Research Topics
Species | H HondaSummaryAffiliation: Hiroshima University Country: Japan Publications
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Detail Information
Publications
Successful diagnosis of fetal gender using conventional PCR analysis of maternal serumH Honda
Department of Obstetrics and Gynecology, Hiroshima University School of Medicine, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
Clin Chem 47:41-6. 2001..Fetal DNA has been found in maternal plasma and serum. Diagnosis of fetal gender using maternal plasma and serum has been attempted in an effort to develop a new noninvasive method of prenatal diagnosis...- Fetal gender determination in early pregnancy through qualitative and quantitative analysis of fetal DNA in maternal serumHiroshi Honda
Department of Obstetrics and Gynecology, Hiroshima University School of Medicine, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
Hum Genet 110:75-9. 2002..Thus, we could confidently determine fetal gender by using maternal serum samples taken as early as the 7th week... - Analysis of segregation and aneuploidy in two reciprocal translocation carriers, t(3;9)(q26.2;q32) and t(3;9)(p25;q32), by triple-color fluorescence in situ hybridizationH Honda
Department of Obstetrics and Gynecology, Hiroshima University School of Medicine, Japan
Hum Genet 105:428-36. 1999..Additional dual-color and triple-color FISH were performed to analyze aneuploidy rates for chromosomes 12, 17, 18, X and Y in order to detect any interchromosomal effect; no evidence of an interchromosomal effect was found... - Quantitation of fetal DNA in maternal serum in normal and aneuploid prenanciesY Ohashi
Department of Obstetrics and Gynecology, Hiroshima, Japan
Hum Genet 108:123-7. 2001..5 copies/ml in the pregnancies with 46,XY,+18. There were no significant differences in the concentration of fetal DNA between pregnancies with fetuses of normal karyotype and those with fetuses of abnormal karyotype... - High frequency of XY disomy in spermatozoa of severe oligozoospermic menY Ohashi
Department of Obstetrics and Gynecology, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
Hum Reprod 16:703-8. 2001..18%, P < 0.05; 0.21%, P < 0.05) (Mann-Whitney U-test). The data suggest that when severe oligozoospermic men undergo intracytoplasmic sperm injection, there can be an increase in the rate of conceptuses with 47,XXY chromosomes... - Effects of environmental estrogenic compounds on growth of a transplanted estrogen responsive pituitary tumor cell line in ratsN Fujimoto
Department of Developmental Biology, RIRBM, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
Food Chem Toxicol 41:1711-7. 2003..These results indicate that Gen might facilitate the estrogen responsive tumor development if only the promotion phase is concerned, while NP and Atz at doses used in the present study were without effect... 
Identification of Zfp521/ZNF521 as a cooperative gene for E2A-HLF to develop acute B-lineage leukemiaN Yamasaki
Department of Developmental Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Minami Ku, Hiroshima, Japan
Oncogene 29:1963-75. 2010....
Of the GATA-binding proteins, only GATA-4 selectively regulates the human interleukin-5 gene promoter in interleukin-5-producing cells which express multiple GATA-binding proteinsT Yamagata
Third Department of Internal Medicine, Tokyo University, Japan
Mol Cell Biol 15:3830-9. 1995..These results demonstrate the selective role of GATA-4 in the transcriptional regulation of the IL-5 gene in a circumstance where multiple members of the GATA-binding proteins are expressed...- Effects of phytoestrogens on acetylcholine- and isoprenaline-induced vasodilation in rat aortaK Yamaguchi
Department of Pharmacology, Tokyo University of Pharmacy and Life Science, Hachioji, Japan
Jpn J Pharmacol 87:67-73. 2001..These results indicate that phytoestrogen, isoflavones, certainly possess estrogenic actions on the vasodilating responses caused by ACh and ISO, as well as a weaker uterotrophic effect... - ICSAT overexpression is not sufficient to cause adult T-cell leukemia or multiple myelomaT Saito
Department of Hematology and Oncology, Graduate School of Medicine, Universiy of Tokyo, Tokyo, 113 8655, Japan
Biochem Biophys Res Commun 260:329-31. 1999..ICSAT overexpression in lymphocytes seems insufficient for the leukemogenesis of ATL or multiple myeloma (MM), however, it may regulate T cell activation and its overexpression may lead to leukemogenesis via controlling IL-2 production... - Cloning and characterization of mouse tec promoterH Honda
Department of Molecular Biology, Institute of Hematology, Jichi Medical School, Tochigi ken, Japan
