Yasuhiko Kitadai

Summary

Affiliation: Hiroshima University
Country: Japan

Publications

  1. pmc Angiogenesis and lymphangiogenesis of gastric cancer
    Yasuhiko Kitadai
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Oncol 2010:468725. 2010
  2. ncbi request reprint Helicobacter pylori infection influences expression of genes related to angiogenesis and invasion in human gastric carcinoma cells
    Yasuhiko Kitadai
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, 734 8551, Hiroshima, Japan
    Biochem Biophys Res Commun 311:809-14. 2003
  3. ncbi request reprint Quantitative analysis of lymphangiogenic markers for predicting metastasis of human gastric carcinoma to lymph nodes
    Yasuhiko Kitadai
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Int J Cancer 115:388-92. 2005
  4. ncbi request reprint Angiogenic switch occurs during the precancerous stage of human esophageal squamous cell carcinoma
    Yasuhiko Kitadai
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biochemical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Oncol Rep 11:315-9. 2004
  5. ncbi request reprint Expression of hypoxia-inducible factor-1alpha is associated with tumor vascularization in human colorectal carcinoma
    Toshio Kuwai
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Int J Cancer 105:176-81. 2003
  6. doi request reprint Antibodies to Helicobacter pylori and CagA protein are associated with the response to antibacterial therapy in patients with H. pylori-positive API2-MALT1-negative gastric MALT lymphoma
    Tomonori Sumida
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Cancer Sci 100:1075-81. 2009
  7. ncbi request reprint Single nucleotide polymorphism in the hypoxia-inducible factor-1alpha gene in colorectal carcinoma
    Toshio Kuwai
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Hiroshima 734 8551, Japan
    Oncol Rep 12:1033-7. 2004
  8. doi request reprint Vascular endothelial growth factor C stimulates progression of human gastric cancer via both autocrine and paracrine mechanisms
    Michiyo Kodama
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Clin Cancer Res 14:7205-14. 2008
  9. ncbi request reprint Expression of vascular endothelial growth factor and angiogenesis in gastrointestinal stromal tumor of the stomach
    Ryoji Takahashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Oncology 64:266-74. 2003
  10. doi request reprint Anti-stromal therapy with imatinib inhibits growth and metastasis of gastric carcinoma in an orthotopic nude mouse model
    Tomonori Sumida
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Minami Ku, Hiroshima, Japan
    Int J Cancer 128:2050-62. 2011

Collaborators

Detail Information

Publications84

  1. pmc Angiogenesis and lymphangiogenesis of gastric cancer
    Yasuhiko Kitadai
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Oncol 2010:468725. 2010
    ..We review the current understanding of molecular mechanisms involved in angiogenesis and lymphangiogenesis of human gastric cancer...
  2. ncbi request reprint Helicobacter pylori infection influences expression of genes related to angiogenesis and invasion in human gastric carcinoma cells
    Yasuhiko Kitadai
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, 734 8551, Hiroshima, Japan
    Biochem Biophys Res Commun 311:809-14. 2003
    ..pylori. These results indicate that H. pylori infection may regulate angiogenesis and invasion of human gastric carcinoma...
  3. ncbi request reprint Quantitative analysis of lymphangiogenic markers for predicting metastasis of human gastric carcinoma to lymph nodes
    Yasuhiko Kitadai
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Int J Cancer 115:388-92. 2005
    ..These results indicate that quantitative analysis of lymphangiogenic markers in gastric biopsy specimens may be useful in predicting metastasis of gastric cancer to regional lymph nodes...
  4. ncbi request reprint Angiogenic switch occurs during the precancerous stage of human esophageal squamous cell carcinoma
    Yasuhiko Kitadai
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biochemical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Oncol Rep 11:315-9. 2004
    ..Several different angiogenic factors produced by tumor cells and host cells may regulate angiogenesis during different steps of esophageal carcinogenesis...
  5. ncbi request reprint Expression of hypoxia-inducible factor-1alpha is associated with tumor vascularization in human colorectal carcinoma
    Toshio Kuwai
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Int J Cancer 105:176-81. 2003
    ..These findings suggest that HIF-1alpha may play a role in angiogenesis and tumor progression via regulation of VEGF in human colorectal carcinoma...
  6. doi request reprint Antibodies to Helicobacter pylori and CagA protein are associated with the response to antibacterial therapy in patients with H. pylori-positive API2-MALT1-negative gastric MALT lymphoma
    Tomonori Sumida
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Cancer Sci 100:1075-81. 2009
    ..In conclusion, measurement of titers of serum antibodies to H. pylori and CagA protein may be useful for predicting the response to eradication therapy in patients with H. pylori-positive API2-MALT1-negative gastric MALT lymphoma...
