Naosuke Kamei

Summary

Affiliation: Hiroshima University
Country: Japan

Publications

  1. ncbi request reprint Neural progenitor cells promote corticospinal axon growth in organotypic co-cultures
    Naosuke Kamei
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima City, Hiroshima734 8551, Japan
    Neuroreport 15:2579-83. 2004
  2. ncbi request reprint BDNF, NT-3, and NGF released from transplanted neural progenitor cells promote corticospinal axon growth in organotypic cocultures
    Naosuke Kamei
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima City, Hiroshima, Japan
    Spine (Phila Pa 1976) 32:1272-8. 2007
  3. doi request reprint Magnetic field-based delivery of human CD133⁺ cells promotes functional recovery after rat spinal cord injury
    Yuki Fujioka
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Spine (Phila Pa 1976) 37:E768-77. 2012
  4. doi request reprint Administration of human peripheral blood-derived CD133+ cells accelerates functional recovery in a rat spinal cord injury model
    Hirofumi Sasaki
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Spine (Phila Pa 1976) 34:249-54. 2009
  5. ncbi request reprint Magnetically labeled neural progenitor cells, which are localized by magnetic force, promote axon growth in organotypic cocultures
    Takahiko Hamasaki
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Spine (Phila Pa 1976) 32:2300-5. 2007
  6. ncbi request reprint Bone marrow stromal cells promoting corticospinal axon growth through the release of humoral factors in organotypic cocultures in neonatal rats
    Naosuke Kamei
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University Japan
    J Neurosurg Spine 6:412-9. 2007
  7. doi request reprint Acceleration of skeletal muscle regeneration in a rat skeletal muscle injury model by local injection of human peripheral blood-derived CD133-positive cells
    Ming Shi
    Department of Orthopedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Stem Cells 27:949-60. 2009
  8. doi request reprint The therapeutic potential of ex vivo expanded CD133+ cells derived from human peripheral blood for peripheral nerve injuries
    Shin Ohtsubo
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Neurosurg 117:787-94. 2012
  9. doi request reprint CD133+ cells from human peripheral blood promote corticospinal axon regeneration
    Risako Yamamoto
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Japan
    Neuroreport 19:799-803. 2008
  10. doi request reprint Regeneration of peripheral nerve after transplantation of CD133+ cells derived from human peripheral blood
    Yasumu Kijima
    Department of Orthopedic Surgery, Graduate School of Biomedical Sciences, Japan
    J Neurosurg 110:758-67. 2009

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Neural progenitor cells promote corticospinal axon growth in organotypic co-cultures
    Naosuke Kamei
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima City, Hiroshima734 8551, Japan
    Neuroreport 15:2579-83. 2004
    ..In addition, neural progenitor cell conditioned medium also significantly promoted axonal growth. These findings strongly suggest that factors derived from neural progenitor cells participate in the effect on axonal growth...
  2. ncbi request reprint BDNF, NT-3, and NGF released from transplanted neural progenitor cells promote corticospinal axon growth in organotypic cocultures
    Naosuke Kamei
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima City, Hiroshima, Japan
    Spine (Phila Pa 1976) 32:1272-8. 2007
    ..Experimental study of spinal cord injury using an organotypic slice culture...
  3. doi request reprint Magnetic field-based delivery of human CD133⁺ cells promotes functional recovery after rat spinal cord injury
    Yuki Fujioka
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Spine (Phila Pa 1976) 37:E768-77. 2012
    ..Experimental animal study of spinal cord injury (SCI), using a cell delivery system...
  4. doi request reprint Administration of human peripheral blood-derived CD133+ cells accelerates functional recovery in a rat spinal cord injury model
    Hirofumi Sasaki
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Spine (Phila Pa 1976) 34:249-54. 2009
    ..A rat model was used to investigate the hypothesis that the cell therapy using this clinically accessible cell fraction could be an attractive option for injured spinal cord...
  5. ncbi request reprint Magnetically labeled neural progenitor cells, which are localized by magnetic force, promote axon growth in organotypic cocultures
    Takahiko Hamasaki
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Spine (Phila Pa 1976) 32:2300-5. 2007
    ..An in vitro, rat animal study was conducted...
