Research Topics
Species | Y KudoSummaryAffiliation: Hiroshima University Country: Japan Publications
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Detail Information
Publications
Reduced expression of p27(Kip1) correlates with an early stage of cancer invasion in oral squamous cell carcinomaY Kudo
Department of Oral Pathology, Hiroshima University, Faculty of Dentistry, Hiroshima, Japan
Cancer Lett 151:217-22. 2000..Reduced expression of p27(Kip1) may concern the cancer invasion directly or indirectly as well as abnormal proliferation...- VEGF-C is associated with lymphatic status and invasion in oral cancerB S M S Siriwardena
Department of Oral and Maxillofacial Pathobiology, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
J Clin Pathol 61:103-8. 2008..Recently, it has been revealed that lymphangiogenic growth factor VEGF-C and its receptor Flt-4 play an important role for invasion and metastasis in cancer cells... - High expression of S-phase kinase-interacting protein 2, human F-box protein, correlates with poor prognosis in oral squamous cell carcinomasY Kudo
Department of Oral Pathology, Hiroshima University, Faculty of Dentistry, Hiroshima 734-8553, Japan
Cancer Res 61:7044-7. 2001.... - Inhibition of CD44v9 upregulates the invasion ability of oral squamous cell carcinoma cellsS Sato
Department of Oral Pathology, Hiroshima University, Faculty of Dentistry, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan
Oral Oncol 39:27-30. 2003..It may ultimately promote the establishment of a metastatic lesion... - Clinical and histopathological analyses of desmoplastic ameloblastomaT Takata
Department of Oral Pathology, Hiroshima University School of Dentistry, Japan
Pathol Res Pract 195:669-75. 1999..There was no capsule formation. Recurrence rate was 14% in DA and 20% in non-DA. The present study based on data of DA in the Japanese population supports that DA must be considered as a distinct clinicopathologic entity... - Cytokine expression in rat molar gingival periodontal tissues after topical application of lipopolysaccharideM Miyauchi
Department of Oral Pathology, Hiroshima University Faculty of Dentistry, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8553, Japan
Histochem Cell Biol 116:57-62. 2001.... - Periostin: novel diagnostic and therapeutic target for cancerY Kudo
Department of Oral and Maxillofacial Pathobiology, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
Histol Histopathol 22:1167-74. 2007..This review summarizes the recent understanding of Periostin roles in tumor development and speculates on the usefulness of Periostin as a therapeutic and diagnostic target for cancer... - So-called 'hybrid' lesion of desmoplastic and conventional ameloblastoma: report of a case and review of the literatureT Takata
Department of Oral Pathology, Hiroshima University School of Dentistry, Hiroshima, Japan
Pathol Int 49:1014-8. 1999..Many more cases of 'hybrid' lesion are needed to clarify the clinicopathological, histopathological and biological characteristics of this interesting variant of ameloblastoma... 
Aberrant beta-catenin expression and adenomatous polyposis coli gene mutation in ameloblastoma and odontogenic carcinomaB S M S Siriwardena
Department of Oral Maxillofacial Pathobiology, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734 8553, Japan
Oral Oncol 45:103-8. 2009..Our findings suggest that aberrant beta-catenin expression and APC missense mutation may play an important role for the pathogenesis of epithelial odontogenic tumors...- Immunoexpression of transforming growth factor beta in desmoplastic ameloblastomaT Takata
Department of Oral Pathology, Hiroshima University School of Dentistry, Japan
Virchows Arch 436:319-23. 2000..In the "hybrid" lesion, TGF-beta was not expressed in the area of follicular ameloblastoma but in that of DA. These results show that TGF-beta produced by tumor cells of DA plays a part in the desmoplastic matrix formation... - Immuno-localization of COX-1 and COX-2 in the rat molar periodontal tissue after topical application of lipopolysaccharideM Miyauchi
Division of Frontier Biomedical Science, Department of Oral Maxillofacial Pathobiology, Graduate School of Biomedical Sciences, Hiroshima University, 734-8553, Japan
Arch Oral Biol 49:739-46. 2004..It is suggested that the inducible production of PGE2 via COX-2 by these cells may be associated with connective tissue destruction and alveolar bone resorption... 
Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancerB S M S Siriwardena
Department of Oral Maxillofacial Pathobiology, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Hiroshima, Japan
Br J Cancer 95:1396-403. 2006..In summary, these findings suggest that Periostin may promote invasion and angiogenesis in OSCC, and that Periostin can be a strong marker for prediction of metastasis in oral cancer patients...- Immunohistochemical demonstration of an enamel sheath protein, sheathlin, in odontogenic tumorsT Takata
Department of Oral Pathology, Hiroshima University School of Dentistry, Japan
Virchows Arch 436:324-9. 2000.... - Establishment of mesenchymal cell line derived from human developing odontomaH Hatano
Department of Oral and Maxillofacial Surgery, Division of Cervico Gnathostomatology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
Oral Dis 18:756-62. 2012..These are commonly found in tooth-bearing regions, although the etiology remains unknown. There are no previous reports of an established line of immortalized human odontoma cells... - Establishment of human cementifying fibroma cell lines by transfection with temperature-sensitive simian virus-40 T-antigen gene and hTERT geneY Kudo
Department of Oral Pathology, Faculty of Dentistry, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan
Bone 30:712-7. 2002.... - Diagnostic performance of general dental practitioners after lecture in identifying post-menopausal women with low bone mineral density by panoramic radiographsP Sutthiprapaporn
Department of Oral and Maxillofacial Radiology, Division of Medical Intelligence and Informatics, Hiroshima University, Hiroshima, Japan
Dentomaxillofac Radiol 35:249-52. 2006..0% of women who had low skeletal BMD can be identified by GDPs after a lecture on the use of panoramic radiographs as an aid in diagnosing low BMD; however, the diagnostic performance may not be influenced by GDPs' age... - A computer-aided diagnosis system to screen for osteoporosis using dental panoramic radiographsT Nakamoto
Department of Oral and Maxillofacial Radiology Division of Medical Intelligence and Informatics, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8553, Japan
Dentomaxillofac Radiol 37:274-81. 2008..The purposes of this study were to develop a computer-aided diagnosis (CAD) system that automatically determines cortical erosion of the mandible on dental panoramic radiographs and to assess the validation of this CAD system... - Computer-aided system for measuring the mandibular cortical width on dental panoramic radiographs in identifying postmenopausal women with low bone mineral densityA Z Arifin
Department of Information Engineering, Graduate School of Engineering, Hiroshima University, and Department of Oral and Maxillofacial Radiology, Hiroshima University Hospital, Higashi-Hiroshima, Japan
Osteoporos Int 17:753-9. 2006..5% and about 56.3%, respectively. CONCLUSION: Our results suggest that our computer-aided system may be useful for identifying postmenopausal women with low skeletal BMD... - Observer performance in diagnosing osteoporosis by dental panoramic radiographs: results from the osteoporosis screening project in dentistry (OSPD)A Taguchi
Department of Oral and Maxillofacial Radiology, Hiroshima University Hospital, Hiroshima, Japan
Bone 43:209-13. 2008..Information gathered from radiographic examination is at least as useful as that gathered from the OST index... - An analysis using DNA microarray of the time course of gene expression during syncytialization of a human placental cell line (BeWo)Y Kudo
Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK
Placenta 25:479-88. 2004..Further analysis of this data and expression profiling in general will be able to contribute to understanding the functional basis for the formation of the placental syncytiotrophoblast... - Diagnostic efficacy of alveolar bone loss of the mandible for identifying postmenopausal women with femoral osteoporosisK Ishii
Department of Oral and Maxillofacial Radiology, Hiroshima University Hospital, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
Dentomaxillofac Radiol 36:28-33. 2007..The purpose of this study was to evaluate whether ABL of the mandible on panoramic radiographs is useful for identifying femoral osteoporosis in postmenopausal women in comparison with MCW... - Identification of post-menopausal women at risk of osteoporosis by trained general dental practitioners using panoramic radiographsA Taguchi
Department of Oral and Maxillofacial Radiology, Hiroshima University Hospital, 1 2 3 Kasumi Minami ku, Hiroshima 734 8553, Japan
Dentomaxillofac Radiol 36:149-54. 2007..The purpose of this study was to assess whether trained general dental practitioners (GDPs) can identify post-menopausal women with undetected low skeletal BMD as well as spinal fractures by panoramic radiographs in their clinics... - Changes in expression and function of syncytin and its receptor, amino acid transport system B(0) (ASCT2), in human placental choriocarcinoma BeWo cells during syncytializationY Kudo
Department of Human Anatomy and Genetics, University of Oxford, Oxford, UK
Placenta 23:536-41. 2002.... - Risk of vertebral osteoporosis in post-menopausal women with alterations of the mandibleA Taguchi
Department of Oral and Maxillofacial Radiology, Hiroshima University Hospital, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
Dentomaxillofac Radiol 36:143-8. 2007..However, those studies did not estimate the multivariate-adjusted risk for low vertebral BMD or osteoporosis associated with alterations of the mandible... - Multiple inhibitory pathways for lipopolysaccharide- and pro-inflammatory cytokine-induced nitric oxide production in cultured astrocytesN Kozuka
