Research Topics
Genomes and Genes
| A KikuchiSummaryAffiliation: Hiroshima University Country: Japan Publications
| Collaborators
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Detail Information
Publications
Roles of Axin in the Wnt signalling pathwayA Kikuchi
Department of Biochemistry, Hiroshima University School of Medicine, Kasumi, Minami Ku, Japan
Cell Signal 11:777-88. 1999..Thus, Axin acts as a scaffold protein in the Wnt signalling pathway, thereby regulating cellular functions...- Modulation of Wnt signaling by Axin and AxilA Kikuchi
Department of Biochemistry, Hiroshima University School of Medicine, Japan
Cytokine Growth Factor Rev 10:255-65. 1999..Axil has similar functions to Axin. Thus, Axin and Axil act as scaffold proteins in the Wnt signaling pathway, thereby modulating the Wnt-dependent cellular functions... 
Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding proteinS Hino
Department of Biochemistry, Hiroshima University School of Medicine, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
Mol Cell Biol 21:330-42. 2001..Therefore, these results suggest that Idax functions as a negative regulator of the Wnt signaling pathway by directly binding to the PDZ domain of Dvl...- Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosisK Morinaka
Department of Biochemistry, Hiroshima University School of Medicine, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
Oncogene 18:5915-22. 1999.... - Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3beta and beta-catenin and inhibits axis formation of Xenopus embryosH Yamamoto
Department of Biochemistry, Hiroshima University School of Medicine, Japan
Mol Cell Biol 18:2867-75. 1998..These results indicate that Axil negatively regulates the Wnt signaling pathway by mediating GSK-3beta-dependent phosphorylation of beta-catenin, thereby inhibiting axis formation... - Axin facilitates Smad3 activation in the transforming growth factor beta signaling pathwayM Furuhashi
Department of Biochemistry, The Japanese Foundation for Cancer Research JFCR Cancer Institute, Toshima ku, Tokyo 170 8455, Japan
Mol Cell Biol 21:5132-41. 2001..Axin may thus function as an adapter of Smad3, facilitating its activation by TGF-beta receptors for efficient TGF-beta signaling... - Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase IepsilonM Kishida
Department of Biochemistry, Faculty of Medicine, Hiroshima University, Kasumi, Minami-ku, Hiroshima 734-8551, Japan
J Biol Chem 276:33147-55. 2001..These results indicate that Dvl and CKIepsilon synergistically activated the Wnt signaling pathway and that the binding of the complex of Dvl and CKIepsilon to Axin is necessary for their synergistic action... - Inhibition of Wnt signaling pathway by a novel axin-binding proteinT Kadoya
Department of Biochemistry and Second Department of Surgery, Hiroshima University School of Medicine, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, PRESTO, Japan
J Biol Chem 275:37030-7. 2000..These results suggest that Axam regulates the Wnt signaling pathway negatively by inhibiting the binding of Dvl to Axin... - Regulation of complex formation of POB1/epsin/adaptor protein complex 2 by mitotic phosphorylationK Kariya
Department of Biochemistry, Hiroshima University School of Medicine, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
J Biol Chem 275:18399-406. 2000..These results suggest that phosphorylation of Epsin in mitotic phase inhibits receptor-mediated endocytosis by disassembly of its complex with POB1 and alpha-adaptin... - A novel beta-catenin-binding protein inhibits beta-catenin-dependent Tcf activation and axis formationI Sakamoto
Department of Biochemistry, Hiroshima University School of Medicine, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, PRESTO, Japan
