therapeutic method for early colorectal carcinoma...
  11. pmc Warning for unprincipled colorectal endoscopic submucosal dissection: accurate diagnosis and reasonable treatment strategy
    Shinji Tanaka
    Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan
    Dig Endosc 25:107-16. 2013
    ....
  12. pmc Small bowel abnormalities in patients with compensated liver cirrhosis
    Taiki Aoyama
    Department of Gastroenterology and Metabolism, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8551, Japan
    Dig Dis Sci 58:1390-6. 2013
    ....
  13. pmc Effectiveness of polaprezinc for low-dose aspirin-induced small-bowel mucosal injuries as evaluated by capsule endoscopy: a pilot randomized controlled study
    Ikue Watari
    Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
    BMC Gastroenterol 13:108. 2013
    ..Polaprezinc, a chelate of zinc and L-carnosine, may be efficacious for such injury. We conducted a pilot randomized controlled study to investigate whether polaprezinc is effective against LDA-induced small-bowel injuries...
  14. doi request reprint Antibodies to Helicobacter pylori and CagA protein are associated with the response to antibacterial therapy in patients with H. pylori-positive API2-MALT1-negative gastric MALT lymphoma
    Tomonori Sumida
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Cancer Sci 100:1075-81. 2009
    ..In conclusion, measurement of titers of serum antibodies to H. pylori and CagA protein may be useful for predicting the response to eradication therapy in patients with H. pylori-positive API2-MALT1-negative gastric MALT lymphoma...
  15. ncbi request reprint Expression of hypoxia-inducible factor-1alpha is associated with tumor vascularization in human colorectal carcinoma
    Toshio Kuwai
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Int J Cancer 105:176-81. 2003
    ..These findings suggest that HIF-1alpha may play a role in angiogenesis and tumor progression via regulation of VEGF in human colorectal carcinoma...
  16. doi request reprint Vascular endothelial growth factor C stimulates progression of human gastric cancer via both autocrine and paracrine mechanisms
    Michiyo Kodama
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Clin Cancer Res 14:7205-14. 2008
    ..VEGFR-3 has also been detected on several malignant cells, but the significance of VEGFR-3 expression on malignant cells remains unclear. In this study, we examined the expression and function of VEGFR-3 in gastric carcinoma cells...
  17. ncbi request reprint Expression of vascular endothelial growth factor and angiogenesis in gastrointestinal stromal tumor of the stomach
    Ryoji Takahashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Oncology 64:266-74. 2003
    ..The aim of this study was to elucidate the clinical significance of VEGF expression in gastrointestinal stromal tumor (GIST)...
  18. doi request reprint Anti-stromal therapy with imatinib inhibits growth and metastasis of gastric carcinoma in an orthotopic nude mouse model
    Tomonori Sumida
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Minami Ku, Hiroshima, Japan
    Int J Cancer 128:2050-62. 2011
    ..In conclusion, administration of PDGF-R tyrosine kinase inhibitor in combination with irinotecan appears to impair the progressive growth of gastric carcinoma by blockade of PDGF-R signaling pathways in stromal cells...
  19. doi request reprint Stroma-directed imatinib therapy impairs the tumor-promoting effect of bone marrow-derived mesenchymal stem cells in an orthotopic transplantation model of colon cancer
    Kei Shinagawa
    Department of Gastroenterology and Metabolism, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Int J Cancer 132:813-23. 2013
    ..Our data suggest that blockade of PDGF signaling pathways influences the interaction between bone marrow-derived MSCs and tumor cells in the tumor microenvironment and, hence, inhibits the progressive growth of colon cancer...
  20. ncbi request reprint Genetic and pathologic characteristics of gastrointestinal stromal tumors in extragastric lesions
    Songde Cho
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8551, Japan
    Int J Mol Med 18:1067-71. 2006
    ..These data suggest that extragastric GISTs differ from gastric GISTs with respect to associated mutations and angiogenic activity...
