M Takumida

Summary

Affiliation: Hiroshima University
Country: Japan

Publications

  1. doi request reprint Localization of aquaporins in the mouse vestibular end organs
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University Hospital, Hiroshima, Japan
    Acta Otolaryngol 133:804-13. 2013
  2. doi request reprint Localization of aquaporins 1, 2, and 3 and vasopressin type 2 receptor in the mouse inner ear
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University Hospital, Japan
    Acta Otolaryngol 132:807-13. 2012
  3. ncbi request reprint Radical scavengers for Ménière's disease after failure of conventional therapy: a pilot study
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University School of Medicine, Hiroshima, Japan
    Acta Otolaryngol 123:697-703. 2003
  4. ncbi request reprint Functional significance of nitric oxide in the inner ear
    Masaya Takumida
    Department of Otolaryngology, Head and Neck Surgery, Hiroshima University Graduate School of Medicine, Hiroshima, Japan
    In Vivo 18:345-50. 2004
  5. doi request reprint Age-dependent changes in the expression of klotho protein, TRPV5 and TRPV6 in mouse inner ear
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University Faculty of Medicine, Hiroshima, Japan
    Acta Otolaryngol 129:1340-50. 2009
  6. ncbi request reprint Isosorbide delays gentamicin-induced vestibular sensory cell death
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University Faculty of Medicine, Hiroshima, Japan
    ORL J Otorhinolaryngol Relat Spec 67:276-81. 2005
  7. ncbi request reprint Ménière's disease: a long-term follow-up study of bilateral hearing levels
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University Faculty of Medicine, Hiroshima, Japan
    Acta Otolaryngol 126:921-5. 2006
  8. ncbi request reprint Protective effect of edaravone against endolymphatic hydrops
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University Faculty of Medicine, 1 2 3 Kasumicho, Minamiku, Hiroshima 734 8551, Japan
    Acta Otolaryngol 127:1124-31. 2007
  9. ncbi request reprint A new animal model for Ménière's disease
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University Faculty of Medicine, Hiroshima, Japan
    Acta Otolaryngol 128:263-71. 2008
  10. doi request reprint Radical scavengers for elderly patients with age-related hearing loss
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University School of Medicine, 1 2 3 Kasumicho, Minamiku, Hiroshima, Japan
    Acta Otolaryngol 129:36-44. 2009

Collaborators

Detail Information

Publications51

  1. doi request reprint Localization of aquaporins in the mouse vestibular end organs
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University Hospital, Hiroshima, Japan
    Acta Otolaryngol 133:804-13. 2013
    ....
  2. doi request reprint Localization of aquaporins 1, 2, and 3 and vasopressin type 2 receptor in the mouse inner ear
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University Hospital, Japan
    Acta Otolaryngol 132:807-13. 2012
    ....
  3. ncbi request reprint Radical scavengers for Ménière's disease after failure of conventional therapy: a pilot study
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University School of Medicine, Hiroshima, Japan
    Acta Otolaryngol 123:697-703. 2003
    ..To perform a trial to assess the efficacy of radical scavengers, i.e. rebamipide, vitamin C and glutathione, for the treatment of Ménière's disease (MD)...
  4. ncbi request reprint Functional significance of nitric oxide in the inner ear
    Masaya Takumida
    Department of Otolaryngology, Head and Neck Surgery, Hiroshima University Graduate School of Medicine, Hiroshima, Japan
    In Vivo 18:345-50. 2004
    ..Based on the mechanisms of inner ear disorders, new pharmacological strategies for preventing and/or treating inner ear disorders have also been suggested...
  5. doi request reprint Age-dependent changes in the expression of klotho protein, TRPV5 and TRPV6 in mouse inner ear
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University Faculty of Medicine, Hiroshima, Japan
    Acta Otolaryngol 129:1340-50. 2009
    ..Down-regulation of klotho also leads to down-regulation of TRPV5 and TRPV6, resulting in modified Ca(2+) homeostasis in the inner ear, dysfunction of sensory cell transduction and causing hearing loss and/or vestibular disorders...
