H Nakayama

Summary

Affiliation: Hiroshima University
Country: Japan

Publications

  1. ncbi Lack of vascular adventitial fibroblastic cells in tumour stroma of intestinal-type and solid-type gastric carcinomas
    H Nakayama
    Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Clin Pathol 57:183-5. 2004
  2. ncbi Alpha smooth muscle actin positive stromal cells in gastric carcinoma
    H Nakayama
    Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Clin Pathol 55:741-4. 2002
  3. ncbi Presence of perivenular elastic fibers in nonalcoholic steatohepatitis Fibrosis Stage III
    H Nakayama
    Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi, Minami Ku, Hiroshima, Japan
    Histol Histopathol 23:407-9. 2008
  4. ncbi High molecular weight caldesmon positive stromal cells in the capsule of thyroid follicular tumours and tumour-like lesions
    H Nakayama
    First Department of Pathology, Kochi Medical School, Nankoku City, Kochi 783 8505, Japan
    J Clin Pathol 55:917-20. 2002
  5. ncbi Presence of vascular adventitial fibroblastic cells in diffuse-type gastric carcinomas
    H Nakayama
    Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Clin Pathol 57:970-2. 2004
  6. ncbi High molecular weight caldesmon positive stromal cells in the capsule of hepatocellular carcinomas
    H Nakayama
    Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi Minami ku, Hiroshima 734 8551, Japan
    J Clin Pathol 57:776-7. 2004
  7. ncbi CD34-positive stromal cells in primary lung carcinomas
    Hirofumi Nakayama
    Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734 8551, Japan
    Oncol Rep 10:1313-6. 2003
  8. ncbi Distribution and role of CD34-positive stromal cells and myofibroblasts in human normal testicular stroma
    N Kuroda
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi, Japan
    Histol Histopathol 19:743-51. 2004
  9. ncbi Down-regulation of the claudin-18 gene, identified through serial analysis of gene expression data analysis, in gastric cancer with an intestinal phenotype
    Y Sanada
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, 734-8551, Japan
    J Pathol 208:633-42. 2006
  10. ncbi Cytokeratin-positive subserosal myofibroblasts in gastroduodenal ulcer; another type of myofibroblasts
    L Guo
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi, Japan
    Histol Histopathol 21:697-704. 2006

Collaborators

Detail Information

Publications71

  1. ncbi Lack of vascular adventitial fibroblastic cells in tumour stroma of intestinal-type and solid-type gastric carcinomas
    H Nakayama
    Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Clin Pathol 57:183-5. 2004
    ..To investigate the roles of vascular adventitial fibroblastic cells in tumour stroma, the distribution of vascular adventitial fibroblastic cells was studied in gastric carcinomas...
  2. ncbi Alpha smooth muscle actin positive stromal cells in gastric carcinoma
    H Nakayama
    Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Clin Pathol 55:741-4. 2002
    ....
  3. ncbi Presence of perivenular elastic fibers in nonalcoholic steatohepatitis Fibrosis Stage III
    H Nakayama
    Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi, Minami Ku, Hiroshima, Japan
    Histol Histopathol 23:407-9. 2008
    ..In liver needle biopsy specimens of NASH, detection of perivenular elastic fibers is useful in deciding Fibrosis Stage III...
  4. ncbi High molecular weight caldesmon positive stromal cells in the capsule of thyroid follicular tumours and tumour-like lesions
    H Nakayama
    First Department of Pathology, Kochi Medical School, Nankoku City, Kochi 783 8505, Japan
    J Clin Pathol 55:917-20. 2002
    ..To investigate the smooth muscle nature of the spindle stromal cells in the capsule of thyroid tumours and tumour-like lesions...
  5. ncbi Presence of vascular adventitial fibroblastic cells in diffuse-type gastric carcinomas
    H Nakayama
    Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Clin Pathol 57:970-2. 2004
    ....
