Y Higashi

Summary

Affiliation: Hiroshima University
Country: Japan

Publications

  1. doi request reprint Rho-associated kinase activity is a predictor of cardiovascular outcomes
    Masato Kajikawa
    Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Hypertension 63:856-64. 2014
  2. doi request reprint Endothelial dysfunction and hypertension in aging
    Yukihito Higashi
    Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine RIRBM, Hiroshima University, Hiroshima, Japan
    Hypertens Res 35:1039-47. 2012
  3. doi request reprint Intima-media thickness of brachial artery, vascular function, and cardiovascular risk factors
    Yumiko Iwamoto
    Department of Cardiovascular Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Arterioscler Thromb Vasc Biol 32:2295-303. 2012
  4. doi request reprint Hyperbilirubinemia, augmentation of endothelial function, and decrease in oxidative stress in Gilbert syndrome
    Tatsuya Maruhashi
    Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Circulation 126:598-603. 2012
  5. ncbi request reprint Severity of hypertension affects improved resistance artery endothelial function by angiotensin-converting enzyme inhibition
    Yukihito Higashi
    First Department of Internal Medicine, Hiroshima University, Faculty of Medicine, Minami Ku, Japan
    J Cardiovasc Pharmacol 39:668-76. 2002
  6. doi request reprint Oral infection-inflammatory pathway, periodontitis, is a risk factor for endothelial dysfunction in patients with coronary artery disease
    Yukihito Higashi
    Department of Cardiovascular Physiology and Medicine, Hiroshima University, Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Atherosclerosis 206:604-10. 2009
  7. ncbi request reprint Excess norepinephrine impairs both endothelium-dependent and -independent vasodilation in patients with pheochromocytoma
    Yukihito Higashi
    First Department of Internal Medicine, Faculty of Medicine, Hiroshima University, Japan
    Hypertension 39:513-8. 2002
  8. ncbi request reprint Edaravone for the treatment of acute cerebral infarction: role of endothelium-derived nitric oxide and oxidative stress
    Yukihito Higashi
    Hiroshima University, Graduate School of Biomedical Sciences, Department of Cardiovascular Physiology and Medicine, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Expert Opin Pharmacother 10:323-31. 2009
  9. ncbi request reprint Endothelial function and oxidative stress in cardiovascular diseases
    Yukihito Higashi
    Department of Cardiovascular Physiology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Circ J 73:411-8. 2009
  10. ncbi request reprint Endothelial function and oxidative stress in renovascular hypertension
    Yukihito Higashi
    First Department of Internal Medicine, Hiroshima University, Faculty of Medicine, Hiroshima, Japan
    N Engl J Med 346:1954-62. 2002

Collaborators

Detail Information

Publications99

  1. doi request reprint Rho-associated kinase activity is a predictor of cardiovascular outcomes
    Masato Kajikawa
    Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Hypertension 63:856-64. 2014
    ..001). Leukocyte Rho-associated kinase activity may be a new biomarker of cardiovascular events. These findings suggest that inhibition of Rho-associated kinase activity may be a therapeutic target for prevention of cardiovascular events. ..
  2. doi request reprint Endothelial dysfunction and hypertension in aging
    Yukihito Higashi
    Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine RIRBM, Hiroshima University, Hiroshima, Japan
    Hypertens Res 35:1039-47. 2012
    ..In addition, endothelial cell senescence is also involved in aging-related endothelial dysfunction. In this review, we focus on recent findings and interactions between endothelial function, oxidative stress and hypertension in aging...
  3. doi request reprint Intima-media thickness of brachial artery, vascular function, and cardiovascular risk factors
    Yumiko Iwamoto
    Department of Cardiovascular Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Arterioscler Thromb Vasc Biol 32:2295-303. 2012
    ..The purpose of this study was to determine the relationships between IMT of the brachial artery, vascular function, and cardiovascular risk factors...
  4. doi request reprint Hyperbilirubinemia, augmentation of endothelial function, and decrease in oxidative stress in Gilbert syndrome
    Tatsuya Maruhashi
    Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Circulation 126:598-603. 2012
    ..It has been shown that bilirubin is an endogenous antioxidant. We evaluated the role of oxidative stress in endothelial function in patients with Gilbert syndrome under normal conditions without cardiovascular risk factors...
  5. ncbi request reprint Severity of hypertension affects improved resistance artery endothelial function by angiotensin-converting enzyme inhibition
    Yukihito Higashi
    First Department of Internal Medicine, Hiroshima University, Faculty of Medicine, Minami Ku, Japan
    J Cardiovasc Pharmacol 39:668-76. 2002
    ....
  6. doi request reprint Oral infection-inflammatory pathway, periodontitis, is a risk factor for endothelial dysfunction in patients with coronary artery disease
    Yukihito Higashi
    Department of Cardiovascular Physiology and Medicine, Hiroshima University, Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Atherosclerosis 206:604-10. 2009
    ..There is an association between inflammation and endothelial dysfunction. The purpose of this study was to evaluate endothelial function in patients with coronary artery disease (CAD) who had periodontitis...
