Research Topics
Species | S HamaSummaryAffiliation: Hiroshima University Country: Japan Publications
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Detail Information
Publications
p16 Gene transfer increases cell killing with abnormal nucleation after ionising radiation in glioma cellsS Hama
Department of Neurosurgery, Hiroshima University School of Medicine, Kasumi 1 2 3, Minami Ku, Hiroshima 734 8551, Japan
Br J Cancer 89:1802-11. 2003..Thus, p16 expression prevented radiation-induced apoptosis by promoting abnormal nucleation, thereby leading to another mode of cell death...
Changes in the epithelium of Rathke cleft cyst associated with inflammationSeiji Hama
Department of Neurosurgery, Hiroshima University School of Medicine, Japan
J Neurosurg 96:209-16. 2002..Rathke cleft cysts (RCCs) are composed of tall, well-differentiated, ciliated columnar epithelia. Their structures are altered by hyperplasia or squamous metaplasia, but their cause remains unknown...- Expression of survivin in astrocytic tumors: correlation with malignant grade and prognosisYoshinori Kajiwara
Department of Neurosurgery, Faculty of Medicine, Hiroshima University, Hiroshima, Japan
Cancer 97:1077-83. 2003..Recently, survivin has been identified as a member of the inhibitor-of-apoptosis family. Survivin expression is considered an important prognostic factor of many tumors... - Centrosome amplification induced by survivin suppression enhances both chromosome instability and radiosensitivity in glioma cellsT Saito
Department of Neurosurgery, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
Br J Cancer 98:345-55. 2008.... - Absence of mutations in the NBS1 gene in B-cell malignant lymphoma patientsS Hama
Department of Radiation Biology, Hiroshima University, Japan
Anticancer Res 20:1897-900. 2000..To determine whether the NBS1 gene is a tumor suppressor gene in B-cell lymphoma, we screened B-cell malignant lymphoma (ML) for any evidence of NBS1 mutation... - Survivin subcellular localization in high-grade astrocytomas: simultaneous expression in both nucleus and cytoplasm is negative prognostic markerTaiichi Saito
Department of Neurosurgery, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8551, Japan
J Neurooncol 82:193-8. 2007..The aim of the present study was to examine the relationship between prognosis and subcellular localization of survivin in high-grade astrocytoma... - Geminin: a good prognostic factor in high-grade astrocytic brain tumorsPrabin Shrestha
Department of Neurosurgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
Cancer 109:949-56. 2007.... - Retinoblastoma protein prevents staurosporine-induced cell death in a retinoblastoma-defective human glioma cell lineFumiyuki Yamasaki
Department of Neurosurgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
Pathobiology 74:22-31. 2007..To investigate the mechanism of staurosporine-induced glioma cell death and cell cycle arrest using adenovirus-mediated gene transfection, as well as the function of retinoblastoma (Rb) and genetic instability induced by staurosporine... - Sitting balance as an early predictor of functional improvement in association with depressive symptoms in stroke patientsSeiji Hama
Department of Rehabilitation, Nishi Hiroshima Rehabilitation Hospital, Hiroshima, Japan
Psychiatry Clin Neurosci 61:543-51. 2007..A rapid and simple screening method, 10-min sitting balance was related to scores for two core depressive symptoms, lowered mood and apathy, and was predictive of post-stroke ADL outcomes in the rehabilitation unit along with age... - The combination of low cytoplasmic and high nuclear expression of p27 predicts a better prognosis in high-grade astrocytomaToshikazu Hidaka
Department of Neurosurgery, Graduate School of Biomedical Sciences, Hiroshima University, Japan
Anticancer Res 29:597-603. 2009..No previous reports have examined the subcellular localization of p27 in glioma which was evaluated here regarding the prognosis in high-grade astrocytomas... 