  6. ncbi High molecular weight caldesmon positive stromal cells in the capsule of hepatocellular carcinomas
    H Nakayama
    Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi Minami ku, Hiroshima 734 8551, Japan
    J Clin Pathol 57:776-7. 2004
    ..To investigate the smooth muscle nature of the stromal cells in the capsule of hepatocellular carcinomas...
  7. ncbi CD34-positive stromal cells in primary lung carcinomas
    Hirofumi Nakayama
    Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734 8551, Japan
    Oncol Rep 10:1313-6. 2003
    ..These results suggest that CD34-positive stromal cells are specific in the stroma of primary lung adenocarcinomas, and there is a possibility that CD34-positive stromal cells may play a supportive role in primary lung adenocarcinomas...
  8. ncbi Distribution and role of CD34-positive stromal cells and myofibroblasts in human normal testicular stroma
    N Kuroda
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi, Japan
    Histol Histopathol 19:743-51. 2004
    ..This distribution and cytological identification was also confirmed by an ultrastructural study of four cases. Finally, CD34-positive stromal cells and myofibroblasts are major components of human testicular stroma...
  9. ncbi Down-regulation of the claudin-18 gene, identified through serial analysis of gene expression data analysis, in gastric cancer with an intestinal phenotype
    Y Sanada
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, 734-8551, Japan
    J Pathol 208:633-42. 2006
    ..9%) (p = 0.0224). These results indicate that claudin-18 is a good marker of poor survival in GC. Down-regulation of claudin-18 may be involved in GCs with an intestinal phenotype, and may be an early event in gastric carcinogenesis...
  10. ncbi Cytokeratin-positive subserosal myofibroblasts in gastroduodenal ulcer; another type of myofibroblasts
    L Guo
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi, Japan
    Histol Histopathol 21:697-704. 2006
    ..In contrast, in the surface layer of ulceration, stromal cells expressing only ASMA were observed. The cytokeratin-positive subserosal myofibroblastic cell in human gastroduodenal ulcer is a novel type of myofibroblast...
  11. ncbi CD34 expression as a novel marker of transformed mesangial cells in biopsied glomerular diseases
    K Naruse
    First Department of Pathology, Kochi Medical School, Kochi 783 8505
    J Pathol 189:105-11. 1999
    ..These studies indicate that CD34 is a useful marker of mesangial transformation and that immunohistochemical examination with the anti-CD34 antibody is useful for the diagnosis and stage determination of glomerular diseases...
  12. ncbi Differential expression of CD34 in normal colorectal tissue, peritumoral inflammatory tissue, and tumour stroma
    H Nakayama
    Department of Pathology, Kure National Hospital, Hiroshima, Japan
    J Clin Pathol 53:626-9. 2000
    ....
  13. ncbi The role of myofibroblasts at the tumor border of invasive colorectal adenocarcinomas
    H Nakayama
    First Department of Pathology, Kochi Medical School, Japan
    Jpn J Clin Oncol 28:615-20. 1998
    ..In order to elucidate the significance of myofibroblasts in invasive growth of colorectal adenocarcinomas, we examined the number of myofibroblasts at the tumor border of colorectal adenocarcinomas...
  14. ncbi Differential expression of high molecular weight caldesmon in colorectal pericryptal fibroblasts and tumour stroma
    H Nakayama
    First Department of Pathology, Kochi Medical School, Japan
    J Clin Pathol 52:785-6. 1999
    ..To investigate an extent of smooth muscle differentiation of pericryptal fibroblasts...
  15. ncbi The specific distribution of dendritic interstitial cells at the tumor border of major salivary gland pleomorphic adenomas
    H Nakayama
    First Department of Pathology, Kochi Medical School, Japan
    Mod Pathol 12:445-9. 1999
    ....
  16. ncbi The distribution and role of myofibroblasts and CD34-positive stromal cells in normal pancreas and various pancreatic lesions
    N Kuroda
    Department of Pathology, Kochi Medical School, Kochi, Japan
    Histol Histopathol 19:59-67. 2004
    ..Myofibroblasts and CD34-positive stromal cells may play a role in regulating the tumor growth in the capsule of islet cell tumors of the pancreas...
