S Hama

Summary

Affiliation: Hiroshima University
Country: Japan

Publications

  1. pmc p16 Gene transfer increases cell killing with abnormal nucleation after ionising radiation in glioma cells
    S Hama
    Department of Neurosurgery, Hiroshima University School of Medicine, Kasumi 1 2 3, Minami Ku, Hiroshima 734 8551, Japan
    Br J Cancer 89:1802-11. 2003
  2. ncbi request reprint Changes in the epithelium of Rathke cleft cyst associated with inflammation
    Seiji Hama
    Department of Neurosurgery, Hiroshima University School of Medicine, Japan
    J Neurosurg 96:209-16. 2002
  3. ncbi request reprint Expression of survivin in astrocytic tumors: correlation with malignant grade and prognosis
    Yoshinori Kajiwara
    Department of Neurosurgery, Faculty of Medicine, Hiroshima University, Hiroshima, Japan
    Cancer 97:1077-83. 2003
  4. pmc Centrosome amplification induced by survivin suppression enhances both chromosome instability and radiosensitivity in glioma cells
    T Saito
    Department of Neurosurgery, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Br J Cancer 98:345-55. 2008
  5. ncbi request reprint Absence of mutations in the NBS1 gene in B-cell malignant lymphoma patients
    S Hama
    Department of Radiation Biology, Hiroshima University, Japan
    Anticancer Res 20:1897-900. 2000
  6. ncbi request reprint Survivin subcellular localization in high-grade astrocytomas: simultaneous expression in both nucleus and cytoplasm is negative prognostic marker
    Taiichi Saito
    Department of Neurosurgery, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8551, Japan
    J Neurooncol 82:193-8. 2007
  7. ncbi request reprint Geminin: a good prognostic factor in high-grade astrocytic brain tumors
    Prabin Shrestha
    Department of Neurosurgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Cancer 109:949-56. 2007
  8. ncbi request reprint Retinoblastoma protein prevents staurosporine-induced cell death in a retinoblastoma-defective human glioma cell line
    Fumiyuki Yamasaki
    Department of Neurosurgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Pathobiology 74:22-31. 2007
  9. ncbi request reprint Sitting balance as an early predictor of functional improvement in association with depressive symptoms in stroke patients
    Seiji Hama
    Department of Rehabilitation, Nishi Hiroshima Rehabilitation Hospital, Hiroshima, Japan
    Psychiatry Clin Neurosci 61:543-51. 2007
  10. ncbi request reprint The combination of low cytoplasmic and high nuclear expression of p27 predicts a better prognosis in high-grade astrocytoma
    Toshikazu Hidaka
    Department of Neurosurgery, Graduate School of Biomedical Sciences, Hiroshima University, Japan
    Anticancer Res 29:597-603. 2009

