Yasuhiro Ishihara

Summary

Affiliation: Hiroshima University
Country: Japan

Publications

  1. doi request reprint Dual role of superoxide dismutase 2 induced in activated microglia: oxidative stress tolerance and convergence of inflammatory responses
    Yasuhiro Ishihara
    From the Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi hiroshima 739 8521, Japan and
    J Biol Chem 290:22805-17. 2015
  2. doi request reprint Selective estrogen-receptor modulators suppress microglial activation and neuronal cell death via an estrogen receptor-dependent pathway
    Yasuhiro Ishihara
    Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi hiroshima 739 8521, Japan Electronic address
    J Steroid Biochem Mol Biol 145:85-93. 2015
  3. doi request reprint Suppressive effects of 17β-estradiol on tributyltin-induced neuronal injury via Akt activation and subsequent attenuation of oxidative stress
    Yasuhiro Ishihara
    Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi hiroshima 739 8521, Japan Electronic address
    Life Sci 99:24-30. 2014
  4. ncbi request reprint Enhancement of quinone hepatotoxicity by cytochrome P450 inhibition
    Yasuhiro Ishihara
    Graduate School of Integrated Arts and Sciences, Hiroshima University, 1 7 1 Kagamiyama, Higashi Hiroshima, Hiroshima 739 8521, Japan
    Yakugaku Zasshi 133:873-8. 2013
  5. doi request reprint Involvement of brain oxidation in the cognitive impairment in a triple transgenic mouse model of Alzheimer's disease: noninvasive measurement of the brain redox state by magnetic resonance imaging
    Y Ishihara
    Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi Hiroshima, Japan
    Free Radic Res 47:731-9. 2013
  6. ncbi request reprint Contribution of reductase activity to quinone toxicity in three kinds of hepatic cells
    Yasuhiro Ishihara
    Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi Hiroshima, Japan
    Biol Pharm Bull 35:634-8. 2012
  7. doi request reprint Tributyltin induces oxidative stress and neuronal injury by inhibiting glutathione S-transferase in rat organotypic hippocampal slice cultures
    Yasuhiro Ishihara
    Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi Hiroshima, Japan
    Neurochem Int 60:782-90. 2012
  8. doi request reprint Accumulation of cytochrome P450 induced by proteasome inhibition during cardiac ischemia
    Yasuhiro Ishihara
    Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi hiroshima 739 8521, Japan
    Arch Biochem Biophys 527:16-22. 2012
  9. ncbi request reprint Sulfaphenazole attenuates myocardial cell apoptosis accompanied with cardiac ischemia-reperfusion by suppressing the expression of BimEL and Noxa
    Yasuhiro Ishihara
    Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi Hiroshima, Hiroshima 739 8521, Japan
    J Pharmacol Sci 119:251-9. 2012
  10. doi request reprint Allopregnanolone-mediated protective effects of progesterone on tributyltin-induced neuronal injury in rat hippocampal slices
    Yasuhiro Ishihara
    Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi hiroshima 739 8521, Japan
    J Steroid Biochem Mol Biol 135:1-6. 2013