  17. ncbi Well differentiated adult-type fibrosarcoma arising from the occipital subcutaneous tissue in a 17-year-old man: case report with immunohistochemical study
    H Nakayama
    First Department of Pathology, Kochi Medical School, Japan
    Jpn J Clin Oncol 28:511-6. 1998
    ....
  18. ncbi The distribution of CD34-positive stromal cells and myofibroblasts in colorectal carcinoid tumors
    N Kuroda
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi University, Kochi 783 8505, Japan
    Histol Histopathol 20:27-33. 2005
    ..Namely, CD34-positive stromal cells existed between neoplastic nests in large-sized carcinoid tumors. Myofibroblasts in the stroma of colorectal neoplasms may originate from CD34-positive stromal cells...
  19. ncbi So-called neoplastic myoepithelial cells in chondroid syringomas/mixed tumors of the skin: their subtypes and immunohistochemical analysis
    H Nakayama
    First Department of Pathology, Kochi Medical School, Japan
    Pathol Int 48:245-53. 1998
    ..The findings also suggest that the polyhedral cells show differentiation toward basal cells of the sweat gland dermal ducts or myoepithelial cells...
  20. ncbi Adenoid basal carcinoma of the uterine cervix: a case report with ultrastructural findings
    M Hiroi
    First Department of Pathology, Kochi Medical School, Kohasu, Okoh cho, Nankoku City, Kochi 783 8505, Japan
    Med Electron Microsc 33:241-5. 2000
    ..Furthermore, both tumors are considered to originate in the reserve cells of the uterine cervix. Because their outcomes are different, they should be distinguished from each other...
  21. ncbi Neuroepithelial and ependymal changes in HTX rats with congenital hydrocephalus: an ultrastructural and immunohistochemical study
    Y Nojima
    Department of Neurosurgery, Kochi Medical School, Japan
    Pathol Int 48:115-25. 1998
    ..These morphological changes suggested that preferential involvement of the lateral ventricular neuroepithelium might be closely associated with the pathogenesis of congenital hydrocephalus in HTX rats...
  22. ncbi Differential expression of claudin-2 in normal human tissues and gastrointestinal carcinomas
    Phyu Phyu Aung
    Department of Molecular Pathology, Graduate School of Biomedical Sciences Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, Japan
    Virchows Arch 448:428-34. 2006
    ..These results suggest that the expression of claudin-2 may involve organ specificity, and increased expression of claudin-2 may participate in colorectal carcinogenesis...
  23. ncbi Adenocarcinoma arising from a gastric duplication cyst with invasion to the stomach: a case report with literature review
    K Kuraoka
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan
    J Clin Pathol 57:428-31. 2004
    ..Duplication cysts should be included in the differential diagnosis of cystic masses of the gastrointestinal tract, and the possibility of malignancy within these cysts should be considered...
  24. ncbi Lack of CD34 positive stromal cells within angiomyomas (vascular leiomyomas)
    H Nakayama
    First Department of Pathology, Kochi Medical School, Kochi, 783 8505 Japan
    J Clin Pathol 55:395-6. 2002
    ..To investigate the role of CD34 positive stromal cells in the morphogenesis and tumour growth regulation of angiomyomas (vascular leiomyomas)...
  25. ncbi Systematic search for gastric cancer-specific genes based on SAGE data: melanoma inhibitory activity and matrix metalloproteinase-10 are novel prognostic factors in patients with gastric cancer
    P P Aung
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Oncogene 25:2546-57. 2006
    ..As expression of MIA and MMP-10 is narrowly restricted in cancer, these two molecules may be good therapeutic targets for GC...
  26. ncbi Expression of integrin-linked kinase is closely correlated with invasion and metastasis of gastric carcinoma
    Reiko Ito
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
    Virchows Arch 442:118-23. 2003
    ..ILK might be a novel molecular marker for aggressive gastric cancer...