Collaborators

Detail Information

Publications22

  1. pmc p16 Gene transfer increases cell killing with abnormal nucleation after ionising radiation in glioma cells
    S Hama
    Department of Neurosurgery, Hiroshima University School of Medicine, Kasumi 1 2 3, Minami Ku, Hiroshima 734 8551, Japan
    Br J Cancer 89:1802-11. 2003
    ..Thus, p16 expression prevented radiation-induced apoptosis by promoting abnormal nucleation, thereby leading to another mode of cell death...
  2. ncbi request reprint Changes in the epithelium of Rathke cleft cyst associated with inflammation
    Seiji Hama
    Department of Neurosurgery, Hiroshima University School of Medicine, Japan
    J Neurosurg 96:209-16. 2002
    ..Rathke cleft cysts (RCCs) are composed of tall, well-differentiated, ciliated columnar epithelia. Their structures are altered by hyperplasia or squamous metaplasia, but their cause remains unknown...
  3. ncbi request reprint Expression of survivin in astrocytic tumors: correlation with malignant grade and prognosis
    Yoshinori Kajiwara
    Department of Neurosurgery, Faculty of Medicine, Hiroshima University, Hiroshima, Japan
    Cancer 97:1077-83. 2003
    ..Recently, survivin has been identified as a member of the inhibitor-of-apoptosis family. Survivin expression is considered an important prognostic factor of many tumors...
  4. pmc Centrosome amplification induced by survivin suppression enhances both chromosome instability and radiosensitivity in glioma cells
    T Saito
    Department of Neurosurgery, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Br J Cancer 98:345-55. 2008
    ....
  5. ncbi request reprint Absence of mutations in the NBS1 gene in B-cell malignant lymphoma patients
    S Hama
    Department of Radiation Biology, Hiroshima University, Japan
    Anticancer Res 20:1897-900. 2000
    ..To determine whether the NBS1 gene is a tumor suppressor gene in B-cell lymphoma, we screened B-cell malignant lymphoma (ML) for any evidence of NBS1 mutation...
  6. ncbi request reprint Survivin subcellular localization in high-grade astrocytomas: simultaneous expression in both nucleus and cytoplasm is negative prognostic marker
    Taiichi Saito
    Department of Neurosurgery, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8551, Japan
    J Neurooncol 82:193-8. 2007
    ..The aim of the present study was to examine the relationship between prognosis and subcellular localization of survivin in high-grade astrocytoma...
  7. ncbi request reprint Geminin: a good prognostic factor in high-grade astrocytic brain tumors
    Prabin Shrestha
    Department of Neurosurgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Cancer 109:949-56. 2007
    ....
  8. ncbi request reprint Retinoblastoma protein prevents staurosporine-induced cell death in a retinoblastoma-defective human glioma cell line
    Fumiyuki Yamasaki
    Department of Neurosurgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Pathobiology 74:22-31. 2007
    ..To investigate the mechanism of staurosporine-induced glioma cell death and cell cycle arrest using adenovirus-mediated gene transfection, as well as the function of retinoblastoma (Rb) and genetic instability induced by staurosporine...
  9. ncbi request reprint Sitting balance as an early predictor of functional improvement in association with depressive symptoms in stroke patients
    Seiji Hama
    Department of Rehabilitation, Nishi Hiroshima Rehabilitation Hospital, Hiroshima, Japan
    Psychiatry Clin Neurosci 61:543-51. 2007
    ..A rapid and simple screening method, 10-min sitting balance was related to scores for two core depressive symptoms, lowered mood and apathy, and was predictive of post-stroke ADL outcomes in the rehabilitation unit along with age...
  10. ncbi request reprint The combination of low cytoplasmic and high nuclear expression of p27 predicts a better prognosis in high-grade astrocytoma
    Toshikazu Hidaka
    Department of Neurosurgery, Graduate School of Biomedical Sciences, Hiroshima University, Japan
    Anticancer Res 29:597-603. 2009
    ..No previous reports have examined the subcellular localization of p27 in glioma which was evaluated here regarding the prognosis in high-grade astrocytomas...
  11. doi request reprint 'Insistence on recovery' as a positive prognostic factor in Japanese stroke patients
    Seiji Hama
    Department of Rehabilitation, Nishi Hiroshima Rehabilitation Hospital, Hiroshima, Japan
    Psychiatry Clin Neurosci 62:386-95. 2008
    ..The present study used two-step analyses to examine the effect of acceptance of disability or 'insistence on recovery' in Japanese stroke patients: first on their functional improvement and second, on their psychological symptoms...
  12. ncbi request reprint Prognosis of cerebellar glioblastomas: correlation between prognosis and immunoreactivity for epidermal growth factor receptor compared with supratentorial glioblastomas