  21. doi request reprint Relationship between Helicobacter pylori tyrosine-phosphorylated CagA-related markers and the development of diffuse-type gastric cancers: a case-control study
    Yoshihiro Wada
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Digestion 82:10-7. 2010
    ..Diffuse-type gastric cancer (DGC) has a poor prognosis. We tried to clarify the expression level of CagA-P in DGC patients...
  22. ncbi request reprint Single nucleotide polymorphism in the hypoxia-inducible factor-1alpha gene in colorectal carcinoma
    Toshio Kuwai
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Hiroshima 734 8551, Japan
    Oncol Rep 12:1033-7. 2004
    ..0005). These results suggest that the C1772T polymorphism in HIF-1alpha is not involved in progression or metastasis of colorectal carcinoma...
  23. doi request reprint Relation between histologic gastritis and gastric motility in Japanese patients with functional dyspepsia: evaluation by transabdominal ultrasonography
    Yoshiaki Matsumoto
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Gastroenterol 43:332-7. 2008
    ..Few reports discuss gastric motility in relation to histologic gastritis. We examined the relation between gastric motility and histologic gastritis in Japanese patients with FD...
  24. ncbi request reprint Monocyte chemoattractant protein-1 transfection induces angiogenesis and tumorigenesis of gastric carcinoma in nude mice via macrophage recruitment
    Tsuyoshi Kuroda
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences and Health Service Center, Hiroshima University, Japan
    Clin Cancer Res 11:7629-36. 2005
    ..The present study was undertaken to obtain direct evidence that MCP-1 participates in recruitment of macrophages and induction of angiogenesis...
  25. ncbi request reprint Presence of poorly differentiated component correlated with submucosal invasion in the early diffuse-type gastric cancer
    Tsuyoshi Kuroda
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Hepatogastroenterology 55:2264-8. 2008
    ..The aim of this study is to distinguish the behaviors of early diffuse-type gastric carcinomas by sub classifying tumors according to their histologic features...
  26. ncbi request reprint Role of Helicobacter pylori infection and chronic inflammation in gastric cancer in the cardia
    Yasuo Egi
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Jpn J Clin Oncol 37:365-9. 2007
    ..Recently, we reported that H. pylori is an important factor for the induction of cardiac inflammation. We examined the status of H. pylori-induced gastritis in patients with cardiac cancer...
  27. doi request reprint Potential role for vascular endothelial growth factor-D as an autocrine factor for human gastric carcinoma cells
    Miwako Tanaka
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Cancer Sci 101:2121-7. 2010
    ..VEGF-D may participate in the progression of human gastric carcinoma by acting via autocrine and paracrine mechanisms...
  28. ncbi request reprint Expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in early gastric carcinoma: correlation with clinicopathological parameters
    Seiji Onogawa
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Cancer Lett 226:85-90. 2005
    ..No association was identified between VEGF-D immunoreactivity and clinicopathological variables. These results suggest that VEGF-C is a dominant regulator of lymphangiogenesis in early-stage human gastric carcinoma...
  29. ncbi request reprint Clinical significance of angiopoietin-2 expression at the deepest invasive tumor site of advanced colorectal carcinoma
    Takehiko Ochiumi
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biochemical Research, Graduated School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Int J Oncol 24:539-47. 2004
    ....
  30. ncbi request reprint Clinical significance of thrombospondin-1 expression in relation to vascular endothelial growth factor and interleukin-10 expression at the deepest invasive tumor site of advanced colorectal carcinoma
    Eijiro Kaio
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biochemical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Int J Oncol 23:901-11. 2003
    ..Although lack of TSP-1 or IL-10 expression was associated significantly with poorer prognosis, this may be less important in poorer prognosis than the presence of VEGF expression...
  31. ncbi request reprint Evaluation of gastric cancer risk using topography of histological gastritis: a large-scaled cross-sectional study
    Shinobu Imagawa
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi Minami ku, Hiroshima 734 8551, Japan
    Dig Dis Sci 53:1818-23. 2008
    ..3 and 54.7%, which were superior to the serum criteria using pepsinogens. These suggest that topography of histologic gastritis is an important marker to identify the high-risk group...