  27. ncbi Expression and localization of Reg IV in human neoplastic and non-neoplastic tissues: Reg IV expression is associated with intestinal and neuroendocrine differentiation in gastric adenocarcinoma
    Naohide Oue
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan
    J Pathol 207:185-98. 2005
    ....
  28. ncbi Compound melanocytic nevus arising in a mature cystic teratoma of the ovary
    N Kuroda
    First Department of Pathology, Kochi Medical School, Nankoku City, Japan
    Pathol Int 51:902-4. 2001
    ..Despite the extreme rarity of such a lesion, pathologists should recognize the possibility of such lesions occurring in ovarian teratoma...
  29. ncbi Expression of Cbl linking with the epidermal growth factor receptor system is associated with tumor progression and poor prognosis of human gastric carcinoma
    Reiko Ito
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8551 Hiroshima, Japan
    Virchows Arch 444:324-31. 2004
    ..These results suggest that Cbl in connection with the EGFR system may be associated with stomach carcinogenesis, invasion and metastasis. Cbl may serve as a novel molecular marker for aggressive gastric carcinoma...
  30. ncbi Frequent loss of RUNX3 expression by promoter hypermethylation in gastric carcinoma
    Yasuhiro Oshimo
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Pathobiology 71:137-43. 2004
    ..Our results overall suggest that transcriptional inactivation of RUNX3 by promoter hypermethylation may participate in the stomach carcinogenesis...
  31. ncbi Gene expression profile of gastric carcinoma: identification of genes and tags potentially involved in invasion, metastasis, and carcinogenesis by serial analysis of gene expression
    Naohide Oue
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Cancer Res 64:2397-405. 2004
    ..Our results provide a list of candidate genes that are potentially involved in invasion, metastasis, and carcinogenesis of GC. REGIV may serve as a specific biomarker for GC...
  32. ncbi Search for new biomarkers of gastric cancer through serial analysis of gene expression and its clinical implications
    Wataru Yasui
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Minami Ku, Hiroshima 734 8551, Japan
    Cancer Sci 95:385-92. 2004
    ....
  33. ncbi Expression of POT1 is associated with tumor stage and telomere length in gastric carcinoma
    Tomohiro Kondo
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Cancer Res 64:523-9. 2004
    ..Moreover, changes in POT1 expression levels may be associated with stomach carcinogenesis and GC progression...
  34. ncbi Loss of maspin expression is associated with development and progression of gastric carcinoma with p53 abnormality
    Reiko Ito
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Oncol Rep 12:985-90. 2004
    ..Loss of maspin expression may serve as a biological marker of high-grade malignancy...
  35. ncbi Loss of heterozygosity and histone hypoacetylation of the PINX1 gene are associated with reduced expression in gastric carcinoma
    Tomohiro Kondo
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Oncogene 24:157-64. 2005
    ..These results indicate that LOH of PINX1 locus and hypoacetylation of histone H4 in the 5' UTR of PINX1 are associated with reduced expression of PINX1 in GC...
  36. ncbi Genes involved in invasion and metastasis of gastric cancer identified by array-based hybridization and serial analysis of gene expression
    Naohide Oue
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Oncology 69:17-22. 2005
    ..We also discuss the significance of HMGB1/amphoterin in invasion and metastasis of GC...
  37. ncbi A single nucleotide polymorphism in the extracellular domain of TRAIL receptor DR4 at nucleotide 626 in gastric cancer patients in Japan
    Kazuya Kuraoka
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Oncol Rep 14:465-70. 2005
    ..In conclusion, a Thr to Arg single nucleotide polymorphism in the extracellular domain of DR4 could not be associated with the development and progression of gastric cancer...
  38. ncbi DNA hypermethylation and histone hypoacetylation of the HLTF gene are associated with reduced expression in gastric carcinoma
    Yoichi Hamai
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Minami Ku, Hiroshima 734 8551, Japan
    Cancer Sci 94:692-8. 2003
    ..These results suggest that transcriptional inactivation of HLTF by aberrant DNA methylation and histone deacetylation may be involved in stomach carcinogenesis through down-regulation of HLTF expression...