  7. ncbi request reprint Single nucleotide polymorphism in the hypoxia-inducible factor-1alpha gene in colorectal carcinoma
    Toshio Kuwai
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Hiroshima 734 8551, Japan
    Oncol Rep 12:1033-7. 2004
    ..0005). These results suggest that the C1772T polymorphism in HIF-1alpha is not involved in progression or metastasis of colorectal carcinoma...
  8. doi request reprint Vascular endothelial growth factor C stimulates progression of human gastric cancer via both autocrine and paracrine mechanisms
    Michiyo Kodama
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Clin Cancer Res 14:7205-14. 2008
    ..VEGFR-3 has also been detected on several malignant cells, but the significance of VEGFR-3 expression on malignant cells remains unclear. In this study, we examined the expression and function of VEGFR-3 in gastric carcinoma cells...
  9. ncbi request reprint Expression of vascular endothelial growth factor and angiogenesis in gastrointestinal stromal tumor of the stomach
    Ryoji Takahashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Oncology 64:266-74. 2003
    ..The aim of this study was to elucidate the clinical significance of VEGF expression in gastrointestinal stromal tumor (GIST)...
  10. doi request reprint Anti-stromal therapy with imatinib inhibits growth and metastasis of gastric carcinoma in an orthotopic nude mouse model
    Tomonori Sumida
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Minami Ku, Hiroshima, Japan
    Int J Cancer 128:2050-62. 2011
    ..In conclusion, administration of PDGF-R tyrosine kinase inhibitor in combination with irinotecan appears to impair the progressive growth of gastric carcinoma by blockade of PDGF-R signaling pathways in stromal cells...
  11. doi request reprint Stroma-directed imatinib therapy impairs the tumor-promoting effect of bone marrow-derived mesenchymal stem cells in an orthotopic transplantation model of colon cancer
    Kei Shinagawa
    Department of Gastroenterology and Metabolism, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Int J Cancer 132:813-23. 2013
    ..Our data suggest that blockade of PDGF signaling pathways influences the interaction between bone marrow-derived MSCs and tumor cells in the tumor microenvironment and, hence, inhibits the progressive growth of colon cancer...
  12. ncbi request reprint Monocyte chemoattractant protein-1 transfection induces angiogenesis and tumorigenesis of gastric carcinoma in nude mice via macrophage recruitment
    Tsuyoshi Kuroda
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences and Health Service Center, Hiroshima University, Japan
    Clin Cancer Res 11:7629-36. 2005
    ..The present study was undertaken to obtain direct evidence that MCP-1 participates in recruitment of macrophages and induction of angiogenesis...
  13. ncbi request reprint DNA demethylation of vascular endothelial growth factor-C is associated with gene expression and its possible involvement of lymphangiogenesis in gastric cancer
    Shunji Matsumura
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Int J Cancer 120:1689-95. 2007
    ..0001). These results suggest that demethylation and activation of the VEGF-C gene is likely involved in lymphangiogenesis in GC...
  14. ncbi request reprint A single nucleotide polymorphism in the MMP-9 promoter affects tumor progression and invasive phenotype of gastric cancer
    Shunji Matsumura
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, 734 8551, Hiroshima, Japan
    J Cancer Res Clin Oncol 131:19-25. 2005
    ..The purpose of this study was to investigate the relation between the -1562 C/T polymorphism and the development and progression of gastric cancer...
  15. ncbi request reprint Genetic and pathologic characteristics of gastrointestinal stromal tumors in extragastric lesions
    Songde Cho
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8551, Japan
    Int J Mol Med 18:1067-71. 2006
    ..These data suggest that extragastric GISTs differ from gastric GISTs with respect to associated mutations and angiogenic activity...
  16. ncbi request reprint Clinical significance of angiopoietin-2 expression at the deepest invasive tumor site of advanced colorectal carcinoma
    Takehiko Ochiumi
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biochemical Research, Graduated School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Int J Oncol 24:539-47. 2004
    ....
  17. ncbi request reprint Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human gastric carcinomas
    Masahiro Ohta
    Department of Medicine and Molecular Science, Hiroshima University, Hiroshima, Japan
    Int J Oncol 22:773-8. 2003
    ..These results suggest that MCP-1 produced by human gastric carcinoma cells plays a role in angiogenesis via macrophage recruitment and activation...