  7. ncbi request reprint Excess norepinephrine impairs both endothelium-dependent and -independent vasodilation in patients with pheochromocytoma
    Yukihito Higashi
    First Department of Internal Medicine, Faculty of Medicine, Hiroshima University, Japan
    Hypertension 39:513-8. 2002
    ..62, P<0.01). These findings suggest that excess NE from pheo may predominantly impair endothelium-dependent vasodilation in humans...
  8. ncbi request reprint Edaravone for the treatment of acute cerebral infarction: role of endothelium-derived nitric oxide and oxidative stress
    Yukihito Higashi
    Hiroshima University, Graduate School of Biomedical Sciences, Department of Cardiovascular Physiology and Medicine, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Expert Opin Pharmacother 10:323-31. 2009
    ....
  9. ncbi request reprint Endothelial function and oxidative stress in cardiovascular diseases
    Yukihito Higashi
    Department of Cardiovascular Physiology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Circ J 73:411-8. 2009
    ..This review focuses on recent findings and interaction between endothelial function and oxidative stress in cardiovascular diseases...
  10. ncbi request reprint Endothelial function and oxidative stress in renovascular hypertension
    Yukihito Higashi
    First Department of Internal Medicine, Hiroshima University, Faculty of Medicine, Hiroshima, Japan
    N Engl J Med 346:1954-62. 2002
    ..We sought to determine whether renal-artery angioplasty improves endothelial dysfunction in patients with renovascular hypertension through a reduction in oxidative stress...
  11. ncbi request reprint Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger, for treatment of cardiovascular diseases
    Yukihito Higashi
    Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Japan
    Recent Pat Cardiovasc Drug Discov 1:85-93. 2006
    ..This review focuses on clinical findings and on putative mechanisms underlying the beneficial effects of the antioxidative agent edaravone on the artherosclerotic process in patients with cardiovascular diseases...
  12. ncbi request reprint Periodontal infection is associated with endothelial dysfunction in healthy subjects and hypertensive patients
    Yukihito Higashi
    Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Hypertension 51:446-53. 2008
    ....
  13. ncbi request reprint Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals
    Yukihito Higashi
    First Department of Internal Medicine, Hiroshima University, Faculty of Medicine, Japan
    Am J Hypertens 15:326-32. 2002
    ..The purpose of this study was to determine whether BH4 restores endothelium-dependent vasodilation in patients with essential hypertension...
  14. ncbi request reprint Circadian variation of blood pressure and endothelial function in patients with essential hypertension:a comparison of dippers and non-dippers
    Yukihito Higashi
    Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Japan
    J Am Coll Cardiol 40:2039-43. 2002
    ..The purpose of this study was to evaluate the relationship between the circadian blood pressure (BP) rhythm and endothelial function in patients with essential hypertension...
  15. ncbi request reprint Oxidative stress, endothelial function and angiogenesis induced by cell therapy and gene therapy
    Yukihito Higashi
    Department of Cardiovascular Physiology and Medicine, Hiroshima University Graduate School of Biomedical Sciences, Japan
    Curr Pharm Biotechnol 7:109-16. 2006
    ..In this review, we discuss the relationships between oxidative stress, endothelial function, and angiogenesis and the mechanism by which therapeutic angiogenesis improves endothelial function...
  16. ncbi request reprint Tetrahydrobiopterin improves aging-related impairment of endothelium-dependent vasodilation through increase in nitric oxide production
    Yukihito Higashi
    Department of Cardiovascular Physiology and Medicine, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Atherosclerosis 186:390-5. 2006
    ..These findings suggest that a deficiency of BH4 may be involved in the pathogenesis of disturbances in endothelium-dependent vasodilation related to aging through decrease in NO production and increase in oxidative stress...
  17. ncbi request reprint Angiotensin II type I receptor blocker and endothelial function in humans: role of nitric oxide and oxidative stress
    Yukihito Higashi
    Department of Cardiovascular Physiology and Medicine, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Curr Med Chem Cardiovasc Hematol Agents 3:133-48. 2005
    ..ARBs are also thought to prevent cardiovascular complications through an augmentation of endothelial function. In this review, we focus on recent findings and putative mechanisms of the beneficial effects of ARBs on endothelial function...
  18. ncbi request reprint Low body mass index is a risk factor for impaired endothelium-dependent vasodilation in humans: role of nitric oxide and oxidative stress
    Yukihito Higashi
    Department of Cardiovascular Physiology and Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    J Am Coll Cardiol 42:256-63. 2003
    ..The purpose of this study was to evaluate the relationship between body mass index (BMI), including low BMIs, and endothelial function...
  19. ncbi request reprint Autologous bone-marrow mononuclear cell implantation improves endothelium-dependent vasodilation in patients with limb ischemia
    Yukihito Higashi
    Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Circulation 109:1215-8. 2004
    ..The purpose of this study was to determine whether autologous bone-marrow mononuclear cell (BM-MNC) implantation improves endothelial dysfunction in patients with limb ischemia...
  20. ncbi request reprint Renal endothelial dysfunction and hypertension
    Yukihito Higashi
    Cardiovascular Division, First Department of Internal Medicine, Hiroshima University School of Medicine, 1 2 3 Kasumi, Minami Ku, 734 8551, Hiroshima, Japan
    J Diabetes Complications 16:103-7. 2002
    ..However, endothelial dysfunction in essential hypertension is reversible. We can restore endothelial function in essential hypertensive patients...
