Shinya Matsuura

Summary

Affiliation: Hiroshima University
Country: Japan

Publications

  1. ncbi request reprint Nijmegen breakage syndrome and DNA double strand break repair by NBS1 complex
    Shinya Matsuura
    Department of Radiation Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Kasumi 1 2 3, Minami Ku, Hiroshima 734 8553, Japan
    Adv Biophys 38:65-80. 2004
  2. ncbi request reprint Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome
    Shinya Matsuura
    Department of Radiation Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
    Am J Med Genet A 140:358-67. 2006
  3. ncbi request reprint TopBP1 associates with NBS1 and is involved in homologous recombination repair
    Ken ichi Morishima
    Department of Radiation Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
    Biochem Biophys Res Commun 362:872-9. 2007
  4. ncbi request reprint NBS1 and its functional role in the DNA damage response
    Junya Kobayashi
    Department of Oral and Maxillofacial Radiology, Hiroshima University, Hiroshima 734 8553, Japan
    DNA Repair (Amst) 3:855-61. 2004
  5. ncbi request reprint NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain
    Junya Kobayashi
    Department of Oral and Maxillo Facial Radiology, Hiroshima University, Hiroshima 734 8553, Japan
    Curr Biol 12:1846-51. 2002
  6. pmc Zinc-finger nuclease-mediated targeted insertion of reporter genes for quantitative imaging of gene expression in sea urchin embryos
    Hiroshi Ochiai
    Department of Genetics and Cell Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Minami Ku, Hiroshima 734 8553, Japan
    Proc Natl Acad Sci U S A 109:10915-20. 2012
  7. doi request reprint Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly
    Yoshiyuki Matsumoto
    Department of Genetics and Cell Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Kasumi 1 2 3, Hiroshima 734 8553, Japan
    DNA Repair (Amst) 10:314-21. 2011
  8. pmc TALEN-mediated single-base-pair editing identification of an intergenic mutation upstream of BUB1B as causative of PCS (MVA) syndrome
    Hiroshi Ochiai
    Department of Genetics and Cell Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734 8553, Japan
    Proc Natl Acad Sci U S A 111:1461-6. 2014
  9. pmc Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity
    Tetsushi Sakuma
    Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi Hiroshima 739 8526, Japan
    Sci Rep 3:3379. 2013
  10. doi request reprint Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates
    Tatsuo Miyamoto
    Department of Genetics and Cell Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734 8553, Japan
    Hum Mol Genet 20:2058-70. 2011