  18. ncbi request reprint A single nucleotide polymorphism in the MMP-1 promoter is correlated with histological differentiation of gastric cancer
    Shunji Matsumura
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima, Japan
    J Cancer Res Clin Oncol 130:259-65. 2004
    ..In the light of these findings, we investigated whether this SNP in the MMP-1 promoter is associated with the development, differentiation, and progression of gastric cancer...
  19. ncbi request reprint Epigenetic inactivation of SOCS-1 by CpG island hypermethylation in human gastric carcinoma
    Yasuhiro Oshimo
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Int J Cancer 112:1003-9. 2004
    ..013 and 0.002, respectively). Our results suggest that transcriptional inactivation of the SOCS-1 gene by hypermethylation may be involved in development, progression and metastasis of GC...
  20. ncbi request reprint Clinical significance of thrombospondin-1 expression in relation to vascular endothelial growth factor and interleukin-10 expression at the deepest invasive tumor site of advanced colorectal carcinoma
    Eijiro Kaio
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biochemical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Int J Oncol 23:901-11. 2003
    ..Although lack of TSP-1 or IL-10 expression was associated significantly with poorer prognosis, this may be less important in poorer prognosis than the presence of VEGF expression...
  21. doi request reprint Potential role for vascular endothelial growth factor-D as an autocrine factor for human gastric carcinoma cells
    Miwako Tanaka
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Cancer Sci 101:2121-7. 2010
    ..VEGF-D may participate in the progression of human gastric carcinoma by acting via autocrine and paracrine mechanisms...
  22. ncbi request reprint Clinical significance of angiogenic factor expression at the deepest invasive site of advanced colorectal carcinoma
    Eijiro Kaio
    The First Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima, Japan
    Oncology 64:61-73. 2003
    ..Of the several angiogenic factors, VEGF expression at the deepest invasive site of tumor was the most statistically significant indicator of prognosis in advanced CRC...
  23. ncbi request reprint A single nucleotide polymorphism in the 5' untranslated region of the EGF gene is associated with occurrence and malignant progression of gastric cancer
    Yoichi Hamai
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Pathobiology 72:133-8. 2005
    ..We examined whether this polymorphism is correlated with the development and malignant phenotypes of gastric cancer...
  24. ncbi request reprint Expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in early gastric carcinoma: correlation with clinicopathological parameters
    Seiji Onogawa
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Cancer Lett 226:85-90. 2005
    ..No association was identified between VEGF-D immunoreactivity and clinicopathological variables. These results suggest that VEGF-C is a dominant regulator of lymphangiogenesis in early-stage human gastric carcinoma...
  25. ncbi request reprint Frequent loss of RUNX3 expression by promoter hypermethylation in gastric carcinoma
    Yasuhiro Oshimo
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Pathobiology 71:137-43. 2004
    ..Our results overall suggest that transcriptional inactivation of RUNX3 by promoter hypermethylation may participate in the stomach carcinogenesis...
  26. ncbi request reprint Expression of hypoxia-inducible factor (HIF)-1alpha is associated with vascular endothelial growth factor expression and tumour angiogenesis in human oesophageal squamous cell carcinoma
    Shigeru Kimura
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Eur J Cancer 40:1904-12. 2004
    ..These results suggest that HIF-1alpha and VEGF expression are important determinants of survival in squamous cell carcinoma of the oesophagus...
  27. ncbi request reprint Presence of poorly differentiated component correlated with submucosal invasion in the early diffuse-type gastric cancer
    Tsuyoshi Kuroda
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Hepatogastroenterology 55:2264-8. 2008
    ..The aim of this study is to distinguish the behaviors of early diffuse-type gastric carcinomas by sub classifying tumors according to their histologic features...
  28. ncbi request reprint Hypoxia-inducible factor-1alpha expression and angiogenesis in gastrointestinal stromal tumor of the stomach
    Ryoji Takahashi
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan
    Oncol Rep 10:797-802. 2003
    ..HIF-1alpha may play a role in angiogenesis and tumor progression of GIST through regulation of VEGF...
  29. ncbi request reprint Correlation of a single nucleotide polymorphism in the E-cadherin gene promoter with tumorigenesis and progression of gastric carcinoma in Japan
    Kazuya Kuraoka
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8551, Japan
    Int J Oncol 23:421-7. 2003
    ..05). These results suggest that the C/A SNP in the E-cadherin promoter may be a good marker for malignancy of gastric carcinomas...