Biochem Biophys Res Commun 223:422-6. 1996..The promoter activity of the 5' flanking region was confirmed by using the luciferase assay. The present analysis will provide insights into the mechanism for the expression and regulation of the Tec molecule... - Augmentation of MHC class I antigen presentation via heat shock protein expression by hyperthermiaA Ito
Department of Biotechnology, Graduate School of Engineering, Nagoya University, Japan
Cancer Immunol Immunother 50:515-22. 2001..These results may benefit further efforts on developing novel cancer immunotherapies based on hyperthermia... - Heat-inducible TNF-alpha gene therapy combined with hyperthermia using magnetic nanoparticles as a novel tumor-targeted therapyA Ito
Department of Biotechnology, Graduate School of Engineering, Nagoya University, Nagoya 464-8603, Japan
Cancer Gene Ther 8:649-54. 2001..The combined treatment strongly arrested tumor growth in nude mice over a 30-day period, suggesting potential for cancer treatment... - Possible horizontal transfer of a transposable element from host to parasitoidM Yoshiyama
Laboratory of Applied Zoology, Institute of Agriculture and Forestry, University of Tsukuba, Tsukuba, Ibaraki, Japan
Mol Biol Evol 18:1952-8. 2001..honmai were 97.6% identical in DNA sequence. This high similarity suggests a recent horizontal transfer, probably from the moth host to the wasp parasitoid, facilitated by the intimacy of the host-parasitoid relationship... - Hepatic stellate cells contain the functional estrogen receptor beta but not the estrogen receptor alpha in male and female ratsY Zhou
Second Department of Internal Medicine, Tokushima University School of Medicine, Kuramoto-cho, Tokushima, 770-8503, Japan
Biochem Biophys Res Commun 286:1059-65. 2001..These findings demonstrate for the first time that rat HSCs possess functional Erbeta, but not Eralpha, to respond directly to E2 exposure... - Identification of PU.1 and Sp1 as essential transcriptional factors for the promoter activity of mouse tec geneH Honda
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo ku, Japan
Biochem Biophys Res Commun 234:376-81. 1997..1 and Sp1 are essential for the transcriptional activity of the tec promoter and suggest that the cooperation of PU.1 and Sp1 plays a substantial role in the preferential expression of the Tec molecule in the hematopoietic lineages... - Development of acute lymphoblastic leukemia and myeloproliferative disorder in transgenic mice expressing p210bcr/abl: a novel transgenic model for human Ph1-positive leukemiasH Honda
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
Blood 91:2067-75. 1998.... - Retardation of skeletal development and cervical abnormalities in transgenic mice expressing a dominant-negative retinoic acid receptor in chondrogenic cellsM Yamaguchi
Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
Proc Natl Acad Sci U S A 95:7491-6. 1998..Great similarities of the phenotypes between our mice and reported RAR knockout mice revealed that chondrogenic cells are a principal RA target during complex cascades of skeletal development... - Nonredundant roles of the elongation factor MEN in postimplantation developmentK Mitani
Department of Hematology and Oncology, Graduate School of Medicine, Tokyo, Japan
Biochem Biophys Res Commun 279:563-7. 2000..5 embryos, which were gradually resorbed by E8.5. Our findings demonstrated that MEN-/- mice are embryonic lethal, and die before E6.5 and after implantation. MEN should play a nonredundant role in postimplantation development of mice... - Up-regulation of natriuretic peptides in the ventricle of Csx/Nkx2-5 transgenic miceE Takimoto
Department of Cardiovascular Medicine, Department of Hematology and Oncology, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
Biochem Biophys Res Commun 270:1074-9. 2000..These results suggest that Csx/Nkx2-5 regulates many cardiac genes and induces formation of secretory granules in the adult ventricle... - Expression of E2A-HLF chimeric protein induced T-cell apoptosis, B-cell maturation arrest, and development of acute lymphoblastic leukemiaH Honda
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
Blood 93:2780-90. 1999..Our findings provide insight into the biological function of E2A-HLF in lymphoid development and also its role in leukemogenesis... - Spontaneously immortalized adult mouse Schwann cells secrete autocrine and paracrine growth-promoting activitiesK Watabe
Division of Neuropathology, Jikei University School of Medicine, Tokyo, Japan
J Neurosci Res 41:279-90. 1995..These results indicate that the immortalized Schwann cell line mitotically responds to various growth factors and secretes autocrine and paracrine growth-promoting activities in vitro...