J Biol Chem 275:32871-8. 2000..Thus, Duplin is a nuclear protein that inhibits beta-catenin signaling... - Inhibition of the Wnt signaling pathway by the PR61 subunit of protein phosphatase 2AH Yamamoto
Department of Biochemistry, Faculty of Medicine, Hiroshima University, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
J Biol Chem 276:26875-82. 2001..Taken together with the previous observations that PR61 interacts with APC and functions upstream of beta-catenin, these results demonstrate that PR61 regulates the Wnt signaling pathway at various steps... - GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with AxinS Ikeda
Department of Biochemistry, Hiroshima University School of Medicine, Japan
Oncogene 19:537-45. 2000..Taken together, these results suggest that GSK-3beta-dependent phosphorylation of APC can be modulated by beta-catenin and PP2A complexed with Axin... - Ras-interacting domain of Ral GDP dissociation stimulator like (RGL) reverses v-Ras-induced transformation and Raf-1 activation in NIH3T3 cellsM Okazaki
Department of Biochemistry, Hiroshima University School of Medicine, Japan
Cancer Res 56:2387-92. 1996.... - DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stabilityS Kishida
Department of Biochemistry, Hiroshima University School of Medicine, Minami Ku, Hiroshima 734 8551, Japan
Mol Cell Biol 19:4414-22. 1999..These results indicate that the DIX domains of Dvl-1 and Axin are important for protein-protein interactions and that they are necessary for the ability of Dvl-1 and Axin to regulate the stability of beta-catenin... - Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptorsS Nakashima
Department of Biochemistry, Hiroshima University School of Medicine, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
EMBO J 18:3629-42. 1999.... - Axin directly interacts with plakoglobin and regulates its stabilityS Kodama
Department of Biochemistry, Hiroshima University School of Medicine, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
J Biol Chem 274:27682-8. 1999..These results suggest that Axin regulates the stability of plakoglobin by enhancing its phosphorylation by GSK-3beta and that Axin may act on beta-catenin and plakoglobin in similar manners... - Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-cateninS Ikeda
Department of Biochemistry, Hiroshima University School of Medicine, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
EMBO J 17:1371-84. 1998..These results suggest that rAxin negatively regulates the Wnt signaling pathway by interacting with GSK-3beta and beta-catenin and mediating the signal from GSK-3beta to beta-catenin... - Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosisT Itoh
Department of Biochemistry, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
Science 291:1047-51. 2001..Thus, interaction between the ENTH domain and PtdIns(4,5)P2 is essential for endocytosis mediated by clathrin-coated pits... - Yeast glycogen synthase kinase 3 is involved in protein degradation in cooperation with Bul1, Bul2, and Rsp5T Andoh
Department of Biochemistry, Hiroshima University School of Medicine, Minami Ku, Hiroshima, Japan
Mol Cell Biol 20:6712-20. 2000..Furthermore, Rog1 is stabilized in the npi1 mutant, in which RSP5 expression levels are reduced. These results suggest that yeast GSK-3 regulates the stability of Rog1 in cooperation with Bul1, Bul2, and Rsp5... - Regulation of beta-catenin signaling in the Wnt pathwayA Kikuchi
Department of Biochemistry, Hiroshima University School of Medicine, 1 2 3, Kasumi, Minami Ku, Hiroshima, 734 8551, Japan
Biochem Biophys Res Commun 268:243-8. 2000..The amounts and functions of beta-catenin are regulated in both the cytoplasm and nucleus. Its molecular mechanisms are becoming increasingly well understood... 