  30. ncbi request reprint Deletion of the KIT gene is associated with liver metastasis and poor prognosis in patients with gastrointestinal stromal tumor in the stomach
    Songde Cho
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Minami Ku, Hiroshima 734 8551, Japan
    Int J Oncol 28:1361-7. 2006
    ..Our data indicate that KIT mutations, especially deletions in exon 11, are markers of poor prognosis for gastric GISTs...
  31. ncbi request reprint Expression of VEGF-C and VEGF-D at the invasive edge correlates with lymph node metastasis and prognosis of patients with colorectal carcinoma
    Seiji Onogawa
    Department of Medicine, Hiroshima University Graduate School of Biomedical Science, Minami Ku, Hiroshima 734 8551, Japan
    Cancer Sci 95:32-9. 2004
    ..These results suggest that VEGF-C and VEGF-D may be independent and important prognostic factors in patients with human colorectal carcinoma...
  32. ncbi request reprint Expression of p53 protein in esophageal squamous cell carcinoma: relation to hypoxia-inducible factor-1alpha, angiogenesis and apoptosis
    Shigeru Kimura
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Pathobiology 72:179-85. 2005
    ..p53 has been reported to interact with HIF-1alpha and induce ubiquitin-mediated proteosomal degradation of HIF-1alpha. The purpose of this study was to clarify whether the expression of p53 is associated with that of HIF-1alpha...
  33. ncbi request reprint Frequent loss of heterozygosity on chromosome 10p14-p15 in esophageal dysplasia and squamous cell carcinoma
    Hideyuki Shima
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Program for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Minami Ku, Hiroshima 734 8551, Japan
    Oncol Rep 12:333-7. 2004
    ..These data suggest that a putative tumor suppressor gene for esophageal carcinogenesis may be located on chromosome 10p14-p15 and that malfunction of this gene may be involved in the development but not progression of esophageal tumors...
  34. ncbi request reprint Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human esophageal squamous cell carcinomas
    Masahiro Ohta
    Department of Medicine and Molecular Science, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Int J Cancer 102:220-4. 2002
    ..These results suggest that interactions between cancer cells and macrophages are important for tumor angiogenesis. MCP-1 may play a role in progression of human esophageal carcinoma through its role in angiogenesis...
  35. ncbi request reprint p53 Codon 72 polymorphism in gastric cancer susceptibility in patients with Helicobacter pylori-associated chronic gastritis
    Toru Hiyama
    First Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima, Japan
    Int J Cancer 100:304-8. 2002
    ..pylori-CG. The p53 codon 72 polymorphism may serve as the genetic marker for the risk assessment of the diffuse-type gastric cancer development in patients with H. pylori-CG...
  36. doi request reprint Mesenchymal stem cells enhance growth and metastasis of colon cancer
    Kei Shinagawa
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Int J Cancer 127:2323-33. 2010
    ..Collectively, MSCs migrate and differentiate into CAFs in tumor stroma, and they promote growth and metastasis of colon cancer by enhancing angiogenesis, migration and invasion and by inhibiting apoptosis of tumor cells...
  37. ncbi request reprint Laminin gamma2 mediates Wnt5a-induced invasion of gastric cancer cells
    Hideki Yamamoto
    Department of Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Gastroenterology 137:242-52, 252.e1-6. 2009
    ..The aim of this study was to show that Wnt5a is involved in metastasis of gastric cancer cells in vivo and to explore the molecular mechanism by which Wnt5a regulates migration and invasion...
  38. ncbi request reprint Frequent epigenetic inactivation of RIZ1 by promoter hypermethylation in human gastric carcinoma
    Yasuhiro Oshimo
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Int J Cancer 110:212-8. 2004
    ..Our results suggest that transcriptional inactivation of the RIZ1 gene by promoter hypermethylation may participate in stomach carcinogenesis...
  39. ncbi request reprint Clinical significance of Fhit expression in development of colorectal carcinoma of various macroscopic types
    Toshio Kuwai
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Hiroshima University, Graduate School of Biomedical Sciences, Hiroshima, Japan
    Int J Mol Med 12:437-42. 2003
    ..01). The present findings suggest that reduced expression of Fhit protein is related to development of colorectal neoplasm. Polypoid CRC and G-LST appear to differ from superficial depressed CRC in terms of Fhit expression...
  40. ncbi request reprint Neuropilin-1 is involved in regulation of apoptosis and migration of human colon cancer
    Takehiko Ochiumi
    Department of Medicine and Molecular Science, Graduated School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Int J Oncol 29:105-16. 2006
    ..NP-1 expression may stimulate tumor growth by enhanced angiogenesis and suppression of tumor cell apoptosis, which lead to metastasis and poor prognosis...