  6. ncbi request reprint Isosorbide delays gentamicin-induced vestibular sensory cell death
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University Faculty of Medicine, Hiroshima, Japan
    ORL J Otorhinolaryngol Relat Spec 67:276-81. 2005
    ..Isosorbide inhibited the production of both NO and ROS. Isosorbide limited the vestibular sensory cell damage caused by gentamicin. It is, therefore, suggested that isosorbide may help to treat inner ear disorders...
  7. ncbi request reprint Ménière's disease: a long-term follow-up study of bilateral hearing levels
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University Faculty of Medicine, Hiroshima, Japan
    Acta Otolaryngol 126:921-5. 2006
    ....
  8. ncbi request reprint Protective effect of edaravone against endolymphatic hydrops
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University Faculty of Medicine, 1 2 3 Kasumicho, Minamiku, Hiroshima 734 8551, Japan
    Acta Otolaryngol 127:1124-31. 2007
    ..Our findings suggest that edaravone prevented the production of reactive oxygen species (ROS). Edaravone also delayed the formation of endolymphatic hydrops in guinea pigs, but had no effect on endolymphatic hydrops...
  9. ncbi request reprint A new animal model for Ménière's disease
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University Faculty of Medicine, Hiroshima, Japan
    Acta Otolaryngol 128:263-71. 2008
    ..Induction of vestibular dysfunction in the hydropic animal model may entail additional stress such as reduced inner ear blood flow, and sudden acute changes in endolymph volume and/or pressure...
  10. doi request reprint Radical scavengers for elderly patients with age-related hearing loss
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University School of Medicine, 1 2 3 Kasumicho, Minamiku, Hiroshima, Japan
    Acta Otolaryngol 129:36-44. 2009
    ..The results of this study suggest that treatment with radical scavengers has the potential to become an effective new therapy for age-related hearing loss...
  11. doi request reprint Effect of inner ear blood flow changes in Ménière's model mice
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University Faculty of Medicine, 1 2 3 Kasumicho, Minamiku, Hiroshima, Japan
    Acta Otolaryngol 129:244-53. 2009
    ..A dysfunctional ES can cause vertigo attacks following additional stress such as a sudden change in endolymphatic volume and/or pressure, or restricted inner ear blood flow...
  12. doi request reprint Expression of transient receptor potential channel melastin (TRPM) 1-8 and TRPA1 (ankyrin) in mouse inner ear
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University Faculty of Medicine, Hiroshima, Japan
    Acta Otolaryngol 129:1050-60. 2009
    ..It has been shown that TRPMs may play a functional role in sensory cell physiology, fluid homeostasis, sensory cell death, and thermosensation in the inner ear, while TRPA1 plays an important role in sensory transduction...
  13. doi request reprint Expression of canonical transient receptor potential channel (TRPC) 1-7 in the mouse inner ear
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University Faculty of Medicine, Hiroshima, Japan
    Acta Otolaryngol 129:1351-8. 2009
    ..It is suggested that TRPCs play a functional role in the sensory cell transduction system in the inner ear...
  14. doi request reprint Expression of transient receptor potential channel mucolipin (TRPML) and polycystine (TRPP) in the mouse inner ear
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University Faculty of Medicine, Hiroshima 734 8551, Japan
    Acta Otolaryngol 130:196-203. 2010
    ..TRPML3 may play distinct roles in the inner ear, such as stereociliar organization, sensory cell transduction, and inner ear fluid homeostasis, and TRPP3 may be important for fluid homeostasis in the inner ear...
  15. doi request reprint Localization of prostanoid receptors in the mouse inner ear
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University Hospital, Hiroshima, Japan
    Acta Otolaryngol 131:142-8. 2011
    ..EP4, EP2, and IP prostanoid receptors exert an otoprotective function and FP may be important for fluid homeostasis in the inner ear...
