Kazuaki Chayama

Summary

Affiliation: Hiroshima University
Country: Japan

Publications

  1. ncbi Treatment of chronic hepatitis C virus infection in Japan: update on therapy and guidelines
    Kazuaki Chayama
    Laboratory for Digestive Diseases, Center for Genomic Medicine, RIKEN, Hiroshima, Japan
    J Gastroenterol 48:1-12. 2013
  2. ncbi Dual therapy with the nonstructural protein 5A inhibitor, daclatasvir, and the nonstructural protein 3 protease inhibitor, asunaprevir, in hepatitis C virus genotype 1b-infected null responders
    Kazuaki Chayama
    Hiroshima University, Hiroshima, Japan
    Hepatology 55:742-8. 2012
  3. ncbi Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population
    Yoshio Sumida
    Center for Digestive and Liver Diseases, Nara City Hospital, Nara, Japan
    BMC Gastroenterol 12:2. 2012
  4. ncbi IL28B but not ITPA polymorphism is predictive of response to pegylated interferon, ribavirin, and telaprevir triple therapy in patients with genotype 1 hepatitis C
    Kazuaki Chayama
    Laboratory for Digestive Diseases, Center for Genomic Medicine, RIKEN, Japan
    J Infect Dis 204:84-93. 2011
  5. ncbi Animal model for study of human hepatitis viruses
    Kazuaki Chayama
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Japan Liver Research Project Center, Hiroshima, Japan
    J Gastroenterol Hepatol 26:13-8. 2011
  6. ncbi Hepatitis C virus: How genetic variability affects pathobiology of disease
    Kazuaki Chayama
    Department of Medicine and Molecular Science, Hiroshima University, Japan
    J Gastroenterol Hepatol 26:83-95. 2011
  7. ncbi Factors predictive of sustained virological response following 72 weeks of combination therapy for genotype 1b hepatitis C
    Kazuaki Chayama
    Department of Medical and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Gastroenterol 46:545-55. 2011
  8. ncbi Emergence of a novel lamivudine-resistant hepatitis B virus variant with a substitution outside the YMDD motif
    Hiromi Yatsuji
    Department of Medical and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Science, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Antimicrob Agents Chemother 50:3867-74. 2006
  9. ncbi HCV substitutions and IL28B polymorphisms on outcome of peg-interferon plus ribavirin combination therapy
    C Nelson Hayes
    Laboratory for Digestive Diseases, Center for Genomic Medicine, RIKEN, Hiroshima, Japan
    Gut 60:261-7. 2011
  10. ncbi Antibodies to Helicobacter pylori and CagA protein are associated with the response to antibacterial therapy in patients with H. pylori-positive API2-MALT1-negative gastric MALT lymphoma
    Tomonori Sumida
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Cancer Sci 100:1075-81. 2009

Detail Information

Publications135 found, 100 shown here

  1. ncbi Treatment of chronic hepatitis C virus infection in Japan: update on therapy and guidelines
    Kazuaki Chayama
    Laboratory for Digestive Diseases, Center for Genomic Medicine, RIKEN, Hiroshima, Japan
    J Gastroenterol 48:1-12. 2013
    ..In this review we summarize current treatment options in Japan and discuss how we treat patients with chronic HCV infection...
  2. ncbi Dual therapy with the nonstructural protein 5A inhibitor, daclatasvir, and the nonstructural protein 3 protease inhibitor, asunaprevir, in hepatitis C virus genotype 1b-infected null responders
    Kazuaki Chayama
    Hiroshima University, Hiroshima, Japan
    Hepatology 55:742-8. 2012
    ..CONCLUSIONS: Dual therapy with daclatasvir and asunaprevir, without Peg-IFN and RBV, can achieve high SVR rates in difficult-to-treat patients with HCV genotype 1b infection and previous null response to Peg-IFN and RBV...
  3. ncbi Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population
    Yoshio Sumida
    Center for Digestive and Liver Diseases, Nara City Hospital, Nara, Japan
    BMC Gastroenterol 12:2. 2012
    ..We validated the performance of FIB4 index in a Japanese cohort with NAFLD...
  4. ncbi IL28B but not ITPA polymorphism is predictive of response to pegylated interferon, ribavirin, and telaprevir triple therapy in patients with genotype 1 hepatitis C
    Kazuaki Chayama
    Laboratory for Digestive Diseases, Center for Genomic Medicine, RIKEN, Japan
    J Infect Dis 204:84-93. 2011
    ....
  5. ncbi Animal model for study of human hepatitis viruses
    Kazuaki Chayama
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Japan Liver Research Project Center, Hiroshima, Japan
    J Gastroenterol Hepatol 26:13-8. 2011
    ..Various therapeutic agents have also been tested using this model. In the present review, we summarize published studies using chimeric mice and discuss the merits and shortcomings of this model...
  6. ncbi Hepatitis C virus: How genetic variability affects pathobiology of disease
    Kazuaki Chayama
    Department of Medicine and Molecular Science, Hiroshima University, Japan
    J Gastroenterol Hepatol 26:83-95. 2011
    ..We also discuss amino acid substitutions within specific regions that have been reported to be associated with outcome of IFN and peg-IFN plus ribavirin combination therapy...
  7. ncbi Factors predictive of sustained virological response following 72 weeks of combination therapy for genotype 1b hepatitis C
    Kazuaki Chayama
    Department of Medical and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Gastroenterol 46:545-55. 2011
    ....