  32. doi request reprint Serum olfactomedin 4 (GW112, hGC-1) in combination with Reg IV is a highly sensitive biomarker for gastric cancer patients
    Naohide Oue
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Int J Cancer 125:2383-92. 2009
    ..These results suggest that serum olfactomedin 4 is a useful marker for GC and its measurement alone or in combination with Reg IV has utility in the early detection of GC...
  33. ncbi request reprint Frequent loss of heterozygosity on chromosome 10p14-p15 in esophageal dysplasia and squamous cell carcinoma
    Hideyuki Shima
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Program for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Minami Ku, Hiroshima 734 8551, Japan
    Oncol Rep 12:333-7. 2004
    ..These data suggest that a putative tumor suppressor gene for esophageal carcinogenesis may be located on chromosome 10p14-p15 and that malfunction of this gene may be involved in the development but not progression of esophageal tumors...
  34. ncbi request reprint Little necessity of acid inhibition against proton pump inhibitor rebound effects and prior helicobacter pylori eradication therapy in gastric ulcer patients: a randomized prospective study
    Yoshihiro Wada
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Hepatogastroenterology 56:624-8. 2009
    ..Rebound acid hypersecretion develops after the use of proton pump inhibitors (PPI). We examined the clinical necessity of acid inhibitors to prevent GERD or RE caused by PPI rebound phenomenon and prior H. pylori eradication therapy...
  35. doi request reprint Computer-aided system for predicting the histology of colorectal tumors by using narrow-band imaging magnifying colonoscopy (with video)
    Yoshito Takemura
    Department of Medicine and Molecular Science, Hiroshima University, Hiroshima, Japan
    Gastrointest Endosc 75:179-85. 2012
    ..Accurate NBI-based diagnosis requires training and experience. In addition, objective diagnosis is necessary. Thus, we developed a computerized system to automatically classify NBI magnifying colonoscopic images...
  36. ncbi request reprint Deletion of the KIT gene is associated with liver metastasis and poor prognosis in patients with gastrointestinal stromal tumor in the stomach
    Songde Cho
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Minami Ku, Hiroshima 734 8551, Japan
    Int J Oncol 28:1361-7. 2006
    ..Our data indicate that KIT mutations, especially deletions in exon 11, are markers of poor prognosis for gastric GISTs...
  37. ncbi request reprint Nodular gastritis in adults is caused by Helicobacter pylori infection
    Masaki Miyamoto
    First Department of Internal Medicine, Hiroshima University School of Medicine, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Dig Dis Sci 48:968-75. 2003
    ..Helicobacter pylori eradication decreases symptoms and reduces the risk of peptic ulcers and possibly gastric cancer...
  38. ncbi request reprint Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human gastric carcinomas
    Masahiro Ohta
    Department of Medicine and Molecular Science, Hiroshima University, Hiroshima, Japan
    Int J Oncol 22:773-8. 2003
    ..These results suggest that MCP-1 produced by human gastric carcinoma cells plays a role in angiogenesis via macrophage recruitment and activation...
  39. ncbi request reprint Expression of hypoxia-inducible factor (HIF)-1alpha is associated with vascular endothelial growth factor expression and tumour angiogenesis in human oesophageal squamous cell carcinoma
    Shigeru Kimura
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Eur J Cancer 40:1904-12. 2004
    ..These results suggest that HIF-1alpha and VEGF expression are important determinants of survival in squamous cell carcinoma of the oesophagus...
  40. doi request reprint Risk factors for vertical incomplete resection in endoscopic submucosal dissection as total excisional biopsy for submucosal invasive colorectal carcinoma
    Shun Ichiro Ozawa
    Department of Endoscopy, Hiroshima University Hospital, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8551, Japan
    Int J Colorectal Dis 28:1247-56. 2013
    ..This study aimed to identify risk factors for vertical incomplete resection (vertical margin-positive [VM+]) when ESD was performed as total excisional biopsy for SMca...
  41. doi request reprint Quantitative identification of mucosal gastric cancer under magnifying endoscopy with flexible spectral imaging color enhancement
    Rie Miyaki
    Departments of Gastroenterology and Metabolism, Hiroshima University, Hiroshima, Japan
    J Gastroenterol Hepatol 28:841-7. 2013
    ..Accurate FICE-based diagnosis requires training and experience. In addition, objectivity is necessary. Thus, a software program that can identify gastric cancer quantitatively was developed...
