T Shimatani

Summary

Affiliation: Hiroshima University
Country: Japan

Publications

  1. ncbi Acid-suppressive effects of generic omeprazole: comparison of three brands of generic omeprazole with original omeprazole
    T Shimatani
    Department of General Medicine, Hiroshima University Hospital, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Dig Liver Dis 38:554-9. 2006
  2. ncbi Acid-suppressive effects of rabeprazole, omeprazole, and lansoprazole at reduced and standard doses: a crossover comparative study in homozygous extensive metabolizers of cytochrome P450 2C19
    Tomohiko Shimatani
    Department of General Medicine, Hiroshima University Hospital, Department of Geriatric Health Sciences, Graduate School of Health Sciences, Hiroshima University, Hiroshima, Japan
    Clin Pharmacol Ther 79:144-52. 2006
  3. ncbi Which has superior acid-suppressive effect, 10 mg omeprazole once daily or 20 mg famotidine twice daily? Effects of single or repeated administration in Japanese Helicobacter pylori-negative CYP2C19 extensive metabolizers
    Tomohiko Shimatani
    Department of General Medicine, Hiroshima University Hospital, 1 2 3 Kasumi, Hiroshima, Japan
    Dig Dis Sci 52:390-5. 2007
  4. ncbi Acid-suppressive effects of rabeprazole: comparing 10mg and 20mg twice daily in Japanese Helicobacter pylori-negative and -positive CYP2C19 extensive metabolisers
    T Shimatani
    Department of General Medicine, Hiroshima University Hospital, 1 2 3 Kasumi, Hiroshima 734 8551, Japan
    Dig Liver Dis 38:802-8. 2006
  5. ncbi Lafutidine, a newly developed antiulcer drug, elevates postprandial intragastric pH and increases plasma calcitonin gene-related peptide and somatostatin concentrations in humans: comparisons with famotidine
    Tomohiko Shimatani
    Department of General Medicine, Hiroshima University Hospital, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Dig Dis Sci 51:114-20. 2006
  6. ncbi Prevalence of Helicobacter pylori infection, endoscopic gastric findings and dyspeptic symptoms among a young Japanese population born in the 1970s
    Tomohiko Shimatani
    Department of General Medicine, Hiroshima University Hospital, Japan
    J Gastroenterol Hepatol 20:1352-7. 2005
  7. ncbi Acid-suppressive efficacy of a reduced dosage of rabeprazole: comparison of 10 mg twice daily rabeprazole with 20 mg twice daily rabeprazole, 30 mg twice daily lansoprazole, and 20 mg twice daily omeprazole by 24-hr intragastric pH-metry
    Tomohiko Shimatani
    Department of General Medicine, Hiroshima University Hospital, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Dig Dis Sci 50:1202-6. 2005
  8. ncbi Gastric acidity in patients with follicular gastritis is significantly reduced, but can be normalized after eradication for Helicobacter pylori
    Tomohiko Shimatani
    Department of General Medicine, Hiroshima University Hospital, Hiroshima, Japan
    Helicobacter 10:256-65. 2005
  9. ncbi Gastric acid normosecretion is not essential in the pathogenesis of mild erosive gastroesophageal reflux disease in relation to Helicobacter pylori status
    Tomohiko Shimatani
    Department of General Medicine, Hiroshima University Hospital, Hiroshima, Japan
    Dig Dis Sci 49:787-94. 2004
  10. ncbi Rabeprazole 10 mg twice daily is superior to 20 mg once daily for night-time gastric acid suppression
    T Shimatani
    Department of General Medicine, Hiroshima University Hospital, Hiroshima, Japan
    Aliment Pharmacol Ther 19:113-22. 2004