  41. ncbi request reprint Immune response to CagA protein is associated with improved platelet count after Helicobacter pylori eradication in patients with idiopathic thrombocytopenic purpura
    Michiyo Kodama
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Helicobacter 12:36-42. 2007
    ..pylori eradication therapy...
  42. ncbi request reprint A water-soluble extract from culture medium of Ganoderma lucidum mycelia suppresses the development of colorectal adenomas
    Shiro Oka
    Department of Endoscopy, Hiroshima University Hospital, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Hiroshima J Med Sci 59:1-6. 2010
    ..73 +/- 0.28 mm in the control group and decreased to -1.40 +/- 0.64 mm in the MAK group (p < 0.01). The resultssuggest that MAK suppresses the development of colorectal adenomas - precancerous lesions of the large bowel...
  43. ncbi request reprint Promoter methylation of cyclin D2 gene in gastric carcinoma
    Yasuhiro Oshimo
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8551, Japan
    Int J Oncol 23:1663-70. 2003
    ..These results suggest that DNA hypomethylation is a mechanism underlying the increased expression of cyclin D2 in cancer cells and that demethylation of cyclin D2 may be involved in development and progression of gastric carcinoma...
  44. ncbi request reprint Involvement of proinflammatory cytokines IL-1beta and IL-6 in progression of human gastric carcinoma
    Hirohisa Kai
    Department of Medicine and Molecular Science, Hiroshima University, Graduate School of Biomedical Sciences, Hiroshima, Japan
    Anticancer Res 25:709-13. 2005
    ..Gastric carcinoma occurs in response to chronic inflammation of gastric mucosa infected with Helicobacter pylori. It is not known how cytokines affect the growth and progression of gastric carcinoma...
  45. ncbi request reprint Mutation of the von Hippel-Lindau (VHL) gene in human colorectal carcinoma: association with cytoplasmic accumulation of hypoxia-inducible factor (HIF)-1alpha
    Toshio Kuwai
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima University Hospital, Minami Ku, Hiroshima, 734 8551, Japan
    Cancer Sci 95:149-53. 2004
    ..8%, P < 0.05). These findings suggest that mutations in VHL may play a role in colorectal carcinoma via activation of the HIF-related transcriptional cascade...
  46. ncbi request reprint Mucin phenotype and background mucosa of intramucosal differentiated-type adenocarcinoma of the stomach
    Atsunori Sasaki
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University Hospital, Hiroshima, Japan
    Oncology 66:379-87. 2004
    ..In this study, we investigated the clinicopathological features of differentiated-type adenocarcinomas and evaluated the background mucosa of the stomach based on mucin expression by the tumors...
  47. doi request reprint Expression of platelet-derived growth factor (PDGF)-B and PDGF-receptor β is associated with lymphatic metastasis in human gastric carcinoma
    Michiyo Kodama
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Cancer Sci 101:1984-9. 2010
    ..Blockade of PDGF-R signaling pathways may inhibit lymph node metastasis of gastric carcinoma...
  48. ncbi request reprint Clinicopathologic features and endoscopic resection of early primary nonampullary duodenal carcinoma
    Shiro Oka
    Department of Endoscopy, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Clin Gastroenterol 37:381-6. 2003
    ..Endoscopic resection appears to be a safe and efficient treatment of carefully selected patients with early primary nonampullary duodenal carcinoma...
  49. ncbi request reprint Expression of human telomerase reverse transcriptase mRNA in esophageal cancers and precancerous lesions
    Toru Amioka
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biochemical Sciences, Hiroshima, Japan
    Oncol Rep 11:51-5. 2004
    ..These results suggest that overexpression of hTERT mRNA may be correlated with proliferative activity reflected by Ki-67 immunoreactivity and is an early event in carcinogenesis of the esophagus...
  50. ncbi request reprint Determining depth of invasion by VN pit pattern analysis in submucosal colorectal carcinoma
    Shinji Tanaka
    Department of Endoscopy, Hiroshima University Medical Hospital, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Oncol Rep 9:1005-8. 2002
    ..In submucosal colorectal carcinoma of the superficial or broad based sessile polypoid type in gross appearance, measurement of the maximum VN pit-pattern area diameter allows estimation of the depth of submucosal invasion...