  42. ncbi request reprint Hypoxia-inducible factor-1alpha expression and angiogenesis in gastrointestinal stromal tumor of the stomach
    Ryoji Takahashi
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan
    Oncol Rep 10:797-802. 2003
    ..HIF-1alpha may play a role in angiogenesis and tumor progression of GIST through regulation of VEGF...
  43. doi request reprint Clinical validity of endoscopic submucosal dissection for submucosal invasive gastric cancer: a single-center study
    Yoji Sanomura
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Science, 1 2 3 Kasumi, Minami Ku, Hiroshima, Japan
    Gastric Cancer 15:97-105. 2012
    ..Our purpose in this study was to confirm the validity of the expanded indications for curative endoscopic submucosal dissection (ESD) of SM-GC...
  44. ncbi request reprint Quantitative analysis of lymphangiogenic markers for predicting metastasis of human gastric carcinoma to lymph nodes
    Yasuhiko Kitadai
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Int J Cancer 115:388-92. 2005
    ..These results indicate that quantitative analysis of lymphangiogenic markers in gastric biopsy specimens may be useful in predicting metastasis of gastric cancer to regional lymph nodes...
  45. ncbi request reprint Treatment of functional dyspepsia with serotonin agonists: a meta-analysis of randomized controlled trials
    Toru Hiyama
    Health Service Center, Hiroshima University, Higashihiroshima, Japan
    J Gastroenterol Hepatol 22:1566-70. 2007
    ..The aim of this study was to perform a meta-analysis of randomized controlled trials (RCTs) comparing serotonin agonists with other types of prokinetics in patients with FD...
  46. ncbi request reprint Clinical significance of angiogenic factor expression at the deepest invasive site of advanced colorectal carcinoma
    Eijiro Kaio
    The First Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima, Japan
    Oncology 64:61-73. 2003
    ..Of the several angiogenic factors, VEGF expression at the deepest invasive site of tumor was the most statistically significant indicator of prognosis in advanced CRC...
  47. doi request reprint Management of T1 colorectal carcinoma with special reference to criteria for curative endoscopic resection
    Koichi Nakadoi
    Department of Gastroenterology and Metabolism, Graduate School of Biochemical Sciences, Hiroshima University, Hiroshima, Japan
    J Gastroenterol Hepatol 27:1057-62. 2012
    ..We aimed to expand these criteria...
  48. doi request reprint High expression of gastrin receptor protein in injured mucosa of Helicobacter pylori-positive gastritis
    Akemi Takamura
    Department of Gastroenterology and Metabolism, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8551, Japan
    Dig Dis Sci 58:634-40. 2013
    ..However, it is unknown how gastric receptor (GR) expression is regulated in the gastric mucosa. We studied GR expression using a newly raised antibody and investigated the relationship between GR expression and gastritis...
  49. ncbi request reprint Helicobacter pylori cagA polymorphism and gastric inflammation: an international comparison between Japanese and Brazilian patients
    Akemi Takamura
    Department of Medicine and Molecular Science, Hiroshima University, Hiroshima, Japan
    Scand J Gastroenterol 46:1051-6. 2011
    ..pylori cytotoxin associated gene A (cagA) is considered to be an important factor for its development. We investigated the relationship between the grades of gastritis and cagA phenotype in Japanese and Brazilian patients...
  50. ncbi request reprint Clinical significance of Fhit expression in development of colorectal carcinoma of various macroscopic types
    Toshio Kuwai
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Hiroshima University, Graduate School of Biomedical Sciences, Hiroshima, Japan
    Int J Mol Med 12:437-42. 2003
    ..01). The present findings suggest that reduced expression of Fhit protein is related to development of colorectal neoplasm. Polypoid CRC and G-LST appear to differ from superficial depressed CRC in terms of Fhit expression...