  16. ncbi request reprint Neuroprotection of vestibular sensory cells from gentamicin ototoxicity obtained using nitric oxide synthase inhibitors, reactive oxygen species scavengers, brain-derived neurotrophic factors and calpain inhibitors
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University Faculty of Medicine, Hiroshima, Japan
    Acta Otolaryngol 123:8-13. 2003
    ....
  17. ncbi request reprint Detection of nitric oxide in the guinea pig inner ear, using a combination of aldehyde fixative and 4,5-diaminofluorescein diacetate
    M Takumida
    Department of Otolaryngology, Hiroshima University School of Medicine, Japan
    Acta Otolaryngol 121:460-4. 2001
    ..Thus, detection of intracellular NO production by using a combination of glutaraldehyde fixation and DAF-2DA is useful for examining the function of NO in cells, both in situ and in vivo...
  18. ncbi request reprint Direct evidence of nitric oxide production in the guinea pig organ of Corti
    M Takumida
    Department of Otolaryngology, Hiroshima University School of Medicine, Japan
    Acta Otolaryngol 121:342-5. 2001
    ..This is the first direct evidence of NO production in the cochlea. NO may play an important role in the physiology of the organ of Corti and may also be involved in hearing disorders...
  19. ncbi request reprint Pharmacological models for inner ear therapy with emphasis on nitric oxide
    M Takumida
    Department of Otolaryngology, Hiroshima University School of Medicine, Japan
    Acta Otolaryngol 121:16-20. 2001
    ..Based on this hypothesis, reduction of glutamatergic excitotoxicity and inhibition of NOS, scavenging superoxide and scavenging peroxynitrite are thought to attenuate NO-mediated otoneurotoxicity...
  20. ncbi request reprint Nitric oxide in guinea pig vestibular sensory cells following gentamicin exposure in vitro
    M Takumida
    Department of Otolaryngology, Hiroshima University Faculty of Medicine, Japan
    Acta Otolaryngol 121:346-50. 2001
    ..These findings indicate that NO may play an important role in the ototoxicity of aminoglycoside...
  21. ncbi request reprint Lipopolysaccharide-induced expression of inducible nitric oxide synthase in the guinea pig organ of Corti
    M Takumida
    Department of Otolaryngology, Hiroshima University School of Medicine, 1 2 3 Kasumicho, Minamiku, Hiroshima, Japan
    Hear Res 140:91-8. 2000
    ..On the basis of these findings, it can be concluded that NO together with O(2)(-), which form the more reactive peroxynitrite, are the most important pathogenic agents in LPS-induced damage of cochlea in the guinea pig...
  22. ncbi request reprint Simultaneous detection of both nitric oxide and reactive oxygen species in guinea pig vestibular sensory cells
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University Faculty of Medicine, Hiroshima, Japan
    ORL J Otorhinolaryngol Relat Spec 64:143-7. 2002
    ..These findings could indicate that both NO and ROS play an important role in aminoglycoside ototoxicity...
  23. ncbi request reprint Functional morphology of the crista ampullaris: with special interests in sensory hairs and cupula: a review
    M Takumida
    Department of Otolaryngology, Hiroshima University School of Medicine, Hiroshima, Japan
    Biol Sci Space 15:356-8. 2001
    ..The subcupular meshwork may play a role in the transmission of the shear strain force of the cupula to the ciliary bundle and may also exert an additional damping effect in order to prevent unwanted vibrations...
  24. ncbi request reprint Brain-derived neurotrophic factor and nitric oxide synthase inhibitor protect the vestibular organ against gentamicin ototoxicity
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University Faculty of Medicine, Japan
    Acta Otolaryngol 122:10-5. 2002
    ..It is therefore suggested that treatment with a combination of an NOS inhibitor and a neurotrophin will help us to treat inner ear disorders...
