Y Higashi

Summary

Affiliation: Hiroshima University
Country: Japan

Publications

  1. ncbi request reprint Nocturnal decline in blood pressure is attenuated by NaCl loading in salt-sensitive patients with essential hypertension: noninvasive 24-hour ambulatory blood pressure monitoring
    Y Higashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, Minami Ku, Japan
    Hypertension 30:163-7. 1997
  2. ncbi request reprint Effect of the angiotensin-converting enzyme inhibitor imidapril on reactive hyperemia in patients with essential hypertension: relationship between treatment periods and resistance artery endothelial function
    Y Higashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    J Am Coll Cardiol 37:863-70. 2001
  3. ncbi request reprint Effect of estrogen replacement therapy on endothelial function in peripheral resistance arteries in normotensive and hypertensive postmenopausal women
    Y Higashi
    First Department of Internal Medicine, Division of Physical Therapy, Institute of Health Sciences, Hiroshima University School of Medicine, Hiroshima, Japan
    Hypertension 37:651-7. 2001
  4. ncbi request reprint A noninvasive measurement of reactive hyperemia that can be used to assess resistance artery endothelial function in humans
    Y Higashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    Am J Cardiol 87:121-5, A9. 2001
  5. ncbi request reprint A comparison of angiotensin-converting enzyme inhibitors, calcium antagonists, beta-blockers and diuretic agents on reactive hyperemia in patients with essential hypertension: a multicenter study
    Y Higashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    J Am Coll Cardiol 35:284-91. 2000
  6. ncbi request reprint Regular aerobic exercise augments endothelium-dependent vascular relaxation in normotensive as well as hypertensive subjects: role of endothelium-derived nitric oxide
    Y Higashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    Circulation 100:1194-202. 1999
  7. ncbi request reprint Effect of L-arginine infusion on systemic and renal hemodynamics in hypertensive patients
    Y Higashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    Am J Hypertens 12:8-15. 1999
  8. ncbi request reprint Aging and severity of hypertension attenuate endothelium-dependent renal vascular relaxation in humans
    Y Higashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, Minami Ku, Japan
    Hypertension 30:252-8. 1997
  9. ncbi request reprint Daily aerobic exercise improves reactive hyperemia in patients with essential hypertension
    Y Higashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    Hypertension 33:591-7. 1999
  10. ncbi request reprint Angiotensin-converting enzyme inhibition, but not calcium antagonism, improves a response of the renal vasculature to L-arginine in patients with essential hypertension
    Y Higashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    Hypertension 32:16-24. 1998