AIP regulates stability of Aurora-A at early mitotic phase coordinately with GSK-3betaK Fumoto
Department of Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
Oncogene 27:4478-87. 2008..These results suggest that GSK-3beta modulates the early mitotic Aurora-A level through binding and phosphorylating AIP...- Tissue and subcellular distributions of the smg-21/rap1/Krev-1 proteins which are partly distinct from those of c-ras p21sS Kim
Department of Biochemistry, Kobe University School of Medicine, Japan
Mol Cell Biol 10:2645-52. 1990.... - Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of RalM Ikeda
Department of Biochemistry, Hiroshima University School of Medicine, 1 2 3 Kasumi, Minami Ku, Hiroshima 734, Japan
J Biol Chem 273:814-21. 1998..These results suggest that RalBP1 makes a complex with POB1 and that this complex may provide a link between tyrosine kinase, Src homology 3 (SH3)-containing protein, and Ral... - Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinaseH Yamamoto
Department of Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
Oncogene 29:2036-46. 2010..These results suggest that Wnt5a promotes the aggressiveness of prostate cancer and that its expression is involved in relapse after prostatectomy... - Purification, characterization, and possible functions of small molecular weight GTP-binding proteinsY Takai
Department of Biochemistry, Kobe University School of Medicine, Japan
Am J Hypertens 3:220S-223S. 1990..We conclude that small Mr G proteins and large Mr G proteins are components of large intracellular regulatory and messenger systems with specific roles in cell function regulation... - Crystallization and preliminary X-ray diffraction analysis of a rat biliverdin reductaseD Sun
Department of Biochemistry, Yamagata University School of Medicine, Yamagata 990 9585, Japan
Acta Crystallogr D Biol Crystallogr 56:1180-2. 2000..89, b = 70.41, c = 87.76 A. The complete determination of the crystallographic structure is currently in progress using MAD (multiwavelength anomalous diffraction) data from an Ir-derivative crystal... - Chondrocyte-derived ezrin-like domain containing protein (CDEP), a rho guanine nucleotide exchange factor, is inducible in chondrocytes by parathyroid hormone and cyclic AMP and has transforming activity in NIH3T3 cellsY Koyano
Department of Biochemistry, Hiroshima University School of Dentistry, Japan
Osteoarthritis Cartilage 9:S64-8. 2001..CONCLUSIONS: CDEP is a novel GEF for Rho family GTPases with the transforming activity. CDEP may play a role in mediating or modulating the action of cAMP-elevating hormones on maturing chondrocytes... - Characterization of the interaction of Raf-1 with ras p21 or 14-3-3 protein in intact cellsS Koyama
Department of Biochemistry, Hiroshima University School of Medicine, Japan
FEBS Lett 368:321-5. 1995..While Raf(1-135) did not interact with 14-3-3 protein, Raf(136-322) did. These results clearly indicate that Raf-1 simultaneously interacts with both ras p21 and 14-3-3 protein through the distinct binding domains in intact cells... - Profiling of genes expressed in human monocytes and monocyte-derived dendritic cells using cDNA expression arrayN Lapteva
Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Br J Haematol 114:191-7. 2001..Moreover, our data show the presence of a 'switch-on' step for the TNF-alpha and TNFRII gene expression in immature DCs for further differentiation into mature DCs... - NBP1 (Nap1 binding protein 1), an essential gene for G2/M transition of Saccharomyces cerevisiae, encodes a protein of distinct sub-nuclear localizationY Shimizu
Division of Gene Regulatorics, Institute for Enzyme Research, The University of Tokushima, Tokushima, Japan
Gene 246:395-404. 2000..This mutant also confers resistance against benomyl, a microtubule-destabilizing agent. Judging from the green fluorescent protein (GFP) signal fused with Nbp1p, this protein localizes in the nucleus as one or two tiny dots... - beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteinsW Chen
Department of Medicine, Howard Hughes Medical Institute, Duke University Medical Center, Box 3821, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 98:14889-94. 2001.... - Inhibitory effect of a presenilin 1 mutation on the Wnt signalling pathway by enhancement of beta-catenin phosphorylationY Kawamura
Department of Dementia Research, National Insititute for Longevity Sciences, Obu, Aichi, Japan
Eur J Biochem 268:3036-41. 2001..Thus, it appears that PS1 (M146L) mutation down-regulates the Wnt-3A-induced accumulation of beta-catenin due to an increase in the level of phosphorylated beta-catenin... - An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-cateninM Kitagawa
Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
EMBO J 18:2401-10. 1999..SCFFWD1 may be critical for tumor development and suppression through regulation of beta-catenin protein stability... - Hydrological setting of infertile species-rich wetland--a case study in the warm temperate JapanA Kikuchi
Graduate School for International Development and Cooperation, Hiroshima University, Higashi Hiroshima City, 739 8529 Japan
J Environ Sci (China) 15:279-83. 2003.... - Weekly carboplatin and paclitaxel is safe, active, and well tolerated in recurrent ovarian cancer cases of Japanese women previously treated with cisplatin-containing multidrug chemotherapyA Kikuchi
Department of Obstetrics and Gynecology, Nihon University School of Medicine, 30-1 Oyaguchi, Kamimachi, Itabashi, Tokyo 173-8610, Japan
Int J Gynecol Cancer 15:45-9. 2005..As second-line treatment of ovarian cancer should primarily provide high TI, WTJ regimen appears a better candidate, but its long-term survival benefit should be tested against MTJ... - Association of susceptibility to the development of pneumonia in the older Japanese population with haem oxygenase-1 gene promoter polymorphismH Yasuda
J Med Genet 43:e17. 2006..1 (95% confidence interval, 1.2 to 3.6). CONCLUSIONS: The large size of a (GT)n repeat in the HO-1 gene promoter may be associated with susceptibility to pneumonia in the older Japanese population... - Pns4 of rice dwarf virus is a phosphoprotein, is localized around the viroplasm matrix, and forms minitubulesT Wei
Laboratory of Virology, National Agricultural Research Center, Tsukuba, Ibaraki, Japan
Arch Virol 151:1701-12. 2006..Since viroplasms are believed to be the site of RDV replication, the intracellular location of Pns4 suggests that this protein might be involved in the process of assembly of the RDV virion... - Molecular cloning of the human cDNA for a stimulatory GDP/GTP exchange protein for c-Ki-ras p21 and smg p21A Kikuchi
Department of Biochemistry, Kobe University School of Medicine, Japan
Oncogene 7:289-93. 1992..The isolated cDNA is expressed in Escherichia coli, and the encoded protein shows the physical and functional properties similar to those of bovine smg GDS... - Identification and molecular cloning of yeast homolog of nucleosome assembly protein I which facilitates nucleosome assembly in vitroY Ishimi
Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
J Biol Chem 266:7025-9. 1991..Proteins recognized by the anti-NAP-I antibody were also present in Xenopus oocytes and Drosophila cultured cells. Possible roles of NAP-I are discussed in relation to other nucleosome assembly proteins... - Functional analysis of nucleosome assembly protein, NAP-1. The negatively charged COOH-terminal region is not necessary for the intrinsic assembly activityT Fujii-Nakata
Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
J Biol Chem 267:20980-6. 1992..This minimal size fragment could form the 12 S NAP-1-histone complex as the whole protein could, whereas deleted fragments on either side could bind with core histones only to form aggregates... - Inhibition of the ras p21 GTPase-activating protein-stimulated GTPase activity of c-Ha-ras p21 by smg p21 having the same putative effector domain as ras p21sY Hata
Department of Biochemistry, Kobe University School of Medicine, Japan
J Biol Chem 265:7104-7. 1990..c-Ha-ras p21 did not inhibit the smg p21 GAP1- or -2-stimulated GTPase activity of smg p21. These results indicate that ras p21 GAP interacts with smg p21 without the subsequent stimulation of its GTPase activity... - Molecular cloning of smg p21B and identification of smg p21 purified from bovine brain and human platelets as smg p21BY Matsui
Research Center, Mitsubishi Kasei Corporation, Yokohama, Japan
Biochem Biophys Res Commun 166:1010-6. 1990..Amino acid sequence analysis indicates that smg p21A is identical with the rap1A and Krev-1 proteins and smg p21B is identical with the rap1B protein... - The Drosophila Ral GTPase regulates developmental cell shape changes through the Jun NH(2)-terminal kinase pathwayK Sawamoto
Division of Neuroanatomy, Department of Neuroscience, Biomedical Research Center, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
J Cell Biol 146:361-72. 1999..These results indicate that DRal regulates developmental cell shape changes through the JNK pathway... - Solution structure of the Eps15 homology domain of a human POB1 (partner of RalBP1)S Koshiba
Cellular Signaling Laboratory, The Institute of Physical and Chemical Research RIKEN, Wako, Saitama, Japan
FEBS Lett 442:138-42. 1999.... 