  21. doi request reprint Sarpogrelate hydrochloride, a selective 5-hydroxytryptamine(2A) antagonist, augments autologous bone marrow mononuclear cell implantation-induced improvement in endothelium-dependent vasodilation in patients with critical limb ischemia
    Yukihito Higashi
    Departments of Cardiovascular Physiology, Hiroshima University, Hiroshima, Japan
    J Cardiovasc Pharmacol 55:56-61. 2010
    ....
  22. ncbi request reprint New methods to evaluate endothelial function: method for assessing endothelial function in humans using a strain-gauge plethysmography: nitric oxide-dependent and -independent vasodilation
    Yukihito Higashi
    Department of Cardiovascular Physiology and Medicine, Hiroshima University Graduate School of Biomedical Sciences, Japan
    J Pharmacol Sci 93:399-404. 2003
    ..In this review we would like to explain in detail the methods of assessing endothelial function in humans using strain-gauge plethysmography...
  23. doi request reprint Cigarette smoking abolishes ischemic preconditioning-induced augmentation of endothelium-dependent vasodilation
    Shuji Nakamura
    Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Mimami ku, Hiroshima 734 8551, Japan
    Hypertension 53:674-81. 2009
    ..However, smoking abolishes ischemic preconditioning stimulus-induced augmentation of endothelium-dependent vasodilation...
  24. doi request reprint Endothelial function in subjects with isolated low HDL cholesterol: role of nitric oxide and circulating progenitor cells
    Yukihito Higashi
    Department of Cardiovascular Physiology and Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Am J Physiol Endocrinol Metab 298:E202-9. 2010
    ....
  25. ncbi request reprint Effect of obesity on endothelium-dependent, nitric oxide-mediated vasodilation in normotensive individuals and patients with essential hypertension
    Y Higashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    Am J Hypertens 14:1038-45. 2001
    ..012), HOMA index (P = .002), and mean BP (P < .001). These findings suggest that obesity and hypertension are independently involved in abnormal endothelium-dependent vasodilation by attenuated nitric oxide production...
  26. ncbi request reprint Sodium chloride loading does not alter endothelium-dependent vasodilation of forearm vasculature in either salt-sensitive or salt-resistant patients with essential hypertension
    Y Higashi
    First Department of Internal Medicine, Hiroshima University Faculty of Medicine, Japan
    Hypertens Res 24:711-6. 2001
    ....
  27. doi request reprint Geranylgeranylacetone, heat shock protein 90/AMP-activated protein kinase/endothelial nitric oxide synthase/nitric oxide pathway, and endothelial function in humans
    Noritaka Fujimura
    Department of Cardiovascular Medicine, Hiroshima University
    Arterioscler Thromb Vasc Biol 32:153-60. 2012
    ..The purpose of this study was to determine whether GGA enhances Hsp90 expression and augments endothelium-dependent vasodilation via upregulation of eNOS in humans...
  28. ncbi request reprint Angiotensin-converting enzyme inhibition, but not calcium antagonism, improves a response of the renal vasculature to L-arginine in patients with essential hypertension
    Y Higashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    Hypertension 32:16-24. 1998
    ....
  29. ncbi request reprint Effect of estrogen replacement therapy on endothelial function in peripheral resistance arteries in normotensive and hypertensive postmenopausal women
    Y Higashi
    First Department of Internal Medicine, Division of Physical Therapy, Institute of Health Sciences, Hiroshima University School of Medicine, Hiroshima, Japan
    Hypertension 37:651-7. 2001
    ..These findings suggest that continued ERT improves forearm resistance artery endothelial function in postmenopausal women and that this beneficial effect is greater in patients that are hypertensive...
  30. ncbi request reprint Estrogen replacement therapy in postmenopausal women augments reactive hyperemia in the forearm by reducing angiotensin converting enzyme activity
    M Sanada
    Department of Obstetrics and Gynecology, School of Medicine, Faculty of Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, Japan
    Atherosclerosis 158:391-7. 2001
    ..This was likely due, at least in part, to ACE inhibition. The latter may be one mechanism by which ERT provides its well-known cardiovascular benefit...
  31. ncbi request reprint Daily aerobic exercise improves reactive hyperemia in patients with essential hypertension
    Y Higashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    Hypertension 33:591-7. 1999
    ..These findings suggest that through increased release of nitric oxide, continued physical exercise alleviates impairment of reactive hyperemia in patients with essential hypertension...
  32. ncbi request reprint Regular aerobic exercise augments endothelium-dependent vascular relaxation in normotensive as well as hypertensive subjects: role of endothelium-derived nitric oxide
    Y Higashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    Circulation 100:1194-202. 1999
    ..We studied the effects of long-term aerobic exercise on endothelial function in patients with essential hypertension...
  33. ncbi request reprint A noninvasive measurement of reactive hyperemia that can be used to assess resistance artery endothelial function in humans
    Y Higashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    Am J Cardiol 87:121-5, A9. 2001
    ..This noninvasive method of evaluating reactive hyperemia is a useful alternative to intra-arterial infusions of vasoactive agents in the assessment of resistance vessels' endothelial function in forearm circulation...