  51. ncbi request reprint Somatic mutation of mitochondrial DNA in Helicobacter pylori-associated chronic gastritis in patients with and without gastric cancer
    Toru Hiyama
    Health Service Center, Hiroshima University, Higashihiroshima 739 8521, Japan
    Int J Mol Med 12:169-74. 2003
    ..4%, p<0.001). These data suggest that somatic mutations of the mtDNA may be involved in the early stages of gastric carcinogenesis...
  52. doi request reprint Evaluation and validation of computed virtual chromoendoscopy in early gastric cancer
    Ritsuo Mouri
    Program for Biomedical Research, Hiroshima University Hospital, Japan
    Gastrointest Endosc 69:1052-8. 2009
    ..The aim of this study was to investigate the usefulness of FICE with a specific wavelength in the assessment of early gastric cancers (EGCs), and the relationship between the FICE visualization and blood vessels...
  53. ncbi request reprint Somatic mutation in mitochondrial DNA and nuclear microsatellite instability in gastric cancer
    Toru Hiyama
    Health Service Center, Hiroshima University, Higashihiroshima 739 8521, Japan
    Oncol Rep 10:1837-41. 2003
    ..These results suggest that somatic mutations in the mtDNA and nuclear MSI-H play important roles in gastric carcinogenesis, and that mtDNA mutations may not be associated with nuclear MSI-H in gastric cancers...
  54. ncbi request reprint Magnifying endoscopy with narrow band imaging for diagnosis of colorectal tumors
    Mayuko Hirata
    Department of Medicine and Molecular Science, Graduate School of Biomedical Science, Health Service Center, Hiroshima University, Hiroshima, Japan
    Gastrointest Endosc 65:988-95. 2007
    ..Narrow band imaging (NBI) uses optical filters for red-green-blue sequential illumination and narrows the bandwidth of spectral transmittance...
  55. ncbi request reprint Expression of p53 protein in esophageal squamous cell carcinoma: relation to hypoxia-inducible factor-1alpha, angiogenesis and apoptosis
    Shigeru Kimura
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Pathobiology 72:179-85. 2005
    ..p53 has been reported to interact with HIF-1alpha and induce ubiquitin-mediated proteosomal degradation of HIF-1alpha. The purpose of this study was to clarify whether the expression of p53 is associated with that of HIF-1alpha...
  56. ncbi request reprint Angiogenic switch occurs during the precancerous stage of human esophageal squamous cell carcinoma
    Yasuhiko Kitadai
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biochemical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Oncol Rep 11:315-9. 2004
    ..Several different angiogenic factors produced by tumor cells and host cells may regulate angiogenesis during different steps of esophageal carcinogenesis...
  57. ncbi request reprint Involvement of Kruppel-like factor 6 (KLF6) mutation in the development of nonpolypoid colorectal carcinoma
    Shinichi Mukai
    Department of Endoscopy, Hiroshima University Hospital, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    World J Gastroenterol 13:3932-8. 2007
    ..To examine Kruppel-like factor 6 (KLF6) mutations in nonpolypoid-type tumors and alterations of K-ras, p53, and B-raf in relation between mutation and morphologic type, particularly nonpolypoid-type colorectal carcinomas...
  58. doi request reprint Identification of novel HCV deletion mutants in chronic hepatitis C patients
    Tomohiko Kohno
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Japan
    Antivir Ther 17:1551-61. 2012
    ..The HCV genome consists of a positive 9.6 kb single-strand of RNA. Nucleotide substitutions in the HCV genome are common and a 2 kb deletion has been reported...
  59. ncbi request reprint Advantage of endoscopic submucosal dissection compared with EMR for early gastric cancer
    Shiro Oka
    Department of Endoscopy, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Gastrointest Endosc 64:877-83. 2006
    ..In EMR of early gastric cancer (EGC), en bloc resection reduces the risk of residual cancer. Endoscopic submucosal dissection (ESD) now allows en bloc resection of large EGCs...
  60. ncbi request reprint Evaluation of colon cancer vascularity by flash echo imaging
    Madoka Nakao
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Scand J Gastroenterol 43:223-8. 2008
    ..The aim of this study was to confirm the usefulness of harmonic flash echo imaging (H-FEI) for the preoperative evaluation of tumor vascularity in colorectal cancer by comparison with CD34 staining of resected specimens...