Laboratory of Cellular Neurobiology, School of Life Science, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, 192 0392 Tokyo, Japan
Neuroscience 144:911-9. 2007..Moreover, these mechanisms provide useful therapeutic targets for the treatment of neurodegenerative diseases... - Growth factors and trophoblast differentiation--workshop reportD W Morrish
Department of Medicine, University of Alberta, 362 Heritage Medical Research Centre, Edmonton, Alberta T6G 2S2, Canada
Placenta 28:S121-4. 2007 - Heterodimeric amino acid transporters in the placenta--a workshop reportT R H Regnault
Department of Obstetrics and Gynaecology, University of Western Ontario, London, Ontario Canada
Placenta 28:S103-6. 2007 - A novel neuroprotective compound FR901459 with dual inhibition of calcineurin and cyclophilinsH Uchino
Department of Anesthesiology, Hachioji Medical Center, Tokyo Medical University, Tokyo, Japan
Acta Neurochir Suppl 96:157-62. 2006..These findings shed light on the clinical application and development of new drugs for the treatment of ischemic damage in the brain as well as in the heart and liver... - Purification and characterization of thrombopoietinT Kato
Pharmaceutical Research Laboratory, Kirin Brewery Co, Ltd, Gunma
J Biochem 118:229-36. 1995..These results indicate that a thrombopoietic factor originally found in the irradiated rat plasma is a ligand for the rat c-Mpl... - Binding assay of low density lipoprotein to Asp-hemolysin from Aspergillus fumigatusY Fukuchi
Japanese Red Cross Sendai Hospital, Japan
Biol Pharm Bull 19:1380-1. 1996..LDL binds to Asp-hemolysin with an affinity as high as the LDL receptor. The apparent Kd, determined by Scatchard plot analysis, was 8.9 x 10(-9) M [125I]LDL. Asp-hemolysin is thus identified as a novel LDL-binding protein... - Cellular localization of thrombopoietin mRNA in the liver by in situ hybridizationS Nomura
Pharmaceutical Research Laboratory, Kirin Brewery Co, Ltd, Gunma, Japan
Exp Hematol 25:565-72. 1997..These results clearly demonstrate that hepatocytes are the primary site of TPO production in the liver from fetus to adult... - Alleic variants of human melatonin 1a receptor: function and prevalence in subjects with circadian rhythm sleep disordersT Ebisawa
Department of Psychiatry, Saitama Medical School, Saitama, Japan
Biochem Biophys Res Commun 262:832-7. 1999.... - Heterodimeric amino acid transporters: expression of heavy but not light chains of CD98 correlates with induction of amino acid transport systems in human placental trophoblastY Kudo
Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK
J Physiol 523:13-8. 2000.... - Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndromeT Ebisawa
Department of Psychiatry, Saitama Medical School, 38 Morohongo, Saitama 350 0495, Japan
EMBO Rep 2:342-6. 2001..037; odds ratio = 7.79; 95% CI 1.59-38.3) in our study population. Our results suggest that structural polymorphisms in the hPer3 gene may be implicated in the pathogenesis of DSPS... - Analysis of codon usage diversity of bacterial genes with a self-organizing map (SOM): characterization of horizontally transferred genes with emphasis on the E. coli O157 genomeS Kanaya
Department of Bio-System Engineering, Faculty of Engineering, Yamagata University, Yonezawa, 992-8510, Yamagata-ken, Japan
Gene 276:89-99. 2001..We used SOM to examine codon usage heterogeneity in the E. coli O157 genome, which contains 'O157-unique segments' (O-islands), and showed that SOM is a powerful tool for characterization of horizontally transferred genes... - Codon usage and tRNA genes in eukaryotes: correlation of codon usage diversity with translation efficiency and with CG-dinucleotide usage as assessed by multivariate analysisS Kanaya
Department of Bio-System Engineering, Faculty of Engineering, Yamagata University, Yonezawa, Yamagata-ken 992-8510, Japan
J Mol Evol 53:290-8. 2001.... - A study of L-leucine, L-phenylalanine and L-alanine transport in the perfused rat mammary gland: possible involvement of LAT1 and LAT2D B Shennan
Hannah Research Institute, Ayr Scotland, UK
Biochim Biophys Acta 1564:133-9. 2002..The finding that L-alanine uptake by the gland was inhibited by BCH suggests that LAT2 may make a significant contribution to neutral amino acid uptake by the mammary epithelium... - Survivin, a potential early predictor of tumor progression in the oral mucosaL Lo Muzio
Institute of Dental Sciences, Faculty of Medicine, University of Ancona, Ancona, Italy
J Dent Res 82:923-8. 2003..High expression of cytoplasmic/nuclear survivin is an early event during oral carcinogenesis and may provide a useful tool for the identification of precancerous lesions at higher risk of progression into invasive carcinoma... - Direct evidence for mutual interactions between perineuronal astrocytes and interneurons in the CA1 region of the rat hippocampusY Yamazaki
Department of Neurophysiology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
Neuroscience 134:791-802. 2005..These results directly demonstrate the existence of bidirectional interactions between neurons and perineuronal astrocytes... - [Two dimensional analysis of neural activities by calcium imaging]Y Kudo
Mitsubishi Kasei Institute of Life Sciences, Tokyo
No To Hattatsu 27:115-22. 1995..Already more than ten years have passed since the first demonstration of a fluorescent Ca2+ indicator, quin 2, and the methods using such Ca2+ indicators become important in the field of experimental biology...