  34. ncbi request reprint Relationship between the angiotensin-converting enzyme genotype and the forearm vasodilator response to estrogen replacement therapy in postmenopausal women
    M Sanada
    Department of Obstetrics and Gynecology, Faculty of Medicine, Hiroshima University, Japan
    J Am Coll Cardiol 37:1529-35. 2001
    ..We sought to evaluate the relationship between the angiotensin-converting enzyme (ACE) genotype and the change in forearm vasoreactivity in response to a three-month course of oral estrogen in postmenopausal women...
  35. ncbi request reprint Effect of the angiotensin-converting enzyme inhibitor imidapril on reactive hyperemia in patients with essential hypertension: relationship between treatment periods and resistance artery endothelial function
    Y Higashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    J Am Coll Cardiol 37:863-70. 2001
    ..The purpose of this study was to evaluate the effects of the angiotensin-converting enzyme (ACE) inhibitor imidapril and the calcium antagonist amlodipine on endothelial function before and after 2, 4, 8, 12, 24 and 48 weeks of treatment...
  36. ncbi request reprint A comparison of angiotensin-converting enzyme inhibitors, calcium antagonists, beta-blockers and diuretic agents on reactive hyperemia in patients with essential hypertension: a multicenter study
    Y Higashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    J Am Coll Cardiol 35:284-91. 2000
    ..The purpose of this study was to compare the effect of different antihypertensive agents, calcium antagonists, angiotensin-converting enzyme (ACE) inhibitors, beta-blockers and diuretic agents on endothelial function...
  37. ncbi request reprint Repetition of ischemic preconditioning augments endothelium-dependent vasodilation in humans: role of endothelium-derived nitric oxide and endothelial progenitor cells
    Masashi Kimura
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Mimami ku, Hiroshima 734 8551, Japan
    Arterioscler Thromb Vasc Biol 27:1403-10. 2007
    ..Several studies have shown that both early and late effects of ischemic preconditioning (IPC) protect against myocardial injury after ischemic reperfusion...
  38. ncbi request reprint Aging and severity of hypertension attenuate endothelium-dependent renal vascular relaxation in humans
    Y Higashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, Minami Ku, Japan
    Hypertension 30:252-8. 1997
    ..63, P<.001). These findings suggest that aging and hypertension may independently impair endothelium-dependent renovascular dilation and that this effect may be caused at least in part by a decrease in nitric oxide production...
  39. ncbi request reprint Adrenomedullin causes coronary vasodilation in humans: effects of inhibition of nitric oxide synthesis
    Kentaro Ueda
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Cardiovasc Pharmacol 46:534-9. 2005
    ..These findings suggest that adrenomedullin dilates human coronary arteries through an increase in NO production, at least in part...
  40. ncbi request reprint Oral estrogen replacement therapy increases forearm reactive hyperemia accompanied by increases in serum levels of nitric oxide in postmenopausal women
    M Sanada
    Department of Obstetrics and Gynecology, School of Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
    Gynecol Endocrinol 15:150-7. 2001
    ..In conclusion, the 12-week administration of oral estrogen increased forearm reactive hyperemia in postmenopausal women, probably via an increase in the production of NO...
  41. ncbi request reprint Nocturnal decline in blood pressure is attenuated by NaCl loading in salt-sensitive patients with essential hypertension: noninvasive 24-hour ambulatory blood pressure monitoring
    Y Higashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, Minami Ku, Japan
    Hypertension 30:163-7. 1997
    ..57 versus 0.26, chi2=6.4; P=.02; odds ratio, 3.82). These findings suggest that the NaCl loading blunted the nocturnal decline in blood pressure in salt-sensitive patients but not in salt-resistant patients...
  42. ncbi request reprint Acute moderate-intensity exercise induces vasodilation through an increase in nitric oxide bioavailiability in humans
    Chikara Goto
    Department of Cardiovascular Physiology and Medicine, University Graduate School of Biomedical Sciences Hiroshima, Hiroshima, Japan
    Am J Hypertens 20:825-30. 2007
    ..The purpose of this study was to determine the effects of different intensities of acute exercise on hemodynamics in humans...
  43. ncbi request reprint PDE5 inhibitor sildenafil citrate augments endothelium-dependent vasodilation in smokers
    Masashi Kimura
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Hypertension 41:1106-10. 2003
    ....
  44. ncbi request reprint Vascular function in patients with lower extremity peripheral arterial disease: a comparison of functions in upper and lower extremities
    Hiroaki Sanada
    Department of Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Atherosclerosis 178:179-85. 2005
    ....
  45. ncbi request reprint Effect of L-arginine infusion on systemic and renal hemodynamics in hypertensive patients
    Y Higashi
    First Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    Am J Hypertens 12:8-15. 1999
    ....
  46. ncbi request reprint Calorie restriction reduced blood pressure in obesity hypertensives by improvement of autonomic nerve activity and insulin sensitivity
    Y Nakano
    Department of Clinical Laboratory Medicine, Hiroshima University School of Medicine, Japan
    J Cardiovasc Pharmacol 38:S69-74. 2001
    ..1) was significant after a low-calorie diet. In conclusion, weight loss by low-calorie diet with a constant intake of sodium, reduced blood pressure in obese hypertensives by improvement of vagal nervous activity and insulin resistance...