  25. doi request reprint Changes in transient receptor potential vanilloid (TRPV) 1, 2, 3 and 4 expression in mouse inner ear following gentamicin challenge
    Takuya Ishibashi
    Department of Otolaryngology, Faculty of Medicine, Hiroshima University, Hiroshima, Japan
    Acta Otolaryngol 129:116-26. 2009
    ..It is suggested that transient receptor potential vanilloid (TRPV)-1 and -2 may be of pathological significance for sensory cells and ganglions, while TRPV-3 and -4 may play an important part in neuroprotection of the inner ear...
  26. ncbi request reprint Free radicals in the guinea pig inner ear following gentamicin exposure
    M Takumida
    Department of Otolaryngology, Hiroshima University School of Medicine, Hiroshima, Japan
    ORL J Otorhinolaryngol Relat Spec 61:63-70. 1999
    ..On the basis of these findings, it can be concluded that NO together with O-2, which form more reactive peroxynitrite, play an important role in GM ototoxicity in the guinea pig...
  27. ncbi request reprint Localization of soluble guanylate cyclase activity in the guinea pig inner ear
    M Takumida
    Deportment of Otolaryngology, Hiroshima University School of Medicine, Japan
    Acta Otolaryngol 120:28-33. 2000
    ..These findings suggest that the NO/cGMP pathway may be involved in regulatory processes in neurotransmission, blood flow and inner ear fluid homeostasis...
  28. doi request reprint Effect of inner ear blood flow changes on the endolymphatic sac
    Nana Akagi
    Hiroshima University School of Medicine, Hiroshima, Japan
    Acta Otolaryngol 128:1187-95. 2008
    ..That the endolymphatic sac (ES) reacts to changes in inner ear blood flow may be important for homeostasis of the inner ear fluid volume and pressure...
  29. ncbi request reprint Direct evidence of nitric oxide production in guinea pig vestibular sensory cells
    M Takumida
    Department of Otolaryngology, Hiroshima University School of Medicine, Japan
    Acta Otolaryngol 120:34-8. 2000
    ..This is the first direct evidence of NO production in the vestibular end organs. NO may play an important role for the vestibular physiology and also be involved in disease of the inner ear...
  30. ncbi request reprint Localization of nitric oxide synthase in human nasal mucosa with nasal allergy
    H Kawamoto
    Department of Otolaryngology, Hiroshima University School of Medicine, Japan
    Acta Otolaryngol Suppl 539:65-70. 1998
    ..These findings may suggest that the greater amounts of NO in the nasal air of patients with allergic rhinitis are mainly induced by iNOS activity...
  31. doi request reprint Protective effect of edaravone against tobramycin-induced ototoxicity
    Monika Stenkvist Asplund
    Department of Otolaryngology, Head and Neck Surgery, University Hospital, Uppsala, Sweden
    Acta Otolaryngol 129:8-13. 2009
    ..Even if the edaravone treatment is postponed for 7 days, it can still prevent hearing loss, but a 14 day delay cannot protect from ototoxicity...
  32. ncbi request reprint Calpain and caspase inhibitors protect vestibular sensory cells from gentamicin ototoxicity
    Akira Shimizu
    Department of Otolaryngology, Tokyo Medical University, Tokyo, Japan
    Acta Otolaryngol 123:459-65. 2003
    ..Caspases and calpains are regarded to be important factors in the regulation of cell death in the inner ear. We hypothesized that caspase or calpain inhibitors would protect hair cells from aminoglycoside ototoxicity...
  33. doi request reprint Effects of age and sex on the expression of estrogen receptor alpha and beta in the mouse inner ear
    Ray Motohashi
    Department of Otolaryngology, Tokyo Medical University, Tokyo 160 0023, Japan
    Acta Otolaryngol 130:204-14. 2010
    ..ERalpha may alter cochlear and vestibular sensory transduction, and ERbeta may have a neuroprotective function in the inner ear...
