Research Topics
Species | Michihiro HideSummaryAffiliation: Hiroshima University Country: Japan Publications
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Detail Information
Publications
[Cholinergic urticaria successfully treated by immunotherapy with partially purified sweat antigen]Toshihiko Tanaka
Department of Dermatology, Graduate School of Biomedical Sciences, Hiroshima University
Arerugi 56:54-7. 2007..Specific immunotherapy using sweat antigen may be valuable for patients with cholinergic urticaria with type I hypersensitivity to sweat antigen(s)...- Community validation of the U.K. diagnostic criteria for atopic dermatitis in Japanese elementary schoolchildrenHidehisa Saeki
Department of Dermatology, Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
J Dermatol Sci 47:227-31. 2007..K. working party. This list served well for both hospital patients with skin diseases and in general population within the U.K... - Cutaneous mast cell receptorsMichihiro Hide
Department of Dermatology, Programs for Biomedical Research, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
Dermatol Clin 25:563-75, ix. 2007..MC(T) and MC(TC) are different in their granular neutral proteases, tissue localizations, and functions. This article describes the differences between the cutaneous mast cell receptors... - IgE-mediated hypersensitivity against human sweat antigen in patients with atopic dermatitisMichihiro Hide
Department of Dermatology, Graduate School of Biomedical Sciences, Hiroshima University, Japan
Acta Derm Venereol 82:335-40. 2002..IgE antibody against antigen(s) in sweat may be present in serum of patients with atopic dermatitis. Key words:.. - [Urticaria-up to date]Michihiro Hide
Department of Dermatology, Graduate School of Biomedical Sciences Hiroshima University, Hiroshima, Japan
Arerugi 53:409-12. 2004 
Hydrolyzed Konjac glucomannan suppresses IgE production in mice B cellsHidenori Suzuki
Department of Dermatology, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Minami Ku, Hiroshima, Japan
Int Arch Allergy Immunol 152:122-30. 2010..To elucidate the mechanism of action of pulverized KGM, we solubilized KGM and studied its effect on IgE in vitro and in vivo...- Dietary pulverized konjac glucomannan prevents the development of allergic rhinitis-like symptoms and IgE response in miceNobukazu Onishi
Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, Japan
Biosci Biotechnol Biochem 71:2551-6. 2007..These results suggest that PKGM can be a beneficial foodstuff in preventing nasal allergy such as seasonal pollinosis... - Histamine release-neutralization assay for sera of patients with atopic dermatitis and/or cholinergic urticaria is useful to screen type I hypersensitivity against sweat antigensHajime Shindo
Programs for Biomedical Research, Division of Molecular Medical Science, Department of Dermatology, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi, Minami Ku, Hiroshima, Japan
Arch Dermatol Res 304:647-54. 2012..Thus, the HRN assay maybe useful for the screening of type I allergy against sweat antigen... - Applying surface plasmon resonance to monitor the IgE-mediated activation of human basophilsHidenori Suzuki
Department of Dermatology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
Allergol Int 57:347-58. 2008..To overcome potential shortcomings of the histamine releasing test, we applied surface plasmon resonance (SPR) to detect the activation of basophils... - Peritoneal injection of fucoidan suppresses the increase of plasma IgE induced by OVA-sensitizationYuhki Yanase
Department of Dermatology, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3, Kasumi, Minami Ku, Hiroshima, Japan
Biochem Biophys Res Commun 387:435-9. 2009..These results indicate that fucoidan inhibits the increase of plasma IgE through the suppression of IgE-producing B cell population, and the effect of fucoidan in vivo is crucially dependent on the route and timing of its administration... - Fucoidan suppresses IgE production in peripheral blood mononuclear cells from patients with atopic dermatitisKazumasa Iwamoto
Division of Molecular Medical Science, Department of Dermatology, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8551, Japan
Arch Dermatol Res 303:425-31. 2011..Our findings indicate that fucoidan suppresses IgE induction by inhibiting immunoglobulin class-switching to IgE in human B cells, even after the onset of AD... - Evaluation of peripheral blood basophil activation by means of surface plasmon resonance imagingYuhki Yanase
Department of Dermatology, Division of Molecular Medical Science, Graduate School of Biomedical Science, Hiroshima University, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