  47. ncbi request reprint Effects of angiotensin-(1-7) on forearm circulation in normotensive subjects and patients with essential hypertension
    S Sasaki
    First Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    Hypertension 38:90-4. 2001
    ..These findings suggest that Ang-(1-7) causes vasodilation in forearm circulation of normotensive subjects and patients with essential hypertension through a pathway that is independent of nitric oxide synthesis...
  48. ncbi request reprint Response of the left anterior descending coronary artery to acetylcholine in patients with chest pain and angiographically normal coronary arteries
    Keiji Matsuda
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Am J Cardiol 92:1394-8. 2003
    ....
  49. ncbi request reprint Effect of different intensities of exercise on endothelium-dependent vasodilation in humans: role of endothelium-dependent nitric oxide and oxidative stress
    Chikara Goto
    Physical Therapy Health Sciences, School of Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Circulation 108:530-5. 2003
    ..The purpose of the present study was to determine the effects of different intensities of exercise on endothelium-dependent vasodilation in humans...
  50. ncbi request reprint Effects of acute administration of caffeine on vascular function
    Takashi Umemura
    Department of Cardiovascular Physiology and Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Am J Cardiol 98:1538-41. 2006
    ..In conclusion, these findings suggest that the acute administration of caffeine augments endothelium-dependent vasodilation in healthy young men through an increase in nitric oxide production...
  51. ncbi request reprint Sarpogrelate hydrochloride, a selective 5-HT2A antagonist, improves vascular function in patients with peripheral arterial disease
    Masanori Miyazaki
    Department of Surgery, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    J Cardiovasc Pharmacol 49:221-7. 2007
    ..The changes in FBF and LBF after sublingual NTG were similar during follow-up periods in the 2 groups. These findings suggest that long-term oral administration of sarpogrelate improves vascular function in patients with PAD...
  52. ncbi request reprint Smoking, endothelial function, and Rho-kinase in humans
    Kensuke Noma
    Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734 8551, Japan
    Arterioscler Thromb Vasc Biol 25:2630-5. 2005
    ..The purpose of this study was to elucidate the relationship between endothelial function and Rho-kinase activity in forearm VSMCs in healthy young men...
  53. ncbi request reprint Hormone replacement effects on endothelial function measured in the forearm resistance artery in normocholesterolemic and hypercholesterolemic postmenopausal women
    Mitsuhiro Sanada
    Department of Obstetrics and Gynecology, Faculty of Medicine, Hiroshima University, Hiroshima 734 8551, Japan
    J Clin Endocrinol Metab 87:4634-41. 2002
    ..5%; P < 0.05). Changes in the FBF with NTG were not altered by HRT in either group. Long-term HRT augments endothelial function in forearm resistance artery. This beneficial effect is greater in patients with hypercholesterolemia...
  54. ncbi request reprint Effect of alcohol consumption on endothelial function in men with coronary artery disease
    Hiroki Teragawa
    First Department of Internal Medicine, Hiroshima University School of Medicine, 1 2 3 Kasumi, Minamiku, Hiroshima 734 8551, Japan
    Atherosclerosis 165:145-52. 2002
    ..Multiple regression analysis showed alcohol consumption to be one of the factors favorably influencing FMD. These findings suggest that alcohol consumption may improve endothelial function in men with CAD...
  55. ncbi request reprint Non-dipper phenomenon in essential hypertension is related to blunted nocturnal rise and fall of sympatho-vagal nervous activity and progress in retinopathy
    Y Nakano
    Department of Clinical Laboratory Medicine, Hiroshima University School of Medicine, Japan
    Auton Neurosci 88:181-6. 2001
    ..In conclusion, decrease in parasympathetic nervous function and increase in sympathetic nervous function may contribute to occurrence of non-dipper phenomenon, as well as progress in retinopathy...
  56. ncbi request reprint Abnormal magnesium status in patients with cardiovascular diseases
    S Sasaki
    First Department of Internal Medicine, Hiroshima University School of Medicine, 1 2 3 Kasumi, Minami Ku, Hiroshima, Japan 734 8551
    Clin Sci (Lond) 98:175-81. 2000
    ..Furthermore, the intracellular accumulation of Mg does not support the hypothesis of Mg deficiency in patients with essential hypertension...
  57. ncbi request reprint Forearm endothelial function and bone mineral loss in postmenopausal women
    Mitsuhiro Sanada
    Department of Obstetrics and Gynecology, Sanada Hospital, Graduate School of Biomedical Sciences, Hiroshima University, 3 13 21 Minami machi, Minami Ku, Hiroshima 734 0007, Japan
    Atherosclerosis 176:387-92. 2004
    ..The present findings suggest that postmenopausal women with low BMD, especially those with osteoporosis, have impaired endothelial function in the forearm resistance arteries...
  58. ncbi request reprint A low-calorie diet improves endothelium-dependent vasodilation in obese patients with essential hypertension
    Shota Sasaki
    First Department of Internal Medicine, Hiroshima University, Faculty of Medicine, Japan
    Am J Hypertens 15:302-9. 2002
    ..Both obesity and hypertension are associated with endothelial dysfunction. The purpose of this study was to investigate the effects of a low-calorie diet on endothelial function in obese patients with essential hypertension...