  34. ncbi request reprint Functional role of nitric oxide in the nasal mucosa of the guinea pig after instillation with lipopolysaccharide
    T Ueda
    Department of Otolaryngology, Hiroshima University School of Medicine, Japan
    Acta Otolaryngol 121:510-6. 2001
    ..LPS also induced a decrease in CBF, which was inhibited by dexamethasone or L-NAME. It is suggested that NO may play an important role in pathological changes in the nasal mucosa...
  35. pmc Expression of transient receptor potential channel vanilloid (TRPV) 1–4, melastin (TRPM) 5 and 8, and ankyrin (TRPA1) in the normal and methimazole-treated mouse olfactory epithelium
    Yousuke Nakashimo
    Department of Otolaryngology, Hiroshima University, Japan
    Acta Otolaryngol 130:1278-86. 2010
    ..In patients with olfactory disturbance, TRPV1 and TRPM8 may be closely related to a high rate of recognition of curry and menthol odors, while TRPV2 may also play a crucial role in the regeneration of olfactory receptor neurons...
  36. ncbi request reprint Localization of endotoxin in the inner ear following inoculation into the middle ear
    Masaya Takumida
    Hiroshima University School of Medicine, Hiroshima, Japan
    Acta Otolaryngol 124:772-7. 2004
    ..g. the round window, blood vessels or lymphatics, and/or interscala exchange, resulting in a disturbance not only of the cochlea but also of the vestibular end organs...
  37. ncbi request reprint Heat shock protein 70 delays gentamicin-induced vestibular hair cell death
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University Faculty of Medicine, Hiroshima, Japan
    Acta Otolaryngol 125:23-8. 2005
    ..These findings show that administration of GGA can protect vestibular sensory cells from GM ototoxicity and suggest that induction of HSP70 by GGA may be a useful adjunct for the treatment of vestibular disorders...
  38. ncbi request reprint Transient receptor potential channels in the inner ear: presence of transient receptor potential channel subfamily 1 and 4 in the guinea pig inner ear
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University Faculty of Medicine, Hiroshima, Japan
    Acta Otolaryngol 125:929-34. 2005
    ..The results of this study indicate that transient receptor potential subfamily 1 (TRPV1) may play a functional role in sensory cell physiology and that TRPV4 may be important for fluid homeostasis in the inner ear...
  39. ncbi request reprint Radical scavengers: a remedy for presbyacusis. A pilot study
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University School of Medicine, Hiroshima, Japan
    Acta Otolaryngol 125:1290-5. 2005
    ..The results of this study suggest that treatment with radical scavengers has the potential to become an effective new therapy for presbyacusis...
  40. ncbi request reprint Protective effect of edaravone against the ototoxicity of Pseudomonas aeruginosa exotoxin A
    Masaya Takumida
    Department of Otolaryngology, Faculty of Medicine, Hiroshima University, Minamiku, Hiroshima, Japan
    Acta Otolaryngol 126:15-9. 2006
    ..Our findings suggest that edaravone can protect against cochlear damage caused by Pseudomonas aeruginosa exotoxin A (PaExoA)...
  41. ncbi request reprint Effect of acute endolymphatic hydrops overload on the endolymphatic sac
    Nana Akagi
    Hiroshima University School of Medicine, Hiroshima, Japan
    Acta Otolaryngol 128:239-44. 2008
    ..Homeostasis of endolymph volume is a complex mechanism, in which the endolymphatic sac (ES) may play an important role...
  42. doi request reprint Expression of transient receptor potential vanilloid (TRPV) 1, 2, 3, and 4 in mouse inner ear
    Takuya Ishibashi
    Department of Otolaryngology, Hiroshima University Faculty of Medicine, Hiroshima, Japan
    Acta Otolaryngol 128:1286-93. 2008
    ..It is suggested that transient receptor potential vanilloids (TRPVs) may play a functional role in cell physiology and TRPV-4 and -2 may play an important part in fluid homeostasis in the inner ear...