  6. ncbi request reprint Bone marrow stromal cells promoting corticospinal axon growth through the release of humoral factors in organotypic cocultures in neonatal rats
    Naosuke Kamei
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University Japan
    J Neurosurg Spine 6:412-9. 2007
    ....
  7. doi request reprint Acceleration of skeletal muscle regeneration in a rat skeletal muscle injury model by local injection of human peripheral blood-derived CD133-positive cells
    Ming Shi
    Department of Orthopedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Stem Cells 27:949-60. 2009
    ..These advantages could accelerate the progression of cell-based therapies for skeletal muscle injuries from laboratory to clinical implementation...
  8. doi request reprint The therapeutic potential of ex vivo expanded CD133+ cells derived from human peripheral blood for peripheral nerve injuries
    Shin Ohtsubo
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Neurosurg 117:787-94. 2012
    ..The purpose of this study was to determine the potential of ex vivo expanded CD133(+) cells to induce or enhance the repair of injured peripheral nerves...
  9. doi request reprint CD133+ cells from human peripheral blood promote corticospinal axon regeneration
    Risako Yamamoto
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Japan
    Neuroreport 19:799-803. 2008
    ..In contrast, the transplanted cells did not differentiate into endothelial cells. These data suggest that CD133 cells may promote axonal regeneration by upregulating vascular endothelial growth factor mRNA in spinal cord tissues...
  10. doi request reprint Regeneration of peripheral nerve after transplantation of CD133+ cells derived from human peripheral blood
    Yasumu Kijima
    Department of Orthopedic Surgery, Graduate School of Biomedical Sciences, Japan
    J Neurosurg 110:758-67. 2009
    ..In this study, the authors examined the use of blood-derived CD133(+) cells in promoting the repair of peripheral nerve defects...
  11. doi request reprint Clinical results of cervical myelopathy in patients older than 80 years of age: evaluation of spinal function with motor evoked potentials
    Nobuhiro Tanaka
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Neurosurg Spine 11:421-6. 2009
    ..In this prospective analysis the authors describe the clinical results of surgical treatment in patients > 80 years of age in whom spinal function was evaluated with motor evoked potential (MEPs) monitoring...
  12. pmc Quantitative assessment of myelopathy patients using motor evoked potentials produced by transcranial magnetic stimulation
    Toshio Nakamae
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, Hiroshima, 734 8551, Japan
    Eur Spine J 19:685-90. 2010
    ..MEP abnormalities are useful for an electrophysiological evaluation of myelopathy patients. Moreover, MEPs may be effective parameters in spinal pathology for deciding the operative treatment...
  13. ncbi request reprint Significant correlation between corticospinal tract conduction block and prolongation of central motor conduction time in compressive cervical myelopathy
    Kazuyoshi Nakanishi
    Department of Orthopaedic Surgery, Programs for Applied Biomedicine, Division of Clinical Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1 2 3, Hiroshima, Japan
    J Neurol Sci 256:71-4. 2007
    ..Spinal motor neurons might need more time to fire in patients with compressive cervical myelopathy when corticospinal potentials, but not conduction, are attenuated, thereby resulting in prolonged CMCT...
  14. doi request reprint Expansive laminoplasty for cervical myelopathy with interconnected porous calcium hydroxyapatite ceramic spacers: comparison with autogenous bone spacers
    Nobuhiro Tanaka
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Spinal Disord Tech 21:547-52. 2008
    ..Expansive cervical laminoplasties with interconnected porous calcium hydroxyapatite ceramic (IP-CHA) spacers were performed in cervical myelopathy patients...
  15. doi request reprint CD133+ cells from human umbilical cord blood reduce cortical damage and promote axonal growth in neonatal rat organ co-cultures exposed to hypoxia
    Norifumi Tanaka
    Department of Obstetrics and Gynecology, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima City, Hiroshima, 734 8551, Japan
    Int J Dev Neurosci 28:581-7. 2010
    ..These results suggest that CD133(+) cell transplantation may be a possible therapeutic intervention for perinatal hypoxia-induced brain injury...