'Insistence on recovery' as a positive prognostic factor in Japanese stroke patientsSeiji Hama
Department of Rehabilitation, Nishi Hiroshima Rehabilitation Hospital, Hiroshima, Japan
Psychiatry Clin Neurosci 62:386-95. 2008..The present study used two-step analyses to examine the effect of acceptance of disability or 'insistence on recovery' in Japanese stroke patients: first on their functional improvement and second, on their psychological symptoms...- Prognosis of cerebellar glioblastomas: correlation between prognosis and immunoreactivity for epidermal growth factor receptor compared with supratentorial glioblastomasTaiichi Saito
Department of Neurosurgery, Hiroshima University, School of Medicine, Hiroshima, 734 8551, Japan
Anticancer Res 26:1351-7. 2006..Cerebellar glioblastomas (GBM) are rare tumors whose clinicopathological characteristics are not well understood... - Cytoplasmic, but not nuclear, p16 expression may signal poor prognosis in high-grade astrocytomasMuhamad Thohar Arifin
Department of Neurosurgery, Research Institute for Radiation Biology and Medicine, Graduate School of Medical Sciences, Hiroshima University, Hiroshima shi, Japan
J Neurooncol 77:273-7. 2006..The negative consequences of the cytoplasmic localization of p16 in patients with high-grade astrocytomas, on their prognosis, was investigated... - Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndromeShinya Matsuura
Department of Radiation Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
Am J Med Genet A 140:358-67. 2006..These findings indicate the involvement of BubR1 in p55cdc-mediated mitotic checkpoint signaling, and suggest that >50% decrease in expression (or activity) of BubR1 is involved in the PCS syndrome... - Staurosporine-induced apoptosis is independent of p16 and p21 and achieved via arrest at G2/M and at G1 in U251MG human glioma cell lineFumiyuki Yamasaki
Department of Neurosurgery, Faculty of Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, Japan
Cancer Chemother Pharmacol 51:271-83. 2003..The mechanisms involved in the cell cycle and cell death remain unresolved despite much investigation. Staurosporine induces cell death and G1 or G2/M arrest in a dose-dependent manner, but the mechanisms remain unknown... - Size-adjustable titanium plate for reconstruction of the sella turcica. Technical noteK Arita
Department of Neurosurgery, Hiroshima University School of Medicine, Japan
J Neurosurg 91:1055-7. 1999..Preliminary findings indicate a possible clinical use for this plate in the reconstruction of the sella turcica when no suitable piece of bone is available... - Detection and differentiation of lactate and lipids by single-voxel proton MR spectroscopyFumiyuki Yamasaki
Department of Neurosurgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Hiroshima, 734-8551, Japan
Neurosurg Rev 28:267-77. 2005..With our method of varying the TE, it is possible accurately and efficiently to detect lactate and lipids in the brain. We found a significant correlation between lactate and lipid expression and WHO grade of neuro-epithelial tumors... - Relationship between intratumoral hemorrhage and overexpression of vascular endothelial growth factor (VEGF) in pituitary adenomaKazunori Arita
Department of Neurosurgery, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
Hiroshima J Med Sci 53:23-7. 2004..In conclusion, a positive relationship between VEGF expression and hemorrhage in pituitary adenoma was observed. The patho-mechanical significance of this correlation is under investigation... - Malnutrition and nonthyroidal illness syndrome after strokeSeiji Hama
Division of Rehabilitation, Nishi Hiroshima Rehabilitation Hospital, Hiroshima 731 5143, Japan
Metabolism 54:699-704. 2005..Therefore, during the recovery period after stroke, it is important to determine whether NTIS is present and ensure proper intensive rehabilitation and nutritional management... - Apparent diffusion coefficient of human brain tumors at MR imagingFumiyuki Yamasaki
Dept of Neurosurgery, Graduate School of Biomedical Sciences, Hiroshima Univ, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
Radiology 235:985-91. 2005..CONCLUSION: ADC is useful for differentiation of some human brain tumors, particularly DNT, malignant lymphomas versus glioblastomas and metastatic tumors, and ependymomas versus PNETs... - Depression or apathy and functional recovery after strokeSeiji Hama
Department of Rehabilitation, Nishi Hiroshima Rehabilitation Hospital, Hiroshima, Japan
Int J Geriatr Psychiatry 22:1046-51. 2007..This study was designed to examine the effect of depression or apathy on functional recovery after stroke in 237 Japanese stroke patients... - Preparation of purified, sterilized, and stable adenovirus vectors using albuminMami Hosokawa
Department of Medical Oncology and Clinical Research, National Shikoku Cancer Center, 13-Horinocuhi, Matsuyama, Ehime, Japan
J Virol Methods 103:191-9. 2002..Furthermore, viral activity was retained within the 1% albumin solution for at least 1 week at 37 degrees C and for 2 weeks at 4 degrees C, whereas viral activity within the albumin-free solution was quickly lost...