  8. ncbi Emergence of a novel lamivudine-resistant hepatitis B virus variant with a substitution outside the YMDD motif
    Hiromi Yatsuji
    Department of Medical and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Science, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Antimicrob Agents Chemother 50:3867-74. 2006
    ..In conclusion, although the incidence is not high, we have to be careful regarding the emergence of lamivudine-resistant mutant strains with intact YMDD motif...
  9. ncbi HCV substitutions and IL28B polymorphisms on outcome of peg-interferon plus ribavirin combination therapy
    C Nelson Hayes
    Laboratory for Digestive Diseases, Center for Genomic Medicine, RIKEN, Hiroshima, Japan
    Gut 60:261-7. 2011
    ..Multiple logistic regression was used to determine whether host and viral polymorphisms independently predict sustained virological response (SVR)...
  10. ncbi Antibodies to Helicobacter pylori and CagA protein are associated with the response to antibacterial therapy in patients with H. pylori-positive API2-MALT1-negative gastric MALT lymphoma
    Tomonori Sumida
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Cancer Sci 100:1075-81. 2009
    ..In conclusion, measurement of titers of serum antibodies to H. pylori and CagA protein may be useful for predicting the response to eradication therapy in patients with H. pylori-positive API2-MALT1-negative gastric MALT lymphoma...
  11. ncbi Repetition of ischemic preconditioning augments endothelium-dependent vasodilation in humans: role of endothelium-derived nitric oxide and endothelial progenitor cells
    Masashi Kimura
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Mimami ku, Hiroshima 734 8551, Japan
    Arterioscler Thromb Vasc Biol 27:1403-10. 2007
    ..Several studies have shown that both early and late effects of ischemic preconditioning (IPC) protect against myocardial injury after ischemic reperfusion...
  12. ncbi Dose comparison study of pegylated interferon-alpha-2b plus ribavirin in naïve Japanese patients with hepatitis C virus genotype 2: a randomized clinical trial
    Tomokazu Kawaoka
    Department of Medicine and Molecular Science, Hiroshima University, Minami Ku, Hiroshima, Japan
    J Gastroenterol Hepatol 24:366-71. 2009
    ..To compare the efficacy and safety of pegylated interferon (PEG-I) at 1 and 1.5 microg/kg, and in combination with ribavirin (RBV) for 24 weeks in naïve Japanese patients infected with hepatitis C virus genotype 2...
  13. ncbi Acute moderate-intensity exercise induces vasodilation through an increase in nitric oxide bioavailiability in humans
    Chikara Goto
    Department of Cardiovascular Physiology and Medicine, University Graduate School of Biomedical Sciences Hiroshima, Hiroshima, Japan
    Am J Hypertens 20:825-30. 2007
    ..The purpose of this study was to determine the effects of different intensities of acute exercise on hemodynamics in humans...
  14. ncbi Smoking, endothelial function, and Rho-kinase in humans
    Kensuke Noma
    Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8551, Japan
    Arterioscler Thromb Vasc Biol 25:2630-5. 2005
    ....
  15. ncbi Pycnogenol, French maritime pine bark extract, augments endothelium-dependent vasodilation in humans
    Kenji Nishioka
    Department of Cardiovascular Physiology and Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Hypertens Res 30:775-80. 2007
    ..These findings suggest that Pycnogenol augments endothelium-dependent vasodilation by increasing in NO production. Pycnogenol would be useful for treating various diseases whose pathogeneses involve endothelial dysfunction...
  16. ncbi Adrenomedullin causes coronary vasodilation in humans: effects of inhibition of nitric oxide synthesis
    Kentaro Ueda
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Cardiovasc Pharmacol 46:534-9. 2005
    ..These findings suggest that adrenomedullin dilates human coronary arteries through an increase in NO production, at least in part...
  17. ncbi PDE5 inhibitor sildenafil citrate augments endothelium-dependent vasodilation in smokers
    Masashi Kimura
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Hypertension 41:1106-10. 2003
    ....
  18. ncbi Interleukin-28B single nucleotide polymorphism of donors and recipients can predict viral response to pegylated interferon/ribavirin therapy in patients with recurrent hepatitis C after living donor liver transplantation
    Tomokazu Kawaoka
    Department of Medicine and Molecular Science, Hiroshima University, Hiroshima, Japan
    J Gastroenterol Hepatol 27:1467-72. 2012
    ..We studied the relationship between VR and the IL28B polymorphism (rs8099917) in patients on long-term pegylated IFN plus ribavirin (PEGIFN/RBV) therapy for recurrent hepatitis C after living-donor liver transplantation (LDLT)...
  19. ncbi Intima-media thickness of brachial artery, vascular function, and cardiovascular risk factors
    Yumiko Iwamoto
    Department of Cardiovascular Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Arterioscler Thromb Vasc Biol 32:2295-303. 2012
    ..The purpose of this study was to determine the relationships between IMT of the brachial artery, vascular function, and cardiovascular risk factors...
  20. ncbi Achievement of sustained viral response after switching treatment from pegylated interferon α-2b to α-2a and ribavirin in patients with recurrence of hepatitis C virus genotype 1 infection after liver transplantation: a case report
    Tomokazu Kawaoka
    Department of Medicine and Molecular Science, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan
    Intervirology 55:306-10. 2012
    ..However, breakthrough viremia occurred. PEG-IFN was thus switched from α-2b to α-2a and RBV for another 17 months. The patient eventually achieved a sustained viral response...