Cell cycle-coupled relocation of types I and II topoisomerases and modulation of catalytic enzyme activitiesK N Meyer
Medizinische Poliklinik, University of Wurzburg, Germany
J Cell Biol 136:775-88. 1997..Scaffold-associated topoisomerase IIalpha appears not to be involved in catalytic DNA turnover, though it may play a role in the replicational cycle of centriols, where it accumulates during M phase...- Clinical significance of TAL1 gene alteration in childhood T-cell acute lymphoblastic leukemia and lymphomaA Kikuchi
Division of Hematology Oncology, Saitama Children s Medical Center, Japan
Leukemia 7:933-8. 1993..We conclude that tald rearrangement is restricted to T-cell ALL, for which it provides a useful clonal marker. Such patients with this rearrangement may constitute a subgroup of T-cell ALL with a good prognosis... - ralGDS family members interact with the effector loop of ras p21A Kikuchi
Cardiovascular Research Institute, University of California San Francisco 94143 0130
Mol Cell Biol 14:7483-91. 1994..Therefore, ralGDS family members may be effector proteins of ras p21 or may inhibit interactions between ras p21 and its effectors... - A new yeast gene, HTR1, required for growth at high temperature, is needed for recovery from mating pheromone-induced G1 arrestY Kikuchi
Department of Plant Sciences, Graduate School of Science, University of Tokyo, Japan
Mol Gen Genet 245:107-16. 1994..Thus the gene has at least two functions and is designated HTR1 (required for high temperature growth and recovery from G1 arrest induced by mating pheromone)... - Ectopic expression of constitutively activated Ral GTPase inhibits cell shape changes during Drosophila eye developmentK Sawamoto
Department of Neuroanatomy, Biomedical Research Center, Osaka University Medical School, Suita, Japan
Oncogene 18:1967-74. 1999..In addition, the phenotype was synergistically enhanced by the coexpression of RhoA. These results suggest that Ral functions to control the cytoskeletal structure required for cell shape changes during Drosophila development... - Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesisK Nagata
Department of Biomolecular Engineering, Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan
Proc Natl Acad Sci U S A 92:4279-83. 1995..Studies with mutant TAF-I proteins devoid of this acidic region indicated that the acidic region is essential for TAF-I activity... - Members of the NAP/SET family of proteins interact specifically with B-type cyclinsD R Kellogg
Department of Physiology, University of California, San Francisco 94143 0444, USA
J Cell Biol 130:661-73. 1995..This protein is the Xenopus homolog of the human SET protein, which was previously identified as part of a putative oncogenic fusion protein (Von Lindern et al., 1992)... - [Clinical courses and pathological findings in two gay male patients with acquired immunodeficiency syndrome infected in Japan]S Takamizawa
Second Department of Internal Medicine, Jikei University School of Medicine, Tokyo Japan
Kansenshogaku Zasshi 64:210-7. 1990..Furthermore, it is suggested that homosexual patients with AIDS may have unique opportunistic infections such as amebic dysentery or Giardia lamblia unlike other AIDS patients related to hemophilia... - ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cellsM Murata-Hori
Department of Biological Science, Faculty of Science, Hiroshima University, Higashi Hiroshima, Japan
FEBS Lett 451:81-4. 1999..Phosphorylation of myosin II by HeLa ZIPK resulted in activation of actin-activated MgATPase activity of myosin II. HeLa ZIPK is the first non-muscle MLCK that phosphorylates MRLC at two sites...