  51. ncbi request reprint Clinicopathologic and endoscopic features of colorectal serrated adenoma: differences between polypoid and superficial types
    Shiro Oka
    Department of Endoscopy, Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Gastrointest Endosc 59:213-9. 2004
    ..There are two macroscopic types: polypoid and superficial. The aim of this study was to clarify clinicopathologic and endoscopic differences between polypoid and superficial serrated adenomas...
  52. ncbi request reprint A combination of the Helicobacter pylori stool antigen test and urea breath test is useful for clinical evaluation of eradication therapy: a multicenter study
    Masanori Ito
    Department of Medicine and Molecular Science, Hirsohima University, Hiroshima 734 8551, Japan
    J Gastroenterol Hepatol 20:1241-5. 2005
    ..pylori infection. The present study was carried out to investigate the clinical usefulness of the HpSA test in the evaluation of eradication therapy by comparing it with the (13)C-urea breath test (UBT)...
  53. ncbi request reprint Reduced expression of the TSP1 gene and its association with promoter hypermethylation in gastric carcinoma
    Naohide Oue
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Oncology 64:423-9. 2003
    ..Our results suggest that transcriptional inactivation of TSP1 by aberrant DNA methylation of the promoter region may participate partly in stomach carcinogenesis through TSP1 down-regulation...
  54. ncbi request reprint Effects of aged garlic extract (AGE) on colorectal adenomas: a double-blinded study
    Shinji Tanaka
    Department of Endoscopy, Hiroshima University Hospital, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8551, Japan
    Hiroshima J Med Sci 53:39-45. 2004
    ..03). The results of this study suggest the possibility of preventive and therapeutic effects of AGE on colorectal adenomas, though it is necessary to investigate these in larger-scale and longer-term trials...
  55. ncbi request reprint Expression of thrombospondin-1 is correlated with microvessel density in gastric carcinoma
    Jie Zhang
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 734 8551, Hiroshima, Japan
    Virchows Arch 442:563-8. 2003
    ..Our results support an idea that increased TSP-1 expression may be associated with an angiogenic phenotype in gastric carcinoma and suggest that TSP-1 may play diverse roles in each organ...
  56. ncbi request reprint Magnifying colonoscopic features of ulcerative colitis reflect histologic inflammation
    Masaki Kunihiro
    Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan
    Inflamm Bowel Dis 10:737-44. 2004
    ..The aim of this study was to clarify the relation between magnifying colonoscopic features and histologic inflammation in the course of ulcerative colitis...
  57. ncbi request reprint Small rectal carcinoid with lymph node metastasis diagnosed prior to treatment
    Seiji Onogawa
    Department of Endoscopy, Hiroshima University School of Medicine, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Eur J Gastroenterol Hepatol 15:195-7. 2003
    ..Even with a small carcinoid, it is important to determine the depth of invasion and the presence of lymph node metastasis prior to treatment...
  58. ncbi request reprint Basis of decreased risk of gastric cancer in severe atrophic gastritis with eradication of Helicobacter pylori
    Akira Tari
    Department of Internal Medicine, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, 1 9 6 Senda machi, Hiroshima, 730 8619, Japan
    Dig Dis Sci 52:232-9. 2007
    ..pylori eradication decreases the nitrosation rate as the ratio of vitamin C to nitrite increases. This decreases reactive oxygen species and nitric oxide, eliminating their damaging effect on DNA and reducing cell turnover...
  59. ncbi request reprint Cavernous hemangioma in the ascending colon treated by endoscopic mucosal resection
    Shigeru Kimura
    Department of Endoscopy, School of Medicine, Hiroshima University, Hiroshima, Japan
    J Gastroenterol Hepatol 22:280-1. 2007
    ..The case is reported of a patient with a formed, sessile, polypoid-type cavernous hemangioma in the ascending colon that was removed successfully by endoscopic mucosal resection...
  60. doi request reprint Predictive value of endoscopy and endoscopic ultrasonography for regression of gastric diffuse large B-cell lymphomas after Helicobacter pylori eradication
    Akira Tari
    Sixth Department of Internal Medicine, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, Naka ku, Hiroshima, Japan
    Dig Endosc 21:219-27. 2009
    ..pylori eradication...
  61. ncbi request reprint Clinical significance of vascular endothelial growth factor C expression and angiogenesis at the deepest invasive site of advanced colorectal carcinoma
    Akira Furudoi
    First Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima, Japan
    Oncology 62:157-66. 2002
    ..The aim of this study was to elucidate the clinical significance of VEGF-C expression and microvessel density (MVD) at the deepest invasive site in advanced colorectal carcinoma (CRC)...