  16. pmc Magnetic targeting of human peripheral blood CD133+ cells for skeletal muscle regeneration
    Shingo Ohkawa
    Programs for Applied Biomedicine, Division of Clinical Medical Science, Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Tissue Eng Part C Methods 19:631-41. 2013
    ..Thus, our magnetic cell targeting system enables transplantation of a limited number of CD133(+) cells to promote the repair of skeletal muscle injury. ..
  17. doi request reprint Assessment of central motor conduction time in the diagnosis of compressive thoracic myelopathy
    Kazuyoshi Nakanishi
    Department of Orthopedic Surgery, Programs for Applied Biomedicine, Division of Clinical Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Spine (Phila Pa 1976) 35:E1593-8. 2010
    ..Prospective clinical study...
  18. doi request reprint Investigation of segmental motor paralysis after cervical laminoplasty using intraoperative spinal cord monitoring with transcranial electric motor-evoked potentials
    Toshio Nakamae
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Spinal Disord Tech 25:92-8. 2012
    ..A retrospective study of segmental motor paralysis after cervical laminoplasty for cervical myelopathy...
  19. doi request reprint The effects of combining chondroitinase ABC and NEP1-40 on the corticospinal axon growth in organotypic co-cultures
    Toshio Nakamae
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Neurosci Lett 476:14-7. 2010
    ..There is a possibility that ChABC and NEP1-40 affect the same intracellular pathways and have no synergistic influence on axonal growth...
  20. doi request reprint Long-term clinical results of microsurgical transdural discectomy with laminoplasty: follow-up results over 10 years
    Nobuhiro Tanaka
    Department of Orthopaedic Surgery, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
    J Neurosurg Spine 18:653-60. 2013
    ..In this retrospective analysis the authors describe the long-term clinical results of microsurgical transdural discectomy with laminoplasty (MTDL) in patients with cervical disc herniation (CDH)...
  21. pmc Heme oxygenase-1 modulates degeneration of the intervertebral disc after puncture in Bach 1 deficient mice
    Ryo Ohta
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi, Hiroshima, 734 8551, Japan
    Eur Spine J 21:1748-57. 2012
    ..HO-1 protects cells from oxidative stress...
  22. ncbi request reprint Magnetic targeting of bone marrow stromal cells into spinal cord: through cerebrospinal fluid
    Koji Nishida
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Neuroreport 17:1269-72. 2006
    ..This targeting system may be a useful tool in minimally invasive transplantation of bone marrow stromal cells for the treatment of spinal cord injury...
  23. ncbi request reprint Characterization of labeled neural progenitor cells for magnetic targeting
    Takahiko Hamasaki
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Japan
    Neuroreport 16:1641-5. 2005
    ..Labeled neural progenitor cells have the potential to be used in magnetic targeting systems in-vivo models...
  24. doi request reprint Medium-term clinical results of microsurgical lumbar flavectomy that preserves facet joints in cases of lumbar degenerative spondylolisthesis: comparison of bilateral laminotomy with bilateral decompression by a unilateral approach
    Kazuyoshi Nakanishi
    Department of Orthopaedic Surgery, Programs for Applied Biomedicine, Division of Clinical Medical Science, Graduate School of Biomedical Sciences, Hiroshima University Department of Orthopaedic Surgery, Hiroshima General Hospital, Hiroshima, Japan
    J Spinal Disord Tech 26:351-8. 2013
    ..A retrospective study of medium-term results...
  25. doi request reprint Surgical treatment of high-grade dysplastic spondylolisthesis using intraoperative electrophysiological monitoring: report of two cases and review of the literature
    Toshio Nakamae
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima City, Hiroshima, 734 8551, Japan
    Eur J Orthop Surg Traumatol 23:S121-7. 2013
    ..We successfully perform the surgery without any neurological deficit using intraoperative electrophysiological monitoring...
  26. doi request reprint Modulation of the secondary injury process after spinal cord injury in Bach1-deficient mice by heme oxygenase-1
    Kiyotaka Yamada
    Department of Orthopaedic Surgery, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan
    J Neurosurg Spine 9:611-20. 2008
    ..The authors hypothesized that HO-1 modulates the secondary injury process after SCI in Bach1(-/-) mice...