Biosens Bioelectron 32:62-8. 2012..In combination with a device to rapidly isolate basophils from peripheral blood, this technique may be a useful tool as a high throughput screening system in clinical diagnosis for type I allergy... - The extract of syngeneic keratinocytes enhances IgE production from BALB/c mouse splenic lymphocytes in vitroKenichi Morimoto
Department of Dermatology, Division of Molecular Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3, Kasumi, 734-8551 Hiroshima, Japan
Arch Dermatol Res 297:358-66. 2006..Such enhancement may account for the increase of serum IgE in patients with dermatitis in association with a Th2 microenvironment... - Bone marrow derived mast cell acquire responsiveness to substance P with Ca(2+) signals and release of leukotriene B(4) via mitogen-activated protein kinaseTsutomu Okabe
Department of Dermatology, Hiroshima University School of Medicine, 1 2 3 Kasumi, Minamiku, Hiroshima 734 8551, Japan
J Neuroimmunol 181:1-12. 2006..These results suggest that mast cells undergo maturation under the influence of fibroblasts, acquiring the responsiveness to SP with Ca(2+) signals and predominantly ERK-MAP kinase... - [Taking showers at school is beneficial for children with severer atopic dermatitis]Yoshikazu Kameyoshi
Department of Dermatology, Graduate shool of Biomedical Sciences, Hiroshima University
Arerugi 57:130-7. 2008..Sweat(ing) is a common aggravating factor of atopic dermatitis (AD), and many school children with AD experience the exacerbation of their disease in summer... - Pressure challenge test and histopathological inspections for 17 Japanese cases with clinically diagnosed delayed pressure urticariaSatoshi Morioke
Department of Dermatology, Hiroshima University, Minami Ku, Japan
Arch Dermatol Res 302:613-7. 2010..DPU may be identified as a relatively rare complication of Japanese patients with chronic idiopathic urticaria. A proper diagnosis and a small amount of steroid may be beneficial for the treatment of DPU... - Development of autoantibody responses in NC/Nga mice: its prevention by pulverized konjac glucomannan feedingNobukazu Onishi
Department of Research and Development, Nishikawa Rubber Co Ltd, Hiroshima, Japan
Arch Dermatol Res 300:95-9. 2008..Our results imply the possible involvement of autoimmunity on the pathogenesis of dermatitis and hyper-IgE syndrome in NC/Nga mice. PKGM might be effective in preventing autoimmune responses in AD... - [Efficacy of sweat-antigen-inactivating skin care products on itching of patients with atopic dermatitis]Hajime Shindo
Department of Dermatology, Graduate School of Biomedical Sciences, Hiroshima University, Japan
Arerugi 60:33-42. 2011..We had searched a substance that inactivated sweat antigen adopting histamine release test. And we found that tannic acid which selected by screening various natural products inactivated sweat antigen... - Dietary pulverized konjac glucomannan suppresses scratching behavior and skin inflammatory immune responses in NC/Nga miceNobukazu Onishi
Department of Research and Development, Nishikawa Rubber Co Ltd, Hiroshima, Japan
Int Arch Allergy Immunol 144:95-104. 2007..This study aimed to examine the effects of PKGM on scratching behavior and skin inflammatory immune responses in NC/Nga mice... - [The sensitivity and clinical course of patients with wheat-dependent exercise-induced anaphylaxis sensitized to hydrolyzed wheat protein in facial soap]Makiko Hiragun
Division of Molecular Medical Science, Department of Dermatology, Graduate School of Biomedical Sciences, Hiroshima University
Arerugi 60:1630-40. 2011..Recently an increasing number of patients with wheat-dependent exercise-induced anaphylaxis (WDEIA), developed during or after using hydrolyzed wheat protein (HWP)-containing soap (HWP-WDEIA), were reported in Japan... - Detection of refractive index changes in individual living cells by means of surface plasmon resonance imagingYuhki Yanase
Department of Dermatology, Programs for Biomedical Research, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
Biosens Bioelectron 26:674-81. 2010..This system may be a useful tool to investigate the mechanism of refractive index-changes evoked in near-membrane fields of living cells, and to develop a system of high-throughput screening for clinical diagnosis... - A critical role of conventional protein kinase C in morphological changes of rodent mast cellsYuhki Yanase
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
Immunol Cell Biol 89:149-59. 2011..In addition, BMMC adhesion by and migration toward stem cell factor were shown to be dependent on cPKC. Thus, cPKC, at least PKCĪ² subtype, may be critical for the dynamic morphological changes that lead to the migration of mast cells... - Living cell positioning on the surface of gold film for SPR analysisYuhki Yanase