  21. ncbi Periodontal infection is associated with endothelial dysfunction in healthy subjects and hypertensive patients
    Yukihito Higashi
    Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Hypertension 51:446-53. 2008
    ....
  22. ncbi Low body mass index is a risk factor for impaired endothelium-dependent vasodilation in humans: role of nitric oxide and oxidative stress
    Yukihito Higashi
    Department of Cardiovascular Physiology and Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    J Am Coll Cardiol 42:256-63. 2003
    ..The purpose of this study was to evaluate the relationship between body mass index (BMI), including low BMIs, and endothelial function...
  23. ncbi Effects of a 24-week course of interferon-alpha therapy after curative treatment of hepatitis C virus-associated hepatocellular carcinoma
    Soo Cheol Jeong
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    World J Gastroenterol 13:5343-50. 2007
    ....
  24. ncbi Amino acid substitutions in core and NS5A regions of the HCV genome can predict virological decrease with pegylated interferon plus ribavirin therapy
    Shosuke Kitamura
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Antivir Ther 15:1087-97. 2010
    ..Despite the importance of these two predictive factors for combination therapy, their interaction is poorly understood...
  25. ncbi Expression of hypoxia-inducible factor-1alpha is associated with tumor vascularization in human colorectal carcinoma
    Toshio Kuwai
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Int J Cancer 105:176-81. 2003
    ..These findings suggest that HIF-1alpha may play a role in angiogenesis and tumor progression via regulation of VEGF in human colorectal carcinoma...
  26. ncbi Toward the establishment of a prediction system for the personalized treatment of chronic hepatitis C
    Hidenori Ochi
    Laboratory for Digestive Diseases, Center for Genomic Medicine, RIKEN, Hiroshima
    J Infect Dis 205:204-10. 2012
    ..Not all patients require DAA to achieve SVR, whereas others are unlikely to respond even to triple therapy. Therefore, a personalized approach to candidate selection is necessary...
  27. ncbi Cigarette smoking abolishes ischemic preconditioning-induced augmentation of endothelium-dependent vasodilation
    Shuji Nakamura
    Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Mimami ku, Hiroshima 734 8551, Japan
    Hypertension 53:674-81. 2009
    ..However, smoking abolishes ischemic preconditioning stimulus-induced augmentation of endothelium-dependent vasodilation...
  28. ncbi Randomized trial of high-dose interferon-alpha-2b combined with ribavirin in patients with chronic hepatitis C: Correlation between amino acid substitutions in the core/NS5A region and virological response to interferon therapy
    Nami Mori
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Minami Ku, Hiroshima, Japan
    J Med Virol 81:640-9. 2009
    ..Amino acid substitutions in the core and ISDR are predictive of virological response to the therapy in patients with genotype 1b and high viral load...
  29. ncbi Monocyte chemoattractant protein-1 transfection induces angiogenesis and tumorigenesis of gastric carcinoma in nude mice via macrophage recruitment
    Tsuyoshi Kuroda
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences and Health Service Center, Hiroshima University, Japan
    Clin Cancer Res 11:7629-36. 2005
    ..The present study was undertaken to obtain direct evidence that MCP-1 participates in recruitment of macrophages and induction of angiogenesis...
  30. ncbi Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b
    Tomokazu Kawaoka
    Laboratory for Digestive Diseases, Center for Genomic Medicine, RIKEN The Institute of Physical and Chemical Research, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Hepatol 54:408-14. 2011
    ....
  31. ncbi Pretreatment predictor of response, time to progression, and survival to intraarterial 5-fluorouracil/interferon combination therapy in patients with advanced hepatocellular carcinoma
    Kiminori Uka
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Hiroshima 734 8551, Japan
    J Gastroenterol 42:845-53. 2007
    ..We investigated the pretreatment predictive factors of early response, time to progression (TTP), and survival in response to intraarterial 5-FU/IFN combination therapy...
  32. ncbi Effects of acute administration of caffeine on vascular function
    Takashi Umemura
    Department of Cardiovascular Physiology and Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Am J Cardiol 98:1538-41. 2006
    ..In conclusion, these findings suggest that the acute administration of caffeine augments endothelium-dependent vasodilation in healthy young men through an increase in nitric oxide production...
  33. ncbi Infection of human hepatocyte chimeric mouse with genetically engineered hepatitis C virus and its susceptibility to interferon
    Nobuhiko Hiraga
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    FEBS Lett 581:1983-7. 2007
    ..Genetically engineered HCV infection system should be useful for analysis of the mechanisms of resistance of HCV to IFN and other drugs...
  34. ncbi Intra-arterial 5-fluorouracil/interferon combination therapy for advanced hepatocellular carcinoma with or without three-dimensional conformal radiotherapy for portal vein tumor thrombosis
    Yoshio Katamura
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Gastroenterol 44:492-502. 2009
    ..The aim of this study was to elucidate the efficacy of intra-arterial 5-fluorouracil (5-FU) and interferon (IFN) alpha combined with three-dimensional conformal radiotherapy (3D-CRT) for portal vein tumor thrombosis (PVTT)...