  27. doi request reprint Human platelet-rich plasma promotes axon growth in brain-spinal cord coculture
    Michiko Takeuchi
    Department of Orthopaedic Surgery, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan
    Neuroreport 23:712-6. 2012
    ..These findings indicate that PRP promotes axon growth in spinal cord tissues through mechanisms associated with IGF-1 and VEGF, and that TGF-β1 in PRP exerts negative effects on axon growth...
  28. ncbi request reprint Surgical outcome of posterior decompression for cervical spondylosis with unilateral upper extremity amyotrophy
    Yasushi Fujiwara
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Spine (Phila Pa 1976) 31:E728-32. 2006
    ..Case studies of patients with cervical spondylosis with unilateral upper extremity amyotrophy...
  29. doi request reprint MicroRNA-223 expression in neutrophils in the early phase of secondary damage after spinal cord injury
    Bunichiro Izumi
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Neurosci Lett 492:114-8. 2011
    ..Double staining of in situ hybridization and immunohistochemistry showed that the signals of miR-223 merged with Gr-1 positive neutrophils. Our data indicate that miR-223 might regulate neutrophils in the early phase after SCI...
  30. ncbi request reprint Postoperative segmental C5 palsy after cervical laminoplasty may occur without intraoperative nerve injury: a prospective study with transcranial electric motor-evoked potentials
    Nobuhiro Tanaka
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Spine (Phila Pa 1976) 31:3013-7. 2006
    ..Intraoperative neurophysiologic monitoring with transcranial electric motor-evoked potentials was performed on patients who underwent cervical laminoplasty at a university hospital in a prospective study...
  31. doi request reprint The effect of intra-articular injection of microRNA-210 on ligament healing in a rat model
    Takeshi Shoji
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Japan
    Am J Sports Med 40:2470-8. 2012
    ....
  32. doi request reprint In vivo bioluminescence imaging of magnetically targeted bone marrow-derived mesenchymal stem cells in skeletal muscle injury model
    Akihiro Nakabayashi
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minaki ku, Hiroshima 734 8551, Japan
    J Orthop Res 31:754-9. 2013
    ..The results of our study indicated that magnetic cell delivery system may be of use in directing the transplanted MSCs to the injury site to promote skeletal muscle regeneration...
  33. doi request reprint Use of prone position magnetic resonance imaging for detecting the terminal filum in patients with occult tethered cord syndrome
    Kazuyoshi Nakanishi
    Department of Orthopaedic Surgery, Programs for Applied Biomedicine, Division of Clinical Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Neurosurg Spine 18:76-84. 2013
    ..The authors hypothesized that the posterior displacement of the terminal filum may become prominent in patients with OCTS who are in a prone position if filum inelasticity exists, and they investigated prone-position MRI findings...
  34. ncbi request reprint Corticospinal tract conduction block results in the prolongation of central motor conduction time in compressive cervical myelopathy
    Kazuyoshi Nakanishi
    Programs for Applied Biomedicine, Division of Clinical Medical Science, Department of Orthopedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Minami Ku, Hiroshima 734 8551, Japan
    Clin Neurophysiol 117:623-7. 2006
    ..The objective of this study was to analyze corticospinal function in patients with compressive cervical myelopathy and to elucidate the mechanism underlying its prolonged central motor conduction time (CMCT)...
  35. pmc Treatment of cartilage defects by subchondral drilling combined with covering with atelocollagen membrane induces osteogenesis in a rat model
    Michio Hamanishi
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Orthop Sci 18:627-35. 2013
    ....
  36. doi request reprint Contribution of bone marrow-derived endothelial progenitor cells to neovascularization and astrogliosis following spinal cord injury
    Naosuke Kamei
    Group of Vascular Regeneration Research, Institute of Biomedical Research and Innovation, Kobe, Hyogo, Japan
    J Neurosci Res 90:2281-92. 2012
    ..These findings suggest that bone marrow-derived EPCs may contribute to the tissue repair by augmenting neovascularization and astrogliosis following spinal cord injury...
  37. ncbi request reprint Intradural extramedullary mass formation in spinal cord sarcoidosis: case report and literature review
    Takahiko Hamasaki
    Department of Orthopaedic Surgery, Matsuyama Red Cross Hospital, Ehime, Japan
    Spine (Phila Pa 1976) 28:E420-3. 2003
    ..A case of myelopathy caused by intradural extramedullary spinal cord sarcoidosis...