  39. ncbi Histone acetylation and gastrointestinal carcinogenesis
    Wataru Yasui
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Ann N Y Acad Sci 983:220-31. 2003
    ..Therefore, histone acetylation should be a promising target for cancer therapy, especially against invasive and metastatic disease, but also for cancer prevention...
  40. ncbi Expression of RHOC is associated with metastasis of gastric carcinomas
    Tomohiro Kondo
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Pathobiology 71:19-25. 2004
    ..It has recently been reported that RHOC contributes to the metastatic phenotype of melanoma cells. The purpose of this study was to clarify its biological relevance to gastric carcinogenesis and metastasis...
  41. ncbi Promoter methylation of cyclin D2 gene in gastric carcinoma
    Yasuhiro Oshimo
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8551, Japan
    Int J Oncol 23:1663-70. 2003
    ..These results suggest that DNA hypomethylation is a mechanism underlying the increased expression of cyclin D2 in cancer cells and that demethylation of cyclin D2 may be involved in development and progression of gastric carcinoma...
  42. ncbi DNA methylation of genes linked with retinoid signaling in gastric carcinoma: expression of the retinoid acid receptor beta, cellular retinol-binding protein 1, and tazarotene-induced gene 1 genes is associated with DNA methylation
    Mariko Shutoh
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Kasumi, Hiroshima, Japan
    Cancer 104:1609-19. 2005
    ..In this study, the authors investigated the methylation status of these genes and analyzed the role of their DNA methylation in GC...
  43. ncbi Expression of thrombospondin-1 is correlated with microvessel density in gastric carcinoma
    Jie Zhang
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 734-8551, Hiroshima, Japan
    Virchows Arch 442:563-8. 2003
    ..Our results support an idea that increased TSP-1 expression may be associated with an angiogenic phenotype in gastric carcinoma and suggest that TSP-1 may play diverse roles in each organ...
  44. ncbi Accumulation of DNA methylation is associated with tumor stage in gastric cancer
    Naohide Oue
    Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan
    Cancer 106:1250-9. 2006
    ..DNA methylation of tumor-related genes accumulates in conjunction with tumor progression...
  45. ncbi Histone H3 acetylation is associated with reduced p21(WAF1/CIP1) expression by gastric carcinoma
    Yoshitsugu Mitani
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    J Pathol 205:65-73. 2005
    ..These findings provide evidence that alteration of histone acetylation occurs in human cancer tissue specimens such as those from gastric carcinoma...
  46. ncbi Molecular-pathological prognostic factors of gastric cancer: a review
    Wataru Yasui
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
    Gastric Cancer 8:86-94. 2005
    ..A combination of these examinations can not only foretell a patient's prognosis but can also give information directly connected with personalized cancer medicine and prevention...
  47. ncbi Epigenetic inactivation of SOCS-1 by CpG island hypermethylation in human gastric carcinoma
    Yasuhiro Oshimo
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Int J Cancer 112:1003-9. 2004
    ..013 and 0.002, respectively). Our results suggest that transcriptional inactivation of the SOCS-1 gene by hypermethylation may be involved in development, progression and metastasis of GC...
  48. ncbi A single nucleotide polymorphism in the transmembrane domain coding region of HER-2 is associated with development and malignant phenotype of gastric cancer
    Kazuya Kuraoka
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Int J Cancer 107:593-6. 2003
    ..The association of HER-2 genotype with clinicopathologic characteristics of gastric cancer was also suggested, which has to be confirmed with a larger sample size...
  49. ncbi Molecular pathobiology of gastric cancer
    W Yasui
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Minami Ku, Hiroshima, Japan
    Scand J Surg 95:225-31. 2006
    ..g., RegIV and claudin-18 can be identified. Advances in our understanding of the genetic and molecular bases lead to improved diagnosis, personalised medicine and prevention of gastric cancer...