Department of Dermatology, Programs for Biomedical Research, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
Biosens Bioelectron 23:562-7. 2007..Thus, the methods of cell fixation and removal with HydroCell or RepCell should enable us to analyze various reactions in either adherent or non-adherent cells by SPR... - Surface plasmon resonance biosensor detects the downstream events of active PKCbeta in antigen-stimulated mast cellsMaiko Tanaka
Department of Dermatology, Graduate School of Biomedical Sciences, Hiroshima University, Minami Ku, Hiroshima 734 8551, Japan
Biosens Bioelectron 23:1652-8. 2008..These results indicate that the activation of Syk, LAT, Gads, and subsequent PKCbeta is indispensable for the antigen-induced increase of AR of mast cells detected by SPR biosensors... - Development of an optical fiber SPR sensor for living cell activationYuhki Yanase
Department of Dermatology, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Minami Ku, Hiroshima, Japan
Biosens Bioelectron 25:1244-7. 2010..This small fiber SPR system might serve as a useful tool for various clinical examinations either within or outside the body... - Six cases of antihistamine-resistant dermographic urticaria treated with oral ciclosporinSayuri Toda
Department of Dermatology, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima, Japan
Allergol Int 60:547-50. 2011..H(1)-receptor antagonists may reduce symptoms of DU to some extent, but other treatments being used for chronic spontaneous urticaria, such as H(2)-receptor antagonists and corticosteroids, are not usually effective for DU... - Surface plasmon resonance-biosensor detects the diversity of responses against epidermal growth factor in various carcinoma cell linesTakaaki Hiragun
Department of Dermatology, Programs for Biomedical Research, Division of Molecular Medical Science, Hiroshima University, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
Biosens Bioelectron 32:202-7. 2012..These results suggest that EGF induces the SPR signals via the phosphorylation of EGFR, and provide a possibility that the SPR biosensor could be applied to the real-time detection and diagnosis of malignant tumors... - [Ebm and future direction of allergen-specific immunotherapy for atopic dermatitis]Shoji Mihara
Department of Dermatology, Programs for Biomedical Research, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University
Arerugi 57:499-506. 2008 - A case of lower-extremity deep burn wounds with periosteal necrosis successfully treated by use of allogenic cultured dermal substituteNaoki Ohara
Programs for Biomedical Research, Division of Molecular Medical Science, Department of Dermatology, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8551, Japan
J Artif Organs 13:101-5. 2010..Finally, all wounds healed without osteomyelitis. The use of CDS to treat deep burns exposing bone surface may expand reconstructive options for extremities that otherwise might have been amputated... - [National prevalence survey of hereditary angioedema in Japan]Kazumasa Iwamoto
Department of Dermatology, Programs for Biomedical Research, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Japan
Arerugi 60:26-32. 2011..The prevalence of hereditary angioedema (HAE) is estimated to be approximately 1 case per 50000 persons in English literatures. However, neither disease prevalence nor epidemiologic features of HAE has been surveyed in Japan... - [Analysis of the prevalence of subtypes of urticaria and angioedema]Toshihiko Tanaka
Department of Dermatology, Division of Molecular Medical Science, Programsfor Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University
Arerugi 55:134-9. 2006..The prevalence of various subtypes of urticaria in Japan has not been analyzed... - IL-4 modulates the histamine content of mast cells in a mast cell/fibroblast co-culture through a Stat6 signaling pathway in fibroblastsYukiko Nabeshima
Department of Dermatology, Programs for Biomedical Research, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
FEBS Lett 579:6653-8. 2005.... - The effectiveness of montelukast for the treatment of anti-histamine-resistant chronic urticariaSeiko Sanada
Department of Dermatology, Programs for Biomedical Research, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8551, Japan
Arch Dermatol Res 297:134-8. 2005..9+/-15.0 years, 89.6+/-71.7 months). Montelukast may be worth trying for patients with chronic idiopathic urticaria, when the condition is not sufficiently controlled with histamine H(1)-receptor antagonists... - [Two cases of food-dependent exercise-induced anaphylaxis difficult to evoke symptoms by provocation test]Kenichi Morimoto
