Research Topics
Species | T KamiyaSummaryAffiliation: Hiroshima University Country: Japan Publications
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Detail Information
Publications
Differential effects of amelogenin on mineralization of cementoblasts and periodontal ligament cellsKotaro Tanimoto
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, Minami Ku, Hiroshima, Japan
J Periodontol 83:672-9. 2012..The purpose of this study is to examine the effect of recombinant human full-length amelogenin (rh174) on the mineralization of human cementoblasts (HCEMs) and human periodontal ligament cells (HPDLs)...
Interleukin-1 beta affects cyclooxygenase-2 expression and cartilage metabolism in mandibular condyleKotaro Tanimoto
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
Arch Oral Biol 56:1412-8. 2011....
Superficial zone protein affects boundary lubrication on the surface of mandibular condylar cartilageKotaro Tanimoto
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, Minami Ku, Hiroshima, Japan
Cell Tissue Res 344:333-40. 2011..The removal of SZP from the surface layer of mandibular condylar cartilage by sPLA(2) resulted in a significant increase in the friction coefficient on the surface of articular cartilage...
Modulation of hyaluronan fragmentation by interleukin-1 beta in synovial membrane cellsK Tanimoto
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
Ann Biomed Eng 38:1618-25. 2010..However, HYAL activity was inhibited by transfection of HYAL2-siRNA. Our results suggest that IL-1beta is a crucial factor in the fragmentation of HA in inflammatory joints...
Modulation of hyaluronan catabolism in chondrocytes by mechanical stimuliKotaro Tanimoto
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University, Minami Ku, Hiroshima 734 8553, Japan
J Biomed Mater Res A 93:373-80. 2010..These results show that the expression of HYAL1 and HYAL2 in articular chondrocytes is enhanced by excessive mechanical stimuli and affected in part by induction of IL-1beta, leading to HA catabolism in articular cartilage...
Effects of mechanical stimuli on the synthesis of superficial zone protein in chondrocytesT Kamiya
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
J Biomed Mater Res A 92:801-5. 2010....
A case of anterior open bite with severely narrowed maxillary dental arch and hypertrophic palatine tonsilsKotaro Tanimoto
Orthodontics and Craniofacial Developmental Biology, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
J Orthod 35:5-15. 2008....
Inhibition of the proliferation of human periodontal ligament fibroblasts by hyaluronidaseKotaro Tanimoto
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
Arch Oral Biol 53:330-6. 2008..The CD44s mRNA level exhibited no significant changes. These results suggest that HA may contribute to modulate the proliferation of cultured human PDL cells through a CD44-mediated mechanism...
Proinflammatory cytokines regulate the gene expression of hyaluronic acid synthetase in cultured rabbit synovial membrane cellsK Tanimoto
Department of Orthodontics and Biochemistry, Hiroshima University, Faculty of Dentistry, Kasumi, Japan
Connect Tissue Res 42:187-95. 2001..These results suggest that proinflammatory cytokines regulate the HAS expression, and consequently may contribute to the accumulation and fragmentation of HA...
Effects of TGF-beta on hyaluronan anabolism in fibroblasts derived from the synovial membrane of the rabbit temporomandibular jointK Tanimoto
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
J Dent Res 83:40-4. 2004..These results suggest that TGF-beta 1 enhances the expression of HAS2 mRNA in the TMJ synovial membrane fibroblasts and may contribute to the production of high-molecular-weight HA in the joint fluid...
Hyaluronidase expression in cultured growth plate chondrocytes during differentiationKotaro Tanimoto
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8553, Japan
Cell Tissue Res 318:335-42. 2004..HAase activity was enhanced at the early matrix forming and hypertrophic stages. These results suggest that selective expression of HYALs is essential for extracellular HA metabolism during chondrocyte differentiation...
Expression and activity of Runx2 mediated by hyaluronan during chondrocyte differentiationY Tanne
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
Arch Oral Biol 53:478-87. 2008..These results suggest that HAoligo may affect the terminal differentiation of chondrocytes during the endochondral ossification by inhibiting the expression and activity of Runx2...
Applying an excessive mechanical stress alters the effect of subchondral osteoblasts on chondrocytes in a co-culture systemYu Yu Lin
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, Minami Ku, Hiroshima, Japan
Eur J Oral Sci 118:151-8. 2010..These results demonstrate that alterations in cartilage metabolism can be induced by stressed osteoblasts, indicating a possible explanation for the onset and progression of OA...