  62. ncbi request reprint Regulation of vascular endothelial growth factor (VEGF)-C and VEGF-D expression by the organ microenvironment in human colon carcinoma
    Seiji Onogawa
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Eur J Cancer 40:1604-9. 2004
    ..These data suggest that the expression of lymphangiogenic factors is influenced by the organ microenvironment. Therefore, experimental studies of colon cancer lymphangiogenesis should be performed with orthotopic implantation models...
  63. ncbi request reprint Clinical significance of angiogenesis in rectal carcinoid tumors
    Seiji Onogawa
    Department of Endoscopy, Hiroshima University School of Medicine, Hiroshima 734 8551, Japan
    Oncol Rep 9:489-94. 2002
    ..Rectal carcinoid tumors are slow-growing tumors with a lower proliferative activity. Angiogenesis plays an important role in progression of rectal carcinoid tumors independent of the cellular proliferative activity...
  64. ncbi request reprint The promoter methylation status of the DNA repair gene O6-methylguanine-DNA methyltransferase in ulcerative colitis
    Shunji Matsumura
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, 734 8551 Hiroshima, Japan
    Virchows Arch 443:518-23. 2003
    ..A different genetic pathway for tumor progression may exist between sporadic CRC and UC-associated CRC...
  65. ncbi request reprint Infliximab therapy for Crohn's disease in a patient with chronic hepatitis B
    Yoshitaka Ueno
    Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan
    Dig Dis Sci 50:163-6. 2005
  66. ncbi request reprint Potential involvement of IL-8 and its receptors in the invasiveness of pancreatic cancer cells
    Yukio Kuwada
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8551, Japan
    Int J Oncol 22:765-71. 2003
    ..These results demonstrate that IL-8 and IL-8 receptors are over-expressed in pancreatic cancer, and suggest that IL-8 regulates MMP-2 activity and plays an important role in the invasiveness of human pancreatic cancer...
  67. ncbi request reprint K-ras mutation in helicobacter pylori-associated chronic gastritis in patients with and without gastric cancer
    Toru Hiyama
    First Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima, Japan
    Int J Cancer 97:562-6. 2002
    ....
  68. ncbi request reprint Initial experience with catheter probe US when using a multibending endoscope
    Shigeto Yoshida
    Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan
    Gastrointest Endosc 59:889-94. 2004
    ..A multibending endoscope has been developed that has two bending sections that can be deflected independently. The aim of this study was to determine whether this new endoscope enhances high-frequency catheter probe US...
  69. ncbi request reprint Is apoptosis in antral mucosa correlated with serum nitrite concentration in Japanese Helicobacter pylori-infected patients?
    Akira Tari
    Department of Internal Medicine, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, Hiroshima, Japan
    J Gastroenterol Hepatol 18:498-504. 2003
    ..Nitric oxide produced by these cells infiltrating the gastric mucosa could damage DNA. We correlated apoptosis in H. pylori-infected antral tissue from peptic ulcer patients with serum nitrate-plus-nitrite...
  70. ncbi request reprint Somatic mutation of mitochondrial DNA in Helicobacter pylori-associated chronic gastritis in patients with and without gastric cancer
    Toru Hiyama
    Health Service Center, Hiroshima University, Higashihiroshima 739 8521, Japan
    Int J Mol Med 12:169-74. 2003
    ..4%, p<0.001). These data suggest that somatic mutations of the mtDNA may be involved in the early stages of gastric carcinogenesis...
  71. ncbi request reprint Somatic mutation in mitochondrial DNA and nuclear microsatellite instability in gastric cancer
    Toru Hiyama
    Health Service Center, Hiroshima University, Higashihiroshima 739 8521, Japan
    Oncol Rep 10:1837-41. 2003
    ..These results suggest that somatic mutations in the mtDNA and nuclear MSI-H play important roles in gastric carcinogenesis, and that mtDNA mutations may not be associated with nuclear MSI-H in gastric cancers...
  72. ncbi request reprint Prevalence of Helicobacter pylori resistance to clarithromycin and metronidazole determined by 23S ribosomal RNA and rdxA gene analyses in Hiroshima, Japan
    Toru Hiyama
    Health Service Center, Hiroshima University, Higashihiroshima, Japan
    J Gastroenterol Hepatol 18:1202-7. 2003
    ..pylori. The prevalence of H. pylori infections that are resistant to clarithromycin, metronidazole, or both were determined in H. pylori isolates in Hiroshima, Japan...