Detail Information

Publications19

  1. ncbi Acid-suppressive effects of generic omeprazole: comparison of three brands of generic omeprazole with original omeprazole
    T Shimatani
    Department of General Medicine, Hiroshima University Hospital, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Dig Liver Dis 38:554-9. 2006
    ..Generic omeprazole contains the same active ingredient as original omeprazole and require verification of the bioequivalence with original omeprazole. However, very few clinical studies have been reported...
  2. ncbi Acid-suppressive effects of rabeprazole, omeprazole, and lansoprazole at reduced and standard doses: a crossover comparative study in homozygous extensive metabolizers of cytochrome P450 2C19
    Tomohiko Shimatani
    Department of General Medicine, Hiroshima University Hospital, Department of Geriatric Health Sciences, Graduate School of Health Sciences, Hiroshima University, Hiroshima, Japan
    Clin Pharmacol Ther 79:144-52. 2006
    ..0 at night, should be inhibited. A "step-down" therapy sometimes fails because of insufficient acid suppression. Therefore we compared the acid-suppressive effects of proton pump inhibitors...
  3. ncbi Which has superior acid-suppressive effect, 10 mg omeprazole once daily or 20 mg famotidine twice daily? Effects of single or repeated administration in Japanese Helicobacter pylori-negative CYP2C19 extensive metabolizers
    Tomohiko Shimatani
    Department of General Medicine, Hiroshima University Hospital, 1 2 3 Kasumi, Hiroshima, Japan
    Dig Dis Sci 52:390-5. 2007
    ..This discrepancy possibly results from the "potentiation" of acid-suppressive effect of omeprazole and the "tolerance" phenomenon in respect to famotidine...
  4. ncbi Acid-suppressive effects of rabeprazole: comparing 10mg and 20mg twice daily in Japanese Helicobacter pylori-negative and -positive CYP2C19 extensive metabolisers
    T Shimatani
    Department of General Medicine, Hiroshima University Hospital, 1 2 3 Kasumi, Hiroshima 734 8551, Japan
    Dig Liver Dis 38:802-8. 2006
    ..pylori) and is also proposed as therapy for refractory gastro-oesophageal reflux disease. However, there has not been a comprehensive assessment of its acid-suppressive effects...
  5. ncbi Lafutidine, a newly developed antiulcer drug, elevates postprandial intragastric pH and increases plasma calcitonin gene-related peptide and somatostatin concentrations in humans: comparisons with famotidine
    Tomohiko Shimatani
    Department of General Medicine, Hiroshima University Hospital, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Dig Dis Sci 51:114-20. 2006
    ..We concluded that lafutidine increases plasma concentrations of CGRP and somatostatin in humans, which may result in inhibition of postprandial acid secretion and gastroprotective activity...
  6. ncbi Prevalence of Helicobacter pylori infection, endoscopic gastric findings and dyspeptic symptoms among a young Japanese population born in the 1970s
    Tomohiko Shimatani
    Department of General Medicine, Hiroshima University Hospital, Japan
    J Gastroenterol Hepatol 20:1352-7. 2005
    ..With the prevalence of Helicobacter pylori (H. pylori) infection rapidly decreasing in Japan, endoscopic findings and dyspeptic symptoms need to be re-evaluated...
  7. ncbi Acid-suppressive efficacy of a reduced dosage of rabeprazole: comparison of 10 mg twice daily rabeprazole with 20 mg twice daily rabeprazole, 30 mg twice daily lansoprazole, and 20 mg twice daily omeprazole by 24-hr intragastric pH-metry
    Tomohiko Shimatani
    Department of General Medicine, Hiroshima University Hospital, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Dig Dis Sci 50:1202-6. 2005
    ..In conclusion, for acid-suppressive efficacy, a reduced dosage of rabeprazole is comparable to high dosages of rabeprazole, lansoprazole, and omeprazole...
  8. ncbi Gastric acidity in patients with follicular gastritis is significantly reduced, but can be normalized after eradication for Helicobacter pylori
    Tomohiko Shimatani
    Department of General Medicine, Hiroshima University Hospital, Hiroshima, Japan
    Helicobacter 10:256-65. 2005
    ..Follicular gastritis is thought to be caused by Helicobacter pylori infection. However, the pathophysiology of it remains unclear...
  9. ncbi Gastric acid normosecretion is not essential in the pathogenesis of mild erosive gastroesophageal reflux disease in relation to Helicobacter pylori status