Expression of superficial zone protein in mandibular condyle cartilageS Ohno
Department of Orthodontics and Craniofacial Developmental Biology, Division of Cervico-Gnathostomatology, Hiroshima University Graduate School of Biomedical Sciences, Minami-ku, Hiroshima 734-8553, Japan
Osteoarthritis Cartilage 14:807-13. 2006....
The effect of mechanical loading on the metabolism of growth plate chondrocytesMasashi Ueki
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Hiroshima, 734 8553, Japan
Ann Biomed Eng 36:793-800. 2008..These may give more insight into the possible mechanism leading to endochondral bone formation...
Induction of CD44 and MMP expression by hyaluronidase treatment of articular chondrocytesMaiko Ohno-Nakahara
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553
J Biochem (Tokyo) 135:567-75. 2004..The results suggest that the fragmentation of HA may lead to cartilage destruction in terms of the enhanced expression of MMPs as well as the upregulation of CD44...
Activation of the hypoxia-inducible factor-1 in overloaded temporomandibular joint, and induction of osteoclastogenesisMaya Shirakura
Department of Orthodontics and Craniofacial Developmental Biology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
Biochem Biophys Res Commun 393:800-5. 2010..Inductions of Hif-1-target genes showed a similar expression pattern. In addition, expression of Opg decreased in hypoxia, and Hif-1alpha played a role, in part, in its regulation...
An adolescent patient with multiple impacted teethEiji Tanaka
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
Angle Orthod 78:1110-8. 2008..Since a delay in the treatment of impacted teeth may induce secondary problems such as root dilacerations and ankylosis, it is highly recommended to perform early treatment of multiple impacted teeth during adolescence...
Changes in urinary bone resorption markers (pyridinoline, deoxypyridinoline) resulting from experimentally-induced osteoarthritis in the temporomandibular joint of ratsMasae Imada
Dept of Orthodontics, Hiroshima University, Faculty of Dentistry, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
Cranio 21:38-45. 2003..These findings suggest that a urinary Pyr/Dpyr ratio would be available for the detection of degenerative changes in condyle relevant to temporomandibular joint osteoarthritis (TMJ OA)...
Immunohistochemical study of matrilin-1 in arthritic articular cartilage of the mandibular condyleShigeru Ohno
Department of Orthodontics, Faculty of Dentistry, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
J Oral Pathol Med 32:237-42. 2003..The objective of this study was to investigate the expression of matrilin-1 in arthritic articular cartilage of the mandibular condyle by means of immunohistochemical methods...
Lubrication of the temporomandibular jointEiji Tanaka
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8553, Japan
Ann Biomed Eng 36:14-29. 2008..Finally, in Part 4, the requirement and possibility of tissue engineering for treatment of TMDs with degenerative changes as a future treatment regimen will be discussed in a tribological context...
Ultrasound stimulation induces PGE(2) synthesis promoting cementoblastic differentiation through EP2/EP4 receptor pathwayEmanuel Braga Rego
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
Ultrasound Med Biol 36:907-15. 2010....
Mechanical regulation of terminal chondrocyte differentiation via RGD-CAP/beta ig-h3 induced by TGF-betaShigeru Ohno
Department of Orthodontics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
Connect Tissue Res 46:227-34. 2005..These results suggest that mechanical strain negatively regulates the terminal differentiation of chondrocytes through the signal pathway of TGF-ss with the induction of RGD-CAP...
Multidifferentiation potential of mesenchymal stem cells in three-dimensional collagen gel culturesKiyoshi Yoneno
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8553, Japan
J Biomed Mater Res A 75:733-41. 2005....
Effects of mechanical load on the expression and activity of hyaluronidase in cultured synovial membrane cellsReiko Kitamura
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8553, Japan
J Biomed Mater Res A 92:87-93. 2010..These results show that a cyclic tensile load induces the expression and activity of HYAL in synovial membrane cells, suggesting that increased HYAL by mechanical load affects HA catabolism in synovial fluid...
Effects of hyaluronan oligosaccharide on the expression of MMP-1 in periodontal ligament cellsYuki Nakatani
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
Arch Oral Biol 54:757-63. 2009..Neither inhibition of NFkB nor MAPKK activity affected the MMP-1 expression. It was suggested that HAoligo induces MMP-1 expression in HPDL cells, and p38MAPK plays a crucial role in signal transduction for MMP-1 inducted by HAoligo...
The mandibular cartilage metabolism is altered by damaged subchondral bone from traumatic impact loadingYu Yu Lin
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8553, Japan
Ann Biomed Eng 37:1358-67. 2009....