  35. ncbi Vascular endothelial growth factor C stimulates progression of human gastric cancer via both autocrine and paracrine mechanisms
    Michiyo Kodama
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Clin Cancer Res 14:7205-14. 2008
    ..VEGFR-3 has also been detected on several malignant cells, but the significance of VEGFR-3 expression on malignant cells remains unclear. In this study, we examined the expression and function of VEGFR-3 in gastric carcinoma cells...
  36. ncbi Oral infection-inflammatory pathway, periodontitis, is a risk factor for endothelial dysfunction in patients with coronary artery disease
    Yukihito Higashi
    Department of Cardiovascular Physiology and Medicine, Hiroshima University, Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Atherosclerosis 206:604-10. 2009
    ..There is an association between inflammation and endothelial dysfunction. The purpose of this study was to evaluate endothelial function in patients with coronary artery disease (CAD) who had periodontitis...
  37. ncbi Single nucleotide polymorphism in the hypoxia-inducible factor-1alpha gene in colorectal carcinoma
    Toshio Kuwai
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Hiroshima 734 8551, Japan
    Oncol Rep 12:1033-7. 2004
    ..0005). These results suggest that the C1772T polymorphism in HIF-1alpha is not involved in progression or metastasis of colorectal carcinoma...
  38. ncbi Intra-arterial 5-fluorouracil/interferon combination therapy for hepatocellular carcinoma with portal vein tumor thrombosis and extrahepatic metastases
    Yoshio Katamura
    Department of Medicine and Molecular Science, Hiroshima University, Hiroshima, Japan
    J Gastroenterol Hepatol 25:1117-22. 2010
    ....
  39. ncbi IL28B polymorphism is associated with fatty change in the liver of chronic hepatitis C patients
    Mayu Ohnishi
    Programs for Biomedical Research, Division of Frontier Medical Science, Department of Gastroenterology and Metabolism, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Gastroenterol 47:834-44. 2012
    ..Recently, an association between γ-GTP level and IL28B genotype was identified. In this study, the relationship between IL28B genotype and liver steatosis was analyzed...
  40. ncbi Stroma-directed imatinib therapy impairs the tumor-promoting effect of bone marrow-derived mesenchymal stem cells in an orthotopic transplantation model of colon cancer
    Kei Shinagawa
    Department of Gastroenterology and Metabolism, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Int J Cancer 132:813-23. 2013
    ..Our data suggest that blockade of PDGF signaling pathways influences the interaction between bone marrow-derived MSCs and tumor cells in the tumor microenvironment and, hence, inhibits the progressive growth of colon cancer...
  41. ncbi Inverse association of IL28B genotype and liver mRNA expression of genes promoting or suppressing antiviral state
    Hiromi Abe
    Laboratory for Digestive Diseases, Center for Genomic Medicine, RIKEN, Hiroshima, Japan Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan Liver Research Project Center, Hiroshima University, Hiroshima, Japan
    J Med Virol 83:1597-607. 2011
    ..These results suggest that rs12979860 genotype may be associated with response to combination therapy through an inverse relationship between antiviral and suppressor ISGs in the liver...
  42. ncbi Serum HBV RNA is a predictor of early emergence of the YMDD mutant in patients treated with lamivudine
    Tsuyoshi Hatakeyama
    Department of Medicine and Molecular Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, and Department of Hepatology, Hiroshima Red Cross Hospital, Hiroshima shi, Japan
    Hepatology 45:1179-86. 2007
    ..456 log copies/ml, P=0.0125) or in whom the YMDD mutant never emerged (n=18, 0.688 log copies/ml, P=0.039). Our results suggest that HBV RNA is a valuable predictor of early occurrence of viral mutation during LAM therapy...
  43. ncbi Relation between histologic gastritis and gastric motility in Japanese patients with functional dyspepsia: evaluation by transabdominal ultrasonography
    Yoshiaki Matsumoto
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Gastroenterol 43:332-7. 2008
    ..Few reports discuss gastric motility in relation to histologic gastritis. We examined the relation between gastric motility and histologic gastritis in Japanese patients with FD...
  44. ncbi Importance of serum concentration of adefovir for Lamivudine-adefovir combination therapy in patients with lamivudine-resistant chronic hepatitis B
    Fukiko Mitsui
    Department of Medical and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Science, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Antimicrob Agents Chemother 54:3205-11. 2010
    ..However, care should be taken to prevent worsening of renal function due to high ADV serum concentrations...
  45. ncbi Anti-stromal therapy with imatinib inhibits growth and metastasis of gastric carcinoma in an orthotopic nude mouse model
    Tomonori Sumida
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Minami Ku, Hiroshima, Japan
    Int J Cancer 128:2050-62. 2011
    ..In conclusion, administration of PDGF-R tyrosine kinase inhibitor in combination with irinotecan appears to impair the progressive growth of gastric carcinoma by blockade of PDGF-R signaling pathways in stromal cells...
  46. ncbi Relationship between endothelial function in the coronary and brachial arteries
    Hiroki Teragawa
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Japan
    Clin Cardiol 28:460-6. 2005
    ..Endothelial dysfunction is the first step in the progression to atherosclerosis, but little is known regarding whether there is a correlation in endothelial function between the coronary and peripheral arteries...