  59. ncbi request reprint Pycnogenol, French maritime pine bark extract, augments endothelium-dependent vasodilation in humans
    Kenji Nishioka
    Department of Cardiovascular Physiology and Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Hypertens Res 30:775-80. 2007
    ..These findings suggest that Pycnogenol augments endothelium-dependent vasodilation by increasing in NO production. Pycnogenol would be useful for treating various diseases whose pathogeneses involve endothelial dysfunction...
  60. ncbi request reprint Smoking activates rho-kinase in smooth muscle cells of forearm vasculature in humans
    Kensuke Noma
    Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Hypertension 41:1102-5. 2003
    ..2+/-10.2 mL/min per 100 mL tissue; P=0.78). These findings suggest that smoking activates Rho-kinase in forearm VSMCs but does not alter the vasodilatory effect induced by exogenous nitric oxide in forearm VSMCs in healthy young men...
  61. ncbi request reprint Comparison of forearm endothelial function between premenopausal and postmenopausal women with or without hypercholesterolemia
    Mitsuhiro Sanada
    Department of Obstetrics and Gynecology, Faculty of Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Maturitas 44:307-15. 2003
    ..These findings suggest that reactive hyperemia is impaired in forearm resistance arteries after menopause, especially in postmenopausal women with hypercholesterolemia...
  62. ncbi request reprint Leptin causes nitric-oxide independent coronary artery vasodilation in humans
    Keiji Matsuda
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Hypertens Res 26:147-52. 2003
    ..Leptin-induced coronary vasodilation was not affected by the infusion of L-NMMA. These results suggest that leptin dilates coronary arteries in humans. Furthermore, EDNO may not contribute to leptin-induced coronary dilation...
  63. ncbi request reprint Leptin causes vasodilation in humans
    Keigo Nakagawa
    First Department of Internal Medicine, Hiroshima University Faculty of Medicine, Japan
    Hypertens Res 25:161-5. 2002
    ..2+/-5.4, -11.1+/-2.5% at 1, 10 and 100 ng/kg/min of leptin, respectively) to leptin. These findings suggest that leptin per se directly causes vasodilation and that leptin-induced vasodilatation is nitric oxide-independent in healthy men...
  64. doi request reprint Mineralocorticoid receptor blocker eplerenone improves endothelial function and inhibits Rho-associated kinase activity in patients with hypertension
    N Fujimura
    Analysis Center of Life Science, Hiroshima University, Hiroshima, Japan
    Clin Pharmacol Ther 91:289-97. 2012
    ..There were no significant differences between the groups with respect to other parameters. The study results show that eplerenone improves endothelial function and inhibits ROCK activity in patients with essential hypertension...
  65. ncbi request reprint Effect of edaravone, a novel free radical scavenger, on endothelium-dependent vasodilation in smokers
    Daisuke Jitsuiki
    Department of Cardiovascular Physiology and Medicine, Hiroshima University, Hiroshima, Japan
    Am J Cardiol 94:1070-3. 2004
    ..The antioxidative agent edaravone increases nitric oxide mediated vasodilation through a decrease in oxidative stress...
  66. doi request reprint Pioglitazone improves endothelium-dependent vasodilation in hypertensive patients with impaired glucose tolerance in part through a decrease in oxidative stress
    Takayuki Hidaka
    Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Atherosclerosis 210:521-4. 2010
    ..The aim of this study was to determine pioglitazone treatment restores endothelial function in hypertensive patients with impaired glucose tolerance (IGT)...
  67. pmc Relation between C reactive protein concentrations and coronary microvascular endothelial function
    H Teragawa
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, Japan 734 8551
    Heart 90:750-4. 2004
    ..To determine how C reactive protein (CRP), a sensitive marker of inflammation, is related to coronary endothelial function...
  68. doi request reprint Aging and hypertension are independent risk factors for reduced number of circulating endothelial progenitor cells
    Takashi Umemura
    Department of Cardiovascular Physiology and Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Am J Hypertens 21:1203-9. 2008
    ..The purpose of this study was to evaluate the relationship between the number of EPCs and cardiovascular risk factors...
  69. ncbi request reprint Measurement of flow-mediated vasodilation of the brachial artery: a comparison of measurements in the seated and supine positions
    Junko Soga
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Minami Ku, Kiroshima, Japan
    Circ J 71:736-40. 2007
    ..However, measurement of FMD while seated would be more comfortable and convenient for patients, so the purpose of this study was to determine the effect of the patient's position on FMD results...
  70. ncbi request reprint [Endothelial function]
    Yukihito Higashi
    Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical Sciences, Hiroshima University
    Nihon Rinsho 61:1138-44. 2003
    ..It is unclear that endothelial dysfunction is a cause or consequence of hypertension. In this review, we present the possibility that endothelial dysfunction causes hypertension in diabetes mellitus...