  50. ncbi Alterations of oncogenes in metastatic tumours of human gastric carcinomas
    T Tsujino
    First Department of Pathology, Hiroshima University School of Medicine, Japan
    Br J Cancer 62:226-30. 1990
    ..These results indicate that multi-alterations in oncogenes might occur during tumour progression and metastasis of human gastric carcinomas...
  51. ncbi Clinicopathological significant and prognostic influence of cadherin-17 expression in gastric cancer
    Reiko Ito
    Department of Radiobiology/Molecular Epidemiology, Radiation Effect Research Foundation, 5-2 Hijiyama Park, Minami-ku, Hiroshima, Japan
    Virchows Arch 447:717-22. 2005
    ..These results suggested that the expression of CDH17 was characteristic of the advanced gastric carcinoma that is associated with poor prognosis...
  52. ncbi Molecular characteristics of differentiated-type gastric carcinoma with distinct mucin phenotype: LI-cadherin is associated with intestinal phenotype
    Junichi Motoshita
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Pathol Int 56:200-5. 2006
    ..These results provide insights into the molecular characteristics of the distinct mucin phenotype of differentiated-type GC and suggest that LI-cadherin may contribute to the biological behavior of I-type GC...
  53. ncbi Reduced expression of the TSP1 gene and its association with promoter hypermethylation in gastric carcinoma
    Naohide Oue
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Oncology 64:423-9. 2003
    ..Our results suggest that transcriptional inactivation of TSP1 by aberrant DNA methylation of the promoter region may participate partly in stomach carcinogenesis through TSP1 down-regulation...
  54. ncbi Correlation of a single nucleotide polymorphism in the E-cadherin gene promoter with tumorigenesis and progression of gastric carcinoma in Japan
    Kazuya Kuraoka
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8551, Japan
    Int J Oncol 23:421-7. 2003
    ..05). These results suggest that the C/A SNP in the E-cadherin promoter may be a good marker for malignancy of gastric carcinomas...
  55. ncbi Expression of osteoprotegerin correlates with aggressiveness and poor prognosis of gastric carcinoma
    Reiko Ito
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Japan
    Virchows Arch 443:146-51. 2003
    ..These results suggest that OPG may participate in stomach carcinogenesis, invasion and metastasis, and may serve as a novel molecular marker for aggressive gastric cancer...
  56. ncbi A single nucleotide polymorphism in the MMP-9 promoter affects tumor progression and invasive phenotype of gastric cancer
    Shunji Matsumura
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, 734 8551, Hiroshima, Japan
    J Cancer Res Clin Oncol 131:19-25. 2005
    ..The purpose of this study was to investigate the relation between the -1562 C/T polymorphism and the development and progression of gastric cancer...
  57. ncbi Induction of hRAD9 is required for G2/M checkpoint signal transduction in gastric cancer cells
    Ken Hayashi
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Pathobiology 70:40-6. 2002
    ..These results suggest that besides p53 activity, the induction of hRAD9 is required for G2/M checkpoint signal transduction in gastric cancer cells...
  58. ncbi Primary follicular lymphoma of the gastrointestinal tract: a retrospective case series
    M Kodama
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Endoscopy 40:343-6. 2008
  59. ncbi Small cell carcinoma of the extrahepatic bile duct: case report and immunohistochemical analysis
    Kazuya Kuraoka
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Pathol Int 53:887-91. 2003
    ..Tumor cells showed positive nuclear staining for p16, while negative for cyclin D1, suggesting that functional retinoblastoma protein (pRB) might be lost in the p16/pRB pathway, as in small cell lung cancer...
  60. ncbi Transurethral resection in one piece (TURBO) is an accurate tool for pathological staging of bladder tumor
    Rinzo Ukai
    Department of Urology, Hiroshima General Hospital of West Japan Railway Company, Hiroshima, Japan
    Int J Urol 17:708-14. 2010
    ..To demonstrate the usefulness of transurethral resection in one piece (TURBO) as an accurate pathological staging tool for bladder tumor...