  61. ncbi request reprint Predicting the need for surgery in Crohn's disease with contrast harmonic ultrasound
    Kayoko Kunihiro
    Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan
    Scand J Gastroenterol 42:577-85. 2007
    ....
  62. ncbi request reprint Optical biopsy of GI lesions by reflectance-type laser-scanning confocal microscopy
    Shigeto Yoshida
    Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan
    Gastrointest Endosc 66:144-9. 2007
    ..Laser-scanning confocal microscopy (LCM) is a new, noninvasive method of optical imaging that may be able to provide an instant microscopic image of untreated tissue under endoscopy...
  63. doi request reprint Quantitative analysis of colorectal lesions observed on magnified endoscopy images
    Keiichi Onji
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Gastroenterol 46:1382-90. 2011
    ..We investigated whether magnified endoscopy images of these pit patterns could be analyzed quantitatively and thus facilitate computer-aided diagnosis of colorectal lesions...
  64. ncbi request reprint Helicobacter pylori infection is the major risk factor for gastric inflammation in the cardia
    Yasuo Egi
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Dig Dis Sci 51:1582-8. 2006
    ..Cardiac inflammation was more pronounced in patients without GERD. These results suggest that H. pylori is a major risk factor for cardiac inflammation in the Japanese...
  65. doi request reprint Rapid emergence of telaprevir resistant hepatitis C virus strain from wildtype clone in vivo
    Nobuhiko Hiraga
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Hepatology 54:781-8. 2011
    ..Conclusion: Using deep sequencing technology and a genetically engineered HCV infection system, we showed that the rapid emergence of telaprevir-resistant HCV was induced by mutation from the wildtype strain of HCV in vivo...
  66. ncbi request reprint Prevalence of Helicobacter pylori resistance to clarithromycin and metronidazole determined by 23S ribosomal RNA and rdxA gene analyses in Hiroshima, Japan
    Toru Hiyama
    Health Service Center, Hiroshima University, Higashihiroshima, Japan
    J Gastroenterol Hepatol 18:1202-7. 2003
    ..pylori. The prevalence of H. pylori infections that are resistant to clarithromycin, metronidazole, or both were determined in H. pylori isolates in Hiroshima, Japan...
  67. ncbi request reprint A water-soluble extract from culture medium of Ganoderma lucidum mycelia suppresses the development of colorectal adenomas
    Shiro Oka
    Department of Endoscopy, Hiroshima University Hospital, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Hiroshima J Med Sci 59:1-6. 2010
    ..73 +/- 0.28 mm in the control group and decreased to -1.40 +/- 0.64 mm in the MAK group (p < 0.01). The resultssuggest that MAK suppresses the development of colorectal adenomas - precancerous lesions of the large bowel...
  68. doi request reprint Mesenchymal stem cells enhance growth and metastasis of colon cancer
    Kei Shinagawa
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Int J Cancer 127:2323-33. 2010
    ..Collectively, MSCs migrate and differentiate into CAFs in tumor stroma, and they promote growth and metastasis of colon cancer by enhancing angiogenesis, migration and invasion and by inhibiting apoptosis of tumor cells...
  69. doi request reprint Usefulness of endoscopic ultrasonography in determining the depth of invasion and indication for endoscopic treatment of early gastric cancer
    Ritsuo Mouri
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University Hospital, Hiroshima, Japan
    J Clin Gastroenterol 43:318-22. 2009
    ..However, a previously reported classification system tended to result in overstaging. We investigated the usefulness of EUS for evaluation of the depth of gastric cancer invasion and indications for endoscopic treatment...
  70. ncbi request reprint Lymphatic vessel density at the site of deepest penetration as a predictor of lymph node metastasis in submucosal colorectal cancer
    Iwao Kaneko
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Science, Hiroshima, Japan
    Dis Colon Rectum 50:13-21. 2007
    ..This study was designed to determine the usefulness of identification of lymphatic vessels by immunohistochemistry in predicting lymph node metastasis of submucosal colorectal cancer...