  71. doi request reprint Coronary vasospasm produces reversible perfusion defects observed during adenosine triphosphate stress myocardial single-photon emission computed tomography
    Hiroki Teragawa
    Department of Medicine and Molecular Science, Hiroshima University Hospital, Hiroshima, Japan
    Clin Cardiol 31:310-6. 2008
    ..It has not been established whether a coronary spasm is responsible for the false positive findings during ATP-SPECT...
  72. ncbi request reprint Beneficial effect of T-type calcium channel blockers on endothelial function in patients with essential hypertension
    Tetsuya Oshima
    Department of Clinical Laboratory Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Hypertens Res 28:889-94. 2005
    ..These results suggest that a T-type Ca2+ channel blocker, but not an L-type Ca2+ channel blocker, may improve vascular endothelial dysfunction in patients with essential hypertension via a reduction in oxidative stress...
  73. pmc Increased leukocyte rho kinase (ROCK) activity and endothelial dysfunction in cigarette smokers
    Takayuki Hidaka
    Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Hypertens Res 33:354-9. 2010
    ..There was a significant correlation between FMD and ROCK activity (r=-0.42, P=0.035). No other variable was correlated with FMD. These findings suggest that ROCK activity is enhanced by smoking and is a predictor of endothelial function...
  74. ncbi request reprint Apolipoprotein E phenotype affects the malondialdehyde-modified LDL concentration and forearm endothelial function in postmenopausal women
    Mikio Tsuda
    Department of Obstetrics and Gynaecology, Graduate School of Biomedical Science, Hiroshima University, Hiorshima, Japan
    Clin Endocrinol (Oxf) 61:619-25. 2004
    ..We investigated whether the apolipoprotein E (apo E) phenotype affects the serum concentration of malondialdehyde-modified low-density lipoprotein (MDA-LDL) or forearm endothelial function in postmenopausal women...
  75. ncbi request reprint Relationship between endothelial function in the coronary and brachial arteries
    Hiroki Teragawa
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Japan
    Clin Cardiol 28:460-6. 2005
    ..Endothelial dysfunction is the first step in the progression to atherosclerosis, but little is known regarding whether there is a correlation in endothelial function between the coronary and peripheral arteries...
  76. ncbi request reprint Autologous bone marrow mononuclear cell implantation induces angiogenesis and bone regeneration in a patient with compartment syndrome
    Takashi Umemura
    Department of Cardiovascular Physiology, Hiroshima University Graduate School of Biomedical Sciences, Kasumi, Hiroshima, Japan
    Circ J 70:1362-4. 2006
    ..BMMNC implantation therapy might provide therapeutic angiogenesis and osteogensis in patients with compartment syndrome...
  77. ncbi request reprint Myocardial bridging increases the risk of coronary spasm
    Hiroki Teragawa
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Clin Cardiol 26:377-83. 2003
    ..Myocardial bridging (MB) has been associated with cardiac events. Whether coronary spasm is one factor contributing to those events is unknown...
  78. ncbi request reprint Effect of amlodipine and cilazapril treatment on platelet Ca2+ handling in spontaneously hypertensive rats
    Tetsuya Oshima
    Department of Clinical Laboratory of Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Hypertens Res 26:901-6. 2003
    ..These results support the hypothesis that an abnormal Ca2+ handling in SHR platelet is genetically determined and not improved by hypotensive therapy...
  79. ncbi request reprint Interaction of obesity and skeletal bone mineral density in tooth retention in Japanese postmenopausal women
    Akira Taguchi
    Department of Oral and Maxillofacial Radiology, Hiroshima University Hospital, Minami Ku, Japan
    Menopause 14:500-4. 2007
    ..To investigate whether being overweight is associated with increased or decreased risk of tooth loss in Japanese postmenopausal women...
  80. ncbi request reprint Association of Helicobacter pylori infection with systemic inflammation and endothelial dysfunction in healthy male subjects
    Tetsuya Oshima
    Department of Clinical Laboratory Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    J Am Coll Cardiol 45:1219-22. 2005
    ....
  81. ncbi request reprint Tooth loss is associated with an increased risk of hypertension in postmenopausal women
    Akira Taguchi
    Department of Oral and Maxillofacial Radiology, Hiroshima University Hospital, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
    Hypertension 43:1297-300. 2004
    ..7) after adjustment of obesity, hypercholesterolemia, and hypertriglyceridemia. Our results suggest that hypertension may be an important factor linking tooth loss and an increased risk of vascular diseases in postmenopausal women...
  82. pmc Roles of rho-associated kinase and oxidative stress in the pathogenesis of aortic stiffness
    Kensuke Noma
    Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Am Coll Cardiol 49:698-705. 2007
    ..The purpose of this study was to determine the relationship between Rho-associated kinase (ROCK) activity and aortic stiffness in humans...
  83. doi request reprint Relationship between augmentation index and flow-mediated vasodilation in the brachial artery
    Junko Soga
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Hypertens Res 31:1293-8. 2008
    ..05). These findings suggest that increase in arterial stiffness may be associated with grade of endothelial dysfunction and that AI may be an index of not only arterial stiffness but also endothelial function...