  47. ncbi Prediction of response to peginterferon-alfa-2b plus ribavirin therapy in Japanese patients infected with hepatitis C virus genotype 1b
    Yoshimasa Hashimoto
    Division of Frontier Medical Science, Department of Medical and Molecular Science, Programs for Biomedical Research, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan
    J Med Virol 83:981-8. 2011
    ..In conclusion, host (IL-28B polymorphism) and viral (aa 70) factors independently affect response to combination therapy...
  48. ncbi Impact of pegylated interferon therapy on outcomes of patients with hepatitis C virus-related hepatocellular carcinoma after curative hepatic resection
    Yoshisato Tanimoto
    Department of Gastroenterological Surgery, Hiroshima University Hospital, Hiroshima, Japan
    Ann Surg Oncol 19:418-25. 2012
    ..The aim of this study is to investigate the efficacy of pegylated-IFN (peg-IFN) therapy after curative hepatic resection for HCC in patients infected with hepatitis C virus (HCV)...
  49. ncbi Cytoprotective effect of tauroursodeoxycholate on hepatocyte apoptosis induced by peroxisome proliferator-activated receptor gamma ligand
    Michihiro Nonaka
    Department of Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Gastroenterol Hepatol 23:e198-206. 2008
    ....
  50. ncbi Similar effects of recombinant interferon-alpha-2b and natural interferon-alpha when combined with intra-arterial 5-fluorouracil for the treatment of advanced hepatocellular carcinoma
    Kiminori Uka
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Liver Int 27:1209-16. 2007
    ..In this study, we compared the efficiency and safety of recombinant IFN-alpha-2b with natural IFN-alpha as components of the combination therapy...
  51. ncbi Absence of viral interference and different susceptibility to interferon between hepatitis B virus and hepatitis C virus in human hepatocyte chimeric mice
    Nobuhiko Hiraga
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Hepatol 51:1046-54. 2009
    ..Whether there is interference between these two viruses is still controversial. We investigated the interference between these two viruses and the mode of resistance against IFN...
  52. ncbi Relationship between Helicobacter pylori tyrosine-phosphorylated CagA-related markers and the development of diffuse-type gastric cancers: a case-control study
    Yoshihiro Wada
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Digestion 82:10-7. 2010
    ..Diffuse-type gastric cancer (DGC) has a poor prognosis. We tried to clarify the expression level of CagA-P in DGC patients...
  53. ncbi Successful treatment of an entecavir-resistant hepatitis B virus variant
    Hiromi Yatsuji
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Med Virol 79:1811-7. 2007
    ....
  54. ncbi Genetic and pathologic characteristics of gastrointestinal stromal tumors in extragastric lesions
    Songde Cho
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8551, Japan
    Int J Mol Med 18:1067-71. 2006
    ..These data suggest that extragastric GISTs differ from gastric GISTs with respect to associated mutations and angiogenic activity...
  55. ncbi Atorvastatin decreases serum levels of advanced glycation endproducts (AGEs) in nonalcoholic steatohepatitis (NASH) patients with dyslipidemia: clinical usefulness of AGEs as a biomarker for the attenuation of NASH
    Yuki Kimura
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minamiku, Hiroshima, 734 8551, Japan
    J Gastroenterol 45:750-7. 2010
    ..In this study, to explore the clinical usefulness of AGEs as a biomarker for the attenuation of NASH, we investigated whether the treatment of NASH with dyslipidemia could decrease serum levels of AGEs...
  56. ncbi Advanced glycation end products enhance the proliferation and activation of hepatic stellate cells
    Keiko Iwamoto
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Gastroenterol 43:298-304. 2008
    ..However, direct evidence for the participation of AGEs in hepatic inflammation and fibrosis has not been shown. To explore the pathogenesis of NASH, we examined the biological infl uence of AGEs on hepatic stellate cells (HSCs) in vitro...
  57. ncbi Deletion of the KIT gene is associated with liver metastasis and poor prognosis in patients with gastrointestinal stromal tumor in the stomach
    Songde Cho
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Minami Ku, Hiroshima 734 8551, Japan
    Int J Oncol 28:1361-7. 2006
    ..Our data indicate that KIT mutations, especially deletions in exon 11, are markers of poor prognosis for gastric GISTs...
  58. ncbi Endothelial function in subjects with isolated low HDL cholesterol: role of nitric oxide and circulating progenitor cells
    Yukihito Higashi
    Department of Cardiovascular Physiology and Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Am J Physiol Endocrinol Metab 298:E202-9. 2010
    ....
  59. ncbi IL-28B predicts response to chronic hepatitis C therapy--fine-mapping and replication study in Asian populations
    Hidenori Ochi
    Laboratory for Liver Diseases, the RIKEN Center for Genomic Medicine, Hiroshima, Japan
    J Gen Virol 92:1071-81. 2011
    ..Common variation at the IL-28B locus is predictive of various IFN-based therapies for HCV independent of regimen or HCV genotype...
  60. ncbi Pioglitazone improves endothelium-dependent vasodilation in hypertensive patients with impaired glucose tolerance in part through a decrease in oxidative stress
    Takayuki Hidaka
    Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Atherosclerosis 210:521-4. 2010
    ..The aim of this study was to determine pioglitazone treatment restores endothelial function in hypertensive patients with impaired glucose tolerance (IGT)...
  61. ncbi Establishment of an infectious genotype 1b hepatitis C virus clone in human hepatocyte chimeric mice
    Takashi Kimura
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Gen Virol 89:2108-13. 2008
    ..This mouse model will be useful for the study of HCV virology, particularly the mechanism underlying the variable resistance of HCV genotypes to interferon therapy...