  43. ncbi request reprint Carbohydrates of the vestibular end organs. An ultrastructural study using gold-labeled lectins
    M Takumida
    Department of Otolaryngology, Hiroshima University School of Medicine, Japan
    ORL J Otorhinolaryngol Relat Spec 53:86-90. 1991
    ....
  44. ncbi request reprint Nitric oxide in the inner ear
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University School of Medicine, Hiroshima, Japan
    Curr Opin Neurol 15:11-5. 2002
    ..Based on the mechanisms of inner ear disorders, new pharmacological strategies for preventing or treating inner ear disorders have been suggested...
  45. ncbi request reprint Protective effect of brain-derived neurotrophic factor against the ototoxicity of Pseudomonas aeruginosa exotoxin A
    Manabu Maeta
    Department of Otorhinolaryngology and Head and Neck Surgery, Uppsala University Hospital, Uppsala, Sweden
    Acta Otolaryngol 123:14-9. 2003
    ..The combined effect of BDNF and N(G)-nitro-L-arginine methyl ester (L-NAME) was also investigated...
  46. ncbi request reprint Nitro-L-arginine methyl ester: a potential protector against gentamicin ototoxicity
    Leif Nordang
    Department of Otolaryngology and Head and Neck Surgery, University Hospital Akademiska sjukhuset, Uppsala, Sweden
    Acta Otolaryngol 125:1033-8. 2005
    ..L-NAME reduced gentamicin-induced hearing loss in the high-frequency range, but gave no protection in the middle or low frequencies...
  47. ncbi request reprint Additive effects of toxin exposure and destruction of semicircular canal on cochlear function: an auditory brainstem response study in the rat
    Monika Stenqvist
    Department of Otolaryngology and Head and Neck Surgery, University Hospital Akademiska sjukhuset, Uppsala, Sweden
    Acta Otolaryngol 124:13-8. 2004
    ..To ascertain whether the severity of toxin-related hearing loss and the interval between instillation of toxin and surgical trauma affect hearing recovery capacity following semicircular canal (SCC) surgery in the rat...
  48. ncbi request reprint Otological Wegener's granulomatosis at the time of initial presentation: a potential diagnostic dilemma
    Alfio Ferlito
    Acta Otolaryngol 123:675-7. 2003
  49. doi request reprint Reliable lip force measurement in healthy controls and in patients with stroke: a methodologic study
    Mary Hägg
    Department of Otorhinolaryngology, Hudiksvall Hospital, Hudiksvall, Sweden
    Dysphagia 23:291-6. 2008
    ..3 N and 9.5 +/- 5.5 N, p < 0.001). The sensitivity of LF100 was 91% and the specificity 95%. The cutoff level for normal lip force was 15 N. The LF100 showed itself to be a suitable and reliable instrument for measuring lip force...
  50. ncbi request reprint Radioimmunotherapy with astatine-211 using chimeric monoclonal antibody U36 in head and neck squamous cell carcinoma
    Junping Cheng
    Department of Oto Rhino Laryngology and Head and Neck Surgery, Uppsala University Hospital Akademiska sjukhuset, Uppsala, Sweden
    Laryngoscope 117:1013-8. 2007
    ..We aim to evaluate the biodistribution and therapeutic effect of radioimmunotherapy using the alpha emitting, astatine-211-labeled, chimeric monoclonal antibody U36 (U36) on the HNSCC cell line UT-SCC7 in vivo...
  51. ncbi request reprint Morphologic changes in round window membrane after topical hydrocortisone and dexamethasone treatment
    Leif Nordang
    Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital, Uppsala, Sweden
    Otol Neurotol 24:339-43. 2003
    ..Are all glucocorticoids supposed to have the same effect on the round window membrane?..