  61. ncbi DNA methylation of multiple genes in gastric carcinoma: association with histological type and CpG island methylator phenotype
    Naohide Oue
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Minami-ku, Hiroshima 734-8551, Japan
    Cancer Sci 94:901-5. 2003
    ....
  62. ncbi DNA methylation profiles of differentiated-type gastric carcinomas with distinct mucin phenotypes
    Junichi Motoshita
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
    Cancer Sci 96:474-9. 2005
    ..These results indicate that DNA methylation of specific genes, such as hMLH1 and MGMT, may be involved partly in the distinct phenotypic expression of GC...
  63. ncbi Frequent epigenetic inactivation of RIZ1 by promoter hypermethylation in human gastric carcinoma
    Yasuhiro Oshimo
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Int J Cancer 110:212-8. 2004
    ..Our results suggest that transcriptional inactivation of the RIZ1 gene by promoter hypermethylation may participate in stomach carcinogenesis...
  64. ncbi No evidence of correlation between the single nucleotide polymorphism of DNMT3B promoter and gastric cancer risk in a Japanese population
    Phyu Phyu Aung
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Oncol Rep 14:1151-4. 2005
    ..Only the T/T genotype was detected in all gastric cancer patients and control subjects. We concluded that there was no association between SNP of the DNMT3B promoter and gastric cancer risk in a Japanese population...
  65. ncbi [Molecular diagnosis of gastric cancer]
    Wataru Yasui
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Nippon Geka Gakkai Zasshi 103:463-7. 2002
    ....
  66. ncbi Tissue remodeling following submassive hemorrhagic necrosis in rat livers induced by an intraperitoneal injection of dimethylnitrosamine
    Yu Lan Jin
    First Department of Pathology, Kochi Medical School, Kohasu, Oko cho, Nankoku City, Kochi, 783 8505, Japan
    Virchows Arch 442:39-47. 2003
    ....
  67. ncbi CD34-positive stromal cells and alpha-smooth muscle actin-positive stromal cells in the tumor capsule of skin sweat gland neoplasms
    Hirofumi Nakayama
    First Department of Pathology, Kochi Medical School, Kochi, Japan
    Pathol Int 52:25-30. 2002
    ....
  68. ncbi Participation of alpha-smooth muscle actin-positive cells in renomedullary interstitial cell tumors
    Naoto Kuroda
    First Department of Pathology, Kochi Medical School, Kohasu, Oko cho, Nankoku City, Kochi 783 8505, Japan
    Oncol Rep 9:745-50. 2002
    ..Furthermore, TGF-beta 1 may contribute to the formation of fibrosis in the tumors...
  69. ncbi Characteristics of normal stromal components and their correlation with cancer occurrence in human prostate
    Yanhu Zhang
    Faculty of Nursing, Kochi Women s University, Kochi City, Japan
    Oncol Rep 10:207-11. 2003
    ..05). The characteristics of stromal components and their amounts in the normal prostate appear to correlate with a distinct predilection for cancer occurrence in the peripheral zone and a weak stromal reaction in prostate cancers...
  70. ncbi Vinculin: a novel marker for quiescent and activated hepatic stellate cells in human and rat livers
    Shuji Kawai
    First Department of Pathology, Kochi Medical School, Kohasu, Oko cho, Nankoku City, 783 8505 Kochi, Japan
    Virchows Arch 443:78-86. 2003
    ..It could allow us to evaluate the development and distribution of quiescent HSCs and to examine the relationship between quiescent and activated HSCs...
  71. ncbi [A case of CA19-9 producing gastric cancer treated by low-dose administration of TS-1 for adjuvant chemotherapy]
    Ikuhiro Takashima
    Dept of Surgery, Hiroshima Mitsubishi Hospital
    Gan To Kagaku Ryoho 32:503-5. 2005
    ..Low-dose administration of TS-1 is thought to be one effective method of postoperative adjuvant chemotherapy for gastric cancer...