Department of Dermatology, Division of Molecular Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University
Arerugi 55:1433-6. 2006..Frigidity, cold, prostration, and stress should be reckoned with in the provocation test to improve the accuracy of diagnosis for FDEIA... - The SPR signal in living cells reflects changes other than the area of adhesion and the formation of cell constructionsYuhki Yanase
Department of Dermatology Programs for Biomedical Research, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Minami Ku, Hiroshima 734 8551, Japan
Biosens Bioelectron 22:1081-6. 2007..These results suggest that AR changes reflect intracellular events rather than changes in the size of the area to which cells adhere... - Increase in serum IgE levels following injection of syngeneic keratinocyte extracts in BALB/c miceTadashi Yamamoto
Department of Dermatology, Hiroshima University Faculty of Medicine, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
Arch Dermatol Res 294:117-23. 2002..These results suggest that the release of the soluble fraction of keratinocytes and its exposure to immunologically competent cells may induce an increase in serum IgE levels by a Th2-dominant mechanism... - Japanese guidelines for diagnosis and treatment of urticaria in comparison with other countriesMichihiro Hide
Department of Dermatology, Institute of Biomedical and Health Sciences, Hiroshima University, Japan
Allergol Int 61:517-27. 2012..In this article, the outline of the newest guidelines by JDA are introduced and compared with the guidelines in other countries published in English... - Mizoribine treatment for antihistamine-resistant chronic autoimmune urticariaTakashi Hashimoto
Department of Dermatology, Kurume University School of Medicine and Kurume University Institute of Cutaneous Cell Biology, Kurume, Japan
Dermatol Ther 25:379-81. 2012..We suggest that mizoribine might help to reduce anti-IgE autoantibody acting on the surface of basophils in chronic autoimmune urticaria... - Metastatic extramammary Paget's disease treated with paclitaxel and trastuzumab combination chemotherapyShunsuke Takahagi
Department of Dermatology, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Minami Ku, Hiroshima, Japan
J Dermatol 36:457-61. 2009..Trastuzumab and paclitaxel-combination with the assessment of central nervous system lesions should be considered as an option for the treatment of HER2-positive EMPD... - Pelodera strongyloides infestation presenting as pruritic dermatitisAkio Tanaka
Department of Dermatology, Graduate School of Biomedical Sciences, Hiroshima University, Japan
J Am Acad Dermatol 51:S181-4. 2004..Skin scrapings revealed many live rhabditiform larvae that were cultured adult worms and hatched ova, identified as P strongyloides . The eruption was treated effectively with topical 1% gamma-hexachlorocyclohexane ointment... - A randomized double-blind trial of intravenous immunoglobulin for pemphigusMasayuki Amagai
Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
J Am Acad Dermatol 60:595-603. 2009..It has been difficult to conduct a double-blind clinical study for pemphigus partly because, in a placebo group, appropriate treatment often must be provided when the disease flares... - Anaphylaxis after dental treatment with a formaldehyde-containing tooth-filling materialYukiko Nabeshima
Acta Derm Venereol 84:497-8. 2004 - Fucoidan prevents C epsilon germline transcription and NFkappaB p52 translocation for IgE production in B cellsSouichi Oomizu
Hiroshima Prefectural Institute of Industrial Science and Technology, Higashi Hiroshima, Japan
Biochem Biophys Res Commun 350:501-7. 2006..These results suggest that fucoidan inhibited IgE production by preventing the NFkappaB p52-mediated pathways activated by CD40... - Food-dependent exercise-induced anaphylaxis due to ingestion of orangeKenichi Morimoto
Acta Derm Venereol 84:152-3. 2004 - Food-dependent exercise-induced anaphylaxis due to ingestion of appleKenichi Morimoto
J Dermatol 32:62-3. 2005 - Anaphylactic shock caused by exposure to sea anemonesKeiko Nagata
Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan
Allergol Int 55:181-4. 2006.... - Real-time analysis of ligand-induced cell surface and intracellular reactions of living mast cells using a surface plasmon resonance-based biosensorMichihiro Hide
Tissue Regeneration Project, Hiroshima Prefecture Collaboration of Regional Entities for the Advancement of Technological Excellence, Japan
Anal Biochem 302:28-37. 2002..We concluded that SPR sensors can detect biologically significant signals in a real-time manner from the interactions between cells and molecules reactive to the cells...