  62. ncbi Vascular function in patients with lower extremity peripheral arterial disease: a comparison of functions in upper and lower extremities
    Hiroaki Sanada
    Department of Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
    Atherosclerosis 178:179-85. 2005
    ....
  63. ncbi IL28 variation affects expression of interferon stimulated genes and peg-interferon and ribavirin therapy
    Hiromi Abe
    Laboratory for Digestive Diseases, Center for Genomic Medicine, RIKEN, Hiroshima, Japan
    J Hepatol 54:1094-101. 2011
    ..Expression of IL28 in peripheral blood cells has been reported to be higher in patients with IL28 SNP genotypes associated with favorable response...
  64. ncbi Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human gastric carcinomas
    Masahiro Ohta
    Department of Medicine and Molecular Science, Hiroshima University, Hiroshima, Japan
    Int J Oncol 22:773-8. 2003
    ..These results suggest that MCP-1 produced by human gastric carcinoma cells plays a role in angiogenesis via macrophage recruitment and activation...
  65. ncbi G-to-A hypermutation in hepatitis B virus (HBV) and clinical course of patients with chronic HBV infection
    Chiemi Noguchi
    Department of Medicine and Molecular Science, Hiroshima University, Hiroshima, Japan
    J Infect Dis 199:1599-607. 2009
    ..The clinical relevance of this protein family is unknown...
  66. ncbi Potential role for vascular endothelial growth factor-D as an autocrine factor for human gastric carcinoma cells
    Miwako Tanaka
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Cancer Sci 101:2121-7. 2010
    ..VEGF-D may participate in the progression of human gastric carcinoma by acting via autocrine and paracrine mechanisms...
  67. ncbi Comparison of forearm endothelial function between premenopausal and postmenopausal women with or without hypercholesterolemia
    Mitsuhiro Sanada
    Department of Obstetrics and Gynecology, Faculty of Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Maturitas 44:307-15. 2003
    ..These findings suggest that reactive hyperemia is impaired in forearm resistance arteries after menopause, especially in postmenopausal women with hypercholesterolemia...
  68. ncbi Expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in early gastric carcinoma: correlation with clinicopathological parameters
    Seiji Onogawa
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8551, Japan
    Cancer Lett 226:85-90. 2005
    ..No association was identified between VEGF-D immunoreactivity and clinicopathological variables. These results suggest that VEGF-C is a dominant regulator of lymphangiogenesis in early-stage human gastric carcinoma...
  69. ncbi Pilot study of systemic combination therapy with S-1, an oral fluoropyrimidine, and cisplatin for hepatocellular carcinoma with extrahepatic metastases
    Yoshio Katamura
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Hepatogastroenterology 57:1272-8. 2010
    ..No grade-4 adverse reaction or toxicity-related death occurred. CONCLUSION; S-1/CDDP is a potentially safe and effective combination therapy for HCC patients with extrahepatic metastases...
  70. ncbi A single nucleotide polymorphism in the MMP-9 promoter affects tumor progression and invasive phenotype of gastric cancer
    Shunji Matsumura
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, 734 8551, Hiroshima, Japan
    J Cancer Res Clin Oncol 131:19-25. 2005
    ..The purpose of this study was to investigate the relation between the -1562 C/T polymorphism and the development and progression of gastric cancer...
  71. ncbi Transarterial infusion chemotherapy using cisplatin-lipiodol suspension with or without embolization for unresectable hepatocellular carcinoma
    Tomokazu Kawaoka
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Science, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8551, Japan
    Cardiovasc Intervent Radiol 32:687-94. 2009
    ..LPD accumulation after the first transarterial infusion chemotherapy is an important prognostic factor. Careful consideration should be given to the possibility of anaphylactic shock upon repeat infusion with CDDP/LPD...
  72. ncbi Percutaneous radiofrequency ablation as first-line treatment for small hepatocellular carcinoma: results and prognostic factors on long-term follow up
    Koji Waki
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Gastroenterol Hepatol 25:597-604. 2010
    ..We evaluated the prognosis and associated factors in patients with small hepatocellular carcinoma (HCC; up to 3 nodules, each up to 3 cm in diameter) treated with percutaneous radiofrequency ablation (RFA) as first-line treatment...
  73. ncbi Epigenetic inactivation of SOCS-1 by CpG island hypermethylation in human gastric carcinoma
    Yasuhiro Oshimo
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Int J Cancer 112:1003-9. 2004
    ..013 and 0.002, respectively). Our results suggest that transcriptional inactivation of the SOCS-1 gene by hypermethylation may be involved in development, progression and metastasis of GC...
  74. ncbi Frequent loss of RUNX3 expression by promoter hypermethylation in gastric carcinoma
    Yasuhiro Oshimo
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Pathobiology 71:137-43. 2004
    ..Our results overall suggest that transcriptional inactivation of RUNX3 by promoter hypermethylation may participate in the stomach carcinogenesis...
  75. ncbi Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients
    Hiromi Abe
    Laboratory for Digestive Diseases, Center for Genomic Medicine, RIKEN, Hiroshima, Japan
    J Hepatol 53:439-43. 2010
    ..An allele associated with a favorable response (rs8099917 T), which is the major allele in the majority of Asian, American, and European populations, has also been found to be associated with spontaneous eradication of the virus...