  84. ncbi request reprint A comparison of low-dose and standard-dose oral estrogen on forearm endothelial function in early postmenopausal women
    Mitsuhiro Sanada
    Department of Obstetrics and Gynecology, Faculty of Medicine, Hiroshima University, Hiroshima 734 8551, Japan
    J Clin Endocrinol Metab 88:1303-9. 2003
    ..Low-dose CEE plus MPA augments endothelial function in forearm resistance arteries and decreased MDA-modified LDL levels similarly to standard doses of CEE plus MPA, with fewer side effects...
  85. ncbi request reprint Combination therapy of low-dose medroxyprogesterone acetate and oral estrogen does not affect endothelial function in the forearms of postmenopausal women
    Mitsuhiro Sanada
    Department of Obstetrics and Gynecology, Faculty of Medicine, Hiroshima University, Hiroshima, Japan
    Menopause 9:360-6. 2002
    ..We investigated whether low-dose medroxyprogesterone acetate (MPA) combined with oral estrogen had adverse effects on endothelial function compared with oral estrogen alone in postmenopausal women with mild hypercholesterolemia...
  86. ncbi request reprint [Oxidative stress, reactive oxygen species]
    Yukihito Higashi
    Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical Sciences, Hiroshima University
    Nihon Rinsho 62:49-55. 2004
    ..In this review, we would like to explain the role of oxidative stress in hypertensive organ damages...
  87. ncbi request reprint Exercise and endothelial function: role of endothelium-derived nitric oxide and oxidative stress in healthy subjects and hypertensive patients
    Yukihito Higashi
    Department of Cardiovascular Physiology and Medicine, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami, Hiroshima 734 8551, Japan
    Pharmacol Ther 102:87-96. 2004
    ..In this review, we will focus on recent findings and on possible mechanisms underlying the beneficial effects of exercise on endothelial function in patients with hypertension...
  88. ncbi request reprint Detection of vascular disease risk in women by panoramic radiography
    A Taguchi
    Department of Oral and Maxillofacial Radiology, Hiroshima University Dental Hospital, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
    J Dent Res 82:838-43. 2003
    ..Dentists may be able to refer women with increased risk of vascular diseases, as well as low bone mineral density, to medical professionals for further examination by panoramic findings...
  89. ncbi request reprint Selection of common markers for bone marrow stromal cells from various bones using real-time RT-PCR: effects of passage number and donor age
    Akira Igarashi
    Department of Dental and Medical Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Tissue Eng 13:2405-17. 2007
    ..This marker set may be useful in a routine test for BMSCs in tissue engineering and cell therapy...
  90. ncbi request reprint N-acetyl-L-gamma-glutamyl derivatives of p-nitroaniline, sulphamethoxazole and sulphamethizole for kidney-specific drug delivery in rats
    T Murakami
    Department of Biopharmaceutics, Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Japan
    J Pharm Pharmacol 50:459-65. 1998
    ..Results related to the selectivity of tissue distribution of the derivatives and species differences are discussed...
  91. doi request reprint Vascular function and circulating progenitor cells in thromboangitis obliterans (Buerger's disease) and atherosclerosis obliterans
    Naomi Idei
    Department of Cardiovascular Physiology and Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Hypertension 57:70-8. 2011
    ..These findings may partially explain why there are differences in cardiovascular morbidity and mortality rates between patients with TAO and patients with ASO...
  92. ncbi request reprint [Vascular endothelium dysfunction as the first phase of arteriosclerosis]
    Yukihito Higashi
    Nihon Naika Gakkai Zasshi 96:1717-23. 2007
  93. pmc Carvedilol improves endothelium-dependent vasodilation in patients with dilated cardiomyopathy
    Kenji Nishioka
    Heart 93:247-8. 2007
  94. ncbi request reprint The nicorandil-induced vasodilation in humans is inhibited by miconazole
    Keiko Ueda
    Department of Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Cardiovasc Pharmacol 45:290-4. 2005
    ..EDHF may contribute to nicorandil-induced vasodilation in humans...
  95. ncbi request reprint Molecular markers distinguish bone marrow mesenchymal stem cells from fibroblasts
    Masakazu Ishii
    Department of Dental and Medical Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Biochem Biophys Res Commun 332:297-303. 2005
    ..The marker genes identified in this study should be useful for characterization of MSC both in basic and clinical studies...
  96. ncbi request reprint Endothelial progenitor cells: therapeutic target for cardiovascular diseases
    Takashi Umemura
    Department of Cardiovascular Physiology and Medicine, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima, Japan
    J Pharmacol Sci 108:1-6. 2008
    ..In this review, we focus on the relationship between EPCs and cardiovascular risk factors and the role of EPCs in cardiovascular diseases...
  97. ncbi request reprint Commentary on Viewpoint: Exercise and cardiovascular risk reduction: time to update the rationale for exercise?
    Yukihito Higashi
    J Appl Physiol 105:770. 2008
  98. ncbi request reprint Images in cardiovascular medicine. Corkscrew collaterals in thromboangitis obliterans (Buerger's disease)
    Yuichi Fujii
    Department of Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Circulation 116:e539-40. 2007
  99. ncbi request reprint [Calcium antagonists and insulin resistance]
    Yukihito Higashi
    Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical Sciences, Hirosima University
    Clin Calcium 15:1675-80. 2005
    ..In this review, we would like to focus on the effects of calcium antagonists on insulin resistance (insulin sensitivity)...