    Taiichi Saito
    Department of Neurosurgery, Hiroshima University, School of Medicine, Hiroshima, 734 8551, Japan
    Anticancer Res 26:1351-7. 2006
    ..Cerebellar glioblastomas (GBM) are rare tumors whose clinicopathological characteristics are not well understood...
  13. ncbi request reprint Cytoplasmic, but not nuclear, p16 expression may signal poor prognosis in high-grade astrocytomas
    Muhamad Thohar Arifin
    Department of Neurosurgery, Research Institute for Radiation Biology and Medicine, Graduate School of Medical Sciences, Hiroshima University, Hiroshima shi, Japan
    J Neurooncol 77:273-7. 2006
    ..The negative consequences of the cytoplasmic localization of p16 in patients with high-grade astrocytomas, on their prognosis, was investigated...
  14. ncbi request reprint Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome
    Shinya Matsuura
    Department of Radiation Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
    Am J Med Genet A 140:358-67. 2006
    ..These findings indicate the involvement of BubR1 in p55cdc-mediated mitotic checkpoint signaling, and suggest that >50% decrease in expression (or activity) of BubR1 is involved in the PCS syndrome...
  15. ncbi request reprint Staurosporine-induced apoptosis is independent of p16 and p21 and achieved via arrest at G2/M and at G1 in U251MG human glioma cell line
    Fumiyuki Yamasaki
    Department of Neurosurgery, Faculty of Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, Japan
    Cancer Chemother Pharmacol 51:271-83. 2003
    ..The mechanisms involved in the cell cycle and cell death remain unresolved despite much investigation. Staurosporine induces cell death and G1 or G2/M arrest in a dose-dependent manner, but the mechanisms remain unknown...
  16. ncbi request reprint Size-adjustable titanium plate for reconstruction of the sella turcica. Technical note
    K Arita
    Department of Neurosurgery, Hiroshima University School of Medicine, Japan
    J Neurosurg 91:1055-7. 1999
    ..Preliminary findings indicate a possible clinical use for this plate in the reconstruction of the sella turcica when no suitable piece of bone is available...
  17. ncbi request reprint Detection and differentiation of lactate and lipids by single-voxel proton MR spectroscopy
    Fumiyuki Yamasaki
    Department of Neurosurgery, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Hiroshima, 734 8551, Japan
    Neurosurg Rev 28:267-77. 2005
    ..With our method of varying the TE, it is possible accurately and efficiently to detect lactate and lipids in the brain. We found a significant correlation between lactate and lipid expression and WHO grade of neuro-epithelial tumors...
  18. ncbi request reprint Relationship between intratumoral hemorrhage and overexpression of vascular endothelial growth factor (VEGF) in pituitary adenoma
    Kazunori Arita
    Department of Neurosurgery, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Hiroshima J Med Sci 53:23-7. 2004
    ..In conclusion, a positive relationship between VEGF expression and hemorrhage in pituitary adenoma was observed. The patho-mechanical significance of this correlation is under investigation...
  19. ncbi request reprint Malnutrition and nonthyroidal illness syndrome after stroke
    Seiji Hama
    Division of Rehabilitation, Nishi Hiroshima Rehabilitation Hospital, Hiroshima 731 5143, Japan
    Metabolism 54:699-704. 2005
    ..Therefore, during the recovery period after stroke, it is important to determine whether NTIS is present and ensure proper intensive rehabilitation and nutritional management...
  20. ncbi request reprint Apparent diffusion coefficient of human brain tumors at MR imaging
    Fumiyuki Yamasaki
    Dept of Neurosurgery, Graduate School of Biomedical Sciences, Hiroshima Univ, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Radiology 235:985-91. 2005
    ..To determine if apparent diffusion coefficient (ADC) can be used to differentiate brain tumors at magnetic resonance (MR) imaging...
  21. ncbi request reprint Depression or apathy and functional recovery after stroke
    Seiji Hama
    Department of Rehabilitation, Nishi Hiroshima Rehabilitation Hospital, Hiroshima, Japan
    Int J Geriatr Psychiatry 22:1046-51. 2007
    ..This study was designed to examine the effect of depression or apathy on functional recovery after stroke in 237 Japanese stroke patients...
  22. ncbi request reprint Preparation of purified, sterilized, and stable adenovirus vectors using albumin
    Mami Hosokawa
    Department of Medical Oncology and Clinical Research, National Shikoku Cancer Center, 13 Horinocuhi, Matsuyama, Ehime, Japan
    J Virol Methods 103:191-9. 2002
    ..Furthermore, viral activity was retained within the 1% albumin solution for at least 1 week at 37 degrees C and for 2 weeks at 4 degrees C, whereas viral activity within the albumin-free solution was quickly lost...