Detail Information

Publications22

  1. ncbi request reprint Nocturnal decline in blood pressure is attenuated by NaCl loading in salt-sensitive patients with essential hypertension: noninvasive 24-hour ambulatory blood pressure monitoring
    Y Higashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, Minami Ku, Japan
    Hypertension 30:163-7. 1997
    ..57 versus 0.26, chi2=6.4; P=.02; odds ratio, 3.82). These findings suggest that the NaCl loading blunted the nocturnal decline in blood pressure in salt-sensitive patients but not in salt-resistant patients...
  2. ncbi request reprint Effect of the angiotensin-converting enzyme inhibitor imidapril on reactive hyperemia in patients with essential hypertension: relationship between treatment periods and resistance artery endothelial function
    Y Higashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    J Am Coll Cardiol 37:863-70. 2001
    ..The purpose of this study was to evaluate the effects of the angiotensin-converting enzyme (ACE) inhibitor imidapril and the calcium antagonist amlodipine on endothelial function before and after 2, 4, 8, 12, 24 and 48 weeks of treatment...
  3. ncbi request reprint Effect of estrogen replacement therapy on endothelial function in peripheral resistance arteries in normotensive and hypertensive postmenopausal women
    Y Higashi
    First Department of Internal Medicine, Division of Physical Therapy, Institute of Health Sciences, Hiroshima University School of Medicine, Hiroshima, Japan
    Hypertension 37:651-7. 2001
    ..These findings suggest that continued ERT improves forearm resistance artery endothelial function in postmenopausal women and that this beneficial effect is greater in patients that are hypertensive...
  4. ncbi request reprint A noninvasive measurement of reactive hyperemia that can be used to assess resistance artery endothelial function in humans
    Y Higashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    Am J Cardiol 87:121-5, A9. 2001
    ..This noninvasive method of evaluating reactive hyperemia is a useful alternative to intra-arterial infusions of vasoactive agents in the assessment of resistance vessels' endothelial function in forearm circulation...
  5. ncbi request reprint A comparison of angiotensin-converting enzyme inhibitors, calcium antagonists, beta-blockers and diuretic agents on reactive hyperemia in patients with essential hypertension: a multicenter study
    Y Higashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    J Am Coll Cardiol 35:284-91. 2000
    ..The purpose of this study was to compare the effect of different antihypertensive agents, calcium antagonists, angiotensin-converting enzyme (ACE) inhibitors, beta-blockers and diuretic agents on endothelial function...
  6. ncbi request reprint Regular aerobic exercise augments endothelium-dependent vascular relaxation in normotensive as well as hypertensive subjects: role of endothelium-derived nitric oxide
    Y Higashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    Circulation 100:1194-202. 1999
    ..We studied the effects of long-term aerobic exercise on endothelial function in patients with essential hypertension...
  7. ncbi request reprint Effect of L-arginine infusion on systemic and renal hemodynamics in hypertensive patients
    Y Higashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    Am J Hypertens 12:8-15. 1999
    ....
  8. ncbi request reprint Aging and severity of hypertension attenuate endothelium-dependent renal vascular relaxation in humans
    Y Higashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, Minami Ku, Japan
    Hypertension 30:252-8. 1997
    ..63, P<.001). These findings suggest that aging and hypertension may independently impair endothelium-dependent renovascular dilation and that this effect may be caused at least in part by a decrease in nitric oxide production...
  9. ncbi request reprint Daily aerobic exercise improves reactive hyperemia in patients with essential hypertension
    Y Higashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    Hypertension 33:591-7. 1999
    ..These findings suggest that through increased release of nitric oxide, continued physical exercise alleviates impairment of reactive hyperemia in patients with essential hypertension...
  10. ncbi request reprint Angiotensin-converting enzyme inhibition, but not calcium antagonism, improves a response of the renal vasculature to L-arginine in patients with essential hypertension
    Y Higashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    Hypertension 32:16-24. 1998
    ....
  11. ncbi request reprint Estrogen replacement therapy in postmenopausal women augments reactive hyperemia in the forearm by reducing angiotensin converting enzyme activity
    M Sanada
    Department of Obstetrics and Gynecology, School of Medicine, Faculty of Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, Japan
    Atherosclerosis 158:391-7. 2001
    ..This was likely due, at least in part, to ACE inhibition. The latter may be one mechanism by which ERT provides its well-known cardiovascular benefit...
  12. ncbi request reprint Sodium chloride loading does not alter endothelium-dependent vasodilation of forearm vasculature in either salt-sensitive or salt-resistant patients with essential hypertension
    Y Higashi
    First Department of Internal Medicine, Hiroshima University Faculty of Medicine, Japan
    Hypertens Res 24:711-6. 2001
    ....
  13. ncbi request reprint Effect of obesity on endothelium-dependent, nitric oxide-mediated vasodilation in normotensive individuals and patients with essential hypertension
    Y Higashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    Am J Hypertens 14:1038-45. 2001
    ..012), HOMA index (P = .002), and mean BP (P < .001). These findings suggest that obesity and hypertension are independently involved in abnormal endothelium-dependent vasodilation by attenuated nitric oxide production...
  14. ncbi request reprint Non-dipper phenomenon in essential hypertension is related to blunted nocturnal rise and fall of sympatho-vagal nervous activity and progress in retinopathy
    Y Nakano
    Department of Clinical Laboratory Medicine, Hiroshima University School of Medicine, Japan
    Auton Neurosci 88:181-6. 2001
    ..In conclusion, decrease in parasympathetic nervous function and increase in sympathetic nervous function may contribute to occurrence of non-dipper phenomenon, as well as progress in retinopathy...
  15. ncbi request reprint Effects of angiotensin-(1-7) on forearm circulation in normotensive subjects and patients with essential hypertension
    S Sasaki
    First Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    Hypertension 38:90-4. 2001
    ..These findings suggest that Ang-(1-7) causes vasodilation in forearm circulation of normotensive subjects and patients with essential hypertension through a pathway that is independent of nitric oxide synthesis...
  16. ncbi request reprint Calorie restriction reduced blood pressure in obesity hypertensives by improvement of autonomic nerve activity and insulin sensitivity
    Y Nakano
    Department of Clinical Laboratory Medicine, Hiroshima University School of Medicine, Japan
    J Cardiovasc Pharmacol 38:S69-74. 2001
    ..1) was significant after a low-calorie diet. In conclusion, weight loss by low-calorie diet with a constant intake of sodium, reduced blood pressure in obese hypertensives by improvement of vagal nervous activity and insulin resistance...
  17. ncbi request reprint Abnormal magnesium status in patients with cardiovascular diseases
    S Sasaki
    First Department of Internal Medicine, Hiroshima University School of Medicine, 1 2 3 Kasumi, Minami Ku, Hiroshima, Japan 734 8551
    Clin Sci (Lond) 98:175-81. 2000
    ..Furthermore, the intracellular accumulation of Mg does not support the hypothesis of Mg deficiency in patients with essential hypertension...
  18. pmc Relation between C reactive protein concentrations and coronary microvascular endothelial function
    H Teragawa
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, Japan 734 8551
    Heart 90:750-4. 2004
    ..To determine how C reactive protein (CRP), a sensitive marker of inflammation, is related to coronary endothelial function...
  19. doi request reprint Mineralocorticoid receptor blocker eplerenone improves endothelial function and inhibits Rho-associated kinase activity in patients with hypertension
    N Fujimura
    Analysis Center of Life Science, Hiroshima University, Hiroshima, Japan
    Clin Pharmacol Ther 91:289-97. 2012
    ..There were no significant differences between the groups with respect to other parameters. The study results show that eplerenone improves endothelial function and inhibits ROCK activity in patients with essential hypertension...
  20. ncbi request reprint Detection of vascular disease risk in women by panoramic radiography
    A Taguchi
    Department of Oral and Maxillofacial Radiology, Hiroshima University Dental Hospital, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
    J Dent Res 82:838-43. 2003
    ..Dentists may be able to refer women with increased risk of vascular diseases, as well as low bone mineral density, to medical professionals for further examination by panoramic findings...
  21. ncbi request reprint N-acetyl-L-gamma-glutamyl derivatives of p-nitroaniline, sulphamethoxazole and sulphamethizole for kidney-specific drug delivery in rats
    T Murakami
    Department of Biopharmaceutics, Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Japan
    J Pharm Pharmacol 50:459-65. 1998
    ..Results related to the selectivity of tissue distribution of the derivatives and species differences are discussed...
  22. ncbi request reprint Oral estrogen replacement therapy increases forearm reactive hyperemia accompanied by increases in serum levels of nitric oxide in postmenopausal women
    M Sanada
    Department of Obstetrics and Gynecology, School of Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
    Gynecol Endocrinol 15:150-7. 2001
    ..In conclusion, the 12-week administration of oral estrogen increased forearm reactive hyperemia in postmenopausal women, probably via an increase in the production of NO...