  76. ncbi Hypersensitivity reactions to transcatheter chemoembolization with cisplatin and Lipiodol suspension for unresectable hepatocellular carcinoma
    Tomokazu Kawaoka
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Science, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Vasc Interv Radiol 21:1219-25. 2010
    ..To assess the predictors of hypersensitivity reaction to chemoembolization procedures with cisplatin and Lipiodol suspension for the treatment of hepatocellular carcinoma (HCC)...
  77. ncbi Roles of rho-associated kinase and oxidative stress in the pathogenesis of aortic stiffness
    Kensuke Noma
    Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Am Coll Cardiol 49:698-705. 2007
    ..The purpose of this study was to determine the relationship between Rho-associated kinase (ROCK) activity and aortic stiffness in humans...
  78. ncbi Presence of poorly differentiated component correlated with submucosal invasion in the early diffuse-type gastric cancer
    Tsuyoshi Kuroda
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Hepatogastroenterology 55:2264-8. 2008
    ..The aim of this study is to distinguish the behaviors of early diffuse-type gastric carcinomas by sub classifying tumors according to their histologic features...
  79. ncbi Adoptive immunotherapy with liver allograft-derived lymphocytes induces anti-HCV activity after liver transplantation in humans and humanized mice
    Masahiro Ohira
    Department of Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Clin Invest 119:3226-35. 2009
    ..Thus, our study presents what we believe to be a novel paradigm for the inhibition of HCV replication in HCV-infected liver transplantation recipients...
  80. ncbi Aging and hypertension are independent risk factors for reduced number of circulating endothelial progenitor cells
    Takashi Umemura
    Department of Cardiovascular Physiology and Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Am J Hypertens 21:1203-9. 2008
    ..The purpose of this study was to evaluate the relationship between the number of EPCs and cardiovascular risk factors...
  81. ncbi Sarpogrelate hydrochloride, a selective 5-hydroxytryptamine(2A) antagonist, augments autologous bone marrow mononuclear cell implantation-induced improvement in endothelium-dependent vasodilation in patients with critical limb ischemia
    Yukihito Higashi
    Departments of Cardiovascular Physiology, Hiroshima University, Hiroshima, Japan
    J Cardiovasc Pharmacol 55:56-61. 2010
    ....
  82. ncbi Measurement of flow-mediated vasodilation of the brachial artery: a comparison of measurements in the seated and supine positions
    Junko Soga
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Minami Ku, Kiroshima, Japan
    Circ J 71:736-40. 2007
    ..However, measurement of FMD while seated would be more comfortable and convenient for patients, so the purpose of this study was to determine the effect of the patient's position on FMD results...
  83. ncbi Role of Helicobacter pylori infection and chronic inflammation in gastric cancer in the cardia
    Yasuo Egi
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Jpn J Clin Oncol 37:365-9. 2007
    ..Recently, we reported that H. pylori is an important factor for the induction of cardiac inflammation. We examined the status of H. pylori-induced gastritis in patients with cardiac cancer...
  84. ncbi Dual effect of APOBEC3G on Hepatitis B virus
    Chiemi Noguchi
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Hiroshima shi 734 8551, Japan
    J Gen Virol 88:432-40. 2007
    ..Our results suggest that APOBEC3G, upregulated by IFNs, has a dual effect on HBV: induction of hypermutation and reduction of virus synthesis. The effect of hypermutation on infectivity should be investigated further...
  85. ncbi Little necessity of acid inhibition against proton pump inhibitor rebound effects and prior helicobacter pylori eradication therapy in gastric ulcer patients: a randomized prospective study
    Yoshihiro Wada
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Hepatogastroenterology 56:624-8. 2009
    ..Rebound acid hypersecretion develops after the use of proton pump inhibitors (PPI). We examined the clinical necessity of acid inhibitors to prevent GERD or RE caused by PPI rebound phenomenon and prior H. pylori eradication therapy...
  86. ncbi Expression of multidrug resistance-associated protein 2 is involved in chemotherapy resistance in human pancreatic cancer
    Bunjiro Noma
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Minami Ku, Hiroshima 734 8551, Japan
    Int J Oncol 33:1187-94. 2008
    ..These observations suggest that MRP2 may correlate to intrinsic and acquired resistance for CDDP in human pancreatic cancer...
  87. ncbi Treatment of functional dyspepsia with serotonin agonists: a meta-analysis of randomized controlled trials
    Toru Hiyama
    Health Service Center, Hiroshima University, Higashihiroshima, Japan
    J Gastroenterol Hepatol 22:1566-70. 2007
    ..The aim of this study was to perform a meta-analysis of randomized controlled trials (RCTs) comparing serotonin agonists with other types of prokinetics in patients with FD...
  88. ncbi Sarpogrelate hydrochloride, a selective 5-HT2A antagonist, improves vascular function in patients with peripheral arterial disease
    Masanori Miyazaki
    Department of Surgery, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    J Cardiovasc Pharmacol 49:221-7. 2007
    ..The changes in FBF and LBF after sublingual NTG were similar during follow-up periods in the 2 groups. These findings suggest that long-term oral administration of sarpogrelate improves vascular function in patients with PAD...
  89. ncbi Evaluation of gastric cancer risk using topography of histological gastritis: a large-scaled cross-sectional study
    Shinobu Imagawa
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi Minami ku, Hiroshima 734 8551, Japan
    Dig Dis Sci 53:1818-23. 2008
    ..3 and 54.7%, which were superior to the serum criteria using pepsinogens. These suggest that topography of histologic gastritis is an important marker to identify the high-risk group...