  73. ncbi request reprint p53 expression, K-ras gene mutation and microsatellite instability in gastric B-cell lymphomas
    Toru Hiyama
    Health Service Center, Hiroshima University, 1 7 1 Kagamiyama, Higashihiroshima 739 8521, Japan
    J Gastroenterol Hepatol 18:1047-53. 2003
    ..The aim of the present study was to clarify the roles of mutations of the p53 and K-ras genes, and microsatellite instability (MSI) in the development of gastric B-cell lymphomas...
  74. ncbi request reprint Frequent loss of heterozygosity on chromosome 10p15, a putative telomerase repressor/senescence gene locus, in gastric cancer
    Toru Hiyama
    Health Service Center, Hiroshima University, Higashihiroshima 739 8521, Japan
    Oncol Rep 10:1297-9. 2003
    ....
  75. ncbi request reprint Chromosomal and microsatellite instability in sporadic gastric cancer
    Toru Hiyama
    Health Service Center, Hiroshima University, Higashihiroshima, Japan
    J Gastroenterol Hepatol 19:756-60. 2004
    ..It is hypothesized that these two pathways are not always independent and that some tumors show overlap between these two mechanisms...
  76. ncbi request reprint Helicobactor pylori infection is closely associated with telomere reduction in gastric mucosa
    Hiroki Kuniyasu
    Department of Oncological Pathology, Cancer Center, Nara Medical University, Kashihara, Japan
    Oncology 65:275-82. 2003
    ..To investigate differential reduction in telomere DNA in tissue components of gastric mucosa with respect to Helicobactor pylori infection...
  77. ncbi request reprint [The analysis of the recurrence ulcer after H. pylori eradication]
    Tomoari Kamada
    First Department of Internal Medicine, Hiroshima University School of Medicine
    Nihon Rinsho 60:501-5. 2002
  78. ncbi request reprint Multiparametric in situ mRNA hybridization analysis of gastric biopsies predicts lymph node metastasis in patients with gastric carcinoma
    Yutaka Takahashi
    Department of Surgical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa 920 8640, Japan
    Jpn J Cancer Res 93:1258-65. 2002
    ..These results suggest that multiparametric in situ hybridization analysis for several metastasis-related genes may allow the preoperative prediction of lymph node metastasis from gastric cancer...
  79. ncbi request reprint Production of interleukin 15 by human colon cancer cells is associated with induction of mucosal hyperplasia, angiogenesis, and metastasis
    Hiroki Kuniyasu
    Department of Oncological Pathology, Nara Medical University Cancer Center, Kashihara, Nara 634 8521, Japan
    Clin Cancer Res 9:4802-10. 2003
    ..The purpose of this study was to identify a mediator produced by human colon cancer cells that is responsible for the induction of hyperplasia in the adjacent mucosa...
  80. ncbi request reprint Epstein-Barr virus involvement is a predictive factor for the resistance to chemoradiotherapy of gastric diffuse large B-cell lymphoma
    Tadashi Yoshino
    Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, 2 5 1, Shikata cho, Okayama 700 8558, Japan
    Cancer Sci 97:163-6. 2006
    ..This finding strongly indicated that EBV-associated gastric diffuse large B-cell lymphomas frequently show resistance to standard chemoradiotherapy, although some other adverse factors remain unclear...
  81. ncbi request reprint Significance of an exaggerated meal-stimulated gastrin response in pathogenesis of Helicobacter pylori-negative duodenal ulcer
    Tomoari Kamada
    Division of Gastroenterology, Department of Medicine, Kawasaki Medical School, Matsushima, Kurashiki, Japan
    Dig Dis Sci 48:644-51. 2003
    ..3%) with H. pylori-negative DU. In conclusion, our findings indicate that an exaggerated meal-stimulated gastrin response may contribute to the pathogenesis of H. pylori-negative DU...
  82. ncbi request reprint [Non-ulcer dyspepsia and H. pylori]
    Tomoari Kamada
    First Department of Internal Medicine, Hiroshima University School of Medicine
    Nihon Rinsho 60:774-8. 2002
  83. pmc Targeting the expression of platelet-derived growth factor receptor by reactive stroma inhibits growth and metastasis of human colon carcinoma
    Yasuhiko Kitadai
    Department of Cancer Biology, Unit 173, The University of Texas M D Anderson Cancer Center, P O Box 302429, Houston, TX 77230 1429, USA
    Am J Pathol 169:2054-65. 2006
    ..These data demonstrate that blockade of PDGF-R signaling pathways in tumor-associated stromal cells and pericytes inhibits the progressive growth and metastasis of colon cancer cells...