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Nijmegen breakage syndrome and DNA double strand break repair by NBS1 complex
    Shinya Matsuura
    Department of Radiation Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Kasumi 1 2 3, Minami Ku, Hiroshima 734 8553, Japan
    Adv Biophys 38:65-80. 2004
    ..Further studies on NBS1 will provide insights into the mechanisms of DNA damage response and the network of these factors involved in genomic stability...
  2. ncbi request reprint Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome
    Shinya Matsuura
    Department of Radiation Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
    Am J Med Genet A 140:358-67. 2006
    ..These findings indicate the involvement of BubR1 in p55cdc-mediated mitotic checkpoint signaling, and suggest that >50% decrease in expression (or activity) of BubR1 is involved in the PCS syndrome...
  3. ncbi request reprint TopBP1 associates with NBS1 and is involved in homologous recombination repair
    Ken ichi Morishima
    Department of Radiation Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
    Biochem Biophys Res Commun 362:872-9. 2007
    ..Together, these results suggested that TopBP1 might be a mediator of DNA damage signaling from NBS1 to ATR and promote homologous recombination repair...
  4. ncbi request reprint NBS1 and its functional role in the DNA damage response
    Junya Kobayashi
    Department of Oral and Maxillofacial Radiology, Hiroshima University, Hiroshima 734 8553, Japan
    DNA Repair (Amst) 3:855-61. 2004
    ..This molecular link of NBS1 to ATM may explain the phenotypic similarity of NBS to A-T...
  5. ncbi request reprint NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain
    Junya Kobayashi
    Department of Oral and Maxillo Facial Radiology, Hiroshima University, Hiroshima 734 8553, Japan
    Curr Biol 12:1846-51. 2002
    ..Consequently, the FHA/BRCT domain is likely to have a crucial role for both binding to histone and for relocalization of hMRE11/hRAD50 nuclease complex to the vicinity of DNA damage...
  6. pmc Zinc-finger nuclease-mediated targeted insertion of reporter genes for quantitative imaging of gene expression in sea urchin embryos
    Hiroshi Ochiai
    Department of Genetics and Cell Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Minami Ku, Hiroshima 734 8553, Japan
    Proc Natl Acad Sci U S A 109:10915-20. 2012
    ..These findings demonstrate the feasibility of ZFN-mediated targeted transgene insertion to enable quantification of the expression levels of endogenous genes during development in living sea urchin embryos...
  7. doi request reprint Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly
    Yoshiyuki Matsumoto
    Department of Genetics and Cell Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Kasumi 1 2 3, Hiroshima 734 8553, Japan
    DNA Repair (Amst) 10:314-21. 2011
    ..The translationally silent mutation common to both patients had an effect on splicing efficiency resulting in reduced but normal MRE11 protein. Their levels of radiation-induced activation of ATM were higher than those in ATLD cells...
  8. pmc TALEN-mediated single-base-pair editing identification of an intergenic mutation upstream of BUB1B as causative of PCS (MVA) syndrome
    Hiroshi Ochiai
    Department of Genetics and Cell Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734 8553, Japan
    Proc Natl Acad Sci U S A 111:1461-6. 2014
    ..These results suggested that the nucleotide substitution identified was the causal mutation of PCS (MVA) syndrome. ..
  9. pmc Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity
    Tetsushi Sakuma
    Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi Hiroshima 739 8526, Japan
    Sci Rep 3:3379. 2013
    ..This study therefore demonstrated an efficient system for the construction of these highly active Platinum TALENs (Platinum Gate system), which could establish a new standard in TALEN engineering. ..
  10. doi request reprint Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates
    Tatsuo Miyamoto
    Department of Genetics and Cell Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734 8553, Japan
    Hum Mol Genet 20:2058-70. 2011
    ....
  11. doi request reprint Exome sequencing reveals a novel MRE11 mutation in a patient with progressive myoclonic ataxia
    Ryosuke Miyamoto
    Department of Clinical Neuroscience, Institute of Health Biosciences, Graduate School of Medicine, University of Tokushima, Tokushima, Japan Department of Epidemiology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan Electronic address
    J Neurol Sci 337:219-23. 2014
    ..Moreover, together with a recently reported case of an MRE11 mutation, it is suggested that MRE11 mutations can present as PMA. ..
  12. ncbi request reprint [Smith-Lemli-Opitz syndrome]
    Hiroshi Matsumoto
    Department of Radiation Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University
    Nihon Rinsho . 2006
  13. doi request reprint Efficient TALEN construction and evaluation methods for human cell and animal applications
    Tetsushi Sakuma
    Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, 1 3 1 Kagamiyama, Higashi Hiroshima, Hiroshima 739 8526, Japan
    Genes Cells 18:315-26. 2013
    ..Our methods are more time efficient compared with conventional yeast-based evaluation methods and provide a more accessible and effective protocol for the application of TALENs in various model organisms...
  14. doi request reprint Mutations of optineurin in amyotrophic lateral sclerosis
    Hirofumi Maruyama
    Department of Epidemiology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734 8553, Japan
    Nature 465:223-6. 2010
    ..They also indicate that NF-kappaB inhibitors could be used to treat ALS and that transgenic mice bearing various mutations of OPTN will be relevant in developing new drugs for this disorder...
  15. ncbi request reprint R352Q mutation of the DHCR7 gene is common among Japanese Smith-Lemli-Opitz syndrome patients
    Yoshiyuki Matsumoto
    Department of Radiation Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
    J Hum Genet 50:353-6. 2005
    ..These results suggest that R352Q is a predominant founder mutation in Japanese SLOS patients...
  16. ncbi request reprint Cytoplasmic, but not nuclear, p16 expression may signal poor prognosis in high-grade astrocytomas
    Muhamad Thohar Arifin
    Department of Neurosurgery, Research Institute for Radiation Biology and Medicine, Graduate School of Medical Sciences, Hiroshima University, Hiroshima shi, Japan
    J Neurooncol 77:273-7. 2006
    ..The negative consequences of the cytoplasmic localization of p16 in patients with high-grade astrocytomas, on their prognosis, was investigated...
  17. doi request reprint HpSulf, a heparan sulfate 6-O-endosulfatase, is involved in the regulation of VEGF signaling during sea urchin development
    Kazumasa Fujita
    Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, 1 3 1 Kagamiyama, Higashi Hiroshima 739 8526, Japan
    Mech Dev 127:235-45. 2010
    ..Taken together, these results suggest that HpSulf is involved in the regulation of various signal transductions, including VEGF signaling, during sea urchin development...
  18. ncbi request reprint Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells
    Hiroshi Tauchi
    Department of Environmental Sciences, Faculty of Science, Ibaraki University, Bunkyo 2 1 1, Mito, Ibaraki 310 8512 Japan
    Nature 420:93-8. 2002
    ....
  19. ncbi request reprint Nijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stability
    Hiroshi Tauchi
    Department of Environmental Sciences, Ibaraki University, Mito, Ibaraki 310 8512, Japan
    Oncogene 21:8967-80. 2002
    ..Based on recent knowledge regarding NBS1, we propose here a two-step binding mechanism for damage recognition by repair proteins, and describe the molecular links to factors for genome stability...
  20. ncbi request reprint The Nijmegen breakage syndrome gene and its role in genome stability
    Kenta Iijima
    Department of Environmental Sciences, Faculty of Science, Ibaraki University, Bunkyo 2 1 1, Mito, 310 8512, Ibaraki, Japan
    Chromosoma 113:53-61. 2004
    ..In this review, we describe the role of NBS1 in the maintenance of genetic stability through the activation of cell-cycle checkpoints, DNA repair, and protein relocation...
  21. doi request reprint Combined BubR1 protein down-regulation and RASSF1A hypermethylation in Wilms tumors with diverse cytogenetic changes
    Masayuki Haruta
    Research Institute for Clinical Oncology, Saitama Cancer Center, Ina, Saitama, Japan
    Mol Carcinog 47:660-6. 2008
    ..These findings suggest that the combined BubR1 protein down-regulation and RASSF1A hypermethylation might be implicated in the formation of chromosomal changes found in Wilms tumors...
  22. doi request reprint Absence of Ku70 gene obliterates X-ray-induced lacZ mutagenesis of small deletions in mouse tissues
    Yoshihiko Uehara
    Department of Cell Biology, Graduate School of Medicine, Tohoku University, 2 1 Seiryo machi, Aoba ku, Sendai, Japan
    Radiat Res 170:216-23. 2008
    ..These data indicate a predominant role of non-homologous end joining in the production of radiation-induced mutations in vivo...