Detail Information

Publications15

  1. doi request reprint Dual role of superoxide dismutase 2 induced in activated microglia: oxidative stress tolerance and convergence of inflammatory responses
    Yasuhiro Ishihara
    From the Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi hiroshima 739 8521, Japan and
    J Biol Chem 290:22805-17. 2015
    ..Therefore, SOD2 might regulate neuroinflammation by controlling the microglial activities. ..
  2. doi request reprint Selective estrogen-receptor modulators suppress microglial activation and neuronal cell death via an estrogen receptor-dependent pathway
    Yasuhiro Ishihara
    Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi hiroshima 739 8521, Japan Electronic address
    J Steroid Biochem Mol Biol 145:85-93. 2015
    ..SERMs could represent a novel therapeutic strategy for disorders of the central nervous system based on their ability to suppress neuroinflammation. ..
  3. doi request reprint Suppressive effects of 17β-estradiol on tributyltin-induced neuronal injury via Akt activation and subsequent attenuation of oxidative stress
    Yasuhiro Ishihara
    Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi hiroshima 739 8521, Japan Electronic address
    Life Sci 99:24-30. 2014
    ..In this study, we examined the suppressive effects of 17β-estradiol (E2) on tributyltin (TBT)-induced neurotoxicity...
  4. ncbi request reprint Enhancement of quinone hepatotoxicity by cytochrome P450 inhibition
    Yasuhiro Ishihara
    Graduate School of Integrated Arts and Sciences, Hiroshima University, 1 7 1 Kagamiyama, Higashi Hiroshima, Hiroshima 739 8521, Japan
    Yakugaku Zasshi 133:873-8. 2013
    ..Here, we revisit the generally accepted mechanisms of quinone hepatotoxicity and propose the importance of cytochrome P450 systems in quinone-induced hepatotoxicity on the basis of our recent work...
  5. doi request reprint Involvement of brain oxidation in the cognitive impairment in a triple transgenic mouse model of Alzheimer's disease: noninvasive measurement of the brain redox state by magnetic resonance imaging
    Y Ishihara
    Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi Hiroshima, Japan
    Free Radic Res 47:731-9. 2013
    ..Furthermore, MRI might be a powerful tool to noninvasively evaluate the increases in reactive radicals, especially those occurring during the early stages of AD...
  6. ncbi request reprint Contribution of reductase activity to quinone toxicity in three kinds of hepatic cells
    Yasuhiro Ishihara
    Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi Hiroshima, Japan
    Biol Pharm Bull 35:634-8. 2012
    ..These data suggest that cells with a high reductase activity are susceptible to redox cycling quinones. This study provides essential evidence to assess the toxicity of quinone-based drugs during their developmental processes...
  7. doi request reprint Tributyltin induces oxidative stress and neuronal injury by inhibiting glutathione S-transferase in rat organotypic hippocampal slice cultures
    Yasuhiro Ishihara
    Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi Hiroshima, Japan
    Neurochem Int 60:782-90. 2012
    ..This study is the first report to show the link between neuronal oxidative injury and the GST inhibition elicited by TBT...
  8. doi request reprint Accumulation of cytochrome P450 induced by proteasome inhibition during cardiac ischemia
    Yasuhiro Ishihara
    Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi hiroshima 739 8521, Japan
    Arch Biochem Biophys 527:16-22. 2012
    ..Accumulated CYPs might be involved in myocardial infarction and dysfunction during reperfusion...
  9. ncbi request reprint Sulfaphenazole attenuates myocardial cell apoptosis accompanied with cardiac ischemia-reperfusion by suppressing the expression of BimEL and Noxa
    Yasuhiro Ishihara
    Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi Hiroshima, Hiroshima 739 8521, Japan
    J Pharmacol Sci 119:251-9. 2012
    ..Taken together, treatment with SPZ could attenuate the myocardial cell apoptosis accompanied with I/R by inhibiting the mitochondrial dysfunction due to decreases in the expression of BimEL and Noxa...
  10. doi request reprint Allopregnanolone-mediated protective effects of progesterone on tributyltin-induced neuronal injury in rat hippocampal slices
    Yasuhiro Ishihara
    Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi hiroshima 739 8521, Japan
    J Steroid Biochem Mol Biol 135:1-6. 2013
    ..One of the physiological roles of neuroactive steroids might be neuroprotection from environmental chemicals...
  11. pmc De novo synthesized estradiol protects against methylmercury-induced neurotoxicity in cultured rat hippocampal slices
    Takeshi Yamazaki
    Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi Hiroshima, Japan
    PLoS ONE 8:e55559. 2013
    ..In this study, the protective effect of de novo synthesized 17β-estradiol on MeHg-induced neurotoxicity in rat hippocampus was examined...
  12. doi request reprint Protective actions of 17β-estradiol and progesterone on oxidative neuronal injury induced by organometallic compounds
    Yasuhiro Ishihara
    Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashihiroshima 739 8521, Japan
    Oxid Med Cell Longev 2015:343706. 2015
    ....
  13. doi request reprint Neuroprotection elicited by nerve growth factor and brain-derived neurotrophic factor released from astrocytes in response to methylmercury
    Takuya Takemoto
    Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi hiroshima 739 8521, Japan
    Environ Toxicol Pharmacol 40:199-205. 2015
    ..Taken together, astrocytes synthesize and release NGF and BDNF in response to MeHg to protect neurons from MeHg toxicity. This study is considered to show a novel defense mechanism against MeHg-induced neurotoxicity...
  14. doi request reprint Antioxidant properties of rare sugar D-allose: Effects on mitochondrial reactive oxygen species production in Neuro2A cells
    Yasuhiro Ishihara
    Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi hiroshima 739 8521, Japan
    J Biosci Bioeng 112:638-42. 2011
    ..Treatment with D-allose inhibited the ATP synthesis stimulated by D-glucose. These results suggest that D-allose suppresses ROS production in the mitochondria due to competition with D-glucose at the cellular level...
  15. pmc An active C-terminally truncated form of Ca (2+) /calmodulin-dependent protein kinase phosphatase-N (CaMKP-N/PPM1E)
    Atsuhiko Ishida
    Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi hiroshima 739 8521, Japan
    Biomed Res Int 2013:134813. 2013
    ..The truncated CaMKP-N may play an important physiological role in neuronal cells...