    Tomohiko Shimatani
    Department of General Medicine, Hiroshima University Hospital, Hiroshima, Japan
    Dig Dis Sci 49:787-94. 2004
    ..In conclusion, in some GERD patients, gastric acid secretion was significantly decreased. Increased or maintained gastric acid secretion was not essential in the pathogenesis of mild GERD...
  10. ncbi Rabeprazole 10 mg twice daily is superior to 20 mg once daily for night-time gastric acid suppression
    T Shimatani
    Department of General Medicine, Hiroshima University Hospital, Hiroshima, Japan
    Aliment Pharmacol Ther 19:113-22. 2004
    ..Insufficient acid suppression is one of the main causes of proton pump inhibitor-refractory gastro-oesophageal reflux disease...
  11. ncbi Effect of omeprazole 10 mg on intragastric pH in three different CYP2C19 genotypes, compared with omeprazole 20 mg and lafutidine 20 mg, a new H2-receptor antagonist
    T Shimatani
    Department of General Medicine, Hiroshima University Hospital, Hiroshima, Japan
    Aliment Pharmacol Ther 18:1149-57. 2003
    ..Omeprazole 10 mg is used as maintenance therapy for gastro-oesophageal reflux disease, but previous reports have not mentioned the potency of its acid suppression...
  12. ncbi Acid-suppressive effects of various regimens of omeprazole in Helicobacter pylori-negative CYP2C19 homozygous extensive metabolizers: which regimen has the strongest effect?
    Tomohiko Shimatani
    Department of General Medicine, Hiroshima University Hospital, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8551, Japan
    Dig Dis Sci 52:2826-32. 2007
    ..05). In 4 of the 5 regimens, all 7 subjects had nocturnal acid breakthrough, whereas with 20 mg bid it occurred in only 3. We concluded that, considering nighttime acid suppression, omeprazole 20 mg bid had the strongest effect...
  13. ncbi Calcitonin gene-related peptide and somatostatin releases correlated with the area under the lafutidine concentration-time curve in human plasma
    K Ikawa
    Department of Clinical Pharmacotherapy, Hiroshima University, Hiroshima, Japan
    J Clin Pharm Ther 31:351-6. 2006
    ....
  14. ncbi [Helicobacter pylori infection and endoscopic gastric findings among a young Japanese population]
    Tomohiko Shimatani
    Department of General Medicine, Hiroshima University Hospital
    Nippon Rinsho 63:167-71. 2005
  15. ncbi Pharmacokinetic and pharmacodynamic properties of lafutidine after postprandial oral administration in healthy subjects: comparison with famotidine
    Kazuro Ikawa
    Department of Clinical Pharmacotherapy, Hiroshima University
    Biol Pharm Bull 30:1003-6. 2007
    ..These results indicated that the pharmacokinetic and pharmacodynamic properties of lafutidine after postprandial oral administration were different from those of famotidine at least 4.5 h after dosing...
  16. ncbi [Physiopathology of Helicobacter pyroli infection: Gastric acid secretion]
    Tomohiko Shimatani
    Department of General Medicine, Hiroshima University Hospital
    Nippon Rinsho 60:229-34. 2002
  17. ncbi Evaluation of gastric acid secretion in two patients (each aged over 90 years) with Helicobacter pylori-negative nonsteroidal anti-inflammatory drug-caused duodenal ulcers
    Tomohiko Shimatani
    Department of General Medicine, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
    J Gastroenterol 38:164-9. 2003
    ..In conclusion, gastric acid secretion in patients with H. pylori-negative NSAID-caused duodenal ulcers is fully maintained even in the elderly, so PPIs may be the first choice of treatment...
  18. ncbi The pharmacodynamic effect of omeprazole 10 mg and 20 mg once daily in patients with nonerosive reflux disease in Japan
    Yoshikazu Kinoshita
    Department of Gastroenterology and Hepatology, Shimane University School of Medicine, Izumo, 693-8501, Japan
    J Gastroenterol 41:554-61. 2006
    ..CONCLUSIONS: Omeprazole 10 mg or 20 mg reduces the percentage of time with intraesophageal pH < 4, is efficacious, and is well tolerated in patients with NERD in Japan, regardless of the patient's endoscopic classification...
  19. ncbi Validity of endoscopic classification of nonerosive reflux disease
    Takashi Joh
    Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Gastroenterol 42:444-9. 2007
    ..This study examined the usefulness of such changes in characterizing the pathophysiology of NERD...