  90. ncbi Quantitative analysis of lymphangiogenic markers for predicting metastasis of human gastric carcinoma to lymph nodes
    Yasuhiko Kitadai
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Int J Cancer 115:388-92. 2005
    ..These results indicate that quantitative analysis of lymphangiogenic markers in gastric biopsy specimens may be useful in predicting metastasis of gastric cancer to regional lymph nodes...
  91. ncbi Systemic gemcitabine combined with intra-arterial low-dose cisplatin and 5-fluorouracil for advanced hepatocellular carcinoma: seven cases
    Kiminori Uka
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 7348551, Japan
    World J Gastroenterol 14:2602-8. 2008
    ..GEMFP may potentially be effective for non-resectable advanced HCC, but it has severe hematologic toxicity...
  92. ncbi Ablation of the bach1 gene leads to the suppression of atherosclerosis in bach1 and apolipoprotein E double knockout mice
    Yuichiro Watari
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Hypertens Res 31:783-92. 2008
    ..Disruption of the Bach1 gene in Apo E KO mice caused inhibition of atherosclerosis through upregulation of HO-1. Inhibition of Bach1, conversely, may be a novel therapeutic strategy to treat atherosclerotic diseases...
  93. ncbi Low-dose intermittent interferon-alpha therapy for HCV-related liver cirrhosis after curative treatment of hepatocellular carcinoma
    Soocheol Jeong
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3, Kasumi, Hiroshima, Japan
    World J Gastroenterol 13:5188-95. 2007
    ..To assess the efficacy of low-dose intermittent interferon (IFN) therapy in patients with hepatitis C virus (HCV)-related compensated cirrhosis who had received curative treatment for primary hepatocellular carcinoma (HCC)...
  94. ncbi Prospective study of short-term peginterferon-alpha-2a monotherapy in patients who had a virological response at 2 weeks after initiation of interferon therapy
    Soocheol Jeong
    Department of Medicine and Molecular Science, Hiroshima University, Hiroshima, Japan
    J Gastroenterol Hepatol 23:541-5. 2008
    ..To assess whether short-term IFN therapy effectively eliminates HCV, we performed a prospective pilot study of pegylated (peg)IFN-alpha-2a therapy for 8 or 24 weeks...
  95. ncbi Clinicopathological features of elderly patients with hepatitis C virus-related hepatocellular carcinoma
    Daiki Miki
    Department of Medicine and Molecular Science, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Gastroenterol 43:550-7. 2008
    ..However, there is little information on the impact of aging on hepatocarcinogenesis. The aim of this study was to elucidate the clinicopathological features of elderly patients with HCV-related HCC...
  96. ncbi Beneficial effects of living-donor liver transplantation on esophageal varices
    Tomokazu Kawaoka
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Gastroenterol 43:982-9. 2008
    ....
  97. ncbi Pathogenetic role of the tyrosine-phosphorylated CagA EPIYA sequence of Helicobacter pylori in histological gastritis in Japanese patients
    Shunsuke Takata
    Department of Medicine and Molecular Science, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan
    J Gastroenterol 44:405-11. 2009
    ..pylori) CagA protein plays an important role in the clinical outcome of gastritis treatment. Tyrosine phosphorylated Glu-Pro-Ile-Tyr-Ala motif in CagA (CagA-P) plays a critical role in the morphological transformation of cells...
  98. ncbi Combination therapy of oral fluoropyrimidine anticancer drug S-1 and interferon alpha for HCC patients with extrahepatic metastases
    Kiminori Uka
    Programs for Biomedical Research, Division of Frontier Medical Science, Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Oncology 75:8-16. 2008
    ..We assessed the efficiency and safety of the oral fluoropyrimidine anticancer drug S-1 combined with interferon alpha (IFN-alpha) for HCC patients with extrahepatic metastases...
  99. ncbi A polymorphism in MAPKAPK3 affects response to interferon therapy for chronic hepatitis C
    Hironobu Tsukada
    Laboratory for Digestive Diseases, Center for Genomic Medicine, RIKEN The Institute of Physical and Chemical Research, Kasumi, Minami Ku, Hiroshima, Japan
    Gastroenterology 136:1796-805.e6. 2009
    ..This study aimed to identify host single nucleotide polymorphisms (SNPs) that are associated with the efficacy of interferon (IFN) therapy in patients with chronic hepatitis C...
  100. ncbi Hormone replacement effects on endothelial function measured in the forearm resistance artery in normocholesterolemic and hypercholesterolemic postmenopausal women
    Mitsuhiro Sanada
    Department of Obstetrics and Gynecology, Faculty of Medicine, Hiroshima University, Hiroshima 734 8551, Japan
    J Clin Endocrinol Metab 87:4634-41. 2002
    ..5%; P < 0.05). Changes in the FBF with NTG were not altered by HRT in either group. Long-term HRT augments endothelial function in forearm resistance artery. This beneficial effect is greater in patients with hypercholesterolemia...
  101. ncbi Response of the left anterior descending coronary artery to acetylcholine in patients with chest pain and angiographically normal coronary arteries
    Keiji Matsuda
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Am J Cardiol 92:1394-8. 2003
    ....